SIMILAR PATTERNS OF AMINO ACIDS FOR 3OGW_A_IMNA597_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		7 GLN A  91
HIS A  95
PHE A  99
GLU A 102
ARG C 239
GLU C 242
PHE C 366
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.9A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
None
 0.73A 3ogwA-1d7wA:
3.7		 3ogwA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1d7w MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		7 GLN A  91
HIS A  95
PHE A  99
GLU A 102
ARG C 239
GLU C 242
PHE C 407
 HEM  A 605 ( 3.4A)
CYN  A1844 (-4.1A)
HEM  A 605 (-4.9A)
None
HEM  A 605 (-4.3A)
HEM  A 605 (-2.1A)
HEM  A 605 (-4.5A)
 1.44A 3ogwA-1d7wA:
3.7		 3ogwA-1d7wA:
38.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gjm LACTOPEROXIDASE

(Bubalus bubalis) 		PF03098
(An_peroxidase) 		8 GLN A  91
HIS A  95
PHE A  99
GLU A 102
ARG A 239
GLU A 242
PHE A 366
GLN A 408
 HEM  A 605 (-3.4A)
SCN  A1502 ( 4.8A)
HEM  A 605 (-4.8A)
None
HEM  A 605 (-4.7A)
HEM  A 605 ( 2.2A)
None
HEM  A 605 ( 4.6A)
 0.50A 3ogwA-2gjmA:
65.8		 3ogwA-2gjmA:
99.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kal HOMOGLUTATHIONE
SYNTHETASE

(Glycine max) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		5 GLN A 338
PHE A 363
GLU A 347
GLU A 339
PHE A 113
 None
 1.20A 3ogwA-3kalA:
0.0		 3ogwA-3kalA:
23.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lc9 GLUCOKINASE
REGULATORY PROTEIN

(Rattus
norvegicus) 		no annotation 5 GLN A   8
HIS A   9
PHE A  61
GLU A  64
GLN A  72
 None
 1.41A 3ogwA-4lc9A:
1.4		 3ogwA-4lc9A:
23.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		5 GLN A 257
HIS A 261
PHE A 265
ARG A 405
PHE A 573
 HEM  A 812 (-3.3A)
None
None
HEM  A 812 (-3.7A)
HEM  A 812 ( 3.9A)
 0.94A 3ogwA-5mfaA:
54.2		 3ogwA-5mfaA:
49.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5mfa MYELOPEROXIDASE

(Homo sapiens) 		PF03098
(An_peroxidase) 		6 GLN A 257
HIS A 261
PHE A 265
GLU A 268
ARG A 405
PHE A 532
 HEM  A 812 (-3.3A)
None
None
HEM  A 812 ( 4.9A)
HEM  A 812 (-3.7A)
TRS  A 824 ( 4.8A)
 0.76A 3ogwA-5mfaA:
54.2		 3ogwA-5mfaA:
49.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 GLN A 257
HIS A 261
PHE A 265
ARG A 405
PHE A 532
 None
 0.54A 3ogwA-6azpA:
60.5		 3ogwA-6azpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 GLN A 257
HIS A 261
PHE A 265
ARG A 405
PHE A 573
 None
 1.05A 3ogwA-6azpA:
60.5		 3ogwA-6azpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 GLN A 257
HIS A 261
PHE A 265
GLU A 268
PHE A 532
 None
 0.79A 3ogwA-6azpA:
60.5		 3ogwA-6azpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6azp MYELOPEROXIDASE

(Homo sapiens) 		no annotation 5 GLN A 257
HIS A 261
PHE A 265
GLU A 268
PHE A 573
 None
 1.34A 3ogwA-6azpA:
60.5		 3ogwA-6azpA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6erc PEROXINECTIN A

(Dictyostelium
discoideum) 		no annotation 5 GLN A  97
HIS A 101
ARG A 233
GLU A 236
PHE A 352
 HEM  A 604 (-3.4A)
None
HEM  A 604 (-3.1A)
HEM  A 604 (-2.2A)
None
 0.72A 3ogwA-6ercA:
39.5		 3ogwA-6ercA:
9.17