SIMILAR PATTERNS OF AMINO ACIDS FOR 3OLL_B_ESTB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
ARG A 394
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 ( 4.8A)
EST  A   1 (-2.8A)
None
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.38A 3ollB-1pcgA:
31.6		 3ollB-1pcgA:
59.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 324
LEU A 327
GLU A 331
MET A 362
ARG A 372
HIS A 494
 None
 0.64A 3ollB-1xb7A:
26.7		 3ollB-1xb7A:
34.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 268
LEU A 271
GLU A 275
MET A 306
ARG A 316
HIS A 434
 OHT  A 500 (-4.1A)
OHT  A 500 ( 4.4A)
OHT  A 500 (-2.6A)
OHT  A 500 (-3.9A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.58A 3ollB-2gpvA:
26.0		 3ollB-2gpvA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 346
LEU A 349
GLU A 353
MET A 388
HIS A 524
 EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
None
EST  A 596 (-4.2A)
 1.37A 3ollB-2ocfA:
32.8		 3ollB-2ocfA:
57.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
LEU A 346
LEU A 349
GLU A 353
MET A 388
ARG A 394
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 ( 4.1A)
EST  A 596 (-2.7A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.44A 3ollB-2ocfA:
32.8		 3ollB-2ocfA:
57.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8o TOXIN RNLA

(Escherichia
coli) 		PF15935
(RnlA_toxin) 		5 LEU A 117
LEU A 114
GLU A 110
ARG A 133
LEU A 179
 None
 1.42A 3ollB-4i8oA:
0.0		 3ollB-4i8oA:
21.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		5 LEU A 283
LEU A 286
GLU A 290
MET A 321
ARG A 331
 None
 0.49A 3ollB-4n1yA:
29.3		 3ollB-4n1yA:
38.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		9 MET A 295
LEU A 298
LEU A 301
GLU A 305
MET A 336
MET A 340
ARG A 346
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.3A)
EST  A 601 (-2.4A)
EST  A 601 ( 3.7A)
EST  A 601 ( 4.8A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.33A 3ollB-5toaA:
31.9		 3ollB-5toaA:
99.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tuc SUS TBC1D15 GAP
DOMAIN

(Sus scrofa) 		PF00566
(RabGAP-TBC) 		5 LEU A 488
LEU A 492
GLU A 554
ARG A 291
LEU A 508
 None
 1.40A 3ollB-5tucA:
0.0		 3ollB-5tucA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6axe MALATE SYNTHASE G

(Mycobacterium
marinum) 		PF01274
(Malate_synthase) 		5 MET A 270
LEU A 336
LEU A 335
GLU A 108
ARG A 393
 None
 1.26A 3ollB-6axeA:
0.0		 3ollB-6axeA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byi BETA-MANNOSIDASE

(Xanthomonas
citri) 		no annotation 5 LEU A 638
LEU A 641
GLU A 645
ARG A 830
LEU A 618
 None
 1.31A 3ollB-6byiA:
undetectable		 3ollB-6byiA:
undetectable