SIMILAR PATTERNS OF AMINO ACIDS FOR 3OG7_A_032A1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
ALA A  31
LYS A  33
CYH A  83
GLY A 146
None
1.14A 3og7A-1h4lA:
17.7
3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
ALA A  31
LYS A  33
LEU A  55
CYH A  83
None
0.88A 3og7A-1h4lA:
17.7
3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h4l CELL DIVISION
PROTEIN KINASE 5


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
LYS A  33
LEU A  55
CYH A  83
PHE A 145
None
1.07A 3og7A-1h4lA:
17.7
3og7A-1h4lA:
23.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 416
ALA A 428
LYS A 430
THR A 474
PHE A 540
GLY A 541
None
0.87A 3og7A-1k2pA:
22.7
3og7A-1k2pA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE


(Rattus
norvegicus)
PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr)
6 ILE A 201
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 334
None
0.92A 3og7A-1k9aA:
28.0
3og7A-1k9aA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q8y SR PROTEIN KINASE

(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
5 VAL A 172
ALA A 185
LYS A 187
LEU A 206
LEU A 226
ADP  A 810 (-4.1A)
ADP  A 810 (-3.3A)
ADP  A 810 (-3.1A)
None
ADP  A 810 (-4.4A)
0.63A 3og7A-1q8yA:
21.0
3og7A-1q8yA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snx TYROSINE-PROTEIN
KINASE ITK/TSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 369
VAL A 377
ALA A 389
LYS A 391
PHE A 501
None
0.58A 3og7A-1snxA:
29.3
3og7A-1snxA:
29.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 603
ALA A 621
LYS A 623
LEU A 644
THR A 670
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-4.4A)
STI  A   3 (-3.2A)
0.74A 3og7A-1t46A:
26.9
3og7A-1t46A:
30.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 603
ALA A 621
LYS A 623
THR A 670
CYH A 673
STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.2A)
STI  A   3 (-4.5A)
0.35A 3og7A-1t46A:
26.9
3og7A-1t46A:
30.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
6 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 108
GLY A 171
None
1.20A 3og7A-1u5qA:
24.5
3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
6 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 108
PHE A 170
None
1.06A 3og7A-1u5qA:
24.5
3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2


(Rattus
norvegicus)
PF00069
(Pkinase)
6 VAL A  42
ALA A  55
LYS A  57
LEU A  80
CYH A 108
PHE A 170
None
0.99A 3og7A-1u5qA:
24.5
3og7A-1u5qA:
30.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  23
ALA A  36
LYS A  38
CYH A  87
PHE A 149
HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
HYM  A 400 (-4.2A)
None
0.74A 3og7A-1zltA:
22.0
3og7A-1zltA:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 VAL A 613
ALA A 626
CYH A 791
PHE A 842
PHE A 854
GLY A 855
None
GOL  A 998 ( 3.7A)
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
None
1.49A 3og7A-1zy4A:
21.9
3og7A-1zy4A:
28.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
6 VAL A 613
ALA A 626
LEU A 647
CYH A 791
PHE A 842
PHE A 854
None
GOL  A 998 ( 3.7A)
None
GOL  A 998 (-4.3A)
GOL  A 998 ( 4.2A)
None
1.13A 3og7A-1zy4A:
21.9
3og7A-1zy4A:
28.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 ILE B 273
VAL B 281
LYS B 296
CYH B 369
PHE B 421
GLY B 434
None
1.06A 3og7A-2a1aB:
22.4
3og7A-2a1aB:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 ILE B 273
VAL B 281
LYS B 296
CYH B 369
PHE B 421
PHE B 433
None
0.96A 3og7A-2a1aB:
22.4
3og7A-2a1aB:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2a1a INTERFERON-INDUCED,
DOUBLE-STRANDED
RNA-ACTIVATED
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 ILE B 273
VAL B 281
LYS B 296
LEU B 312
PHE B 421
PHE B 433
None
1.22A 3og7A-2a1aB:
22.4
3og7A-2a1aB:
30.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2


(Mus musculus)
PF07714
(Pkinase_Tyr)
6 ILE A 635
VAL A 643
ALA A 659
LYS A 661
THR A 707
PHE A 773
ADP  A 400 (-4.9A)
ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
ADP  A 400 (-2.7A)
ADP  A 400 (-4.7A)
None
1.11A 3og7A-2henA:
27.8
3og7A-2henA:
31.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 259
ALA A 271
LYS A 273
THR A 316
PHE A 383
1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
0.65A 3og7A-2hk5A:
27.0
3og7A-2hk5A:
31.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hw6 MAP
KINASE-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 1


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  63
ALA A  76
LYS A  78
LEU A  98
LEU A 108
PHE A 230
None
1.01A 3og7A-2hw6A:
20.9
3og7A-2hw6A:
26.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
6 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 566
4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
1.04A 3og7A-2j0jA:
28.7
3og7A-2j0jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF00373
(FERM_M)
PF07714
(Pkinase_Tyr)
6 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
4ST  A1687 (-4.2A)
4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 (-4.1A)
None
1.01A 3og7A-2j0jA:
28.7
3og7A-2j0jA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgz CELL DIVISION
PROTEIN KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
6 ILE A  10
VAL A  18
ALA A  31
LYS A  33
LEU A  55
PHE A 146
None
1.18A 3og7A-2jgzA:
9.7
3og7A-2jgzA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
6 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
GLY A 566
BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
None
0.82A 3og7A-2jkmA:
28.4
3og7A-2jkmA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jkm FOCAL ADHESION
KINASE 1


(Gallus gallus)
PF07714
(Pkinase_Tyr)
6 ILE A 428
VAL A 436
ALA A 452
LYS A 454
CYH A 502
PHE A 565
BII  A1687 (-3.8A)
BII  A1687 ( 4.7A)
BII  A1687 (-3.5A)
BII  A1687 (-2.9A)
BII  A1687 (-4.1A)
None
1.07A 3og7A-2jkmA:
28.4
3og7A-2jkmA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 596
ALA A 614
LYS A 616
THR A 663
CYH A 666
None
0.60A 3og7A-2ogvA:
25.2
3og7A-2ogvA:
28.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qkw PROTEIN KINASE

(Solanum
pimpinellifolium)
PF07714
(Pkinase_Tyr)
6 ILE B  47
VAL B  55
ALA B  67
LYS B  69
LEU B  89
PHE B 183
None
1.23A 3og7A-2qkwB:
24.3
3og7A-2qkwB:
28.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
GLY A 341
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
0.83A 3og7A-2qluA:
25.1
3og7A-2qluA:
26.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qlu ACTIVIN RECEPTOR
TYPE IIB


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 204
ALA A 215
LYS A 217
LEU A 245
THR A 265
PHE A 340
ADE  A 488 ( 4.9A)
ADE  A 488 (-3.2A)
None
ADE  A 488 ( 4.5A)
ADE  A 488 (-4.3A)
None
0.85A 3og7A-2qluA:
25.1
3og7A-2qluA:
26.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 732
ALA A 749
LYS A 751
THR A 796
PHE A 862
GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
GW7  A   1 (-3.8A)
0.73A 3og7A-2r4bA:
20.8
3og7A-2r4bA:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 305
VAL A 313
CYH A 379
PHE A 433
GLY A 465
770  A 901 (-3.8A)
770  A 901 ( 4.7A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
0.73A 3og7A-2z2wA:
23.4
3og7A-2z2wA:
28.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2w WEE1-LIKE PROTEIN
KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A 313
ALA A 326
CYH A 379
PHE A 433
GLY A 465
770  A 901 ( 4.7A)
770  A 901 (-3.5A)
770  A 901 (-3.9A)
770  A 901 (-4.0A)
None
0.78A 3og7A-2z2wA:
23.4
3og7A-2z2wA:
28.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN


(Mus musculus)
PF07714
(Pkinase_Tyr)
5 VAL A 261
ALA A 273
LYS A 275
THR A 319
PHE A 386
None
0.71A 3og7A-2zv7A:
27.6
3og7A-2zv7A:
34.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 201
VAL A 209
ALA A 220
LYS A 222
THR A 266
GLY A 334
None
0.93A 3og7A-3d7uA:
23.1
3og7A-3d7uA:
30.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f3z CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS


(Cryptosporidium
parvum)
PF00069
(Pkinase)
6 ILE A  34
VAL A  42
ALA A  55
LYS A  57
CYH A 105
PHE A 170
DRK  A   1 (-4.2A)
DRK  A   1 ( 4.9A)
DRK  A   1 (-3.4A)
DRK  A   1 (-4.1A)
DRK  A   1 (-4.1A)
None
1.02A 3og7A-3f3zA:
18.2
3og7A-3f3zA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 841
ALA A 859
LYS A 861
LEU A 882
CYH A 912
8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
None
8ST  A2001 (-3.8A)
0.68A 3og7A-3hngA:
26.6
3og7A-3hngA:
27.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM)
5 VAL A 649
ALA A 665
LYS A 667
THR A 713
PHE A 779
None
0.79A 3og7A-3kulA:
28.5
3og7A-3kulA:
32.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lj0 SERINE/THREONINE-PRO
TEIN
KINASE/ENDORIBONUCLE
ASE IRE1


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
5 VAL A 689
ALA A 700
LYS A 702
CYH A 748
PHE A 829
ADP  A2101 (-4.5A)
ADP  A2101 (-3.5A)
ADP  A2101 (-2.7A)
ADP  A2101 (-4.2A)
None
0.77A 3og7A-3lj0A:
18.3
3og7A-3lj0A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS)
5 VAL A 218
ALA A 229
LYS A 231
LEU A 259
THR A 279
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
0.53A 3og7A-3mdyA:
24.8
3og7A-3mdyA:
29.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mi9 CELL DIVISION
PROTEIN KINASE 9


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  33
ALA A  46
LYS A  48
LEU A  70
CYH A 106
PHE A 168
None
1.05A 3og7A-3mi9A:
16.8
3og7A-3mi9A:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 216
ALA A 227
LYS A 229
LEU A 257
THR A 277
LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
0.34A 3og7A-3my0A:
25.0
3og7A-3my0A:
26.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ILE A 355
VAL A 363
ALA A 373
LEU A 397
LEU A 406
THR A 421
TRP A 423
CYH A 424
PHE A 475
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
0.79A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
10 ILE A 355
VAL A 363
ALA A 373
LYS A 375
LEU A 397
LEU A 406
THR A 421
TRP A 423
PHE A 475
PHE A 487
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
None
None
SM5  A   1 (-4.4A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
0.81A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A 355
VAL A 363
ALA A 373
LYS A 375
TRP A 423
PHE A 475
GLY A 488
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-3.5A)
SM5  A   1 (-4.3A)
SM5  A   1 (-3.0A)
None
1.05A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3omv RAF PROTO-ONCOGENE
SERINE/THREONINE-PRO
TEIN KINASE


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 ILE A 355
VAL A 363
ALA A 373
TRP A 423
CYH A 424
PHE A 475
GLY A 488
SM5  A   1 (-4.3A)
SM5  A   1 (-4.0A)
SM5  A   1 (-3.6A)
SM5  A   1 (-4.3A)
SM5  A   1 ( 4.4A)
SM5  A   1 (-3.0A)
None
0.97A 3og7A-3omvA:
34.5
3og7A-3omvA:
72.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1


(Arabidopsis
thaliana)
PF07714
(Pkinase_Tyr)
5 VAL A 565
ALA A 576
LYS A 578
THR A 625
PHE A 695
STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
None
0.77A 3og7A-3ppzA:
29.7
3og7A-3ppzA:
38.98
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3q4t ACTIVIN RECEPTOR
TYPE-2A


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 206
ALA A 217
LYS A 219
LEU A 247
THR A 267
PHE A 341
TAK  A   2 ( 4.9A)
TAK  A   2 (-3.5A)
TAK  A   2 (-2.9A)
None
TAK  A   2 (-3.5A)
None
0.82A 3og7A-3q4tA:
25.1
3og7A-3q4tA:
30.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q5i PROTEIN KINASE

(Plasmodium
berghei)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 VAL A  71
ALA A  84
LYS A  86
LEU A 119
THR A 144
PHE A 212
ANP  A1634 (-4.1A)
ANP  A1634 (-3.6A)
ANP  A1634 (-3.1A)
None
ANP  A1634 (-4.6A)
None
0.90A 3og7A-3q5iA:
21.6
3og7A-3q5iA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q60 ROP5B

(Toxoplasma
gondii)
PF14531
(Kinase-like)
5 VAL A 248
ALA A 261
LYS A 263
LEU A 304
PHE A 396
ATP  A 600 (-4.3A)
ATP  A 600 (-3.6A)
MLI  A 601 ( 2.8A)
ATP  A 600 ( 4.8A)
ATP  A 600 (-4.4A)
0.61A 3og7A-3q60A:
18.6
3og7A-3q60A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
GLY B 955
None
0.90A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL B 603
ALA B 616
LYS B 618
CYH B 889
PHE B 942
PHE B 954
None
0.77A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd2 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL B 603
ALA B 616
LYS B 618
LEU B 639
PHE B 942
PHE B 954
None
0.89A 3og7A-3qd2B:
22.3
3og7A-3qd2B:
26.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3zfx EPHRIN TYPE-B
RECEPTOR 1


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A 625
VAL A 633
ALA A 649
LYS A 651
THR A 697
PHE A 763
None
0.97A 3og7A-3zfxA:
28.3
3og7A-3zfxA:
32.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4l SERINE/THREONINE-PRO
TEIN KINASE PLK1


(Homo sapiens)
PF00069
(Pkinase)
5 ALA A  80
LYS A  82
CYH A 133
PHE A 183
PHE A 195
939  A1331 (-3.5A)
939  A1331 (-2.6A)
939  A1331 (-4.0A)
939  A1331 (-4.0A)
None
0.72A 3og7A-4a4lA:
18.3
3og7A-4a4lA:
26.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4agu CYCLIN-DEPENDENT
KINASE-LIKE 1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  18
ALA A  31
LYS A  33
LEU A  55
CYH A  83
D15  A 500 (-4.6A)
D15  A 500 (-3.4A)
D15  A 500 ( 4.1A)
None
D15  A 500 (-4.3A)
0.76A 3og7A-4aguA:
24.5
3og7A-4aguA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4aw5 EPHRIN TYPE-B
RECEPTOR 4


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE A  97
VAL A 105
ALA A 121
LYS A 123
THR A 169
PHE A 235
30K  A1365 (-4.5A)
30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
30K  A1365 (-3.8A)
None
1.01A 3og7A-4aw5A:
28.2
3og7A-4aw5A:
32.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
5 VAL A 222
ALA A 233
LYS A 235
LEU A 263
GLY A 356
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
None
0.73A 3og7A-4c02A:
25.0
3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1


(Homo sapiens)
PF00069
(Pkinase)
PF08515
(TGF_beta_GS)
5 VAL A 222
ALA A 233
LYS A 235
LEU A 263
THR A 283
TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
FLC  A1503 ( 4.5A)
TAK  A1507 (-3.6A)
0.32A 3og7A-4c02A:
25.0
3og7A-4c02A:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE


(Candida
albicans)
PF00069
(Pkinase)
5 VAL A 254
ALA A 267
LYS A 269
LEU A 292
PHE A 383
None
0.72A 3og7A-4c0tA:
22.4
3og7A-4c0tA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e93 TYROSINE-PROTEIN
KINASE FES/FPS


(Homo sapiens)
PF00017
(SH2)
PF07714
(Pkinase_Tyr)
6 ILE A 567
VAL A 575
ALA A 588
LYS A 590
LEU A 611
PHE A 702
GUI  A 901 (-4.0A)
GUI  A 901 (-4.5A)
GUI  A 901 (-3.4A)
GUI  A 901 (-2.8A)
None
None
1.29A 3og7A-4e93A:
29.1
3og7A-4e93A:
27.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4euu SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  23
ALA A  36
LYS A  38
LEU A  59
CYH A  89
BX7  A 401 ( 4.6A)
BX7  A 401 (-3.4A)
BX7  A 401 (-3.5A)
None
BX7  A 401 (-4.1A)
0.77A 3og7A-4euuA:
17.2
3og7A-4euuA:
26.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 606
ALA A 619
CYH A 890
PHE A 943
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
924  A1101 (-3.9A)
924  A1101 ( 4.2A)
924  A1101 ( 4.4A)
None
0.84A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 606
ALA A 619
LYS A 621
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
924  A1101 (-3.5A)
None
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.79A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g34 EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 606
LYS A 621
LEU A 642
CYH A 890
PHE A 955
GLY A 956
924  A1101 ( 4.8A)
None
924  A1101 (-3.9A)
924  A1101 (-3.9A)
924  A1101 ( 4.4A)
None
0.75A 3og7A-4g34A:
23.6
3og7A-4g34A:
27.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7b POLO-LIKE KINASE

(Danio rerio)
PF00069
(Pkinase)
5 ALA A  66
LYS A  68
CYH A 119
PHE A 169
PHE A 181
None
0.79A 3og7A-4j7bA:
24.2
3og7A-4j7bA:
27.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlc SERINE/THREONINE-PRO
TEIN KINASE TBK1


(Mus musculus)
PF00069
(Pkinase)
6 VAL A  23
ALA A  36
LYS A  38
CYH A  89
PHE A 158
GLY A 159
None
SU6  A 701 (-3.4A)
None
SU6  A 701 (-3.8A)
None
None
0.71A 3og7A-4jlcA:
20.9
3og7A-4jlcA:
18.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxf SERINE/THREONINE-PRO
TEIN KINASE PLK4


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  26
ALA A  39
LYS A  41
LEU A  73
CYH A  92
PHE A 155
631  A 301 (-4.6A)
631  A 301 (-3.3A)
631  A 301 (-2.7A)
None
631  A 301 (-4.5A)
None
0.86A 3og7A-4jxfA:
19.5
3og7A-4jxfA:
26.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m69 RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 3


(Mus musculus)
PF00069
(Pkinase)
6 VAL A  36
ALA A  49
LYS A  51
LEU A  74
THR A  95
PHE A 162
ANP  A 401 (-4.5A)
ANP  A 401 (-3.1A)
ANP  A 401 (-2.9A)
None
ANP  A 401 (-3.8A)
None
0.73A 3og7A-4m69A:
27.2
3og7A-4m69A:
27.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A  54
ALA A  67
LYS A  69
THR A 123
CYH A 126
PHE A 192
None
SIN  A 401 ( 3.7A)
None
None
SIN  A 401 (-4.3A)
None
0.67A 3og7A-4o38A:
20.9
3og7A-4o38A:
26.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tyh MITOGEN-ACTIVATED
PROTEIN KINASE 14


(Mus musculus)
PF00069
(Pkinase)
5 VAL B  38
ALA B  51
LYS B  53
LEU B  75
THR B 106
None
39G  B 401 (-3.5A)
39G  B 401 (-4.2A)
39G  B 401 (-4.3A)
39G  B 401 (-3.6A)
0.70A 3og7A-4tyhB:
19.2
3og7A-4tyhB:
25.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL


(synthetic
construct)
PF07714
(Pkinase_Tyr)
5 VAL A  22
ALA A  35
LYS A  37
THR A  81
PHE A 148
ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
ACP  A1264 (-4.5A)
None
0.71A 3og7A-4ueuA:
27.9
3og7A-4ueuA:
35.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE


(Bos taurus)
PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr)
5 VAL A 416
ALA A 428
LYS A 430
THR A 474
PHE A 540
746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-3.7A)
None
0.69A 3og7A-4y93A:
28.9
3og7A-4y93A:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysj CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE


(Eimeria tenella)
PF00069
(Pkinase)
PF13499
(EF-hand_7)
6 VAL A  42
ALA A  55
LYS A  57
LEU A  80
THR A 105
PHE A 173
ADP  A 506 (-4.3A)
ADP  A 506 (-3.3A)
ADP  A 506 (-2.4A)
None
ADP  A 506 ( 4.6A)
None
0.97A 3og7A-4ysjA:
25.5
3og7A-4ysjA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 492
ALA A 512
LYS A 514
PHE A 642
GLY A 643
38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-3.7A)
EDO  A1766 (-3.6A)
0.70A 3og7A-5a46A:
27.0
3og7A-5a46A:
27.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d7a TRAF2 AND
NCK-INTERACTING
PROTEIN KINASE


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  39
ALA A  52
LYS A  54
LEU A  73
PHE A 172
VAL  A  39 (-0.6A)
ALA  A  52 (-0.0A)
LYS  A  54 ( 0.0A)
LEU  A  73 ( 0.6A)
PHE  A 172 ( 1.3A)
0.67A 3og7A-5d7aA:
25.5
3og7A-5d7aA:
29.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 VAL A 258
ALA A 275
LYS A 277
LEU A 305
THR A 325
PHE A 398
STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
None
0.81A 3og7A-5e8yA:
25.0
3og7A-5e8yA:
27.84
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fd2 SERINE/THREONINE-PRO
TEIN KINASE B-RAF


(Homo sapiens)
PF07714
(Pkinase_Tyr)
12 ILE A 463
VAL A 471
ALA A 481
LYS A 483
LEU A 505
LEU A 514
THR A 529
TRP A 531
CYH A 532
PHE A 583
PHE A 595
GLY A 596
5XJ  A 801 ( 4.7A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-3.1A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-3.8A)
5XJ  A 801 (-4.5A)
5XJ  A 801 (-3.4A)
5XJ  A 801 (-4.4A)
5XJ  A 801 (-4.6A)
5XJ  A 801 (-4.3A)
5XJ  A 801 (-3.7A)
5XJ  A 801 (-3.7A)
0.57A 3og7A-5fd2A:
37.3
3og7A-5fd2A:
90.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 607
ALA A 625
LYS A 627
THR A 674
CYH A 677
748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.2A)
748  A1001 (-4.5A)
0.38A 3og7A-5grnA:
26.9
3og7A-5grnA:
28.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5hes MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT


(Homo sapiens)
PF07714
(Pkinase_Tyr)
7 VAL A  30
ALA A  43
LYS A  45
LEU A  57
THR A  82
PHE A 152
GLY A 153
032  A 401 (-4.4A)
032  A 401 (-3.2A)
032  A 401 (-4.4A)
032  A 401 ( 4.7A)
032  A 401 (-3.7A)
032  A 401 (-4.1A)
032  A 401 (-3.6A)
0.60A 3og7A-5hesA:
26.8
3og7A-5hesA:
31.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hor HEPATOCYTE GROWTH
FACTOR RECEPTOR


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A1092
ALA A1108
LEU A1140
PHE A1223
GLY A1224
63K  A1401 (-4.9A)
63K  A1401 (-3.5A)
None
None
None
0.54A 3og7A-5horA:
26.0
3og7A-5horA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3


(Homo sapiens)
PF00069
(Pkinase)
5 VAL A  30
ALA A  43
LYS A  45
CYH A  93
PHE A 155
6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
TPO  A 145 (-4.1A)
None
0.74A 3og7A-5j5tA:
22.1
3og7A-5j5tA:
25.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
6 ILE B 672
VAL B 680
ALA B 690
THR B 739
CYH B 742
PHE B 804
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-3.5A)
6U7  B1001 (-3.8A)
1.01A 3og7A-5kkrB:
17.0
3og7A-5kkrB:
36.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5kkr KINASE SUPPRESSOR OF
RAS 2


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE B 672
VAL B 680
ALA B 690
THR B 739
PHE B 793
6U7  B1001 ( 4.8A)
6U7  B1001 ( 4.3A)
6U7  B1001 (-3.6A)
6U7  B1001 (-4.0A)
6U7  B1001 (-4.3A)
0.71A 3og7A-5kkrB:
17.0
3og7A-5kkrB:
36.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ko1 MIXED LINEAGE KINASE
DOMAIN-LIKE PROTEIN


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ALA A 228
LYS A 230
LEU A 263
CYH A 286
PHE A 350
6UY  A 501 (-3.4A)
6UY  A 501 (-4.0A)
None
6UY  A 501 (-4.3A)
None
0.79A 3og7A-5ko1A:
26.1
3og7A-5ko1A:
26.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 ILE A 639
VAL A 647
ALA A 663
LYS A 665
THR A 711
6P6  A1001 (-4.0A)
None
6P6  A1001 (-3.3A)
None
6P6  A1001 (-3.5A)
0.74A 3og7A-5l6oA:
26.8
3og7A-5l6oA:
30.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o2c SERINE/THREONINE-PRO
TEIN KINASE WNK3


(Homo sapiens)
PF00069
(Pkinase)
PF12202
(OSR1_C)
5 VAL A 161
ALA A 174
LEU A 198
THR A 227
PHE A 282
None
GOL  A 604 ( 3.8A)
None
GOL  A 604 (-3.9A)
GOL  A 604 ( 4.5A)
0.73A 3og7A-5o2cA:
26.3
3og7A-5o2cA:
26.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE


(Homo sapiens)
no annotation 5 VAL A  25
ALA A  38
LYS A  40
CYH A  89
PHE A 151
7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-4.3A)
None
0.79A 3og7A-5tvtA:
23.3
3og7A-5tvtA:
26.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 124
ALA A 137
LYS A 139
THR A 187
CYH A 190
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-4.9A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
None
1.13A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
GLY A 253
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.67A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vcx MEMBRANE-ASSOCIATED
TYROSINE- AND
THREONINE-SPECIFIC
CDC2-INHIBITORY
KINASE


(Homo sapiens)
PF00069
(Pkinase)
6 VAL A 124
ALA A 137
THR A 187
CYH A 190
PHE A 240
PHE A 252
H8H  A 401 (-4.7A)
H8H  A 401 (-3.3A)
H8H  A 401 (-3.5A)
H8H  A 401 (-4.3A)
H8H  A 401 (-4.3A)
None
0.83A 3og7A-5vcxA:
18.1
3og7A-5vcxA:
25.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vdk WEE1-LIKE PROTEIN
KINASE 2


(Homo sapiens)
PF00069
(Pkinase)
5 ILE A 218
VAL A 226
CYH A 292
PHE A 346
GLY A 382
8X7  A 501 ( 4.0A)
8X7  A 501 ( 4.5A)
8X7  A 501 (-3.8A)
8X7  A 501 (-3.7A)
None
0.78A 3og7A-5vdkA:
22.7
3og7A-5vdkA:
28.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vo1 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 12


(Homo sapiens)
PF07714
(Pkinase_Tyr)
5 VAL A 139
ALA A 150
LYS A 152
CYH A 193
PHE A 255
9FS  A 501 (-4.5A)
9FS  A 501 (-3.4A)
None
9FS  A 501 (-4.3A)
None
0.74A 3og7A-5vo1A:
27.3
3og7A-5vo1A:
37.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2


(Homo sapiens)
no annotation 5 VAL A  32
ALA A  45
LYS A  47
LEU A  79
THR A  95
9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.3A)
9WS  A 401 (-4.9A)
9WS  A 401 (-3.2A)
0.57A 3og7A-5w5jA:
26.7
3og7A-5w5jA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23


(Caenorhabditis
elegans)
no annotation 5 VAL A 899
ALA A 917
LEU A 947
THR A 963
PHE A1029
ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-4.7A)
ANP  A1201 (-3.9A)
None
0.54A 3og7A-5wnoA:
27.3
3og7A-5wnoA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x1t PPKA-294

(Serratia sp.
FS14)
no annotation 6 ILE A  29
VAL A  37
ALA A  50
LYS A  52
LEU A  93
THR A 118
None
ADP  A 401 ( 4.5A)
ADP  A 401 (-3.4A)
None
None
ADP  A 401 (-4.1A)
1.04A 3og7A-5x1tA:
21.8
3og7A-5x1tA:
14.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3


(Homo sapiens)
no annotation 5 VAL A  41
ALA A  54
CYH A 102
PHE A 165
GLY A 166
ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-4.2A)
None
None
0.69A 3og7A-6ao5A:
24.5
3og7A-6ao5A:
24.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4w DUAL SPECIFICITY
PROTEIN KINASE TTK


(Homo sapiens)
no annotation 5 ILE A 531
VAL A 539
ALA A 551
LYS A 553
PHE A 665
CQ7  A 801 (-3.6A)
CQ7  A 801 ( 4.8A)
CQ7  A 801 (-3.2A)
CQ7  A 801 (-3.2A)
None
0.74A 3og7A-6b4wA:
23.9
3og7A-6b4wA:
28.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfn INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 1


(Homo sapiens)
no annotation 6 ILE A 218
VAL A 226
ALA A 237
LYS A 239
LEU A 263
PHE A 359
DL1  A 601 (-4.0A)
None
DL1  A 601 (-3.4A)
DL1  A 601 ( 4.1A)
None
None
1.27A 3og7A-6bfnA:
24.6
3og7A-6bfnA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cmj CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE KINASE 2


(Homo sapiens)
no annotation 6 ILE A 171
VAL A 179
ALA A 192
LYS A 194
LEU A 240
PHE A 331
F6J  A 501 (-4.3A)
F6J  A 501 (-4.6A)
F6J  A 501 (-3.4A)
F6J  A 501 (-2.9A)
None
None
1.18A 3og7A-6cmjA:
17.9
3og7A-6cmjA:
16.49