SIMILAR PATTERNS OF AMINO ACIDS FOR 3OHT_B_1N1B2000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lm5 SUBDOMAIN OF
DESMOPLAKIN
CARBOXY-TERMINAL
DOMAIN (DPCT)

(Homo sapiens) 		PF00681
(Plectin) 		5 ARG A2639
ILE A2641
ILE A2619
TYR A2785
ILE A2789
 None
 1.36A 3ohtA-1lm5A:
undetectable
3ohtB-1lm5A:
undetectable		 3ohtA-1lm5A:
19.08
3ohtB-1lm5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nee PROBABLE TRANSLATION
INITIATION FACTOR 2
BETA SUBUNIT

(Methanothermobacter
thermautotrophicus) 		PF01873
(eIF-5_eIF-2B) 		5 ARG A 114
ILE A 118
ILE A  92
ILE A  88
ASN A  52
 None
 1.43A 3ohtA-1neeA:
undetectable
3ohtB-1neeA:
undetectable		 3ohtA-1neeA:
18.18
3ohtB-1neeA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poy SPERMIDINE/PUTRESCIN
E-BINDING PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 ILE 1 243
ILE 1 291
ILE 1 130
ASN 1 230
VAL 1 245
 None
 1.32A 3ohtA-1poy1:
0.0
3ohtB-1poy1:
0.0		 3ohtA-1poy1:
22.50
3ohtB-1poy1:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqj OLIGOXYLOGLUCAN
REDUCING-END-SPECIFI
C CELLOBIOHYDROLASE

(Geotrichum sp.
M128) 		PF15899
(BNR_6) 		5 ARG A 451
ILE A 463
ILE A 466
MET A 469
VAL A 502
 None
 1.39A 3ohtA-1sqjA:
1.2
3ohtB-1sqjA:
0.9		 3ohtA-1sqjA:
18.12
3ohtB-1sqjA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x0l HOMOISOCITRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00180
(Iso_dh) 		5 ARG A 161
ILE A 157
ILE A  84
ASN A  96
VAL A 117
 None
 1.37A 3ohtA-1x0lA:
undetectable
3ohtB-1x0lA:
undetectable		 3ohtA-1x0lA:
21.43
3ohtB-1x0lA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2can ORNITHINE
AMINOTRANSFERASE

(Homo sapiens) 		PF00202
(Aminotran_3) 		5 ILE A 411
ILE A 432
ILE A 429
ASN A 378
VAL A 238
 None
 1.26A 3ohtA-2canA:
undetectable
3ohtB-2canA:
undetectable		 3ohtA-2canA:
22.05
3ohtB-2canA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7j SEP-TRNA:CYS-TRNA
SYNTHASE

(Archaeoglobus
fulgidus) 		PF05889
(SepSecS) 		5 ILE A 139
ILE A 117
TYR A 107
MET A  98
VAL A 178
 None
 1.41A 3ohtA-2e7jA:
0.0
3ohtB-2e7jA:
0.0		 3ohtA-2e7jA:
22.35
3ohtB-2e7jA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ec5 DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		5 ARG A 861
ILE A1023
TYR A1062
ILE A1027
ASN A 867
 None
 1.48A 3ohtA-2ec5A:
undetectable
3ohtB-2ec5A:
3.2		 3ohtA-2ec5A:
20.29
3ohtB-2ec5A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gza TYPE IV SECRETION
SYSTEM PROTEIN
VIRB11

(Brucella suis) 		PF00437
(T2SSE) 		5 ARG A 176
ILE A 256
ILE A 206
ARG A 255
VAL A 172
 None
 1.30A 3ohtA-2gzaA:
0.0
3ohtB-2gzaA:
0.0		 3ohtA-2gzaA:
22.82
3ohtB-2gzaA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 ILE A 264
ILE A 351
ILE A 372
ASN A 234
VAL A 271
 None
 1.21A 3ohtA-2odpA:
undetectable
3ohtB-2odpA:
undetectable		 3ohtA-2odpA:
21.00
3ohtB-2odpA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oox HYPOTHETICAL PROTEIN
C1556.08C IN
CHROMOSOME I

(Schizosaccharomyces
pombe) 		no annotation 5 ARG G 110
ILE G 115
ILE G  97
TYR G 246
ILE G  94
 None
 1.32A 3ohtA-2ooxG:
undetectable
3ohtB-2ooxG:
undetectable		 3ohtA-2ooxG:
19.90
3ohtB-2ooxG:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		5 ILE A 198
ILE A 145
ILE A 162
ASN A 212
VAL A 378
 None
 1.16A 3ohtA-2pefA:
undetectable
3ohtB-2pefA:
undetectable		 3ohtA-2pefA:
20.48
3ohtB-2pefA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdc UNCHARACTERIZED
PROTEIN

(Geobacter
sulfurreducens) 		PF11554
(DUF3232) 		5 ARG A 132
ILE A  30
ARG A  25
TRP A 138
MET A  23
 None
None
CL  A 153 (-3.3A)
None
None
 1.41A 3ohtA-2rdcA:
undetectable
3ohtB-2rdcA:
2.2		 3ohtA-2rdcA:
16.03
3ohtB-2rdcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdc UNCHARACTERIZED
PROTEIN

(Geobacter
sulfurreducens) 		PF11554
(DUF3232) 		5 ILE A 133
ILE A  30
ARG A  25
TRP A 138
MET A  23
 None
None
CL  A 153 (-3.3A)
None
None
 1.18A 3ohtA-2rdcA:
undetectable
3ohtB-2rdcA:
2.2		 3ohtA-2rdcA:
16.03
3ohtB-2rdcA:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbi ACYL-COA
DEHYDROGENASE FAMILY
MEMBER 11

(Homo sapiens) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ILE A 218
ILE A 249
ILE A 229
MET A 222
VAL A 256
 None
 1.36A 3ohtA-2wbiA:
undetectable
3ohtB-2wbiA:
undetectable		 3ohtA-2wbiA:
21.29
3ohtB-2wbiA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		5 ARG A 308
ILE A  73
ILE A  52
ASN A  77
VAL A 350
 None
 1.39A 3ohtA-2xn8A:
0.4
3ohtB-2xn8A:
undetectable		 3ohtA-2xn8A:
22.59
3ohtB-2xn8A:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrf METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Bacillus
subtilis) 		PF01008
(IF-2B) 		5 ILE A 328
ILE A 287
ILE A 289
ASN A 250
VAL A 270
 None
 1.44A 3ohtA-2yrfA:
undetectable
3ohtB-2yrfA:
undetectable		 3ohtA-2yrfA:
23.65
3ohtB-2yrfA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zl5 58 KD CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 ILE A 290
TYR A 343
ILE A 299
ARG A 291
MET A 332
 None
 1.38A 3ohtA-2zl5A:
undetectable
3ohtB-2zl5A:
undetectable		 3ohtA-2zl5A:
20.97
3ohtB-2zl5A:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fht ATP-DEPENDENT RNA
HELICASE DDX19B

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 ILE A 307
ILE A 455
ILE A 451
ASN A 407
VAL A 405
 None
 1.46A 3ohtA-3fhtA:
undetectable
3ohtB-3fhtA:
undetectable		 3ohtA-3fhtA:
21.87
3ohtB-3fhtA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 378
ILE A 333
TYR A 339
ILE A 353
MET A 412
 None
 1.22A 3ohtA-3gg4A:
undetectable
3ohtB-3gg4A:
undetectable		 3ohtA-3gg4A:
23.01
3ohtB-3gg4A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ghy KETOPANTOATE
REDUCTASE PROTEIN

(Ralstonia
solanacearum) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 ILE A 134
ILE A 197
ILE A 165
TRP A 108
VAL A  74
 None
 1.42A 3ohtA-3ghyA:
1.3
3ohtB-3ghyA:
undetectable		 3ohtA-3ghyA:
20.40
3ohtB-3ghyA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mt1 PUTATIVE
CARBOXYNORSPERMIDINE
DECARBOXYLASE
PROTEIN

(Sinorhizobium
meliloti) 		PF00278
(Orn_DAP_Arg_deC) 		5 ILE A 188
ILE A  97
ILE A  96
ASN A 157
VAL A 191
 None
 1.47A 3ohtA-3mt1A:
undetectable
3ohtB-3mt1A:
undetectable		 3ohtA-3mt1A:
22.36
3ohtB-3mt1A:
22.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		5 ARG A 197
ILE A 201
ILE A 122
ILE A 119
MET A 214
 None
 1.48A 3ohtA-3oz6A:
7.1
3ohtB-3oz6A:
9.2		 3ohtA-3oz6A:
33.18
3ohtB-3oz6A:
33.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 ILE A 237
ILE A 481
ILE A 485
MET A 436
VAL A 235
 None
 1.21A 3ohtA-3rreA:
undetectable
3ohtB-3rreA:
undetectable		 3ohtA-3rreA:
21.60
3ohtB-3rreA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udb SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A 183
ILE A 257
ILE A 266
TRP A 201
VAL A 187
 None
 1.44A 3ohtA-3udbA:
6.1
3ohtB-3udbA:
6.1		 3ohtA-3udbA:
23.60
3ohtB-3udbA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujg SERINE/THREONINE-PRO
TEIN KINASE SRK2E

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		5 ILE A 183
ILE A 257
ILE A 266
TRP A 201
VAL A 187
 None
 1.44A 3ohtA-3ujgA:
17.5
3ohtB-3ujgA:
6.1		 3ohtA-3ujgA:
25.71
3ohtB-3ujgA:
25.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulk KETOL-ACID
REDUCTOISOMERASE

(Escherichia
coli) 		PF01450
(IlvC)
PF07991
(IlvN) 		5 ILE A  96
ILE A 143
ILE A 136
ASN A 104
VAL A  43
 ILE  A  96 ( 0.7A)
ILE  A 143 ( 0.7A)
ILE  A 136 ( 0.7A)
ASN  A 104 ( 0.6A)
VAL  A  43 ( 0.6A)
 1.24A 3ohtA-3ulkA:
undetectable
3ohtB-3ulkA:
undetectable		 3ohtA-3ulkA:
22.80
3ohtB-3ulkA:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wy2 ALPHA-GLUCOSIDASE

(Halomonas sp.
H11) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		5 ARG A 280
ILE A 272
ILE A 146
TYR A 389
VAL A 204
 GOL  A 603 (-4.2A)
None
None
None
None
 1.46A 3ohtA-3wy2A:
undetectable
3ohtB-3wy2A:
2.0		 3ohtA-3wy2A:
20.94
3ohtB-3wy2A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l8k PUTATIVE PEPTIDASE

(Parabacteroides
merdae) 		PF03572
(Peptidase_S41)
PF14684
(Tricorn_C1) 		5 ILE A 300
ILE A 320
ILE A 321
MET A 259
VAL A 247
 None
 1.37A 3ohtA-4l8kA:
1.6
3ohtB-4l8kA:
1.7		 3ohtA-4l8kA:
21.41
3ohtB-4l8kA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mnm CHITINASE A

(Cycas revoluta) 		PF00704
(Glyco_hydro_18) 		5 ILE A 237
ILE A 273
ILE A 277
ASN A 305
VAL A 309
 None
 1.43A 3ohtA-4mnmA:
undetectable
3ohtB-4mnmA:
undetectable		 3ohtA-4mnmA:
22.57
3ohtB-4mnmA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5h PHENYLACETALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		5 ILE A 246
ILE A 187
ILE A 216
ASN A 227
VAL A  66
 None
 1.35A 3ohtA-4o5hA:
undetectable
3ohtB-4o5hA:
undetectable		 3ohtA-4o5hA:
21.47
3ohtB-4o5hA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ryb 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Neisseria
meningitidis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ARG A 251
ILE A 254
ILE A 296
TYR A 320
ILE A 291
 None
 1.43A 3ohtA-4rybA:
undetectable
3ohtB-4rybA:
undetectable		 3ohtA-4rybA:
20.20
3ohtB-4rybA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1

(Plasmodium
knowlesi) 		PF02430
(AMA-1) 		5 ILE A 320
ILE A 135
ILE A 138
MET A 194
VAL A 114
 None
 1.18A 3ohtA-4uv6A:
undetectable
3ohtB-4uv6A:
undetectable		 3ohtA-4uv6A:
23.11
3ohtB-4uv6A:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PIGG

(Escherichia
coli;
Serratia) 		PF13416
(SBP_bac_8) 		5 ARG A 420
ILE A 427
ILE A 383
ILE A 380
VAL A 447
 None
 1.48A 3ohtA-5gxvA:
undetectable
3ohtB-5gxvA:
undetectable		 3ohtA-5gxvA:
21.31
3ohtB-5gxvA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7j ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 ILE A 472
ILE A 501
ILE A 510
MET A 546
VAL A 582
 None
 1.39A 3ohtA-5h7jA:
undetectable
3ohtB-5h7jA:
undetectable		 3ohtA-5h7jA:
12.30
3ohtB-5h7jA:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hab RIBONUCLEASE J

(Methanolobus
psychrophilus) 		PF07521
(RMMBL)
PF12706
(Lactamase_B_2) 		5 ILE A  31
ILE A 154
TYR A 107
ILE A 155
VAL A 160
 None
 1.15A 3ohtA-5habA:
undetectable
3ohtB-5habA:
undetectable		 3ohtA-5habA:
22.51
3ohtB-5habA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i51 TRANSKETOLASE

(Scheffersomyces
stipitis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 ARG A  59
ILE A 126
MET A 422
ASN A 423
VAL A 111
 None
 1.30A 3ohtA-5i51A:
undetectable
3ohtB-5i51A:
undetectable		 3ohtA-5i51A:
22.08
3ohtB-5i51A:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 ARG A1170
ILE A1116
ILE A1140
TYR A1050
ILE A1042
 None
 1.46A 3ohtA-5m59A:
undetectable
3ohtB-5m59A:
undetectable		 3ohtA-5m59A:
12.66
3ohtB-5m59A:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wax -

(-) 		no annotation 5 ILE A 175
ILE A 249
ILE A 258
TRP A 193
VAL A 179
 None
 1.46A 3ohtA-5waxA:
6.1
3ohtB-5waxA:
5.9		 3ohtA-5waxA:
undetectable
3ohtB-5waxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqw N-ACETYLGLUCOSAMINID
ASE

(Clostridium
perfringens) 		PF01832
(Glucosaminidase) 		5 ILE A1090
TYR A 964
ILE A1104
ARG A1082
MET A1081
 EDO  A1201 (-4.8A)
None
None
EDO  A1201 ( 4.4A)
EDO  A1206 (-3.2A)
 1.41A 3ohtA-5wqwA:
undetectable
3ohtB-5wqwA:
undetectable		 3ohtA-5wqwA:
23.74
3ohtB-5wqwA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wrj PROTEIN-TYROSINE
SULFOTRANSFERASE 1

(Homo sapiens) 		PF13469
(Sulfotransfer_3) 		5 ILE A 272
ILE A  95
ILE A  72
ARG A  86
VAL A 290
 None
None
None
None
A3P  A 401 (-4.0A)
 1.10A 3ohtA-5wrjA:
undetectable
3ohtB-5wrjA:
undetectable		 3ohtA-5wrjA:
22.86
3ohtB-5wrjA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus) 		no annotation 5 ILE L 157
ILE L  98
ARG L  99
MET L 154
VAL L  80
 None
 1.38A 3ohtA-6cfwL:
1.7
3ohtB-6cfwL:
2.0		 3ohtA-6cfwL:
14.13
3ohtB-6cfwL:
14.13