SIMILAR PATTERNS OF AMINO ACIDS FOR 3OSH_A_OINA5811_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1a2a PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.36A 3oshA-1a2aA:
19.1		 3oshA-1a2aA:
40.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ae7 PHOSPHOLIPASE A2

(Notechis
scutatus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.75A 3oshA-1ae7A:
19.0		 3oshA-1ae7A:
53.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LEU B   2
PHE B   5
ILE B   9
GLY B  30
HIS B  48
 None
ACT  B 134 (-4.6A)
None
ACT  B 134 (-3.7A)
ACT  B 134 (-3.6A)
 0.41A 3oshA-1aokB:
19.7		 3oshA-1aokB:
43.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
 None
None
None
None
CA  A 124 (-4.2A)
None
 0.67A 3oshA-1bpqA:
20.9		 3oshA-1bpqA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		6 PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
TYR A  69
 None
None
None
CA  A 124 (-4.2A)
None
None
 0.42A 3oshA-1bpqA:
20.9		 3oshA-1bpqA:
54.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
PHE A   5
ILE A   9
TRP A  19
GLY A  30
HIS A  48
 None
None
None
None
NA  A 150 (-4.5A)
None
 0.73A 3oshA-1dpyA:
20.2		 3oshA-1dpyA:
62.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.48A 3oshA-1g0zA:
19.7		 3oshA-1g0zA:
60.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
TRP A  19
GLY A  30
 None
 0.80A 3oshA-1g0zA:
19.7		 3oshA-1g0zA:
60.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gp7 PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
PHE A   5
ILE A   9
TRP A  19
GLY A  30
HIS A  48
 None
None
None
None
CA  A1125 (-4.5A)
None
 0.74A 3oshA-1gp7A:
21.6		 3oshA-1gp7A:
52.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ijl PHOSPHOLIPASE A2

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  29
HIS A  47
 None
None
None
CA  A 203 (-4.5A)
None
 0.66A 3oshA-1ijlA:
17.7		 3oshA-1ijlA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8r PHOSPHOLIPASE A2

(Gloydius halys) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
BU1  A1002 ( 4.8A)
None
BU1  A1002 (-4.3A)
None
 0.67A 3oshA-1m8rA:
17.2		 3oshA-1m8rA:
38.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1m8t PHOSPHOLIPASE A2

(Ophiophagus
hannah) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 HEZ  A1002 (-4.0A)
None
None
CA  A1001 (-4.3A)
None
 0.36A 3oshA-1m8tA:
22.8		 3oshA-1m8tA:
67.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh2 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		6 PHE A   5
ILE A   9
TRP A  19
PHE A  22
GLY A  30
HIS A  48
 None
None
None
None
None
ACY  A 302 (-3.4A)
 0.67A 3oshA-1mh2A:
23.0		 3oshA-1mh2A:
76.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mh8 PHOSPHOLIPASE A2

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		6 PHE A   5
ILE A   9
TRP A  19
PHE A  22
GLY A  30
HIS A  48
 None
 0.25A 3oshA-1mh8A:
24.7		 3oshA-1mh8A:
83.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ozy PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
PHE A  22
HIS A  48
 None
 0.65A 3oshA-1ozyA:
17.5		 3oshA-1ozyA:
54.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
LYS A  31
HIS A  48
TYR A  69
 None
 1.24A 3oshA-1p7oA:
20.8		 3oshA-1p7oA:
59.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1p7o PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		7 LEU A   2
PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
TYR A  69
 None
 0.52A 3oshA-1p7oA:
20.8		 3oshA-1p7oA:
59.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pp2 CALCIUM-FREE
PHOSPHOLIPASE A2

(Crotalus atrox) 		no annotation 5 LEU R   2
PHE R   5
ILE R   9
GLY R  30
HIS R  48
 None
 0.90A 3oshA-1pp2R:
17.4		 3oshA-1pp2R:
37.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		5 PHE A   5
ILE A   9
PHE A  21
GLY A  29
HIS A  47
 None
None
None
CA  A 120 (-4.4A)
None
 0.61A 3oshA-1pshA:
23.1		 3oshA-1pshA:
92.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1psh PHOSPHOLIPASE A2

(Naja naja) 		PF00068
(Phospholip_A2_1) 		5 PHE A   5
ILE A   9
PHE A  21
HIS A  47
TYR A  63
 None
 0.30A 3oshA-1pshA:
23.1		 3oshA-1pshA:
92.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		7 LEU A   2
PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
TYR A  69
 None
 0.49A 3oshA-1pwoA:
20.2		 3oshA-1pwoA:
59.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pwo PHOSPHOLIPASE A2

(Micropechis
ikaheca) 		PF00068
(Phospholip_A2_1) 		6 PHE A   5
ILE A   9
PHE A  22
GLY A  30
LYS A  31
HIS A  48
 None
 0.80A 3oshA-1pwoA:
20.2		 3oshA-1pwoA:
59.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vap PHOSPHOLIPASE A2

(Agkistrodon
piscivorus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  29
HIS A  47
 None
 0.37A 3oshA-1vapA:
18.2		 3oshA-1vapA:
40.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.50A 3oshA-1vipA:
18.8		 3oshA-1vipA:
43.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 104
PHE A 136
ILE A  60
PHE A  47
TYR A 133
 None
None
None
ADP  A 550 (-4.9A)
None
 1.45A 3oshA-1xtjA:
undetectable		 3oshA-1xtjA:
14.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 5

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		6 PHE A   5
ILE A   9
TRP A  19
PHE A  22
GLY A  30
HIS A  48
 NAG  A 301 (-4.2A)
None
NAG  A 301 (-4.7A)
None
NAG  A 301 (-4.0A)
NAG  A 301 (-3.9A)
 0.36A 3oshA-1y75A:
23.1		 3oshA-1y75A:
85.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1y75 PHOSPHOLIPASE A2
ISOFORM 6

(Naja
sagittifera) 		PF00068
(Phospholip_A2_1) 		6 PHE B   5
ILE B   9
TRP B  19
PHE B  22
GLY B  30
HIS B  48
 None
 0.82A 3oshA-1y75B:
22.4		 3oshA-1y75B:
77.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h4c PHOSPHOLIPASE A2-II

(Daboia
siamensis) 		PF00068
(Phospholip_A2_1) 		5 LEU B   2
PHE B   5
ILE B   9
GLY B  30
HIS B  48
 None
 0.50A 3oshA-2h4cB:
17.6		 3oshA-2h4cB:
42.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   4
PHE A   7
ILE A  11
TRP A  19
GLY A  30
HIS A  48
 None
 0.70A 3oshA-2osnA:
19.7		 3oshA-2osnA:
62.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pbe AMINOGLYCOSIDE
6-ADENYLYLTRANSFERAS
E

(Bacillus
subtilis) 		PF04439
(Adenyl_transf) 		5 LEU A 125
PHE A 206
ILE A 144
TRP A 143
GLY A 203
 None
 1.38A 3oshA-2pbeA:
undetectable		 3oshA-2pbeA:
15.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 None
 0.62A 3oshA-2qogA:
17.3		 3oshA-2qogA:
36.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq0 GERANYL DIPHOSPHATE
SYNTHASE

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		5 LEU A 246
PHE A 239
ILE A 254
GLY A 299
LYS A 298
 None
 1.48A 3oshA-3aq0A:
undetectable		 3oshA-3aq0A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e38 TWO-DOMAIN PROTEIN
CONTAINING PREDICTED
PHP-LIKE
METAL-DEPENDENT
PHOSPHOESTERASE

(Bacteroides
vulgatus) 		PF16392
(DUF5001) 		5 ILE A 126
PHE A 127
GLY A 150
LYS A 148
HIS A 184
 None
 1.33A 3oshA-3e38A:
undetectable		 3oshA-3e38A:
15.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3g8g PHOSPHOLIPASE A2,
AMMODYTOXIN A

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  29
HIS A  47
 None
 0.82A 3oshA-3g8gA:
18.3		 3oshA-3g8gA:
38.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p2p PHOSPHOLIPASE A2

(Sus scrofa) 		PF00068
(Phospholip_A2_1) 		7 LEU A   2
PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
TYR A  69
 None
None
None
None
CA  A 125 (-4.3A)
None
None
 0.65A 3oshA-3p2pA:
21.7		 3oshA-3p2pA:
58.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3v9m PHOSPHOLIPASE A2
ISOZYME PA-11

(Pseudechis
australis) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
PHE A   5
ILE A   9
GLY A  30
HIS A  48
 EDO  A 201 ( 4.7A)
EDO  A 201 (-4.6A)
None
EDO  A 201 (-3.5A)
EDO  A 201 ( 4.0A)
 0.34A 3oshA-3v9mA:
22.0		 3oshA-3v9mA:
58.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3vbz PHOSPHOLIPASE A2
HOMOLOG, TAIPOXIN
BETA CHAIN

(Oxyuranus
scutellatus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
PHE A   5
ILE A   9
PHE A  22
GLY A  30
HIS A  48
 None
 0.73A 3oshA-3vbzA:
21.0		 3oshA-3vbzA:
50.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rfp ACIDIC PHOSPHOLIPASE
A2 5

(Trimeresurus
stejnegeri) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
PHE A   5
ILE A   9
GLY A  29
LYS A  30
HIS A  47
 None
 0.75A 3oshA-4rfpA:
18.0		 3oshA-4rfpA:
41.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whx BRANCHED-CHAIN-AMINO
-ACID TRANSAMINASE

(Burkholderia
pseudomallei) 		PF01063
(Aminotran_4) 		5 LEU A 132
ILE A 265
PHE A 201
GLY A 198
TYR A 131
 None
None
None
ALA  A 401 (-4.0A)
EDO  A 402 (-3.7A)
 1.26A 3oshA-4whxA:
undetectable		 3oshA-4whxA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y85 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 8

(Homo sapiens) 		PF00069
(Pkinase) 		5 PHE A 271
ILE A 181
GLY A 240
LYS A 239
HIS A 251
 None
 1.45A 3oshA-4y85A:
undetectable		 3oshA-4y85A:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmi TELOMERE LENGTH
REGULATOR TAZ1

(Schizosaccharomyces
pombe) 		PF08558
(TRF) 		5 LEU A 237
PHE A 172
ILE A 166
GLY A 177
LYS A 178
 None
 1.43A 3oshA-4zmiA:
undetectable		 3oshA-4zmiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bp7 SAM-DEPENDENT
METHYLTRANSFERASE

(Geobacter
sulfurreducens) 		PF13847
(Methyltransf_31) 		5 LEU A  71
PHE A  72
ILE A   4
PHE A   8
HIS A  18
 None
SAH  A 301 (-4.7A)
SAH  A 301 (-3.8A)
None
SAH  A 301 (-4.4A)
 1.31A 3oshA-5bp7A:
undetectable		 3oshA-5bp7A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hr4 MMEI

(Methylophilus
methylotrophus) 		no annotation 5 LEU C 298
PHE C 295
ILE C 290
TRP C 287
PHE C 198
 None
 1.17A 3oshA-5hr4C:
undetectable		 3oshA-5hr4C:
8.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1u NAD(P)H:FLAVIN
OXIDOREDUCTASE SYE4

(Shewanella
oneidensis) 		PF00724
(Oxidored_FMN) 		5 LEU A 282
PHE A 253
ILE A 235
HIS A 194
TYR A 281
 None
 1.40A 3oshA-5k1uA:
undetectable		 3oshA-5k1uA:
16.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sup ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 121
PHE A 153
ILE A  77
PHE A  64
TYR A 150
 None
None
None
ADP  A1000 ( 4.6A)
None
 1.47A 3oshA-5supA:
undetectable		 3oshA-5supA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suq ATP-DEPENDENT RNA
HELICASE SUB2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 LEU A 121
PHE A 153
ILE A  77
PHE A  64
TYR A 150
 None
 1.48A 3oshA-5suqA:
undetectable		 3oshA-5suqA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3b GLYCOSIDE HYDROLASE

(Bacteroides
plebeius) 		no annotation 5 LEU A 242
PHE A 284
ILE A 287
GLY A 195
LYS A 193
 None
 1.17A 3oshA-5t3bA:
undetectable		 3oshA-5t3bA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t6o POLY-BETA-HYDROXYBUT
ERATE POLYMERASE

(Cupriavidus
necator) 		PF07167
(PhaC_N) 		5 LEU A 346
PHE A 318
ILE A 252
GLY A 511
TYR A 475
 None
 1.42A 3oshA-5t6oA:
undetectable		 3oshA-5t6oA:
15.30