SIMILAR PATTERNS OF AMINO ACIDS FOR 3OLS_B_ESTB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 311
ALA A 313
LEU A 280
LEU A 278
ILE A  66
 None
 1.30A 3olsB-1a76A:
undetectable		 3olsB-1a76A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cp9 PENICILLIN G AMIDASE

(Providencia
rettgeri) 		PF01804
(Penicil_amidase) 		5 LEU B 298
LEU B 400
LEU B 401
ILE B 389
LEU B 351
 None
 1.21A 3olsB-1cp9B:
undetectable		 3olsB-1cp9B:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d2z DEATH DOMAIN OF TUBE

(Drosophila
melanogaster) 		PF14786
(Death_2) 		5 LEU B 141
ALA B 145
LEU B 133
LEU B 132
ILE B  60
 None
 1.25A 3olsB-1d2zB:
undetectable		 3olsB-1d2zB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dxx DYSTROPHIN

(Homo sapiens) 		PF00307
(CH) 		5 LEU A 110
LEU A  53
LEU A  54
ILE A  99
LEU A  40
 None
 1.20A 3olsB-1dxxA:
undetectable		 3olsB-1dxxA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		5 LEU A 148
LEU A 179
LEU A  53
ARG A  63
HIS A 136
 None
 1.21A 3olsB-1eg3A:
undetectable		 3olsB-1eg3A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzf COMPLEMENT FACTOR
C4A

(Homo sapiens) 		PF07678
(A2M_comp)
PF10569
(Thiol-ester_cl) 		5 LEU A1198
ALA A1202
MET A1262
LEU A1209
HIS A1256
 None
 1.27A 3olsB-1hzfA:
undetectable		 3olsB-1hzfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jlk RESPONSE REGULATOR
RCP1

(Synechocystis
sp. PCC 6803) 		PF00072
(Response_reg) 		5 LEU A  50
ALA A  48
LEU A  44
ILE A  65
LEU A  40
 None
 1.24A 3olsB-1jlkA:
undetectable		 3olsB-1jlkA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lox 15-LIPOXYGENASE

(Oryctolagus
cuniculus) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.21A 3olsB-1loxA:
undetectable		 3olsB-1loxA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nox NADH OXIDASE

(Thermus
thermophilus) 		PF00881
(Nitroreductase) 		5 LEU A  37
ALA A  39
LEU A 146
LEU A 147
ILE A  54
 None
 1.12A 3olsB-1noxA:
undetectable		 3olsB-1noxA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 ALA A 350
GLU A 353
LEU A 387
ARG A 394
ILE A 424
HIS A 524
LEU A 525
 EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 1.47A 3olsB-1pcgA:
32.9		 3olsB-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 ( 3.9A)
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.35A 3olsB-1pcgA:
32.9		 3olsB-1pcgA:
59.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1prz RIBOSOMAL LARGE
SUBUNIT
PSEUDOURIDINE
SYNTHASE D

(Escherichia
coli) 		PF00849
(PseudoU_synth_2) 		5 LEU A 284
ALA A 281
LEU A 138
ILE A 167
LEU A 228
 None
 1.29A 3olsB-1przA:
undetectable		 3olsB-1przA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhm PYRUVATE
FORMATE-LYASE

(Escherichia
coli) 		PF02901
(PFL-like) 		5 ALA A1554
GLU A1452
LEU A1443
ILE A1559
LEU A1470
 None
 1.03A 3olsB-1qhmA:
undetectable		 3olsB-1qhmA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sgv TRNA PSEUDOURIDINE
SYNTHASE B

(Mycobacterium
tuberculosis) 		PF01509
(TruB_N)
PF09142
(TruB_C)
PF16198
(TruB_C_2) 		5 ALA A 231
GLU A 230
LEU A 226
LEU A 224
LEU A  63
 None
 1.12A 3olsB-1sgvA:
undetectable		 3olsB-1sgvA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tnu GERANYLGERANYL
TRANSFERASE TYPE I
BETA SUBUNIT

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 MET B 233
LEU B 230
ALA B 228
LEU B 210
ILE B 197
 None
 1.21A 3olsB-1tnuB:
undetectable		 3olsB-1tnuB:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ugo BCL2-ASSOCIATED
ATHANOGENE 5

(Mus musculus) 		PF02179
(BAG) 		5 ALA A  79
GLU A  83
LEU A  57
LEU A  53
LEU A  20
 None
 1.10A 3olsB-1ugoA:
undetectable		 3olsB-1ugoA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vg0 RAB PROTEINS
GERANYLGERANYLTRANSF
ERASE COMPONENT A 1

(Rattus
norvegicus) 		PF00996
(GDI) 		5 LEU A 404
ALA A  85
GLU A  84
ARG A 411
ILE A 431
 None
 1.17A 3olsB-1vg0A:
undetectable		 3olsB-1vg0A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 ALA A  84
MET A 164
LEU A 200
LEU A 199
LEU A 217
 None
 1.23A 3olsB-1vhkA:
undetectable		 3olsB-1vhkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzo RIBOSOMAL PROTEIN S6
KINASE ALPHA 5

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 105
ALA A  35
LEU A 129
ILE A  88
HIS A  30
 None
 1.30A 3olsB-1vzoA:
undetectable		 3olsB-1vzoA:
21.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 324
GLU A 331
MET A 362
LEU A 365
ARG A 372
HIS A 494
 None
 0.62A 3olsB-1xb7A:
27.7		 3olsB-1xb7A:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 309
ARG A 316
ILE A 345
LEU A 436
 9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
 1.04A 3olsB-1xlsA:
25.2		 3olsB-1xlsA:
30.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7e PROTEIN ARNA

(Escherichia
coli) 		PF00551
(Formyl_trans_N)
PF01370
(Epimerase)
PF02911
(Formyl_trans_C) 		5 LEU A 165
ALA A 168
LEU A 148
HIS A 104
LEU A 103
 None
 1.29A 3olsB-1z7eA:
undetectable		 3olsB-1z7eA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4e 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
SEMIALDEHYDE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 LEU A 212
ALA A 215
GLU A 214
LEU A  98
ILE A 183
 None
 0.97A 3olsB-2d4eA:
undetectable		 3olsB-2d4eA:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e1a 75AA LONG
HYPOTHETICAL
REGULATORY PROTEIN
ASNC

(Pyrococcus
horikoshii) 		PF01037
(AsnC_trans_reg) 		5 MET A   8
LEU A  40
ALA A  31
LEU A  23
ILE A  66
 None
 1.19A 3olsB-2e1aA:
undetectable		 3olsB-2e1aA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ean CONNECTOR ENHANCER
OF KINASE SUPPRESSOR
OF RAS 2

(Homo sapiens) 		PF00536
(SAM_1) 		5 LEU A  67
ALA A  69
MET A  20
LEU A  23
LEU A  44
 None
 1.18A 3olsB-2eanA:
undetectable		 3olsB-2eanA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 MET A 117
LEU A 120
ALA A 124
LEU A 182
ILE A 234
 None
 1.08A 3olsB-2felA:
2.5		 3olsB-2felA:
21.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		7 LEU A 268
ALA A 272
GLU A 275
MET A 306
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.57A 3olsB-2gpvA:
27.5		 3olsB-2gpvA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbo DNA DC->DU-EDITING
ENZYME APOBEC-3G

(Homo sapiens) 		PF08210
(APOBEC_N) 		5 LEU A 138
GLU A 104
LEU A  70
ILE A 145
LEU A 117
 None
 1.23A 3olsB-2kboA:
undetectable		 3olsB-2kboA:
19.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 346
ALA A 350
GLU A 353
LEU A 387
MET A 388
LEU A 391
ARG A 394
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 ( 4.6A)
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.43A 3olsB-2ocfA:
33.4		 3olsB-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		5 LEU A  95
LEU A  22
LEU A  23
ILE A  57
LEU A  37
 None
 1.18A 3olsB-2p35A:
undetectable		 3olsB-2p35A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3y ANCESTRAL CORTICIOD
RECEPTOR

(unidentified) 		PF00104
(Hormone_recep) 		5 LEU A  32
ALA A  36
MET A  70
LEU A  77
ARG A  80
 1CA  A 247 (-4.0A)
1CA  A 247 (-3.6A)
1CA  A 247 ( 3.8A)
1CA  A 247 ( 3.9A)
1CA  A 247 (-3.8A)
 0.34A 3olsB-2q3yA:
28.3		 3olsB-2q3yA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvl DIACYLGLYCEROL
KINASE DGKB

(Staphylococcus
aureus) 		PF00781
(DAGK_cat) 		5 ALA A 280
LEU A 268
LEU A 266
ILE A 223
LEU A 196
 None
 1.09A 3olsB-2qvlA:
undetectable		 3olsB-2qvlA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3acz METHIONINE
GAMMA-LYASE

(Entamoeba
histolytica) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 330
LEU A 339
LEU A 333
ARG A 367
ILE A 214
 None
None
LLP  A 205 ( 4.3A)
SO4  A2001 (-2.9A)
LLP  A 205 ( 4.5A)
 1.30A 3olsB-3aczA:
undetectable		 3olsB-3aczA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 GLU A 894
LEU A 776
ARG A 505
ILE A 878
LEU A 932
 None
 1.19A 3olsB-3dy5A:
undetectable		 3olsB-3dy5A:
13.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ear HERA

(Thermus
thermophilus) 		PF00271
(Helicase_C) 		5 MET A 242
LEU A 292
GLU A 252
LEU A 272
ILE A 304
 None
 1.07A 3olsB-3earA:
undetectable		 3olsB-3earA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ego PROBABLE
2-DEHYDROPANTOATE
2-REDUCTASE

(Bacillus
subtilis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ALA A 217
GLU A 216
LEU A 280
LEU A 283
LEU A 180
 None
 1.29A 3olsB-3egoA:
undetectable		 3olsB-3egoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hh8 METAL ABC
TRANSPORTER
SUBSTRATE-BINDING
LIPOPROTEIN

(Streptococcus
pyogenes) 		PF01297
(ZnuA) 		5 ALA A 187
GLU A 186
LEU A 300
MET A 296
ILE A 148
 None
 1.29A 3olsB-3hh8A:
undetectable		 3olsB-3hh8A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 LEU A 671
ALA A 568
LEU A 664
LEU A 665
ILE A 369
 None
 1.19A 3olsB-3htxA:
undetectable		 3olsB-3htxA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9y SENSOR PROTEIN

(Vibrio
parahaemolyticus) 		no annotation 5 LEU A 126
GLU A 128
LEU A 295
ILE A  65
LEU A  72
 None
 1.28A 3olsB-3i9yA:
undetectable		 3olsB-3i9yA:
25.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kn1 GOLGI PHOSPHOPROTEIN
3

(Homo sapiens) 		PF05719
(GPP34) 		5 LEU A 133
ALA A 136
GLU A 135
LEU A 170
LEU A  94
 None
 1.17A 3olsB-3kn1A:
undetectable		 3olsB-3kn1A:
23.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		5 LEU A  16
MET A  17
LEU A  20
ARG A  23
LEU A 128
 None
 1.24A 3olsB-3kyeA:
undetectable		 3olsB-3kyeA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn3 CARBON
CATABOLITE-DEREPRESS
ING PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		5 LEU A 282
ALA A 279
LEU A 246
MET A 245
ILE A 162
 None
 1.31A 3olsB-3mn3A:
undetectable		 3olsB-3mn3A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 LEU B 375
ALA B 378
LEU B 408
HIS B 575
LEU B 539
 None
 1.17A 3olsB-3p8cB:
undetectable		 3olsB-3p8cB:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pt1 UPF0364 PROTEIN
YMR027W

(Saccharomyces
cerevisiae) 		PF01937
(DUF89) 		5 LEU A 264
ALA A 262
GLU A 259
LEU A 253
ILE A 340
 None
 1.26A 3olsB-3pt1A:
undetectable		 3olsB-3pt1A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ALA A 170
GLU A 169
LEU A 158
ARG A 163
LEU A 119
 None
 1.28A 3olsB-3q0gA:
undetectable		 3olsB-3q0gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rde ARACHIDONATE
12-LIPOXYGENASE,
12S-TYPE

(Sus scrofa) 		PF00305
(Lipoxygenase) 		5 LEU A 358
ALA A 433
LEU A 281
LEU A 282
HIS A 356
 None
 1.13A 3olsB-3rdeA:
undetectable		 3olsB-3rdeA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sl5 CAMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE 4D

(Homo sapiens) 		PF00233
(PDEase_I) 		5 MET A 286
LEU A 283
LEU A 279
ILE A 307
LEU A 300
 MET  A 286 ( 0.0A)
LEU  A 283 ( 0.6A)
LEU  A 279 ( 0.6A)
ILE  A 307 ( 0.4A)
LEU  A 300 ( 0.6A)
 1.18A 3olsB-3sl5A:
undetectable		 3olsB-3sl5A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		5 MET A  48
LEU A  30
LEU A   5
LEU A   7
ILE A  74
 None
 1.17A 3olsB-3slcA:
undetectable		 3olsB-3slcA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 LEU A 222
ALA A 113
GLU A 116
ARG A 234
LEU A 187
 LEU  A 222 ( 0.6A)
ALA  A 113 ( 0.0A)
GLU  A 116 ( 0.5A)
ARG  A 234 ( 0.6A)
LEU  A 187 ( 0.5A)
 1.17A 3olsB-3wd7A:
undetectable		 3olsB-3wd7A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wme ATP-BINDING
CASSETTE, SUB-FAMILY
B, MEMBER 1

(Cyanidioschyzon
merolae) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 558
ALA A 561
GLU A 560
LEU A 600
ILE A 538
 None
 1.31A 3olsB-3wmeA:
undetectable		 3olsB-3wmeA:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a14 KINESIN-LIKE PROTEIN
KIF7

(Homo sapiens) 		PF00225
(Kinesin) 		5 MET A 101
ALA A 120
GLU A 123
LEU A  76
ILE A 320
 None
 0.91A 3olsB-4a14A:
undetectable		 3olsB-4a14A:
23.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		5 LEU A 264
ALA A 267
LEU A 198
LEU A 196
ILE A 126
 None
 1.06A 3olsB-4bs9A:
undetectable		 3olsB-4bs9A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1k THROMBOSPONDIN
RELATED ANONYMOUS
PROTEIN

(Plasmodium
falciparum) 		PF00092
(VWA) 		5 MET A  53
LEU A  51
LEU A  79
ILE A 118
LEU A  71
 None
 1.28A 3olsB-4f1kA:
undetectable		 3olsB-4f1kA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4flc ADENYLOSUCCINATE
LYASE

(Homo sapiens) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		5 LEU A 142
ALA A 146
GLU A 148
LEU A 362
ILE A 265
 None
 1.05A 3olsB-4flcA:
2.4		 3olsB-4flcA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		5 MET A 339
ALA A 346
MET A 304
LEU A 307
ILE A 323
 None
 1.10A 3olsB-4g3jA:
undetectable		 3olsB-4g3jA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i6k AMIDOHYDROLASE
FAMILY PROTEIN

(Acinetobacter
baumannii) 		PF04909
(Amidohydro_2) 		5 LEU A  64
ALA A  62
LEU A  56
ILE A  97
LEU A  50
 None
 1.02A 3olsB-4i6kA:
undetectable		 3olsB-4i6kA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 433
LEU A 428
ARG A 338
ILE A 439
LEU A 443
 None
 1.24A 3olsB-4i8vA:
undetectable		 3olsB-4i8vA:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j5x RETINOIC ACID
RECEPTOR RXR-ALPHA,
NUCLEAR RECEPTOR
COACTIVATOR 1

(Homo sapiens) 		no annotation 5 ALA D 272
LEU D 309
ARG D 316
ILE D 345
LEU D 436
 None
 1.03A 3olsB-4j5xD:
24.4		 3olsB-4j5xD:
28.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lnz UNCONVENTIONAL
MYOSIN-VB

(Homo sapiens) 		PF01843
(DIL) 		5 MET A1737
LEU A1740
ALA A1744
LEU A1622
ILE A1689
 None
 1.13A 3olsB-4lnzA:
undetectable		 3olsB-4lnzA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mhc NUCLEOPORIN NUP157

(Saccharomyces
cerevisiae) 		PF08801
(Nucleoporin_N) 		5 LEU A 798
ALA A 794
GLU A 791
LEU A 705
ILE A 716
 None
 1.26A 3olsB-4mhcA:
undetectable		 3olsB-4mhcA:
15.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 283
ALA A 287
GLU A 290
MET A 321
LEU A 324
ARG A 331
 None
 0.38A 3olsB-4n1yA:
30.8		 3olsB-4n1yA:
38.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nee AP-2 COMPLEX SUBUNIT
ALPHA-2

(Rattus
norvegicus) 		no annotation 5 MET G 353
ALA G 389
LEU G 377
HIS G 369
LEU G 338
 None
 1.09A 3olsB-4neeG:
undetectable		 3olsB-4neeG:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2w E3 UBIQUITIN-PROTEIN
LIGASE HERC1

(Homo sapiens) 		PF00415
(RCC1) 		5 LEU A4306
ALA A4357
LEU A4340
ILE A4293
LEU A4304
 None
 1.31A 3olsB-4o2wA:
undetectable		 3olsB-4o2wA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
 None
 1.25A 3olsB-4q5nA:
undetectable		 3olsB-4q5nA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ro5 SAT DOMAIN FROM CAZM

(Chaetomium
globosum) 		PF16073
(SAT) 		5 LEU A 338
ALA A 336
LEU A 158
LEU A 159
ILE A 191
 None
 1.08A 3olsB-4ro5A:
undetectable		 3olsB-4ro5A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rye D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Mycobacterium
tuberculosis) 		PF00768
(Peptidase_S11) 		5 ALA A  79
GLU A  82
LEU A 136
ILE A  71
LEU A 120
 None
 1.08A 3olsB-4ryeA:
undetectable		 3olsB-4ryeA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1v D-3-PHOSPHOGLYCERATE
DEHYDROGENASE-RELATE
D PROTEIN

(Vibrio cholerae) 		no annotation 5 LEU D 149
ALA D 202
LEU D 232
ARG D 142
ILE D 161
 None
 1.31A 3olsB-4s1vD:
undetectable		 3olsB-4s1vD:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udb MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 769
ALA A 773
MET A 807
LEU A 810
LEU A 814
ARG A 817
 CV7  A1987 (-4.1A)
CV7  A1987 (-3.5A)
CV7  A1987 ( 3.9A)
CV7  A1987 (-4.0A)
CV7  A1987 ( 4.0A)
CV7  A1987 (-3.7A)
 0.47A 3olsB-4udbA:
27.4		 3olsB-4udbA:
27.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uhi STEROL 14-ALPHA
DEMETHYLASE

(Homo sapiens) 		PF00067
(p450) 		5 LEU A 305
LEU A 296
LEU A 286
ARG A 272
LEU A 159
 None
None
None
None
VFV  A 580 (-4.5A)
 1.29A 3olsB-4uhiA:
undetectable		 3olsB-4uhiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utg SUGAR KINASE

(Burkholderia
pseudomallei) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 LEU A 133
ALA A 129
LEU A 136
ILE A 100
LEU A 104
 None
 1.17A 3olsB-4utgA:
undetectable		 3olsB-4utgA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzw PUMILIO
DOMAIN-CONTAINING
PROTEIN KIAA0020

(Homo sapiens) 		PF08144
(CPL) 		5 LEU A 490
ALA A 518
LEU A 483
LEU A 445
ILE A 426
 None
 1.16A 3olsB-4wzwA:
undetectable		 3olsB-4wzwA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgu PUTATIVE PACHYTENE
CHECKPOINT PROTEIN 2

(Caenorhabditis
elegans) 		PF00004
(AAA) 		5 LEU A 411
ALA A 415
GLU A 418
LEU A 393
ILE A 403
 None
 0.94A 3olsB-4xguA:
undetectable		 3olsB-4xguA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ybq SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 5

(Rattus
norvegicus) 		PF00083
(Sugar_tr) 		5 LEU A 233
ALA A 232
LEU A 219
LEU A 220
LEU A 152
 None
 1.09A 3olsB-4ybqA:
undetectable		 3olsB-4ybqA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0t RIBONUCLEASE J

(Streptomyces
coelicolor) 		PF00753
(Lactamase_B)
PF07521
(RMMBL) 		5 MET A 321
LEU A 318
ALA A 316
GLU A 313
ILE A 237
 None
None
C  E   3 ( 3.4A)
C  E   2 ( 3.8A)
None
 1.12A 3olsB-5a0tA:
undetectable		 3olsB-5a0tA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a21 PORTAL PROTEIN

(Bacillus phage
SPP1) 		PF05133
(Phage_prot_Gp6) 		5 LEU A 199
ALA A 197
MET A 165
LEU A  37
HIS A 146
 None
 1.21A 3olsB-5a21A:
undetectable		 3olsB-5a21A:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dx5 METHIONINE
GAMMA-LYASE

(Clostridium
sporogenes) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 339
LEU A 348
LEU A 342
ARG A 376
ILE A 221
 None
None
None
None
PLP  A 501 ( 4.8A)
 1.31A 3olsB-5dx5A:
undetectable		 3olsB-5dx5A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e4y HOMOSERINE
O-ACETYLTRANSFERASE

(Pseudomonas
veronii) 		PF00561
(Abhydrolase_1) 		5 LEU A 336
MET A 332
LEU A 333
ARG A  72
HIS A 322
 None
 1.25A 3olsB-5e4yA:
undetectable		 3olsB-5e4yA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyq NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-2

(Homo sapiens) 		PF02146
(SIR2) 		5 LEU A 331
LEU A 154
LEU A 155
ILE A 285
LEU A 329
 None
 1.20A 3olsB-5fyqA:
undetectable		 3olsB-5fyqA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g4i PHOSPHOLYASE

(Paenarthrobacter
aurescens) 		PF00202
(Aminotran_3) 		5 LEU A 128
ALA A 131
LEU A 247
ILE A 157
HIS A 170
 None
 1.20A 3olsB-5g4iA:
undetectable		 3olsB-5g4iA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hj7 GLUTAMATE RACEMASE

(Mycobacterium
tuberculosis) 		PF01177
(Asp_Glu_race) 		5 GLU A 239
LEU A  63
ARG A  66
ILE A  24
LEU A  18
 None
 1.26A 3olsB-5hj7A:
undetectable		 3olsB-5hj7A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hw3 BETA-LACTAMASE

(Burkholderia
vietnamiensis) 		PF13354
(Beta-lactamase2) 		5 LEU A  75
ALA A  77
MET A 210
LEU A 128
ILE A 185
 None
 1.23A 3olsB-5hw3A:
undetectable		 3olsB-5hw3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijw GLUTAMATE RACEMASE

(Mycolicibacterium
smegmatis) 		PF01177
(Asp_Glu_race) 		5 GLU A 243
LEU A  63
ARG A  66
ILE A  24
LEU A  18
 None
 1.26A 3olsB-5ijwA:
undetectable		 3olsB-5ijwA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1g PLECTIN

(Homo sapiens) 		no annotation 5 LEU A1070
ALA A1074
LEU A1090
ILE A1019
LEU A1098
 None
 1.15A 3olsB-5j1gA:
undetectable		 3olsB-5j1gA:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jhq TANKYRASE-1

(Homo sapiens) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13606
(Ank_3) 		5 LEU A 267
LEU A 269
ILE A 251
HIS A 221
LEU A 220
 None
 1.24A 3olsB-5jhqA:
undetectable		 3olsB-5jhqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0w SEC71

(Chaetomium
thermophilum) 		PF09802
(Sec66) 		5 LEU A  63
ALA A  62
LEU A  39
LEU A  40
HIS A  30
 None
 1.31A 3olsB-5l0wA:
undetectable		 3olsB-5l0wA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3)
PF00507
(Oxidored_q4) 		5 LEU K  73
ALA K  71
LEU A  63
LEU A  64
ILE J 171
 None
 1.00A 3olsB-5lc5K:
undetectable		 3olsB-5lc5K:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m49 AMINOTRANSFERASE
CLASS-III

(Rhizobium
freirei) 		PF00202
(Aminotran_3) 		5 LEU A 414
ALA A 418
GLU A 421
ILE A  43
LEU A 385
 None
 1.13A 3olsB-5m49A:
undetectable		 3olsB-5m49A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 6 MET G 202
LEU G 219
ALA G 223
LEU G 177
MET G 176
ILE G 428
 None
 1.06A 3olsB-5mlvG:
undetectable		 3olsB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mwp MINERALOCORTICOID
RECEPTOR

(Homo sapiens) 		no annotation 5 LEU A 769
ALA A 773
MET A 807
LEU A 814
ARG A 817
 ECV  A1101 (-4.7A)
ECV  A1101 (-3.8A)
ECV  A1101 (-3.6A)
ECV  A1101 (-4.1A)
ECV  A1101 (-4.0A)
 0.34A 3olsB-5mwpA:
27.5		 3olsB-5mwpA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nii THIOREDOXIN
REDUCTASE

(Desulfovibrio
vulgaris) 		no annotation 5 LEU A 223
ALA A 220
GLU A 218
ARG A 196
ILE A 225
 None
 1.18A 3olsB-5niiA:
undetectable		 3olsB-5niiA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 5 LEU A 245
ALA A 414
LEU A 255
MET A 256
LEU A 447
 None
 1.26A 3olsB-5oltA:
undetectable		 3olsB-5oltA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		12 MET A 295
LEU A 298
ALA A 302
GLU A 305
MET A 336
LEU A 339
MET A 340
LEU A 343
ARG A 346
ILE A 373
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
None
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.42A 3olsB-5toaA:
33.1		 3olsB-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqw INHIBITOR OF NUCLEAR
FACTOR KAPPA-B
KINASE SUBUNIT ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 LEU A 537
ALA A 539
GLU A 543
LEU A 544
ILE A 618
 None
 1.27A 3olsB-5tqwA:
undetectable		 3olsB-5tqwA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2l HEAT SHOCK PROTEIN
104

(Candida
albicans) 		PF02861
(Clp_N) 		5 LEU A  33
ALA A  35
LEU A  49
ILE A 127
LEU A  71
 None
 1.24A 3olsB-5u2lA:
undetectable		 3olsB-5u2lA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ulj RAI1

(Scheffersomyces
stipitis) 		PF08652
(RAI1) 		5 MET A 111
MET A  80
LEU A  83
ILE A 104
LEU A 127
 None
 1.11A 3olsB-5uljA:
undetectable		 3olsB-5uljA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 5 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 3olsB-5vrdD:
undetectable		 3olsB-5vrdD:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xav INTRACELLULAR
POLYHYDROXYALKANOATE
SYNTHASE

(Chromobacterium
sp. USM2) 		PF07167
(PhaC_N) 		5 LEU A 338
ALA A 340
MET A 346
ILE A 352
HIS A 404
 None
 1.29A 3olsB-5xavA:
undetectable		 3olsB-5xavA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 ALA A  76
MET A 338
LEU A 341
ARG A 196
HIS A 281
 None
RFH  A 502 ( 3.9A)
RFH  A 502 (-4.4A)
RFH  A 502 (-3.1A)
None
 1.27A 3olsB-6c7sA:
undetectable		 3olsB-6c7sA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 5 GLU C 131
LEU C 294
ARG C 297
ILE C 199
LEU C 235
 None
 1.24A 3olsB-6fkhC:
undetectable		 3olsB-6fkhC:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gdt -

(-) 		no annotation 5 LEU A 309
ALA A 257
LEU A 171
ARG A 263
ILE A 369
 None
 1.31A 3olsB-6gdtA:
undetectable		 3olsB-6gdtA:
undetectable