SIMILAR PATTERNS OF AMINO ACIDS FOR 3OKX_B_SAMB201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9g PROTEIN (GROWTH
FACTOR IGF-1)

(Homo sapiens) 		PF00049
(Insulin) 		3 LYS A  55
ARG A  43
LYS A  27
 None
 1.11A 3okxA-1b9gA:
undetectable		 3okxA-1b9gA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cc1 HYDROGENASE (LARGE
SUBUNIT)

(Desulfomicrobium
baculatum) 		PF00374
(NiFeSe_Hases) 		3 LYS L 370
ARG L 377
LYS L 328
 None
 1.38A 3okxA-1cc1L:
undetectable		 3okxA-1cc1L:
17.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 LYS A 418
ARG A 187
LYS A 193
 None
 1.34A 3okxA-1dgsA:
0.0		 3okxA-1dgsA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3e TYROSYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00579
(tRNA-synt_1b) 		3 LYS A 422
ARG A 256
LYS A 328
 U  B  33 ( 4.4A)
A  B  36 ( 3.7A)
None
 1.12A 3okxA-1h3eA:
undetectable		 3okxA-1h3eA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1io3 CYTOCHROME C2

(Blastochloris
viridis) 		PF00034
(Cytochrom_C) 		3 LYS A  73
ARG A  68
LYS A  98
 None
 1.43A 3okxA-1io3A:
undetectable		 3okxA-1io3A:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j9a OLIGORIBONUCLEASE

(Haemophilus
influenzae) 		PF00929
(RNase_T) 		3 LYS A 121
ARG A 117
LYS A  60
 None
 1.47A 3okxA-1j9aA:
undetectable		 3okxA-1j9aA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		3 LYS A 187
ARG A 270
LYS A 244
 None
 1.30A 3okxA-1pyfA:
undetectable		 3okxA-1pyfA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7v MOTHERS AGAINST
DECAPENTAPLEGIC
HOMOLOG 4

(Homo sapiens) 		PF03166
(MH2) 		3 LYS B 314
ARG B 531
LYS B 436
 None
 1.37A 3okxA-1u7vB:
0.0		 3okxA-1u7vB:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		3 LYS A 421
ARG A 192
LYS A 198
 None
 1.49A 3okxA-1v9pA:
0.0		 3okxA-1v9pA:
15.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wpw 3-ISOPROPYLMALATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 LYS A  26
ARG A  22
LYS A 312
 None
 1.36A 3okxA-1wpwA:
undetectable		 3okxA-1wpwA:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3w PEPTIDE:N-GLYCANASE

(Saccharomyces
cerevisiae) 		PF03835
(Rad4) 		3 LYS A 327
ARG A 272
LYS A 110
 None
 1.38A 3okxA-1x3wA:
0.0		 3okxA-1x3wA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xp4 D-ALANYL-D-ALANINE
CARBOXYPEPTIDASE

(Streptococcus
pneumoniae) 		PF00768
(Peptidase_S11)
PF07943
(PBP5_C) 		3 LYS A 257
ARG A 232
LYS A  25
 None
 1.34A 3okxA-1xp4A:
undetectable		 3okxA-1xp4A:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yvp 60-KDA SS-A/RO
RIBONUCLEOPROTEIN

(Xenopus laevis) 		PF05731
(TROVE) 		3 LYS A  88
ARG A 283
LYS A 333
 None
C  G   7 ( 3.5A)
None
 1.20A 3okxA-1yvpA:
undetectable		 3okxA-1yvpA:
15.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z7m ATP
PHOSPHORIBOSYLTRANSF
ERASE REGULATORY
SUBUNIT

(Lactococcus
lactis) 		PF13393
(tRNA-synt_His) 		3 LYS A 167
ARG A 290
LYS A 249
 None
 1.39A 3okxA-1z7mA:
undetectable		 3okxA-1z7mA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zch HYPOTHETICAL
OXIDOREDUCTASE YCND

(Bacillus
subtilis) 		PF00881
(Nitroreductase) 		3 LYS A 249
ARG A 237
LYS A 153
 None
 1.05A 3okxA-1zchA:
undetectable		 3okxA-1zchA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b87 ZTAQ AFFIBODY
ANTI-ZTAQ AFFIBODY

(Staphylococcus
aureus;
Staphylococcus
aureus) 		PF02216
(B)
PF02216
(B) 		3 LYS B   1
ARG B   9
LYS A  49
 None
 1.46A 3okxA-2b87B:
undetectable		 3okxA-2b87B:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		3 LYS A 272
ARG A 467
LYS A 477
 None
 1.48A 3okxA-2bf6A:
undetectable		 3okxA-2bf6A:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bi3 PHOSPHOSERINE
AMINOTRANSFERASE

(Bacillus
alcalophilus) 		PF00266
(Aminotran_5) 		3 LYS A 357
ARG A 304
LYS A 291
 None
None
1PE  A1366 ( 2.4A)
 1.39A 3okxA-2bi3A:
undetectable		 3okxA-2bi3A:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e28 PYRUVATE KINASE

(Geobacillus
stearothermophilus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		3 LYS A 165
ARG A 197
LYS A 267
 None
 1.16A 3okxA-2e28A:
2.6		 3okxA-2e28A:
15.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 LYS A  86
ARG A  92
LYS A 267
 None
 0.99A 3okxA-2eq9A:
undetectable		 3okxA-2eq9A:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frx HYPOTHETICAL PROTEIN
YEBU

(Escherichia
coli) 		PF01189
(Methyltr_RsmB-F)
PF13636
(Methyltranf_PUA)
PF17125
(Methyltr_RsmF_N) 		3 LYS A 377
ARG A 120
LYS A 310
 None
 1.43A 3okxA-2frxA:
undetectable		 3okxA-2frxA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g29 NITRATE TRANSPORT
PROTEIN NRTA

(Synechocystis
sp.) 		PF13379
(NMT1_2) 		3 LYS A 140
ARG A 106
LYS A  65
 None
 1.43A 3okxA-2g29A:
undetectable		 3okxA-2g29A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9d CHLORAMPHENICOL
ACETYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00302
(CAT) 		3 LYS A   2
ARG A  76
LYS A 163
 None
 1.28A 3okxA-2i9dA:
undetectable		 3okxA-2i9dA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 3 LYS A 138
ARG A 173
LYS A 207
 None
 1.43A 3okxA-2iouA:
undetectable		 3okxA-2iouA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		3 LYS A  81
ARG A 235
LYS A 135
 None
 1.21A 3okxA-2isnA:
undetectable		 3okxA-2isnA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jyn UPF0368 PROTEIN
YPL225W

(Saccharomyces
cerevisiae) 		PF04669
(Polysacc_synt_4) 		3 LYS A 135
ARG A  43
LYS A  95
 None
 1.46A 3okxA-2jynA:
undetectable		 3okxA-2jynA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oud DUAL SPECIFICITY
PROTEIN PHOSPHATASE
10

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 425
ARG A 384
LYS A 371
 None
 1.45A 3okxA-2oudA:
undetectable		 3okxA-2oudA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2plj LYSINE/ORNITHINE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		3 LYS A 166
ARG A 151
LYS A 138
 None
P3T  A 501 (-3.9A)
None
 1.43A 3okxA-2pljA:
undetectable		 3okxA-2pljA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xqx ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE D

(Streptococcus
pneumoniae) 		PF00754
(F5_F8_type_C) 		3 LYS A 889
ARG A 923
LYS A 818
 None
 1.40A 3okxA-2xqxA:
undetectable		 3okxA-2xqxA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4t DNAJ HOMOLOG
SUBFAMILY C MEMBER 3

(Homo sapiens) 		PF00226
(DnaJ)
PF09976
(TPR_21)
PF13181
(TPR_8) 		3 LYS A  96
ARG A  77
LYS A  34
 None
 1.07A 3okxA-2y4tA:
undetectable		 3okxA-2y4tA:
16.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahi XYLULOSE
5-PHOSPHATE/FRUCTOSE
6-PHOSPHATE
PHOSPHOKETOLASE

(Bifidobacterium
breve) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LYS A 605
ARG A 413
LYS A 452
 None
None
EDO  A 837 (-2.6A)
 1.45A 3okxA-3ahiA:
undetectable		 3okxA-3ahiA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai7 XYLULOSE-5-PHOSPHATE
/FRUCTOSE-6-PHOSPHAT
E PHOSPHOKETOLASE

(Bifidobacterium
longum) 		PF03894
(XFP)
PF09363
(XFP_C)
PF09364
(XFP_N) 		3 LYS A 605
ARG A 413
LYS A 452
 None
 1.42A 3okxA-3ai7A:
undetectable		 3okxA-3ai7A:
12.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		3 LYS A 505
ARG A 854
LYS A 715
 None
 1.22A 3okxA-3aibA:
undetectable		 3okxA-3aibA:
11.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ax6 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermotoga
maritima) 		PF02222
(ATP-grasp) 		3 LYS A 122
ARG A 140
LYS A 110
 None
 1.42A 3okxA-3ax6A:
undetectable		 3okxA-3ax6A:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		3 LYS A1060
ARG A1054
LYS A 994
 None
 1.49A 3okxA-3bsxA:
undetectable		 3okxA-3bsxA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d43 SPHERICASE

(Lysinibacillus
sphaericus) 		PF00082
(Peptidase_S8) 		3 LYS A 159
ARG A 121
LYS A  52
 None
 1.35A 3okxA-3d43A:
undetectable		 3okxA-3d43A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqq BENZENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas
putida) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		3 LYS A  15
ARG A  48
LYS A 210
 None
 1.46A 3okxA-3eqqA:
undetectable		 3okxA-3eqqA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ffh HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Listeria
innocua) 		PF00155
(Aminotran_1_2) 		3 LYS A 222
ARG A 340
LYS A  17
 SO4  A 361 (-3.5A)
SO4  A 363 (-3.2A)
None
 1.36A 3okxA-3ffhA:
undetectable		 3okxA-3ffhA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h0g DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Schizosaccharomyces
pombe) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		3 LYS A 750
ARG A 538
LYS A 600
 None
 1.33A 3okxA-3h0gA:
undetectable		 3okxA-3h0gA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kh8 MAOC-LIKE
DEHYDRATASE

(Phytophthora
capsici) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		3 LYS A 230
ARG A 226
LYS A 276
 None
 1.20A 3okxA-3kh8A:
undetectable		 3okxA-3kh8A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		3 LYS A  99
ARG A  90
LYS A  79
 None
 1.33A 3okxA-3mn1A:
undetectable		 3okxA-3mn1A:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn8 LP15968P

(Drosophila
melanogaster) 		PF00246
(Peptidase_M14)
PF13620
(CarboxypepD_reg) 		3 LYS A  62
ARG A  85
LYS A 370
 None
 1.37A 3okxA-3mn8A:
undetectable		 3okxA-3mn8A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oet ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		3 LYS A 179
ARG A 208
LYS A  48
 None
 1.41A 3okxA-3oetA:
undetectable		 3okxA-3oetA:
18.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		3 LYS A 143
ARG A 146
LYS A 156
 None
 0.02A 3okxA-3okxA:
27.3		 3okxA-3okxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pta DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		PF00145
(DNA_methylase)
PF01426
(BAH)
PF02008
(zf-CXXC) 		3 LYS A 984
ARG A1337
LYS A 975
 None
 1.14A 3okxA-3ptaA:
undetectable		 3okxA-3ptaA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pzl AGMATINE
UREOHYDROLASE

(Thermoplasma
volcanium) 		PF00491
(Arginase) 		3 LYS A 288
ARG A 255
LYS A 302
 None
 1.31A 3okxA-3pzlA:
undetectable		 3okxA-3pzlA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qb5 TRANSLIN-ASSOCIATED
PROTEIN X

(Homo sapiens) 		PF01997
(Translin) 		3 LYS K  68
ARG K 200
LYS K 241
 SO4  K 294 ( 2.6A)
SO4  K 293 (-3.4A)
None
 1.36A 3okxA-3qb5K:
undetectable		 3okxA-3qb5K:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		3 LYS A 326
ARG A 463
LYS A  11
 None
 1.15A 3okxA-3qr1A:
undetectable		 3okxA-3qr1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		3 LYS A 376
ARG A 369
LYS A 472
 None
 1.31A 3okxA-3snhA:
undetectable		 3okxA-3snhA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zlp THIOREDOXIN
PEROXIDASE

(Schistosoma
mansoni) 		PF00578
(AhpC-TSA)
PF10417
(1-cysPrx_C) 		3 LYS A 143
ARG A 147
LYS A   3
 None
 1.42A 3okxA-3zlpA:
undetectable		 3okxA-3zlpA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		3 LYS A   1
ARG A  24
LYS A 118
 None
 1.17A 3okxA-4c7gA:
undetectable		 3okxA-4c7gA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d51 CYMA

(Klebsiella
oxytoca) 		PF16941
(CymA) 		3 LYS A 201
ARG A 172
LYS A  91
 None
 1.48A 3okxA-4d51A:
undetectable		 3okxA-4d51A:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4es7 PROTEIN AMBP

(Homo sapiens) 		PF00061
(Lipocalin) 		3 LYS A  62
ARG A  36
LYS A 123
 None
 1.34A 3okxA-4es7A:
undetectable		 3okxA-4es7A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hsc STREPTOLYSIN O

(Streptococcus
pyogenes) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 LYS X 496
ARG X 498
LYS X 540
 None
 1.37A 3okxA-4hscX:
undetectable		 3okxA-4hscX:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iyp SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
CATALYTIC SUBUNIT
ALPHA ISOFORM

(Homo sapiens) 		PF00149
(Metallophos) 		3 LYS C   6
ARG C 106
LYS C  41
 None
 1.35A 3okxA-4iypC:
undetectable		 3okxA-4iypC:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lej VICILIN

(Pinus
koraiensis) 		PF00190
(Cupin_1) 		3 LYS A 125
ARG A 103
LYS A 320
 None
 1.13A 3okxA-4lejA:
undetectable		 3okxA-4lejA:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ns4 ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Psychrobacter
cryohalolentis) 		PF00561
(Abhydrolase_1) 		3 LYS A  15
ARG A  59
LYS A 307
 None
 1.44A 3okxA-4ns4A:
undetectable		 3okxA-4ns4A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o8c THERMOSTABLE NPPASE

(Geobacillus
stearothermophilus) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		3 LYS A  56
ARG A  48
LYS A 181
 None
 1.47A 3okxA-4o8cA:
undetectable		 3okxA-4o8cA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		3 LYS A 161
ARG A 168
LYS A  99
 None
 1.09A 3okxA-4p3zA:
undetectable		 3okxA-4p3zA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pue ENDO-1,4-BETA-XYLANA
SE

(Geobacillus
stearothermophilus) 		PF00331
(Glyco_hydro_10) 		3 LYS A 301
ARG A  23
LYS A   9
 ZN  A 409 ( 4.6A)
None
None
 1.47A 3okxA-4pueA:
undetectable		 3okxA-4pueA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 LYS A 370
ARG A 368
LYS A 476
 None
 1.34A 3okxA-4rvwA:
undetectable		 3okxA-4rvwA:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ucl RNA-DIRECTED RNA
POLYMERASE L

(Human
metapneumovirus) 		no annotation 3 LYS A1991
ARG A1662
LYS A1871
 SO4  A2409 (-3.1A)
SO4  A2409 (-3.1A)
None
 1.33A 3okxA-4uclA:
undetectable		 3okxA-4uclA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uj6 SURFACE LAYER
PROTEIN

(Geobacillus
stearothermophilus) 		PF13205
(Big_5) 		3 LYS A 165
ARG A 195
LYS A 207
 None
 1.45A 3okxA-4uj6A:
undetectable		 3okxA-4uj6A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8k CAS1 PROTEIN

(Vibrio phage
ICP1) 		PF01867
(Cas_Cas1) 		3 LYS A 151
ARG A 144
LYS A 189
 None
 1.37A 3okxA-4w8kA:
undetectable		 3okxA-4w8kA:
17.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		3 LYS A  77
ARG A 109
LYS A 143
 None
 1.50A 3okxA-4xjvA:
undetectable		 3okxA-4xjvA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xr7 PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2
PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN3

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
no annotation 		3 LYS G 810
ARG G 859
LYS L 550
 None
 1.03A 3okxA-4xr7G:
undetectable		 3okxA-4xr7G:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anr PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX6

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS B 413
ARG B 421
LYS B 367
 None
 1.15A 3okxA-5anrB:
undetectable		 3okxA-5anrB:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwn DESIGNED HELICAL
REPEAT PROTEIN

(synthetic
construct) 		no annotation 3 LYS A  35
ARG A   9
LYS A  49
 None
 1.48A 3okxA-5cwnA:
undetectable		 3okxA-5cwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d86 PROBABLE SIDEROPHORE
BIOSYNTHESIS PROTEIN
SBNA

(Staphylococcus
aureus) 		PF00291
(PALP) 		3 LYS A 100
ARG A 132
LYS A  47
 None
None
PLP  A1001 (-1.3A)
 1.26A 3okxA-5d86A:
undetectable		 3okxA-5d86A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5de0 DEFERROCHELATASE

(Vibrio cholerae) 		PF04261
(Dyp_perox) 		3 LYS A 150
ARG A 230
LYS A 220
 None
HEM  A 401 (-2.6A)
None
 1.28A 3okxA-5de0A:
undetectable		 3okxA-5de0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 LYS A 312
ARG A 161
LYS A 385
 None
 1.50A 3okxA-5dn6A:
3.0		 3okxA-5dn6A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eyt ADENYLOSUCCINATE
LYASE

(Schistosoma
mansoni) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		3 LYS A  13
ARG A  18
LYS A  29
 None
 1.40A 3okxA-5eytA:
undetectable		 3okxA-5eytA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffn ENZYME SUBTILASE
SUBTY FROM BACILLUS
SP. TY145

(Bacillus sp.
(in: Bacteria)) 		PF00082
(Peptidase_S8) 		3 LYS A 160
ARG A 122
LYS A  53
 None
 1.39A 3okxA-5ffnA:
undetectable		 3okxA-5ffnA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ffo TRANSFORMING GROWTH
FACTOR BETA-1

(Homo sapiens) 		PF00019
(TGF_beta)
PF00688
(TGFb_propeptide) 		3 LYS C  77
ARG C  29
LYS C 319
 None
 1.22A 3okxA-5ffoC:
undetectable		 3okxA-5ffoC:
18.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhx ANTIBODY FRAGMENT
HEAVY-CHAIN
ANTIBODY FRAGMENT
LIGHT CHAIN

(Homo sapiens;
Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF07654
(C1-set)
PF07686
(V-set) 		3 LYS L 306
ARG L 334
LYS H 345
 None
 0.84A 3okxA-5fhxL:
undetectable		 3okxA-5fhxL:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LYS d 198
ARG d 195
LYS d 290
 None
 1.30A 3okxA-5gw5d:
undetectable		 3okxA-5gw5d:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i6h ACETYL-COA
CARBOXYLASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01039
(Carboxyl_trans)
PF08326
(ACC_central) 		3 LYS A1644
ARG A1673
LYS A1534
 None
 1.42A 3okxA-5i6hA:
undetectable		 3okxA-5i6hA:
8.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ik2 ATP SYNTHASE SUBUNIT
ALPHA

(Caldalkalibacillus
thermarum) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		3 LYS A 303
ARG A 161
LYS A 376
 None
 1.48A 3okxA-5ik2A:
3.1		 3okxA-5ik2A:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1
DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB9

(Homo sapiens;
Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF01096
(TFIIS_C)
PF02150
(RNA_POL_M_15KD) 		3 LYS A1306
ARG A1224
LYS I  57
 None
 1.45A 3okxA-5iy9A:
undetectable		 3okxA-5iy9A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		3 LYS A 369
ARG A 333
LYS A 233
 None
 1.46A 3okxA-5ko1A:
1.6		 3okxA-5ko1A:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nxn PORIN 1

(Providencia
stuartii) 		no annotation 3 LYS A  16
ARG A  20
LYS A 278
 None
 1.32A 3okxA-5nxnA:
undetectable		 3okxA-5nxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ool 39S RIBOSOMAL
PROTEIN L35,
MITOCHONDRIAL
39S RIBOSOMAL
PROTEIN L38,
MITOCHONDRIAL

(Homo sapiens;
Homo sapiens) 		PF01632
(Ribosomal_L35p)
PF01161
(PBP) 		3 LYS 6 355
ARG 6 368
LYS 3 126
 None
G  A2860 ( 2.9A)
A  A2869 ( 3.4A)
 1.40A 3okxA-5ool6:
undetectable		 3okxA-5ool6:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x09 V-TYPE ATP SYNTHASE
ALPHA CHAIN,V-TYPE
ATP SYNTHASE ALPHA
CHAIN

(Pyrococcus
horikoshii) 		no annotation 3 LYS A 198
ARG A 320
LYS A 412
 None
 1.36A 3okxA-5x09A:
undetectable		 3okxA-5x09A:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0i KINESIN-LIKE PROTEIN
KLP10A

(Drosophila
melanogaster) 		no annotation 3 LYS K 306
ARG K 330
LYS K 580
 None
 1.27A 3okxA-6b0iK:
undetectable		 3okxA-6b0iK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c6k INTERFERON-INDUCED
PROTEIN WITH
TETRATRICOPEPTIDE
REPEATS 1

(Homo sapiens) 		no annotation 3 LYS A 338
ARG A  40
LYS A 261
 U  E   3 (-2.6A)
A  E   2 (-3.3A)
A  E   4 ( 3.0A)
 1.38A 3okxA-6c6kA:
undetectable		 3okxA-6c6kA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc2 CELL DIVISION
CONTROL PROTEIN 45
CDC45 PUTATIVE

(Entamoeba
histolytica) 		no annotation 3 LYS A 463
ARG A 460
LYS A 291
 EDO  A 612 (-3.4A)
EDO  A 612 (-3.3A)
None
 1.07A 3okxA-6cc2A:
undetectable		 3okxA-6cc2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 3 LYS A 132
ARG A  74
LYS A  -2
 None
 1.27A 3okxA-6dinA:
undetectable		 3okxA-6dinA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6em0 2-HYDROXYBIPHENYL-3-
MONOOXYGENASE

(Pseudomonas
nitroreducens) 		no annotation 3 LYS A 493
ARG A 134
LYS A  68
 None
 1.46A 3okxA-6em0A:
undetectable		 3okxA-6em0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A 595
ARG A 608
LYS A 522
 None
 0.92A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1512
ARG A1507
LYS A1470
 None
 1.44A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6emk SERINE/THREONINE-PRO
TEIN KINASE TOR2

(Saccharomyces
cerevisiae) 		no annotation 3 LYS A1643
ARG A1678
LYS A1656
 None
 1.30A 3okxA-6emkA:
undetectable		 3okxA-6emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkh ATP SYNTHASE SUBUNIT
ALPHA, CHLOROPLASTIC

(Spinacia
oleracea) 		no annotation 3 LYS C 304
ARG C 162
LYS C 377
 None
 1.47A 3okxA-6fkhC:
2.6		 3okxA-6fkhC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bkh MUCONATE LACTONIZING
ENZYME

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 367
ARG A  38
GLY A 308
THR A 309
LEU A 362
 None
 1.11A 3okxB-1bkhA:
0.0		 3okxB-1bkhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 TYR A 192
LEU A 128
PRO A 127
GLY A 141
LEU A  55
 None
 1.27A 3okxB-1dcuA:
0.0		 3okxB-1dcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 LEU P  49
CYH P  38
HIS P  41
LEU P  31
GLY P  32
 None
 1.24A 3okxB-1e33P:
0.0		 3okxB-1e33P:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A 375
TYR A 232
LEU A 368
THR A 364
LEU A 228
 None
 1.32A 3okxB-1i7oA:
0.0		 3okxB-1i7oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN

(Escherichia
coli) 		PF03548
(LolA) 		5 LEU A   6
LEU A  92
GLY A  86
THR A  85
LEU A  10
 None
 0.96A 3okxB-1iwlA:
0.0		 3okxB-1iwlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 PRO A 194
GLY A 189
THR A 188
SER A 187
LEU A 114
 None
 0.96A 3okxB-1m7jA:
0.0		 3okxB-1m7jA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 547
ARG A 571
PRO A 600
GLY A 649
THR A 648
 None
 1.12A 3okxB-1r9jA:
undetectable		 3okxB-1r9jA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s16 TOPOISOMERASE IV
SUBUNIT B

(Escherichia
coli) 		PF00204
(DNA_gyraseB)
PF02518
(HATPase_c) 		5 LEU A1253
CYH A1316
LEU A1368
PRO A1234
LEU A1287
 None
 1.34A 3okxB-1s16A:
0.0		 3okxB-1s16A:
18.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		5 TYR A 193
LEU A 130
PRO A 129
GLY A 143
LEU A  57
 None
 1.05A 3okxB-1spiA:
0.0		 3okxB-1spiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thg LIPASE 2

(Galactomyces
candidus) 		PF00135
(COesterase) 		5 LEU A 297
LEU A 172
ARG A  38
PRO A 168
GLY A 173
 None
 1.29A 3okxB-1thgA:
undetectable		 3okxB-1thgA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		5 LEU X 505
TYR X 437
LEU X 449
ARG X 447
LEU X 444
 None
 1.00A 3okxB-2b5dX:
undetectable		 3okxB-2b5dX:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 289
HIS A 267
LEU A 276
GLY A 320
THR A 319
 None
 1.33A 3okxB-2d5lA:
undetectable		 3okxB-2d5lA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9k PROTEIN MICAL-2

(Homo sapiens) 		PF00307
(CH) 		5 LEU A  60
CYH A  44
GLY A  88
THR A  87
LEU A  41
 None
 1.33A 3okxB-2e9kA:
undetectable		 3okxB-2e9kA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		5 LEU A 285
ARG A 287
GLY A 282
SER A 280
LEU A 250
 None
 1.10A 3okxB-2j1nA:
undetectable		 3okxB-2j1nA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 LEU A 249
GLY A 268
THR A 266
SER A 256
LEU A 346
 None
 1.17A 3okxB-2pggA:
undetectable		 3okxB-2pggA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q8h [PYRUVATE
DEHYDROGENASE
[LIPOAMIDE]] KINASE
ISOZYME 1

(Homo sapiens) 		PF02518
(HATPase_c)
PF10436
(BCDHK_Adom3) 		5 LEU A 239
HIS A 275
GLY A 358
SER A 362
LEU A 352
 None
 1.32A 3okxB-2q8hA:
undetectable		 3okxB-2q8hA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 5 LEU 1  72
HIS 1 191
TYR 1 160
THR 1 161
SER 1 162
 None
 1.20A 3okxB-2ws91:
undetectable		 3okxB-2ws91:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3k ACSD

(Dickeya
chrysanthemi) 		PF04183
(IucA_IucC)
PF06276
(FhuF) 		5 LEU A 426
LEU A 445
GLY A 385
THR A 386
LEU A 511
 None
AMP  A1588 (-4.0A)
None
None
None
 1.29A 3okxB-2x3kA:
undetectable		 3okxB-2x3kA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe5 OUTER MEMBRANE PORIN
C

(Escherichia
coli) 		PF00267
(Porin_1) 		5 LEU A 282
ARG A 284
GLY A 279
SER A 277
LEU A 247
 None
 1.01A 3okxB-2xe5A:
undetectable		 3okxB-2xe5A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 LEU A 113
CYH A  47
HIS A 175
LEU A 150
GLY A 120
 None
 1.31A 3okxB-2yvaA:
undetectable		 3okxB-2yvaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		5 LEU A 162
HIS A 156
GLY A 129
SER A 121
LEU A 160
 None
FE2  A 276 (-3.6A)
None
None
None
 1.33A 3okxB-2zoaA:
undetectable		 3okxB-2zoaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0b CENTROMERE PROTEIN S
CENTROMERE PROTEIN X

(Gallus gallus;
Gallus gallus) 		no annotation
PF09415
(CENP-X) 		5 LEU B  12
LEU C  16
ARG C  15
THR B  51
SER B  48
 None
 1.25A 3okxB-3b0bB:
undetectable		 3okxB-3b0bB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb8 CDP-4-KETO-6-DEOXY-D
-GLUCOSE-3-DEHYDRASE

(Yersinia
pseudotuberculosis) 		PF01041
(DegT_DnrJ_EryC1) 		5 ARG A 359
PRO A 348
GLY A 412
SER A  37
LEU A 375
 None
 1.29A 3okxB-3bb8A:
undetectable		 3okxB-3bb8A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8i PUTATIVE MEMBRANE
PROTEIN

(Corynebacterium
diphtheriae) 		PF11580
(DUF3239) 		5 LEU A  49
LEU A 125
GLY A  68
THR A  69
LEU A  34
 None
 1.27A 3okxB-3c8iA:
undetectable		 3okxB-3c8iA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 LEU A 196
CYH A 172
TYR A 179
LEU A 223
LEU A 181
 None
 1.18A 3okxB-3e02A:
undetectable		 3okxB-3e02A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 LEU A 196
HIS A 215
TYR A 179
LEU A 223
LEU A 181
 None
 1.33A 3okxB-3e02A:
undetectable		 3okxB-3e02A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcp L-ALA-D/L-GLU
EPIMERASE, A
MUCONATE LACTONIZING
ENZYME

(Klebsiella
pneumoniae) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 367
ARG A  39
GLY A 309
THR A 310
LEU A 362
 None
 1.21A 3okxB-3fcpA:
undetectable		 3okxB-3fcpA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fj4 MUCONATE
CYCLOISOMERASE

(Pseudomonas
protegens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 369
ARG A  40
GLY A 310
THR A 311
LEU A 364
 None
 1.02A 3okxB-3fj4A:
undetectable		 3okxB-3fj4A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		5 LEU A   8
HIS A 201
LEU A  45
PRO A 175
LEU A   5
 None
 1.34A 3okxB-3ix6A:
undetectable		 3okxB-3ix6A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kba PROGESTERONE
RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 782
HIS A 770
LEU A 763
GLY A 764
LEU A 784
 None
None
WOW  A   1 ( 4.0A)
None
None
 1.15A 3okxB-3kbaA:
undetectable		 3okxB-3kbaA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7m 33 KDA CHAPERONIN

(Escherichia
coli) 		PF01430
(HSP33) 		5 LEU X 202
ARG X 213
GLY X 170
SER X  27
LEU X 205
 None
 1.09A 3okxB-3m7mX:
undetectable		 3okxB-3m7mX:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3moi PROBABLE
DEHYDROGENASE

(Bordetella
bronchiseptica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 369
HIS A 181
PRO A  96
GLY A 121
THR A 122
 None
 1.22A 3okxB-3moiA:
undetectable		 3okxB-3moiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw8 UROPORPHYRINOGEN-III
SYNTHASE

(Shewanella
amazonensis) 		PF02602
(HEM4) 		5 LEU A 158
CYH A 155
THR A 178
SER A 179
LEU A 189
 None
None
None
EDO  A 301 (-3.7A)
None
 1.14A 3okxB-3mw8A:
undetectable		 3okxB-3mw8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9y ADRENODOXIN

(Homo sapiens) 		PF00111
(Fer2) 		5 LEU C  30
GLY C  48
THR C  49
CYH C  55
LEU C  57
 None
FES  C 150 (-4.0A)
None
FES  C 150 (-2.1A)
None
 1.27A 3okxB-3n9yC:
undetectable		 3okxB-3n9yC:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 744
GLY A 703
THR A 704
CYH A 753
LEU A 757
 None
 0.87A 3okxB-3nawA:
undetectable		 3okxB-3nawA:
15.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nv9 MALIC ENZYME

(Entamoeba
histolytica) 		PF00390
(malic)
PF03949
(Malic_M) 		5 LEU A 390
ARG A 388
GLY A 406
THR A 407
LEU A 207
 None
 1.23A 3okxB-3nv9A:
undetectable		 3okxB-3nv9A:
15.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		10 HIS A  43
TYR A  76
LEU A  78
ARG A  80
PRO A 105
GLY A 112
THR A 113
SER A 114
CYH A 133
LEU A 134
 SAM  A 201 (-4.2A)
None
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.8A)
SAM  A 201 (-3.6A)
SAM  A 201 (-4.2A)
SAM  A 201 ( 3.9A)
None
SAM  A 201 (-4.2A)
 0.80A 3okxB-3okxA:
23.9		 3okxB-3okxA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		11 LEU A  37
CYH A  40
HIS A  43
TYR A  76
LEU A  78
PRO A 105
GLY A 112
THR A 113
SER A 114
CYH A 133
LEU A 134
 SAM  A 201 (-4.5A)
SAM  A 201 (-4.0A)
SAM  A 201 (-4.2A)
None
SAM  A 201 (-4.1A)
SAM  A 201 (-3.8A)
SAM  A 201 (-3.6A)
SAM  A 201 (-4.2A)
SAM  A 201 ( 3.9A)
None
SAM  A 201 (-4.2A)
 0.16A 3okxB-3okxA:
23.9		 3okxB-3okxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E

(Proteus
mirabilis) 		PF00582
(Usp) 		5 LEU A 233
HIS A 169
LEU A 176
GLY A 270
LEU A 195
 None
 1.31A 3okxB-3olqA:
undetectable		 3okxB-3olqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		5 LEU A 323
LEU A 387
GLY A 405
THR A 404
LEU A 365
 None
 1.27A 3okxB-3om5A:
undetectable		 3okxB-3om5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3op0 SIGNAL TRANSDUCTION
PROTEIN CBL-C

(Homo sapiens) 		PF02262
(Cbl_N)
PF02761
(Cbl_N2)
PF02762
(Cbl_N3) 		5 LEU A 322
HIS A 183
PRO A 220
THR A 215
LEU A 231
 None
CSO  A 182 ( 3.9A)
None
None
None
 1.31A 3okxB-3op0A:
undetectable		 3okxB-3op0A:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 LEU A 196
GLY A 146
THR A 147
SER A 148
LEU A 304
 None
None
BAU  A 400 (-4.5A)
None
None
 1.30A 3okxB-3p0fA:
undetectable		 3okxB-3p0fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8c NCK-ASSOCIATED
PROTEIN 1

(Homo sapiens) 		PF09735
(Nckap1) 		5 LEU B 596
ARG B 594
THR B 701
CYH B 599
LEU B 598
 GOL  B1132 ( 4.3A)
None
None
None
None
 1.30A 3okxB-3p8cB:
undetectable		 3okxB-3p8cB:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pz2 GERANYLGERANYL
TRANSFERASE TYPE-2
SUBUNIT BETA

(Rattus
norvegicus) 		PF00432
(Prenyltrans) 		5 LEU B 298
LEU B 263
ARG B 264
GLY B 228
LEU B 268
 None
 1.26A 3okxB-3pz2B:
undetectable		 3okxB-3pz2B:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr1 PHOSPHOLIPASE C-BETA
(PLC-BETA)

(Doryteuthis
pealeii) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		5 LEU A  29
GLY A  91
THR A  92
CYH A 105
LEU A 122
 None
 1.24A 3okxB-3qr1A:
undetectable		 3okxB-3qr1A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 LEU A 191
CYH A 195
LEU A  14
GLY A  24
THR A  25
 None
 1.24A 3okxB-3rd7A:
undetectable		 3okxB-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 LEU A 106
HIS A  14
GLY A 177
SER A  41
LEU A  84
 None
 0.95A 3okxB-3rksA:
undetectable		 3okxB-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
 1.33A 3okxB-3rksA:
undetectable		 3okxB-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		5 LEU A 181
ARG A 250
THR A 190
SER A 191
LEU A 242
 None
None
ACO  A 300 (-3.7A)
None
None
 1.29A 3okxB-3smaA:
undetectable		 3okxB-3smaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		5 LEU A 113
HIS A  21
TYR A  64
SER A  48
LEU A  91
 None
 1.22A 3okxB-3sttA:
undetectable		 3okxB-3sttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swo GLUTARYL-COA
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  43
LEU A  67
ARG A  42
GLY A  68
LEU A  60
 None
 1.25A 3okxB-3swoA:
undetectable		 3okxB-3swoA:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		5 LEU A 413
LEU A 521
PRO A 493
THR A 524
LEU A 514
 None
 1.33A 3okxB-3ua4A:
undetectable		 3okxB-3ua4A:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		5 LEU A  85
HIS A  91
LEU A  35
THR A  29
LEU A  80
 None
 1.25A 3okxB-3uitA:
undetectable		 3okxB-3uitA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 182
TYR A 164
GLY A 162
SER A 234
CYH A 176
 None
 1.33A 3okxB-3ujkA:
undetectable		 3okxB-3ujkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 LEU B 266
TYR B 202
LEU B 208
GLY B 204
SER B 194
 None
None
None
None
F3S  B 303 (-4.4A)
 1.34A 3okxB-3vrbB:
undetectable		 3okxB-3vrbB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 LEU A 362
ARG A 272
GLY A 356
THR A 357
LEU A 419
 None
 1.16A 3okxB-3wvrA:
undetectable		 3okxB-3wvrA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9p TYPE 3A
CELLULOSE-BINDING
DOMAIN PROTEIN

(Ruminiclostridium
thermocellum) 		PF00942
(CBM_3) 		6 LEU A 117
TYR A  48
LEU A  23
ARG A 110
THR A  49
SER A  86
 None
None
None
None
CA  A1167 (-3.6A)
None
 1.48A 3okxB-4b9pA:
undetectable		 3okxB-4b9pA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c90 ALPHA-GLUCURONIDASE
GH115

(Bacteroides
ovatus) 		PF15979
(Glyco_hydro_115) 		5 LEU A 623
LEU A 585
ARG A 619
GLY A 527
THR A 526
 None
 1.30A 3okxB-4c90A:
undetectable		 3okxB-4c90A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 LEU C 253
TYR C 133
GLY C 208
THR C 207
LEU C 257
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.19A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxB-4ci0C:
undetectable		 3okxB-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A 228
PRO A 227
GLY A 229
THR A 231
SER A 232
 None
 1.33A 3okxB-4czpA:
undetectable		 3okxB-4czpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d74 PROTEIN-TYROSINE-PHO
SPHATASE AMSI

(Erwinia
amylovora) 		PF01451
(LMWPc) 		5 LEU A  68
HIS A  63
GLY A  19
THR A  18
CYH A   9
 None
None
None
None
SO4  A1145 (-3.2A)
 1.33A 3okxB-4d74A:
undetectable		 3okxB-4d74A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 TYR A 152
LEU A 151
ARG A 144
PRO A 138
GLY A 110
 None
 1.33A 3okxB-4eelA:
undetectable		 3okxB-4eelA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 LEU B 163
TYR A 130
PRO B 176
GLY A 132
THR A 133
 None
 1.07A 3okxB-4gh4B:
undetectable		 3okxB-4gh4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxB-4grhA:
undetectable		 3okxB-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 119
CYH A 152
LEU A 117
SER A 361
LEU A 115
 None
 1.27A 3okxB-4grvA:
undetectable		 3okxB-4grvA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gua NON-STRUCTURAL
POLYPROTEIN

(Sindbis virus) 		PF01661
(Macro)
PF01707
(Peptidase_C9) 		5 CYH A1474
PRO A1418
GLY A1400
THR A1401
LEU A1658
 None
 1.23A 3okxB-4guaA:
undetectable		 3okxB-4guaA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		5 LEU A  63
HIS A 122
LEU A 151
GLY A  37
LEU A 142
 None
 1.25A 3okxB-4hvmA:
undetectable		 3okxB-4hvmA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  73
HIS A 294
GLY A  46
SER A  48
LEU A  76
 None
 1.25A 3okxB-4it1A:
undetectable		 3okxB-4it1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1y COMPLEMENT C1S
SUBCOMPONENT

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin) 		5 TYR A 665
LEU A 587
ARG A 586
GLY A 663
LEU A 566
 None
 1.11A 3okxB-4j1yA:
0.7		 3okxB-4j1yA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		5 LEU A 104
HIS A 197
TYR A  16
LEU A  24
PRO A  31
 None
 1.01A 3okxB-4lanA:
undetectable		 3okxB-4lanA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1b TOLUENE-4-MONOOXYGEN
ASE SYSTEM
FERREDOXIN SUBUNIT

(Pseudomonas
mendocina) 		PF00355
(Rieske) 		5 LEU H  86
HIS H  36
TYR H  57
GLY H  60
LEU H  52
 None
 1.27A 3okxB-4p1bH:
undetectable		 3okxB-4p1bH:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p62 METALLO-BETA-LACTAMA
SE AIM-1

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A 285
HIS A 104
ARG A 232
THR A 187
SER A 188
 None
ZN  A 301 (-3.2A)
None
None
None
 1.34A 3okxB-4p62A:
undetectable		 3okxB-4p62A:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw5 E3 UBIQUITIN-PROTEIN
LIGASE UHRF2

(Homo sapiens) 		PF02182
(SAD_SRA) 		5 LEU A 545
ARG A 535
GLY A 509
THR A 508
LEU A 539
 None
 1.29A 3okxB-4pw5A:
1.8		 3okxB-4pw5A:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A 327
TYR A 339
GLY A 288
THR A 289
SER A 290
 None
None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.6A)
 0.95A 3okxB-4rg1A:
undetectable		 3okxB-4rg1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 281
LEU A 275
GLY A 251
THR A 252
LEU A 302
 None
 1.03A 3okxB-4v2dA:
undetectable		 3okxB-4v2dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  77
LEU A 299
PRO A 254
GLY A 330
THR A 331
 None
 1.34A 3okxB-4x28A:
undetectable		 3okxB-4x28A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yer ABC TRANSPORTER
ATP-BINDING PROTEIN

(Thermotoga
maritima) 		PF00005
(ABC_tran)
PF13732
(DUF4162) 		5 CYH A 251
HIS A 300
TYR A 233
LEU A 254
LEU A 259
 None
 1.24A 3okxB-4yerA:
undetectable		 3okxB-4yerA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 CYH A 273
HIS A 254
LEU A 417
ARG A 415
THR A 317
 None
 1.20A 3okxB-5affA:
undetectable		 3okxB-5affA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aff SYMPORTIN 1

(Chaetomium
thermophilum) 		no annotation 5 CYH A 273
LEU A 417
ARG A 415
GLY A 316
THR A 317
 None
 1.03A 3okxB-5affA:
undetectable		 3okxB-5affA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		5 LEU A 191
CYH A 217
LEU A 259
GLY A 241
LEU A 199
 None
 1.30A 3okxB-5bncA:
1.5		 3okxB-5bncA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c41 RIBOKINASE

(Homo sapiens) 		PF00294
(PfkB) 		5 LEU A 206
CYH A 198
ARG A 227
THR A 174
LEU A 224
 None
 1.31A 3okxB-5c41A:
undetectable		 3okxB-5c41A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 TYR A 186
LEU A 184
GLY A 196
THR A 195
CYH A 126
 None
 1.19A 3okxB-5d6nA:
undetectable		 3okxB-5d6nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dh2 SIDEROPHORE
PERIPLASMIC BINDING
PROTEIN

(Thermobifida
fusca) 		PF01497
(Peripla_BP_2) 		5 LEU A 203
ARG A 205
GLY A 103
THR A 104
LEU A 201
 None
 1.29A 3okxB-5dh2A:
undetectable		 3okxB-5dh2A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A 285
CYH A 282
GLY A  70
THR A  71
LEU A  25
 None
 1.34A 3okxB-5dt9A:
undetectable		 3okxB-5dt9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsh CSM6

(Thermus
thermophilus) 		PF09670
(Cas_Cas02710) 		5 LEU A  33
ARG A  38
GLY A 177
THR A 178
LEU A  69
 None
 1.20A 3okxB-5fshA:
undetectable		 3okxB-5fshA:
17.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gsm EXO-BETA-D-GLUCOSAMI
NIDASE

(Thermococcus
kodakarensis) 		PF02449
(Glyco_hydro_42) 		5 LEU A  40
ARG A  43
GLY A  23
THR A  24
LEU A  88
 None
 1.33A 3okxB-5gsmA:
undetectable		 3okxB-5gsmA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hcc COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF07677
(A2M_recep)
PF07678
(A2M_comp) 		5 LEU A1255
ARG A1226
GLY A1296
THR A1298
SER A1301
 None
 1.24A 3okxB-5hccA:
undetectable		 3okxB-5hccA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 836
ARG A 834
GLY A 847
THR A 848
SER A 849
 None
IHP  A1201 (-3.7A)
None
None
None
 1.30A 3okxB-5hdtA:
undetectable		 3okxB-5hdtA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz1 FRUCTOSE-1,6-BISPHOS
PHATASE

(Physcomitrella
patens) 		PF00316
(FBPase) 		5 TYR A 260
LEU A 199
PRO A 198
GLY A 212
LEU A 126
 None
 1.15A 3okxB-5iz1A:
undetectable		 3okxB-5iz1A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 5 LEU A 197
CYH A 192
PRO A 153
GLY A 124
LEU A 202
 None
 1.31A 3okxB-5lf9A:
undetectable		 3okxB-5lf9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 TYR A 273
LEU A  41
PRO A  42
SER A 264
LEU A 275
 None
None
None
None
GOL  A 403 ( 4.6A)
 1.27A 3okxB-5m86A:
undetectable		 3okxB-5m86A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t8v PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF12765
(Cohesin_HEAT)
PF12830
(Nipped-B_C) 		5 LEU A1059
LEU A1001
GLY A 841
THR A 842
LEU A1017
 None
 1.31A 3okxB-5t8vA:
undetectable		 3okxB-5t8vA:
7.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 LEU A 106
HIS A  14
GLY A 176
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 0.94A 3okxB-5tdxA:
undetectable		 3okxB-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 1.21A 3okxB-5tdxA:
undetectable		 3okxB-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgc DAUNORUBICIN-DOXORUB
ICIN POLYKETIDE
SYNTHASE

(Streptomyces
peucetius) 		no annotation 5 LEU A  30
LEU A  39
ARG A  37
GLY A 162
THR A 163
 None
None
None
None
AFY  A 401 (-3.4A)
 1.17A 3okxB-5wgcA:
undetectable		 3okxB-5wgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		5 LEU A 965
LEU A 944
GLY A 976
THR A 977
SER A 978
 None
 1.16A 3okxB-5wqwA:
undetectable		 3okxB-5wqwA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bng 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Acinetobacter
baumannii) 		no annotation 5 TYR A  45
LEU A  25
GLY A  27
SER A 242
LEU A  52
 None
 1.10A 3okxB-6bngA:
undetectable		 3okxB-6bngA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 5 LEU B 287
LEU B 261
GLY B 260
THR B 259
SER B 275
 None
 1.24A 3okxB-6ckcB:
undetectable		 3okxB-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 LEU A 807
ARG A 808
GLY A 769
THR A 770
LEU A 841
 None
 1.31A 3okxB-6ez8A:
undetectable		 3okxB-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 HIS A 110
SER A 132
ASP A 339
THR A 315
 FMN  A4001 ( 3.8A)
EPS  A5001 (-3.5A)
FMN  A4001 ( 4.9A)
FMN  A4001 (-2.9A)
 1.07A 3okxB-1qxoA:
0.0		 3okxB-1qxoA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 344
ARG A 251
ASP A 116
THR A 267
 None
 1.40A 3okxB-1v5vA:
1.9		 3okxB-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5v AMINOMETHYLTRANSFERA
SE

(Pyrococcus
horikoshii) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		4 SER A 344
ARG A 251
ASP A 118
THR A 267
 None
 1.44A 3okxB-1v5vA:
1.9		 3okxB-1v5vA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w1k VANILLYL-ALCOHOL
OXIDASE

(Penicillium
simplicissimum) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 HIS A 466
SER A 426
ASP A 170
THR A 459
 EUG  A1562 ( 4.8A)
EUG  A1562 ( 4.8A)
FAD  A1561 ( 3.6A)
EUG  A1562 ( 4.0A)
 1.47A 3okxB-1w1kA:
undetectable		 3okxB-1w1kA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y30 HYPOTHETICAL PROTEIN
RV1155

(Mycobacterium
tuberculosis) 		PF01243
(Putative_PNPOx) 		4 SER A  50
ARG A 121
ASP A  97
THR A  89
 None
 1.48A 3okxB-1y30A:
2.0		 3okxB-1y30A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		4 HIS A 525
SER A 645
ARG A 383
THR A 679
 None
None
CL  A1739 (-4.6A)
None
 1.35A 3okxB-2c11A:
0.0		 3okxB-2c11A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		4 HIS A 434
ARG A 591
ASP A   8
THR A  77
 None
ADP  A1001 (-3.3A)
MG  A1003 ( 4.1A)
None
 0.97A 3okxB-2d0oA:
1.2		 3okxB-2d0oA:
14.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hdw HYPOTHETICAL PROTEIN
PA2218

(Pseudomonas
aeruginosa) 		PF02129
(Peptidase_S15) 		4 HIS A 264
ARG A 353
ASP A 349
THR A 269
 None
 1.38A 3okxB-2hdwA:
0.0		 3okxB-2hdwA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		4 SER A 172
ARG A 160
ASP A 399
THR A 166
 None
2A3  A 602 (-3.0A)
None
None
 1.41A 3okxB-3anyA:
0.0		 3okxB-3anyA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3if6 OXA-46 OXACILLINASE

(Pseudomonas
aeruginosa) 		PF00905
(Transpeptidase) 		4 HIS C  78
SER C  72
ARG C 216
ASP C 161
 None
KCX  C  75 ( 2.7A)
None
None
 1.48A 3okxB-3if6C:
0.0		 3okxB-3if6C:
21.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		4 SER A  81
ARG A 103
ASP A 132
THR A 137
 SAM  A 201 (-3.1A)
SAM  A 201 (-4.0A)
SAM  A 201 (-3.1A)
SAM  A 201 (-3.2A)
 0.07A 3okxB-3okxA:
23.9		 3okxB-3okxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rij SC_2CX5

(Thermus
thermophilus) 		PF04073
(tRNA_edit) 		4 HIS A 108
ARG A 134
ASP A  99
THR A  96
 None
 1.49A 3okxB-3rijA:
undetectable		 3okxB-3rijA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rqb UNCHARACTERIZED
PROTEIN

(Alicyclobacillus
acidocaldarius) 		PF13622
(4HBT_3) 		4 HIS A 118
ARG A 221
ASP A 253
THR A 119
 None
 1.48A 3okxB-3rqbA:
undetectable		 3okxB-3rqbA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uk2 PANTOTHENATE
SYNTHETASE

(Burkholderia
thailandensis) 		PF02569
(Pantoate_ligase) 		4 HIS A 227
SER A 229
ARG A 272
THR A 202
 None
 1.27A 3okxB-3uk2A:
undetectable		 3okxB-3uk2A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3viu PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE 2

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 HIS A 274
SER A 276
ARG A 336
THR A 357
 None
 1.38A 3okxB-3viuA:
undetectable		 3okxB-3viuA:
13.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgy DNA TOPOISOMERASE
3-ALPHA

(Homo sapiens) 		PF01131
(Topoisom_bac)
PF01751
(Toprim) 		4 SER A 361
ARG A 177
ASP A 411
THR A 329
 None
 1.45A 3okxB-4cgyA:
undetectable		 3okxB-4cgyA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4efz METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Burkholderia
pseudomallei) 		PF00753
(Lactamase_B) 		4 HIS A 212
SER A  15
ASP A  34
THR A  11
 None
 1.29A 3okxB-4efzA:
undetectable		 3okxB-4efzA:
25.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gk8 HISTIDINOL-PHOSPHATA
SE

(Lactococcus
lactis) 		PF02811
(PHP) 		4 HIS A  11
SER A 229
ARG A 243
THR A  40
 ZN  A 303 ( 3.3A)
None
CL  A 306 ( 4.8A)
None
 1.34A 3okxB-4gk8A:
undetectable		 3okxB-4gk8A:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ogc HNH ENDONUCLEASE
DOMAIN PROTEIN

(Actinomyces
naeslundii) 		PF01844
(HNH) 		4 HIS A  21
ARG A 527
ASP A 509
THR A  20
 None
 1.47A 3okxB-4ogcA:
undetectable		 3okxB-4ogcA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 SER A 120
ARG A  28
ASP A 109
THR A  56
 None
 1.42A 3okxB-4p9nA:
undetectable		 3okxB-4p9nA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 4 HIS A 385
SER A 394
ASP A 399
THR A 384
 None
 1.26A 3okxB-4po6A:
undetectable		 3okxB-4po6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE
DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A''
DNA-DIRECTED RNA
POLYMERASE SUBUNIT H

(Thermococcus
kodakarensis;
Thermococcus
kodakarensis;
Thermococcus
kodakarensis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF04998
(RNA_pol_Rpb1_5)
PF01191
(RNA_pol_Rpb5_C) 		4 SER H  67
ARG C 294
ASP C 301
THR A 887
 None
 1.44A 3okxB-4qiwH:
undetectable		 3okxB-4qiwH:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y0i 4-AMINOBUTYRATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Sus scrofa) 		PF00202
(Aminotran_3) 		4 HIS A 201
SER A 202
ASP A 298
THR A 199
 None
None
PSZ  A 501 (-2.8A)
None
 1.27A 3okxB-4y0iA:
undetectable		 3okxB-4y0iA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysl BETA-LACTAMASE
DOMAIN PROTEIN

(Pseudomonas
putida) 		PF00753
(Lactamase_B) 		4 HIS A 212
SER A  21
ASP A  40
THR A  17
 GSH  A 302 ( 4.8A)
None
None
None
 1.21A 3okxB-4yslA:
undetectable		 3okxB-4yslA:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giv CARBOXYPEPTIDASE 1

(Deinococcus
radiodurans) 		PF02074
(Peptidase_M32) 		4 SER A 346
ARG A 251
ASP A 256
THR A 342
 None
 1.39A 3okxB-5givA:
undetectable		 3okxB-5givA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gll GLYCOSIDE HYDROLASE
FAMILY 43

(uncultured
bacterium) 		PF04616
(Glyco_hydro_43) 		4 HIS A 334
SER A  72
ARG A 122
THR A 317
 None
GOL  A 403 ( 4.5A)
None
GOL  A 403 (-4.0A)
 1.22A 3okxB-5gllA:
undetectable		 3okxB-5gllA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihr PROBABLE
BETA-GALACTOSIDASE A

(Aspergillus
niger) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 HIS A 432
SER A 433
ASP A 410
THR A 441
 None
 1.18A 3okxB-5ihrA:
undetectable		 3okxB-5ihrA:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iud DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 HIS A 637
SER A 709
ARG A1082
ASP A1173
 None
 1.50A 3okxB-5iudA:
undetectable		 3okxB-5iudA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0t METHIONINE--TRNA
LIGASE

(Brucella suis) 		PF08264
(Anticodon_1)
PF09334
(tRNA-synt_1g) 		4 HIS A 101
SER A  97
ASP A  92
THR A 239
 None
 1.33A 3okxB-5k0tA:
undetectable		 3okxB-5k0tA:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5njf METALLOPROTEASE PMBA

(Escherichia
coli) 		PF01523
(PmbA_TldD) 		4 HIS B 187
SER B 214
ASP B 125
THR B 185
 None
 1.36A 3okxB-5njfB:
undetectable		 3okxB-5njfB:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u70 POTASSIUM CHANNEL
SUBFAMILY T MEMBER 1

(Gallus gallus) 		PF03493
(BK_channel_a)
PF07885
(Ion_trans_2) 		4 SER A 516
ARG A 923
ASP A 367
THR A 510
 None
 1.41A 3okxB-5u70A:
undetectable		 3okxB-5u70A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xfa NAD-REDUCING
HYDROGENASE

(Hydrogenophilus
thermoluteolus) 		PF01257
(2Fe-2S_thioredx)
PF01512
(Complex1_51K)
PF10589
(NADH_4Fe-4S) 		4 HIS A  66
ARG A 128
ASP A  73
THR A 107
 None
 1.47A 3okxB-5xfaA:
undetectable		 3okxB-5xfaA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 HIS A 275
SER A 273
ASP A 244
THR A 258
 None
 1.34A 3okxB-6bfuA:
undetectable		 3okxB-6bfuA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gh2 LAMINARIBIOSE
PHOSPHORYLASE

(Paenibacillus
sp. YM1) 		no annotation 4 HIS A 433
ARG A 472
ASP A 463
THR A 410
 None
 1.47A 3okxB-6gh2A:
undetectable		 3okxB-6gh2A:
undetectable