SIMILAR PATTERNS OF AMINO ACIDS FOR 3OHT_B_1N1B1000

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
LEU A  78
ILE A  87
GLY A 113
LEU A 170
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
None
ANP  A 400 (-4.9A)
None
ANP  A 400 (-4.0A)
 0.80A 3ohtB-1cm8A:
6.2		 3ohtB-1cm8A:
58.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cm8 PHOSPHORYLATED MAP
KINASE P38-GAMMA

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  41
ALA A  54
LYS A  56
LEU A  78
ILE A  87
GLY A 113
 ANP  A 400 (-4.1A)
ANP  A 400 (-3.3A)
ANP  A 400 (-2.9A)
None
ANP  A 400 (-4.9A)
None
 0.66A 3ohtB-1cm8A:
6.2		 3ohtB-1cm8A:
58.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 272
 None
 0.91A 3ohtB-1k9aA:
16.9		 3ohtB-1k9aA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.91A 3ohtB-1k9aA:
16.9		 3ohtB-1k9aA:
23.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A 165
VAL A 172
ALA A 185
LYS A 187
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
 1.15A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A 165
VAL A 172
LYS A 187
LEU A 206
GLY A 250
LEU A 226
 ADP  A 810 (-3.3A)
ADP  A 810 (-4.1A)
ADP  A 810 (-3.1A)
None
None
ADP  A 810 (-4.4A)
 1.27A 3ohtB-1q8yA:
5.7		 3ohtB-1q8yA:
27.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 596
VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
GLY A 676
 None
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
STI  A   3 ( 3.8A)
 0.70A 3ohtB-1t46A:
16.2		 3ohtB-1t46A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 GLY A  35
VAL A  42
ALA A  55
LYS A  57
ILE A  89
 None
 0.54A 3ohtB-1u5qA:
17.8		 3ohtB-1u5qA:
27.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LEU A  68
ILE A  77
 None
 0.50A 3ohtB-1zwsA:
6.4		 3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY X  18
VAL X  25
ALA X  37
LYS X  39
THR X  82
GLY X  88
 STU  X 902 ( 3.7A)
STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 (-4.1A)
STU  X 902 (-3.5A)
 0.82A 3ohtB-2dq7X:
17.3		 3ohtB-2dq7X:
27.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
ILE A  72
LEU A 144
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
ADP  A 500 (-4.3A)
 1.00A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2f9g MITOGEN-ACTIVATED
PROTEIN KINASE FUS3

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  63
ILE A  72
 ADP  A 500 ( 4.1A)
ADP  A 500 (-4.3A)
ADP  A 500 ( 3.7A)
ADP  A 500 (-2.9A)
None
None
 0.68A 3ohtB-2f9gA:
28.7		 3ohtB-2f9gA:
41.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
GLY A 110
 STU  A 400 (-3.3A)
STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 (-3.4A)
 0.64A 3ohtB-2gcdA:
18.4		 3ohtB-2gcdA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 636
VAL A 643
ALA A 659
ILE A 691
THR A 707
LEU A 761
 ADP  A 400 ( 3.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
 0.94A 3ohtB-2henA:
17.4		 3ohtB-2henA:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 252
VAL A 259
ALA A 271
LYS A 273
THR A 316
LEU A 371
 None
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.84A 3ohtB-2hk5A:
17.1		 3ohtB-2hk5A:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 249
VAL A 256
ALA A 269
LYS A 271
THR A 315
GLY A 321
 None
GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.4A)
None
 0.71A 3ohtB-2hz0A:
16.6		 3ohtB-2hz0A:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 349
VAL A 356
ALA A 369
LYS A 371
LEU A 394
 PDS  A 901 ( 3.7A)
PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
 0.42A 3ohtB-2i0eA:
4.8		 3ohtB-2i0eA:
25.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
ALA A  46
LYS A  48
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
 0.87A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		6 GLY A  26
VAL A  33
LYS A  48
LEU A  77
ILE A  87
GLY A 109
 ATP  A 381 (-3.5A)
ATP  A 381 (-4.1A)
ATP  A 381 (-3.2A)
None
None
None
 0.93A 3ohtB-2phkA:
18.1		 3ohtB-2phkA:
30.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qr7 RIBOSOMAL PROTEIN S6
KINASE ALPHA-3

(Mus musculus) 		PF00069
(Pkinase) 		6 GLY A 429
ALA A 449
LYS A 451
LEU A 467
ILE A 477
THR A 493
 None
 0.58A 3ohtB-2qr7A:
5.4		 3ohtB-2qr7A:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 682
VAL A 689
ALA A 705
ILE A 737
THR A 753
GLY A 759
 None
 1.15A 3ohtB-2r2pA:
17.5		 3ohtB-2r2pA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 ADP  A1303 (-3.4A)
ADP  A1303 (-4.0A)
ADP  A1303 (-3.5A)
ADP  A1303 (-2.7A)
None
 0.50A 3ohtB-2w4kA:
5.0		 3ohtB-2w4kA:
27.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY C  56
VAL C  63
ALA C  76
LYS C  78
ILE C 111
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.4A)
ANP  C   2 (-3.6A)
None
 0.53A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY C  56
VAL C  63
LYS C  78
LEU C 102
ILE C 111
GLY C 135
 ANP  C   2 (-3.3A)
ANP  C   2 (-4.2A)
ANP  C   2 (-3.6A)
None
None
None
 1.42A 3ohtB-2wtkC:
18.0		 3ohtB-2wtkC:
24.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 GLY A 628
VAL A 635
ALA A 651
LYS A 653
ILE A 683
THR A 699
LEU A 753
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.3A)
 0.92A 3ohtB-2xyuA:
6.0		 3ohtB-2xyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		6 GLY A 628
VAL A 635
ALA A 651
LYS A 653
THR A 699
GLY A 705
 None
Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.5A)
Q9G  A1898 ( 3.8A)
 0.79A 3ohtB-2xyuA:
6.0		 3ohtB-2xyuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  31
VAL A  38
ALA A  51
LYS A  53
LEU A  81
GLY A 113
 B49  A1294 (-4.0A)
None
B49  A1294 (-3.2A)
None
None
B49  A1294 (-3.6A)
 0.91A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		6 VAL A  38
ALA A  51
LYS A  53
LEU A  81
ILE A  91
GLY A 113
 None
B49  A1294 (-3.2A)
None
None
B49  A1294 ( 4.6A)
B49  A1294 (-3.6A)
 0.94A 3ohtB-2y7jA:
19.5		 3ohtB-2y7jA:
25.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		5 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
 AMP  A1302 (-3.5A)
AMP  A1302 (-4.2A)
AMP  A1302 (-3.6A)
AMP  A1302 (-2.8A)
None
 0.46A 3ohtB-2yabA:
5.5		 3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqr DEATH-ASSOCIATED
PROTEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  20
VAL A  27
ALA A  40
LYS A  42
LEU A  68
ILE A  77
 4RB  A 401 (-3.6A)
4RB  A 401 ( 4.4A)
4RB  A 401 (-3.3A)
4RB  A 401 ( 2.8A)
None
4RB  A 401 ( 4.3A)
 0.61A 3ohtB-3bqrA:
18.6		 3ohtB-3bqrA:
25.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3coi MITOGEN-ACTIVATED
PROTEIN KINASE 13

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
LEU A  76
ILE A  85
LEU A 167
 None
 0.43A 3ohtB-3coiA:
32.6		 3ohtB-3coiA:
58.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 272
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 202
VAL A 209
ALA A 220
LYS A 222
THR A 266
LEU A 321
 None
 0.91A 3ohtB-3d7uA:
5.5		 3ohtB-3d7uA:
23.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dtc MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 9

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 151
VAL A 158
ALA A 169
LYS A 171
ILE A 204
GLY A 226
 VIN  A6331 (-3.5A)
VIN  A6331 (-4.7A)
VIN  A6331 (-3.4A)
None
VIN  A6331 ( 4.9A)
VIN  A6331 (-3.4A)
 0.93A 3ohtB-3dtcA:
5.1		 3ohtB-3dtcA:
25.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  33
VAL A  40
ALA A  53
LYS A  55
LEU A  77
 35F  A   1 ( 4.8A)
35F  A   1 ( 4.8A)
35F  A   1 (-3.6A)
35F  A   1 ( 4.6A)
None
 0.53A 3ohtB-3e7oA:
8.1		 3ohtB-3e7oA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2a PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE PIM-1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  45
VAL A  52
ALA A  65
LYS A  67
LEU A  93
ILE A 104
 985  A   1 ( 3.9A)
985  A   1 (-4.5A)
985  A   1 (-3.5A)
985  A   1 ( 2.8A)
MG  A 314 ( 4.8A)
985  A   1 ( 4.7A)
 0.69A 3ohtB-3f2aA:
5.1		 3ohtB-3f2aA:
23.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
ASN A 114
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
 1.20A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 GLY A  31
VAL A  38
ALA A  51
LEU A  75
ILE A  84
THR A 106
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
NIL  A   1 ( 4.8A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
NIL  A   1 (-4.0A)
 0.73A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		8 GLY A  31
VAL A  38
ALA A  51
LYS A  53
ILE A  84
THR A 106
ASN A 115
LEU A 167
 None
NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
NIL  A   1 (-4.0A)
 1.02A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 VAL A 649
ALA A 665
LYS A 667
ILE A 697
THR A 713
GLY A 719
 None
None
None
None
None
GOL  A 403 (-3.4A)
 0.89A 3ohtB-3kulA:
17.0		 3ohtB-3kulA:
26.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1

(Saccharomyces
cerevisiae) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A) 		6 GLY A 681
VAL A 689
ALA A 700
LYS A 702
LEU A 719
ILE A 729
 ADP  A2101 (-3.6A)
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
None
None
 0.68A 3ohtB-3lj0A:
3.2		 3ohtB-3lj0A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3llt SERINE/THREONINE
KINASE-1, PFLAMMER

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		6 GLY A 559
VAL A 566
ALA A 579
LYS A 581
LEU A 600
GLY A 634
 ANP  A 877 (-3.8A)
ANP  A 877 (-4.1A)
ANP  A 877 ( 3.7A)
ANP  A 877 (-2.7A)
None
None
 0.61A 3ohtB-3lltA:
5.3		 3ohtB-3lltA:
26.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  40
VAL A  47
ALA A  60
LEU A  84
ILE A  94
 None
QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 ( 4.6A)
QUE  A   1 (-4.6A)
 0.51A 3ohtB-3lm5A:
6.9		 3ohtB-3lm5A:
29.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		5 GLY A 211
VAL A 218
ALA A 229
LYS A 231
THR A 279
 LDN  A   1 ( 4.7A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
LDN  A   1 (-3.8A)
 0.50A 3ohtB-3mdyA:
15.4		 3ohtB-3mdyA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A  50
VAL A  57
ALA A  70
LYS A  72
LEU A  95
 XFE  A 351 ( 4.0A)
XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
 0.49A 3ohtB-3mvjA:
5.3		 3ohtB-3mvjA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 209
VAL A 216
ALA A 227
LYS A 229
THR A 277
LEU A 337
 None
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.6A)
 0.88A 3ohtB-3my0A:
4.5		 3ohtB-3my0A:
24.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3n9x PHOSPHOTRANSFERASE

(Plasmodium
berghei) 		PF00069
(Pkinase) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  79
ILE A  88
 None
None
GOL  A 434 ( 4.1A)
GOL  A 433 (-3.2A)
None
None
 0.63A 3ohtB-3n9xA:
26.2		 3ohtB-3n9xA:
32.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 GLY A  37
VAL A  44
ALA A  57
LYS A  59
LEU A  81
 ANP  A 430 (-3.5A)
ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
None
 0.52A 3ohtB-3nieA:
26.9		 3ohtB-3nieA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nie MAP2 KINASE

(Plasmodium
falciparum) 		PF00069
(Pkinase) 		5 VAL A  44
ALA A  57
LYS A  59
LEU A  81
ILE A  90
 ANP  A 430 (-4.2A)
ANP  A 430 (-3.5A)
ANP  A 430 (-2.5A)
None
ANP  A 430 ( 4.5A)
 0.48A 3ohtB-3nieA:
26.9		 3ohtB-3nieA:
32.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pg1 MITOGEN-ACTIVATED
PROTEIN KINASE,
PUTATIVE (MAP
KINASE-LIKE PROTEIN)

(Leishmania
major) 		PF00069
(Pkinase) 		5 VAL A  37
ALA A  49
LYS A  51
LEU A  82
THR A 112
 None
 0.42A 3ohtB-3pg1A:
7.3		 3ohtB-3pg1A:
35.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
GLY A 804
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 ( 3.9A)
 0.75A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 727
VAL A 734
ALA A 751
LYS A 753
THR A 798
LEU A 852
 None
03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
03Q  A   1 (-4.4A)
 0.94A 3ohtB-3pp0A:
3.0		 3ohtB-3pp0A:
25.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		6 GLY A 558
VAL A 565
ALA A 576
LYS A 578
THR A 625
GLY A 631
 STU  A   1 (-3.2A)
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-3.2A)
 0.90A 3ohtB-3ppzA:
17.1		 3ohtB-3ppzA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  64
VAL A  71
ALA A  84
LEU A 119
ILE A 128
THR A 144
 ANP  A1634 ( 4.1A)
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
None
None
ANP  A1634 (-4.6A)
 0.46A 3ohtB-3q5iA:
3.9		 3ohtB-3q5iA:
27.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txo PROTEIN KINASE C ETA
TYPE

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		5 GLY A 362
VAL A 369
ALA A 382
LYS A 384
LEU A 407
 07U  A   1 ( 4.2A)
07U  A   1 (-4.8A)
07U  A   1 (-3.3A)
07U  A   1 (-3.0A)
None
 0.51A 3ohtB-3txoA:
5.1		 3ohtB-3txoA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
GLY A 703
 None
 0.84A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 626
VAL A 633
ALA A 649
ILE A 681
THR A 697
LEU A 751
 None
 0.95A 3ohtB-3zfxA:
16.9		 3ohtB-3zfxA:
27.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
GLY A 175
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-3.5A)
 0.97A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
ILE A 153
THR A 169
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
30K  A1365 (-3.8A)
30K  A1365 (-4.5A)
 0.98A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A  98
VAL A 105
ALA A 121
LYS A 123
ILE A 153
LEU A 223
 30K  A1365 ( 3.9A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
 1.01A 3ohtB-4aw5A:
17.5		 3ohtB-4aw5A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		6 GLY A 215
VAL A 222
ALA A 233
LYS A 235
THR A 283
LEU A 343
 None
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 (-4.7A)
 0.84A 3ohtB-4c02A:
4.5		 3ohtB-4c02A:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		6 GLY A 247
VAL A 254
ALA A 267
LYS A 269
LEU A 292
ILE A 302
 None
 0.71A 3ohtB-4c0tA:
5.6		 3ohtB-4c0tA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 617
VAL A 624
ALA A 653
LYS A 655
ILE A 685
THR A 701
 None
DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
 0.46A 3ohtB-4ckrA:
16.9		 3ohtB-4ckrA:
25.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  16
VAL A  23
ALA A  36
LYS A  38
LEU A  59
GLY A  92
 BX7  A 401 ( 3.8A)
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-3.3A)
 0.84A 3ohtB-4euuA:
2.5		 3ohtB-4euuA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 829
VAL A 836
ALA A 853
LYS A 855
LEU A 875
GLY A 908
 19S  A1201 (-3.7A)
19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 ( 3.8A)
 0.86A 3ohtB-4hviA:
16.8		 3ohtB-4hviA:
23.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzs ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14604
(SH3_9) 		5 GLY A 133
VAL A 140
ALA A 156
THR A 205
GLY A 211
 None
 0.53A 3ohtB-4hzsA:
4.9		 3ohtB-4hzsA:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 133
VAL A 140
ALA A 156
ILE A 190
THR A 205
GLY A 211
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
1G0  A 401 ( 4.5A)
 1.12A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4id7 ACTIVATED CDC42
KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 133
VAL A 140
ALA A 156
LYS A 158
ILE A 190
THR A 205
 1G0  A 401 ( 4.2A)
1G0  A 401 (-4.4A)
1G0  A 401 (-3.6A)
1G0  A 401 (-3.7A)
1G0  A 401 (-4.3A)
1G0  A 401 (-3.2A)
 0.68A 3ohtB-4id7A:
3.2		 3ohtB-4id7A:
23.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 479
VAL A 486
ALA A 506
LYS A 508
ILE A 539
 ACP  A 801 (-3.4A)
ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
None
 0.51A 3ohtB-4k33A:
5.4		 3ohtB-4k33A:
27.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY B  31
VAL B  38
ALA B  51
LYS B  53
LEU B  74
GLY B 103
 ADP  B 500 ( 3.8A)
ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
 0.73A 3ohtB-4o27B:
5.9		 3ohtB-4o27B:
24.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		6 GLY A 620
VAL A 627
ALA A 644
ILE A 676
THR A 692
LEU A 746
 None
 0.96A 3ohtB-4p2kA:
6.1		 3ohtB-4p2kA:
25.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		5 VAL A  35
ALA A  49
LYS A  51
LEU A  74
ILE A  83
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
None
ANP  A 402 (-4.8A)
 0.47A 3ohtB-4qnyA:
9.0		 3ohtB-4qnyA:
38.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		7 GLY B  31
VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
LEU B 167
 None
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
39G  B 401 (-3.6A)
 0.77A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		5 VAL B  38
ALA B  51
LEU B  75
ILE B  84
LEU B 167
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.3A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
 0.45A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14

(Mus musculus) 		PF00069
(Pkinase) 		6 VAL B  38
ALA B  51
LYS B  53
ILE B  84
THR B 106
ASN B 115
 None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 ( 3.8A)
39G  B 401 (-3.6A)
None
 0.85A 3ohtB-4tyhB:
34.3		 3ohtB-4tyhB:
86.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
 None
 0.49A 3ohtB-4xi2A:
6.1		 3ohtB-4xi2A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		5 GLY A 409
VAL A 416
ALA A 428
THR A 474
ASP A 539
 746  A 702 ( 3.5A)
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
 0.53A 3ohtB-4y93A:
5.3		 3ohtB-4y93A:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLY A 470
VAL A 477
ALA A 488
LYS A 490
LEU A 513
ILE A 522
THR A 539
 4CV  A 801 ( 3.9A)
None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
 0.63A 3ohtB-4yffA:
5.9		 3ohtB-4yffA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE

(Eimeria tenella) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		6 GLY A  35
VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
 ADP  A 506 (-3.5A)
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
 0.68A 3ohtB-4ysjA:
18.7		 3ohtB-4ysjA:
24.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		6 GLY A  32
VAL A  39
ALA A  52
LYS A  54
LEU A  73
GLY A 111
 GLY  A  32 ( 0.0A)
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
GLY  A 111 (-0.0A)
 0.69A 3ohtB-5d7aA:
18.3		 3ohtB-5d7aA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 251
VAL A 258
ALA A 275
LYS A 277
THR A 325
LEU A 386
 STU  A 601 (-2.9A)
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.9A)
 0.96A 3ohtB-5e8yA:
4.6		 3ohtB-5e8yA:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ezr CGMP-DEPENDENT
PROTEIN KINASE,
PUTATIVE

(Plasmodium
vivax) 		PF00027
(cNMP_binding)
PF00069
(Pkinase) 		6 GLY A 541
VAL A 548
ALA A 561
LYS A 563
ILE A 595
THR A 611
 4ZS  A 901 ( 4.5A)
4ZS  A 901 (-4.8A)
4ZS  A 901 ( 3.8A)
4ZS  A 901 (-3.9A)
4ZS  A 901 (-4.3A)
4ZS  A 901 (-3.2A)
 0.42A 3ohtB-5ezrA:
4.9		 3ohtB-5ezrA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 464
VAL A 471
ALA A 481
LYS A 483
THR A 529
 None
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.4A)
 0.50A 3ohtB-5fd2A:
17.1		 3ohtB-5fd2A:
26.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
None
None
PTR  A 809 (-2.4A)
 0.85A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fm2 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 731
VAL A 738
ALA A 756
LYS A 758
LEU A 779
ILE A 788
 PP1  A2012 ( 3.9A)
PP1  A2012 (-4.4A)
PP1  A2012 (-3.2A)
PP1  A2012 (-4.1A)
None
None
 0.59A 3ohtB-5fm2A:
16.5		 3ohtB-5fm2A:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
LYS A 627
THR A 674
GLY A 680
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
 0.76A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 GLY A 600
VAL A 607
ALA A 625
THR A 674
GLY A 680
ASN A 684
 None
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-3.2A)
748  A1001 ( 4.0A)
None
 0.81A 3ohtB-5grnA:
5.4		 3ohtB-5grnA:
26.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		6 VAL A  30
ALA A  43
LYS A  45
ILE A  66
THR A  82
GLY A  88
 032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 (-4.4A)
032  A 401 (-3.7A)
032  A 401 ( 4.0A)
 0.88A 3ohtB-5hesA:
4.7		 3ohtB-5hesA:
27.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxd DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 156
VAL A 163
ALA A 176
LYS A 178
ILE A 212
 7A7  A 501 (-3.2A)
7A7  A 501 (-4.4A)
7A7  A 501 (-3.5A)
7A7  A 501 (-3.5A)
7A7  A 501 (-4.8A)
 0.46A 3ohtB-5lxdA:
8.8		 3ohtB-5lxdA:
27.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 5 GLY A  18
VAL A  25
ALA A  38
LYS A  40
LEU A  61
 7LV  A 401 ( 3.9A)
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
None
 0.52A 3ohtB-5tvtA:
6.4		 3ohtB-5tvtA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		5 GLY A 117
VAL A 124
ALA A 137
LYS A 139
THR A 187
 H8H  A 401 ( 3.7A)
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
 0.49A 3ohtB-5vcxA:
18.0		 3ohtB-5vcxA:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
GLY A 969
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 ( 4.6A)
 0.83A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 6 GLY A 892
VAL A 899
ALA A 917
LYS A 919
THR A 963
LEU A1017
 ANP  A1201 ( 3.8A)
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.7A)
 0.99A 3ohtB-5wnoA:
4.7		 3ohtB-5wnoA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y86 DUAL SPECIFICITY
TYROSINE-PHOSPHORYLA
TION-REGULATED
KINASE 3

(Homo sapiens) 		no annotation 5 GLY A 216
VAL A 223
ALA A 236
LYS A 238
ILE A 272
 None
HRM  A 601 ( 4.9A)
HRM  A 601 (-3.5A)
HRM  A 601 (-3.3A)
HRM  A 601 ( 4.8A)
 0.51A 3ohtB-5y86A:
7.4		 3ohtB-5y86A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK

(Homo sapiens) 		no annotation 6 GLY A 532
VAL A 539
ALA A 551
LYS A 553
LEU A 575
ILE A 586
 CQ7  A 801 ( 4.0A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
CQ7  A 801 ( 4.5A)
 0.80A 3ohtB-6b4wA:
5.4		 3ohtB-6b4wA:
28.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2

(Homo sapiens) 		no annotation 6 GLY A 172
VAL A 179
ALA A 192
LYS A 194
LEU A 240
GLY A 273
 F6J  A 501 ( 3.9A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
None
F6J  A 501 ( 3.7A)
 0.75A 3ohtB-6cmjA:
6.5		 3ohtB-6cmjA:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fek PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE RECEPTOR RET

(Homo sapiens) 		no annotation 6 GLY A 731
VAL A 738
ALA A 756
LEU A 779
ILE A 788
GLY A 810
 ADN  A1104 ( 3.9A)
ADN  A1104 (-4.4A)
ADN  A1104 (-3.4A)
None
ADN  A1104 ( 4.7A)
ADN  A1104 ( 3.8A)
 0.78A 3ohtB-6fekA:
16.6		 3ohtB-6fekA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyl DUAL SPECIFICITY
PROTEIN KINASE CLK2

(Homo sapiens) 		no annotation 6 GLY A 170
VAL A 177
ALA A 191
LYS A 193
LEU A 212
GLY A 247
 3NG  A 501 (-3.5A)
3NG  A 501 ( 4.4A)
3NG  A 501 (-3.3A)
3NG  A 501 (-3.0A)
None
None
 0.72A 3ohtB-6fylA:
5.0		 3ohtB-6fylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5c FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Plasmodium
falciparum) 		PF00274
(Glycolytic) 		3 GLU A 194
LEU A 277
LEU A  36
 None
 0.68A 3ohtB-1a5cA:
undetectable		 3ohtB-1a5cA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ciy CRYIA(A)

(Bacillus
thuringiensis) 		PF00555
(Endotoxin_M)
PF03944
(Endotoxin_C)
PF03945
(Endotoxin_N) 		3 GLU A 235
LEU A  83
LEU A 157
 None
 0.70A 3ohtB-1ciyA:
undetectable		 3ohtB-1ciyA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cja PROTEIN
(ACTIN-FRAGMIN
KINASE)

(Physarum
polycephalum) 		PF09192
(Act-Frag_cataly) 		3 GLU A 106
LEU A 160
LEU A 164
 None
None
AMP  A 425 ( 4.8A)
 0.62A 3ohtB-1cjaA:
4.0		 3ohtB-1cjaA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjb PROTEIN
(HYPOXANTHINE-GUANIN
E
PHOSPHORIBOSYLTRANSF
ERASE)

(Plasmodium
falciparum) 		PF00156
(Pribosyltran) 		3 GLU A 144
LEU A 153
LEU A 180
 IRP  A 300 (-2.8A)
None
None
 0.76A 3ohtB-1cjbA:
undetectable		 3ohtB-1cjbA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d0n HORSE PLASMA
GELSOLIN

(Equus caballus) 		PF00626
(Gelsolin) 		3 GLU A  28
LEU A  33
LEU A  71
 None
 0.69A 3ohtB-1d0nA:
undetectable		 3ohtB-1d0nA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1epx FRUCTOSE-1,6-BISPHOS
PHATE ALDOLASE

(Leishmania
mexicana) 		PF00274
(Glycolytic) 		3 GLU A 197
LEU A 280
LEU A  40
 None
 0.72A 3ohtB-1epxA:
undetectable		 3ohtB-1epxA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2j FRUCTOSE-BISPHOSPHAT
E ALDOLASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00274
(Glycolytic) 		3 GLU A 197
LEU A 280
LEU A  40
 None
 0.75A 3ohtB-1f2jA:
undetectable		 3ohtB-1f2jA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fba FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Drosophila
melanogaster) 		PF00274
(Glycolytic) 		3 GLU A 187
LEU A 270
LEU A  30
 None
 0.74A 3ohtB-1fbaA:
undetectable		 3ohtB-1fbaA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fdj FRUCTOSE
1,6-BISPHOSPHATE
ALDOLASE

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 GLU A1187
LEU A1270
LEU A1030
 2FP  A5001 (-4.3A)
2FP  A5001 ( 3.9A)
None
 0.77A 3ohtB-1fdjA:
undetectable		 3ohtB-1fdjA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fxj UDP-N-ACETYLGLUCOSAM
INE
PYROPHOSPHORYLASE

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 GLU A 236
LEU A  30
LEU A  23
 GLU  A 236 ( 0.6A)
LEU  A  30 ( 0.6A)
LEU  A  23 ( 0.6A)
 0.67A 3ohtB-1fxjA:
undetectable		 3ohtB-1fxjA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 GLU A  38
LEU A 229
LEU A 260
 None
 0.62A 3ohtB-1i2dA:
undetectable		 3ohtB-1i2dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 GLU A 130
LEU A 147
LEU A 229
 None
 0.76A 3ohtB-1i2dA:
undetectable		 3ohtB-1i2dA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcm INDOLE-3-GLYCEROL-PH
OSPHATE SYNTHASE

(Escherichia
coli) 		PF00218
(IGPS) 		3 GLU P 214
LEU P 161
LEU P 176
 None
 0.61A 3ohtB-1jcmP:
undetectable		 3ohtB-1jcmP:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jed SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 GLU A 128
LEU A 145
LEU A 227
 None
None
TRS  A1415 ( 4.6A)
 0.74A 3ohtB-1jedA:
undetectable		 3ohtB-1jedA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0g P-AMINOBENZOATE
SYNTHASE COMPONENT I

(Escherichia
coli) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		3 GLU A  19
LEU A 231
LEU A 412
 None
 0.67A 3ohtB-1k0gA:
undetectable		 3ohtB-1k0gA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		3 GLU A 314
LEU A   3
LEU A  62
 None
 0.58A 3ohtB-1l5aA:
undetectable		 3ohtB-1l5aA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nbw GLYCEROL DEHYDRATASE
REACTIVASE ALPHA
SUBUNIT
GLYCEROL DEHYDRATASE
REACTIVASE BETA
SUBUNIT

(Klebsiella
pneumoniae) 		PF02288
(Dehydratase_MU)
PF08841
(DDR) 		3 GLU B  30
LEU A 172
LEU A 181
 None
 0.63A 3ohtB-1nbwB:
undetectable		 3ohtB-1nbwB:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qs0 2-OXOISOVALERATE
DEHYDROGENASE
BETA-SUBUNIT

(Pseudomonas
putida) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		3 GLU B 174
LEU B  12
LEU B  20
 None
 0.72A 3ohtB-1qs0B:
undetectable		 3ohtB-1qs0B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6x ATP:SULFATE
ADENYLYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		3 GLU A 128
LEU A 145
LEU A 227
 None
 0.75A 3ohtB-1r6xA:
undetectable		 3ohtB-1r6xA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rpn GDP-MANNOSE
4,6-DEHYDRATASE

(Pseudomonas
aeruginosa) 		PF16363
(GDP_Man_Dehyd) 		3 GLU A 128
LEU A 286
LEU A 305
 GDP  A1601 (-3.7A)
None
None
 0.77A 3ohtB-1rpnA:
undetectable		 3ohtB-1rpnA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rt8 FIMBRIN

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		3 GLU A 117
LEU A 351
LEU A 359
 None
 0.76A 3ohtB-1rt8A:
undetectable		 3ohtB-1rt8A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sv6 2-KETO-4-PENTENOATE
HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 GLU A 138
LEU A 229
LEU A 201
 None
 0.61A 3ohtB-1sv6A:
undetectable		 3ohtB-1sv6A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 GLU A 434
LEU A 379
LEU A 412
 None
 0.70A 3ohtB-1taqA:
3.9		 3ohtB-1taqA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tdj BIOSYNTHETIC
THREONINE DEAMINASE

(Escherichia
coli) 		PF00291
(PALP)
PF00585
(Thr_dehydrat_C) 		3 GLU A 308
LEU A 310
LEU A 174
 None
 0.62A 3ohtB-1tdjA:
undetectable		 3ohtB-1tdjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5u ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		no annotation 3 GLU A 226
LEU A 190
LEU A 271
 None
 0.74A 3ohtB-1u5uA:
undetectable		 3ohtB-1u5uA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ut9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Ruminiclostridium
thermocellum) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		3 GLU A 406
LEU A 629
LEU A 634
 None
 0.65A 3ohtB-1ut9A:
undetectable		 3ohtB-1ut9A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhh SONIC HEDGEHOG

(Mus musculus) 		PF01085
(HH_signal) 		3 GLU A  54
LEU A 140
LEU A 107
 None
 0.64A 3ohtB-1vhhA:
undetectable		 3ohtB-1vhhA:
17.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		3 GLU A 128
LEU A 152
LEU A 269
 None
 0.77A 3ohtB-1vknA:
undetectable		 3ohtB-1vknA:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vli SPORE COAT
POLYSACCHARIDE
BIOSYNTHESIS PROTEIN
SPSE

(Bacillus
subtilis) 		PF03102
(NeuB)
PF08666
(SAF) 		3 GLU A 163
LEU A 136
LEU A 343
 None
 0.78A 3ohtB-1vliA:
undetectable		 3ohtB-1vliA:
22.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vzy 33 KDA CHAPERONIN

(Bacillus
subtilis) 		PF01430
(HSP33) 		3 GLU A 199
LEU A 204
LEU A 170
 None
 0.66A 3ohtB-1vzyA:
undetectable		 3ohtB-1vzyA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x03 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Homo sapiens) 		PF03114
(BAR) 		3 GLU A 162
LEU A 166
LEU A 187
 None
 0.54A 3ohtB-1x03A:
2.0		 3ohtB-1x03A:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfb ALDOLASE C

(Homo sapiens) 		PF00274
(Glycolytic) 		3 GLU A 188
LEU A 271
LEU A  31
 None
 0.77A 3ohtB-1xfbA:
undetectable		 3ohtB-1xfbA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zws DAP-KINASE RELATED
PROTEIN 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  64
LEU A  91
LEU A  95
 None
 0.67A 3ohtB-1zwsA:
6.4		 3ohtB-1zwsA:
28.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2a DEATH-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  64
LEU A  91
LEU A  95
 None
 0.53A 3ohtB-2a2aA:
3.2		 3ohtB-2a2aA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2n TRANSCRIPTION-REPAIR
COUPLING FACTOR

(Escherichia
coli) 		no annotation 3 GLU A 304
LEU A 300
LEU A  76
 None
 0.76A 3ohtB-2b2nA:
undetectable		 3ohtB-2b2nA:
24.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bd0 SEPIAPTERIN
REDUCTASE

(Chlorobaculum
tepidum) 		PF00106
(adh_short) 		3 GLU A  33
LEU A  59
LEU A  20
 None
 0.70A 3ohtB-2bd0A:
undetectable		 3ohtB-2bd0A:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdw HYPOTHETICAL PROTEIN
K11E8.1D

(Caenorhabditis
elegans) 		PF00069
(Pkinase) 		3 GLU A  60
LEU A  87
LEU A  91
 None
 0.44A 3ohtB-2bdwA:
5.5		 3ohtB-2bdwA:
28.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bnh RIBONUCLEASE
INHIBITOR

(Sus scrofa) 		PF13516
(LRR_6) 		3 GLU A 294
LEU A 298
LEU A 330
 None
 0.62A 3ohtB-2bnhA:
undetectable		 3ohtB-2bnhA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c08 SH3-CONTAINING
GRB2-LIKE PROTEIN 2

(Rattus
norvegicus) 		PF03114
(BAR) 		3 GLU A 162
LEU A 166
LEU A 187
 None
 0.46A 3ohtB-2c08A:
2.1		 3ohtB-2c08A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2csn CASEIN KINASE-1

(Schizosaccharomyces
pombe) 		PF00069
(Pkinase) 		3 GLU A  55
LEU A  83
LEU A  87
 None
 0.76A 3ohtB-2csnA:
4.0		 3ohtB-2csnA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2det TRNA-SPECIFIC
2-THIOURIDYLASE MNMA

(Escherichia
coli) 		PF03054
(tRNA_Me_trans) 		3 GLU A 352
LEU A 142
LEU A 173
 None
 0.73A 3ohtB-2detA:
undetectable		 3ohtB-2detA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e2a PROTEIN (ENZYME IIA)

(Lactococcus
lactis) 		PF02255
(PTS_IIA) 		3 GLU A  12
LEU A   8
LEU A  70
 None
 0.53A 3ohtB-2e2aA:
2.7		 3ohtB-2e2aA:
14.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		3 GLU A 139
LEU A 236
LEU A 208
 MG  A1001 ( 3.0A)
None
None
 0.72A 3ohtB-2eb5A:
undetectable		 3ohtB-2eb5A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		3 GLU A  48
LEU A  67
LEU A  91
 None
 0.73A 3ohtB-2eryA:
undetectable		 3ohtB-2eryA:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1s VIRAL CASP8 AND
FADD-LIKE APOPTOSIS
REGULATOR

(Molluscum
contagiosum
virus) 		PF01335
(DED) 		3 GLU A 105
LEU A  27
LEU A  72
 None
 0.69A 3ohtB-2f1sA:
undetectable		 3ohtB-2f1sA:
18.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f42 STIP1 HOMOLOGY AND
U-BOX CONTAINING
PROTEIN 1

(Danio rerio) 		PF04564
(U-box) 		3 GLU A 239
LEU A 261
LEU A 265
 None
 0.75A 3ohtB-2f42A:
3.5		 3ohtB-2f42A:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS

(Homo sapiens) 		PF00071
(Ras) 		3 GLU A  63
LEU A  82
LEU A  45
 None
 0.77A 3ohtB-2fn4A:
undetectable		 3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fn4 RAS-RELATED PROTEIN
R-RAS

(Homo sapiens) 		PF00071
(Ras) 		3 GLU A  63
LEU A  82
LEU A 106
 None
 0.65A 3ohtB-2fn4A:
undetectable		 3ohtB-2fn4A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr2 HYPOTHETICAL PROTEIN
RV2717C

(Mycobacterium
tuberculosis) 		PF08768
(DUF1794) 		3 GLU A  67
LEU A  83
LEU A 118
 None
 0.53A 3ohtB-2fr2A:
undetectable		 3ohtB-2fr2A:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 GLU A 651
LEU A 647
LEU A 422
 None
 0.72A 3ohtB-2fuqA:
2.7		 3ohtB-2fuqA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		3 GLU A 597
LEU A 643
LEU A 698
 None
 0.74A 3ohtB-2gq3A:
undetectable		 3ohtB-2gq3A:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hqy CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		PF09924
(DUF2156) 		3 GLU A 172
LEU A 194
LEU A  40
 None
 0.63A 3ohtB-2hqyA:
undetectable		 3ohtB-2hqyA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxv DIAMINOHYDROXYPHOSPH
ORIBOSYLAMINOPYRIMID
INE DEAMINASE/
5-AMINO-6-(5-PHOSPHO
RIBOSYLAMINO)URACIL
REDUCTASE

(Thermotoga
maritima) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		3 GLU A  39
LEU A  12
LEU A 128
 None
 0.61A 3ohtB-2hxvA:
undetectable		 3ohtB-2hxvA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibg PROTEIN HEDGEHOG

(Drosophila
melanogaster) 		PF01085
(HH_signal) 		3 GLU E 113
LEU E 199
LEU E 166
 None
 0.68A 3ohtB-2ibgE:
undetectable		 3ohtB-2ibgE:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ilr FANCONI ANEMIA GROUP
E PROTEIN

(Homo sapiens) 		PF11510
(FA_FANCE) 		3 GLU A 506
LEU A 510
LEU A 476
 None
 0.59A 3ohtB-2ilrA:
undetectable		 3ohtB-2ilrA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n9v DERMONECROTIC TOXIN

(Pasteurella
multocida) 		PF11647
(MLD) 		3 GLU A  42
LEU A  40
LEU A  50
 None
 0.74A 3ohtB-2n9vA:
undetectable		 3ohtB-2n9vA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noq 60S RIBOSOMAL
PROTEIN L11-B

(Saccharomyces
cerevisiae) 		PF00281
(Ribosomal_L5)
PF00673
(Ribosomal_L5_C) 		3 GLU H  87
LEU H  83
LEU H  18
 None
 0.72A 3ohtB-2noqH:
undetectable		 3ohtB-2noqH:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nt8 COBALAMIN
ADENOSYLTRANSFERASE

(Lactobacillus
reuteri) 		PF01923
(Cob_adeno_trans) 		3 GLU A 135
LEU A 152
LEU A  65
 None
 0.78A 3ohtB-2nt8A:
undetectable		 3ohtB-2nt8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nxx ECDYSONE RECEPTOR
(ECR, NRH1)

(Tribolium
castaneum) 		PF00104
(Hormone_recep) 		3 GLU E 473
LEU E 383
LEU E 391
 None
 0.77A 3ohtB-2nxxE:
undetectable		 3ohtB-2nxxE:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocp DEOXYGUANOSINE
KINASE

(Homo sapiens) 		PF01712
(dNK) 		3 GLU A 211
LEU A 203
LEU A 192
 DTP  A 301 (-3.5A)
None
None
 0.65A 3ohtB-2ocpA:
undetectable		 3ohtB-2ocpA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 GLU A 236
LEU A  30
LEU A  23
 None
 0.69A 3ohtB-2oi6A:
undetectable		 3ohtB-2oi6A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pyj DNA POLYMERASE

(Bacillus virus
phi29) 		PF03175
(DNA_pol_B_2) 		3 GLU A 221
LEU A 351
LEU A 333
 None
None
EDO  A2771 (-4.8A)
 0.65A 3ohtB-2pyjA:
undetectable		 3ohtB-2pyjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb0 TELSAM DOMAIN -
LYSOZYME CHIMERA

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme)
PF02198
(SAM_PNT) 		3 GLU B 157
LEU B  24
LEU B  62
 MN  B 257 (-2.9A)
None
None
 0.74A 3ohtB-2qb0B:
2.2		 3ohtB-2qb0B:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r1i GCN5-RELATED
N-ACETYLTRANSFERASE

(Arthrobacter
sp. FB24) 		PF00583
(Acetyltransf_1) 		3 GLU A 134
LEU A 132
LEU A 124
 None
GOL  A 177 (-4.3A)
None
 0.75A 3ohtB-2r1iA:
undetectable		 3ohtB-2r1iA:
16.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2reb REC A

(Escherichia
coli) 		PF00154
(RecA) 		3 GLU A 154
LEU A 166
LEU A 126
 None
 0.76A 3ohtB-2rebA:
undetectable		 3ohtB-2rebA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjb UNCHARACTERIZED
PROTEIN

(Shigella
flexneri) 		PF07063
(DUF1338) 		3 GLU A 272
LEU A 270
LEU A 225
 None
 0.73A 3ohtB-2rjbA:
undetectable		 3ohtB-2rjbA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4k DEATH-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  64
LEU A  91
LEU A  95
 ADP  A1303 ( 4.8A)
None
None
 0.49A 3ohtB-2w4kA:
5.0		 3ohtB-2w4kA:
27.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wnt RIBOSOMAL PROTEIN S6
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A 459
LEU A 487
LEU A 491
 None
 0.71A 3ohtB-2wntA:
5.6		 3ohtB-2wntA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		3 GLU A 277
LEU A  15
LEU A  23
 None
 0.60A 3ohtB-2wocA:
undetectable		 3ohtB-2wocA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 GLU A1029
LEU A1032
LEU A1022
 None
 0.77A 3ohtB-2y3aA:
2.5		 3ohtB-2y3aA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yab DEATH-ASSOCIATED
PROTEIN KINASE 2

(Mus musculus) 		PF00069
(Pkinase) 		3 GLU A  64
LEU A  91
LEU A  95
 None
None
AMP  A1302 ( 4.9A)
 0.52A 3ohtB-2yabA:
5.5		 3ohtB-2yabA:
27.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Thermus
thermophilus) 		PF00117
(GATase)
PF00958
(GMP_synt_C) 		3 GLU A 361
LEU A 365
LEU A 377
 None
 0.73A 3ohtB-2ywbA:
2.0		 3ohtB-2ywbA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc0 ALANINE GLYOXYLATE
TRANSAMINASE

(Thermococcus
litoralis) 		PF00155
(Aminotran_1_2) 		3 GLU A  79
LEU A 288
LEU A  62
 None
 0.71A 3ohtB-2zc0A:
undetectable		 3ohtB-2zc0A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asm RIBONUCLEASE HIII

(Geobacillus
stearothermophilus) 		PF01351
(RNase_HII)
PF11858
(DUF3378) 		3 GLU A  74
LEU A  52
LEU A  33
 None
 0.71A 3ohtB-3asmA:
undetectable		 3ohtB-3asmA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc1 RAS-RELATED PROTEIN
RAB-27A

(Mus musculus) 		PF00071
(Ras) 		3 GLU A 161
LEU A 101
LEU A 108
 None
 0.70A 3ohtB-3bc1A:
undetectable		 3ohtB-3bc1A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  61
LEU A  88
LEU A  92
 None
None
5CP  A 600 (-4.6A)
 0.65A 3ohtB-3bhhA:
5.8		 3ohtB-3bhhA:
28.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv4 FRUCTOSE-BISPHOSPHAT
E ALDOLASE A

(Oryctolagus
cuniculus) 		PF00274
(Glycolytic) 		3 GLU A 187
LEU A 270
LEU A  30
 None
13P  A3371 (-3.8A)
None
 0.77A 3ohtB-3bv4A:
undetectable		 3ohtB-3bv4A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bvh FIBRINOGEN BETA
CHAIN

(Homo sapiens) 		PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 GLU B 313
LEU B 311
LEU B 294
 None
 0.75A 3ohtB-3bvhB:
undetectable		 3ohtB-3bvhB:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clm TRANSALDOLASE

(Neisseria
gonorrhoeae) 		PF00923
(TAL_FSA) 		3 GLU A 122
LEU A 112
LEU A 163
 None
 0.48A 3ohtB-3clmA:
undetectable		 3ohtB-3clmA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cpf EUKARYOTIC
TRANSLATION
INITIATION FACTOR
5A-1

(Homo sapiens) 		PF01287
(eIF-5a) 		3 GLU A 144
LEU A 112
LEU A 134
 UNX  A   5 (-3.9A)
UNX  A   1 (-4.1A)
None
 0.76A 3ohtB-3cpfA:
undetectable		 3ohtB-3cpfA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dmk DOWN SYNDROME CELL
ADHESION MOLECULE
(DSCAM) ISOFORM
1.30.30, N-TERMINAL
EIGHT IG DOMAINS

(Drosophila
melanogaster) 		PF07679
(I-set)
PF13927
(Ig_3) 		3 GLU A 165
LEU A 234
LEU A 217
 None
 0.78A 3ohtB-3dmkA:
undetectable		 3ohtB-3dmkA:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzd TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		3 GLU A 135
LEU A 140
LEU A 299
 None
 0.73A 3ohtB-3dzdA:
undetectable		 3ohtB-3dzdA:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e10 PUTATIVE NADH
OXIDASE

(Clostridium
acetobutylicum) 		PF00881
(Nitroreductase) 		3 GLU A  97
LEU A 101
LEU A  27
 None
 0.77A 3ohtB-3e10A:
undetectable		 3ohtB-3e10A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2s PROLINE
DEHYDROGENASE

(Escherichia
coli) 		PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		3 GLU A 385
LEU A 420
LEU A 412
 None
 0.73A 3ohtB-3e2sA:
undetectable		 3ohtB-3e2sA:
19.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3e7o MITOGEN-ACTIVATED
PROTEIN KINASE 9

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  73
LEU A 106
LEU A 110
 None
None
35F  A   1 (-4.5A)
 0.42A 3ohtB-3e7oA:
8.1		 3ohtB-3e7oA:
46.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek1 ALDEHYDE
DEHYDROGENASE

(Brucella
abortus) 		PF00171
(Aldedh) 		3 GLU A 198
LEU A  15
LEU A 188
 None
 0.66A 3ohtB-3ek1A:
undetectable		 3ohtB-3ek1A:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ek3 NITROREDUCTASE

(Bacteroides
fragilis) 		PF00881
(Nitroreductase) 		3 GLU A 117
LEU A 121
LEU A  33
 None
 0.62A 3ohtB-3ek3A:
undetectable		 3ohtB-3ek3A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		3 GLU A 198
LEU A 160
LEU A 168
 None
 0.69A 3ohtB-3eslA:
undetectable		 3ohtB-3eslA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euc HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE 2

(Cupriavidus
pinatubonensis) 		PF00155
(Aminotran_1_2) 		3 GLU A 269
LEU A 265
LEU A 229
 None
 0.78A 3ohtB-3eucA:
undetectable		 3ohtB-3eucA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2i ALR0221 PROTEIN

(Nostoc sp. PCC
7120) 		PF00300
(His_Phos_1) 		3 GLU A  75
LEU A  49
LEU A   5
 None
 0.64A 3ohtB-3f2iA:
undetectable		 3ohtB-3f2iA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fok UNCHARACTERIZED
PROTEIN CGL0159

(Corynebacterium
glutamicum) 		no annotation 3 GLU A 182
LEU A 243
LEU A  44
 None
 0.71A 3ohtB-3fokA:
undetectable		 3ohtB-3fokA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fww BIFUNCTIONAL PROTEIN
GLMU

(Yersinia pestis) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		3 GLU A 236
LEU A  30
LEU A  23
 None
 0.69A 3ohtB-3fwwA:
undetectable		 3ohtB-3fwwA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyd PROBABLE
DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLU A  36
LEU A  48
LEU A  74
 None
 0.61A 3ohtB-3fydA:
undetectable		 3ohtB-3fydA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		3 GLU A 210
LEU A   9
LEU A  78
 None
 0.75A 3ohtB-3g5aA:
undetectable		 3ohtB-3g5aA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gd5 ORNITHINE
CARBAMOYLTRANSFERASE

(Gloeobacter
violaceus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		3 GLU A 150
LEU A 146
LEU A 160
 None
 0.75A 3ohtB-3gd5A:
undetectable		 3ohtB-3gd5A:
21.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		3 GLU A  71
LEU A 104
LEU A 108
 NIL  A   1 (-3.7A)
NIL  A   1 ( 4.3A)
NIL  A   1 ( 4.4A)
 0.33A 3ohtB-3gp0A:
32.9		 3ohtB-3gp0A:
68.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gry DIMETHYLADENOSINE
TRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00398
(RrnaAD) 		3 GLU A  36
LEU A  48
LEU A  74
 SAM  A 300 (-4.4A)
None
None
 0.62A 3ohtB-3gryA:
undetectable		 3ohtB-3gryA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h2z MANNITOL-1-PHOSPHATE
5-DEHYDROGENASE

(Shigella
flexneri) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		3 GLU A 282
LEU A 240
LEU A 226
 None
 0.73A 3ohtB-3h2zA:
undetectable		 3ohtB-3h2zA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h92 UNCHARACTERIZED
ATP-BINDING PROTEIN
MJECL15

(Methanocaldococcus
jannaschii) 		no annotation 3 GLU A  65
LEU A  20
LEU A  83
 None
 0.74A 3ohtB-3h92A:
undetectable		 3ohtB-3h92A:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hba PUTATIVE
PHOSPHOSUGAR
ISOMERASE

(Shewanella
denitrificans) 		PF01380
(SIS) 		3 GLU A 227
LEU A 223
LEU A 256
 None
 0.77A 3ohtB-3hbaA:
undetectable		 3ohtB-3hbaA:
21.14