SIMILAR PATTERNS OF AMINO ACIDS FOR 3OKX_B_SAMB201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9g PROTEIN (GROWTH
FACTOR IGF-1)

(Homo sapiens) 		PF00049
(Insulin) 		3 LYS A  55
ARG A  43
LYS A  27
 None
 1.11A 3okxA-1b9gA:
undetectable		 3okxA-1b9gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 LYS L 370
ARG L 377
LYS L 328
 None
 1.38A 3okxA-1cc1L:
undetectable		 3okxA-1cc1L:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 LYS A 418
ARG A 187
LYS A 193
 None
 1.34A 3okxA-1dgsA:
0.0		 3okxA-1dgsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 422
ARG A 256
LYS A 328
 U  B  33 ( 4.4A)
A  B  36 ( 3.7A)
None
 1.12A 3okxA-1h3eA:
undetectable		 3okxA-1h3eA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io3 CYTOCHROME C2

(Blastochloris
viridis) 		PF00034
(Cytochrom_C) 		3 LYS A  73
ARG A  68
LYS A  98
 None
 1.43A 3okxA-1io3A:
undetectable		 3okxA-1io3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		3 LYS A 121
ARG A 117
LYS A  60
 None
 1.47A 3okxA-1j9aA:
undetectable		 3okxA-1j9aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 LYS A 187
ARG A 270
LYS A 244
 None
 1.30A 3okxA-1pyfA:
undetectable		 3okxA-1pyfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Homo sapiens) 		PF03166
(MH2) 		3 LYS B 314
ARG B 531
LYS B 436
 None
 1.37A 3okxA-1u7vB:
0.0		 3okxA-1u7vB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 LYS A 421
ARG A 192
LYS A 198
 None
 1.49A 3okxA-1v9pA:
0.0		 3okxA-1v9pA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 LYS A  26
ARG A  22
LYS A 312
 None
 1.36A 3okxA-1wpwA:
undetectable		 3okxA-1wpwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		3 LYS A 327
ARG A 272
LYS A 110
 None
 1.38A 3okxA-1x3wA:
0.0		 3okxA-1x3wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 LYS A 257
ARG A 232
LYS A  25
 None
 1.34A 3okxA-1xp4A:
undetectable		 3okxA-1xp4A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		3 LYS A  88
ARG A 283
LYS A 333
 None
C  G   7 ( 3.5A)
None
 1.20A 3okxA-1yvpA:
undetectable		 3okxA-1yvpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		3 LYS A 167
ARG A 290
LYS A 249
 None
 1.39A 3okxA-1z7mA:
undetectable		 3okxA-1z7mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		3 LYS A 249
ARG A 237
LYS A 153
 None
 1.05A 3okxA-1zchA:
undetectable		 3okxA-1zchA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ZTAQ AFFIBODY
ANTI-ZTAQ AFFIBODY

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF02216
(B)
PF02216
(B) 		3 LYS B   1
ARG B   9
LYS A  49
 None
 1.46A 3okxA-2b87B:
undetectable		 3okxA-2b87B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		3 LYS A 272
ARG A 467
LYS A 477
 None
 1.48A 3okxA-2bf6A:
undetectable		 3okxA-2bf6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		3 LYS A 357
ARG A 304
LYS A 291
 None
None
1PE  A1366 ( 2.4A)
 1.39A 3okxA-2bi3A:
undetectable		 3okxA-2bi3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		3 LYS A 165
ARG A 197
LYS A 267
 None
 1.16A 3okxA-2e28A:
2.6		 3okxA-2e28A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LYS A  86
ARG A  92
LYS A 267
 None
 0.99A 3okxA-2eq9A:
undetectable		 3okxA-2eq9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		3 LYS A 377
ARG A 120
LYS A 310
 None
 1.43A 3okxA-2frxA:
undetectable		 3okxA-2frxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		3 LYS A 140
ARG A 106
LYS A  65
 None
 1.43A 3okxA-2g29A:
undetectable		 3okxA-2g29A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9d CHLORAMPHENICOL
ACETYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00302
(CAT) 		3 LYS A   2
ARG A  76
LYS A 163
 None
 1.28A 3okxA-2i9dA:
undetectable		 3okxA-2i9dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 3 LYS A 138
ARG A 173
LYS A 207
 None
 1.43A 3okxA-2iouA:
undetectable		 3okxA-2iouA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 LYS A  81
ARG A 235
LYS A 135
 None
 1.21A 3okxA-2isnA:
undetectable		 3okxA-2isnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyn UPF0368 PROTEIN
YPL225W

(Saccharomyces
cerevisiae) 		PF04669
(Polysacc_synt_4) 		3 LYS A 135
ARG A  43
LYS A  95
 None
 1.46A 3okxA-2jynA:
undetectable		 3okxA-2jynA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 425
ARG A 384
LYS A 371
 None
 1.45A 3okxA-2oudA:
undetectable		 3okxA-2oudA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 LYS A 166
ARG A 151
LYS A 138
 None
P3T  A 501 (-3.9A)
None
 1.43A 3okxA-2pljA:
undetectable		 3okxA-2pljA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqx ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		3 LYS A 889
ARG A 923
LYS A 818
 None
 1.40A 3okxA-2xqxA:
undetectable		 3okxA-2xqxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		3 LYS A  96
ARG A  77
LYS A  34
 None
 1.07A 3okxA-2y4tA:
undetectable		 3okxA-2y4tA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LYS A 605
ARG A 413
LYS A 452
 None
None
EDO  A 837 (-2.6A)
 1.45A 3okxA-3ahiA:
undetectable		 3okxA-3ahiA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LYS A 605
ARG A 413
LYS A 452
 None
 1.42A 3okxA-3ai7A:
undetectable		 3okxA-3ai7A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 LYS A 505
ARG A 854
LYS A 715
 None
 1.22A 3okxA-3aibA:
undetectable		 3okxA-3aibA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		3 LYS A 122
ARG A 140
LYS A 110
 None
 1.42A 3okxA-3ax6A:
undetectable		 3okxA-3ax6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		3 LYS A1060
ARG A1054
LYS A 994
 None
 1.49A 3okxA-3bsxA:
undetectable		 3okxA-3bsxA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		3 LYS A 159
ARG A 121
LYS A  52
 None
 1.35A 3okxA-3d43A:
undetectable		 3okxA-3d43A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 LYS A  15
ARG A  48
LYS A 210
 None
 1.46A 3okxA-3eqqA:
undetectable		 3okxA-3eqqA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		3 LYS A 222
ARG A 340
LYS A  17
 SO4  A 361 (-3.5A)
SO4  A 363 (-3.2A)
None
 1.36A 3okxA-3ffhA:
undetectable		 3okxA-3ffhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 750
ARG A 538
LYS A 600
 None
 1.33A 3okxA-3h0gA:
undetectable		 3okxA-3h0gA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 LYS A 230
ARG A 226
LYS A 276
 None
 1.20A 3okxA-3kh8A:
undetectable		 3okxA-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		3 LYS A  99
ARG A  90
LYS A  79
 None
 1.33A 3okxA-3mn1A:
undetectable		 3okxA-3mn1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 LYS A  62
ARG A  85
LYS A 370
 None
 1.37A 3okxA-3mn8A:
undetectable		 3okxA-3mn8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 LYS A 179
ARG A 208
LYS A  48
 None
 1.41A 3okxA-3oetA:
undetectable		 3okxA-3oetA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		3 LYS A 143
ARG A 146
LYS A 156
 None
 0.02A 3okxA-3okxA:
27.3		 3okxA-3okxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 LYS A 984
ARG A1337
LYS A 975
 None
 1.14A 3okxA-3ptaA:
undetectable		 3okxA-3ptaA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		3 LYS A 288
ARG A 255
LYS A 302
 None
 1.31A 3okxA-3pzlA:
undetectable		 3okxA-3pzlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb5 TRANSLIN-ASSOCIATED
PROTEIN X

(Homo sapiens) 		PF01997
(Translin) 		3 LYS K  68
ARG K 200
LYS K 241
 SO4  K 294 ( 2.6A)
SO4  K 293 (-3.4A)
None
 1.36A 3okxA-3qb5K:
undetectable		 3okxA-3qb5K:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LYS A 326
ARG A 463
LYS A  11
 None
 1.15A 3okxA-3qr1A:
undetectable		 3okxA-3qr1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 LYS A 376
ARG A 369
LYS A 472
 None
 1.31A 3okxA-3snhA:
undetectable		 3okxA-3snhA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlp THIOREDOXIN
PEROXIDASE

(Schistosoma
mansoni) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 LYS A 143
ARG A 147
LYS A   3
 None
 1.42A 3okxA-3zlpA:
undetectable		 3okxA-3zlpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 LYS A   1
ARG A  24
LYS A 118
 None
 1.17A 3okxA-4c7gA:
undetectable		 3okxA-4c7gA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		3 LYS A 201
ARG A 172
LYS A  91
 None
 1.48A 3okxA-4d51A:
undetectable		 3okxA-4d51A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  62
ARG A  36
LYS A 123
 None
 1.34A 3okxA-4es7A:
undetectable		 3okxA-4es7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 LYS X 496
ARG X 498
LYS X 540
 None
 1.37A 3okxA-4hscX:
undetectable		 3okxA-4hscX:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 LYS C   6
ARG C 106
LYS C  41
 None
 1.35A 3okxA-4iypC:
undetectable		 3okxA-4iypC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 LYS A 125
ARG A 103
LYS A 320
 None
 1.13A 3okxA-4lejA:
undetectable		 3okxA-4lejA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 LYS A  15
ARG A  59
LYS A 307
 None
 1.44A 3okxA-4ns4A:
undetectable		 3okxA-4ns4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A  56
ARG A  48
LYS A 181
 None
 1.47A 3okxA-4o8cA:
undetectable		 3okxA-4o8cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		3 LYS A 161
ARG A 168
LYS A  99
 None
 1.09A 3okxA-4p3zA:
undetectable		 3okxA-4p3zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 LYS A 301
ARG A  23
LYS A   9
 ZN  A 409 ( 4.6A)
None
None
 1.47A 3okxA-4pueA:
undetectable		 3okxA-4pueA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A 370
ARG A 368
LYS A 476
 None
 1.34A 3okxA-4rvwA:
undetectable		 3okxA-4rvwA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 3 LYS A1991
ARG A1662
LYS A1871
 SO4  A2409 (-3.1A)
SO4  A2409 (-3.1A)
None
 1.33A 3okxA-4uclA:
undetectable		 3okxA-4uclA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 LYS A 165
ARG A 195
LYS A 207
 None
 1.45A 3okxA-4uj6A:
undetectable		 3okxA-4uj6A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8k CAS1 PROTEIN

(Vibrio phage
ICP1) 		PF01867
(Cas_Cas1) 		3 LYS A 151
ARG A 144
LYS A 189
 None
 1.37A 3okxA-4w8kA:
undetectable		 3okxA-4w8kA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		3 LYS A  77
ARG A 109
LYS A 143
 None
 1.50A 3okxA-4xjvA:
undetectable		 3okxA-4xjvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 LYS G 810
ARG G 859
LYS L 550
 None
 1.03A 3okxA-4xr7G:
undetectable		 3okxA-4xr7G:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anr PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS B 413
ARG B 421
LYS B 367
 None
 1.15A 3okxA-5anrB:
undetectable		 3okxA-5anrB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 LYS A  35
ARG A   9
LYS A  49
 None
 1.48A 3okxA-5cwnA:
undetectable		 3okxA-5cwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		3 LYS A 100
ARG A 132
LYS A  47
 None
None
PLP  A1001 (-1.3A)
 1.26A 3okxA-5d86A:
undetectable		 3okxA-5d86A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		3 LYS A 150
ARG A 230
LYS A 220
 None
HEM  A 401 (-2.6A)
None
 1.28A 3okxA-5de0A:
undetectable		 3okxA-5de0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 LYS A 312
ARG A 161
LYS A 385
 None
 1.50A 3okxA-5dn6A:
3.0		 3okxA-5dn6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 LYS A  13
ARG A  18
LYS A  29
 None
 1.40A 3okxA-5eytA:
undetectable		 3okxA-5eytA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		3 LYS A 160
ARG A 122
LYS A  53
 None
 1.39A 3okxA-5ffnA:
undetectable		 3okxA-5ffnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo TRANSFORMING GROWTH
FACTOR BETA-1

(Homo sapiens) 		PF00019
(TGF_beta)
PF00688
(TGFb_propeptide) 		3 LYS C  77
ARG C  29
LYS C 319
 None
 1.22A 3okxA-5ffoC:
undetectable		 3okxA-5ffoC:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 LYS L 306
ARG L 334
LYS H 345
 None
 0.84A 3okxA-5fhxL:
undetectable		 3okxA-5fhxL:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LYS d 198
ARG d 195
LYS d 290
 None
 1.30A 3okxA-5gw5d:
undetectable		 3okxA-5gw5d:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 LYS A1644
ARG A1673
LYS A1534
 None
 1.42A 3okxA-5i6hA:
undetectable		 3okxA-5i6hA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 LYS A 303
ARG A 161
LYS A 376
 None
 1.48A 3okxA-5ik2A:
3.1		 3okxA-5ik2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9

(Homo sapiens;
Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01096
(TFIIS_C)
PF02150
(RNA_POL_M_15KD) 		3 LYS A1306
ARG A1224
LYS I  57
 None
 1.45A 3okxA-5iy9A:
undetectable		 3okxA-5iy9A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 369
ARG A 333
LYS A 233
 None
 1.46A 3okxA-5ko1A:
1.6		 3okxA-5ko1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 3 LYS A  16
ARG A  20
LYS A 278
 None
 1.32A 3okxA-5nxnA:
undetectable		 3okxA-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L35,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF01632
(Ribosomal_L35p)
PF01161
(PBP) 		3 LYS 6 355
ARG 6 368
LYS 3 126
 None
G  A2860 ( 2.9A)
A  A2869 ( 3.4A)
 1.40A 3okxA-5ool6:
undetectable		 3okxA-5ool6:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 3 LYS A 198
ARG A 320
LYS A 412
 None
 1.36A 3okxA-5x09A:
undetectable		 3okxA-5x09A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0i KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		no annotation 3 LYS K 306
ARG K 330
LYS K 580
 None
 1.27A 3okxA-6b0iK:
undetectable		 3okxA-6b0iK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 3 LYS A 338
ARG A  40
LYS A 261
 U  E   3 (-2.6A)
A  E   2 (-3.3A)
A  E   4 ( 3.0A)
 1.38A 3okxA-6c6kA:
undetectable		 3okxA-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 LYS A 463
ARG A 460
LYS A 291
 EDO  A 612 (-3.4A)
EDO  A 612 (-3.3A)
None
 1.07A 3okxA-6cc2A:
undetectable		 3okxA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 3 LYS A 132
ARG A  74
LYS A  -2
 None
 1.27A 3okxA-6dinA:
undetectable		 3okxA-6dinA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 LYS A 493
ARG A 134
LYS A  68
 None
 1.46A 3okxA-6em0A:
undetectable		 3okxA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 595
ARG A 608
LYS A 522
 None
 0.92A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1512
ARG A1507
LYS A1470
 None
 1.44A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1643
ARG A1678
LYS A1656
 None
 1.30A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 LYS C 304
ARG C 162
LYS C 377
 None
 1.47A 3okxA-6fkhC:
2.6		 3okxA-6fkhC:
undetectable