SIMILAR PATTERNS OF AMINO ACIDS FOR 3OHT_B_1N1B1000_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1a5c | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Plasmodiumfalciparum) |
PF00274(Glycolytic) | 3 | GLU A 194LEU A 277LEU A 36 | None | 0.68A | 3ohtB-1a5cA:undetectable | 3ohtB-1a5cA:22.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ciy | CRYIA(A) (Bacillusthuringiensis) |
PF00555(Endotoxin_M)PF03944(Endotoxin_C)PF03945(Endotoxin_N) | 3 | GLU A 235LEU A 83LEU A 157 | None | 0.70A | 3ohtB-1ciyA:undetectable | 3ohtB-1ciyA:20.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cja | PROTEIN(ACTIN-FRAGMINKINASE) (Physarumpolycephalum) |
PF09192(Act-Frag_cataly) | 3 | GLU A 106LEU A 160LEU A 164 | NoneNoneAMP A 425 ( 4.8A) | 0.62A | 3ohtB-1cjaA:4.0 | 3ohtB-1cjaA:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cjb | PROTEIN(HYPOXANTHINE-GUANINEPHOSPHORIBOSYLTRANSFERASE) (Plasmodiumfalciparum) |
PF00156(Pribosyltran) | 3 | GLU A 144LEU A 153LEU A 180 | IRP A 300 (-2.8A)NoneNone | 0.76A | 3ohtB-1cjbA:undetectable | 3ohtB-1cjbA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1d0n | HORSE PLASMAGELSOLIN (Equus caballus) |
PF00626(Gelsolin) | 3 | GLU A 28LEU A 33LEU A 71 | None | 0.69A | 3ohtB-1d0nA:undetectable | 3ohtB-1d0nA:19.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1epx | FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE (Leishmaniamexicana) |
PF00274(Glycolytic) | 3 | GLU A 197LEU A 280LEU A 40 | None | 0.72A | 3ohtB-1epxA:undetectable | 3ohtB-1epxA:25.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1f2j | FRUCTOSE-BISPHOSPHATE ALDOLASE,GLYCOSOMAL (Trypanosomabrucei) |
PF00274(Glycolytic) | 3 | GLU A 197LEU A 280LEU A 40 | None | 0.75A | 3ohtB-1f2jA:undetectable | 3ohtB-1f2jA:21.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fba | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Drosophilamelanogaster) |
PF00274(Glycolytic) | 3 | GLU A 187LEU A 270LEU A 30 | None | 0.74A | 3ohtB-1fbaA:undetectable | 3ohtB-1fbaA:19.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fdj | FRUCTOSE1,6-BISPHOSPHATEALDOLASE (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 3 | GLU A1187LEU A1270LEU A1030 | 2FP A5001 (-4.3A)2FP A5001 ( 3.9A)None | 0.77A | 3ohtB-1fdjA:undetectable | 3ohtB-1fdjA:23.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1fxj | UDP-N-ACETYLGLUCOSAMINEPYROPHOSPHORYLASE (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 3 | GLU A 236LEU A 30LEU A 23 | GLU A 236 ( 0.6A)LEU A 30 ( 0.6A)LEU A 23 ( 0.6A) | 0.67A | 3ohtB-1fxjA:undetectable | 3ohtB-1fxjA:20.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i2d | ATP SULFURYLASE (Penicilliumchrysogenum) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | GLU A 38LEU A 229LEU A 260 | None | 0.62A | 3ohtB-1i2dA:undetectable | 3ohtB-1i2dA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i2d | ATP SULFURYLASE (Penicilliumchrysogenum) |
PF01583(APS_kinase)PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | GLU A 130LEU A 147LEU A 229 | None | 0.76A | 3ohtB-1i2dA:undetectable | 3ohtB-1i2dA:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jcm | INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE (Escherichiacoli) |
PF00218(IGPS) | 3 | GLU P 214LEU P 161LEU P 176 | None | 0.61A | 3ohtB-1jcmP:undetectable | 3ohtB-1jcmP:20.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jed | SULFATEADENYLYLTRANSFERASE (Saccharomycescerevisiae) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | GLU A 128LEU A 145LEU A 227 | NoneNoneTRS A1415 ( 4.6A) | 0.74A | 3ohtB-1jedA:undetectable | 3ohtB-1jedA:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k0g | P-AMINOBENZOATESYNTHASE COMPONENT I (Escherichiacoli) |
PF00425(Chorismate_bind)PF04715(Anth_synt_I_N) | 3 | GLU A 19LEU A 231LEU A 412 | None | 0.67A | 3ohtB-1k0gA:undetectable | 3ohtB-1k0gA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 3 | GLU A 314LEU A 3LEU A 62 | None | 0.58A | 3ohtB-1l5aA:undetectable | 3ohtB-1l5aA:23.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nbw | GLYCEROL DEHYDRATASEREACTIVASE ALPHASUBUNITGLYCEROL DEHYDRATASEREACTIVASE BETASUBUNIT (Klebsiellapneumoniae) |
PF02288(Dehydratase_MU)PF08841(DDR) | 3 | GLU B 30LEU A 172LEU A 181 | None | 0.63A | 3ohtB-1nbwB:undetectable | 3ohtB-1nbwB:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qs0 | 2-OXOISOVALERATEDEHYDROGENASEBETA-SUBUNIT (Pseudomonasputida) |
PF02779(Transket_pyr)PF02780(Transketolase_C) | 3 | GLU B 174LEU B 12LEU B 20 | None | 0.72A | 3ohtB-1qs0B:undetectable | 3ohtB-1qs0B:20.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r6x | ATP:SULFATEADENYLYLTRANSFERASE (Saccharomycescerevisiae) |
PF01747(ATP-sulfurylase)PF14306(PUA_2) | 3 | GLU A 128LEU A 145LEU A 227 | None | 0.75A | 3ohtB-1r6xA:undetectable | 3ohtB-1r6xA:22.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rpn | GDP-MANNOSE4,6-DEHYDRATASE (Pseudomonasaeruginosa) |
PF16363(GDP_Man_Dehyd) | 3 | GLU A 128LEU A 286LEU A 305 | GDP A1601 (-3.7A)NoneNone | 0.77A | 3ohtB-1rpnA:undetectable | 3ohtB-1rpnA:23.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rt8 | FIMBRIN (Schizosaccharomycespombe) |
PF00307(CH) | 3 | GLU A 117LEU A 351LEU A 359 | None | 0.76A | 3ohtB-1rt8A:undetectable | 3ohtB-1rt8A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sv6 | 2-KETO-4-PENTENOATEHYDRATASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 3 | GLU A 138LEU A 229LEU A 201 | None | 0.61A | 3ohtB-1sv6A:undetectable | 3ohtB-1sv6A:20.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1taq | TAQ DNA POLYMERASE (Thermusaquaticus) |
PF00476(DNA_pol_A)PF01367(5_3_exonuc)PF02739(5_3_exonuc_N)PF09281(Taq-exonuc) | 3 | GLU A 434LEU A 379LEU A 412 | None | 0.70A | 3ohtB-1taqA:3.9 | 3ohtB-1taqA:20.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tdj | BIOSYNTHETICTHREONINE DEAMINASE (Escherichiacoli) |
PF00291(PALP)PF00585(Thr_dehydrat_C) | 3 | GLU A 308LEU A 310LEU A 174 | None | 0.62A | 3ohtB-1tdjA:undetectable | 3ohtB-1tdjA:22.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5u | ALLENE OXIDESYNTHASE-LIPOXYGENASE PROTEIN (Plexaurahomomalla) |
no annotation | 3 | GLU A 226LEU A 190LEU A 271 | None | 0.74A | 3ohtB-1u5uA:undetectable | 3ohtB-1u5uA:20.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ut9 | CELLULOSE1,4-BETA-CELLOBIOSIDASE (Ruminiclostridiumthermocellum) |
PF00759(Glyco_hydro_9)PF02927(CelD_N) | 3 | GLU A 406LEU A 629LEU A 634 | None | 0.65A | 3ohtB-1ut9A:undetectable | 3ohtB-1ut9A:20.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vhh | SONIC HEDGEHOG (Mus musculus) |
PF01085(HH_signal) | 3 | GLU A 54LEU A 140LEU A 107 | None | 0.64A | 3ohtB-1vhhA:undetectable | 3ohtB-1vhhA:17.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vkn | N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATEREDUCTASE (Thermotogamaritima) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | GLU A 128LEU A 152LEU A 269 | None | 0.77A | 3ohtB-1vknA:undetectable | 3ohtB-1vknA:24.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vli | SPORE COATPOLYSACCHARIDEBIOSYNTHESIS PROTEINSPSE (Bacillussubtilis) |
PF03102(NeuB)PF08666(SAF) | 3 | GLU A 163LEU A 136LEU A 343 | None | 0.78A | 3ohtB-1vliA:undetectable | 3ohtB-1vliA:22.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vzy | 33 KDA CHAPERONIN (Bacillussubtilis) |
PF01430(HSP33) | 3 | GLU A 199LEU A 204LEU A 170 | None | 0.66A | 3ohtB-1vzyA:undetectable | 3ohtB-1vzyA:22.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1x03 | SH3-CONTAININGGRB2-LIKE PROTEIN 2 (Homo sapiens) |
PF03114(BAR) | 3 | GLU A 162LEU A 166LEU A 187 | None | 0.54A | 3ohtB-1x03A:2.0 | 3ohtB-1x03A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xfb | ALDOLASE C (Homo sapiens) |
PF00274(Glycolytic) | 3 | GLU A 188LEU A 271LEU A 31 | None | 0.77A | 3ohtB-1xfbA:undetectable | 3ohtB-1xfbA:22.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zws | DAP-KINASE RELATEDPROTEIN 1 (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 64LEU A 91LEU A 95 | None | 0.67A | 3ohtB-1zwsA:6.4 | 3ohtB-1zwsA:28.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2a2a | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 64LEU A 91LEU A 95 | None | 0.53A | 3ohtB-2a2aA:3.2 | 3ohtB-2a2aA:28.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b2n | TRANSCRIPTION-REPAIRCOUPLING FACTOR (Escherichiacoli) |
no annotation | 3 | GLU A 304LEU A 300LEU A 76 | None | 0.76A | 3ohtB-2b2nA:undetectable | 3ohtB-2b2nA:24.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bd0 | SEPIAPTERINREDUCTASE (Chlorobaculumtepidum) |
PF00106(adh_short) | 3 | GLU A 33LEU A 59LEU A 20 | None | 0.70A | 3ohtB-2bd0A:undetectable | 3ohtB-2bd0A:20.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bdw | HYPOTHETICAL PROTEINK11E8.1D (Caenorhabditiselegans) |
PF00069(Pkinase) | 3 | GLU A 60LEU A 87LEU A 91 | None | 0.44A | 3ohtB-2bdwA:5.5 | 3ohtB-2bdwA:28.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bnh | RIBONUCLEASEINHIBITOR (Sus scrofa) |
PF13516(LRR_6) | 3 | GLU A 294LEU A 298LEU A 330 | None | 0.62A | 3ohtB-2bnhA:undetectable | 3ohtB-2bnhA:22.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c08 | SH3-CONTAININGGRB2-LIKE PROTEIN 2 (Rattusnorvegicus) |
PF03114(BAR) | 3 | GLU A 162LEU A 166LEU A 187 | None | 0.46A | 3ohtB-2c08A:2.1 | 3ohtB-2c08A:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2csn | CASEIN KINASE-1 (Schizosaccharomycespombe) |
PF00069(Pkinase) | 3 | GLU A 55LEU A 83LEU A 87 | None | 0.76A | 3ohtB-2csnA:4.0 | 3ohtB-2csnA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2det | TRNA-SPECIFIC2-THIOURIDYLASE MNMA (Escherichiacoli) |
PF03054(tRNA_Me_trans) | 3 | GLU A 352LEU A 142LEU A 173 | None | 0.73A | 3ohtB-2detA:undetectable | 3ohtB-2detA:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e2a | PROTEIN (ENZYME IIA) (Lactococcuslactis) |
PF02255(PTS_IIA) | 3 | GLU A 12LEU A 8LEU A 70 | None | 0.53A | 3ohtB-2e2aA:2.7 | 3ohtB-2e2aA:14.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2eb5 | 2-OXO-HEPT-3-ENE-1,7-DIOATE HYDRATASE (Escherichiacoli) |
PF01557(FAA_hydrolase) | 3 | GLU A 139LEU A 236LEU A 208 | MG A1001 ( 3.0A)NoneNone | 0.72A | 3ohtB-2eb5A:undetectable | 3ohtB-2eb5A:22.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ery | RAS-RELATED PROTEINR-RAS2 (Homo sapiens) |
PF00071(Ras) | 3 | GLU A 48LEU A 67LEU A 91 | None | 0.73A | 3ohtB-2eryA:undetectable | 3ohtB-2eryA:17.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f1s | VIRAL CASP8 ANDFADD-LIKE APOPTOSISREGULATOR (Molluscumcontagiosumvirus) |
PF01335(DED) | 3 | GLU A 105LEU A 27LEU A 72 | None | 0.69A | 3ohtB-2f1sA:undetectable | 3ohtB-2f1sA:18.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2f42 | STIP1 HOMOLOGY ANDU-BOX CONTAININGPROTEIN 1 (Danio rerio) |
PF04564(U-box) | 3 | GLU A 239LEU A 261LEU A 265 | None | 0.75A | 3ohtB-2f42A:3.5 | 3ohtB-2f42A:20.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fn4 | RAS-RELATED PROTEINR-RAS (Homo sapiens) |
PF00071(Ras) | 3 | GLU A 63LEU A 82LEU A 45 | None | 0.77A | 3ohtB-2fn4A:undetectable | 3ohtB-2fn4A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fn4 | RAS-RELATED PROTEINR-RAS (Homo sapiens) |
PF00071(Ras) | 3 | GLU A 63LEU A 82LEU A 106 | None | 0.65A | 3ohtB-2fn4A:undetectable | 3ohtB-2fn4A:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr2 | HYPOTHETICAL PROTEINRV2717C (Mycobacteriumtuberculosis) |
PF08768(DUF1794) | 3 | GLU A 67LEU A 83LEU A 118 | None | 0.53A | 3ohtB-2fr2A:undetectable | 3ohtB-2fr2A:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fuq | HEPARINASE IIPROTEIN (Pedobacterheparinus) |
PF07940(Hepar_II_III)PF16332(DUF4962) | 3 | GLU A 651LEU A 647LEU A 422 | None | 0.72A | 3ohtB-2fuqA:2.7 | 3ohtB-2fuqA:19.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2gq3 | MALATE SYNTHASE G (Mycobacteriumtuberculosis) |
PF01274(Malate_synthase) | 3 | GLU A 597LEU A 643LEU A 698 | None | 0.74A | 3ohtB-2gq3A:undetectable | 3ohtB-2gq3A:21.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hqy | CONSERVEDHYPOTHETICAL PROTEIN (Bacteroidesthetaiotaomicron) |
PF09924(DUF2156) | 3 | GLU A 172LEU A 194LEU A 40 | None | 0.63A | 3ohtB-2hqyA:undetectable | 3ohtB-2hqyA:21.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hxv | DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE/5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACILREDUCTASE (Thermotogamaritima) |
PF00383(dCMP_cyt_deam_1)PF01872(RibD_C) | 3 | GLU A 39LEU A 12LEU A 128 | None | 0.61A | 3ohtB-2hxvA:undetectable | 3ohtB-2hxvA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ibg | PROTEIN HEDGEHOG (Drosophilamelanogaster) |
PF01085(HH_signal) | 3 | GLU E 113LEU E 199LEU E 166 | None | 0.68A | 3ohtB-2ibgE:undetectable | 3ohtB-2ibgE:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ilr | FANCONI ANEMIA GROUPE PROTEIN (Homo sapiens) |
PF11510(FA_FANCE) | 3 | GLU A 506LEU A 510LEU A 476 | None | 0.59A | 3ohtB-2ilrA:undetectable | 3ohtB-2ilrA:19.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2n9v | DERMONECROTIC TOXIN (Pasteurellamultocida) |
PF11647(MLD) | 3 | GLU A 42LEU A 40LEU A 50 | None | 0.74A | 3ohtB-2n9vA:undetectable | 3ohtB-2n9vA:12.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2noq | 60S RIBOSOMALPROTEIN L11-B (Saccharomycescerevisiae) |
PF00281(Ribosomal_L5)PF00673(Ribosomal_L5_C) | 3 | GLU H 87LEU H 83LEU H 18 | None | 0.72A | 3ohtB-2noqH:undetectable | 3ohtB-2noqH:18.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nt8 | COBALAMINADENOSYLTRANSFERASE (Lactobacillusreuteri) |
PF01923(Cob_adeno_trans) | 3 | GLU A 135LEU A 152LEU A 65 | None | 0.78A | 3ohtB-2nt8A:undetectable | 3ohtB-2nt8A:22.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nxx | ECDYSONE RECEPTOR(ECR, NRH1) (Triboliumcastaneum) |
PF00104(Hormone_recep) | 3 | GLU E 473LEU E 383LEU E 391 | None | 0.77A | 3ohtB-2nxxE:undetectable | 3ohtB-2nxxE:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ocp | DEOXYGUANOSINEKINASE (Homo sapiens) |
PF01712(dNK) | 3 | GLU A 211LEU A 203LEU A 192 | DTP A 301 (-3.5A)NoneNone | 0.65A | 3ohtB-2ocpA:undetectable | 3ohtB-2ocpA:21.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oi6 | BIFUNCTIONAL PROTEINGLMU (Escherichiacoli) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 3 | GLU A 236LEU A 30LEU A 23 | None | 0.69A | 3ohtB-2oi6A:undetectable | 3ohtB-2oi6A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pyj | DNA POLYMERASE (Bacillus virusphi29) |
PF03175(DNA_pol_B_2) | 3 | GLU A 221LEU A 351LEU A 333 | NoneNoneEDO A2771 (-4.8A) | 0.65A | 3ohtB-2pyjA:undetectable | 3ohtB-2pyjA:21.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qb0 | TELSAM DOMAIN -LYSOZYME CHIMERA (Escherichiavirus T4) |
PF00959(Phage_lysozyme)PF02198(SAM_PNT) | 3 | GLU B 157LEU B 24LEU B 62 | MN B 257 (-2.9A)NoneNone | 0.74A | 3ohtB-2qb0B:2.2 | 3ohtB-2qb0B:23.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r1i | GCN5-RELATEDN-ACETYLTRANSFERASE (Arthrobactersp. FB24) |
PF00583(Acetyltransf_1) | 3 | GLU A 134LEU A 132LEU A 124 | NoneGOL A 177 (-4.3A)None | 0.75A | 3ohtB-2r1iA:undetectable | 3ohtB-2r1iA:16.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2reb | REC A (Escherichiacoli) |
PF00154(RecA) | 3 | GLU A 154LEU A 166LEU A 126 | None | 0.76A | 3ohtB-2rebA:undetectable | 3ohtB-2rebA:22.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rjb | UNCHARACTERIZEDPROTEIN (Shigellaflexneri) |
PF07063(DUF1338) | 3 | GLU A 272LEU A 270LEU A 225 | None | 0.73A | 3ohtB-2rjbA:undetectable | 3ohtB-2rjbA:24.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w4k | DEATH-ASSOCIATEDPROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 64LEU A 91LEU A 95 | ADP A1303 ( 4.8A)NoneNone | 0.49A | 3ohtB-2w4kA:5.0 | 3ohtB-2w4kA:27.89 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wnt | RIBOSOMAL PROTEIN S6KINASE (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 459LEU A 487LEU A 491 | None | 0.71A | 3ohtB-2wntA:5.6 | 3ohtB-2wntA:30.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2woc | ADP-RIBOSYL-[DINITROGEN REDUCTASE]GLYCOHYDROLASE (Rhodospirillumrubrum) |
PF03747(ADP_ribosyl_GH) | 3 | GLU A 277LEU A 15LEU A 23 | None | 0.60A | 3ohtB-2wocA:undetectable | 3ohtB-2wocA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y3a | PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE3-KINASE CATALYTICSUBUNIT BETA ISOFORM (Mus musculus) |
PF00454(PI3_PI4_kinase)PF00613(PI3Ka)PF00792(PI3K_C2)PF00794(PI3K_rbd)PF02192(PI3K_p85B) | 3 | GLU A1029LEU A1032LEU A1022 | None | 0.77A | 3ohtB-2y3aA:2.5 | 3ohtB-2y3aA:16.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yab | DEATH-ASSOCIATEDPROTEIN KINASE 2 (Mus musculus) |
PF00069(Pkinase) | 3 | GLU A 64LEU A 91LEU A 95 | NoneNoneAMP A1302 ( 4.9A) | 0.52A | 3ohtB-2yabA:5.5 | 3ohtB-2yabA:27.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ywb | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Thermusthermophilus) |
PF00117(GATase)PF00958(GMP_synt_C) | 3 | GLU A 361LEU A 365LEU A 377 | None | 0.73A | 3ohtB-2ywbA:2.0 | 3ohtB-2ywbA:21.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2zc0 | ALANINE GLYOXYLATETRANSAMINASE (Thermococcuslitoralis) |
PF00155(Aminotran_1_2) | 3 | GLU A 79LEU A 288LEU A 62 | None | 0.71A | 3ohtB-2zc0A:undetectable | 3ohtB-2zc0A:22.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3asm | RIBONUCLEASE HIII (Geobacillusstearothermophilus) |
PF01351(RNase_HII)PF11858(DUF3378) | 3 | GLU A 74LEU A 52LEU A 33 | None | 0.71A | 3ohtB-3asmA:undetectable | 3ohtB-3asmA:20.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bc1 | RAS-RELATED PROTEINRAB-27A (Mus musculus) |
PF00071(Ras) | 3 | GLU A 161LEU A 101LEU A 108 | None | 0.70A | 3ohtB-3bc1A:undetectable | 3ohtB-3bc1A:20.28 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bhh | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE TYPE II BETACHAIN (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 61LEU A 88LEU A 92 | NoneNone5CP A 600 (-4.6A) | 0.65A | 3ohtB-3bhhA:5.8 | 3ohtB-3bhhA:28.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bv4 | FRUCTOSE-BISPHOSPHATE ALDOLASE A (Oryctolaguscuniculus) |
PF00274(Glycolytic) | 3 | GLU A 187LEU A 270LEU A 30 | None13P A3371 (-3.8A)None | 0.77A | 3ohtB-3bv4A:undetectable | 3ohtB-3bv4A:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bvh | FIBRINOGEN BETACHAIN (Homo sapiens) |
PF00147(Fibrinogen_C)PF08702(Fib_alpha) | 3 | GLU B 313LEU B 311LEU B 294 | None | 0.75A | 3ohtB-3bvhB:undetectable | 3ohtB-3bvhB:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3clm | TRANSALDOLASE (Neisseriagonorrhoeae) |
PF00923(TAL_FSA) | 3 | GLU A 122LEU A 112LEU A 163 | None | 0.48A | 3ohtB-3clmA:undetectable | 3ohtB-3clmA:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cpf | EUKARYOTICTRANSLATIONINITIATION FACTOR5A-1 (Homo sapiens) |
PF01287(eIF-5a) | 3 | GLU A 144LEU A 112LEU A 134 | UNX A 5 (-3.9A)UNX A 1 (-4.1A)None | 0.76A | 3ohtB-3cpfA:undetectable | 3ohtB-3cpfA:17.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmk | DOWN SYNDROME CELLADHESION MOLECULE(DSCAM) ISOFORM1.30.30, N-TERMINALEIGHT IG DOMAINS (Drosophilamelanogaster) |
PF07679(I-set)PF13927(Ig_3) | 3 | GLU A 165LEU A 234LEU A 217 | None | 0.78A | 3ohtB-3dmkA:undetectable | 3ohtB-3dmkA:19.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dzd | TRANSCRIPTIONALREGULATOR (NTRCFAMILY) (Aquifexaeolicus) |
PF00072(Response_reg)PF00158(Sigma54_activat) | 3 | GLU A 135LEU A 140LEU A 299 | None | 0.73A | 3ohtB-3dzdA:undetectable | 3ohtB-3dzdA:24.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e10 | PUTATIVE NADHOXIDASE (Clostridiumacetobutylicum) |
PF00881(Nitroreductase) | 3 | GLU A 97LEU A 101LEU A 27 | None | 0.77A | 3ohtB-3e10A:undetectable | 3ohtB-3e10A:17.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e2s | PROLINEDEHYDROGENASE (Escherichiacoli) |
PF01619(Pro_dh)PF14850(Pro_dh-DNA_bdg) | 3 | GLU A 385LEU A 420LEU A 412 | None | 0.73A | 3ohtB-3e2sA:undetectable | 3ohtB-3e2sA:19.90 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3e7o | MITOGEN-ACTIVATEDPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 73LEU A 106LEU A 110 | NoneNone35F A 1 (-4.5A) | 0.42A | 3ohtB-3e7oA:8.1 | 3ohtB-3e7oA:46.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ek1 | ALDEHYDEDEHYDROGENASE (Brucellaabortus) |
PF00171(Aldedh) | 3 | GLU A 198LEU A 15LEU A 188 | None | 0.66A | 3ohtB-3ek1A:undetectable | 3ohtB-3ek1A:22.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ek3 | NITROREDUCTASE (Bacteroidesfragilis) |
PF00881(Nitroreductase) | 3 | GLU A 117LEU A 121LEU A 33 | None | 0.62A | 3ohtB-3ek3A:undetectable | 3ohtB-3ek3A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3esl | CHECKPOINTSERINE/THREONINE-PROTEIN KINASE BUB1 (Saccharomycescerevisiae) |
PF08311(Mad3_BUB1_I) | 3 | GLU A 198LEU A 160LEU A 168 | None | 0.69A | 3ohtB-3eslA:undetectable | 3ohtB-3eslA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3euc | HISTIDINOL-PHOSPHATEAMINOTRANSFERASE 2 (Cupriaviduspinatubonensis) |
PF00155(Aminotran_1_2) | 3 | GLU A 269LEU A 265LEU A 229 | None | 0.78A | 3ohtB-3eucA:undetectable | 3ohtB-3eucA:20.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f2i | ALR0221 PROTEIN (Nostoc sp. PCC7120) |
PF00300(His_Phos_1) | 3 | GLU A 75LEU A 49LEU A 5 | None | 0.64A | 3ohtB-3f2iA:undetectable | 3ohtB-3f2iA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fok | UNCHARACTERIZEDPROTEIN CGL0159 (Corynebacteriumglutamicum) |
no annotation | 3 | GLU A 182LEU A 243LEU A 44 | None | 0.71A | 3ohtB-3fokA:undetectable | 3ohtB-3fokA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fww | BIFUNCTIONAL PROTEINGLMU (Yersinia pestis) |
PF00132(Hexapep)PF12804(NTP_transf_3) | 3 | GLU A 236LEU A 30LEU A 23 | None | 0.69A | 3ohtB-3fwwA:undetectable | 3ohtB-3fwwA:22.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fyd | PROBABLEDIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 3 | GLU A 36LEU A 48LEU A 74 | None | 0.61A | 3ohtB-3fydA:undetectable | 3ohtB-3fydA:20.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g5a | FMNADENYLYLTRANSFERASE ([Candida]glabrata) |
PF01507(PAPS_reduct) | 3 | GLU A 210LEU A 9LEU A 78 | None | 0.75A | 3ohtB-3g5aA:undetectable | 3ohtB-3g5aA:22.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gd5 | ORNITHINECARBAMOYLTRANSFERASE (Gloeobacterviolaceus) |
PF00185(OTCace)PF02729(OTCace_N) | 3 | GLU A 150LEU A 146LEU A 160 | None | 0.75A | 3ohtB-3gd5A:undetectable | 3ohtB-3gd5A:21.36 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3gp0 | MITOGEN-ACTIVATEDPROTEIN KINASE 11 (Homo sapiens) |
PF00069(Pkinase) | 3 | GLU A 71LEU A 104LEU A 108 | NIL A 1 (-3.7A)NIL A 1 ( 4.3A)NIL A 1 ( 4.4A) | 0.33A | 3ohtB-3gp0A:32.9 | 3ohtB-3gp0A:68.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gry | DIMETHYLADENOSINETRANSFERASE (Methanocaldococcusjannaschii) |
PF00398(RrnaAD) | 3 | GLU A 36LEU A 48LEU A 74 | SAM A 300 (-4.4A)NoneNone | 0.62A | 3ohtB-3gryA:undetectable | 3ohtB-3gryA:22.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h2z | MANNITOL-1-PHOSPHATE5-DEHYDROGENASE (Shigellaflexneri) |
PF01232(Mannitol_dh)PF08125(Mannitol_dh_C) | 3 | GLU A 282LEU A 240LEU A 226 | None | 0.73A | 3ohtB-3h2zA:undetectable | 3ohtB-3h2zA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3h92 | UNCHARACTERIZEDATP-BINDING PROTEINMJECL15 (Methanocaldococcusjannaschii) |
no annotation | 3 | GLU A 65LEU A 20LEU A 83 | None | 0.74A | 3ohtB-3h92A:undetectable | 3ohtB-3h92A:15.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hba | PUTATIVEPHOSPHOSUGARISOMERASE (Shewanelladenitrificans) |
PF01380(SIS) | 3 | GLU A 227LEU A 223LEU A 256 | None | 0.77A | 3ohtB-3hbaA:undetectable | 3ohtB-3hbaA:21.14 |