SIMILAR PATTERNS OF AMINO ACIDS FOR 3OHT_B_1N1B1000_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
LEU A  78
ILE A  87
GLY A 113
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
None
ANP  A 400 (-4.9A)
None
ANP  A 400 (-4.0A)
 0.80A 3ohtB-1cm8A:
6.2		 3ohtB-1cm8A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
LYS A  56
LEU A  78
ILE A  87
GLY A 113
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
ANP  A 400 (-4.9A)
None
 0.66A 3ohtB-1cm8A:
6.2		 3ohtB-1cm8A:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 272
 None
 0.91A 3ohtB-1k9aA:
16.9		 3ohtB-1k9aA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.91A 3ohtB-1k9aA:
16.9		 3ohtB-1k9aA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A 165
VAL A 172
ALA A 185
LYS A 187
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 1.15A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A 165
VAL A 172
LYS A 187
LEU A 206
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
 1.27A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 596
VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
GLY A 676
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
 0.70A 3ohtB-1t46A:
16.2		 3ohtB-1t46A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
 None
 0.54A 3ohtB-1u5qA:
17.8		 3ohtB-1u5qA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LEU A  68
ILE A  77
 None
 0.50A 3ohtB-1zwsA:
6.4		 3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  18
VAL X  25
ALA X  37
LYS X  39
THR X  82
GLY X  88
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
 0.82A 3ohtB-2dq7X:
17.3		 3ohtB-2dq7X:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
ILE A  72
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
 1.00A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  63
ILE A  72
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.68A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
GLY A 110
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-3.4A)
 0.64A 3ohtB-2gcdA:
18.4		 3ohtB-2gcdA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 636
VAL A 643
ALA A 659
ILE A 691
THR A 707
LEU A 761
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
 0.94A 3ohtB-2henA:
17.4		 3ohtB-2henA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 252
VAL A 259
ALA A 271
LYS A 273
THR A 316
LEU A 371
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.84A 3ohtB-2hk5A:
17.1		 3ohtB-2hk5A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 249
VAL A 256
ALA A 269
LYS A 271
THR A 315
GLY A 321
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
 0.71A 3ohtB-2hz0A:
16.6		 3ohtB-2hz0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 349
VAL A 356
ALA A 369
LYS A 371
LEU A 394
 PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
 0.42A 3ohtB-2i0eA:
4.8		 3ohtB-2i0eA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
ALA A  46
LYS A  48
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.87A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
LYS A  48
LEU A  77
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.93A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A 429
ALA A 449
LYS A 451
LEU A 467
ILE A 477
THR A 493
 None
 0.58A 3ohtB-2qr7A:
5.4		 3ohtB-2qr7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 682
VAL A 689
ALA A 705
ILE A 737
THR A 753
GLY A 759
 None
 1.15A 3ohtB-2r2pA:
17.5		 3ohtB-2r2pA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
 0.50A 3ohtB-2w4kA:
5.0		 3ohtB-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY C  56
VAL C  63
ALA C  76
LYS C  78
ILE C 111
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
 0.53A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  56
VAL C  63
LYS C  78
LEU C 102
ILE C 111
GLY C 135
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 1.42A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 628
VAL A 635
ALA A 651
LYS A 653
ILE A 683
THR A 699
LEU A 753
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
 0.92A 3ohtB-2xyuA:
6.0		 3ohtB-2xyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 628
VAL A 635
ALA A 651
LYS A 653
THR A 699
GLY A 705
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
 0.79A 3ohtB-2xyuA:
6.0		 3ohtB-2xyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A  81
GLY A 113
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
 0.91A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
LEU A  81
ILE A  91
GLY A 113
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
B49  A1294 (-3.6A)
 0.94A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
 0.46A 3ohtB-2yabA:
5.5		 3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
4RB  A 401 ( 4.3A)
 0.61A 3ohtB-3bqrA:
18.6		 3ohtB-3bqrA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
LEU A  76
ILE A  85
LEU A 167
 None
 0.43A 3ohtB-3coiA:
32.6		 3ohtB-3coiA:
58.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 272
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
VAL A 158
ALA A 169
LYS A 171
ILE A 204
GLY A 226
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
 0.93A 3ohtB-3dtcA:
5.1		 3ohtB-3dtcA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  33
VAL A  40
ALA A  53
LYS A  55
LEU A  77
 35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
 0.53A 3ohtB-3e7oA:
8.1		 3ohtB-3e7oA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.69A 3ohtB-3f2aA:
5.1		 3ohtB-3f2aA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
ASN A 114
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
 1.20A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
 0.73A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  31
VAL A  38
ALA A  51
LYS A  53
ILE A  84
THR A 106
ASN A 115
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
 1.02A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
LYS A 667
ILE A 697
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.89A 3ohtB-3kulA:
17.0		 3ohtB-3kulA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 681
VAL A 689
ALA A 700
LYS A 702
LEU A 719
ILE A 729
 ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
 0.68A 3ohtB-3lj0A:
3.2		 3ohtB-3lj0A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A 559
VAL A 566
ALA A 579
LYS A 581
LEU A 600
GLY A 634
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.61A 3ohtB-3lltA:
5.3		 3ohtB-3lltA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  40
VAL A  47
ALA A  60
LEU A  84
ILE A  94
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 0.51A 3ohtB-3lm5A:
6.9		 3ohtB-3lm5A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 GLY A 211
VAL A 218
ALA A 229
LYS A 231
THR A 279
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.50A 3ohtB-3mdyA:
15.4		 3ohtB-3mdyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
VAL A  57
ALA A  70
LYS A  72
LEU A  95
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.49A 3ohtB-3mvjA:
5.3		 3ohtB-3mvjA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
VAL A 216
ALA A 227
LYS A 229
THR A 277
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
 0.88A 3ohtB-3my0A:
4.5		 3ohtB-3my0A:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  79
ILE A  88
 None
None
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
None
None
 0.63A 3ohtB-3n9xA:
26.2		 3ohtB-3n9xA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  37
VAL A  44
ALA A  57
LYS A  59
LEU A  81
 ANP  A 430 (-3.5A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
None
 0.52A 3ohtB-3nieA:
26.9		 3ohtB-3nieA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A  44
ALA A  57
LYS A  59
LEU A  81
ILE A  90
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
None
ANP  A 430 ( 4.5A)
 0.48A 3ohtB-3nieA:
26.9		 3ohtB-3nieA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 VAL A  37
ALA A  49
LYS A  51
LEU A  82
THR A 112
 None
 0.42A 3ohtB-3pg1A:
7.3		 3ohtB-3pg1A:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 0.75A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 852
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.4A)
 0.94A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLY A 558
VAL A 565
ALA A 576
LYS A 578
THR A 625
GLY A 631
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.90A 3ohtB-3ppzA:
17.1		 3ohtB-3ppzA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  64
VAL A  71
ALA A  84
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
 0.46A 3ohtB-3q5iA:
3.9		 3ohtB-3q5iA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 362
VAL A 369
ALA A 382
LYS A 384
LEU A 407
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.51A 3ohtB-3txoA:
5.1		 3ohtB-3txoA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
GLY A 703
 None
 0.84A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
LEU A 751
 None
 0.95A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
GLY A 175
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
 0.97A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.98A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
LYS A 123
ILE A 153
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
 1.01A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.84A 3ohtB-4c02A:
4.5		 3ohtB-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 GLY A 247
VAL A 254
ALA A 267
LYS A 269
LEU A 292
ILE A 302
 None
 0.71A 3ohtB-4c0tA:
5.6		 3ohtB-4c0tA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 617
VAL A 624
ALA A 653
LYS A 655
ILE A 685
THR A 701
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
 0.46A 3ohtB-4ckrA:
16.9		 3ohtB-4ckrA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  59
GLY A  92
 BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
 0.84A 3ohtB-4euuA:
2.5		 3ohtB-4euuA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
VAL A 836
ALA A 853
LYS A 855
LEU A 875
GLY A 908
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
 0.86A 3ohtB-4hviA:
16.8		 3ohtB-4hviA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 GLY A 133
VAL A 140
ALA A 156
THR A 205
GLY A 211
 None
 0.53A 3ohtB-4hzsA:
4.9		 3ohtB-4hzsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 133
VAL A 140
ALA A 156
ILE A 190
THR A 205
GLY A 211
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
 1.12A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 133
VAL A 140
ALA A 156
LYS A 158
ILE A 190
THR A 205
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
 0.68A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 479
VAL A 486
ALA A 506
LYS A 508
ILE A 539
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
 0.51A 3ohtB-4k33A:
5.4		 3ohtB-4k33A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  31
VAL B  38
ALA B  51
LYS B  53
LEU B  74
GLY B 103
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
 0.73A 3ohtB-4o27B:
5.9		 3ohtB-4o27B:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 620
VAL A 627
ALA A 644
ILE A 676
THR A 692
LEU A 746
 None
 0.96A 3ohtB-4p2kA:
6.1		 3ohtB-4p2kA:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 VAL A  35
ALA A  49
LYS A  51
LEU A  74
ILE A  83
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
None
ANP  A 402 (-4.8A)
 0.47A 3ohtB-4qnyA:
9.0		 3ohtB-4qnyA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 167
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.77A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
LEU B  75
ILE B  84
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
 0.45A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ASN B 115
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 0.85A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
 None
 0.49A 3ohtB-4xi2A:
6.1		 3ohtB-4xi2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
 0.53A 3ohtB-4y93A:
5.3		 3ohtB-4y93A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 470
VAL A 477
ALA A 488
LYS A 490
LEU A 513
ILE A 522
THR A 539
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
 0.63A 3ohtB-4yffA:
5.9		 3ohtB-4yffA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
 0.68A 3ohtB-4ysjA:
18.7		 3ohtB-4ysjA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A  73
GLY A 111
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
GLY  A 111 (-0.0A)
 0.69A 3ohtB-5d7aA:
18.3		 3ohtB-5d7aA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 251
VAL A 258
ALA A 275
LYS A 277
THR A 325
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.9A)
 0.96A 3ohtB-5e8yA:
4.6		 3ohtB-5e8yA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
 0.42A 3ohtB-5ezrA:
4.9		 3ohtB-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 464
VAL A 471
ALA A 481
LYS A 483
THR A 529
 None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.4A)
 0.50A 3ohtB-5fd2A:
17.1		 3ohtB-5fd2A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
 0.85A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 779
ILE A 788
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
 0.59A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
GLY A 680
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.76A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
THR A 674
GLY A 680
ASN A 684
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
None
 0.81A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
ALA A  43
LYS A  45
ILE A  66
THR A  82
GLY A  88
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
 0.88A 3ohtB-5hesA:
4.7		 3ohtB-5hesA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 156
VAL A 163
ALA A 176
LYS A 178
ILE A 212
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
 0.46A 3ohtB-5lxdA:
8.8		 3ohtB-5lxdA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 GLY A  18
VAL A  25
ALA A  38
LYS A  40
LEU A  61
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
 0.52A 3ohtB-5tvtA:
6.4		 3ohtB-5tvtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 117
VAL A 124
ALA A 137
LYS A 139
THR A 187
 H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
 0.49A 3ohtB-5vcxA:
18.0		 3ohtB-5vcxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
 0.83A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
LEU A1017
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.99A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 GLY A 216
VAL A 223
ALA A 236
LYS A 238
ILE A 272
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.8A)
 0.51A 3ohtB-5y86A:
7.4		 3ohtB-5y86A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 GLY A 532
VAL A 539
ALA A 551
LYS A 553
LEU A 575
ILE A 586
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
CQ7  A 801 ( 4.5A)
 0.80A 3ohtB-6b4wA:
5.4		 3ohtB-6b4wA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 GLY A 172
VAL A 179
ALA A 192
LYS A 194
LEU A 240
GLY A 273
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
None
F6J  A 501 ( 3.7A)
 0.75A 3ohtB-6cmjA:
6.5		 3ohtB-6cmjA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 3.8A)
 0.78A 3ohtB-6fekA:
16.6		 3ohtB-6fekA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 GLY A 170
VAL A 177
ALA A 191
LYS A 193
LEU A 212
GLY A 247
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
 0.72A 3ohtB-6fylA:
5.0		 3ohtB-6fylA:
undetectable