SIMILAR PATTERNS OF AMINO ACIDS FOR 3OGQ_A_AB1A200_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bvy PROTEIN (CYTOCHROME
P450 BM-3)

(Bacillus
megaterium) 		PF00258
(Flavodoxin_1) 		5 LEU F 483
ALA F 501
ASP F 502
ILE F 503
GLY F 495
 None
 0.96A 3ogqA-1bvyF:
undetectable		 3ogqA-1bvyF:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		5 ALA A 534
ILE A 536
GLY A 528
ILE A 527
LEU A 274
 None
 0.96A 3ogqA-1ehkA:
undetectable		 3ogqA-1ehkA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekq HYDROXYETHYLTHIAZOLE
KINASE

(Bacillus
subtilis) 		PF02110
(HK) 		5 LEU A 215
ALA A 119
VAL A 204
GLY A 122
ILE A 167
 None
 0.90A 3ogqA-1ekqA:
undetectable		 3ogqA-1ekqA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  48
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 (-4.1A)
 0.78A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  48
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.4A)
A79  A 800 (-3.6A)
 1.02A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 (-2.8A)
A79  A 800 ( 4.4A)
A79  A 800 ( 3.7A)
 0.57A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 (-2.7A)
A79  A 800 ( 4.3A)
A79  A 800 (-3.4A)
 0.60A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
VAL A  32
GLY A  49
ILE A  50
 A79  A 800 ( 3.8A)
A79  A 800 (-2.7A)
A79  A 800 (-3.1A)
A79  A 800 ( 4.4A)
A79  A 800 ( 3.7A)
A79  A 800 (-3.8A)
 0.60A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvc HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
VAL A  32
GLY A  49
ILE A  50
 A79  A 800 ( 4.0A)
A79  A 800 (-2.8A)
A79  A 800 (-3.2A)
A79  A 800 ( 4.3A)
A79  A 800 (-3.4A)
A79  A 800 ( 4.0A)
 0.62A 3ogqA-1hvcA:
9.9		 3ogqA-1hvcA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ize ASPARTIC PROTEINASE

(Aspergillus
oryzae) 		PF00026
(Asp) 		5 LEU A 219
ASP A 223
ILE A 226
GLY A 211
ILE A 212
 None
 0.99A 3ogqA-1izeA:
8.3		 3ogqA-1izeA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV

(Thermotoga
maritima) 		PF00227
(Proteasome) 		6 LEU A 130
ASP A  17
ILE A 166
VAL A 148
GLY A  45
LEU A   4
 None
 1.40A 3ogqA-1m4yA:
undetectable		 3ogqA-1m4yA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mox EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		5 LEU A 368
VAL A 374
GLY A 315
ILE A 316
LEU A 371
 None
 0.88A 3ogqA-1moxA:
undetectable		 3ogqA-1moxA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o12 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 LEU A 165
VAL A 192
GLY A 175
ILE A 119
LEU A 172
 None
 0.94A 3ogqA-1o12A:
undetectable		 3ogqA-1o12A:
16.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 ELECTRON TRANSFER
FLAVOPROTEIN
BETA-SUBUNIT

(Methylophilus
methylotrophus) 		PF01012
(ETF) 		5 ALA C   6
VAL C 116
GLY C 101
ILE C 103
LEU C   4
 AMP  C1236 (-3.6A)
None
None
None
None
 1.00A 3ogqA-1o94C:
undetectable		 3ogqA-1o94C:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p1m HYPOTHETICAL PROTEIN
TM0936

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 LEU A 232
ILE A 268
VAL A 264
MET A 316
ILE A 225
 None
 0.96A 3ogqA-1p1mA:
undetectable		 3ogqA-1p1mA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  48
 None
 0.79A 3ogqA-1sivA:
15.6		 3ogqA-1sivA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  49
 None
 0.33A 3ogqA-1sivA:
15.6		 3ogqA-1sivA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1siv SIV PROTEASE

(Simian
immunodeficiency
virus) 		PF00077
(RVP) 		5 LEU A  23
ASP A  25
ALA A  28
GLY A  49
ILE A  50
 None
 0.49A 3ogqA-1sivA:
15.6		 3ogqA-1sivA:
28.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1umf CHORISMATE SYNTHASE

(Helicobacter
pylori) 		PF01264
(Chorismate_synt) 		6 LEU A   4
ALA A 135
ILE A  79
GLY A  22
ILE A  21
LEU A  10
 None
 1.47A 3ogqA-1umfA:
undetectable		 3ogqA-1umfA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzg MAJOR ENVELOPE
PROTEIN E

(Dengue virus) 		PF00869
(Flavi_glycoprot)
PF02832
(Flavi_glycop_C) 		6 LEU A 285
ALA A 171
ILE A 172
GLY A 157
ILE A 140
LEU A 179
 None
 1.26A 3ogqA-1uzgA:
undetectable		 3ogqA-1uzgA:
15.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5i IA-1=SERINE
PROTEINASE INHIBITOR

(Pleurotus
ostreatus) 		no annotation 5 LEU B  53
VAL B  25
GLY B  43
ILE B   8
LEU B  48
 None
 1.01A 3ogqA-1v5iB:
undetectable		 3ogqA-1v5iB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yd7 2-KETO
ACID:FERREDOXIN
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF01855
(POR_N) 		5 LEU A 147
ASP A 178
VAL A 111
GLY A  17
LEU A 175
 None
 1.00A 3ogqA-1yd7A:
undetectable		 3ogqA-1yd7A:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3o PYRUVATE-FERREDOXIN
OXIDOREDUCTASE

(Desulfovibrio
africanus) 		PF01558
(POR)
PF01855
(POR_N)
PF02775
(TPP_enzyme_C)
PF10371
(EKR)
PF13484
(Fer4_16)
PF17147
(PFOR_II) 		5 LEU A 914
ALA A 897
VAL A 906
GLY A 943
LEU A 910
 None
 0.89A 3ogqA-2c3oA:
undetectable		 3ogqA-2c3oA:
6.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cay VACUOLAR PROTEIN
SORTING PROTEIN 36

(Saccharomyces
cerevisiae) 		PF11605
(Vps36_ESCRT-II) 		6 LEU A  90
ASP A  73
VAL A 256
GLY A  68
ILE A  55
LEU A  92
 None
 1.30A 3ogqA-2cayA:
undetectable		 3ogqA-2cayA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg8 DIHYDRONEOPTERIN
ALDOLASE
6-HYDROXYMETHYL-7,8-
DIHYDROPTERIN
SYNTHASE

(Streptococcus
pneumoniae) 		PF01288
(HPPK)
PF02152
(FolB) 		5 LEU A  79
ALA A  32
ILE A  33
ILE A  29
LEU A  95
 None
 0.94A 3ogqA-2cg8A:
undetectable		 3ogqA-2cg8A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cje DUTPASE

(Leishmania
major) 		PF08761
(dUTPase_2) 		5 LEU A  52
ALA A 164
ILE A 162
GLY A 169
LEU A  77
 None
 1.02A 3ogqA-2cjeA:
undetectable		 3ogqA-2cjeA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fa0 HMG-COA SYNTHASE

(Brassica juncea) 		PF01154
(HMG_CoA_synt_N)
PF08540
(HMG_CoA_synt_C) 		5 LEU A  65
ALA A 166
ILE A  12
ILE A 169
LEU A  64
 None
 0.87A 3ogqA-2fa0A:
undetectable		 3ogqA-2fa0A:
15.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  54
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
None
LP1  A 201 (-3.6A)
 0.91A 3ogqA-2fmbA:
15.2		 3ogqA-2fmbA:
33.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fmb EQUINE INFECTIOUS
ANEMIA VIRUS
PROTEASE

(Equine
infectious
anemia virus) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  55
 None
LP1  A 201 (-2.3A)
LP1  A 201 (-3.5A)
LP1  A 201 (-3.6A)
None
LP1  A 201 (-3.4A)
 0.47A 3ogqA-2fmbA:
15.2		 3ogqA-2fmbA:
33.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpo METHYLASE YHHF

(Escherichia
coli) 		PF03602
(Cons_hypoth95) 		5 ASP A  58
ALA A  61
VAL A 105
ILE A  12
LEU A  80
 None
 0.83A 3ogqA-2fpoA:
undetectable		 3ogqA-2fpoA:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		6 LEU A 175
ALA A 311
ASP A 310
ILE A 167
GLY A  11
ILE A   9
 None
None
FAD  A 403 (-2.7A)
None
FAD  A 403 (-3.2A)
None
 1.12A 3ogqA-2rgjA:
undetectable		 3ogqA-2rgjA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkf PROTEASE RETROPEPSIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  49
ILE A  50
 None
AB1  A 501 (-2.4A)
AB1  A 501 (-3.5A)
AB1  A 501 ( 3.3A)
AB1  A 501 (-3.5A)
AB1  A 501 (-3.8A)
 0.66A 3ogqA-2rkfA:
15.0		 3ogqA-2rkfA:
27.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsp RSV PROTEASE

(Rous sarcoma
virus) 		PF00077
(RVP) 		5 LEU A  35
ASP A  37
ALA A  40
ASP A  41
ILE A  42
 None
 0.40A 3ogqA-2rspA:
12.1		 3ogqA-2rspA:
26.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 ASP A 221
ILE A 389
VAL A 223
MET A 356
GLY A 206
 FAD  A 601 (-3.5A)
None
None
None
None
 1.00A 3ogqA-2wu5A:
undetectable		 3ogqA-2wu5A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5x AMINE OXIDASE
[FLAVIN-CONTAINING]
A

(Homo sapiens) 		PF01593
(Amino_oxidase) 		6 LEU A 233
ALA A  29
VAL A 238
GLY A  22
ILE A  23
LEU A 234
 None
None
None
FAD  A 600 (-3.2A)
FAD  A 600 (-4.9A)
None
 1.33A 3ogqA-2z5xA:
undetectable		 3ogqA-2z5xA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A A SUBUNIT

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.98A 3ogqA-3c5wA:
undetectable		 3ogqA-3c5wA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		5 ALA A 102
ASP A 101
ILE A  72
GLY A  95
ILE A  94
 PEG  A 404 ( 4.7A)
None
None
None
None
 0.92A 3ogqA-3ce9A:
undetectable		 3ogqA-3ce9A:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		5 LEU A 151
ALA A  12
VAL A  38
GLY A  25
LEU A  10
 None
 0.84A 3ogqA-3dffA:
undetectable		 3ogqA-3dffA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3en0 CYANOPHYCINASE

(Synechocystis
sp. PCC 6803) 		PF03575
(Peptidase_S51) 		5 LEU A 104
ALA A 136
ILE A 143
GLY A  13
ILE A  12
 None
 0.94A 3ogqA-3en0A:
undetectable		 3ogqA-3en0A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxt NUCLEOSIDE
DIPHOSPHATE-LINKED
MOIETY X MOTIF 6

(Homo sapiens) 		no annotation 5 LEU A 125
ILE A  56
VAL A  58
GLY A  77
LEU A  95
 None
 1.01A 3ogqA-3fxtA:
undetectable		 3ogqA-3fxtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h09 IMMUNOGLOBULIN A1
PROTEASE

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		5 LEU A 452
ILE A 499
VAL A 497
ILE A 461
LEU A 472
 None
 1.00A 3ogqA-3h09A:
undetectable		 3ogqA-3h09A:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iha SALT-TOLERANT
GLUTAMINASE

(Micrococcus
luteus) 		PF04960
(Glutaminase) 		6 LEU A 409
ALA A 346
ASP A 349
VAL A 320
GLY A 314
LEU A 329
 None
 1.27A 3ogqA-3ihaA:
undetectable		 3ogqA-3ihaA:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  48
 None
 0.93A 3ogqA-3mwsA:
15.9		 3ogqA-3mwsA:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mws HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
ILE A  50
 None
 0.59A 3ogqA-3mwsA:
15.9		 3ogqA-3mwsA:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njp EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain)
PF14843
(GF_recep_IV) 		5 LEU A 368
VAL A 374
GLY A 315
ILE A 316
LEU A 371
 None
 0.90A 3ogqA-3njpA:
undetectable		 3ogqA-3njpA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		5 LEU A  30
ASP A 157
VAL A 153
GLY A 126
LEU A   7
 None
 1.00A 3ogqA-3oz2A:
undetectable		 3ogqA-3oz2A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozb METHYLTHIOADENOSINE
PHOSPHORYLASE

(Pseudomonas
aeruginosa) 		PF01048
(PNP_UDP_1) 		5 LEU A 257
ILE A 246
VAL A 249
ILE A  21
LEU A 253
 None
 0.92A 3ogqA-3ozbA:
undetectable		 3ogqA-3ozbA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		6 ALA A 114
ASP A 115
ILE A 116
GLY A 108
ILE A 107
LEU A  84
 None
 1.20A 3ogqA-3prlA:
undetectable		 3ogqA-3prlA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qlj SHORT CHAIN
DEHYDROGENASE

(Mycobacterium
avium) 		PF00106
(adh_short) 		5 LEU A 238
ILE A  10
VAL A   9
GLY A  19
ILE A  18
 None
 1.02A 3ogqA-3qljA:
undetectable		 3ogqA-3qljA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slz GAG-PRO-POL
POLYPROTEIN

(Murine leukemia
virus) 		PF00077
(RVP) 		6 LEU A  30
ASP A  32
ALA A  35
VAL A  39
GLY A  56
LEU A  92
 None
3TL  A 126 (-2.4A)
3TL  A 126 ( 4.0A)
None
3TL  A 126 (-3.4A)
3TL  A 126 (-4.6A)
 0.43A 3ogqA-3slzA:
11.8		 3ogqA-3slzA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t3c HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
ILE A  50
 SO4  A 101 (-4.2A)
017  A 201 (-2.6A)
017  A 201 (-3.5A)
017  A 201 (-3.5A)
None
017  A 201 (-4.0A)
017  A 201 (-3.3A)
 0.64A 3ogqA-3t3cA:
15.1		 3ogqA-3t3cA:
29.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttp HIV-1 PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  49
ILE A  50
 None
017  A 201 (-2.6A)
017  A 201 (-3.4A)
017  A 201 (-3.3A)
017  A 201 (-3.0A)
017  A 201 (-3.3A)
 0.61A 3ogqA-3ttpA:
15.3		 3ogqA-3ttpA:
26.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7s POL POLYPROTEIN

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  49
ILE A  50
 None
017  A 202 ( 2.5A)
017  A 201 (-3.4A)
017  A 201 (-3.2A)
017  A 202 (-2.9A)
017  A 201 ( 3.5A)
 0.50A 3ogqA-3u7sA:
15.4		 3ogqA-3u7sA:
28.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d1t METALLO-B-LACTAMASE

(Pseudomonas
aeruginosa) 		PF00753
(Lactamase_B) 		5 LEU A  96
ALA A  86
VAL A  42
ILE A  83
LEU A  95
 None
 1.01A 3ogqA-4d1tA:
undetectable		 3ogqA-4d1tA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 LEU A 203
ALA A 209
ASP A 210
ILE A 179
LEU A 204
 None
 0.99A 3ogqA-4idaA:
undetectable		 3ogqA-4idaA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6m POLYPROTEIN

(Japanese
encephalitis
virus) 		PF00972
(Flavi_NS5)
PF01728
(FtsJ) 		5 ALA A 567
ILE A 571
VAL A 555
GLY A 492
LEU A 559
 None
 1.01A 3ogqA-4k6mA:
undetectable		 3ogqA-4k6mA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		5 LEU A  69
ASP A  57
ALA A  60
ASP A  80
ILE A  86
 None
None
None
SAH  A 502 (-2.5A)
None
 0.95A 3ogqA-4krgA:
undetectable		 3ogqA-4krgA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv7 PROBABLE
LEUCINE/ISOLEUCINE/V
ALINE-BINDING
PROTEIN

(Rhodopirellula
baltica) 		PF13458
(Peripla_BP_6) 		5 LEU A 412
ALA A 181
ASP A 180
ILE A 254
LEU A 411
 None
 1.00A 3ogqA-4kv7A:
undetectable		 3ogqA-4kv7A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l5i TRANSCRIPTIONAL
REGULATOR LSRR

(Escherichia
coli) 		PF04198
(Sugar-bind) 		5 LEU A 120
ILE A 171
VAL A 169
GLY A 161
LEU A 146
 None
 0.76A 3ogqA-4l5iA:
undetectable		 3ogqA-4l5iA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l9r INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 LEU A 184
ALA A 139
GLY A 246
ILE A 247
LEU A 140
 None
 0.95A 3ogqA-4l9rA:
undetectable		 3ogqA-4l9rA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lac PP2A SCAFFOLD
SUBUNIT A,
TRUNCATED, AN
INTERNAL DELETION OF
PP2A A

(Homo sapiens) 		PF02985
(HEAT)
PF13646
(HEAT_2) 		5 LEU A 567
ALA A 582
GLY A 548
ILE A 547
LEU A 564
 None
 0.96A 3ogqA-4lacA:
undetectable		 3ogqA-4lacA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 LEU A  72
ALA A  95
VAL A  64
GLY A  88
LEU A  68
 None
 1.01A 3ogqA-4mydA:
undetectable		 3ogqA-4mydA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4myd 2-SUCCINYL-6-HYDROXY
-2,4-CYCLOHEXADIENE-
1-CARBOXYLATE
SYNTHASE

(Escherichia
coli) 		PF12697
(Abhydrolase_6) 		5 LEU A  72
ALA A  95
VAL A  64
GLY A  89
LEU A  68
 None
 0.85A 3ogqA-4mydA:
undetectable		 3ogqA-4mydA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndm T-CELL GAMMA
PROTEIN,T-CELL
RECEPTOR BETA-2
CHAIN C REGION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 LEU A  60
ASP A  58
ILE A  34
ILE A  82
LEU A  49
 None
 0.92A 3ogqA-4ndmA:
undetectable		 3ogqA-4ndmA:
16.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  48
 None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
None
RIT  A 500 (-4.8A)
 0.94A 3ogqA-4njvA:
15.0		 3ogqA-4njvA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
 None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.6A)
RIT  A 500 (-3.2A)
None
RIT  A 500 (-3.4A)
 0.52A 3ogqA-4njvA:
15.0		 3ogqA-4njvA:
32.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4njv PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
VAL A  32
GLY A  49
ILE A  50
 None
RIT  A 500 (-2.4A)
RIT  A 500 (-3.6A)
None
RIT  A 500 (-3.4A)
RIT  A 500 (-4.3A)
 0.51A 3ogqA-4njvA:
15.0		 3ogqA-4njvA:
32.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu2 ANTIFREEZE PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 LEU A 178
VAL A 229
GLY A 239
ILE A 221
LEU A 202
 None
 0.82A 3ogqA-4nu2A:
undetectable		 3ogqA-4nu2A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nu3 ICE-BINDING PROTEIN

(Flavobacterium
frigoris) 		PF11999
(DUF3494) 		5 LEU A 158
VAL A 209
GLY A 219
ILE A 201
LEU A 182
 None
 0.84A 3ogqA-4nu3A:
undetectable		 3ogqA-4nu3A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		6 LEU A 298
ILE A 255
VAL A 256
GLY A 284
ILE A 273
LEU A 289
 None
 1.49A 3ogqA-4o6rA:
undetectable		 3ogqA-4o6rA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3n MGS-M5

(unidentified) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 305
ASP A 124
ILE A 142
VAL A 257
ILE A 172
 None
 0.94A 3ogqA-4q3nA:
undetectable		 3ogqA-4q3nA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydf HTLV-1 PROTEASE

(Primate
T-lymphotropic
virus 1) 		PF00077
(RVP) 		6 LEU A  30
ASP A  32
ALA A  35
ASP A  36
VAL A  39
GLY A  58
 None
4B1  A 201 (-2.9A)
4B1  A 201 (-3.6A)
4B1  A 201 (-4.4A)
None
4B1  A 201 (-3.4A)
 0.62A 3ogqA-4ydfA:
12.5		 3ogqA-4ydfA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yji ARYL ACYLAMIDASE

(bacterium
CSBL00001) 		PF01425
(Amidase) 		6 LEU A 256
ALA A 466
ASP A 463
VAL A 470
GLY A 440
ILE A 204
 None
 1.21A 3ogqA-4yjiA:
undetectable		 3ogqA-4yjiA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z79 LEIOMODIN-1
ACTIN-BINDING SITE 2
(ABS2)

(Homo sapiens) 		no annotation 6 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
None
GOL  A 502 ( 4.3A)
None
None
None
 1.38A 3ogqA-4z79A:
undetectable		 3ogqA-4z79A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8g TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA
(TP1 ABS2)

(Homo sapiens) 		no annotation 6 LEU A 417
ALA A 410
ILE A 381
GLY A 403
ILE A 404
LEU A 383
 None
 1.38A 3ogqA-4z8gA:
undetectable		 3ogqA-4z8gA:
23.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z94 GELSOLIN,
TROPOMODULIN-1,
LEIOMODIN-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		6 LEU G1417
ALA G1410
ILE G1381
GLY G1403
ILE G1404
LEU G1383
 None
 1.33A 3ogqA-4z94G:
undetectable		 3ogqA-4z94G:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a51 AT3G17980

(Arabidopsis
thaliana) 		PF00168
(C2) 		5 LEU A 150
ALA A 115
ASP A 114
VAL A 179
LEU A 169
 None
 1.01A 3ogqA-5a51A:
undetectable		 3ogqA-5a51A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a5t EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT A
EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT F

(Oryctolagus
cuniculus) 		PF01398
(JAB)
PF01399
(PCI)
PF13012
(MitMem_reg) 		5 LEU F 328
ALA A 531
VAL F 335
GLY F 293
LEU F 331
 None
 0.99A 3ogqA-5a5tF:
undetectable		 3ogqA-5a5tF:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a87 METALLO-BETA-LACTAMA
SE VIM-5

(Klebsiella
pneumoniae) 		PF00753
(Lactamase_B) 		5 LEU A  96
ALA A  86
VAL A  44
ILE A  83
LEU A  95
 None
 1.00A 3ogqA-5a87A:
undetectable		 3ogqA-5a87A:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e25 BRANCHED-CHAIN
AMINOTRANSFERASE

(Geoglobus
acetivorans) 		PF01063
(Aminotran_4) 		5 LEU A 127
ILE A 258
VAL A 255
GLY A 186
LEU A 132
 None
 0.87A 3ogqA-5e25A:
undetectable		 3ogqA-5e25A:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		6 LEU A 614
ALA A 591
VAL A 606
MET A 556
GLY A 552
LEU A 610
 None
 1.06A 3ogqA-5e7pA:
undetectable		 3ogqA-5e7pA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4l ENVELOPE
GLYCOPROTEIN GP120
OF HIV-1 CLADE C

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU A 259
ILE A 284
VAL A 286
GLY A 346
LEU A 452
 None
 1.00A 3ogqA-5f4lA:
undetectable		 3ogqA-5f4lA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h53 SKELETAL MUSCLE
MYOSIN HEAVY CHAIN
MYHC-EO/IIL

(Oryctolagus
cuniculus) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		5 ALA A 263
ASP A 264
ILE A 265
GLY A 460
ILE A 459
 None
 0.91A 3ogqA-5h53A:
undetectable		 3ogqA-5h53A:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 LEU A  40
ALA A  31
ILE A  33
GLY A 127
ILE A 174
 None
GDP  A 501 ( 4.2A)
None
None
None
 0.95A 3ogqA-5h7kA:
undetectable		 3ogqA-5h7kA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 LEU A  79
ALA A 112
GLY A 175
ILE A 174
LEU A  81
 None
 0.99A 3ogqA-5h7wA:
undetectable		 3ogqA-5h7wA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 LEU A 333
ALA A 272
GLY A 303
ILE A 267
LEU A 336
 None
 1.00A 3ogqA-5j84A:
undetectable		 3ogqA-5j84A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jp6 PUTATIVE
POLYSACCHARIDE
DEACETYLASE

(Bdellovibrio
bacteriovorus) 		PF01522
(Polysacc_deac_1) 		5 LEU A  90
ALA A  84
GLY A  27
ILE A  26
LEU A  85
 None
 1.01A 3ogqA-5jp6A:
undetectable		 3ogqA-5jp6A:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kss 5'-NUCLEOTIDASE SURE

(Xylella
fastidiosa) 		PF01975
(SurE) 		5 LEU A 125
ALA A 144
ILE A 148
VAL A 165
GLY A 177
 None
 0.94A 3ogqA-5kssA:
undetectable		 3ogqA-5kssA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kzn METABOTROPIC
GLUTAMATE RECEPTOR 2

(Homo sapiens) 		PF01094
(ANF_receptor)
PF07562
(NCD3G) 		5 LEU A 278
ALA A 310
VAL A 304
GLY A 313
LEU A 279
 None
 0.84A 3ogqA-5kznA:
undetectable		 3ogqA-5kznA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 LEU B 289
ILE B 343
VAL B 340
GLY B 327
LEU B 315
 None
 0.92A 3ogqA-5l3rB:
undetectable		 3ogqA-5l3rB:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sx4 EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF01030
(Recep_L_domain) 		5 LEU M 368
VAL M 374
GLY M 315
ILE M 316
LEU M 371
 None
 0.87A 3ogqA-5sx4M:
undetectable		 3ogqA-5sx4M:
18.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5t2z PROTEASE

(Human
immunodeficiency
virus 1) 		PF00077
(RVP) 		7 LEU A  23
ASP A  25
ALA A  28
ASP A  29
VAL A  32
GLY A  49
ILE A  50
 None
 0.60A 3ogqA-5t2zA:
15.2		 3ogqA-5t2zA:
31.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5um8 GLYCOPROTEIN GP120

(Human
immunodeficiency
virus 1) 		PF00516
(GP120) 		5 LEU G 259
ILE G 284
VAL G 286
GLY G 346
LEU G 452
 None
 1.00A 3ogqA-5um8G:
undetectable		 3ogqA-5um8G:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		5 LEU A 316
ALA A 353
ILE A 334
VAL A 295
GLY A 326
 None
 0.92A 3ogqA-5uzeA:
undetectable		 3ogqA-5uzeA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens) 		PF02263
(GBP)
PF02841
(GBP_C) 		5 LEU A  31
ASP A  42
ALA A  45
ILE A  49
VAL A  27
 None
 1.00A 3ogqA-5vgrA:
undetectable		 3ogqA-5vgrA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 6 ALA A 260
ASP A 261
ILE A 262
VAL A 219
GLY A 457
ILE A 456
 None
 1.20A 3ogqA-5w1aA:
undetectable		 3ogqA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1a MYOSIN HEAVY CHAIN,
MUSCLE

(Drosophila
melanogaster) 		no annotation 6 ALA A 260
ASP A 261
VAL A 219
GLY A 457
ILE A 456
LEU A 215
 None
 1.09A 3ogqA-5w1aA:
undetectable		 3ogqA-5w1aA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c8z ADP-DEPENDENT
PHOSPHOFRUCTOKINASE

(Methanosarcinales) 		no annotation 5 ALA A 125
ILE A 129
VAL A 132
ILE A 119
LEU A 153
 None
 0.95A 3ogqA-6c8zA:
undetectable		 3ogqA-6c8zA:
14.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fiv RETROPEPSIN

(Feline
immunodeficiency
virus) 		PF00077
(RVP) 		8 LEU A  28
ASP A  30
ALA A  33
ASP A  34
ILE A  35
MET A  56
GLY A  58
LEU A 101
 None
3TL  A 201 (-3.5A)
3TL  A 201 (-4.0A)
3TL  A 201 (-3.9A)
3TL  A 201 ( 4.3A)
3TL  A 201 (-4.7A)
3TL  A 201 (-3.4A)
3TL  A 201 (-4.8A)
 0.52A 3ogqA-6fivA:
21.4		 3ogqA-6fivA:
95.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6upj HIV-2 PROTEASE

(Human
immunodeficiency
virus 2) 		PF00077
(RVP) 		6 LEU A  23
ASP A  25
ALA A  28
ASP A  29
GLY A  49
ILE A  50
 None
NIU  A 100 (-2.8A)
NIU  A 100 (-3.6A)
None
NIU  A 100 ( 3.8A)
NIU  A 100 (-3.9A)
 0.87A 3ogqA-6upjA:
15.4		 3ogqA-6upjA:
29.17