SIMILAR PATTERNS OF AMINO ACIDS FOR 3OI8_A_ADNA2_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bg6 | N-(1-D-CARBOXYLETHYL)-L-NORVALINEDEHYDROGENASE (Arthrobactersp. 1C) |
PF02317(Octopine_DH)PF02558(ApbA) | 4 | HIS A 17PRO A 62LEU A 65ASP A 34 | None | 1.10A | 3oi8A-1bg6A:undetectable | 3oi8A-1bg6A:16.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ded | CYCLODEXTRINGLUCANOTRANSFERASE (Bacillus sp.1011) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 4 | HIS A 98PRO A 143LEU A 197ASP A 229 | QPS A1001 ( 2.9A)NoneQPS A1001 (-3.7A)QPS A1001 (-2.7A) | 1.26A | 3oi8A-1dedA:undetectable | 3oi8A-1dedA:11.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e6z | CHITINASE B (Serratiamarcescens) |
PF00704(Glyco_hydro_18) | 4 | ILE A 183PRO A 205LEU A 206ASP A 140 | None | 1.28A | 3oi8A-1e6zA:undetectable | 3oi8A-1e6zA:12.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jmy | BILE-SALT-ACTIVATEDLIPASE (Homo sapiens) |
PF00135(COesterase) | 4 | ILE A 301HIS A 522PRO A 396LEU A 224 | None | 1.29A | 3oi8A-1jmyA:undetectable | 3oi8A-1jmyA:15.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0g | P-AMINOBENZOATESYNTHASE COMPONENT I (Escherichiacoli) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 4 | ILE A 144ASN A 97PRO A 6LEU A 155 | None | 1.12A | 3oi8A-1k0gA:undetectable | 3oi8A-1k0gA:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1kcl | CYCLODEXTRINGLYCOSYLTRANSFERASE (Bacilluscirculans) |
PF00128(Alpha-amylase)PF00686(CBM_20)PF01833(TIG)PF02806(Alpha-amylase_C) | 4 | HIS A 98PRO A 143LEU A 197ASP A 229 | BGC A1696 (-4.1A)NoneBGC A1696 (-4.8A)GLC A1695 (-3.2A) | 1.28A | 3oi8A-1kclA:undetectable | 3oi8A-1kclA:11.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ow1 | SMART/HDAC1ASSOCIATED REPRESSORPROTEIN (Homo sapiens) |
PF07744(SPOC) | 4 | ILE A3600HIS A3656PRO A3580LEU A3595 | None | 0.97A | 3oi8A-1ow1A:undetectable | 3oi8A-1ow1A:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1spi | FRUCTOSE1,6-BISPHOSPHATASE (Spinaciaoleracea) |
PF00316(FBPase) | 4 | ILE A 328PRO A 333LEU A 303ASP A 323 | None | 1.26A | 3oi8A-1spiA:undetectable | 3oi8A-1spiA:18.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1unf | IRON SUPEROXIDEDISMUTASE (Vignaunguiculata) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 4 | ILE X 73ASN X 94PRO X 190LEU X 183 | None | 1.22A | 3oi8A-1unfX:undetectable | 3oi8A-1unfX:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1v02 | DHURRINASE (Sorghum bicolor) |
PF00232(Glyco_hydro_1) | 4 | ILE A 326HIS A 236PRO A 190LEU A 258 | None | 1.03A | 3oi8A-1v02A:undetectable | 3oi8A-1v02A:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ae0 | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE A (Escherichiacoli) |
PF03562(MltA)PF06725(3D) | 4 | ILE X 136ASN X 184PRO X 124LEU X 141 | None | 1.12A | 3oi8A-2ae0X:undetectable | 3oi8A-2ae0X:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2efe | SIMILARITY TOVACUOLAR PROTEINSORTING-ASSOCIATEDPROTEIN VPS9 (Arabidopsisthaliana) |
PF02204(VPS9) | 4 | ILE A 159ASN A 206PRO A 200LEU A 143 | None | 1.30A | 3oi8A-2efeA:undetectable | 3oi8A-2efeA:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eyr | NKT12 (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 4 | ILE B 13PRO B 8LEU B 11ASP B 224 | None | 1.26A | 3oi8A-2eyrB:undetectable | 3oi8A-2eyrB:17.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fpr | HISTIDINEBIOSYNTHESISBIFUNCTIONAL PROTEINHISB (Escherichiacoli) |
PF08645(PNK3P) | 4 | ILE A 16HIS A 74LEU A 31ASP A 12 | None | 1.18A | 3oi8A-2fprA:undetectable | 3oi8A-2fprA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g5d | GNA33 (Neisseriagonorrhoeae) |
PF03562(MltA)PF06725(3D) | 4 | ILE A 235ASN A 283PRO A 163LEU A 240 | None | 1.16A | 3oi8A-2g5dA:undetectable | 3oi8A-2g5dA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gd2 | PROBABLEALPHA-METHYLACYL-COARACEMASE MCR (Mycobacteriumtuberculosis) |
PF02515(CoA_transf_3) | 4 | ILE A 131PRO A 147LEU A 137ASP A 127 | None | 1.20A | 3oi8A-2gd2A:undetectable | 3oi8A-2gd2A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gdf | LECTIN (Diocleaviolacea) |
PF00139(Lectin_legB) | 4 | ILE A 32HIS A 24LEU A 230ASP A 28 | None | 1.23A | 3oi8A-2gdfA:undetectable | 3oi8A-2gdfA:19.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hx5 | HYPOTHETICAL PROTEIN (Prochlorococcusmarinus) |
PF13279(4HBT_2) | 4 | ILE A 136HIS A 119PRO A 91LEU A 140 | None | 1.07A | 3oi8A-2hx5A:undetectable | 3oi8A-2hx5A:23.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3m | PROLYL-TRNASYNTHETASE (Enterococcusfaecalis) |
PF00587(tRNA-synt_2b)PF03129(HGTP_anticodon)PF04073(tRNA_edit) | 4 | ILE A 8HIS A 474PRO A 470LEU A 45 | None | 0.88A | 3oi8A-2j3mA:undetectable | 3oi8A-2j3mA:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jf7 | STRICTOSIDINE-O-BETA-D-GLUCOSIDASE (Rauvolfiaserpentina) |
PF00232(Glyco_hydro_1) | 4 | ILE A 340HIS A 249PRO A 208LEU A 272 | None | 0.99A | 3oi8A-2jf7A:undetectable | 3oi8A-2jf7A:14.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qjp | CYTOCHROME C1 (Rhodobactersphaeroides) |
PF02167(Cytochrom_C1) | 4 | ILE B 131HIS B 40PRO B 188LEU B 135 | HEM B 301 ( 4.3A)HEM B 301 (-3.2A)HEM B 301 ( 4.8A)HEM B 301 ( 4.7A) | 1.23A | 3oi8A-2qjpB:undetectable | 3oi8A-2qjpB:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rt5 | MSX2-INTERACTINGPROTEIN (Homo sapiens) |
PF07744(SPOC) | 4 | ILE A3600HIS A3656PRO A3580LEU A3595 | None | 1.11A | 3oi8A-2rt5A:undetectable | 3oi8A-2rt5A:22.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2waa | XYLAN ESTERASE,PUTATIVE, AXE2C (Cellvibriojaponicus) |
PF13472(Lipase_GDSL_2) | 4 | ASN A 262HIS A 221PRO A 226LEU A 136 | None | 0.97A | 3oi8A-2waaA:undetectable | 3oi8A-2waaA:17.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wnb | - (Sus scrofa) |
PF00777(Glyco_transf_29) | 4 | ILE A 120HIS A 251PRO A 211LEU A 217 | None | 1.18A | 3oi8A-2wnbA:undetectable | 3oi8A-2wnbA:22.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xnq | NUCLEARPOLYADENYLATEDRNA-BINDING PROTEIN3 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 4 | ILE A 334ASN A 389PRO A 338LEU A 337 | None | 1.26A | 3oi8A-2xnqA:undetectable | 3oi8A-2xnqA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yrf | METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE (Bacillussubtilis) |
PF01008(IF-2B) | 4 | ILE A 159ASN A 250LEU A 257ASP A 220 | None | 1.29A | 3oi8A-2yrfA:undetectable | 3oi8A-2yrfA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkt | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Pyrococcushorikoshii) |
PF01676(Metalloenzyme)PF10143(PhosphMutase) | 4 | ASN A 355HIS A 309PRO A 350ASP A 13 | None ZN A 415 (-3.5A)None ZN A 414 (-2.2A) | 0.91A | 3oi8A-2zktA:undetectable | 3oi8A-2zktA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zkt | 2,3-BISPHOSPHOGLYCERATE-INDEPENDENTPHOSPHOGLYCERATEMUTASE (Pyrococcushorikoshii) |
PF01676(Metalloenzyme)PF10143(PhosphMutase) | 4 | ASN A 355HIS A 309PRO A 350ASP A 346 | None ZN A 415 (-3.5A)None ZN A 414 (-2.8A) | 1.07A | 3oi8A-2zktA:undetectable | 3oi8A-2zktA:18.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bga | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ILE A 199ASN A 181LEU A 185ASP A 198 | None | 1.17A | 3oi8A-3bgaA:undetectable | 3oi8A-3bgaA:10.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clo | TRANSCRIPTIONALREGULATOR (Bacteroidesthetaiotaomicron) |
PF00196(GerE) | 4 | ASN A 152PRO A 149LEU A 22ASP A 49 | None | 1.23A | 3oi8A-3cloA:undetectable | 3oi8A-3cloA:20.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dec | BETA-GALACTOSIDASE (Bacteroidesthetaiotaomicron) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF02929(Bgal_small_N)PF16353(DUF4981) | 4 | ILE A 175ASN A 157LEU A 161ASP A 174 | None | 1.10A | 3oi8A-3decA:undetectable | 3oi8A-3decA:10.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dqv | CULLIN-5 (Homo sapiens) |
PF00888(Cullin)PF10557(Cullin_Nedd8) | 4 | ILE C1530ASN C1565HIS C1566LEU C1571 | None | 1.02A | 3oi8A-3dqvC:undetectable | 3oi8A-3dqvC:20.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dy5 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | ASN A 947HIS A 943LEU A 758ASP A 797 | FE2 A1099 (-2.8A)FE2 A1099 (-3.1A)NoneNone | 1.26A | 3oi8A-3dy5A:undetectable | 3oi8A-3dy5A:9.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fg4 | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
PF00305(Lipoxygenase)PF01477(PLAT) | 4 | ASN A 947HIS A 943LEU A 758ASP A 797 | FE2 A1500 (-3.7A)FE2 A1500 (-3.2A)NoneACD A2001 ( 4.5A) | 1.11A | 3oi8A-3fg4A:undetectable | 3oi8A-3fg4A:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3foa | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N) | 4 | ASN A 425PRO A 410LEU A 383ASP A 438 | None | 1.09A | 3oi8A-3foaA:undetectable | 3oi8A-3foaA:14.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hmj | FATTY ACID SYNTHASESUBUNIT ALPHA (Saccharomycescerevisiae) |
PF00109(ketoacyl-synt)PF01648(ACPS)PF02801(Ketoacyl-synt_C) | 4 | ILE A1573ASN A1570HIS A 454LEU A1625 | None | 1.13A | 3oi8A-3hmjA:undetectable | 3oi8A-3hmjA:6.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ijd | UNCHARACTERIZEDPROTEIN (Ruminiclostridiumthermocellum) |
PF02219(MTHFR) | 4 | ILE A 260ASN A 187PRO A 236LEU A 256 | None | 1.23A | 3oi8A-3ijdA:undetectable | 3oi8A-3ijdA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j2n | TAIL SHEATH PROTEINGP18 (Escherichiavirus T4) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N)PF17482(Phage_sheath_1C) | 4 | ASN U 425PRO U 410LEU U 383ASP U 438 | None | 1.09A | 3oi8A-3j2nU:undetectable | 3oi8A-3j2nU:12.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3jtf | MAGNESIUM AND COBALTEFFLUX PROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 4 | HIS A 109PRO A 113LEU A 185ASP A 190 | AMP A 1 (-3.5A)AMP A 1 (-4.7A)NoneAMP A 1 (-2.6A) | 0.57A | 3oi8A-3jtfA:18.8 | 3oi8A-3jtfA:44.79 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lfr | PUTATIVE METAL IONTRANSPORTER (Pseudomonassyringae groupgenomosp. 3) |
PF00571(CBS) | 4 | HIS A 94PRO A 98LEU A 173ASP A 178 | AMP A 1 (-3.4A)AMP A 1 (-4.9A)NoneAMP A 1 (-2.7A) | 0.40A | 3oi8A-3lfrA:20.8 | 3oi8A-3lfrA:42.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3lhh | CBS DOMAIN PROTEIN (Shewanellaoneidensis) |
PF00571(CBS) | 4 | HIS A 73PRO A 77LEU A 150ASP A 155 | AMP A 171 (-3.4A)AMP A 171 (-4.6A)NoneAMP A 171 (-2.6A) | 0.41A | 3oi8A-3lhhA:17.5 | 3oi8A-3lhhA:30.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mz2 | GLYCEROPHOSPHORYLDIESTERPHOSPHODIESTERASE (Parabacteroidesdistasonis) |
PF03009(GDPD) | 4 | ILE A 143ASN A 72PRO A 70LEU A 131 | None | 1.20A | 3oi8A-3mz2A:undetectable | 3oi8A-3mz2A:24.61 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3nqr | MAGNESIUM AND COBALTEFFLUX PROTEIN CORC (Salmonellaenterica) |
PF00571(CBS) | 5 | ILE A 74HIS A 100PRO A 104LEU A 178ASP A 183 | AMP A 1 (-4.2A)AMP A 1 (-3.4A)NoneNoneAMP A 1 (-2.4A) | 0.42A | 3oi8A-3nqrA:21.4 | 3oi8A-3nqrA:52.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ocm | PUTATIVE MEMBRANEPROTEIN (Bordetellaparapertussis) |
PF00571(CBS) | 4 | HIS A 365PRO A 369LEU A 441ASP A 446 | ADP A 470 ( 3.3A)NoneADP A 470 (-4.8A)ADP A 470 (-2.8A) | 0.75A | 3oi8A-3ocmA:6.1 | 3oi8A-3ocmA:31.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p27 | ELONGATION FACTOR 1ALPHA-LIKE PROTEIN (Saccharomycescerevisiae) |
PF00009(GTP_EFTU)PF03143(GTP_EFTU_D3) | 4 | ILE A 556HIS A 558PRO A 521LEU A 541 | None | 1.21A | 3oi8A-3p27A:undetectable | 3oi8A-3p27A:16.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pb9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE-LIKE PROTEIN (Homo sapiens) |
PF04389(Peptidase_M28) | 4 | HIS X 351PRO X 347LEU X 270ASP X 326 | ZN X 400 ( 3.2A)None1BN X 390 ( 4.7A)1BN X 390 ( 4.2A) | 1.10A | 3oi8A-3pb9X:undetectable | 3oi8A-3pb9X:17.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ptk | BETA-GLUCOSIDASEOS4BGLU12 (Oryza sativa) |
PF00232(Glyco_hydro_1) | 4 | ILE A 317HIS A 226PRO A 180LEU A 249 | None | 1.14A | 3oi8A-3ptkA:undetectable | 3oi8A-3ptkA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfs | NADPH--CYTOCHROMEP450 REDUCTASE (Homo sapiens) |
PF00175(NAD_binding_1)PF00667(FAD_binding_1) | 4 | ASN A 489HIS A 429PRO A 383ASP A 436 | None | 1.30A | 3oi8A-3qfsA:undetectable | 3oi8A-3qfsA:18.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk9 | MITOCHONDRIAL IMPORTINNER MEMBRANETRANSLOCASE SUBUNITTIM44 (Saccharomycescerevisiae) |
PF04280(Tim44) | 4 | ILE A 257ASN A 259PRO A 359LEU A 357 | None | 1.27A | 3oi8A-3qk9A:undetectable | 3oi8A-3qk9A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s1v | PROBABLETRANSALDOLASE (Thermoplasmaacidophilum) |
PF00923(TAL_FSA) | 4 | ASN A 170HIS A 173PRO A 188ASP A 138 | GOL A 224 (-3.7A)GOL A 224 (-4.1A)NoneNone | 1.27A | 3oi8A-3s1vA:undetectable | 3oi8A-3s1vA:21.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tov | GLYCOSYL TRANSFERASEFAMILY 9 (Veillonellaparvula) |
PF01075(Glyco_transf_9) | 4 | ILE A 274HIS A 135PRO A 24LEU A 157 | None | 1.07A | 3oi8A-3tovA:undetectable | 3oi8A-3tovA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wcs | ERYTHROAGGLUTININ (Phaseolusvulgaris) |
PF00139(Lectin_legB) | 4 | ILE A 168HIS A 160LEU A 127ASP A 164 | None MN A1002 (-3.3A)NoneNone | 1.25A | 3oi8A-3wcsA:undetectable | 3oi8A-3wcsA:20.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3whi | SUBTILISIN E (Bacillussubtilis) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 4 | ILE A 198PRO A 258LEU A 225ASP A 71 | None | 1.26A | 3oi8A-3whiA:undetectable | 3oi8A-3whiA:16.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aj9 | CATALASE-3 (Neurosporacrassa) |
PF00199(Catalase)PF06628(Catalase-rel) | 4 | ILE A 566PRO A 663LEU A 702ASP A 595 | None | 1.26A | 3oi8A-4aj9A:undetectable | 3oi8A-4aj9A:12.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4aov | ISOCITRATEDEHYDROGENASE [NADP] (Desulfotaleapsychrophila) |
PF00180(Iso_dh) | 4 | ILE A 387PRO A 23LEU A 24ASP A 391 | None | 1.19A | 3oi8A-4aovA:undetectable | 3oi8A-4aovA:17.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dia | 2-PYRONE-4,6-DICARBAXYLATE HYDROLASE (Sphingomonaspaucimobilis) |
PF04909(Amidohydro_2) | 4 | HIS A 251PRO A 16LEU A 62ASP A 29 | None | 1.18A | 3oi8A-4diaA:undetectable | 3oi8A-4diaA:20.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dvh | SUPEROXIDE DISMUTASE (Trypanosomacruzi) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 4 | ILE A 57ASN A 78PRO A 158LEU A 152 | None | 1.28A | 3oi8A-4dvhA:undetectable | 3oi8A-4dvhA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 4 | ASN B1463PRO B1381LEU B1458ASP B1683 | None | 1.11A | 3oi8A-4f92B:undetectable | 3oi8A-4f92B:7.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f9u | CG32412 (Drosophilamelanogaster) |
PF04389(Peptidase_M28) | 4 | HIS A 297PRO A 293LEU A 219ASP A 272 | ZN A 401 ( 3.1A)NoneNonePBD A 402 ( 4.3A) | 1.16A | 3oi8A-4f9uA:undetectable | 3oi8A-4f9uA:21.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fai | CG5976, ISOFORM B (Drosophilamelanogaster) |
PF04389(Peptidase_M28) | 4 | HIS A 318PRO A 314LEU A 229ASP A 293 | ZN A 401 ( 3.2A)NonePBD A 402 (-4.8A)PBD A 402 ( 4.1A) | 1.13A | 3oi8A-4faiA:undetectable | 3oi8A-4faiA:20.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4gic | HISTIDINOLDEHYDROGENASE (Methylococcuscapsulatus) |
PF00815(Histidinol_dh) | 4 | ILE A 348ASN A 350PRO A 331LEU A 334 | None | 1.06A | 3oi8A-4gicA:undetectable | 3oi8A-4gicA:19.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4hg0 | MAGNESIUM AND COBALTEFFLUX PROTEIN CORC (Escherichiacoli) |
PF00571(CBS)PF03471(CorC_HlyC) | 5 | ILE A 74HIS A 100PRO A 104LEU A 178ASP A 183 | AMP A 301 (-4.5A)AMP A 301 (-3.3A)AMP A 301 (-4.7A)NoneAMP A 301 (-3.3A) | 0.54A | 3oi8A-4hg0A:18.4 | 3oi8A-4hg0A:47.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hu8 | GH10 XYLANASE (Globitermesbrachycerastes) |
PF00331(Glyco_hydro_10)PF02368(Big_2) | 4 | ILE A 252HIS A 206LEU A 249ASP A 300 | None | 1.22A | 3oi8A-4hu8A:undetectable | 3oi8A-4hu8A:15.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jge | RED FLUORESCENTPROTEIN BLFP-R5 (Branchiostomalanceolatum) |
PF01353(GFP) | 4 | ILE A 11ASN A 56HIS A 103LEU A 9 | None | 1.21A | 3oi8A-4jgeA:undetectable | 3oi8A-4jgeA:19.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mh1 | SORBOSEDEHYDROGENASE (Ketogulonicigeniumvulgare) |
PF13360(PQQ_2) | 4 | ILE A 354HIS A 272PRO A 276ASP A 355 | None | 1.25A | 3oi8A-4mh1A:undetectable | 3oi8A-4mh1A:14.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4mhp | GLUTAMINYL CYCLASE,PUTATIVE (Ixodesscapularis) |
PF04389(Peptidase_M28) | 4 | HIS A 322PRO A 318LEU A 239ASP A 297 | None | 1.22A | 3oi8A-4mhpA:undetectable | 3oi8A-4mhpA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q5w | MATERNAL PROTEINTUDOR (Drosophilamelanogaster) |
PF00567(TUDOR) | 4 | ILE A2008PRO A2074LEU A2012ASP A2060 | None | 1.24A | 3oi8A-4q5wA:undetectable | 3oi8A-4q5wA:23.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uuy | VACUOLAR MEMBRANEPROTEIN PEP3 (Saccharomycescerevisiae) |
PF05131(Pep3_Vps18) | 4 | ILE A 164ASN A 143PRO A 184LEU A 169 | None | 1.19A | 3oi8A-4uuyA:undetectable | 3oi8A-4uuyA:23.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xdy | KETOL-ACIDREDUCTOISOMERASE (unculturedarchaeonGZfos26G2) |
PF01450(IlvC)PF07991(IlvN) | 4 | ILE A 83ASN A 115PRO A 123LEU A 108 | None | 1.17A | 3oi8A-4xdyA:undetectable | 3oi8A-4xdyA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xhj | ENVELOPEGLYCOPROTEIN H (Humanalphaherpesvirus3) |
PF02489(Herpes_glycop_H)PF17488(Herpes_glycoH_C) | 4 | ILE A 274HIS A 223PRO A 128LEU A 282 | None | 1.22A | 3oi8A-4xhjA:undetectable | 3oi8A-4xhjA:11.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4xz8 | NUCLEOPROTEIN (Thiaforaorthonairovirus) |
PF02477(Nairo_nucleo) | 4 | ILE A 296ASN A 220PRO A 122LEU A 127 | None | 1.11A | 3oi8A-4xz8A:undetectable | 3oi8A-4xz8A:16.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yet | SUPEROXIDE DISMUTASE (Babesia bovis) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 4 | ILE A 57ASN A 73PRO A 153LEU A 146 | None | 1.26A | 3oi8A-4yetA:undetectable | 3oi8A-4yetA:19.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yfh | DNA-BINDING PROTEINHU-ALPHA (Escherichiacoli) |
PF00216(Bac_DNA_binding) | 4 | ASN A 75HIS A 54PRO A 77ASP A 40 | None | 1.19A | 3oi8A-4yfhA:undetectable | 3oi8A-4yfhA:21.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ypj | BETA GALACTOSIDASE (Bacilluscirculans) |
PF00703(Glyco_hydro_2)PF02836(Glyco_hydro_2_C)PF02837(Glyco_hydro_2_N)PF16355(DUF4982) | 4 | ILE A 160ASN A 142LEU A 146ASP A 159 | None | 1.26A | 3oi8A-4ypjA:undetectable | 3oi8A-4ypjA:11.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 4 | HIS A 330PRO A 326LEU A 249ASP A 305 | ZN A 401 (-3.2A)NoneNoneNone | 1.19A | 3oi8A-4yu9A:undetectable | 3oi8A-4yu9A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yu9 | GLUTAMINYL-PEPTIDECYCLOTRANSFERASE (Homo sapiens) |
PF04389(Peptidase_M28) | 4 | ILE A 350HIS A 287PRO A 255LEU A 347 | None | 1.14A | 3oi8A-4yu9A:undetectable | 3oi8A-4yu9A:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3o | DNA TOPOISOMERASE 4SUBUNITB,PARE30-PARC55FUSED TOPO IV FROMS. PNEUMONIAE (Streptococcuspneumoniae) |
PF00521(DNA_topoisoIV)PF00986(DNA_gyraseB_C)PF01751(Toprim) | 4 | ILE A1219HIS A1181PRO A1209LEU A1482 | None | 1.26A | 3oi8A-4z3oA:undetectable | 3oi8A-4z3oA:12.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zke | SUPERKILLER PROTEIN7 (Saccharomycescerevisiae) |
PF00009(GTP_EFTU) | 4 | ILE A 655ASN A 727HIS A 678LEU A 657 | ILE A 655 ( 0.7A)ASN A 727 ( 0.6A)HIS A 678 ( 1.0A)LEU A 657 ( 0.6A) | 0.97A | 3oi8A-4zkeA:undetectable | 3oi8A-4zkeA:15.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bsw | 4-COUMARATE--COALIGASE 2 (Nicotianatabacum) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 4 | ILE A 255ASN A 86PRO A 88LEU A 44 | None | 1.03A | 3oi8A-5bswA:undetectable | 3oi8A-5bswA:16.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bza | BETA-N-ACETYLHEXOSAMINIDASE (Thermotoganeapolitana) |
PF00933(Glyco_hydro_3) | 4 | ILE A 400PRO A 392LEU A 420ASP A 396 | None | 1.18A | 3oi8A-5bzaA:undetectable | 3oi8A-5bzaA:18.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cr9 | ABC-TYPEFE3+-HYDROXAMATETRANSPORT SYSTEM,PERIPLASMICCOMPONENT (Saccharomonosporaviridis) |
PF01497(Peripla_BP_2) | 4 | ILE A 45ASN A 150PRO A 58LEU A 180 | None | 1.16A | 3oi8A-5cr9A:undetectable | 3oi8A-5cr9A:21.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5eft | P9-1 (Southern riceblack-streakeddwarf virus) |
PF06043(Reo_P9) | 4 | ILE B 14HIS B 206LEU B 48ASP B 215 | None | 1.00A | 3oi8A-5eftB:undetectable | 3oi8A-5eftB:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g06 | EXOSOME COMPLEXCOMPONENT CSL4 (Saccharomycescerevisiae) |
PF10447(EXOSC1) | 4 | ILE I 221ASN I 261PRO I 226LEU I 146 | None | 1.23A | 3oi8A-5g06I:undetectable | 3oi8A-5g06I:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h1z | PUTATIVE CYP ALKANEHYDROXYLASECYP153D17 (Sphingomonassp. PAMC 26605) |
PF00067(p450) | 4 | ASN A 136PRO A 138LEU A 383ASP A 262 | None | 1.07A | 3oi8A-5h1zA:undetectable | 3oi8A-5h1zA:18.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5k24 | METAL TRANSPORTERCNNM3 (Mus musculus) |
PF00571(CBS) | 4 | HIS C 352PRO C 356LEU C 440ASP C 445 | None | 0.93A | 3oi8A-5k24C:10.0 | 3oi8A-5k24C:29.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n57 | SUPEROXIDE DISMUTASE (Staphylococcusaureus) |
no annotation | 4 | ILE A 57ASN A 80PRO A 156LEU A 150 | None | 1.24A | 3oi8A-5n57A:undetectable | 3oi8A-5n57A:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o3m | PROTOCATECHUATEDECARBOXYLASE (Klebsiellapneumoniae) |
PF01977(UbiD) | 4 | ILE A 206HIS A 170PRO A 302LEU A 269 | None | 1.30A | 3oi8A-5o3mA:undetectable | 3oi8A-5o3mA:14.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oc1 | ARYL-ALCOHOL OXIDASE (Pleurotuseryngii) |
no annotation | 4 | ILE A 500PRO A 399LEU A 315ASP A 312 | ANN A 601 (-4.4A)GOL A 607 ( 4.3A)NoneNone | 1.18A | 3oi8A-5oc1A:undetectable | 3oi8A-5oc1A:15.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 4 | ASN B 36HIS B 65LEU B 77ASP B 150 | None | 1.28A | 3oi8A-5swiB:undetectable | 3oi8A-5swiB:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5swi | SUGAR HYDROLASE (Streptococcuspneumoniae) |
no annotation | 4 | ILE B 362ASN B 304PRO B 343LEU B 359 | None | 1.29A | 3oi8A-5swiB:undetectable | 3oi8A-5swiB:12.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ucy | TUBULIN ALPHA CHAIN (Tetrahymenathermophila) |
PF00091(Tubulin)PF03953(Tubulin_C) | 4 | ILE A 188ASN A 186PRO A 173LEU A 391 | None | 1.16A | 3oi8A-5ucyA:undetectable | 3oi8A-5ucyA:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vem | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Homo sapiens) |
PF01663(Phosphodiest) | 4 | ASN A 338HIS A 195PRO A 199ASP A 36 | None ZN A 502 (-3.2A)None ZN A 501 (-2.0A) | 1.05A | 3oi8A-5vemA:undetectable | 3oi8A-5vemA:16.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veo | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Mus musculus) |
PF01663(Phosphodiest) | 4 | ASN A 338HIS A 195PRO A 199ASP A 36 | None ZN A 501 ( 3.2A)None ZN A 502 ( 2.1A) | 1.03A | 3oi8A-5veoA:undetectable | 3oi8A-5veoA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5veo | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 5 (Mus musculus) |
PF01663(Phosphodiest) | 4 | ASN A 338HIS A 195PRO A 199ASP A 238 | None ZN A 501 ( 3.2A)None ZN A 502 ( 2.2A) | 1.21A | 3oi8A-5veoA:undetectable | 3oi8A-5veoA:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w1u | CARBOXYLIC ESTERHYDROLASE (Culexquinquefasciatus) |
PF00135(COesterase) | 4 | ILE A 332ASN A 382PRO A 377LEU A 339 | None | 1.25A | 3oi8A-5w1uA:undetectable | 3oi8A-5w1uA:13.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xbl | CRISPR-ASSOCIATEDENDONUCLEASECAS9/CSN1 (Streptococcuspyogenes) |
PF13395(HNH_4)PF16592(Cas9_REC)PF16593(Cas9-BH)PF16595(Cas9_PI) | 4 | ILE A 305HIS A 415PRO A 316LEU A 306 | None | 1.25A | 3oi8A-5xblA:undetectable | 3oi8A-5xblA:8.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xtb | NADH-UBIQUINONEOXIDOREDUCTASE 75KDA SUBUNIT,MITOCHONDRIAL (Homo sapiens) |
PF00384(Molybdopterin)PF09326(NADH_dhqG_C)PF10588(NADH-G_4Fe-4S_3)PF13510(Fer2_4) | 4 | ILE M 515ASN M 384PRO M 373LEU M 481 | None | 1.08A | 3oi8A-5xtbM:undetectable | 3oi8A-5xtbM:12.56 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5yz2 | MAGNESIUM AND COBALTEFFLUX PROTEIN CORC (Escherichiacoli) |
no annotation | 5 | ILE A 74HIS A 100PRO A 104LEU A 178ASP A 183 | AMP A 301 ( 4.2A)AMP A 301 (-3.4A)AMP A 301 ( 4.6A)NoneAMP A 301 (-1.9A) | 0.43A | 3oi8A-5yz2A:20.8 | 3oi8A-5yz2A:31.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c01 | ECTONUCLEOTIDEPYROPHOSPHATASE/PHOSPHODIESTERASE FAMILYMEMBER 3 (Homo sapiens) |
no annotation | 4 | ASN A 482HIS A 329PRO A 333ASP A 167 | None ZN A 901 ( 3.3A)None ZN A 902 (-2.0A) | 1.10A | 3oi8A-6c01A:undetectable | 3oi8A-6c01A:17.20 |