SIMILAR PATTERNS OF AMINO ACIDS FOR 3OKX_A_SAMA201_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qxo | CHORISMATE SYNTHASE (Streptococcuspneumoniae) |
PF01264(Chorismate_synt) | 4 | HIS A 110SER A 132ASP A 339THR A 315 | FMN A4001 ( 3.8A)EPS A5001 (-3.5A)FMN A4001 ( 4.9A)FMN A4001 (-2.9A) | 1.12A | 3okxA-1qxoA:0.0 | 3okxA-1qxoA:19.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | SER A 344ARG A 251ASP A 116THR A 267 | None | 1.40A | 3okxA-1v5vA:0.4 | 3okxA-1v5vA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v5v | AMINOMETHYLTRANSFERASE (Pyrococcushorikoshii) |
PF01571(GCV_T)PF08669(GCV_T_C) | 4 | SER A 344ARG A 251ASP A 118THR A 267 | None | 1.44A | 3okxA-1v5vA:0.4 | 3okxA-1v5vA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v6y | ENDO-1,4-BETA-D-XYLANASE ANDENDO-1,4-BETA-XYLANASE B (Cellulomonasfimi;Streptomycesolivaceoviridis) |
PF00331(Glyco_hydro_10) | 4 | SER A 206ARG A 218ASP A 216THR A 182 | None | 1.40A | 3okxA-1v6yA:0.0 | 3okxA-1v6yA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y30 | HYPOTHETICAL PROTEINRV1155 (Mycobacteriumtuberculosis) |
PF01243(Putative_PNPOx) | 4 | SER A 50ARG A 121ASP A 97THR A 89 | None | 1.48A | 3okxA-1y30A:1.7 | 3okxA-1y30A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2d0o | DIOLDEHYDRATASE-REACTIVATING FACTOR LARGESUBUNIT (Klebsiellaoxytoca) |
PF08841(DDR) | 4 | HIS A 434ARG A 591ASP A 8THR A 77 | NoneADP A1001 (-3.3A) MG A1003 ( 4.1A)None | 0.98A | 3okxA-2d0oA:0.0 | 3okxA-2d0oA:14.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3any | ETHANOLAMINEAMMONIA-LYASE HEAVYCHAIN (Escherichiacoli) |
PF06751(EutB) | 4 | SER A 172ARG A 160ASP A 399THR A 166 | None2A3 A 602 (-3.0A)NoneNone | 1.39A | 3okxA-3anyA:0.0 | 3okxA-3anyA:16.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3if6 | OXA-46 OXACILLINASE (Pseudomonasaeruginosa) |
PF00905(Transpeptidase) | 4 | HIS C 78SER C 72ARG C 216ASP C 161 | NoneKCX C 75 ( 2.7A)NoneNone | 1.48A | 3okxA-3if6C:0.0 | 3okxA-3if6C:21.63 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3okx | YAEB-LIKE PROTEINRPA0152 (Rhodopseudomonaspalustris) |
PF01980(UPF0066) | 4 | SER A 81ARG A 103ASP A 132THR A 137 | SAM A 201 (-3.1A)SAM A 201 (-4.0A)SAM A 201 (-3.1A)SAM A 201 (-3.2A) | 0.00A | 3okxA-3okxA:27.3 | 3okxA-3okxA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rqb | UNCHARACTERIZEDPROTEIN (Alicyclobacillusacidocaldarius) |
PF13622(4HBT_3) | 4 | HIS A 118ARG A 221ASP A 253THR A 119 | None | 1.44A | 3okxA-3rqbA:0.0 | 3okxA-3rqbA:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uk2 | PANTOTHENATESYNTHETASE (Burkholderiathailandensis) |
PF02569(Pantoate_ligase) | 4 | HIS A 227SER A 229ARG A 272THR A 202 | None | 1.31A | 3okxA-3uk2A:undetectable | 3okxA-3uk2A:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3viu | PHOSPHORIBOSYLFORMYLGLYCINAMIDINESYNTHASE 2 (Thermusthermophilus) |
PF00586(AIRS)PF02769(AIRS_C) | 4 | HIS A 274SER A 276ARG A 336THR A 357 | None | 1.37A | 3okxA-3viuA:undetectable | 3okxA-3viuA:13.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cgy | DNA TOPOISOMERASE3-ALPHA (Homo sapiens) |
PF01131(Topoisom_bac)PF01751(Toprim) | 4 | SER A 361ARG A 177ASP A 411THR A 329 | None | 1.47A | 3okxA-4cgyA:undetectable | 3okxA-4cgyA:14.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gk8 | HISTIDINOL-PHOSPHATASE (Lactococcuslactis) |
PF02811(PHP) | 4 | HIS A 11SER A 229ARG A 243THR A 40 | ZN A 303 ( 3.3A)None CL A 306 ( 4.8A)None | 1.41A | 3okxA-4gk8A:undetectable | 3okxA-4gk8A:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mcx | ANTIDOTE PROTEINKILLER PROTEIN (Proteusvulgaris;Proteusvulgaris) |
PF01381(HTH_3)PF05015(HigB-like_toxin) | 4 | HIS A 8SER A 7ARG B 29ASP A 16 | None | 1.26A | 3okxA-4mcxA:undetectable | 3okxA-4mcxA:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ogc | HNH ENDONUCLEASEDOMAIN PROTEIN (Actinomycesnaeslundii) |
PF01844(HNH) | 4 | HIS A 21ARG A 527ASP A 509THR A 20 | None | 1.47A | 3okxA-4ogcA:undetectable | 3okxA-4ogcA:10.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p9n | CARBOXYLESTERASE (Sulfolobusshibatae) |
PF07859(Abhydrolase_3) | 4 | SER A 120ARG A 28ASP A 109THR A 56 | None | 1.39A | 3okxA-4p9nA:undetectable | 3okxA-4p9nA:19.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASEDNA-DIRECTED RNAPOLYMERASE SUBUNITA''DNA-DIRECTED RNAPOLYMERASE SUBUNIT H (Thermococcuskodakarensis;Thermococcuskodakarensis;Thermococcuskodakarensis) |
PF00623(RNA_pol_Rpb1_2)PF04983(RNA_pol_Rpb1_3)PF04997(RNA_pol_Rpb1_1)PF04998(RNA_pol_Rpb1_5)PF05000(RNA_pol_Rpb1_4)PF04998(RNA_pol_Rpb1_5)PF01191(RNA_pol_Rpb5_C) | 4 | SER H 67ARG C 294ASP C 301THR A 887 | None | 1.46A | 3okxA-4qiwH:undetectable | 3okxA-4qiwH:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xpu | ENDONUCLEASE V (Escherichiacoli) |
PF04493(Endonuclease_5) | 4 | HIS A 109SER A 108ARG A 197ASP A 103 | None | 1.12A | 3okxA-4xpuA:undetectable | 3okxA-4xpuA:26.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y0i | 4-AMINOBUTYRATEAMINOTRANSFERASE,MITOCHONDRIAL (Sus scrofa) |
PF00202(Aminotran_3) | 4 | HIS A 201SER A 202ASP A 298THR A 199 | NoneNonePSZ A 501 (-2.8A)None | 1.28A | 3okxA-4y0iA:undetectable | 3okxA-4y0iA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysl | BETA-LACTAMASEDOMAIN PROTEIN (Pseudomonasputida) |
PF00753(Lactamase_B) | 4 | HIS A 212SER A 21ASP A 40THR A 17 | GSH A 302 ( 4.8A)NoneNoneNone | 1.20A | 3okxA-4yslA:undetectable | 3okxA-4yslA:23.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5giv | CARBOXYPEPTIDASE 1 (Deinococcusradiodurans) |
PF02074(Peptidase_M32) | 4 | SER A 346ARG A 251ASP A 256THR A 342 | None | 1.40A | 3okxA-5givA:undetectable | 3okxA-5givA:15.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gll | GLYCOSIDE HYDROLASEFAMILY 43 (unculturedbacterium) |
PF04616(Glyco_hydro_43) | 4 | HIS A 334SER A 72ARG A 122THR A 317 | NoneGOL A 403 ( 4.5A)NoneGOL A 403 (-4.0A) | 1.25A | 3okxA-5gllA:undetectable | 3okxA-5gllA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ihr | PROBABLEBETA-GALACTOSIDASE A (Aspergillusniger) |
PF01301(Glyco_hydro_35)PF10435(BetaGal_dom2)PF13363(BetaGal_dom3)PF13364(BetaGal_dom4_5) | 4 | HIS A 432SER A 433ASP A 410THR A 441 | None | 1.18A | 3okxA-5ihrA:undetectable | 3okxA-5ihrA:10.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5njf | METALLOPROTEASE PMBA (Escherichiacoli) |
PF01523(PmbA_TldD) | 4 | HIS B 187SER B 214ASP B 125THR B 185 | None | 1.38A | 3okxA-5njfB:undetectable | 3okxA-5njfB:18.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5u70 | POTASSIUM CHANNELSUBFAMILY T MEMBER 1 (Gallus gallus) |
PF03493(BK_channel_a)PF07885(Ion_trans_2) | 4 | SER A 516ARG A 923ASP A 367THR A 510 | None | 1.39A | 3okxA-5u70A:undetectable | 3okxA-5u70A:9.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xfa | NAD-REDUCINGHYDROGENASE (Hydrogenophilusthermoluteolus) |
PF01257(2Fe-2S_thioredx)PF01512(Complex1_51K)PF10589(NADH_4Fe-4S) | 4 | HIS A 66ARG A 128ASP A 73THR A 107 | None | 1.46A | 3okxA-5xfaA:undetectable | 3okxA-5xfaA:16.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yj6 | DOCKERIN TYPE IREPEAT-CONTAININGPROTEIN (Ruminiclostridiumthermocellum) |
no annotation | 4 | HIS A 183SER A 86ASP A 297THR A 251 | NoneNoneNone33O A 801 ( 3.9A) | 1.49A | 3okxA-5yj6A:undetectable | 3okxA-5yj6A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfu | SPIKE PROTEIN (CoronavirusHKU15) |
no annotation | 4 | HIS A 275SER A 273ASP A 244THR A 258 | None | 1.36A | 3okxA-6bfuA:undetectable | 3okxA-6bfuA:11.38 |