SIMILAR PATTERNS OF AMINO ACIDS FOR 3OLS_A_ESTA600
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a2v | METHYLAMINE OXIDASE (Ogataea angusta) |
PF01179(Cu_amine_oxid)PF02727(Cu_amine_oxidN2)PF02728(Cu_amine_oxidN3) | 5 | ALA A 440GLU A 438ARG A 213GLY A 306HIS A 456 | NoneNoneNoneNone CU A 1 (-3.3A) | 1.09A | 3olsA-1a2vA:undetectable | 3olsA-1a2vA:17.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h39 | SQUALENE--HOPENECYCLASE (Alicyclobacillusacidocaldarius) |
PF13243(SQHop_cyclase_C)PF13249(SQHop_cyclase_N) | 5 | LEU A 319LEU A 316ALA A 317GLY A 337LEU A 333 | None | 1.09A | 3olsA-1h39A:undetectable | 3olsA-1h39A:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i0a | DELTA CRYSTALLIN I (Meleagrisgallopavo) |
PF00206(Lyase_1)PF14698(ASL_C2) | 5 | MET A 250LEU A 253LEU A 256ALA A 257LEU A 293 | None | 0.94A | 3olsA-1i0aA:0.2 | 3olsA-1i0aA:21.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1khy | CLPB PROTEIN (Escherichiacoli) |
PF02861(Clp_N) | 5 | LEU A 110LEU A 113ALA A 114GLU A 117LEU A 93 | None | 0.87A | 3olsA-1khyA:undetectable | 3olsA-1khyA:22.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ldd | ANAPHASE PROMOTINGCOMPLEX (Saccharomycescerevisiae) |
PF08672(ANAPC2) | 5 | LEU A 826LEU A 829ALA A 830LEU A 789GLY A 841 | None | 0.98A | 3olsA-1lddA:undetectable | 3olsA-1lddA:24.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lqa | TAS PROTEIN (Escherichiacoli) |
PF00248(Aldo_ket_red) | 5 | ALA A 85LEU A 82ARG A 79GLY A 17LEU A 306 | NoneNoneNoneNoneNDP A1400 (-4.2A) | 1.03A | 3olsA-1lqaA:undetectable | 3olsA-1lqaA:22.29 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 342LEU A 346LEU A 349GLU A 353LEU A 391ARG A 394 | NoneEST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 (-2.8A)EST A 1 ( 3.9A)EST A 1 (-3.7A) | 1.45A | 3olsA-1pcgA:33.2 | 3olsA-1pcgA:59.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1pcg | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | MET A 343LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387LEU A 391ARG A 394GLY A 521HIS A 524LEU A 525 | EST A 1 ( 4.0A)EST A 1 (-4.4A)EST A 1 ( 4.8A)EST A 1 ( 3.7A)EST A 1 (-2.8A)EST A 1 (-4.0A)EST A 1 ( 3.9A)EST A 1 (-3.7A)EST A 1 ( 4.1A)EST A 1 (-3.8A)EST A 1 (-3.6A) | 0.39A | 3olsA-1pcgA:33.2 | 3olsA-1pcgA:59.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxy | FIMBRIN-LIKE PROTEIN (Arabidopsisthaliana) |
PF00307(CH) | 5 | LEU A 612LEU A 553LEU A 554GLY A 547LEU A 544 | None | 1.00A | 3olsA-1pxyA:0.0 | 3olsA-1pxyA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q5q | PROTEASOMEALPHA-TYPE SUBUNIT 1 (Rhodococcuserythropolis) |
PF00227(Proteasome) | 5 | MET A 13LEU A 19ALA A 20GLU A 119GLY A 108 | None | 0.97A | 3olsA-1q5qA:undetectable | 3olsA-1q5qA:20.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ugo | BCL2-ASSOCIATEDATHANOGENE 5 (Mus musculus) |
PF02179(BAG) | 5 | ALA A 79GLU A 83LEU A 57LEU A 53LEU A 20 | None | 1.12A | 3olsA-1ugoA:undetectable | 3olsA-1ugoA:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhk | HYPOTHETICAL PROTEINYQEU (Bacillussubtilis) |
PF04452(Methyltrans_RNA) | 6 | ALA A 84MET A 164LEU A 200LEU A 199GLY A 222LEU A 217 | None | 1.28A | 3olsA-1vhkA:undetectable | 3olsA-1vhkA:21.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x9s | DNA POLYMERASE (Escherichiavirus T7) |
PF00476(DNA_pol_A) | 5 | LEU A 481LEU A 484ALA A 485GLY A 503LEU A 501 | None | 0.93A | 3olsA-1x9sA:undetectable | 3olsA-1x9sA:16.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1xb7 | STEROID HORMONERECEPTOR ERR1 (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 324LEU A 327GLU A 331MET A 362LEU A 365ARG A 372HIS A 494 | None | 0.61A | 3olsA-1xb7A:28.5 | 3olsA-1xb7A:34.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y7i | SALICYLICACID-BINDING PROTEIN2 (Nicotianatabacum) |
PF12697(Abhydrolase_6) | 5 | LEU A 82ALA A 106LEU A 119GLY A 88LEU A 87 | SAL A 501 (-3.9A)NoneNoneNoneNone | 1.12A | 3olsA-1y7iA:undetectable | 3olsA-1y7iA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zh8 | OXIDOREDUCTASE (Thermotogamaritima) |
PF01408(GFO_IDH_MocA)PF02894(GFO_IDH_MocA_C) | 5 | LEU A 305LEU A 308ALA A 309GLU A 312LEU A 327 | None | 1.09A | 3olsA-1zh8A:undetectable | 3olsA-1zh8A:19.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2gpv | ESTROGEN-RELATEDRECEPTOR GAMMA (Homo sapiens) |
PF00104(Hormone_recep) | 8 | LEU A 268LEU A 271ALA A 272GLU A 275MET A 306LEU A 309ARG A 316HIS A 434 | OHT A 500 (-4.1A)OHT A 500 ( 4.4A)OHT A 500 (-3.5A)OHT A 500 (-2.6A)OHT A 500 (-3.9A)OHT A 500 ( 4.0A)OHT A 500 (-3.8A)OHT A 500 ( 4.7A) | 0.53A | 3olsA-2gpvA:27.8 | 3olsA-2gpvA:37.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jug | TUBC PROTEIN (Archangiumdisciforme) |
no annotation | 5 | LEU A 52ALA A 54LEU A 11LEU A 10GLY A 18 | None | 1.04A | 3olsA-2jugA:undetectable | 3olsA-2jugA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oce | HYPOTHETICAL PROTEINPA5201 (Pseudomonasaeruginosa) |
PF00575(S1)PF09371(Tex_N)PF12836(HHH_3)PF16921(Tex_YqgF) | 6 | LEU A 127LEU A 130ALA A 131LEU A 170GLY A 119LEU A 123 | None | 1.26A | 3olsA-2oceA:undetectable | 3olsA-2oceA:15.23 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 342LEU A 346LEU A 349GLU A 353LEU A 391ARG A 394 | NoneEST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 (-2.7A)EST A 596 ( 4.6A)EST A 596 (-4.0A) | 1.50A | 3olsA-2ocfA:34.0 | 3olsA-2ocfA:57.71 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ocf | ESTROGEN RECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 11 | MET A 343LEU A 346LEU A 349ALA A 350GLU A 353LEU A 387LEU A 391ARG A 394GLY A 521HIS A 524LEU A 525 | EST A 596 (-4.8A)EST A 596 (-4.4A)EST A 596 ( 4.1A)EST A 596 ( 3.9A)EST A 596 (-2.7A)EST A 596 ( 4.2A)EST A 596 ( 4.6A)EST A 596 (-4.0A)EST A 596 ( 4.0A)EST A 596 (-4.2A)EST A 596 (-3.6A) | 0.44A | 3olsA-2ocfA:34.0 | 3olsA-2ocfA:57.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ook | HYPOTHETICAL PROTEIN (Shewanellafrigidimarina) |
PF11964(SpoIIAA-like) | 5 | LEU A 124LEU A 121ALA A 120GLU A 117LEU A 90 | None | 1.13A | 3olsA-2ookA:undetectable | 3olsA-2ookA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pet | LUTHERAN BLOOD GROUPGLYCOPROTEIN (Homo sapiens) |
PF07686(V-set)PF08205(C2-set_2) | 5 | LEU A 4ALA A 104LEU A 33GLY A 99HIS A 28 | None | 1.10A | 3olsA-2petA:undetectable | 3olsA-2petA:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2q3y | ANCESTRAL CORTICIODRECEPTOR (unidentified) |
PF00104(Hormone_recep) | 6 | LEU A 32LEU A 35ALA A 36MET A 70LEU A 77ARG A 80 | 1CA A 247 (-4.0A)1CA A 247 ( 4.4A)1CA A 247 (-3.6A)1CA A 247 ( 3.8A)1CA A 247 ( 3.9A)1CA A 247 (-3.8A) | 0.35A | 3olsA-2q3yA:29.2 | 3olsA-2q3yA:29.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rk0 | GLYOXALASE/BLEOMYCINRESISTANCEPROTEIN/DIOXYGENASEDOMAIN (Frankia sp.EAN1pec) |
PF00903(Glyoxalase) | 5 | LEU A 76LEU A 122ALA A 121LEU A 11GLY A 72 | None | 1.01A | 3olsA-2rk0A:undetectable | 3olsA-2rk0A:22.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnt | RIBOSOMAL PROTEIN S6KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 512LEU A 603GLY A 610HIS A 688LEU A 686 | None | 1.06A | 3olsA-2wntA:undetectable | 3olsA-2wntA:20.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3byh | FIMBRIN ABD2 (Homo sapiens) |
PF00307(CH) | 5 | LEU B 612LEU B 553LEU B 554GLY B 547LEU B 544 | None | 1.01A | 3olsA-3byhB:undetectable | 3olsA-3byhB:21.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dv9 | BETA-PHOSPHOGLUCOMUTASE (Bacteroidesvulgatus) |
PF13419(HAD_2) | 5 | LEU A 183MET A 125LEU A 122GLY A 175LEU A 172 | None | 1.12A | 3olsA-3dv9A:undetectable | 3olsA-3dv9A:22.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e02 | UNCHARACTERIZEDPROTEIN DUF849 (Paraburkholderiaxenovorans) |
PF05853(BKACE) | 5 | ALA A 99LEU A 94ARG A 156GLY A 89HIS A 51 | NoneEDO A 320 (-4.5A)EDO A 320 (-4.5A)None ZN A 311 (-3.4A) | 1.12A | 3olsA-3e02A:undetectable | 3olsA-3e02A:21.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e3b | CASEIN KINASE IISUBUNIT ALPHA' (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA X 319GLU X 318LEU X 314ARG X 11GLY X 220 | None | 1.06A | 3olsA-3e3bX:undetectable | 3olsA-3e3bX:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ee4 | PROBABLERIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Mycobacteriumtuberculosis) |
PF00268(Ribonuc_red_sm) | 5 | MET A 231LEU A 234LEU A 237ALA A 238LEU A 170 | NoneNoneNoneNoneMYR A 315 ( 4.7A) | 1.07A | 3olsA-3ee4A:3.1 | 3olsA-3ee4A:21.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eno | PUTATIVEO-SIALOGLYCOPROTEINENDOPEPTIDASE (Thermoplasmaacidophilum) |
PF00814(Peptidase_M22) | 5 | LEU A 295LEU A 296ALA A 293GLU A 113GLY A 16 | None | 1.01A | 3olsA-3enoA:undetectable | 3olsA-3enoA:22.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3epm | THIAMINEBIOSYNTHESIS PROTEINTHIC (Caulobactervibrioides) |
PF01964(ThiC_Rad_SAM)PF13667(ThiC-associated) | 5 | ALA A 462LEU A 473LEU A 442GLY A 493HIS A 455 | None | 1.05A | 3olsA-3epmA:undetectable | 3olsA-3epmA:17.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3erv | PUTATIVE C39-LIKEPEPTIDASE (Bacillusanthracis) |
PF13529(Peptidase_C39_2) | 5 | LEU A 134LEU A 137ALA A 138MET A 80LEU A 81 | None | 1.12A | 3olsA-3ervA:undetectable | 3olsA-3ervA:23.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f7c | PROTEIN OF UNKNOWNFUNCTION (DUF416) (Marinobacterhydrocarbonoclasticus) |
PF04222(DUF416) | 5 | LEU A 22LEU A 23ALA A 20HIS A 113LEU A 13 | None | 1.01A | 3olsA-3f7cA:undetectable | 3olsA-3f7cA:21.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kba | PROGESTERONERECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 718LEU A 721MET A 756LEU A 763ARG A 766 | WOW A 1 (-4.2A)WOW A 1 ( 4.3A)WOW A 1 ( 4.1A)WOW A 1 ( 4.0A)WOW A 1 (-3.8A) | 0.38A | 3olsA-3kbaA:27.9 | 3olsA-3kbaA:30.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn1 | GOLGI PHOSPHOPROTEIN3 (Homo sapiens) |
PF05719(GPP34) | 6 | LEU A 133ALA A 136GLU A 135ARG A 176GLY A 91LEU A 94 | None | 1.35A | 3olsA-3kn1A:undetectable | 3olsA-3kn1A:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kn1 | GOLGI PHOSPHOPROTEIN3 (Homo sapiens) |
PF05719(GPP34) | 6 | LEU A 133ALA A 136GLU A 135LEU A 170GLY A 91LEU A 94 | None | 1.25A | 3olsA-3kn1A:undetectable | 3olsA-3kn1A:23.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qrx | CENTRINMELITTIN (Apis mellifera;Chlamydomonasreinhardtii) |
PF01372(Melittin)PF13499(EF-hand_7) | 5 | LEU B 13LEU B 16LEU A 134LEU A 123GLY A 131 | None | 1.08A | 3olsA-3qrxB:undetectable | 3olsA-3qrxB:8.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rde | ARACHIDONATE12-LIPOXYGENASE,12S-TYPE (Sus scrofa) |
PF00305(Lipoxygenase) | 5 | LEU A 358ALA A 433LEU A 281LEU A 282HIS A 356 | None | 1.12A | 3olsA-3rdeA:undetectable | 3olsA-3rdeA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ry9 | ANCESTRALGLUCOCORTICOIDRECEPTOR 1 (syntheticconstruct) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1CA A 249 (-3.9A)1CA A 249 ( 4.4A)1CA A 249 ( 3.8A)1CA A 249 ( 4.1A)1CA A 249 (-3.5A) | 0.27A | 3olsA-3ry9A:28.6 | 3olsA-3ry9A:29.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3u07 | UNCHARACTERIZEDPROTEIN VPA0106 (Vibrioparahaemolyticus) |
PF06742(DUF1214)PF06863(DUF1254) | 5 | MET A 267LEU A 270LEU A 273ALA A 274LEU A 304 | None | 0.78A | 3olsA-3u07A:undetectable | 3olsA-3u07A:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ubo | ADENOSINE KINASE (Sinorhizobiummeliloti) |
PF00294(PfkB) | 5 | LEU A 300LEU A 303ALA A 304LEU A 320GLY A 73 | None | 0.87A | 3olsA-3uboA:undetectable | 3olsA-3uboA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3un6 | HYPOTHETICAL PROTEINSAOUHSC_00137 (Staphylococcusaureus) |
PF13379(NMT1_2) | 5 | LEU A 93LEU A 96ALA A 97LEU A 78HIS A 114 | NoneNoneNoneNone ZN A 325 ( 4.9A) | 1.10A | 3olsA-3un6A:undetectable | 3olsA-3un6A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3v7n | THREONINE SYNTHASE (Burkholderiathailandensis) |
PF00291(PALP)PF14821(Thr_synth_N) | 5 | LEU A 123ALA A 430GLU A 428ARG A 91GLY A 436 | None | 1.03A | 3olsA-3v7nA:undetectable | 3olsA-3v7nA:18.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aur | LEOA (Escherichiacoli) |
PF00350(Dynamin_N) | 5 | LEU A 288ALA A 289LEU A 418GLY A 32LEU A 28 | None | 1.03A | 3olsA-4aurA:undetectable | 3olsA-4aurA:15.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bf7 | ARABINOGALACTANENDO-1,4-BETA-GALACTOSIDASE A (Aspergillusnidulans) |
PF07745(Glyco_hydro_53) | 5 | LEU A 278LEU A 281ALA A 282LEU A 2GLY A 331 | NoneNone ZN A 413 ( 4.7A)NoneNone | 0.84A | 3olsA-4bf7A:undetectable | 3olsA-4bf7A:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | LEU A 816LEU A 819GLU A 823GLY A 991LEU A 987 | None | 1.13A | 3olsA-4bfrA:undetectable | 3olsA-4bfrA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bfr | PHOSPHATIDYLINOSITOL4,5-BISPHOSPHATE3-KINASE CATALYTIC SSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd) | 5 | MET A 813LEU A 816LEU A 819GLU A 823GLY A 991 | None | 0.93A | 3olsA-4bfrA:undetectable | 3olsA-4bfrA:13.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cad | RAS AND A-FACTORCONVERTING ENZYME 1,RCE1 (Methanococcusmaripaludis) |
PF02517(Abi) | 5 | LEU C 132LEU C 135ALA C 136LEU C 48LEU C 45 | None | 0.84A | 3olsA-4cadC:undetectable | 3olsA-4cadC:24.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3a | SUGAR KINASE PROTEIN (Rhizobium etli) |
PF00294(PfkB) | 5 | LEU A 298LEU A 301ALA A 302LEU A 318GLY A 71 | None | 0.85A | 3olsA-4e3aA:undetectable | 3olsA-4e3aA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4exb | PUTATIVEUNCHARACTERIZEDPROTEIN (Pseudomonasaeruginosa) |
PF00248(Aldo_ket_red) | 5 | MET A 186LEU A 211ALA A 246LEU A 23GLY A 26 | None | 0.96A | 3olsA-4exbA:undetectable | 3olsA-4exbA:22.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f6t | MOLYBDENUM STORAGEPROTEIN SUBUNIT BETA (Azotobactervinelandii) |
PF00696(AA_kinase) | 5 | LEU B 131ALA B 129LEU B 176GLY B 181LEU B 35 | None8M0 B 302 (-3.1A)8M0 B 302 (-4.2A)NoneNone | 1.06A | 3olsA-4f6tB:undetectable | 3olsA-4f6tB:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i93 | PROBABLESERINE/THREONINE-PROTEIN KINASEAT5G41260 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | ALA A 104LEU A 118LEU A 110GLY A 201HIS A 180 | None | 0.89A | 3olsA-4i93A:undetectable | 3olsA-4i93A:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iss | ALLOPHANATEHYDROLASE (Kluyveromyceslactis) |
PF01425(Amidase) | 5 | LEU A 187LEU A 217ALA A 216LEU A 168GLY A 171 | None | 0.99A | 3olsA-4issA:undetectable | 3olsA-4issA:16.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4iuw | NEUTRALENDOPEPTIDASE (Lactobacillusrhamnosus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | LEU A 286LEU A 289ALA A 290LEU A 276LEU A 275 | None | 1.12A | 3olsA-4iuwA:undetectable | 3olsA-4iuwA:17.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jr7 | CASEIN KINASE IISUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | ALA A 357GLU A 356LEU A 352ARG A 10GLY A 258 | None | 1.09A | 3olsA-4jr7A:undetectable | 3olsA-4jr7A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lu1 | MAF-LIKE PROTEINYCEF (Escherichiacoli) |
PF02545(Maf) | 5 | LEU A 108ALA A 53GLY A 114HIS A 115LEU A 116 | None | 0.80A | 3olsA-4lu1A:undetectable | 3olsA-4lu1A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4md8 | CASEIN KINASE IISUBUNIT ALPHA (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA E 318GLU E 317LEU E 313ARG E 10GLY E 219 | None | 1.06A | 3olsA-4md8E:undetectable | 3olsA-4md8E:20.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 8 | LEU A 283LEU A 286ALA A 287GLU A 290MET A 321LEU A 324ARG A 331GLY A 447 | None | 0.44A | 3olsA-4n1yA:31.7 | 3olsA-4n1yA:38.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4n1y | ESTROGEN RECEPTOR (Crassostreagigas) |
PF00104(Hormone_recep) | 6 | LEU A 286ALA A 287GLU A 290LEU A 324ARG A 331GLY A 444 | None | 1.17A | 3olsA-4n1yA:31.7 | 3olsA-4n1yA:38.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nee | AP-2 COMPLEX SUBUNITALPHA-2 (Rattusnorvegicus) |
no annotation | 5 | MET G 353ALA G 389LEU G 377HIS G 369LEU G 338 | None | 1.07A | 3olsA-4neeG:undetectable | 3olsA-4neeG:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nte | DEPH (Chromobacteriumviolaceum) |
PF07992(Pyr_redox_2) | 5 | MET A 256LEU A 109ALA A 110LEU A 229GLY A 273 | NoneNoneNoneNone NA A 302 (-3.5A) | 1.07A | 3olsA-4nteA:undetectable | 3olsA-4nteA:20.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p6w | GLUCOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | LEU A 563LEU A 566MET A 601LEU A 608ARG A 611 | MOF A 801 (-3.9A)MOF A 801 ( 4.6A)MOF A 801 (-3.7A)MOF A 801 ( 4.6A)MOF A 801 (-4.2A) | 0.68A | 3olsA-4p6wA:28.3 | 3olsA-4p6wA:29.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qxl | FLAGELLAR PROTEINFLHE (Salmonellaenterica) |
PF06366(FlhE) | 5 | LEU A 15LEU A 98ALA A 101LEU A 54GLY A 12 | None | 1.11A | 3olsA-4qxlA:undetectable | 3olsA-4qxlA:19.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4rly | NAV1.2 - ANKBCHIMERA (Homo sapiens;Mus musculus) |
PF00023(Ank)PF12796(Ank_2)PF13637(Ank_4) | 5 | LEU A2210LEU A2211ALA A2208LEU A2167GLY A2163 | None | 1.07A | 3olsA-4rlyA:undetectable | 3olsA-4rlyA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4s15 | NUCLEAR RECEPTORROR-ALPHA (Homo sapiens) |
PF00104(Hormone_recep) | 5 | MET A 270LEU A 273LEU A 276ALA A 277LEU A 422 | None | 0.63A | 3olsA-4s15A:22.9 | 3olsA-4s15A:22.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tx2 | NON-RIBOSOMALPEPTIDE SYNTHETASE (Actinoplanesteichomyceticus) |
PF00668(Condensation) | 5 | LEU B 270LEU B 267ALA B 266LEU B 441LEU B 455 | None | 1.11A | 3olsA-4tx2B:undetectable | 3olsA-4tx2B:19.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u98 | MALTOKINASE (Mycolicibacteriumvanbaalenii) |
PF01636(APH) | 5 | LEU A 406ALA A 407GLU A 410HIS A 449LEU A 447 | None | 1.08A | 3olsA-4u98A:undetectable | 3olsA-4u98A:17.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4udb | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
PF00104(Hormone_recep) | 7 | LEU A 769LEU A 772ALA A 773MET A 807LEU A 810LEU A 814ARG A 817 | CV7 A1987 (-4.1A)CV7 A1987 ( 4.5A)CV7 A1987 (-3.5A)CV7 A1987 ( 3.9A)CV7 A1987 (-4.0A)CV7 A1987 ( 4.0A)CV7 A1987 (-3.7A) | 0.47A | 3olsA-4udbA:28.1 | 3olsA-4udbA:27.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xb6 | ALPHA-D-RIBOSE1-METHYLPHOSPHONATE5-TRIPHOSPHATESYNTHASE SUBUNITPHNI (Escherichiacoli) |
PF05861(PhnI) | 5 | LEU C 204LEU C 207ALA C 208LEU C 294GLY C 274 | None | 0.87A | 3olsA-4xb6C:undetectable | 3olsA-4xb6C:20.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ybq | SOLUTE CARRIERFAMILY 2,FACILITATED GLUCOSETRANSPORTER MEMBER 5 (Rattusnorvegicus) |
PF00083(Sugar_tr) | 5 | LEU A 233ALA A 232LEU A 219LEU A 220LEU A 152 | None | 1.09A | 3olsA-4ybqA:undetectable | 3olsA-4ybqA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yub | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Homo sapiens) |
no annotation | 5 | LEU A 56LEU A 114ALA A 115LEU A 109GLY A 59 | None | 1.07A | 3olsA-4yubA:undetectable | 3olsA-4yubA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zk6 | QUINOLINATE SYNTHASEA (Pyrococcushorikoshii) |
PF02445(NadA) | 5 | MET A 61LEU A 68ALA A 45GLY A 36HIS A 21 | NTM A 402 (-3.5A)NoneNoneNoneNTM A 402 ( 3.9A) | 1.09A | 3olsA-4zk6A:undetectable | 3olsA-4zk6A:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zmu | DIGUANYLATE CYCLASE (Pseudomonasaeruginosa) |
PF00990(GGDEF)PF01590(GAF) | 5 | MET A 20LEU A 17GLU A 10ARG A 72GLY A 123 | None | 1.11A | 3olsA-4zmuA:undetectable | 3olsA-4zmuA:19.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5b3k | UNCHARACTERIZEDPROTEIN PA3435 (Pseudomonasaeruginosa) |
PF00258(Flavodoxin_1) | 5 | LEU A 6LEU A 67LEU A 110GLY A 86LEU A 52 | None | 1.12A | 3olsA-5b3kA:undetectable | 3olsA-5b3kA:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5by6 | THYMIDYLATE SYNTHASE (Trichinellaspiralis) |
PF00303(Thymidylat_synt) | 5 | LEU A 30LEU A 27GLU A 23LEU A 68GLY A 216 | NoneNoneNoneNoneUMP A 401 (-3.5A) | 1.11A | 3olsA-5by6A:undetectable | 3olsA-5by6A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cde | PROLINE DIPEPTIDASE (Xanthomonascampestris) |
PF00557(Peptidase_M24)PF01321(Creatinase_N) | 5 | LEU A 76ALA A 75LEU A 52LEU A 51GLY A 136 | None | 1.13A | 3olsA-5cdeA:undetectable | 3olsA-5cdeA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e7p | CELL DIVISIONCONTROL PROTEINCDC48 (Mycolicibacteriumsmegmatis) |
PF00004(AAA)PF02359(CDC48_N) | 5 | LEU A 24LEU A 60LEU A 101GLY A 93LEU A 89 | None | 1.09A | 3olsA-5e7pA:undetectable | 3olsA-5e7pA:14.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5et1 | ESPIN (Mus musculus) |
PF12796(Ank_2)PF13637(Ank_4)PF13857(Ank_5) | 5 | LEU A 89LEU A 90LEU A 83GLY A 47LEU A 49 | None | 1.02A | 3olsA-5et1A:undetectable | 3olsA-5et1A:21.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ex6 | CYTOCHROME P450 (Streptomycestoyocaensis) |
no annotation | 5 | MET C 244LEU C 247LEU C 250ALA C 251LEU C 276 | None | 0.98A | 3olsA-5ex6C:undetectable | 3olsA-5ex6C:21.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gk9 | BRD1 PROTEINHISTONEACETYLTRANSFERASEKAT7 (Homo sapiens) |
PF01853(MOZ_SAS)no annotation | 5 | MET A 564LEU A 575LEU A 573GLU B 58LEU A 531 | None | 1.08A | 3olsA-5gk9A:undetectable | 3olsA-5gk9A:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gnd | PUTATIVE SERINEPROTEASE HHOA (Synechocystissp. PCC 6803) |
PF13180(PDZ_2)PF13365(Trypsin_2) | 5 | LEU A 371LEU A 382ALA A 334ARG A 375GLY A 290 | None | 1.08A | 3olsA-5gndA:undetectable | 3olsA-5gndA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i8i | UREA AMIDOLYASE (Kluyveromyceslactis) |
PF00289(Biotin_carb_N)PF01425(Amidase)PF02626(CT_A_B)PF02682(CT_C_D)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | LEU A 187LEU A 217ALA A 216LEU A 168GLY A 171 | None | 1.00A | 3olsA-5i8iA:undetectable | 3olsA-5i8iA:8.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ijb | TOLL-LIKE RECEPTOR4, VARIABLELYMPHOCYTE RECEPTORB CHIMERA (Eptatretusburgeri;Mus musculus) |
PF00560(LRR_1)PF11921(DUF3439)PF13855(LRR_8) | 5 | LEU A 207LEU A 194LEU A 197GLY A 251LEU A 249 | None | 1.01A | 3olsA-5ijbA:undetectable | 3olsA-5ijbA:17.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j6s | ENDOPLASMICRETICULUMAMINOPEPTIDASE 2 (Homo sapiens) |
PF01433(Peptidase_M1)PF11838(ERAP1_C) | 5 | LEU A 757LEU A 754ALA A 753LEU A 697HIS A 708 | None | 1.00A | 3olsA-5j6sA:undetectable | 3olsA-5j6sA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kdx | METALLOPEPTIDASE (Pseudomonasaeruginosa) |
PF13402(Peptidase_M60) | 5 | LEU A 130LEU A 128LEU A 165GLY A 243LEU A 240 | None | 0.93A | 3olsA-5kdxA:undetectable | 3olsA-5kdxA:13.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mrw | POTASSIUM-TRANSPORTING ATPASEPOTASSIUM-BINDINGSUBUNIT (Escherichiacoli) |
PF03814(KdpA) | 5 | LEU A 422ALA A 420LEU A 385LEU A 389GLY A 369 | None | 0.94A | 3olsA-5mrwA:undetectable | 3olsA-5mrwA:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mwp | MINERALOCORTICOIDRECEPTOR (Homo sapiens) |
no annotation | 6 | LEU A 769LEU A 772ALA A 773MET A 807LEU A 814ARG A 817 | ECV A1101 (-4.7A)ECV A1101 ( 3.9A)ECV A1101 (-3.8A)ECV A1101 (-3.6A)ECV A1101 (-4.1A)ECV A1101 (-4.0A) | 0.33A | 3olsA-5mwpA:28.2 | 3olsA-5mwpA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tcb | PELA (Pseudomonasaeruginosa) |
PF03537(Glyco_hydro_114) | 5 | LEU A 142LEU A 143ALA A 140GLY A 117LEU A 114 | None | 0.84A | 3olsA-5tcbA:undetectable | 3olsA-5tcbA:18.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | LEU A 298LEU A 301GLU A 305MET A 340GLY A 472HIS A 475 | EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.8A)EST A 601 (-4.0A)EST A 601 (-4.4A) | 1.45A | 3olsA-5toaA:33.7 | 3olsA-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 294LEU A 298LEU A 301GLU A 305LEU A 343ARG A 346 | NoneEST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 (-2.4A)EST A 601 ( 4.4A)EST A 601 (-4.1A) | 1.43A | 3olsA-5toaA:33.7 | 3olsA-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 12 | MET A 295LEU A 298LEU A 301ALA A 302GLU A 305MET A 336LEU A 339LEU A 343ARG A 346GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 ( 4.3A)EST A 601 ( 3.9A)EST A 601 (-2.4A)EST A 601 ( 3.7A)EST A 601 (-3.9A)EST A 601 ( 4.4A)EST A 601 (-4.1A)EST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 0.39A | 3olsA-5toaA:33.7 | 3olsA-5toaA:99.58 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5toa | ESTROGEN RECEPTORBETA (Homo sapiens) |
PF00104(Hormone_recep) | 6 | MET A 295LEU A 298LEU A 354GLY A 472HIS A 475LEU A 476 | EST A 601 ( 4.4A)EST A 601 (-4.1A)NoneEST A 601 (-4.0A)EST A 601 (-4.4A)EST A 601 (-3.5A) | 1.33A | 3olsA-5toaA:33.7 | 3olsA-5toaA:99.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u4n | FRUCTOSE-1 (Neisseriagonorrhoeae) |
PF01116(F_bP_aldolase) | 5 | ALA A 193GLU A 142LEU A 146GLY A 152LEU A 149 | None | 1.05A | 3olsA-5u4nA:undetectable | 3olsA-5u4nA:20.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uc1 | GLUCOCORTICOIDRECEPTOR (Heterocephalusglaber) |
no annotation | 5 | LEU A 559LEU A 562MET A 597LEU A 604ARG A 607 | 486 A 801 (-4.7A)486 A 801 ( 4.8A)CPS A 803 ( 3.9A)486 A 801 ( 3.8A)486 A 801 (-3.5A) | 0.82A | 3olsA-5uc1A:23.1 | 3olsA-5uc1A:16.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ufs | ANCESTRALGLUCOCORTICOIDRECEPTOR2 (unidentified) |
PF00104(Hormone_recep) | 5 | LEU A 32LEU A 35MET A 70LEU A 77ARG A 80 | 1TA A 301 (-3.5A)1TA A 301 ( 3.6A)1TA A 301 ( 3.1A)1TA A 301 ( 3.4A)1TA A 301 (-3.5A) | 0.47A | 3olsA-5ufsA:29.2 | 3olsA-5ufsA:31.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c62 | BIURET HYDROLASE (Pseudomonas sp.ADP) |
no annotation | 5 | LEU A 221ALA A 222LEU A 165GLY A 186LEU A 187 | None | 1.10A | 3olsA-6c62A:undetectable | 3olsA-6c62A:14.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cza | - (-) |
no annotation | 5 | LEU A 395LEU A 392ALA A 391LEU A 335GLY A 326 | None | 1.06A | 3olsA-6czaA:undetectable | 3olsA-6czaA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6d04 | RETICULOCYTE BINDINGPROTEIN 2, PUTATIVE (Plasmodiumvivax) |
no annotation | 5 | LEU E 458LEU E 457GLY E 463HIS E 464LEU E 465 | None | 1.09A | 3olsA-6d04E:undetectable | 3olsA-6d04E:12.92 |