SIMILAR PATTERNS OF AMINO ACIDS FOR 3OEZ_B_STIB601

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.58A 3oezB-1k9aA:
31.2		 3oezB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.60A 3oezB-1k9aA:
31.2		 3oezB-1k9aA:
30.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 588
ALA A 606
LYS A 608
MET A 629
TYR A 656
LEU A 731
ALA A 741
ASP A 742
 None
 1.19A 3oezB-1lufA:
27.6		 3oezB-1lufA:
32.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 ALA A 288
LYS A 290
GLU A 305
VAL A 308
MET A 309
ILE A 332
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.66A 3oezB-1opkA:
31.4		 3oezB-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 275
ALA A 288
LYS A 290
VAL A 308
MET A 309
ILE A 332
THR A 334
LEU A 389
ALA A 399
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
None
P16  A   2 (-3.3A)
P16  A   2 (-4.1A)
P16  A   2 (-3.7A)
P16  A   2 (-4.4A)
P16  A   2 (-3.5A)
 0.67A 3oezB-1opkA:
31.4		 3oezB-1opkA:
30.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 621
GLU A 640
VAL A 643
THR A 670
TYR A 672
LEU A 799
ASP A 810
 STI  A   3 (-3.5A)
STI  A   3 (-3.6A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.56A 3oezB-1t46A:
31.9		 3oezB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
LYS A 623
VAL A 643
THR A 670
TYR A 672
LEU A 799
ASP A 810
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
None
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 (-4.4A)
STI  A   3 (-3.9A)
 0.81A 3oezB-1t46A:
31.9		 3oezB-1t46A:
35.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
GLU X  54
MET X  58
ILE X  80
THR X  82
TYR X  84
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.59A 3oezB-2dq7X:
35.4		 3oezB-2dq7X:
84.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL X  25
ALA X  37
LYS X  39
MET X  58
ILE X  80
THR X  82
TYR X  84
LEU X 137
ALA X 147
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
None
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
STU  X 902 (-4.4A)
STU  X 902 ( 4.1A)
 0.57A 3oezB-2dq7X:
35.4		 3oezB-2dq7X:
84.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
GLU A 201
VAL A 204
ILE A 234
LEU A 290
ALA A 319
 None
 0.74A 3oezB-2eu9A:
22.2		 3oezB-2eu9A:
25.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eu9 DUAL SPECIFICITY
PROTEIN KINASE CLK3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 170
ALA A 184
LYS A 186
VAL A 204
ILE A 234
LEU A 290
ALA A 319
 None
 0.85A 3oezB-2eu9A:
22.2		 3oezB-2eu9A:
25.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
TYR A 340
LEU A 393
ALA A 403
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 ( 4.5A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
H8H  A 534 (-4.5A)
H8H  A 534 ( 4.0A)
 0.56A 3oezB-2h8hA:
34.4		 3oezB-2h8hA:
52.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hck HEMATOPOETIC CELL
KINASE HCK

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
ILE A 336
THR A 338
LEU A 393
ALA A 403
 QUE  A   1 ( 4.8A)
QUE  A   1 (-3.5A)
None
None
QUE  A   1 (-3.3A)
QUE  A   1 (-4.4A)
QUE  A   1 ( 4.5A)
 0.74A 3oezB-2hckA:
32.7		 3oezB-2hckA:
50.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 643
ALA A 659
MET A 682
ILE A 705
THR A 707
LEU A 761
ASP A 772
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
ADP  A 400 ( 4.7A)
ADP  A 400 ( 4.8A)
 0.88A 3oezB-2henA:
27.6		 3oezB-2henA:
42.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
GLU A 288
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ASP A 382
 1BM  A 499 (-3.6A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 (-4.4A)
 0.92A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 271
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ALA A 381
ASP A 382
 1BM  A 499 (-3.6A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
1BM  A 499 (-4.4A)
 0.91A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
GLU A 288
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
 0.60A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
VAL A 291
MET A 292
ILE A 314
THR A 316
LEU A 371
ALA A 381
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
None
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.9A)
1BM  A 499 (-3.2A)
1BM  A 499 (-4.4A)
1BM  A 499 ( 3.7A)
 0.57A 3oezB-2hk5A:
27.7		 3oezB-2hk5A:
66.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
GLU A 286
VAL A 289
MET A 290
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.56A 3oezB-2hz0A:
31.8		 3oezB-2hz0A:
48.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 ALA A 269
LYS A 271
GLU A 286
VAL A 289
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.76A 3oezB-2hz0A:
31.8		 3oezB-2hz0A:
48.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 GLU A 286
MET A 290
ILE A 313
THR A 315
LEU A 370
ALA A 380
ASP A 381
 GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-4.9A)
 0.80A 3oezB-2hz0A:
31.8		 3oezB-2hz0A:
48.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 256
ALA A 269
LYS A 271
VAL A 289
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
None
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.72A 3oezB-2hz0A:
31.8		 3oezB-2hz0A:
48.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 256
ALA A 269
VAL A 289
MET A 290
ILE A 313
THR A 315
LEU A 370
ALA A 380
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
None
GIN  A 600 (-3.2A)
GIN  A 600 (-3.8A)
GIN  A 600 (-3.4A)
GIN  A 600 (-4.7A)
GIN  A 600 (-3.1A)
 0.59A 3oezB-2hz0A:
31.8		 3oezB-2hz0A:
48.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 356
ALA A 369
LYS A 371
GLU A 390
VAL A 393
TYR A 422
ALA A 483
 PDS  A 901 (-4.2A)
PDS  A 901 (-3.3A)
PDS  A 901 ( 4.5A)
None
None
PDS  A 901 (-4.7A)
PDS  A 901 (-3.4A)
 0.91A 3oezB-2i0eA:
13.2		 3oezB-2i0eA:
25.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
GLU A 288
MET A 292
ILE A 314
THR A 316
TYR A 318
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 0.87A 3oezB-2og8A:
36.0		 3oezB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
ILE A 314
TYR A 318
LEU A 371
ALA A 381
ASP A 382
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 4.6A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.3A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.3A)
 1.00A 3oezB-2og8A:
36.0		 3oezB-2og8A:
67.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 596
ALA A 614
GLU A 633
MET A 637
THR A 663
TYR A 665
LEU A 785
 None
 0.82A 3oezB-2ogvA:
29.9		 3oezB-2ogvA:
34.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2p4i ANGIOPOIETIN-1
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 838
ALA A 853
VAL A 875
TYR A 904
LEU A 971
ALA A 981
ASP A 982
 MR9  A 301 (-4.6A)
MR9  A 301 (-3.5A)
MR9  A 301 ( 4.8A)
MR9  A 301 (-3.8A)
MR9  A 301 (-4.5A)
MR9  A 301 (-3.2A)
MR9  A 301 (-4.2A)
 0.83A 3oezB-2p4iA:
24.0		 3oezB-2p4iA:
33.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 751
THR A 753
TYR A 755
 None
 0.83A 3oezB-2r2pA:
32.5		 3oezB-2r2pA:
43.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 689
ALA A 705
MET A 728
ILE A 751
THR A 753
TYR A 755
LEU A 807
 None
 0.67A 3oezB-2r2pA:
32.5		 3oezB-2r2pA:
43.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4f MYOSIN LIGHT CHAIN
KINASE FAMILY MEMBER
4

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 120
ALA A 133
LYS A 135
GLU A 151
VAL A 154
MET A 155
TYR A 182
 16X  A1374 (-4.8A)
16X  A1374 ( 3.8A)
16X  A1374 ( 4.3A)
None
None
None
16X  A1374 (-4.1A)
 0.69A 3oezB-2x4fA:
23.5		 3oezB-2x4fA:
24.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL A  34
ALA A  47
LYS A  49
GLU A  66
VAL A  69
ILE A  93
TYR A  97
LEU A 147
ALA A 157
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
None
None
J60  A1294 (-4.5A)
J60  A1294 (-4.8A)
J60  A1294 ( 4.2A)
 0.92A 3oezB-2xikA:
19.7		 3oezB-2xikA:
30.29
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		9 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 697
THR A 699
TYR A 701
LEU A 753
ASP A 764
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.6A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-4.3A)
None
 0.88A 3oezB-2xyuA:
28.0		 3oezB-2xyuA:
43.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2zv7 TYROSINE-PROTEIN
KINASE LYN

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 261
ALA A 273
MET A 294
ILE A 317
THR A 319
LEU A 374
ALA A 384
 None
 0.78A 3oezB-2zv7A:
27.4		 3oezB-2zv7A:
64.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 495
ALA A 515
LYS A 517
MET A 538
TYR A 566
LEU A 633
ALA A 643
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
M33  A1996 ( 4.7A)
M33  A1996 (-4.5A)
None
 0.68A 3oezB-3b2tA:
24.4		 3oezB-3b2tA:
37.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A1092
ALA A1108
GLU A1127
MET A1131
TYR A1159
ALA A1221
ASP A1222
 CKK  A1500 ( 4.3A)
CKK  A1500 (-3.2A)
CKK  A1500 (-3.4A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
CKK  A1500 (-3.4A)
CKK  A1500 (-4.5A)
 0.84A 3oezB-3c1xA:
26.8		 3oezB-3c1xA:
32.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 3.7A)
None
C4F  A   1 (-4.6A)
C4F  A   1 (-3.6A)
 0.80A 3oezB-3c4fA:
29.9		 3oezB-3c4fA:
36.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
GLU A 236
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.58A 3oezB-3d7uA:
26.8		 3oezB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 209
ALA A 220
LYS A 222
VAL A 239
MET A 240
ILE A 264
THR A 266
TYR A 268
LEU A 321
 None
 0.60A 3oezB-3d7uA:
26.8		 3oezB-3d7uA:
41.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dko EPHRIN TYPE-A
RECEPTOR 7

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
LEU A 765
ASP A 776
 IHZ  A1001 ( 4.4A)
IHZ  A1001 (-3.3A)
IHZ  A1001 ( 4.5A)
IHZ  A1001 (-3.5A)
None
IHZ  A1001 (-4.6A)
IHZ  A1001 (-4.8A)
 0.80A 3oezB-3dkoA:
33.1		 3oezB-3dkoA:
41.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iec SERINE/THREONINE-PRO
TEIN KINASE MARK2

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		9 VAL A  67
ALA A  80
LYS A  82
GLU A 100
MET A 104
TYR A 131
LEU A 182
ALA A 192
ASP A 193
 None
 1.04A 3oezB-3iecA:
22.8		 3oezB-3iecA:
27.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
GLU A 684
MET A 688
ILE A 711
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.54A 3oezB-3kulA:
33.0		 3oezB-3kulA:
38.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		8 VAL A 649
ALA A 665
LYS A 667
GLU A 684
ILE A 711
THR A 713
TYR A 715
LEU A 767
 None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
 0.74A 3oezB-3kulA:
33.0		 3oezB-3kulA:
38.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm5 SERINE/THREONINE-PRO
TEIN KINASE 17B

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  47
ALA A  60
LYS A  62
GLU A  80
VAL A  83
TYR A 112
LEU A 165
 QUE  A   1 ( 4.6A)
QUE  A   1 (-3.2A)
QUE  A   1 (-4.1A)
QUE  A   1 (-3.1A)
None
QUE  A   1 (-4.9A)
None
 0.80A 3oezB-3lm5A:
24.4		 3oezB-3lm5A:
27.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
LEU A 339
ALA A 349
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-4.5A)
LDN  A   1 ( 3.8A)
 0.82A 3oezB-3mdyA:
24.4		 3oezB-3mdyA:
28.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LYS A 229
GLU A 242
THR A 277
TYR A 279
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
None
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
 0.79A 3oezB-3my0A:
24.8		 3oezB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
LEU A 337
ALA A 347
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-4.6A)
LDN  A 600 ( 3.8A)
 0.64A 3oezB-3my0A:
24.8		 3oezB-3my0A:
27.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  96
ALA A 109
GLU A 130
VAL A 133
MET A 134
TYR A 161
LEU A 212
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.87A 3oezB-3nuuA:
23.1		 3oezB-3nuuA:
25.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz6 MITOGEN-ACTIVATED
PROTEIN KINASE 1,
SERINE/THREONINE
PROTEIN KINASE

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		7 VAL A  25
ALA A  38
LYS A  40
GLU A  58
TYR A  92
LEU A 141
ALA A 151
 None
 0.87A 3oezB-3oz6A:
20.3		 3oezB-3oz6A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfq PROTEIN KINASE C
BETA TYPE

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00130
(C1_1)
PF00168
(C2)
PF00433
(Pkinase_C) 		7 VAL A 356
ALA A 369
LYS A 371
GLU A 390
VAL A 393
TYR A 422
ALA A 483
 ANP  A 800 ( 4.7A)
ANP  A 800 (-3.6A)
ANP  A 800 (-3.3A)
None
None
ANP  A 800 (-4.2A)
ANP  A 800 ( 3.8A)
 0.87A 3oezB-3pfqA:
15.2		 3oezB-3pfqA:
17.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		9 VAL A 565
ALA A 576
LYS A 578
GLU A 596
MET A 600
ILE A 623
THR A 625
TYR A 627
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-4.3A)
 0.56A 3oezB-3ppzA:
29.5		 3oezB-3ppzA:
32.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
LEU A 207
ALA A 217
 NM7  A 416 (-3.7A)
NM7  A 416 ( 3.7A)
EDO  A 417 (-3.5A)
EDO  A 417 (-4.0A)
NM7  A 416 (-4.4A)
NM7  A 416 ( 4.2A)
NM7  A 416 ( 4.5A)
 0.76A 3oezB-3qfvA:
19.2		 3oezB-3qfvA:
23.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s95 LIM DOMAIN KINASE 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 LYS A 368
VAL A 387
MET A 388
THR A 413
TYR A 415
LEU A 467
ALA A 477
 STU  A   1 (-3.1A)
None
None
STU  A   1 (-3.9A)
STU  A   1 (-4.7A)
STU  A   1 (-4.6A)
STU  A   1 ( 4.1A)
 0.89A 3oezB-3s95A:
24.9		 3oezB-3s95A:
34.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 443
LYS A 445
MET A 464
ILE A 487
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-3.2A)
PP2  A   1 (-4.5A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.71A 3oezB-3sxsA:
31.8		 3oezB-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 431
ALA A 443
MET A 464
ILE A 487
THR A 489
TYR A 491
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.6A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 (-4.6A)
 0.45A 3oezB-3sxsA:
31.8		 3oezB-3sxsA:
42.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 ( 4.4A)
07J  A   1 (-3.2A)
 0.78A 3oezB-3tt0A:
30.1		 3oezB-3tt0A:
33.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
LEU A 208
ALA A 218
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
EDO  A1420 ( 4.8A)
None
 0.74A 3oezB-4aw2A:
20.1		 3oezB-4aw2A:
25.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc6 SERINE/THREONINE-PRO
TEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  50
ALA A  63
LYS A  65
GLU A  81
ILE A 108
LEU A 164
ALA A 174
 XZN  A1317 ( 4.7A)
XZN  A1317 (-3.5A)
XZN  A1317 (-4.1A)
XZN  A1317 (-3.9A)
XZN  A1317 (-4.4A)
XZN  A1317 (-4.7A)
XZN  A1317 ( 4.3A)
 0.79A 3oezB-4bc6A:
21.7		 3oezB-4bc6A:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c02 ACTIVIN RECEPTOR
TYPE-1

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 222
ALA A 233
LYS A 235
THR A 283
TYR A 285
LEU A 343
ALA A 353
 TAK  A1507 (-4.7A)
TAK  A1507 (-3.3A)
TAK  A1507 ( 4.5A)
TAK  A1507 (-3.6A)
TAK  A1507 ( 4.6A)
TAK  A1507 (-4.7A)
TAK  A1507 ( 4.2A)
 0.62A 3oezB-4c02A:
24.8		 3oezB-4c02A:
28.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
LEU A 146
ALA A 156
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-4.3A)
STU  A1550 ( 3.8A)
 0.79A 3oezB-4cfhA:
17.1		 3oezB-4cfhA:
23.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 624
ALA A 653
GLU A 672
MET A 676
THR A 701
TYR A 703
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 0.95A 3oezB-4ckrA:
30.5		 3oezB-4ckrA:
35.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 624
ALA A 653
LYS A 655
MET A 676
THR A 701
TYR A 703
LEU A 773
ALA A 783
ASP A 784
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.7A)
DI1  A1000 (-4.1A)
 1.00A 3oezB-4ckrA:
30.5		 3oezB-4ckrA:
35.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
LEU A 789
ALA A 799
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
AGS  A1985 (-4.8A)
AGS  A1985 ( 4.5A)
 0.68A 3oezB-4crsA:
16.4		 3oezB-4crsA:
24.79
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 385
ALA A 400
LYS A 402
GLU A 420
VAL A 423
MET A 424
LEU A 501
 0SB  A 701 (-4.0A)
0SB  A 701 (-3.3A)
0SB  A 701 ( 4.8A)
None
None
None
0SB  A 701 (-4.4A)
 0.70A 3oezB-4f4pA:
30.3		 3oezB-4f4pA:
36.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f99 CELL DIVISION CYCLE
7-RELATED PROTEIN
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  72
ALA A  88
LYS A  90
GLU A 104
ILE A 132
TYR A 136
LEU A 184
 ADP  A 601 (-4.0A)
ADP  A 601 (-3.5A)
ADP  A 601 (-2.6A)
None
None
ADP  A 601 (-4.1A)
ADP  A 601 ( 4.9A)
 0.72A 3oezB-4f99A:
14.9		 3oezB-4f99A:
26.20
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k11 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
ILE A 336
TYR A 340
LEU A 393
ALA A 403
 0J9  A 601 (-4.4A)
0J9  A 601 (-3.3A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.4A)
0J9  A 601 ( 4.7A)
0J9  A 601 (-4.5A)
0J9  A 601 (-3.5A)
 0.62A 3oezB-4k11A:
34.1		 3oezB-4k11A:
94.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
TYR A 557
LEU A 624
ALA A 634
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
ACP  A 801 (-4.4A)
None
 0.71A 3oezB-4k33A:
25.3		 3oezB-4k33A:
36.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
LYS A  56
GLU A  70
MET A  74
TYR A 101
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
 0.89A 3oezB-4lg4A:
18.2		 3oezB-4lg4A:
28.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg4 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  41
ALA A  54
LYS A  56
MET A  74
ILE A  97
TYR A 101
ALA A 163
 GOL  A 404 (-4.5A)
GOL  A 404 ( 3.1A)
GOL  A 403 ( 4.6A)
None
None
GOL  A 404 ( 4.9A)
GOL  A 403 ( 3.0A)
 0.84A 3oezB-4lg4A:
18.2		 3oezB-4lg4A:
28.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
GLU A 310
VAL A 313
MET A 314
ILE A 336
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
VGG  A 601 ( 4.3A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
 0.84A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
LYS A 295
VAL A 313
MET A 314
ILE A 336
TYR A 340
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
VGG  A 601 (-3.8A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 ( 4.2A)
 0.79A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lgg PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Gallus gallus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 281
ALA A 293
VAL A 313
MET A 314
ILE A 336
TYR A 340
LEU A 393
ALA A 403
 VGG  A 601 ( 3.5A)
VGG  A 601 (-3.5A)
None
VGG  A 601 ( 3.6A)
VGG  A 601 (-4.2A)
VGG  A 601 ( 4.0A)
VGG  A 601 (-4.5A)
VGG  A 601 ( 4.2A)
 0.75A 3oezB-4lggA:
37.1		 3oezB-4lggA:
99.26
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		8 ALA B  51
GLU B  70
VAL B  73
ILE B  97
TYR B 101
LEU B 151
ALA B 161
ASP B 162
 ADP  B 500 (-3.3A)
None
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
ADP  B 500 ( 3.4A)
 1.01A 3oezB-4o27B:
19.0		 3oezB-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		9 VAL B  38
ALA B  51
LYS B  53
GLU B  70
VAL B  73
ILE B  97
TYR B 101
LEU B 151
ALA B 161
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
None
None
ADP  B 500 ( 4.7A)
ADP  B 500 (-4.7A)
None
 0.75A 3oezB-4o27B:
19.0		 3oezB-4o27B:
30.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
GLU A 663
MET A 667
ILE A 690
THR A 692
TYR A 694
 None
 0.87A 3oezB-4p2kA:
32.4		 3oezB-4p2kA:
43.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 394
ALA A 407
GLU A 428
VAL A 431
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.83A 3oezB-4q9zA:
15.6		 3oezB-4q9zA:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9z HUMAN PROTEIN KINASE
C THETA

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 394
ALA A 407
LYS A 409
VAL A 431
TYR A 460
LEU A 511
ALA A 521
 PZW  A 801 (-4.6A)
PZW  A 801 (-3.5A)
None
None
None
PZW  A 801 (-4.8A)
PZW  A 801 ( 4.6A)
 0.88A 3oezB-4q9zA:
15.6		 3oezB-4q9zA:
24.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 624
ALA A 642
LYS A 644
GLU A 661
MET A 665
TYR A 693
LEU A 818
ASP A 829
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 ( 3.7A)
P30  A1001 (-4.1A)
P30  A1001 (-4.6A)
None
 1.19A 3oezB-4rt7A:
25.3		 3oezB-4rt7A:
32.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
LYS A  37
ILE A  79
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.82A 3oezB-4ueuA:
34.0		 3oezB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
LYS A  37
MET A  56
THR A  81
TYR A  83
LEU A 136
ALA A 146
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
ACP  A1264 ( 4.8A)
None
None
 0.99A 3oezB-4ueuA:
34.0		 3oezB-4ueuA:
62.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 481
ALA A 501
LYS A 503
GLU A 520
VAL A 523
MET A 524
LEU A 619
ALA A 629
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
None
40M  A1002 (-3.8A)
40M  A1002 (-4.5A)
40M  A1002 (-3.0A)
 0.78A 3oezB-4xcuA:
24.8		 3oezB-4xcuA:
39.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 9 VAL B 275
ALA B 288
LYS B 290
VAL B 308
MET B 309
ILE B 332
THR B 334
LEU B 389
ALA B 399
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-4.6A)
None
1N1  B 601 (-3.7A)
1N1  B 601 (-4.1A)
1N1  B 601 (-3.3A)
1N1  B 601 (-4.3A)
1N1  B 601 (-3.5A)
 0.53A 3oezB-4xeyB:
25.1		 3oezB-4xeyB:
36.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
LEU A 818
ASP A 829
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-4.3A)
None
 0.77A 3oezB-4xufA:
24.7		 3oezB-4xufA:
37.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
GLU A 509
ILE A 537
THR A 539
TYR A 541
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
None
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.74A 3oezB-4yffA:
20.3		 3oezB-4yffA:
27.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 477
ALA A 488
LYS A 490
ILE A 537
THR A 539
TYR A 541
LEU A 595
ALA A 605
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 (-4.4A)
4CV  A 801 ( 3.9A)
 0.70A 3oezB-4yffA:
20.3		 3oezB-4yffA:
27.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
LEU A 630
ALA A 640
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 (-4.2A)
38O  A1769 (-4.6A)
EDO  A1766 ( 4.4A)
 0.84A 3oezB-5a46A:
30.6		 3oezB-5a46A:
33.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
ILE A 672
THR A 674
TYR A 676
LEU A 825
ASP A 836
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.9A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 (-4.3A)
748  A1001 (-4.8A)
 0.91A 3oezB-5grnA:
25.8		 3oezB-5grnA:
34.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
ILE A 128
TYR A 132
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
None
IDV  A 401 (-3.5A)
IDV  A 401 (-4.4A)
 0.74A 3oezB-5i3oA:
21.9		 3oezB-5i3oA:
24.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
ILE A  88
LEU A 143
ALA A 153
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
None
6G2  A 901 (-4.7A)
6G2  A 901 ( 4.2A)
 0.72A 3oezB-5j5tA:
21.8		 3oezB-5j5tA:
24.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 726
ALA A 743
LYS A 745
GLU A 762
VAL A 765
MET A 766
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
None
6HJ  A1101 ( 4.1A)
6HJ  A1101 ( 4.8A)
 0.85A 3oezB-5j9zA:
31.4		 3oezB-5j9zA:
33.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A 284
ALA A 297
LYS A 299
GLU A 315
VAL A 318
MET A 319
TYR A 346
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-4.5A)
IPW  A 601 (-3.9A)
None
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 (-4.5A)
 0.65A 3oezB-5kbrA:
22.8		 3oezB-5kbrA:
27.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 709
THR A 711
LEU A 765
ASP A 776
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
6P6  A1001 ( 4.5A)
6P6  A1001 (-3.5A)
6P6  A1001 (-4.5A)
None
 0.75A 3oezB-5l6oA:
32.2		 3oezB-5l6oA:
41.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7q RHO-ASSOCIATED
PROTEIN KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 106
ALA A 119
LYS A 121
GLU A 140
TYR A 171
LEU A 221
ALA A 231
 None
 0.91A 3oezB-5u7qA:
19.6		 3oezB-5u7qA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 VAL A  32
ALA A  45
ILE A  93
THR A  95
TYR A  97
LEU A 153
ALA A 163
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.9A)
9WS  A 401 (-3.2A)
None
9WS  A 401 (-4.6A)
9WS  A 401 ( 4.0A)
 0.68A 3oezB-5w5jA:
23.7		 3oezB-5w5jA:
28.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 VAL A 899
ALA A 917
LYS A 919
ILE A 961
THR A 963
TYR A 965
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
None
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 (-4.7A)
 0.59A 3oezB-5wnoA:
28.4		 3oezB-5wnoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao5 SERINE/THREONINE-PRO
TEIN KINASE 3

(Homo sapiens) 		no annotation 7 VAL A  41
ALA A  54
LYS A  56
ILE A  97
TYR A 101
LEU A 153
ALA A 163
 ANP  A 501 (-4.4A)
ANP  A 501 ( 3.7A)
ANP  A 501 (-2.4A)
None
ANP  A 501 ( 4.2A)
ANP  A 501 (-4.6A)
None
 0.64A 3oezB-6ao5A:
22.9		 3oezB-6ao5A:
24.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 VAL A 741
ALA A 754
LYS A 756
GLU A 774
TYR A 815
LEU A 866
ALA A 876
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
CJM  A1102 (-4.4A)
CJM  A1102 (-3.6A)
 0.75A 3oezB-6b3eA:
23.2		 3oezB-6b3eA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9d SERINE/THREONINE-PRO
TEIN KINASE
MARK1,SERINE/THREONI
NE-PROTEIN KINASE
MARK1

(Homo sapiens) 		no annotation 8 VAL A  74
ALA A  87
LYS A  89
GLU A 107
MET A 111
TYR A 138
LEU A 189
ALA A 199
 None
 0.84A 3oezB-6c9dA:
22.0		 3oezB-6c9dA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyo DUAL SPECIFICITY
PROTEIN KINASE CLK1

(Homo sapiens) 		no annotation 7 VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 209
ILE A 239
LEU A 295
 None
EAQ  A 501 (-3.6A)
EAQ  A 501 (-3.2A)
EAQ  A 501 (-3.4A)
None
None
EAQ  A 501 (-4.9A)
 0.91A 3oezB-6fyoA:
22.0		 3oezB-6fyoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyv DUAL SPECIFICITY
PROTEIN KINASE CLK4

(Homo sapiens) 		no annotation 7 VAL A 175
ALA A 189
LYS A 191
GLU A 206
VAL A 209
ILE A 239
LEU A 295
 3NG  A 501 ( 4.3A)
3NG  A 501 (-3.5A)
3NG  A 501 (-2.7A)
3NG  A 501 ( 4.7A)
None
None
None
 0.78A 3oezB-6fyvA:
22.1		 3oezB-6fyvA:
undetectable