SIMILAR PATTERNS OF AMINO ACIDS FOR 3ONN_A_ACTA270_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		4 LEU A 338
SER A 334
LEU A 178
PRO A 179
 None
 0.96A 3onnA-1a2oA:
5.4		 3onnA-1a2oA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c39 CATION-DEPENDENT
MANNOSE-6-PHOSPHATE
RECEPTOR

(Bos taurus) 		PF02157
(Man-6-P_recep) 		4 LEU A 124
SER A 149
LEU A  29
PRO A  28
 None
 0.99A 3onnA-1c39A:
0.0		 3onnA-1c39A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hg4 ULTRASPIRACLE

(Drosophila
melanogaster) 		PF00104
(Hormone_recep) 		4 LEU A 490
ARG A 263
LEU A 487
PRO A 486
 None
 1.34A 3onnA-1hg4A:
undetectable		 3onnA-1hg4A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmv UNIVERSAL STRESS
PROTEIN A

(Haemophilus
influenzae) 		PF00582
(Usp) 		4 LEU A  72
SER A  75
LEU A  19
PRO A  16
 None
 1.25A 3onnA-1jmvA:
4.4		 3onnA-1jmvA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpf DIHYDROLIPOAMIDE
DEHYDROGENASE

(Pseudomonas
fluorescens) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 LEU A 231
SER A 197
ARG A 201
LEU A 193
 None
 1.16A 3onnA-1lpfA:
0.0		 3onnA-1lpfA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n71 AAC(6')-II

(Enterococcus
faecium) 		PF00583
(Acetyltransf_1) 		4 LEU A  20
SER A  80
ARG A  83
LEU A  23
 None
None
COA  A 601 (-3.6A)
None
 1.35A 3onnA-1n71A:
undetectable		 3onnA-1n71A:
23.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd4 AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Klebsiella
pneumoniae) 		PF01636
(APH) 		4 LEU A 103
SER A 105
LEU A 193
PRO A 194
 None
 1.37A 3onnA-1nd4A:
0.0		 3onnA-1nd4A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p65 NUCLEOCAPSID PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF01481
(Arteri_nucleo) 		4 LEU A  23
SER A  27
LEU A  55
PRO A  56
 None
 0.47A 3onnA-1p65A:
undetectable		 3onnA-1p65A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp0 VOLVATOXIN A2

(Volvariella
volvacea) 		PF01338
(Bac_thur_toxin) 		4 LEU A  25
SER A  21
LEU A 137
PRO A   9
 None
 1.13A 3onnA-1pp0A:
0.0		 3onnA-1pp0A:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rlf RLF

(Mus musculus) 		PF00788
(RA) 		4 LEU A 703
SER A 726
LEU A 704
PRO A 705
 None
 1.28A 3onnA-1rlfA:
undetectable		 3onnA-1rlfA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w93 ACETYL-COENZYME A
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 LEU A 384
SER A 360
LEU A 399
PRO A 400
 None
 1.26A 3onnA-1w93A:
3.7		 3onnA-1w93A:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
RE-EXPORTER

(Saccharomyces
cerevisiae) 		PF03378
(CAS_CSE1)
PF03810
(IBN_N)
PF08506
(Cse1) 		4 LEU C 638
SER C 641
LEU C 596
PRO C 593
 None
 1.18A 3onnA-1wa5C:
undetectable		 3onnA-1wa5C:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yks GENOME POLYPROTEIN
[CONTAINS:
FLAVIVIRIN PROTEASE
NS3 CATALYTIC
SUBUNIT]

(Yellow fever
virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 LEU A 243
ARG A 218
LEU A 213
PRO A 210
 None
 1.35A 3onnA-1yksA:
undetectable		 3onnA-1yksA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		4 LEU A 132
ARG A  87
LEU A  95
PRO A  94
 None
 1.30A 3onnA-2a35A:
3.1		 3onnA-2a35A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dx5 VACUOLAR PROTEIN
SORTING PROTEIN 36

(Mus musculus) 		PF11605
(Vps36_ESCRT-II) 		4 LEU A  47
SER A  43
LEU A  63
PRO A  62
 None
 1.23A 3onnA-2dx5A:
undetectable		 3onnA-2dx5A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g1k SHIKIMATE KINASE

(Mycobacterium
tuberculosis) 		PF01202
(SKI) 		4 LEU A 132
ARG A  58
LEU A  10
PRO A  11
 None
SKM  A 401 (-2.9A)
None
SO4  A 501 (-4.7A)
 1.12A 3onnA-2g1kA:
undetectable		 3onnA-2g1kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9i F420-0:GAMMA-GLUTAMY
L LIGASE

(Archaeoglobus
fulgidus) 		PF01996
(F420_ligase) 		4 LEU A  23
SER A  26
LEU A  11
PRO A  12
 None
 0.75A 3onnA-2g9iA:
undetectable		 3onnA-2g9iA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jii SERINE/THREONINE-PRO
TEIN KINASE VRK3
MOLECULE: VACCINIA
RELATED KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 278
SER A 282
LEU A 470
PRO A 471
 None
 1.30A 3onnA-2jiiA:
undetectable		 3onnA-2jiiA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mt9 FLAVODOXIN-2

(Escherichia
coli) 		PF00258
(Flavodoxin_1) 		4 LEU A  98
ARG A 156
LEU A 101
PRO A 131
 None
 1.34A 3onnA-2mt9A:
undetectable		 3onnA-2mt9A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ns6 MOBILIZATION PROTEIN
A

(Pseudomonas
aeruginosa) 		PF03389
(MobA_MobL) 		4 LEU A 181
ARG A 179
LEU A  83
PRO A  80
 None
 1.05A 3onnA-2ns6A:
undetectable		 3onnA-2ns6A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2own PUTATIVE
OLEOYL-[ACYL-CARRIER
PROTEIN]
THIOESTERASE

(Lactobacillus
plantarum) 		PF01643
(Acyl-ACP_TE) 		4 LEU A  50
ARG A  97
LEU A  48
PRO A 136
 None
UNL  A 268 (-4.1A)
None
None
 1.31A 3onnA-2ownA:
undetectable		 3onnA-2ownA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owo DNA LIGASE

(Escherichia
coli) 		PF01653
(DNA_ligase_aden)
PF03119
(DNA_ligase_ZBD)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 LEU A 176
SER A 206
LEU A 220
PRO A 219
 None
 1.24A 3onnA-2owoA:
undetectable		 3onnA-2owoA:
15.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oyr UPF0341 PROTEIN YHIQ

(Shigella
flexneri) 		PF04445
(SAM_MT) 		4 LEU A 203
SER A 154
LEU A 170
PRO A 172
 None
SAH  A 301 (-3.4A)
None
None
 1.08A 3onnA-2oyrA:
2.9		 3onnA-2oyrA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		4 LEU A 475
ARG A  55
LEU A  50
PRO A  47
 None
 1.19A 3onnA-2pggA:
undetectable		 3onnA-2pggA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qeu PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE

(Paraburkholderia
xenovorans) 		PF02627
(CMD) 		4 LEU A  31
SER A  46
LEU A  27
PRO A  28
 None
None
None
ACT  A 145 (-3.8A)
 1.34A 3onnA-2qeuA:
undetectable		 3onnA-2qeuA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qor GUANYLATE KINASE

(Plasmodium
vivax) 		PF00625
(Guanylate_kin) 		4 LEU A 132
ARG A 139
LEU A 154
PRO A  12
 None
POP  A 198 (-2.8A)
None
None
 1.17A 3onnA-2qorA:
undetectable		 3onnA-2qorA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vz9 FATTY ACID SYNTHASE

(Sus scrofa) 		PF00107
(ADH_zinc_N)
PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF08242
(Methyltransf_12)
PF08659
(KR)
PF14765
(PS-DH)
PF16197
(KAsynt_C_assoc) 		4 LEU A1140
SER A1218
LEU A1355
PRO A1354
 None
 1.22A 3onnA-2vz9A:
undetectable		 3onnA-2vz9A:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wb1 DNA-DIRECTED RNA
POLYMERASERPO3
SUBUNIT

(Sulfolobus
shibatae) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 LEU D  73
SER D  69
LEU D 147
PRO D  37
 None
 1.29A 3onnA-2wb1D:
undetectable		 3onnA-2wb1D:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wok CLAVULANIC ACID
BIOSYNTHESIS
OLIGOPEPTIDE BINDING
PROTEIN 2

(Streptomyces
clavuligerus) 		PF00496
(SBP_bac_5) 		4 LEU A 333
SER A 412
ARG A 415
LEU A 334
 None
 1.35A 3onnA-2wokA:
undetectable		 3onnA-2wokA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wya HYDROXYMETHYLGLUTARY
L-COA SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		4 LEU A 438
SER A 441
ARG A 116
LEU A 394
 None
 1.27A 3onnA-2wyaA:
undetectable		 3onnA-2wyaA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7c TYPE I RESTRICTION
ENZYME ECOKI M
PROTEIN

(Escherichia
coli) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 LEU B 257
ARG B 279
LEU B 215
PRO B 174
 None
 1.32A 3onnA-2y7cB:
undetectable		 3onnA-2y7cB:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		4 LEU A 238
SER A 210
LEU A 212
PRO A 213
 None
 1.31A 3onnA-2zoaA:
undetectable		 3onnA-2zoaA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		4 LEU A 907
SER A 904
LEU A 857
PRO A 858
 None
 1.29A 3onnA-3ak5A:
undetectable		 3onnA-3ak5A:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b79 TOXIN SECRETION
ATP-BINDING PROTEIN

(Vibrio
parahaemolyticus) 		PF03412
(Peptidase_C39) 		4 LEU A  40
ARG A  47
LEU A  31
PRO A  30
 None
 1.34A 3onnA-3b79A:
undetectable		 3onnA-3b79A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsf AT4G34840

(Arabidopsis
thaliana) 		PF01048
(PNP_UDP_1) 		4 LEU A 251
ARG A  11
LEU A  97
PRO A 203
 None
 1.33A 3onnA-3bsfA:
3.1		 3onnA-3bsfA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbx CD1-2 ANTIGEN

(Gallus gallus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 LEU A  43
SER A  71
ARG A  78
LEU A  50
 None
 1.16A 3onnA-3dbxA:
undetectable		 3onnA-3dbxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 LEU A 406
ARG A 409
LEU A 199
PRO A 198
 None
 1.37A 3onnA-3dwbA:
undetectable		 3onnA-3dwbA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 LEU A 142
ARG A 179
LEU A 108
PRO A 105
 None
 0.95A 3onnA-3eslA:
undetectable		 3onnA-3eslA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fk9 MUTATOR MUTT PROTEIN

(Bacillus
halodurans) 		PF00293
(NUDIX) 		4 LEU A 101
SER A  96
LEU A  18
PRO A  29
 None
 1.16A 3onnA-3fk9A:
undetectable		 3onnA-3fk9A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3flo DNA POLYMERASE ALPHA
SUBUNIT B

(Saccharomyces
cerevisiae) 		PF04042
(DNA_pol_E_B)
PF08418
(Pol_alpha_B_N) 		4 LEU A 442
SER A 445
LEU A 448
PRO A 449
 None
 1.26A 3onnA-3floA:
undetectable		 3onnA-3floA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2i ESTERASE

(Xanthomonas
oryzae) 		PF03583
(LIP) 		4 LEU A 139
SER A 141
LEU A 211
PRO A 208
 None
 1.03A 3onnA-3h2iA:
3.6		 3onnA-3h2iA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hr6 PUTATIVE
SURFACE-ANCHORED
FIMBRIAL SUBUNIT

(Corynebacterium
diphtheriae) 		no annotation 4 LEU A 344
ARG A 163
LEU A 326
PRO A 330
 None
 1.34A 3onnA-3hr6A:
undetectable		 3onnA-3hr6A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4x TRYPTOPHAN
DIMETHYLALLYLTRANSFE
RASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 LEU A 206
SER A 210
ARG A 213
LEU A 148
 None
 1.11A 3onnA-3i4xA:
undetectable		 3onnA-3i4xA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		4 LEU A1015
SER A1018
ARG A 675
LEU A 529
 None
 1.27A 3onnA-3jbyA:
2.9		 3onnA-3jbyA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jty BENF-LIKE PORIN

(Pseudomonas
protegens) 		PF03573
(OprD) 		4 LEU A  91
SER A  68
LEU A 156
PRO A 157
 None
 1.29A 3onnA-3jtyA:
undetectable		 3onnA-3jtyA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1h PUTATIVE
UNCHARACTERIZED
PROTEIN

(Helicobacter
pylori) 		PF16522
(FliS_cochap) 		4 LEU A  57
SER A  61
LEU A 128
PRO A 114
 None
 1.28A 3onnA-3k1hA:
undetectable		 3onnA-3k1hA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mb8 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Toxoplasma
gondii) 		PF01048
(PNP_UDP_1) 		4 LEU A 175
SER A 179
LEU A 214
PRO A 213
 None
None
None
IMH  A 280 (-4.1A)
 1.23A 3onnA-3mb8A:
2.7		 3onnA-3mb8A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne9 PHOSPHOPANTETHEINE
PROTEIN TRANSFERASE,
PPT1P

(Corynebacterium
ammoniagenes) 		PF01648
(ACPS) 		4 LEU A  38
SER A  36
LEU A 104
PRO A 105
 None
 1.26A 3onnA-3ne9A:
undetectable		 3onnA-3ne9A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ohm 1-PHOSPHATIDYLINOSIT
OL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU B 308
ARG B 826
LEU B 811
PRO B 812
 None
 1.37A 3onnA-3ohmB:
undetectable		 3onnA-3ohmB:
14.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3opx PROTEIN SSM1

(Saccharomyces
cerevisiae) 		PF13419
(HAD_2) 		4 LEU A  51
SER A  55
LEU A 108
PRO A 109
 None
 0.18A 3onnA-3opxA:
43.3		 3onnA-3opxA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 LEU A 372
SER A 327
ARG A 324
LEU A 315
 None
 1.33A 3onnA-3ps9A:
undetectable		 3onnA-3ps9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ps9 TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC

(Escherichia
coli) 		PF01266
(DAO)
PF05430
(Methyltransf_30) 		4 LEU A 376
ARG A 324
LEU A 372
PRO A 373
 None
 1.26A 3onnA-3ps9A:
undetectable		 3onnA-3ps9A:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r9b CYTOCHROME P450
164A2

(Mycolicibacterium
smegmatis) 		PF00067
(p450) 		4 LEU A 270
ARG A 405
LEU A 410
PRO A 396
 None
 1.37A 3onnA-3r9bA:
undetectable		 3onnA-3r9bA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd5 MYPAA.01249.C

(Mycobacterium
avium) 		PF00106
(adh_short) 		4 LEU A 289
SER A 186
LEU A 125
PRO A 126
 None
 1.31A 3onnA-3rd5A:
2.6		 3onnA-3rd5A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s46 ALANINE RACEMASE

(Streptococcus
pneumoniae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 207
SER A 229
LEU A 235
PRO A 236
 None
 1.25A 3onnA-3s46A:
undetectable		 3onnA-3s46A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6j HYDROLASE, HALOACID
DEHALOGENASE-LIKE
FAMILY

(Pseudomonas
syringae group
genomosp. 3) 		PF13419
(HAD_2) 		4 LEU A 155
SER A 159
ARG A 162
PRO A 249
 None
 1.19A 3onnA-3s6jA:
14.7		 3onnA-3s6jA:
26.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		4 LEU A 155
SER A 170
LEU A 151
PRO A 152
 None
 1.31A 3onnA-3vilA:
undetectable		 3onnA-3vilA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC

(Dictyostelium
discoideum) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 LEU A4290
SER A4720
LEU A4410
PRO A4411
 None
 1.23A 3onnA-3vkgA:
undetectable		 3onnA-3vkgA:
5.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arv PHYTASE

(Yersinia
kristensenii) 		PF00328
(His_Phos_2) 		4 LEU A 224
ARG A  17
LEU A 249
PRO A 327
 None
PO4  A1415 (-4.0A)
None
None
 1.36A 3onnA-4arvA:
undetectable		 3onnA-4arvA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7

(Mus musculus) 		PF06325
(PrmA) 		4 SER A 573
ARG A 604
LEU A 629
PRO A 632
 None
 1.16A 3onnA-4c4aA:
2.8		 3onnA-4c4aA:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e5t MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME, C-TERMINAL
DOMAIN PROTEIN

(Labrenzia
alexandrii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 190
ARG A 192
LEU A 226
PRO A 185
 None
 1.35A 3onnA-4e5tA:
undetectable		 3onnA-4e5tA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecd CHORISMATE SYNTHASE

(Bifidobacterium
longum) 		PF01264
(Chorismate_synt) 		4 LEU A 226
ARG A 312
LEU A 180
PRO A 181
 None
 1.37A 3onnA-4ecdA:
undetectable		 3onnA-4ecdA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fms PROBABLE PORIN

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B  66
SER B  43
LEU B 131
PRO B 132
 None
 1.35A 3onnA-4fmsB:
undetectable		 3onnA-4fmsB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp4 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		4 LEU A 143
SER A  82
LEU A 166
PRO A 165
 GER  A 301 ( 4.0A)
GER  A 301 (-4.5A)
None
None
 1.36A 3onnA-4fp4A:
undetectable		 3onnA-4fp4A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 LEU A 195
SER A 201
LEU A  94
PRO A  95
 LEU  A 195 (-0.6A)
SER  A 201 ( 0.0A)
LEU  A  94 ( 0.6A)
PRO  A  95 ( 1.1A)
 1.23A 3onnA-4g9kA:
undetectable		 3onnA-4g9kA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7o PUTATIVE SURFACE
CELL ANTIGEN SCA2

(Rickettsia
conorii) 		no annotation 4 LEU A 180
SER A 184
ARG A 187
LEU A 115
 None
 1.19A 3onnA-4j7oA:
undetectable		 3onnA-4j7oA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		4 LEU A 229
ARG A 362
LEU A  47
PRO A  48
 None
 1.17A 3onnA-4krgA:
undetectable		 3onnA-4krgA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lwo ARGININE
N-METHYLTRANSFERASE,
PUTATIVE

(Trypanosoma
brucei) 		no annotation 4 LEU B 271
SER B 274
LEU B 241
PRO B 190
 None
 1.26A 3onnA-4lwoB:
undetectable		 3onnA-4lwoB:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU A 201
ARG A 208
LEU A 179
PRO A 106
 None
 1.29A 3onnA-4p4sA:
2.5		 3onnA-4p4sA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p4s INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		4 LEU B 201
ARG B 208
LEU B 179
PRO B 106
 None
 1.29A 3onnA-4p4sB:
2.6		 3onnA-4p4sB:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 LEU B 308
ARG B 826
LEU B 811
PRO B 812
 None
 1.16A 3onnA-4qj4B:
undetectable		 3onnA-4qj4B:
15.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A2625
ARG A2631
LEU A2670
PRO A3144
 None
 1.29A 3onnA-4qyrA:
undetectable		 3onnA-4qyrA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlv ANKYRIN-1, ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4)
PF13857
(Ank_5) 		4 LEU A2336
SER A2334
ARG A2328
LEU A2351
 None
 1.36A 3onnA-4rlvA:
undetectable		 3onnA-4rlvA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		4 LEU A 260
ARG A 396
LEU A 401
PRO A 387
 None
 1.25A 3onnA-4tpnA:
undetectable		 3onnA-4tpnA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3v POLYKETIDE SYNTHASE
PKSR

(Bacillus
subtilis) 		PF14765
(PS-DH) 		4 LEU A 179
SER A 183
LEU A 163
PRO A 164
 None
 0.68A 3onnA-4u3vA:
undetectable		 3onnA-4u3vA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x6g OXYR

(Pseudomonas
aeruginosa) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 LEU A 227
SER A 241
LEU A 243
PRO A 244
 None
 1.13A 3onnA-4x6gA:
undetectable		 3onnA-4x6gA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzf BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF00955
(HCO3_cotransp) 		4 LEU A 677
SER A 725
LEU A 468
PRO A 467
 None
None
None
4KU  A1000 (-4.1A)
 1.15A 3onnA-4yzfA:
undetectable		 3onnA-4yzfA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z64 PHYTOSULFOKINE
RECEPTOR 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF13855
(LRR_8) 		4 LEU A 347
SER A 374
LEU A 332
PRO A 333
 None
 1.11A 3onnA-4z64A:
undetectable		 3onnA-4z64A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		4 LEU A  68
SER A  71
ARG A  75
LEU A 223
 None
 0.94A 3onnA-4zasA:
undetectable		 3onnA-4zasA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zq8 ISOPRENOID SYNTHASE

(Streptomyces
lydicus) 		no annotation 4 LEU A 238
SER A 318
LEU A 234
PRO A 235
 None
 1.19A 3onnA-4zq8A:
undetectable		 3onnA-4zq8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2o CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Francisella
tularensis) 		no annotation 4 LEU A 363
ARG A 102
LEU A 368
PRO A 367
 None
G  B  18 ( 3.4A)
None
CL  A1705 ( 3.9A)
 1.12A 3onnA-5b2oA:
undetectable		 3onnA-5b2oA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chl HISTONE H2A.Z

(Homo sapiens) 		PF00125
(Histone)
PF16211
(Histone_H2A_C) 		4 LEU B 173
ARG B  41
LEU B  71
PRO B  72
 None
 1.30A 3onnA-5chlB:
undetectable		 3onnA-5chlB:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d0f UNCHARACTERIZED
PROTEIN

([Candida]
glabrata) 		PF06202
(GDE_C)
PF14699
(hGDE_N)
PF14701
(hDGE_amylase)
PF14702
(hGDE_central) 		4 LEU A 143
SER A 584
LEU A 131
PRO A 132
 None
 1.27A 3onnA-5d0fA:
undetectable		 3onnA-5d0fA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd8 TRANSCRIPTIONAL
REGULATOR, MARR
FAMILY

(Deinococcus
radiodurans) 		PF12802
(MarR_2) 		4 LEU A  78
SER A  81
ARG A  80
LEU A  87
 None
None
CL  A 201 (-4.0A)
None
 1.34A 3onnA-5dd8A:
undetectable		 3onnA-5dd8A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dwd ESTERASE

(Pelagibacterium
halotolerans) 		PF02230
(Abhydrolase_2) 		4 LEU A 131
SER A 157
LEU A 135
PRO A 109
 None
 1.22A 3onnA-5dwdA:
4.6		 3onnA-5dwdA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e6k POLYKETIDE SYNTHASE
PKSL

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 LEU A  86
ARG A  92
LEU A 132
PRO A 591
 None
 1.34A 3onnA-5e6kA:
undetectable		 3onnA-5e6kA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fur TRANSCRIPTION
INITIATION FACTOR
TFIID SUBUNIT 7

(Homo sapiens) 		PF04658
(TAFII55_N) 		4 LEU H  63
SER H  65
LEU H  20
PRO H  21
 None
 1.29A 3onnA-5furH:
undetectable		 3onnA-5furH:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvv GLYCOSYL TRANSFERASE
FAMILY 8

(Streptococcus
pneumoniae) 		PF01501
(Glyco_transf_8) 		4 LEU A 226
ARG A 242
LEU A 222
PRO A 223
 None
 1.36A 3onnA-5gvvA:
undetectable		 3onnA-5gvvA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		4 LEU A  69
SER A  66
LEU A 322
PRO A 320
 None
 1.24A 3onnA-5jozA:
undetectable		 3onnA-5jozA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jy9 PUTATIVE SALICYLATE
SYNTHETASE

(Yersinia
enterocolitica) 		PF00425
(Chorismate_bind) 		4 LEU A 213
ARG A  25
LEU A  17
PRO A  18
 None
 1.27A 3onnA-5jy9A:
undetectable		 3onnA-5jy9A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l35 GENE 5 PROTEIN

(Shigella virus
Sf6) 		PF11651
(P22_CoatProtein) 		4 LEU A 120
ARG A  33
LEU A 404
PRO A 406
 None
 1.37A 3onnA-5l35A:
undetectable		 3onnA-5l35A:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vkq NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L

(Drosophila
melanogaster) 		PF00023
(Ank)
PF00520
(Ion_trans)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A1029
SER A1033
LEU A1014
PRO A1013
 None
 0.90A 3onnA-5vkqA:
undetectable		 3onnA-5vkqA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5whs CATALASE-PEROXIDASE

(Neurospora
crassa) 		no annotation 4 LEU A 236
SER A 231
ARG A 194
PRO A 119
 None
 1.36A 3onnA-5whsA:
undetectable		 3onnA-5whsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xd0 GLUCANASE

(Paenibacillus
sp. X4) 		PF01270
(Glyco_hydro_8) 		4 LEU A 254
SER A 259
LEU A 265
PRO A 266
 None
 1.03A 3onnA-5xd0A:
undetectable		 3onnA-5xd0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y4d ANKYRIN-1,ANKYRIN-2,
ANKYRIN-2

(Homo sapiens;
Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13637
(Ank_4) 		4 LEU A2336
SER A2334
ARG A2328
LEU A2351
 None
 1.19A 3onnA-5y4dA:
undetectable		 3onnA-5y4dA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z67 DNA REPLICATION AND
REPAIR PROTEIN RECF

(Caldanaerobacter
subterraneus) 		no annotation 4 LEU A 114
SER A  47
ARG A  44
PRO A 310
 None
 1.37A 3onnA-5z67A:
undetectable		 3onnA-5z67A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ze8 CYTOCHROME C552

(Thermochromatium
tepidum) 		no annotation 4 LEU A 422
ARG A 319
LEU A 418
PRO A  70
 None
HEM  A 502 ( 2.8A)
None
None
 1.32A 3onnA-5ze8A:
undetectable		 3onnA-5ze8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 4 LEU A 383
SER A 387
LEU A 284
PRO A 351
 None
 0.95A 3onnA-6a91A:
undetectable		 3onnA-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ape BIFUNCTIONAL PROTEIN
FOLD

(Helicobacter
pylori) 		PF00763
(THF_DHG_CYH)
PF02882
(THF_DHG_CYH_C) 		4 LEU A 134
SER A 140
LEU A 142
PRO A 143
 None
 1.16A 3onnA-6apeA:
undetectable		 3onnA-6apeA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et0 PQSB

(Pseudomonas
aeruginosa) 		no annotation 4 LEU B 238
ARG B 126
LEU B  10
PRO B  26
 None
 1.31A 3onnA-6et0B:
undetectable		 3onnA-6et0B:
undetectable