SIMILAR PATTERNS OF AMINO ACIDS FOR 3OG7_A_032A1_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18ALA A 31LYS A 33CYH A 83GLY A 146 | None | 1.14A | 3og7A-1h4lA:17.7 | 3og7A-1h4lA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18ALA A 31LYS A 33LEU A 55CYH A 83 | None | 0.88A | 3og7A-1h4lA:17.7 | 3og7A-1h4lA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1h4l | CELL DIVISIONPROTEIN KINASE 5 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18LYS A 33LEU A 55CYH A 83PHE A 145 | None | 1.07A | 3og7A-1h4lA:17.7 | 3og7A-1h4lA:23.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k2p | TYROSINE-PROTEINKINASE BTK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 416ALA A 428LYS A 430THR A 474PHE A 540GLY A 541 | None | 0.87A | 3og7A-1k2pA:22.7 | 3og7A-1k2pA:29.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k9a | CARBOXYL-TERMINALSRC KINASE (Rattusnorvegicus) |
PF00017(SH2)PF00018(SH3_1)PF07714(Pkinase_Tyr) | 6 | ILE A 201VAL A 209ALA A 220LYS A 222THR A 266GLY A 334 | None | 0.92A | 3og7A-1k9aA:28.0 | 3og7A-1k9aA:22.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1q8y | SR PROTEIN KINASE (Saccharomycescerevisiae) |
PF00069(Pkinase) | 5 | VAL A 172ALA A 185LYS A 187LEU A 206LEU A 226 | ADP A 810 (-4.1A)ADP A 810 (-3.3A)ADP A 810 (-3.1A)NoneADP A 810 (-4.4A) | 0.63A | 3og7A-1q8yA:21.0 | 3og7A-1q8yA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1snx | TYROSINE-PROTEINKINASE ITK/TSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 369VAL A 377ALA A 389LYS A 391PHE A 501 | None | 0.58A | 3og7A-1snxA:29.3 | 3og7A-1snxA:29.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 603ALA A 621LYS A 623LEU A 644THR A 670 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-4.4A)STI A 3 (-3.2A) | 0.74A | 3og7A-1t46A:26.9 | 3og7A-1t46A:30.41 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1t46 | HOMO SAPIENS V-KITHARDY-ZUCKERMAN 4FELINE SARCOMA VIRALONCOGENE HOMOLOG (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 603ALA A 621LYS A 623THR A 670CYH A 673 | STI A 3 ( 4.6A)STI A 3 (-3.5A)STI A 3 (-3.7A)STI A 3 (-3.2A)STI A 3 (-4.5A) | 0.35A | 3og7A-1t46A:26.9 | 3og7A-1t46A:30.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | ILE A 34VAL A 42ALA A 55LYS A 57CYH A 108GLY A 171 | None | 1.20A | 3og7A-1u5qA:24.5 | 3og7A-1u5qA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | ILE A 34VAL A 42ALA A 55LYS A 57CYH A 108PHE A 170 | None | 1.06A | 3og7A-1u5qA:24.5 | 3og7A-1u5qA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u5q | SERINE/THREONINEPROTEIN KINASE TAO2 (Rattusnorvegicus) |
PF00069(Pkinase) | 6 | VAL A 42ALA A 55LYS A 57LEU A 80CYH A 108PHE A 170 | None | 0.99A | 3og7A-1u5qA:24.5 | 3og7A-1u5qA:30.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zlt | SERINE/THREONINE-PROTEIN KINASE CHK1 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 23ALA A 36LYS A 38CYH A 87PHE A 149 | HYM A 400 (-4.3A)HYM A 400 (-3.5A)HYM A 400 (-3.2A)HYM A 400 (-4.2A)None | 0.74A | 3og7A-1zltA:22.0 | 3og7A-1zltA:25.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy4 | SERINE/THREONINE-PROTEIN KINASE GCN2 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | VAL A 613ALA A 626CYH A 791PHE A 842PHE A 854GLY A 855 | NoneGOL A 998 ( 3.7A)GOL A 998 (-4.3A)GOL A 998 ( 4.2A)NoneNone | 1.49A | 3og7A-1zy4A:21.9 | 3og7A-1zy4A:28.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zy4 | SERINE/THREONINE-PROTEIN KINASE GCN2 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 6 | VAL A 613ALA A 626LEU A 647CYH A 791PHE A 842PHE A 854 | NoneGOL A 998 ( 3.7A)NoneGOL A 998 (-4.3A)GOL A 998 ( 4.2A)None | 1.13A | 3og7A-1zy4A:21.9 | 3og7A-1zy4A:28.18 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2a1a | INTERFERON-INDUCED,DOUBLE-STRANDEDRNA-ACTIVATEDPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE B 273VAL B 281LYS B 296CYH B 369PHE B 421GLY B 434 | None | 1.06A | 3og7A-2a1aB:22.4 | 3og7A-2a1aB:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2a1a | INTERFERON-INDUCED,DOUBLE-STRANDEDRNA-ACTIVATEDPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE B 273VAL B 281LYS B 296CYH B 369PHE B 421PHE B 433 | None | 0.96A | 3og7A-2a1aB:22.4 | 3og7A-2a1aB:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2a1a | INTERFERON-INDUCED,DOUBLE-STRANDEDRNA-ACTIVATEDPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE B 273VAL B 281LYS B 296LEU B 312PHE B 421PHE B 433 | None | 1.22A | 3og7A-2a1aB:22.4 | 3og7A-2a1aB:30.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hen | EPHRIN TYPE-BRECEPTOR 2 (Mus musculus) |
PF07714(Pkinase_Tyr) | 6 | ILE A 635VAL A 643ALA A 659LYS A 661THR A 707PHE A 773 | ADP A 400 (-4.9A)ADP A 400 ( 4.4A)ADP A 400 (-3.2A)ADP A 400 (-2.7A)ADP A 400 (-4.7A)None | 1.11A | 3og7A-2henA:27.8 | 3og7A-2henA:31.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2hk5 | TYROSINE-PROTEINKINASE HCK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 259ALA A 271LYS A 273THR A 316PHE A 383 | 1BM A 499 ( 4.8A)1BM A 499 (-3.6A)1BM A 499 (-3.8A)1BM A 499 (-3.2A)None | 0.65A | 3og7A-2hk5A:27.0 | 3og7A-2hk5A:31.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hw6 | MAPKINASE-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 1 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 63ALA A 76LYS A 78LEU A 98LEU A 108PHE A 230 | None | 1.01A | 3og7A-2hw6A:20.9 | 3og7A-2hw6A:26.81 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 6 | ILE A 428VAL A 436ALA A 452LYS A 454CYH A 502GLY A 566 | 4ST A1687 (-4.2A)4ST A1687 ( 4.8A)4ST A1687 (-3.3A)4ST A1687 (-3.4A)4ST A1687 (-4.1A)None | 1.04A | 3og7A-2j0jA:28.7 | 3og7A-2j0jA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j0j | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF00373(FERM_M)PF07714(Pkinase_Tyr) | 6 | ILE A 428VAL A 436ALA A 452LYS A 454CYH A 502PHE A 565 | 4ST A1687 (-4.2A)4ST A1687 ( 4.8A)4ST A1687 (-3.3A)4ST A1687 (-3.4A)4ST A1687 (-4.1A)None | 1.01A | 3og7A-2j0jA:28.7 | 3og7A-2j0jA:18.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jgz | CELL DIVISIONPROTEIN KINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 6 | ILE A 10VAL A 18ALA A 31LYS A 33LEU A 55PHE A 146 | None | 1.18A | 3og7A-2jgzA:9.7 | 3og7A-2jgzA:25.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | ILE A 428VAL A 436ALA A 452LYS A 454CYH A 502GLY A 566 | BII A1687 (-3.8A)BII A1687 ( 4.7A)BII A1687 (-3.5A)BII A1687 (-2.9A)BII A1687 (-4.1A)None | 0.82A | 3og7A-2jkmA:28.4 | 3og7A-2jkmA:29.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jkm | FOCAL ADHESIONKINASE 1 (Gallus gallus) |
PF07714(Pkinase_Tyr) | 6 | ILE A 428VAL A 436ALA A 452LYS A 454CYH A 502PHE A 565 | BII A1687 (-3.8A)BII A1687 ( 4.7A)BII A1687 (-3.5A)BII A1687 (-2.9A)BII A1687 (-4.1A)None | 1.07A | 3og7A-2jkmA:28.4 | 3og7A-2jkmA:29.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ogv | MACROPHAGECOLONY-STIMULATINGFACTOR 1 RECEPTORPRECURSOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 596ALA A 614LYS A 616THR A 663CYH A 666 | None | 0.60A | 3og7A-2ogvA:25.2 | 3og7A-2ogvA:28.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qkw | PROTEIN KINASE (Solanumpimpinellifolium) |
PF07714(Pkinase_Tyr) | 6 | ILE B 47VAL B 55ALA B 67LYS B 69LEU B 89PHE B 183 | None | 1.23A | 3og7A-2qkwB:24.3 | 3og7A-2qkwB:28.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 204ALA A 215LYS A 217LEU A 245THR A 265GLY A 341 | ADE A 488 ( 4.9A)ADE A 488 (-3.2A)NoneADE A 488 ( 4.5A)ADE A 488 (-4.3A)None | 0.83A | 3og7A-2qluA:25.1 | 3og7A-2qluA:26.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlu | ACTIVIN RECEPTORTYPE IIB (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 204ALA A 215LYS A 217LEU A 245THR A 265PHE A 340 | ADE A 488 ( 4.9A)ADE A 488 (-3.2A)NoneADE A 488 ( 4.5A)ADE A 488 (-4.3A)None | 0.85A | 3og7A-2qluA:25.1 | 3og7A-2qluA:26.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r4b | RECEPTORTYROSINE-PROTEINKINASE ERBB-4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 732ALA A 749LYS A 751THR A 796PHE A 862 | GW7 A 1 ( 4.8A)GW7 A 1 (-3.3A)GW7 A 1 (-3.9A)GW7 A 1 (-4.0A)GW7 A 1 (-3.8A) | 0.73A | 3og7A-2r4bA:20.8 | 3og7A-2r4bA:33.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2w | WEE1-LIKE PROTEINKINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 305VAL A 313CYH A 379PHE A 433GLY A 465 | 770 A 901 (-3.8A)770 A 901 ( 4.7A)770 A 901 (-3.9A)770 A 901 (-4.0A)None | 0.73A | 3og7A-2z2wA:23.4 | 3og7A-2z2wA:28.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z2w | WEE1-LIKE PROTEINKINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 313ALA A 326CYH A 379PHE A 433GLY A 465 | 770 A 901 ( 4.7A)770 A 901 (-3.5A)770 A 901 (-3.9A)770 A 901 (-4.0A)None | 0.78A | 3og7A-2z2wA:23.4 | 3og7A-2z2wA:28.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2zv7 | TYROSINE-PROTEINKINASE LYN (Mus musculus) |
PF07714(Pkinase_Tyr) | 5 | VAL A 261ALA A 273LYS A 275THR A 319PHE A 386 | None | 0.71A | 3og7A-2zv7A:27.6 | 3og7A-2zv7A:34.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3d7u | TYROSINE-PROTEINKINASE CSK (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 201VAL A 209ALA A 220LYS A 222THR A 266GLY A 334 | None | 0.93A | 3og7A-3d7uA:23.1 | 3og7A-3d7uA:30.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3f3z | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE WITH A KINASEDOMAIN AND 4CALMODULIN LIKE EFHANDS (Cryptosporidiumparvum) |
PF00069(Pkinase) | 6 | ILE A 34VAL A 42ALA A 55LYS A 57CYH A 105PHE A 170 | DRK A 1 (-4.2A)DRK A 1 ( 4.9A)DRK A 1 (-3.4A)DRK A 1 (-4.1A)DRK A 1 (-4.1A)None | 1.02A | 3og7A-3f3zA:18.2 | 3og7A-3f3zA:25.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hng | VASCULAR ENDOTHELIALGROWTH FACTORRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 841ALA A 859LYS A 861LEU A 882CYH A 912 | 8ST A2001 ( 4.6A)8ST A2001 ( 3.8A)8ST A2001 (-4.0A)None8ST A2001 (-3.8A) | 0.68A | 3og7A-3hngA:26.6 | 3og7A-3hngA:27.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kul | EPHRIN TYPE-ARECEPTOR 8 (Homo sapiens) |
PF07714(Pkinase_Tyr)PF14575(EphA2_TM) | 5 | VAL A 649ALA A 665LYS A 667THR A 713PHE A 779 | None | 0.79A | 3og7A-3kulA:28.5 | 3og7A-3kulA:32.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lj0 | SERINE/THREONINE-PROTEINKINASE/ENDORIBONUCLEASE IRE1 (Saccharomycescerevisiae) |
PF00069(Pkinase)PF06479(Ribonuc_2-5A) | 5 | VAL A 689ALA A 700LYS A 702CYH A 748PHE A 829 | ADP A2101 (-4.5A)ADP A2101 (-3.5A)ADP A2101 (-2.7A)ADP A2101 (-4.2A)None | 0.77A | 3og7A-3lj0A:18.3 | 3og7A-3lj0A:24.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mdy | BONE MORPHOGENETICPROTEIN RECEPTORTYPE-1B (Homo sapiens) |
PF07714(Pkinase_Tyr)PF08515(TGF_beta_GS) | 5 | VAL A 218ALA A 229LYS A 231LEU A 259THR A 279 | LDN A 1 ( 4.8A)LDN A 1 (-3.6A)NoneNoneLDN A 1 (-3.8A) | 0.53A | 3og7A-3mdyA:24.8 | 3og7A-3mdyA:29.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mi9 | CELL DIVISIONPROTEIN KINASE 9 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 33ALA A 46LYS A 48LEU A 70CYH A 106PHE A 168 | None | 1.05A | 3og7A-3mi9A:16.8 | 3og7A-3mi9A:25.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3my0 | SERINE/THREONINE-PROTEIN KINASE RECEPTORR3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 216ALA A 227LYS A 229LEU A 257THR A 277 | LDN A 600 (-4.5A)LDN A 600 (-3.2A)LDN A 600 (-4.0A)NoneLDN A 600 (-4.0A) | 0.34A | 3og7A-3my0A:25.0 | 3og7A-3my0A:26.95 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 355VAL A 363ALA A 373LEU A 397LEU A 406THR A 421TRP A 423CYH A 424PHE A 475PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)None | 0.79A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 10 | ILE A 355VAL A 363ALA A 373LYS A 375LEU A 397LEU A 406THR A 421TRP A 423PHE A 475PHE A 487 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)NoneNoneSM5 A 1 (-4.4A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 0.81A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ILE A 355VAL A 363ALA A 373LYS A 375TRP A 423PHE A 475GLY A 488 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-3.5A)SM5 A 1 (-4.3A)SM5 A 1 (-3.0A)None | 1.05A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3omv | RAF PROTO-ONCOGENESERINE/THREONINE-PROTEIN KINASE (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | ILE A 355VAL A 363ALA A 373TRP A 423CYH A 424PHE A 475GLY A 488 | SM5 A 1 (-4.3A)SM5 A 1 (-4.0A)SM5 A 1 (-3.6A)SM5 A 1 (-4.3A)SM5 A 1 ( 4.4A)SM5 A 1 (-3.0A)None | 0.97A | 3og7A-3omvA:34.5 | 3og7A-3omvA:72.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ppz | SERINE/THREONINE-PROTEIN KINASE CTR1 (Arabidopsisthaliana) |
PF07714(Pkinase_Tyr) | 5 | VAL A 565ALA A 576LYS A 578THR A 625PHE A 695 | STU A 1 (-4.9A)STU A 1 (-3.3A)STU A 1 (-3.5A)STU A 1 (-4.1A)None | 0.77A | 3og7A-3ppzA:29.7 | 3og7A-3ppzA:38.98 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3q4t | ACTIVIN RECEPTORTYPE-2A (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 206ALA A 217LYS A 219LEU A 247THR A 267PHE A 341 | TAK A 2 ( 4.9A)TAK A 2 (-3.5A)TAK A 2 (-2.9A)NoneTAK A 2 (-3.5A)None | 0.82A | 3og7A-3q4tA:25.1 | 3og7A-3q4tA:30.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q5i | PROTEIN KINASE (Plasmodiumberghei) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | VAL A 71ALA A 84LYS A 86LEU A 119THR A 144PHE A 212 | ANP A1634 (-4.1A)ANP A1634 (-3.6A)ANP A1634 (-3.1A)NoneANP A1634 (-4.6A)None | 0.90A | 3og7A-3q5iA:21.6 | 3og7A-3q5iA:21.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q60 | ROP5B (Toxoplasmagondii) |
PF14531(Kinase-like) | 5 | VAL A 248ALA A 261LYS A 263LEU A 304PHE A 396 | ATP A 600 (-4.3A)ATP A 600 (-3.6A)MLI A 601 ( 2.8A)ATP A 600 ( 4.8A)ATP A 600 (-4.4A) | 0.61A | 3og7A-3q60A:18.6 | 3og7A-3q60A:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL B 603ALA B 616LYS B 618CYH B 889PHE B 942GLY B 955 | None | 0.90A | 3og7A-3qd2B:22.3 | 3og7A-3qd2B:26.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL B 603ALA B 616LYS B 618CYH B 889PHE B 942PHE B 954 | None | 0.77A | 3og7A-3qd2B:22.3 | 3og7A-3qd2B:26.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qd2 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL B 603ALA B 616LYS B 618LEU B 639PHE B 942PHE B 954 | None | 0.89A | 3og7A-3qd2B:22.3 | 3og7A-3qd2B:26.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 625VAL A 633ALA A 649LYS A 651THR A 697PHE A 763 | None | 0.97A | 3og7A-3zfxA:28.3 | 3og7A-3zfxA:32.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a4l | SERINE/THREONINE-PROTEIN KINASE PLK1 (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 80LYS A 82CYH A 133PHE A 183PHE A 195 | 939 A1331 (-3.5A)939 A1331 (-2.6A)939 A1331 (-4.0A)939 A1331 (-4.0A)None | 0.72A | 3og7A-4a4lA:18.3 | 3og7A-4a4lA:26.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4agu | CYCLIN-DEPENDENTKINASE-LIKE 1 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 18ALA A 31LYS A 33LEU A 55CYH A 83 | D15 A 500 (-4.6A)D15 A 500 (-3.4A)D15 A 500 ( 4.1A)NoneD15 A 500 (-4.3A) | 0.76A | 3og7A-4aguA:24.5 | 3og7A-4aguA:24.10 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4aw5 | EPHRIN TYPE-BRECEPTOR 4 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE A 97VAL A 105ALA A 121LYS A 123THR A 169PHE A 235 | 30K A1365 (-4.5A)30K A1365 ( 4.6A)30K A1365 (-3.2A)30K A1365 (-3.8A)30K A1365 (-3.8A)None | 1.01A | 3og7A-4aw5A:28.2 | 3og7A-4aw5A:32.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 5 | VAL A 222ALA A 233LYS A 235LEU A 263GLY A 356 | TAK A1507 (-4.7A)TAK A1507 (-3.3A)TAK A1507 ( 4.5A)FLC A1503 ( 4.5A)None | 0.73A | 3og7A-4c02A:25.0 | 3og7A-4c02A:28.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c02 | ACTIVIN RECEPTORTYPE-1 (Homo sapiens) |
PF00069(Pkinase)PF08515(TGF_beta_GS) | 5 | VAL A 222ALA A 233LYS A 235LEU A 263THR A 283 | TAK A1507 (-4.7A)TAK A1507 (-3.3A)TAK A1507 ( 4.5A)FLC A1503 ( 4.5A)TAK A1507 (-3.6A) | 0.32A | 3og7A-4c02A:25.0 | 3og7A-4c02A:28.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4c0t | LIKELY PROTEINKINASE (Candidaalbicans) |
PF00069(Pkinase) | 5 | VAL A 254ALA A 267LYS A 269LEU A 292PHE A 383 | None | 0.72A | 3og7A-4c0tA:22.4 | 3og7A-4c0tA:15.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e93 | TYROSINE-PROTEINKINASE FES/FPS (Homo sapiens) |
PF00017(SH2)PF07714(Pkinase_Tyr) | 6 | ILE A 567VAL A 575ALA A 588LYS A 590LEU A 611PHE A 702 | GUI A 901 (-4.0A)GUI A 901 (-4.5A)GUI A 901 (-3.4A)GUI A 901 (-2.8A)NoneNone | 1.29A | 3og7A-4e93A:29.1 | 3og7A-4e93A:27.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4euu | SERINE/THREONINE-PROTEIN KINASE TBK1 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 23ALA A 36LYS A 38LEU A 59CYH A 89 | BX7 A 401 ( 4.6A)BX7 A 401 (-3.4A)BX7 A 401 (-3.5A)NoneBX7 A 401 (-4.1A) | 0.77A | 3og7A-4euuA:17.2 | 3og7A-4euuA:26.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 606ALA A 619CYH A 890PHE A 943PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)924 A1101 (-3.9A)924 A1101 ( 4.2A)924 A1101 ( 4.4A)None | 0.84A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 606ALA A 619LYS A 621CYH A 890PHE A 955GLY A 956 | 924 A1101 ( 4.8A)924 A1101 (-3.5A)None924 A1101 (-3.9A)924 A1101 ( 4.4A)None | 0.79A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g34 | EUKARYOTICTRANSLATIONINITIATION FACTOR2-ALPHA KINASE 3 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 606LYS A 621LEU A 642CYH A 890PHE A 955GLY A 956 | 924 A1101 ( 4.8A)None924 A1101 (-3.9A)924 A1101 (-3.9A)924 A1101 ( 4.4A)None | 0.75A | 3og7A-4g34A:23.6 | 3og7A-4g34A:27.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j7b | POLO-LIKE KINASE (Danio rerio) |
PF00069(Pkinase) | 5 | ALA A 66LYS A 68CYH A 119PHE A 169PHE A 181 | None | 0.79A | 3og7A-4j7bA:24.2 | 3og7A-4j7bA:27.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jlc | SERINE/THREONINE-PROTEIN KINASE TBK1 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL A 23ALA A 36LYS A 38CYH A 89PHE A 158GLY A 159 | NoneSU6 A 701 (-3.4A)NoneSU6 A 701 (-3.8A)NoneNone | 0.71A | 3og7A-4jlcA:20.9 | 3og7A-4jlcA:18.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jxf | SERINE/THREONINE-PROTEIN KINASE PLK4 (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 26ALA A 39LYS A 41LEU A 73CYH A 92PHE A 155 | 631 A 301 (-4.6A)631 A 301 (-3.3A)631 A 301 (-2.7A)None631 A 301 (-4.5A)None | 0.86A | 3og7A-4jxfA:19.5 | 3og7A-4jxfA:26.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m69 | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 3 (Mus musculus) |
PF00069(Pkinase) | 6 | VAL A 36ALA A 49LYS A 51LEU A 74THR A 95PHE A 162 | ANP A 401 (-4.5A)ANP A 401 (-3.1A)ANP A 401 (-2.9A)NoneANP A 401 (-3.8A)None | 0.73A | 3og7A-4m69A:27.2 | 3og7A-4m69A:27.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o38 | CYCLIN-G-ASSOCIATEDKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 54ALA A 67LYS A 69THR A 123CYH A 126PHE A 192 | NoneSIN A 401 ( 3.7A)NoneNoneSIN A 401 (-4.3A)None | 0.67A | 3og7A-4o38A:20.9 | 3og7A-4o38A:26.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4tyh | MITOGEN-ACTIVATEDPROTEIN KINASE 14 (Mus musculus) |
PF00069(Pkinase) | 5 | VAL B 38ALA B 51LYS B 53LEU B 75THR B 106 | None39G B 401 (-3.5A)39G B 401 (-4.2A)39G B 401 (-4.3A)39G B 401 (-3.6A) | 0.70A | 3og7A-4tyhB:19.2 | 3og7A-4tyhB:25.91 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ueu | TYROSINE KINASE AS -A COMMON ANCESTOR OFSRC AND ABL (syntheticconstruct) |
PF07714(Pkinase_Tyr) | 5 | VAL A 22ALA A 35LYS A 37THR A 81PHE A 148 | ACP A1264 (-4.7A)ACP A1264 (-2.9A)NoneACP A1264 (-4.5A)None | 0.71A | 3og7A-4ueuA:27.9 | 3og7A-4ueuA:35.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4y93 | NON-SPECIFICPROTEIN-TYROSINEKINASE,NON-SPECIFICPROTEIN-TYROSINEKINASE (Bos taurus) |
PF00169(PH)PF00779(BTK)PF07714(Pkinase_Tyr) | 5 | VAL A 416ALA A 428LYS A 430THR A 474PHE A 540 | 746 A 702 ( 4.3A)746 A 702 (-2.4A)746 A 702 (-3.7A)746 A 702 (-3.7A)None | 0.69A | 3og7A-4y93A:28.9 | 3og7A-4y93A:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ysj | CALMODULIN-LIKEDOMAIN PROTEINKINASE (Eimeria tenella) |
PF00069(Pkinase)PF13499(EF-hand_7) | 6 | VAL A 42ALA A 55LYS A 57LEU A 80THR A 105PHE A 173 | ADP A 506 (-4.3A)ADP A 506 (-3.3A)ADP A 506 (-2.4A)NoneADP A 506 ( 4.6A)None | 0.97A | 3og7A-4ysjA:25.5 | 3og7A-4ysjA:22.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5a46 | FIBROBLAST GROWTHFACTOR RECEPTOR 1(FMS-RELATEDTYROSINE KINASE 2,PFEIFFER SYNDROME),ISOFORM CRA_B (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 492ALA A 512LYS A 514PHE A 642GLY A 643 | 38O A1769 (-4.5A)38O A1769 (-3.6A)38O A1769 ( 3.1A)EDO A1766 (-3.7A)EDO A1766 (-3.6A) | 0.70A | 3og7A-5a46A:27.0 | 3og7A-5a46A:27.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7a | TRAF2 ANDNCK-INTERACTINGPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 39ALA A 52LYS A 54LEU A 73PHE A 172 | VAL A 39 (-0.6A)ALA A 52 (-0.0A)LYS A 54 ( 0.0A)LEU A 73 ( 0.6A)PHE A 172 ( 1.3A) | 0.67A | 3og7A-5d7aA:25.5 | 3og7A-5d7aA:29.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e8y | TGF-BETA RECEPTORTYPE-2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | VAL A 258ALA A 275LYS A 277LEU A 305THR A 325PHE A 398 | STU A 601 (-4.0A)STU A 601 (-3.1A)STU A 601 (-2.4A)STU A 601 ( 3.8A)STU A 601 ( 3.7A)None | 0.81A | 3og7A-5e8yA:25.0 | 3og7A-5e8yA:27.84 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5fd2 | SERINE/THREONINE-PROTEIN KINASE B-RAF (Homo sapiens) |
PF07714(Pkinase_Tyr) | 12 | ILE A 463VAL A 471ALA A 481LYS A 483LEU A 505LEU A 514THR A 529TRP A 531CYH A 532PHE A 583PHE A 595GLY A 596 | 5XJ A 801 ( 4.7A)5XJ A 801 (-4.6A)5XJ A 801 (-3.1A)5XJ A 801 (-3.8A)5XJ A 801 (-3.8A)5XJ A 801 (-4.5A)5XJ A 801 (-3.4A)5XJ A 801 (-4.4A)5XJ A 801 (-4.6A)5XJ A 801 (-4.3A)5XJ A 801 (-3.7A)5XJ A 801 (-3.7A) | 0.57A | 3og7A-5fd2A:37.3 | 3og7A-5fd2A:90.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5grn | PLATELET-DERIVEDGROWTH FACTORRECEPTOR ALPHA (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 607ALA A 625LYS A 627THR A 674CYH A 677 | 748 A1001 ( 4.7A)748 A1001 (-3.7A)748 A1001 (-4.0A)748 A1001 (-3.2A)748 A1001 (-4.5A) | 0.38A | 3og7A-5grnA:26.9 | 3og7A-5grnA:28.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5hes | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE MLT (Homo sapiens) |
PF07714(Pkinase_Tyr) | 7 | VAL A 30ALA A 43LYS A 45LEU A 57THR A 82PHE A 152GLY A 153 | 032 A 401 (-4.4A)032 A 401 (-3.2A)032 A 401 (-4.4A)032 A 401 ( 4.7A)032 A 401 (-3.7A)032 A 401 (-4.1A)032 A 401 (-3.6A) | 0.60A | 3og7A-5hesA:26.8 | 3og7A-5hesA:31.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hor | HEPATOCYTE GROWTHFACTOR RECEPTOR (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A1092ALA A1108LEU A1140PHE A1223GLY A1224 | 63K A1401 (-4.9A)63K A1401 (-3.5A)NoneNoneNone | 0.54A | 3og7A-5horA:26.0 | 3og7A-5horA:29.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5j5t | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE KINASE3 (Homo sapiens) |
PF00069(Pkinase) | 5 | VAL A 30ALA A 43LYS A 45CYH A 93PHE A 155 | 6G2 A 901 ( 4.9A)6G2 A 901 (-3.2A)6G2 A 901 ( 3.9A)TPO A 145 (-4.1A)None | 0.74A | 3og7A-5j5tA:22.1 | 3og7A-5j5tA:25.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kkr | KINASE SUPPRESSOR OFRAS 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 6 | ILE B 672VAL B 680ALA B 690THR B 739CYH B 742PHE B 804 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-3.5A)6U7 B1001 (-3.8A) | 1.01A | 3og7A-5kkrB:17.0 | 3og7A-5kkrB:36.31 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5kkr | KINASE SUPPRESSOR OFRAS 2 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE B 672VAL B 680ALA B 690THR B 739PHE B 793 | 6U7 B1001 ( 4.8A)6U7 B1001 ( 4.3A)6U7 B1001 (-3.6A)6U7 B1001 (-4.0A)6U7 B1001 (-4.3A) | 0.71A | 3og7A-5kkrB:17.0 | 3og7A-5kkrB:36.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ko1 | MIXED LINEAGE KINASEDOMAIN-LIKE PROTEIN (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ALA A 228LYS A 230LEU A 263CYH A 286PHE A 350 | 6UY A 501 (-3.4A)6UY A 501 (-4.0A)None6UY A 501 (-4.3A)None | 0.79A | 3og7A-5ko1A:26.1 | 3og7A-5ko1A:26.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5l6o | EPHRIN TYPE-BRECEPTOR 3 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | ILE A 639VAL A 647ALA A 663LYS A 665THR A 711 | 6P6 A1001 (-4.0A)None6P6 A1001 (-3.3A)None6P6 A1001 (-3.5A) | 0.74A | 3og7A-5l6oA:26.8 | 3og7A-5l6oA:30.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2c | SERINE/THREONINE-PROTEIN KINASE WNK3 (Homo sapiens) |
PF00069(Pkinase)PF12202(OSR1_C) | 5 | VAL A 161ALA A 174LEU A 198THR A 227PHE A 282 | NoneGOL A 604 ( 3.8A)NoneGOL A 604 (-3.9A)GOL A 604 ( 4.5A) | 0.73A | 3og7A-5o2cA:26.3 | 3og7A-5o2cA:26.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tvt | MATERNAL EMBRYONICLEUCINE ZIPPERKINASE (Homo sapiens) |
no annotation | 5 | VAL A 25ALA A 38LYS A 40CYH A 89PHE A 151 | 7LV A 401 ( 4.6A)7LV A 401 (-3.4A)7LV A 401 (-3.0A)7LV A 401 (-4.3A)None | 0.79A | 3og7A-5tvtA:23.3 | 3og7A-5tvtA:26.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vcx | MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 124ALA A 137LYS A 139THR A 187CYH A 190GLY A 253 | H8H A 401 (-4.7A)H8H A 401 (-3.3A)H8H A 401 (-4.9A)H8H A 401 (-3.5A)H8H A 401 (-4.3A)None | 1.13A | 3og7A-5vcxA:18.1 | 3og7A-5vcxA:25.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vcx | MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 124ALA A 137THR A 187CYH A 190PHE A 240GLY A 253 | H8H A 401 (-4.7A)H8H A 401 (-3.3A)H8H A 401 (-3.5A)H8H A 401 (-4.3A)H8H A 401 (-4.3A)None | 0.67A | 3og7A-5vcxA:18.1 | 3og7A-5vcxA:25.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vcx | MEMBRANE-ASSOCIATEDTYROSINE- ANDTHREONINE-SPECIFICCDC2-INHIBITORYKINASE (Homo sapiens) |
PF00069(Pkinase) | 6 | VAL A 124ALA A 137THR A 187CYH A 190PHE A 240PHE A 252 | H8H A 401 (-4.7A)H8H A 401 (-3.3A)H8H A 401 (-3.5A)H8H A 401 (-4.3A)H8H A 401 (-4.3A)None | 0.83A | 3og7A-5vcxA:18.1 | 3og7A-5vcxA:25.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vdk | WEE1-LIKE PROTEINKINASE 2 (Homo sapiens) |
PF00069(Pkinase) | 5 | ILE A 218VAL A 226CYH A 292PHE A 346GLY A 382 | 8X7 A 501 ( 4.0A)8X7 A 501 ( 4.5A)8X7 A 501 (-3.8A)8X7 A 501 (-3.7A)None | 0.78A | 3og7A-5vdkA:22.7 | 3og7A-5vdkA:28.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vo1 | MITOGEN-ACTIVATEDPROTEIN KINASEKINASE KINASE 12 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | VAL A 139ALA A 150LYS A 152CYH A 193PHE A 255 | 9FS A 501 (-4.5A)9FS A 501 (-3.4A)None9FS A 501 (-4.3A)None | 0.74A | 3og7A-5vo1A:27.3 | 3og7A-5vo1A:37.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w5j | RECEPTOR-INTERACTINGSERINE/THREONINE-PROTEIN KINASE 2 (Homo sapiens) |
no annotation | 5 | VAL A 32ALA A 45LYS A 47LEU A 79THR A 95 | 9WS A 401 ( 4.6A)9WS A 401 (-3.3A)9WS A 401 (-3.3A)9WS A 401 (-4.9A)9WS A 401 (-3.2A) | 0.57A | 3og7A-5w5jA:26.7 | 3og7A-5w5jA:29.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wno | RECEPTORTYROSINE-PROTEINKINASE LET-23 (Caenorhabditiselegans) |
no annotation | 5 | VAL A 899ALA A 917LEU A 947THR A 963PHE A1029 | ANP A1201 (-4.4A)ANP A1201 (-3.3A)ANP A1201 (-4.7A)ANP A1201 (-3.9A)None | 0.54A | 3og7A-5wnoA:27.3 | 3og7A-5wnoA:11.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1t | PPKA-294 (Serratia sp.FS14) |
no annotation | 6 | ILE A 29VAL A 37ALA A 50LYS A 52LEU A 93THR A 118 | NoneADP A 401 ( 4.5A)ADP A 401 (-3.4A)NoneNoneADP A 401 (-4.1A) | 1.04A | 3og7A-5x1tA:21.8 | 3og7A-5x1tA:14.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ao5 | SERINE/THREONINE-PROTEIN KINASE 3 (Homo sapiens) |
no annotation | 5 | VAL A 41ALA A 54CYH A 102PHE A 165GLY A 166 | ANP A 501 (-4.4A)ANP A 501 ( 3.7A)ANP A 501 (-4.2A)NoneNone | 0.69A | 3og7A-6ao5A:24.5 | 3og7A-6ao5A:24.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b4w | DUAL SPECIFICITYPROTEIN KINASE TTK (Homo sapiens) |
no annotation | 5 | ILE A 531VAL A 539ALA A 551LYS A 553PHE A 665 | CQ7 A 801 (-3.6A)CQ7 A 801 ( 4.8A)CQ7 A 801 (-3.2A)CQ7 A 801 (-3.2A)None | 0.74A | 3og7A-6b4wA:23.9 | 3og7A-6b4wA:28.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bfn | INTERLEUKIN-1RECEPTOR-ASSOCIATEDKINASE 1 (Homo sapiens) |
no annotation | 6 | ILE A 218VAL A 226ALA A 237LYS A 239LEU A 263PHE A 359 | DL1 A 601 (-4.0A)NoneDL1 A 601 (-3.4A)DL1 A 601 ( 4.1A)NoneNone | 1.27A | 3og7A-6bfnA:24.6 | 3og7A-6bfnA:13.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cmj | CALCIUM/CALMODULIN-DEPENDENT PROTEINKINASE KINASE 2 (Homo sapiens) |
no annotation | 6 | ILE A 171VAL A 179ALA A 192LYS A 194LEU A 240PHE A 331 | F6J A 501 (-4.3A)F6J A 501 (-4.6A)F6J A 501 (-3.4A)F6J A 501 (-2.9A)NoneNone | 1.18A | 3og7A-6cmjA:17.9 | 3og7A-6cmjA:16.49 |