SIMILAR PATTERNS OF AMINO ACIDS FOR 3OKX_A_SAMA201_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 TYR A 192
LEU A 128
PRO A 127
GLY A 141
LEU A  55
 None
 1.31A 3okxA-1dcuA:
0.0		 3okxA-1dcuA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e33 ARYLSULFATASE A

(Homo sapiens) 		PF00884
(Sulfatase)
PF14707
(Sulfatase_C) 		5 LEU P  49
CYH P  38
HIS P  41
LEU P  31
GLY P  32
 None
 1.29A 3okxA-1e33P:
0.0		 3okxA-1e33P:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fq3 GRANZYME B

(Homo sapiens) 		PF00089
(Trypsin) 		5 TYR A 215
LEU A 171
ARG A 172
GLY A 216
SER A 214
 None
 1.34A 3okxA-1fq3A:
0.5		 3okxA-1fq3A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hcy ARTHROPODAN
HEMOCYANIN

(Panulirus
interruptus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 LEU A  86
TYR A  46
GLY A  50
THR A  43
LEU A  90
 None
 1.37A 3okxA-1hcyA:
0.1		 3okxA-1hcyA:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7o 4-HYDROXYPHENYLACETA
TE DEGRADATION
BIFUNCTIONAL
ISOMERASE/DECARBOXYL
ASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		5 LEU A 375
TYR A 232
LEU A 368
THR A 364
LEU A 228
 None
 1.32A 3okxA-1i7oA:
0.0		 3okxA-1i7oA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwl OUTER-MEMBRANE
LIPOPROTEINS CARRIER
PROTEIN

(Escherichia
coli) 		PF03548
(LolA) 		5 LEU A   6
LEU A  92
GLY A  86
THR A  85
LEU A  10
 None
 0.98A 3okxA-1iwlA:
0.0		 3okxA-1iwlA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 TYR A  74
LEU A  78
GLY A 250
SER A  97
LEU A  55
 None
 1.34A 3okxA-1jqiA:
0.0		 3okxA-1jqiA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7j D-AMINOACYLASE

(Alcaligenes
faecalis) 		PF07969
(Amidohydro_3) 		5 PRO A 194
GLY A 189
THR A 188
SER A 187
LEU A 114
 None
 0.96A 3okxA-1m7jA:
undetectable		 3okxA-1m7jA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o7d LYSOSOMAL
ALPHA-MANNOSIDASE

(Bos taurus) 		PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 LEU C 465
HIS C 445
GLY C 451
THR C 452
SER C 453
 None
 1.36A 3okxA-1o7dC:
0.0		 3okxA-1o7dC:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r9j TRANSKETOLASE

(Leishmania
mexicana) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 LEU A 547
ARG A 571
PRO A 600
GLY A 649
THR A 648
 None
 1.38A 3okxA-1r9jA:
undetectable		 3okxA-1r9jA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1spi FRUCTOSE
1,6-BISPHOSPHATASE

(Spinacia
oleracea) 		PF00316
(FBPase) 		5 TYR A 193
LEU A 130
PRO A 129
GLY A 143
LEU A  57
 None
 1.09A 3okxA-1spiA:
undetectable		 3okxA-1spiA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tjr BX1

(Zea mays) 		PF00290
(Trp_syntA) 		5 LEU A 233
TYR A 107
LEU A 184
GLY A 136
THR A 109
 None
 1.27A 3okxA-1tjrA:
undetectable		 3okxA-1tjrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		5 LEU A  93
TYR A 248
GLY A 168
THR A 169
LEU A 250
 None
 1.33A 3okxA-1w5dA:
undetectable		 3okxA-1w5dA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7n AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY A MEMBER 1

(Homo sapiens) 		PF00595
(PDZ) 		5 LEU A  75
HIS A  53
ARG A  19
GLY A  48
LEU A  26
 None
 1.30A 3okxA-1y7nA:
undetectable		 3okxA-1y7nA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a98 INOSITOL
1,4,5-TRISPHOSPHATE
3-KINASE C

(Homo sapiens) 		PF03770
(IPK) 		5 LEU A 599
ARG A 603
GLY A 551
THR A 547
SER A 546
 None
 1.37A 3okxA-2a98A:
undetectable		 3okxA-2a98A:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		5 LEU A 108
LEU A  31
ARG A  33
GLY A  17
SER A 270
 None
 1.16A 3okxA-2cuyA:
undetectable		 3okxA-2cuyA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 289
HIS A 267
LEU A 276
GLY A 320
THR A 319
 None
 1.31A 3okxA-2d5lA:
undetectable		 3okxA-2d5lA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ehq 1-PYRROLINE-5-CARBOX
YLATE DEHYDROGENASE

(Thermus
thermophilus) 		PF00171
(Aldedh) 		5 TYR A 145
LEU A 503
ARG A 151
GLY A 196
LEU A 500
 None
None
MPD  A1533 (-4.2A)
None
MPD  A1533 ( 3.7A)
 1.33A 3okxA-2ehqA:
undetectable		 3okxA-2ehqA:
13.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j1n OUTER MEMBRANE
PROTEIN C

(Escherichia
coli) 		PF00267
(Porin_1) 		5 LEU A 285
ARG A 287
GLY A 282
SER A 280
LEU A 250
 None
 0.92A 3okxA-2j1nA:
undetectable		 3okxA-2j1nA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbr P-HYDROXYPHENYLACETA
TE HYDROXYLASE C2
OXYGENASE COMPONENT

(Acinetobacter
baumannii) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		5 CYH A 361
LEU A 324
ARG A 322
THR A 352
LEU A 275
 None
 1.23A 3okxA-2jbrA:
undetectable		 3okxA-2jbrA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgg RNA-DIRECTED RNA
POLYMERASE

(Infectious
bursal disease
virus) 		PF04197
(Birna_RdRp) 		5 LEU A 249
GLY A 268
THR A 266
SER A 256
LEU A 346
 None
 1.21A 3okxA-2pggA:
undetectable		 3okxA-2pggA:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		5 LEU A 455
ARG A 456
GLY A 492
CYH A 691
LEU A 457
 None
 1.35A 3okxA-2r05A:
undetectable		 3okxA-2r05A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rch CYTOCHROME P450 74A

(Arabidopsis
thaliana) 		PF00067
(p450) 		5 LEU A 285
ARG A 284
GLY A 215
THR A 216
LEU A 235
 None
 1.29A 3okxA-2rchA:
undetectable		 3okxA-2rchA:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdj HOMOSERINE
O-SUCCINYLTRANSFERAS
E

(Bacillus cereus) 		PF04204
(HTS) 		5 HIS A 140
LEU A 208
ARG A 203
GLY A 224
LEU A 210
 None
 1.25A 3okxA-2vdjA:
undetectable		 3okxA-2vdjA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ws9 P1

(Equine rhinitis
A virus) 		no annotation 5 LEU 1  72
HIS 1 191
TYR 1 160
THR 1 161
SER 1 162
 None
 1.19A 3okxA-2ws91:
undetectable		 3okxA-2ws91:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv7 CG10997-PA

(Drosophila
melanogaster) 		no annotation 5 LEU A  52
CYH A 176
GLY A 168
CYH A 172
LEU A 114
 None
 1.37A 3okxA-2yv7A:
undetectable		 3okxA-2yv7A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		5 LEU A 113
CYH A  47
HIS A 175
LEU A 150
GLY A 120
 None
 1.31A 3okxA-2yvaA:
undetectable		 3okxA-2yvaA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zoa PHOSPHOHYDROLASE

(Klebsiella
aerogenes) 		PF00149
(Metallophos) 		5 LEU A 162
HIS A 156
GLY A 129
SER A 121
LEU A 160
 None
FE2  A 276 (-3.6A)
None
None
None
 1.32A 3okxA-2zoaA:
undetectable		 3okxA-2zoaA:
23.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b0b CENTROMERE PROTEIN S
CENTROMERE PROTEIN X

(Gallus gallus;
Gallus gallus) 		no annotation
PF09415
(CENP-X) 		5 LEU B  12
LEU C  16
ARG C  15
THR B  51
SER B  48
 None
 1.27A 3okxA-3b0bB:
undetectable		 3okxA-3b0bB:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhn THIJ/PFPI DOMAIN
PROTEIN

(Shewanella
loihica) 		PF01965
(DJ-1_PfpI) 		5 LEU A 154
THR A  68
SER A  69
CYH A 151
LEU A 152
 None
 1.37A 3okxA-3bhnA:
undetectable		 3okxA-3bhnA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cuc PROTEIN OF UNKNOWN
FUNCTION WITH A FIC
DOMAIN

(Bacteroides
thetaiotaomicron) 		PF02661
(Fic) 		5 LEU A 210
TYR A 260
LEU A 261
CYH A 264
LEU A 265
 None
 1.39A 3okxA-3cucA:
undetectable		 3okxA-3cucA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d9h CDNA FLJ77766,
HIGHLY SIMILAR TO
HOMO SAPIENS ANKYRIN
REPEAT AND SOCS
BOX-CONTAINING 9
(ASB9), TRANSCRIPT
VARIANT 2, MRNA

(Homo sapiens) 		PF12796
(Ank_2) 		5 LEU A  89
PRO A 105
SER A 112
CYH A 117
LEU A 120
 None
 1.37A 3okxA-3d9hA:
undetectable		 3okxA-3d9hA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 LEU A 196
CYH A 172
TYR A 179
LEU A 223
LEU A 181
 None
 1.17A 3okxA-3e02A:
undetectable		 3okxA-3e02A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e02 UNCHARACTERIZED
PROTEIN DUF849

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 LEU A 196
HIS A 215
TYR A 179
LEU A 223
LEU A 181
 None
 1.28A 3okxA-3e02A:
undetectable		 3okxA-3e02A:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euo TYPE III PENTAKETIDE
SYNTHASE

(Neurospora
crassa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 HIS A 305
LEU A 250
ARG A 266
SER A 153
LEU A 270
 None
 1.22A 3okxA-3euoA:
undetectable		 3okxA-3euoA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ht4 ALUMINUM RESISTANCE
PROTEIN

(Bacillus cereus) 		PF06838
(Met_gamma_lyase) 		5 LEU A 260
TYR A 245
ARG A  86
GLY A 229
LEU A  84
 None
 1.30A 3okxA-3ht4A:
undetectable		 3okxA-3ht4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ix6 THYMIDYLATE SYNTHASE

(Brucella
melitensis) 		PF00303
(Thymidylat_synt) 		5 LEU A   8
HIS A 201
LEU A  45
PRO A 175
LEU A   5
 None
 1.37A 3okxA-3ix6A:
undetectable		 3okxA-3ix6A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkv UNCHARACTERIZED
CONSERVED DOMAIN
PROTEIN

(Vibrio cholerae) 		PF04392
(ABC_sub_bind) 		5 LEU A 176
GLY A 259
THR A 247
SER A 248
LEU A 219
 None
 1.39A 3okxA-3lkvA:
undetectable		 3okxA-3lkvA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mw8 UROPORPHYRINOGEN-III
SYNTHASE

(Shewanella
amazonensis) 		PF02602
(HEM4) 		5 LEU A 158
CYH A 155
THR A 178
SER A 179
LEU A 189
 None
None
None
EDO  A 301 (-3.7A)
None
 1.13A 3okxA-3mw8A:
undetectable		 3okxA-3mw8A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n9y ADRENODOXIN

(Homo sapiens) 		PF00111
(Fer2) 		5 LEU C  30
GLY C  48
THR C  49
CYH C  55
LEU C  57
 None
FES  C 150 (-4.0A)
None
FES  C 150 (-2.1A)
None
 1.29A 3okxA-3n9yC:
undetectable		 3okxA-3n9yC:
19.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3naw SECRETED EFFECTOR
PROTEIN

(Escherichia
coli) 		PF00805
(Pentapeptide)
PF13979
(SopA_C)
PF13981
(SopA) 		5 LEU A 744
GLY A 703
THR A 704
CYH A 753
LEU A 757
 None
 0.85A 3okxA-3nawA:
undetectable		 3okxA-3nawA:
15.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		12 LEU A  37
CYH A  40
HIS A  43
TYR A  76
LEU A  78
ARG A  80
PRO A 105
GLY A 112
THR A 113
SER A 114
CYH A 133
LEU A 134
 SAM  A 201 (-4.5A)
SAM  A 201 (-4.0A)
SAM  A 201 (-4.2A)
None
SAM  A 201 (-4.1A)
None
SAM  A 201 (-3.8A)
SAM  A 201 (-3.6A)
SAM  A 201 (-4.2A)
SAM  A 201 ( 3.9A)
None
SAM  A 201 (-4.2A)
 0.00A 3okxA-3okxA:
27.3		 3okxA-3okxA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E

(Proteus
mirabilis) 		PF00582
(Usp) 		5 LEU A 233
HIS A 169
LEU A 176
GLY A 270
LEU A 195
 None
 1.33A 3okxA-3olqA:
undetectable		 3okxA-3olqA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om5 LEVANSUCRASE

(Bacillus
megaterium) 		PF02435
(Glyco_hydro_68) 		5 LEU A 323
LEU A 387
GLY A 405
THR A 404
LEU A 365
 None
 1.33A 3okxA-3om5A:
undetectable		 3okxA-3om5A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 LEU A 196
GLY A 146
THR A 147
SER A 148
LEU A 304
 None
None
BAU  A 400 (-4.5A)
None
None
 1.31A 3okxA-3p0fA:
undetectable		 3okxA-3p0fA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppc 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Candida
albicans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 596
ARG A 597
GLY A 569
THR A 572
LEU A 594
 None
 1.37A 3okxA-3ppcA:
undetectable		 3okxA-3ppcA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qty PHOSPHORIBOSYLAMINOI
MIDAZOLE (AIR)
SYNTHETASE

(Francisella
tularensis) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 LEU A 265
ARG A 263
PRO A 266
GLY A 270
THR A 339
 None
 1.23A 3okxA-3qtyA:
undetectable		 3okxA-3qtyA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 LEU A 191
CYH A 195
LEU A  14
GLY A  24
THR A  25
 None
 1.25A 3okxA-3rd7A:
undetectable		 3okxA-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd7 ACYL-COA
THIOESTERASE

(Mycobacterium
avium) 		PF13622
(4HBT_3) 		5 LEU A 191
CYH A 195
TYR A  75
LEU A  14
GLY A  24
 None
 1.32A 3okxA-3rd7A:
undetectable		 3okxA-3rd7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 LEU A 106
HIS A  14
GLY A 177
SER A  41
LEU A  84
 None
 0.99A 3okxA-3rksA:
undetectable		 3okxA-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rks HYDROXYNITRILASE

(Manihot
esculenta) 		PF00561
(Abhydrolase_1) 		5 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
 1.37A 3okxA-3rksA:
undetectable		 3okxA-3rksA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sma FRBF

(Streptomyces
rubellomurinus) 		PF02522
(Antibiotic_NAT) 		5 LEU A 181
ARG A 250
THR A 190
SER A 191
LEU A 242
 None
None
ACO  A 300 (-3.7A)
None
None
 1.34A 3okxA-3smaA:
undetectable		 3okxA-3smaA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stt METHYLKETONE
SYNTHASE I

(Solanum
habrochaites) 		PF12697
(Abhydrolase_6) 		5 LEU A 113
HIS A  21
TYR A  64
SER A  48
LEU A  91
 None
 1.24A 3okxA-3sttA:
undetectable		 3okxA-3sttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trj PHOSPHOHEPTOSE
ISOMERASE

(Francisella
tularensis) 		PF13580
(SIS_2) 		5 LEU A 115
CYH A  49
HIS A 177
LEU A 152
GLY A 122
 None
 1.36A 3okxA-3trjA:
undetectable		 3okxA-3trjA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujk PROTEIN PHOSPHATASE
2C 77

(Arabidopsis
thaliana) 		PF00481
(PP2C) 		5 LEU A 182
TYR A 164
GLY A 162
SER A 234
CYH A 176
 None
 1.32A 3okxA-3ujkA:
undetectable		 3okxA-3ujkA:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		5 LEU A 104
LEU A 101
ARG A  91
GLY A 251
LEU A 114
 None
 1.21A 3okxA-3v7nA:
undetectable		 3okxA-3v7nA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vrb IRON-SULFUR SUBUNIT
OF SUCCINATE
DEHYDROGENASE

(Ascaris suum) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 LEU B 266
TYR B 202
LEU B 208
GLY B 204
SER B 194
 None
None
None
None
F3S  B 303 (-4.4A)
 1.34A 3okxA-3vrbB:
undetectable		 3okxA-3vrbB:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 LEU C 253
TYR C 133
GLY C 208
THR C 207
SER C 206
 None
None
FAD  C1283 (-3.6A)
FAD  C1283 (-4.6A)
None
 1.26A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ci0 F420-REDUCING
HYDROGENASE, SUBUNIT
BETA

(Methanothermobacter
marburgensis) 		PF04422
(FrhB_FdhB_N)
PF04432
(FrhB_FdhB_C) 		5 LEU C 253
TYR C 133
THR C 207
SER C 206
LEU C 257
 None
None
FAD  C1283 (-4.6A)
None
None
 1.38A 3okxA-4ci0C:
undetectable		 3okxA-4ci0C:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4czp EXTRALONG MANGANESE
PEROXIDASE

(Gelatoporia
subvermispora) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		5 LEU A 228
PRO A 227
GLY A 229
THR A 231
SER A 232
 None
 1.31A 3okxA-4czpA:
undetectable		 3okxA-4czpA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d74 PROTEIN-TYROSINE-PHO
SPHATASE AMSI

(Erwinia
amylovora) 		PF01451
(LMWPc) 		5 LEU A  68
HIS A  63
GLY A  19
THR A  18
CYH A   9
 None
None
None
None
SO4  A1145 (-3.2A)
 1.35A 3okxA-4d74A:
undetectable		 3okxA-4d74A:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gh4 CAPSID PROTEIN VP1
CAPSID PROTEIN VP2

(Foot-and-mouth
disease virus;
Foot-and-mouth
disease virus) 		PF00073
(Rhv)
PF00073
(Rhv) 		5 LEU B 163
TYR A 130
PRO B 176
GLY A 132
THR A 133
 None
 1.04A 3okxA-4gh4B:
undetectable		 3okxA-4gh4B:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE

(Stenotrophomonas
maltophilia) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		5 LEU A 117
PRO A 362
GLY A 364
THR A 365
CYH A 374
 None
None
None
15P  A 504 (-3.9A)
None
 0.89A 3okxA-4grhA:
undetectable		 3okxA-4grhA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grv NEUROTENSIN RECEPTOR
TYPE 1, LYSOZYME
CHIMERA

(Rattus
norvegicus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 LEU A 119
CYH A 152
LEU A 117
SER A 361
LEU A 115
 None
 1.21A 3okxA-4grvA:
undetectable		 3okxA-4grvA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4it1 PUTATIVE GLUCARATE
DEHYDRATASE

(Pseudomonas
fluorescens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  73
HIS A 294
GLY A  46
SER A  48
LEU A  76
 None
 1.26A 3okxA-4it1A:
undetectable		 3okxA-4it1A:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lan URACIL-5-CARBOXYLATE
DECARBOXYLASE

(Cordyceps
militaris) 		PF04909
(Amidohydro_2) 		5 LEU A 104
HIS A 197
TYR A  16
LEU A  24
PRO A  31
 None
 1.03A 3okxA-4lanA:
undetectable		 3okxA-4lanA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4or1 INVASIN HOMOLOG
AAFB, MAJOR FIMBRIAL
SUBUNIT OF
AGGREGATIVE
ADHERENCE FIMBRIA II
AAFA CHIMERIC
CONSTRUCT

(Escherichia
coli) 		PF05775
(AfaD) 		5 LEU A   5
HIS A  37
TYR A  52
LEU A  68
GLY A  50
 None
 1.36A 3okxA-4or1A:
undetectable		 3okxA-4or1A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p1b TOLUENE-4-MONOOXYGEN
ASE SYSTEM
FERREDOXIN SUBUNIT

(Pseudomonas
mendocina) 		PF00355
(Rieske) 		5 LEU H  86
HIS H  36
TYR H  57
GLY H  60
LEU H  52
 None
 1.29A 3okxA-4p1bH:
undetectable		 3okxA-4p1bH:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		5 LEU A 156
HIS A 274
TYR A  90
SER A 278
LEU A  77
 None
 1.20A 3okxA-4p9nA:
undetectable		 3okxA-4p9nA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 5 LEU A 144
TYR A 423
ARG A 124
GLY A 320
THR A 319
 None
 1.27A 3okxA-4po6A:
undetectable		 3okxA-4po6A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 LEU A 327
TYR A 339
GLY A 288
THR A 289
SER A 290
 None
None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.6A)
 0.96A 3okxA-4rg1A:
undetectable		 3okxA-4rg1A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2d FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 2

(Homo sapiens) 		PF01463
(LRRCT)
PF13855
(LRR_8) 		5 LEU A 281
LEU A 275
GLY A 251
THR A 252
LEU A 302
 None
 1.10A 3okxA-4v2dA:
undetectable		 3okxA-4v2dA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x28 ACYL-COA
DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  77
LEU A 299
PRO A 254
GLY A 330
THR A 331
 None
 1.37A 3okxA-4x28A:
undetectable		 3okxA-4x28A:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 5 LEU B 160
HIS B 233
LEU B 184
SER B 222
LEU B 169
 None
 1.31A 3okxA-4xeyB:
undetectable		 3okxA-4xeyB:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztx COBALAMIN-INDEPENDEN
T METHIONINE
SYNTHASE

(Neurospora
crassa) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		5 LEU A 591
ARG A 592
GLY A 564
THR A 567
LEU A 638
 None
 1.25A 3okxA-4ztxA:
undetectable		 3okxA-4ztxA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnc HEME BINDING PROTEIN
MSMEG_6519

(Mycolicibacterium
smegmatis) 		PF10615
(DUF2470)
PF13883
(Pyrid_oxidase_2) 		5 LEU A 191
CYH A 217
LEU A 259
GLY A 241
LEU A 199
 None
 1.35A 3okxA-5bncA:
undetectable		 3okxA-5bncA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 LEU A  30
HIS A 244
LEU A  68
PRO A 218
LEU A  27
 None
 1.33A 3okxA-5by6A:
undetectable		 3okxA-5by6A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 LEU A 745
LEU A 697
PRO A 695
GLY A 698
SER A 713
 HEC  A 906 (-4.8A)
None
None
None
None
 1.38A 3okxA-5c2vA:
undetectable		 3okxA-5c2vA:
13.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cb0 UNIVERSAL STRESS
PROTEIN E

(Escherichia
coli) 		PF00582
(Usp) 		5 LEU A 232
HIS A 169
LEU A 176
GLY A 269
LEU A 194
 None
 1.37A 3okxA-5cb0A:
undetectable		 3okxA-5cb0A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6n ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 TYR A 186
LEU A 184
GLY A 196
THR A 195
CYH A 126
 None
 1.18A 3okxA-5d6nA:
undetectable		 3okxA-5d6nA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt9 ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Vibrio cholerae) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		5 LEU A 285
CYH A 282
GLY A  70
THR A  71
LEU A  25
 None
 1.38A 3okxA-5dt9A:
undetectable		 3okxA-5dt9A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 136
LEU A 159
ARG A  73
SER A  63
LEU A 117
 None
 1.32A 3okxA-5dzqA:
undetectable		 3okxA-5dzqA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ey8 ACYL-COA SYNTHASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding) 		5 TYR A 186
LEU A 184
GLY A 196
THR A 195
CYH A 126
 None
 1.28A 3okxA-5ey8A:
undetectable		 3okxA-5ey8A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fdn PHOSPHOENOLPYRUVATE
CARBOXYLASE 3

(Arabidopsis
thaliana) 		PF00311
(PEPcase) 		5 LEU A 521
ARG A 301
GLY A 287
SER A 283
LEU A 305
 None
 1.38A 3okxA-5fdnA:
undetectable		 3okxA-5fdnA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5giu PROLINE DIPEPTIDASE

(Deinococcus
radiodurans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N) 		5 LEU A 283
PRO A 315
GLY A 284
THR A 312
LEU A 265
 None
None
None
PO4  A 401 ( 4.9A)
None
 1.39A 3okxA-5giuA:
undetectable		 3okxA-5giuA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B

(Homo sapiens) 		no annotation 5 LEU A 836
ARG A 834
GLY A 847
THR A 848
SER A 849
 None
IHP  A1201 (-3.7A)
None
None
None
 1.06A 3okxA-5hdtA:
undetectable		 3okxA-5hdtA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lf9 NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 22

(Homo sapiens) 		no annotation 5 LEU A 197
CYH A 192
PRO A 153
GLY A 124
LEU A 202
 None
 1.36A 3okxA-5lf9A:
undetectable		 3okxA-5lf9A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m86 TA1207

(Thermoplasma
acidophilum) 		no annotation 5 TYR A 273
LEU A  41
PRO A  42
SER A 264
LEU A 275
 None
None
None
None
GOL  A 403 ( 4.6A)
 1.24A 3okxA-5m86A:
undetectable		 3okxA-5m86A:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nla PUTATIVE
TRANSCRIPTIONAL
REGULATOR
TRANSCRIPTION
REGULATOR PROTEIN

(Sinorhizobium
meliloti) 		PF12833
(HTH_18)
PF14525
(AraC_binding_2) 		5 LEU A 155
TYR A 109
GLY A 161
SER A 134
LEU A  70
 None
 1.39A 3okxA-5nlaA:
undetectable		 3okxA-5nlaA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 LEU A 106
HIS A  14
GLY A 176
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 0.99A 3okxA-5tdxA:
undetectable		 3okxA-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdx ANCESTRAL
HYDROXYNITRILE LYASE
1

(synthetic
construct) 		no annotation 5 LEU A 106
HIS A  14
TYR A  57
SER A  41
LEU A  84
 None
GOL  A 300 ( 4.6A)
None
None
None
 1.26A 3okxA-5tdxA:
undetectable		 3okxA-5tdxA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txe ATXE2

(Asticcacaulis
excentricus) 		PF00326
(Peptidase_S9) 		5 LEU A  43
ARG A  45
PRO A 456
GLY A 446
LEU A 647
 None
 1.33A 3okxA-5txeA:
undetectable		 3okxA-5txeA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uu6 NADPH-FLAVIN
OXIDOREDUCTASE

(Vibrio
parahaemolyticus) 		PF00881
(Nitroreductase) 		5 LEU A  31
LEU A 157
ARG A  50
GLY A 126
LEU A  27
 None
 1.33A 3okxA-5uu6A:
undetectable		 3okxA-5uu6A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm1 XYLULOKINASE

(Brucella ovis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 178
HIS A 281
GLY A 232
SER A 207
LEU A 203
 None
 1.39A 3okxA-5vm1A:
undetectable		 3okxA-5vm1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		5 LEU A 965
LEU A 944
GLY A 976
THR A 977
SER A 978
 None
 1.17A 3okxA-5wqwA:
undetectable		 3okxA-5wqwA:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Komagataella
phaffii) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		5 LEU B 281
HIS B 356
THR B 244
SER B 243
LEU B 349
 None
 1.16A 3okxA-5xogB:
0.5		 3okxA-5xogB:
9.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 LEU A1518
LEU A1521
ARG A1508
GLY A1532
THR A1496
 None
None
None
None
SO4  A1704 (-2.6A)
 1.33A 3okxA-5xyaA:
undetectable		 3okxA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ckc METHYLOSOME PROTEIN
50

(Homo sapiens) 		no annotation 5 LEU B 287
LEU B 261
GLY B 260
THR B 259
SER B 275
 None
 1.26A 3okxA-6ckcB:
undetectable		 3okxA-6ckcB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eo5 PPBBE-LIKE 1 D396N

(Physcomitrella
patens) 		no annotation 5 LEU A 118
HIS A 111
LEU A  68
ARG A  67
THR A 357
 None
FAD  A 601 (-2.6A)
None
None
None
 1.14A 3okxA-6eo5A:
undetectable		 3okxA-6eo5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoj POLYADENYLATION
FACTOR SUBUNIT
2,POLYADENYLATION
FACTOR SUBUNIT 2

(Saccharomyces
cerevisiae) 		no annotation 5 LEU D 233
PRO D 248
GLY D 251
CYH D 253
LEU D 245
 None
 1.37A 3okxA-6eojD:
undetectable		 3okxA-6eojD:
15.73