SIMILAR PATTERNS OF AMINO ACIDS FOR 3OOI_A_SAMA237

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		5 ARG A  65
GLY A  47
ASN A  60
HIS A  64
LEU A  58
 None
 1.32A 3ooiA-1f2jA:
undetectable		 3ooiA-1f2jA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mvh CRYPTIC LOCI
REGULATOR 4

(Schizosaccharomyces
pombe) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 339
TRP A 340
TYR A 381
ASN A 409
HIS A 410
 None
 0.52A 3ooiA-1mvhA:
17.5		 3ooiA-1mvhA:
27.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		10 ARG A 159
GLY A 160
TRP A 161
TYR A 204
ASN A 241
HIS A 242
TYR A 283
CYH A 306
CYH A 308
LEU A 317
 None
SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.0A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 ( 2.3A)
ZN  A   4 (-2.2A)
SAH  A 319 (-3.9A)
 0.63A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 160
TRP A 161
ASN A 241
HIS A 242
CYH A 306
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-3.6A)
SAH  A 319 (-4.3A)
ZN  A   4 ( 2.3A)
 1.48A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1peg HISTONE H3
METHYLTRANSFERASE
DIM-5

(Neurospora
crassa) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 160
TRP A 161
HIS A 242
TYR A 283
CYH A 308
 SAH  A 319 ( 4.6A)
SAH  A 319 (-4.8A)
SAH  A 319 (-4.3A)
SAH  A 319 (-4.7A)
ZN  A   4 (-2.2A)
 1.30A 3ooiA-1pegA:
19.6		 3ooiA-1pegA:
30.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		5 GLY A 276
ASN A 135
TYR A 290
CYH A 307
LEU A 301
 None
 1.32A 3ooiA-1spiA:
undetectable		 3ooiA-1spiA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb3 PEPTIDOGLYCAN-RECOGN
ITION PROTEIN-LE

(Drosophila
melanogaster) 		PF01510
(Amidase_2) 		5 GLY A 265
ASN A 267
ASN A 318
CYH A 315
LEU A 205
 None
MLD  A1345 (-3.2A)
MLD  A1345 (-3.2A)
None
MLD  A1345 ( 4.6A)
 1.35A 3ooiA-2cb3A:
undetectable		 3ooiA-2cb3A:
20.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 ARG A 150
GLY A 149
HIS A 220
CYH A 289
LEU A 298
 None
None
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.03A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		10 ARG A 150
GLY A 151
TRP A 152
TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
CYH A 289
LEU A 298
 None
SAM  A 304 (-3.5A)
None
SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 0.69A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A 151
TRP A 152
ASN A 219
HIS A 220
TYR A 261
CYH A 287
 SAM  A 304 (-3.5A)
None
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
 1.22A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r3a HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV39H2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 TYR A 193
ASN A 219
HIS A 220
TYR A 261
CYH A 287
LYS A 288
CYH A 289
LEU A 298
 SAM  A 304 (-4.2A)
SAM  A 304 (-3.3A)
SAM  A 304 (-4.9A)
SAM  A 304 (-4.9A)
ZN  A 300 ( 2.3A)
None
ZN  A 300 ( 2.3A)
SAM  A 304 (-4.7A)
 1.01A 3ooiA-2r3aA:
19.6		 3ooiA-2r3aA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		7 GLY A3840
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4971 ( 3.7A)
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
ZN  A4970 (-2.3A)
SAH  A4971 ( 4.9A)
 0.51A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		6 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3959
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-3.1A)
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 0.63A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3840
TYR A3883
HIS A3907
TYR A3944
CYH A3957
 SAH  A4971 ( 3.7A)
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 ( 2.3A)
 1.44A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		5 GLY A3842
TYR A3883
HIS A3907
TYR A3944
CYH A3959
 None
None
SAH  A4971 (-4.7A)
SAH  A4971 (-4.9A)
ZN  A4970 (-2.3A)
 1.32A 3ooiA-2w5zA:
14.2		 3ooiA-2w5zA:
30.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 136
TRP A 137
ASN A 209
HIS A 210
CYH A 273
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-3.4A)
None
ZN  A 304 ( 2.3A)
 1.12A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		9 GLY A 136
TRP A 137
TYR A 178
ASN A 209
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 SAH  A 305 (-3.8A)
None
SAH  A 305 (-4.0A)
SAH  A 305 (-3.4A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 0.64A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		7 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 273
CYH A 275
LEU A 284
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
ZN  A 304 ( 2.3A)
SAH  A 305 (-4.5A)
 1.18A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bo5 HISTONE-LYSINE
N-METHYLTRANSFERASE
SETMAR

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A 138
TYR A 178
HIS A 210
TYR A 248
CYH A 275
 None
SAH  A 305 (-4.0A)
None
SAH  A 305 (-4.9A)
ZN  A 304 ( 2.3A)
 1.06A 3ooiA-3bo5A:
20.9		 3ooiA-3bo5A:
30.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e9k KYNURENINASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		5 ASN A  74
TYR A 277
ASN A 442
TYR A 441
LEU A  78
 None
 1.33A 3ooiA-3e9kA:
undetectable		 3ooiA-3e9kA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ky9 PROTO-ONCOGENE VAV

(Homo sapiens) 		PF00130
(C1_1)
PF00169
(PH)
PF00621
(RhoGEF)
PF11971
(CAMSAP_CH) 		5 TYR A 541
HIS A 554
CYH A 529
LYS A 530
LEU A 536
 None
ZN  A 901 (-3.3A)
ZN  A 901 (-2.5A)
None
None
 1.31A 3ooiA-3ky9A:
undetectable		 3ooiA-3ky9A:
18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  16
HIS A 206
TYR A 252
CYH A 274
CYH A 276
 None
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
ZN  A 497 (-2.5A)
 1.03A 3ooiA-3n71A:
5.8		 3ooiA-3n71A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n71 HISTONE LYSINE
METHYLTRANSFERASE
SMYD1

(Mus musculus) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  18
ASN A 205
HIS A 206
TYR A 252
CYH A 274
 SFG  A 491 ( 4.2A)
SFG  A 491 (-3.3A)
None
SFG  A 491 (-4.8A)
ZN  A 497 (-2.2A)
 0.40A 3ooiA-3n71A:
5.8		 3ooiA-3n71A:
18.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		12 ARG A 101
GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
HIS A 170
TYR A 207
CYH A 219
LYS A 220
CYH A 221
LEU A 230
 SO4  A 235 ( 4.0A)
SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
SAM  A 237 (-4.7A)
None
ZN  A 232 ( 2.3A)
None
ZN  A 232 (-2.3A)
SAM  A 237 (-4.8A)
 0.00A 3ooiA-3ooiA:
40.1		 3ooiA-3ooiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ooi HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-36 AND H4
LYSINE-20 SPECIFIC

(Homo sapiens) 		PF00856
(SET) 		7 GLY A 102
TRP A 103
ASN A 144
TYR A 146
ASN A 169
CYH A 171
LEU A 230
 SAM  A 237 ( 3.7A)
None
SAM  A 237 (-3.9A)
SAM  A 237 (-4.1A)
SAM  A 237 (-3.3A)
None
SAM  A 237 (-4.8A)
 1.30A 3ooiA-3ooiA:
40.1		 3ooiA-3ooiA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		9 GLY A2151
TRP A2152
TYR A2194
ASN A2217
HIS A2218
TYR A2255
CYH A2268
LYS A2269
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
SAM  A   7 (-3.9A)
None
None
ZN  A   1 ( 2.5A)
None
ZN  A   1 (-2.7A)
 0.46A 3ooiA-3opeA:
26.0		 3ooiA-3opeA:
41.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ope PROBABLE
HISTONE-LYSINE
N-METHYLTRANSFERASE
ASH1L

(Homo sapiens) 		PF00856
(SET) 		6 GLY A2151
TRP A2152
TYR A2194
HIS A2218
TYR A2255
CYH A2270
 SAM  A   7 (-3.4A)
None
SAM  A   7 (-3.4A)
None
None
ZN  A   1 (-2.7A)
 1.39A 3ooiA-3opeA:
26.0		 3ooiA-3opeA:
41.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		5 GLY A  74
TYR A 223
ASN A 251
HIS A 252
TYR A 285
 SAM  A 484 (-3.4A)
SAM  A 484 (-3.6A)
SAM  A 484 (-3.1A)
None
SAM  A 484 (-4.8A)
 0.93A 3ooiA-3rc0A:
6.0		 3ooiA-3rc0A:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4au7 HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H2

(Mus musculus) 		PF00856
(SET) 		5 ASN A 182
HIS A 183
TYR A 217
CYH A 229
CYH A 231
 SAH  A1247 (-3.1A)
SAH  A1247 (-4.6A)
None
ZN  A1248 ( 2.3A)
ZN  A1248 ( 2.2A)
 0.30A 3ooiA-4au7A:
7.7		 3ooiA-4au7A:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4duu PLASMINOGEN

(Homo sapiens) 		PF00024
(PAN_1)
PF00051
(Kringle)
PF00089
(Trypsin) 		5 GLY A 415
TRP A 417
HIS A 360
CYH A 435
CYH A 358
 None
 1.26A 3ooiA-4duuA:
undetectable		 3ooiA-4duuA:
15.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1561
TRP A1562
ASN A1628
HIS A1629
CYH A1678
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
 1.04A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		8 GLY A1561
TRP A1562
TYR A1605
ASN A1628
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 0UM  A1804 (-3.5A)
None
0UM  A1804 (-4.2A)
0UM  A1804 (-3.3A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 0.46A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fmu HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD2

(Homo sapiens) 		PF00856
(SET) 		6 GLY A1563
TYR A1605
HIS A1629
CYH A1678
CYH A1680
LEU A1689
 None
0UM  A1804 (-4.2A)
None
ZN  A1803 ( 2.2A)
ZN  A1803 (-2.2A)
0UM  A1804 (-4.8A)
 1.35A 3ooiA-4fmuA:
25.2		 3ooiA-4fmuA:
39.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mi5 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 628
TRP A 629
ASN A 693
HIS A 694
TYR A 731
 None
 0.77A 3ooiA-4mi5A:
15.1		 3ooiA-4mi5A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		8 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
CYH A 612
CYH A 614
LEU A 623
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
None
 0.72A 3ooiA-4qeoA:
18.1		 3ooiA-4qeoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qeo HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-9 SPECIFIC
SUVH4

(Arabidopsis
thaliana) 		PF00856
(SET)
PF02182
(SAD_SRA)
PF05033
(Pre-SET) 		8 GLY A 457
TRP A 458
TYR A 493
ASN A 551
HIS A 552
TYR A 593
CYH A 612
CYH A 614
 SAH  A 801 (-3.6A)
SAH  A 801 (-4.9A)
SAH  A 801 (-4.0A)
SAH  A 801 (-3.2A)
None
None
ZN  A 805 ( 2.4A)
ZN  A 805 ( 2.4A)
 0.54A 3ooiA-4qeoA:
18.1		 3ooiA-4qeoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT

(Anolis
carolinensis) 		no annotation 5 GLY A 520
TRP A 521
ASN A 585
HIS A 586
TYR A 623
 CJD  A 708 (-3.6A)
None
CJD  A 708 (-3.5A)
None
None
 0.61A 3ooiA-4w2rA:
21.7		 3ooiA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		7 GLY A5408
TYR A5451
ASN A5474
HIS A5475
TYR A5512
CYH A5525
CYH A5527
 SAH  A5602 (-3.6A)
SAH  A5602 (-4.5A)
SAH  A5602 (-3.1A)
None
None
ZN  A5601 ( 2.2A)
ZN  A5601 ( 2.2A)
 0.28A 3ooiA-4z4pA:
16.4		 3ooiA-4z4pA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4p HISTONE-LYSINE
N-METHYLTRANSFERASE
2D

(Homo sapiens) 		PF00856
(SET) 		5 GLY A5410
TYR A5451
HIS A5475
TYR A5512
CYH A5527
 None
SAH  A5602 (-4.5A)
None
None
ZN  A5601 ( 2.2A)
 1.47A 3ooiA-4z4pA:
16.4		 3ooiA-4z4pA:
23.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cpr HISTONE-LYSINE
N-METHYLTRANSFERASE
SUV420H1

(Homo sapiens) 		PF00856
(SET) 		5 ASN B 272
HIS B 273
TYR B 307
CYH B 319
CYH B 321
 SAM  B 402 (-3.1A)
SAM  B 402 (-4.5A)
539  B 403 ( 3.9A)
ZN  B 401 ( 2.3A)
ZN  B 401 ( 2.2A)
 0.39A 3ooiA-5cprB:
7.7		 3ooiA-5cprB:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		7 GLY A4782
TYR A4825
ASN A4848
HIS A4849
TYR A4886
CYH A4899
CYH A4901
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-2.7A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
ZN  A5001 (-2.3A)
 0.50A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 GLY A4782
TYR A4825
HIS A4849
TYR A4886
CYH A4899
 SAH  A5002 (-3.5A)
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 ( 2.0A)
 1.44A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f59 HISTONE-LYSINE
N-METHYLTRANSFERASE
2C

(Homo sapiens) 		PF00856
(SET) 		5 GLY A4784
TYR A4825
HIS A4849
TYR A4886
CYH A4901
 None
SAH  A5002 (-4.5A)
SAH  A5002 (-4.6A)
None
ZN  A5001 (-2.3A)
 1.41A 3ooiA-5f59A:
16.5		 3ooiA-5f59A:
24.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f6l HISTONE-LYSINE
N-METHYLTRANSFERASE
2A

(Homo sapiens) 		PF00856
(SET) 		8 GLY A3840
TYR A3883
ASN A3906
HIS A3907
TYR A3944
CYH A3957
CYH A3959
LEU A3968
 SAH  A4001 (-3.4A)
None
SAH  A4001 (-3.0A)
SAH  A4001 (-4.9A)
SAH  A4001 (-4.9A)
ZN  A4002 ( 2.3A)
ZN  A4002 (-2.3A)
None
 0.65A 3ooiA-5f6lA:
16.0		 3ooiA-5f6lA:
26.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjm N-LYSINE
METHYLTRANSFERASE
SMYD2

(Homo sapiens) 		PF00856
(SET)
PF01753
(zf-MYND) 		5 GLY A  18
ASN A 206
HIS A 207
TYR A 240
CYH A 262
 SAM  A 501 ( 4.1A)
SAM  A 501 (-3.2A)
None
6TM  A 502 ( 3.6A)
ZN  A 505 (-2.3A)
 0.44A 3ooiA-5kjmA:
6.0		 3ooiA-5kjmA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		5 GLY A 623
TRP A 624
ASN A 688
HIS A 689
TYR A 726
 74D  A 809 ( 3.9A)
None
74D  A 809 (-3.0A)
None
None
 0.82A 3ooiA-5ls6A:
19.2		 3ooiA-5ls6A:
16.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		10 ARG A1073
GLY A1074
TRP A1075
TYR A1118
ASN A1141
HIS A1142
TYR A1179
CYH A1191
CYH A1193
LEU A1202
 None
SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-2.9A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 ( 2.3A)
ZN  A1301 (-2.3A)
SAM  A1304 ( 4.7A)
 0.36A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		6 GLY A1074
TRP A1075
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 3.2A)
None
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.46A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5lsu HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD2

(Homo sapiens) 		PF00856
(SET) 		5 GLY A1076
TYR A1118
HIS A1142
TYR A1179
CYH A1193
 SAM  A1304 ( 4.6A)
SAM  A1304 (-3.8A)
SAM  A1304 (-4.6A)
SAM  A1304 (-4.1A)
ZN  A1301 (-2.3A)
 1.08A 3ooiA-5lsuA:
33.7		 3ooiA-5lsuA:
72.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5teg N-LYSINE
METHYLTRANSFERASE
KMT5A

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 227
TYR A 271
ASN A 298
HIS A 299
TYR A 336
 SAM  A 401 ( 4.0A)
SAM  A 401 (-4.1A)
SAM  A 401 (-3.2A)
None
SAM  A 401 (-4.8A)
 0.35A 3ooiA-5tegA:
15.2		 3ooiA-5tegA:
23.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TRP A1050
ASN A1112
HIS A1113
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
ZN  A1504 (-2.2A)
 1.23A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1049
TRP A1050
HIS A1113
TYR A1154
CYH A1168
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.37A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 GLY A1049
TRP A1050
TYR A1085
ASN A1112
HIS A1113
TYR A1154
CYH A1168
CYH A1170
 SAM  A1505 ( 3.9A)
None
SAM  A1505 (-4.0A)
SAM  A1505 (-3.4A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
ZN  A1504 (-2.2A)
 0.35A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tuy HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT2

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1051
TYR A1085
HIS A1113
TYR A1154
CYH A1170
 None
SAM  A1505 (-4.0A)
SAM  A1505 (-4.7A)
SAM  A1505 (-4.9A)
ZN  A1504 (-2.2A)
 1.43A 3ooiA-5tuyA:
19.1		 3ooiA-5tuyA:
30.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		8 GLY A1137
TRP A1138
TYR A1173
ASN A1200
HIS A1201
TYR A1242
CYH A1256
CYH A1258
 SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-3.4A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 ( 2.4A)
ZN  A3005 (-2.3A)
 0.43A 3ooiA-5vsdA:
19.6		 3ooiA-5vsdA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		6 GLY A1137
TRP A1138
TYR A1173
HIS A1201
TYR A1242
CYH A1258
 SAM  A3001 (-3.6A)
None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
 1.42A 3ooiA-5vsdA:
19.6		 3ooiA-5vsdA:
30.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vsd HISTONE-LYSINE
N-METHYLTRANSFERASE
EHMT1

(Homo sapiens) 		PF00856
(SET)
PF05033
(Pre-SET) 		5 GLY A1139
TYR A1173
HIS A1201
TYR A1242
CYH A1258
 None
SAM  A3001 (-4.0A)
SAM  A3001 (-4.6A)
SAM  A3001 (-4.8A)
ZN  A3005 (-2.3A)
 1.42A 3ooiA-5vsdA:
19.6		 3ooiA-5vsdA:
30.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wg6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,POLYCOMB
PROTEIN SUZ12
(E.C.2.1.1.43)
CHIMERA

(Homo sapiens) 		no annotation 5 GLY A 623
TRP A 624
ASN A 688
HIS A 689
TYR A 726
 A9G  A9009 ( 4.2A)
None
A9G  A9009 (-3.1A)
None
None
 0.71A 3ooiA-5wg6A:
19.7		 3ooiA-5wg6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 ARG A  14
ASN A 205
HIS A 206
TYR A 239
CYH A 261
 SAM  A 502 (-4.8A)
SAM  A 502 (-3.1A)
None
8HR  A 501 ( 4.0A)
ZN  A 503 (-2.2A)
 0.98A 3ooiA-5xxgA:
5.8		 3ooiA-5xxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxg -

(-) 		no annotation 5 GLY A  15
ASN A 205
HIS A 206
TYR A 239
CYH A 261
 SAM  A 502 ( 3.9A)
SAM  A 502 (-3.1A)
None
8HR  A 501 ( 4.0A)
ZN  A 503 (-2.2A)
 0.66A 3ooiA-5xxgA:
5.8		 3ooiA-5xxgA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 10 ARG A1155
GLY A1156
TRP A1157
ASN A1198
TYR A1200
ASN A1223
HIS A1224
CYH A1273
CYH A1275
LEU A1284
 None
SAM  A1301 (-3.6A)
None
SAM  A1301 (-3.8A)
SAM  A1301 (-3.9A)
SAM  A1301 (-3.2A)
None
ZN  A1304 ( 2.3A)
ZN  A1304 (-2.3A)
SAM  A1301 (-4.6A)
 0.67A 3ooiA-6cenA:
32.8		 3ooiA-6cenA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 10 ARG A1155
GLY A1156
TRP A1157
ASN A1198
TYR A1200
ASN A1223
HIS A1224
TYR A1261
CYH A1273
CYH A1275
 None
SAM  A1301 (-3.6A)
None
SAM  A1301 (-3.8A)
SAM  A1301 (-3.9A)
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
ZN  A1304 (-2.3A)
 0.34A 3ooiA-6cenA:
32.8		 3ooiA-6cenA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 6 GLY A1156
TRP A1157
ASN A1223
HIS A1224
TYR A1261
CYH A1273
 SAM  A1301 (-3.6A)
None
SAM  A1301 (-3.2A)
None
SAM  A1301 (-4.9A)
ZN  A1304 ( 2.3A)
 1.14A 3ooiA-6cenA:
32.8		 3ooiA-6cenA:
76.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6cen HISTONE-LYSINE
N-METHYLTRANSFERASE
NSD3

(Homo sapiens) 		no annotation 5 GLY A1158
TYR A1200
HIS A1224
TYR A1261
CYH A1275
 None
SAM  A1301 (-3.9A)
None
SAM  A1301 (-4.9A)
ZN  A1304 (-2.3A)
 1.12A 3ooiA-6cenA:
32.8		 3ooiA-6cenA:
76.62