SIMILAR PATTERNS OF AMINO ACIDS FOR 3OHT_B_1N1B1000_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Plasmodium
falciparum)
PF00274
(Glycolytic)
3 GLU A 194
LEU A 277
LEU A  36
None
0.68A 3ohtB-1a5cA:
undetectable
3ohtB-1a5cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis)
PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N)
3 GLU A 235
LEU A  83
LEU A 157
None
0.70A 3ohtB-1ciyA:
undetectable
3ohtB-1ciyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)


(Physarum
polycephalum)
PF09192
(Act-Frag_cataly)
3 GLU A 106
LEU A 160
LEU A 164
None
None
AMP  A 425 ( 4.8A)
0.62A 3ohtB-1cjaA:
4.0
3ohtB-1cjaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)


(Plasmodium
falciparum)
PF00156
(Pribosyltran)
3 GLU A 144
LEU A 153
LEU A 180
IRP  A 300 (-2.8A)
None
None
0.76A 3ohtB-1cjbA:
undetectable
3ohtB-1cjbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN


(Equus caballus)
PF00626
(Gelsolin)
3 GLU A  28
LEU A  33
LEU A  71
None
0.69A 3ohtB-1d0nA:
undetectable
3ohtB-1d0nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE


(Leishmania
mexicana)
PF00274
(Glycolytic)
3 GLU A 197
LEU A 280
LEU A  40
None
0.72A 3ohtB-1epxA:
undetectable
3ohtB-1epxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL


(Trypanosoma
brucei)
PF00274
(Glycolytic)
3 GLU A 197
LEU A 280
LEU A  40
None
0.75A 3ohtB-1f2jA:
undetectable
3ohtB-1f2jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE


(Drosophila
melanogaster)
PF00274
(Glycolytic)
3 GLU A 187
LEU A 270
LEU A  30
None
0.74A 3ohtB-1fbaA:
undetectable
3ohtB-1fbaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE


(Oryctolagus
cuniculus)
PF00274
(Glycolytic)
3 GLU A1187
LEU A1270
LEU A1030
2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
0.77A 3ohtB-1fdjA:
undetectable
3ohtB-1fdjA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
3 GLU A 236
LEU A  30
LEU A  23
GLU  A 236 ( 0.6A)
LEU  A  30 ( 0.6A)
LEU  A  23 ( 0.6A)
0.67A 3ohtB-1fxjA:
undetectable
3ohtB-1fxjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 GLU A  38
LEU A 229
LEU A 260
None
0.62A 3ohtB-1i2dA:
undetectable
3ohtB-1i2dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum)
PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 GLU A 130
LEU A 147
LEU A 229
None
0.76A 3ohtB-1i2dA:
undetectable
3ohtB-1i2dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE


(Escherichia
coli)
PF00218
(IGPS)
3 GLU P 214
LEU P 161
LEU P 176
None
0.61A 3ohtB-1jcmP:
undetectable
3ohtB-1jcmP:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 GLU A 128
LEU A 145
LEU A 227
None
None
TRS  A1415 ( 4.6A)
0.74A 3ohtB-1jedA:
undetectable
3ohtB-1jedA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I


(Escherichia
coli)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
3 GLU A  19
LEU A 231
LEU A 412
None
0.67A 3ohtB-1k0gA:
undetectable
3ohtB-1k0gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae)
PF00668
(Condensation)
3 GLU A 314
LEU A   3
LEU A  62
None
0.58A 3ohtB-1l5aA:
undetectable
3ohtB-1l5aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT
GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT


(Klebsiella
pneumoniae)
PF02288
(Dehydratase_MU)
PF08841
(DDR)
3 GLU B  30
LEU A 172
LEU A 181
None
0.63A 3ohtB-1nbwB:
undetectable
3ohtB-1nbwB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT


(Pseudomonas
putida)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
3 GLU B 174
LEU B  12
LEU B  20
None
0.72A 3ohtB-1qs0B:
undetectable
3ohtB-1qs0B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE


(Saccharomyces
cerevisiae)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2)
3 GLU A 128
LEU A 145
LEU A 227
None
0.75A 3ohtB-1r6xA:
undetectable
3ohtB-1r6xA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE


(Pseudomonas
aeruginosa)
PF16363
(GDP_Man_Dehyd)
3 GLU A 128
LEU A 286
LEU A 305
GDP  A1601 (-3.7A)
None
None
0.77A 3ohtB-1rpnA:
undetectable
3ohtB-1rpnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe)
PF00307
(CH)
3 GLU A 117
LEU A 351
LEU A 359
None
0.76A 3ohtB-1rt8A:
undetectable
3ohtB-1rt8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
3 GLU A 138
LEU A 229
LEU A 201
None
0.61A 3ohtB-1sv6A:
undetectable
3ohtB-1sv6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus)
PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc)
3 GLU A 434
LEU A 379
LEU A 412
None
0.70A 3ohtB-1taqA:
3.9
3ohtB-1taqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE


(Escherichia
coli)
PF00291
(PALP)
PF00585
(Thr_dehydrat_C)
3 GLU A 308
LEU A 310
LEU A 174
None
0.62A 3ohtB-1tdjA:
undetectable
3ohtB-1tdjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN


(Plexaura
homomalla)
no annotation 3 GLU A 226
LEU A 190
LEU A 271
None
0.74A 3ohtB-1u5uA:
undetectable
3ohtB-1u5uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE


(Ruminiclostridium
thermocellum)
PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
3 GLU A 406
LEU A 629
LEU A 634
None
0.65A 3ohtB-1ut9A:
undetectable
3ohtB-1ut9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus)
PF01085
(HH_signal)
3 GLU A  54
LEU A 140
LEU A 107
None
0.64A 3ohtB-1vhhA:
undetectable
3ohtB-1vhhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE


(Thermotoga
maritima)
PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC)
3 GLU A 128
LEU A 152
LEU A 269
None
0.77A 3ohtB-1vknA:
undetectable
3ohtB-1vknA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE


(Bacillus
subtilis)
PF03102
(NeuB)
PF08666
(SAF)
3 GLU A 163
LEU A 136
LEU A 343
None
0.78A 3ohtB-1vliA:
undetectable
3ohtB-1vliA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis)
PF01430
(HSP33)
3 GLU A 199
LEU A 204
LEU A 170
None
0.66A 3ohtB-1vzyA:
undetectable
3ohtB-1vzyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2


(Homo sapiens)
PF03114
(BAR)
3 GLU A 162
LEU A 166
LEU A 187
None
0.54A 3ohtB-1x03A:
2.0
3ohtB-1x03A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens)
PF00274
(Glycolytic)
3 GLU A 188
LEU A 271
LEU A  31
None
0.77A 3ohtB-1xfbA:
undetectable
3ohtB-1xfbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  64
LEU A  91
LEU A  95
None
0.67A 3ohtB-1zwsA:
6.4
3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  64
LEU A  91
LEU A  95
None
0.53A 3ohtB-2a2aA:
3.2
3ohtB-2a2aA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR


(Escherichia
coli)
no annotation 3 GLU A 304
LEU A 300
LEU A  76
None
0.76A 3ohtB-2b2nA:
undetectable
3ohtB-2b2nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE


(Chlorobaculum
tepidum)
PF00106
(adh_short)
3 GLU A  33
LEU A  59
LEU A  20
None
0.70A 3ohtB-2bd0A:
undetectable
3ohtB-2bd0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D


(Caenorhabditis
elegans)
PF00069
(Pkinase)
3 GLU A  60
LEU A  87
LEU A  91
None
0.44A 3ohtB-2bdwA:
5.5
3ohtB-2bdwA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR


(Sus scrofa)
PF13516
(LRR_6)
3 GLU A 294
LEU A 298
LEU A 330
None
0.62A 3ohtB-2bnhA:
undetectable
3ohtB-2bnhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2


(Rattus
norvegicus)
PF03114
(BAR)
3 GLU A 162
LEU A 166
LEU A 187
None
0.46A 3ohtB-2c08A:
2.1
3ohtB-2c08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe)
PF00069
(Pkinase)
3 GLU A  55
LEU A  83
LEU A  87
None
0.76A 3ohtB-2csnA:
4.0
3ohtB-2csnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA


(Escherichia
coli)
PF03054
(tRNA_Me_trans)
3 GLU A 352
LEU A 142
LEU A 173
None
0.73A 3ohtB-2detA:
undetectable
3ohtB-2detA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis)
PF02255
(PTS_IIA)
3 GLU A  12
LEU A   8
LEU A  70
None
0.53A 3ohtB-2e2aA:
2.7
3ohtB-2e2aA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE


(Escherichia
coli)
PF01557
(FAA_hydrolase)
3 GLU A 139
LEU A 236
LEU A 208
MG  A1001 ( 3.0A)
None
None
0.72A 3ohtB-2eb5A:
undetectable
3ohtB-2eb5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2


(Homo sapiens)
PF00071
(Ras)
3 GLU A  48
LEU A  67
LEU A  91
None
0.73A 3ohtB-2eryA:
undetectable
3ohtB-2eryA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR


(Molluscum
contagiosum
virus)
PF01335
(DED)
3 GLU A 105
LEU A  27
LEU A  72
None
0.69A 3ohtB-2f1sA:
undetectable
3ohtB-2f1sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1


(Danio rerio)
PF04564
(U-box)
3 GLU A 239
LEU A 261
LEU A 265
None
0.75A 3ohtB-2f42A:
3.5
3ohtB-2f42A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS


(Homo sapiens)
PF00071
(Ras)
3 GLU A  63
LEU A  82
LEU A  45
None
0.77A 3ohtB-2fn4A:
undetectable
3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS


(Homo sapiens)
PF00071
(Ras)
3 GLU A  63
LEU A  82
LEU A 106
None
0.65A 3ohtB-2fn4A:
undetectable
3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr2 HYPOTHETICAL PROTEIN
RV2717C


(Mycobacterium
tuberculosis)
PF08768
(DUF1794)
3 GLU A  67
LEU A  83
LEU A 118
None
0.53A 3ohtB-2fr2A:
undetectable
3ohtB-2fr2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN


(Pedobacter
heparinus)
PF07940
(Hepar_II_III)
PF16332
(DUF4962)
3 GLU A 651
LEU A 647
LEU A 422
None
0.72A 3ohtB-2fuqA:
2.7
3ohtB-2fuqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis)
PF01274
(Malate_synthase)
3 GLU A 597
LEU A 643
LEU A 698
None
0.74A 3ohtB-2gq3A:
undetectable
3ohtB-2gq3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN


(Bacteroides
thetaiotaomicron)
PF09924
(DUF2156)
3 GLU A 172
LEU A 194
LEU A  40
None
0.63A 3ohtB-2hqyA:
undetectable
3ohtB-2hqyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE


(Thermotoga
maritima)
PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C)
3 GLU A  39
LEU A  12
LEU A 128
None
0.61A 3ohtB-2hxvA:
undetectable
3ohtB-2hxvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster)
PF01085
(HH_signal)
3 GLU E 113
LEU E 199
LEU E 166
None
0.68A 3ohtB-2ibgE:
undetectable
3ohtB-2ibgE:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN


(Homo sapiens)
PF11510
(FA_FANCE)
3 GLU A 506
LEU A 510
LEU A 476
None
0.59A 3ohtB-2ilrA:
undetectable
3ohtB-2ilrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9v DERMONECROTIC TOXIN

(Pasteurella
multocida)
PF11647
(MLD)
3 GLU A  42
LEU A  40
LEU A  50
None
0.74A 3ohtB-2n9vA:
undetectable
3ohtB-2n9vA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B


(Saccharomyces
cerevisiae)
PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C)
3 GLU H  87
LEU H  83
LEU H  18
None
0.72A 3ohtB-2noqH:
undetectable
3ohtB-2noqH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE


(Lactobacillus
reuteri)
PF01923
(Cob_adeno_trans)
3 GLU A 135
LEU A 152
LEU A  65
None
0.78A 3ohtB-2nt8A:
undetectable
3ohtB-2nt8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)


(Tribolium
castaneum)
PF00104
(Hormone_recep)
3 GLU E 473
LEU E 383
LEU E 391
None
0.77A 3ohtB-2nxxE:
undetectable
3ohtB-2nxxE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE


(Homo sapiens)
PF01712
(dNK)
3 GLU A 211
LEU A 203
LEU A 192
DTP  A 301 (-3.5A)
None
None
0.65A 3ohtB-2ocpA:
undetectable
3ohtB-2ocpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU


(Escherichia
coli)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
3 GLU A 236
LEU A  30
LEU A  23
None
0.69A 3ohtB-2oi6A:
undetectable
3ohtB-2oi6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29)
PF03175
(DNA_pol_B_2)
3 GLU A 221
LEU A 351
LEU A 333
None
None
EDO  A2771 (-4.8A)
0.65A 3ohtB-2pyjA:
undetectable
3ohtB-2pyjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA


(Escherichia
virus T4)
PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT)
3 GLU B 157
LEU B  24
LEU B  62
MN  B 257 (-2.9A)
None
None
0.74A 3ohtB-2qb0B:
2.2
3ohtB-2qb0B:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1i GCN5-RELATED
N-ACETYLTRANSFERASE


(Arthrobacter
sp. FB24)
PF00583
(Acetyltransf_1)
3 GLU A 134
LEU A 132
LEU A 124
None
GOL  A 177 (-4.3A)
None
0.75A 3ohtB-2r1iA:
undetectable
3ohtB-2r1iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli)
PF00154
(RecA)
3 GLU A 154
LEU A 166
LEU A 126
None
0.76A 3ohtB-2rebA:
undetectable
3ohtB-2rebA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN


(Shigella
flexneri)
PF07063
(DUF1338)
3 GLU A 272
LEU A 270
LEU A 225
None
0.73A 3ohtB-2rjbA:
undetectable
3ohtB-2rjbA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  64
LEU A  91
LEU A  95
ADP  A1303 ( 4.8A)
None
None
0.49A 3ohtB-2w4kA:
5.0
3ohtB-2w4kA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A 459
LEU A 487
LEU A 491
None
0.71A 3ohtB-2wntA:
5.6
3ohtB-2wntA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE


(Rhodospirillum
rubrum)
PF03747
(ADP_ribosyl_GH)
3 GLU A 277
LEU A  15
LEU A  23
None
0.60A 3ohtB-2wocA:
undetectable
3ohtB-2wocA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM


(Mus musculus)
PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B)
3 GLU A1029
LEU A1032
LEU A1022
None
0.77A 3ohtB-2y3aA:
2.5
3ohtB-2y3aA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2


(Mus musculus)
PF00069
(Pkinase)
3 GLU A  64
LEU A  91
LEU A  95
None
None
AMP  A1302 ( 4.9A)
0.52A 3ohtB-2yabA:
5.5
3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
3 GLU A 361
LEU A 365
LEU A 377
None
0.73A 3ohtB-2ywbA:
2.0
3ohtB-2ywbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE


(Thermococcus
litoralis)
PF00155
(Aminotran_1_2)
3 GLU A  79
LEU A 288
LEU A  62
None
0.71A 3ohtB-2zc0A:
undetectable
3ohtB-2zc0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus)
PF01351
(RNase_HII)
PF11858
(DUF3378)
3 GLU A  74
LEU A  52
LEU A  33
None
0.71A 3ohtB-3asmA:
undetectable
3ohtB-3asmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A


(Mus musculus)
PF00071
(Ras)
3 GLU A 161
LEU A 101
LEU A 108
None
0.70A 3ohtB-3bc1A:
undetectable
3ohtB-3bc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  61
LEU A  88
LEU A  92
None
None
5CP  A 600 (-4.6A)
0.65A 3ohtB-3bhhA:
5.8
3ohtB-3bhhA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A


(Oryctolagus
cuniculus)
PF00274
(Glycolytic)
3 GLU A 187
LEU A 270
LEU A  30
None
13P  A3371 (-3.8A)
None
0.77A 3ohtB-3bv4A:
undetectable
3ohtB-3bv4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN


(Homo sapiens)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha)
3 GLU B 313
LEU B 311
LEU B 294
None
0.75A 3ohtB-3bvhB:
undetectable
3ohtB-3bvhB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae)
PF00923
(TAL_FSA)
3 GLU A 122
LEU A 112
LEU A 163
None
0.48A 3ohtB-3clmA:
undetectable
3ohtB-3clmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1


(Homo sapiens)
PF01287
(eIF-5a)
3 GLU A 144
LEU A 112
LEU A 134
UNX  A   5 (-3.9A)
UNX  A   1 (-4.1A)
None
0.76A 3ohtB-3cpfA:
undetectable
3ohtB-3cpfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS


(Drosophila
melanogaster)
PF07679
(I-set)
PF13927
(Ig_3)
3 GLU A 165
LEU A 234
LEU A 217
None
0.78A 3ohtB-3dmkA:
undetectable
3ohtB-3dmkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)


(Aquifex
aeolicus)
PF00072
(Response_reg)
PF00158
(Sigma54_activat)
3 GLU A 135
LEU A 140
LEU A 299
None
0.73A 3ohtB-3dzdA:
undetectable
3ohtB-3dzdA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE


(Clostridium
acetobutylicum)
PF00881
(Nitroreductase)
3 GLU A  97
LEU A 101
LEU A  27
None
0.77A 3ohtB-3e10A:
undetectable
3ohtB-3e10A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE


(Escherichia
coli)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg)
3 GLU A 385
LEU A 420
LEU A 412
None
0.73A 3ohtB-3e2sA:
undetectable
3ohtB-3e2sA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  73
LEU A 106
LEU A 110
None
None
35F  A   1 (-4.5A)
0.42A 3ohtB-3e7oA:
8.1
3ohtB-3e7oA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE


(Brucella
abortus)
PF00171
(Aldedh)
3 GLU A 198
LEU A  15
LEU A 188
None
0.66A 3ohtB-3ek1A:
undetectable
3ohtB-3ek1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek3 NITROREDUCTASE

(Bacteroides
fragilis)
PF00881
(Nitroreductase)
3 GLU A 117
LEU A 121
LEU A  33
None
0.62A 3ohtB-3ek3A:
undetectable
3ohtB-3ek3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1


(Saccharomyces
cerevisiae)
PF08311
(Mad3_BUB1_I)
3 GLU A 198
LEU A 160
LEU A 168
None
0.69A 3ohtB-3eslA:
undetectable
3ohtB-3eslA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euc HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE 2


(Cupriavidus
pinatubonensis)
PF00155
(Aminotran_1_2)
3 GLU A 269
LEU A 265
LEU A 229
None
0.78A 3ohtB-3eucA:
undetectable
3ohtB-3eucA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2i ALR0221 PROTEIN

(Nostoc sp. PCC
7120)
PF00300
(His_Phos_1)
3 GLU A  75
LEU A  49
LEU A   5
None
0.64A 3ohtB-3f2iA:
undetectable
3ohtB-3f2iA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159


(Corynebacterium
glutamicum)
no annotation 3 GLU A 182
LEU A 243
LEU A  44
None
0.71A 3ohtB-3fokA:
undetectable
3ohtB-3fokA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU


(Yersinia pestis)
PF00132
(Hexapep)
PF12804
(NTP_transf_3)
3 GLU A 236
LEU A  30
LEU A  23
None
0.69A 3ohtB-3fwwA:
undetectable
3ohtB-3fwwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE


(Methanocaldococcus
jannaschii)
PF00398
(RrnaAD)
3 GLU A  36
LEU A  48
LEU A  74
None
0.61A 3ohtB-3fydA:
undetectable
3ohtB-3fydA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE


([Candida]
glabrata)
PF01507
(PAPS_reduct)
3 GLU A 210
LEU A   9
LEU A  78
None
0.75A 3ohtB-3g5aA:
undetectable
3ohtB-3g5aA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE


(Gloeobacter
violaceus)
PF00185
(OTCace)
PF02729
(OTCace_N)
3 GLU A 150
LEU A 146
LEU A 160
None
0.75A 3ohtB-3gd5A:
undetectable
3ohtB-3gd5A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11


(Homo sapiens)
PF00069
(Pkinase)
3 GLU A  71
LEU A 104
LEU A 108
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
0.33A 3ohtB-3gp0A:
32.9
3ohtB-3gp0A:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE


(Methanocaldococcus
jannaschii)
PF00398
(RrnaAD)
3 GLU A  36
LEU A  48
LEU A  74
SAM  A 300 (-4.4A)
None
None
0.62A 3ohtB-3gryA:
undetectable
3ohtB-3gryA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE


(Shigella
flexneri)
PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C)
3 GLU A 282
LEU A 240
LEU A 226
None
0.73A 3ohtB-3h2zA:
undetectable
3ohtB-3h2zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h92 UNCHARACTERIZED
ATP-BINDING PROTEIN
MJECL15


(Methanocaldococcus
jannaschii)
no annotation 3 GLU A  65
LEU A  20
LEU A  83
None
0.74A 3ohtB-3h92A:
undetectable
3ohtB-3h92A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE


(Shewanella
denitrificans)
PF01380
(SIS)
3 GLU A 227
LEU A 223
LEU A 256
None
0.77A 3ohtB-3hbaA:
undetectable
3ohtB-3hbaA:
21.14