SIMILAR PATTERNS OF AMINO ACIDS FOR 3O9M_B_BEZB999

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ap8 TRANSLATION
INITIATION FACTOR
EIF4E

(Saccharomyces
cerevisiae) 		PF01652
(IF4E) 		4 GLY A 112
GLY A 113
TRP A 115
LEU A 165
 None
 0.70A 3o9mB-1ap8A:
undetectable		 3o9mB-1ap8A:
17.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1aql BILE-SALT ACTIVATED
LIPASE

(Bos taurus) 		PF00135
(COesterase) 		4 GLY A 107
SER A 194
TRP A 227
HIS A 435
 None
 0.82A 3o9mB-1aqlA:
52.2		 3o9mB-1aqlA:
32.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ava BARLEY
ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Hordeum vulgare) 		PF00197
(Kunitz_legume) 		4 GLY C  31
GLY C  30
SER C  24
HIS C 171
 None
 0.78A 3o9mB-1avaC:
undetectable		 3o9mB-1avaC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ava BARLEY
ALPHA-AMYLASE/SUBTIL
ISIN INHIBITOR

(Hordeum vulgare) 		PF00197
(Kunitz_legume) 		4 GLY C  32
GLY C  31
SER C  24
HIS C 171
 None
 0.76A 3o9mB-1avaC:
undetectable		 3o9mB-1avaC:
14.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azw PROLINE
IMINOPEPTIDASE

(Xanthomonas
citri) 		PF00561
(Abhydrolase_1) 		4 GLY A  42
GLY A  43
SER A 110
HIS A 294
 None
 0.83A 3o9mB-1azwA:
12.8		 3o9mB-1azwA:
19.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A 121
GLY A 122
SER A 203
TRP A 236
HIS A 447
 None
 0.37A 3o9mB-1b41A:
57.3		 3o9mB-1b41A:
52.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1c2o ACETYLCHOLINESTERASE

(Electrophorus
electricus) 		PF00135
(COesterase) 		5 GLY A 121
GLY A 122
SER A 203
TRP A 236
HIS A 447
 None
 0.39A 3o9mB-1c2oA:
57.0		 3o9mB-1c2oA:
52.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cle CHOLESTEROL ESTERASE

([Candida]
cylindracea) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 302
HIS A 449
 CLL  A 801 (-3.3A)
CLL  A 801 (-3.3A)
CLL  A 801 ( 2.8A)
CLL  A 801 (-4.0A)
CLL  A 801 (-4.8A)
 0.60A 3o9mB-1cleA:
43.7		 3o9mB-1cleA:
28.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpy SERINE
CARBOXYPEPTIDASE

(Saccharomyces
cerevisiae) 		PF00450
(Peptidase_S10) 		4 GLY A  52
GLY A  53
SER A 146
HIS A 397
 None
 0.82A 3o9mB-1cpyA:
12.1		 3o9mB-1cpyA:
22.02
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1crl LIPASE

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 302
HIS A 449
 None
 0.78A 3o9mB-1crlA:
40.4		 3o9mB-1crlA:
30.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		4 GLY A  83
GLY A  84
SER A 155
HIS A 282
 EPE  A 455 (-3.3A)
EPE  A 455 (-3.3A)
EPE  A 455 (-1.4A)
EPE  A 455 (-4.0A)
 0.40A 3o9mB-1evqA:
3.5		 3o9mB-1evqA:
22.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gqr ACETYLCHOLINESTERASE

(Tetronarce
californica) 		PF00135
(COesterase) 		5 GLY A 118
GLY A 119
SER A 200
TRP A 233
HIS A 440
 SAF  A1998 ( 3.5A)
EMM  A1999 (-3.5A)
EMM  A1999 ( 1.4A)
EMM  A1999 (-4.0A)
EMM  A1999 ( 3.8A)
 0.62A 3o9mB-1gqrA:
61.5		 3o9mB-1gqrA:
53.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 GLY A 123
GLY A 124
SER A 209
LEU A 302
HIS A 449
 None
 0.72A 3o9mB-1gz7A:
42.3		 3o9mB-1gz7A:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jji CARBOXYLESTERASE

(Archaeoglobus
fulgidus) 		PF07859
(Abhydrolase_3) 		4 GLY A  88
GLY A  89
SER A 160
HIS A 285
 EPE  A 455 (-3.7A)
EPE  A 455 (-3.4A)
EPE  A 455 (-1.6A)
EPE  A 455 (-4.6A)
 0.64A 3o9mB-1jjiA:
5.6		 3o9mB-1jjiA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		4 GLY A 127
GLY A 128
SER A 202
HIS A 338
 None
 0.42A 3o9mB-1jkmA:
8.1		 3o9mB-1jkmA:
19.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1jmy BILE-SALT-ACTIVATED
LIPASE

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A 107
SER A 194
TRP A 227
HIS A 435
 None
 0.45A 3o9mB-1jmyA:
52.7		 3o9mB-1jmyA:
34.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1qon ACETYLCHOLINESTERASE

(Drosophila
melanogaster) 		PF00135
(COesterase) 		6 GLY A 150
GLY A 151
SER A 238
TRP A 271
LEU A 328
HIS A 480
 I40  A 997 (-3.9A)
SO4  A 593 (-3.4A)
SO4  A 593 (-1.9A)
SO4  A 593 (-4.4A)
None
SO4  A 593 (-4.1A)
 0.51A 3o9mB-1qonA:
59.7		 3o9mB-1qonA:
37.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rxm DNA POLYMERASE
SLIDING CLAMP

(Archaeoglobus
fulgidus) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		4 GLY A 187
GLY A 186
SER A 156
LEU A 181
 None
 0.78A 3o9mB-1rxmA:
undetectable		 3o9mB-1rxmA:
16.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ukc ESTA

(Aspergillus
niger) 		PF00135
(COesterase) 		4 GLY A 127
GLY A 128
SER A 210
HIS A 440
 EDO  A1902 (-3.6A)
EDO  A1902 (-3.4A)
EDO  A1902 (-2.4A)
EDO  A1902 ( 4.9A)
 0.51A 3o9mB-1ukcA:
38.7		 3o9mB-1ukcA:
29.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zl0 HYPOTHETICAL PROTEIN
PA5198

(Pseudomonas
aeruginosa) 		PF02016
(Peptidase_S66) 		4 GLY A  87
GLY A  88
SER A 115
HIS A 285
 EDO  A1407 (-3.5A)
EDO  A1408 ( 3.4A)
TLA  A1401 ( 2.0A)
EDO  A1407 ( 3.9A)
 0.75A 3o9mB-1zl0A:
undetectable		 3o9mB-1zl0A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2asu HEPATOCYTE GROWTH
FACTOR-LIKE PROTEIN

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLY B 663
GLY B 662
SER B 510
LEU B 569
 None
 0.75A 3o9mB-2asuB:
undetectable		 3o9mB-2asuB:
16.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 GLY A  82
GLY A  83
SER A 154
LEU A 210
HIS A 281
 None
 1.30A 3o9mB-2c7bA:
19.3		 3o9mB-2c7bA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fg1 CONSERVED
HYPOTHETICAL PROTEIN
BT1257

(Bacteroides
thetaiotaomicron) 		PF01661
(Macro) 		4 GLY A  17
SER A 117
LEU A  74
HIS A 119
 None
 0.80A 3o9mB-2fg1A:
2.6		 3o9mB-2fg1A:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 GLY A 145
GLY A 146
SER A 226
LEU A 313
HIS A 471
 TFC  A 600 (-3.5A)
TFC  A 600 (-3.4A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
TFC  A 600 (-4.2A)
 1.09A 3o9mB-2fj0A:
49.8		 3o9mB-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		4 GLY A 146
GLY A 147
SER A 226
HIS A 471
 TFC  A 600 (-3.4A)
TFC  A 600 (-3.6A)
TFC  A 600 (-1.4A)
TFC  A 600 (-4.2A)
 0.80A 3o9mB-2fj0A:
49.8		 3o9mB-2fj0A:
28.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hiq HYPOTHETICAL PROTEIN
YDHR

(Escherichia
coli) 		PF08803
(ydhR) 		4 GLY A  58
GLY A  59
LEU A  12
HIS A  76
 None
 0.77A 3o9mB-2hiqA:
2.1		 3o9mB-2hiqA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 GLY A 135
GLY A 136
LEU A 138
HIS A 375
 None
 0.83A 3o9mB-2hruA:
undetectable		 3o9mB-2hruA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hrz NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Agrobacterium
fabrum) 		PF01370
(Epimerase) 		4 GLY A  35
GLY A  36
SER A  33
LEU A   4
 None
 0.80A 3o9mB-2hrzA:
undetectable		 3o9mB-2hrzA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iu3 BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Gallus gallus) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 GLY A 128
GLY A 129
LEU A   9
HIS A  74
 None
 0.75A 3o9mB-2iu3A:
undetectable		 3o9mB-2iu3A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 GLY A  80
GLY A  81
SER A  46
LEU A  62
 None
 0.80A 3o9mB-2nttA:
undetectable		 3o9mB-2nttA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7r CXE CARBOXYLESTERASE

(Actinidia
eriantha) 		PF07859
(Abhydrolase_3) 		5 GLY A  92
GLY A  93
SER A 169
LEU A 227
HIS A 306
 4PA  A 369 (-3.5A)
4PA  A 369 (-3.6A)
4PA  A 369 (-1.8A)
None
4PA  A 369 (-4.8A)
 0.53A 3o9mB-2o7rA:
19.4		 3o9mB-2o7rA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl5 HOMOSERINE
O-ACETYLTRANSFERASE

(Leptospira
interrogans) 		PF00561
(Abhydrolase_1) 		4 GLY A 155
GLY A 152
TRP A  75
LEU A 348
 None
 0.78A 3o9mB-2pl5A:
14.8		 3o9mB-2pl5A:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qru UNCHARACTERIZED
PROTEIN

(Enterococcus
faecalis) 		PF07859
(Abhydrolase_3) 		4 GLY A  34
GLY A  35
SER A 102
HIS A 247
 PO4  A 273 (-3.3A)
PO4  A 273 (-3.5A)
PO4  A 273 (-2.3A)
PO4  A 273 (-4.0A)
 0.47A 3o9mB-2qruA:
14.5		 3o9mB-2qruA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uz0 TRIBUTYRIN ESTERASE

(Streptococcus
pneumoniae) 		PF00756
(Esterase) 		4 GLY A  44
SER A 120
LEU A 158
HIS A 231
 GOL  A1259 (-3.2A)
GOL  A1259 (-2.9A)
None
GOL  A1259 (-3.9A)
 0.76A 3o9mB-2uz0A:
15.5		 3o9mB-2uz0A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6g PROGESTERONE
5-BETA-REDUCTASE

(Digitalis
lanata) 		PF01370
(Epimerase) 		5 GLY A  53
GLY A  54
SER A  27
LEU A  46
HIS A 100
 None
 1.19A 3o9mB-2v6gA:
2.2		 3o9mB-2v6gA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yh2 ESTERASE

(Pyrobaculum
calidifontis) 		PF07859
(Abhydrolase_3) 		4 GLY A  85
GLY A  86
SER A 157
HIS A 284
 None
 0.46A 3o9mB-2yh2A:
19.4		 3o9mB-2yh2A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ail 303AA LONG
HYPOTHETICAL
ESTERASE

(Sulfurisphaera
tokodaii) 		PF07859
(Abhydrolase_3) 		4 GLY A  79
GLY A  80
SER A 150
HIS A 273
 DEP  A 304 (-3.6A)
DEP  A 304 (-3.5A)
DEP  A 304 (-1.5A)
DEP  A 304 (-4.1A)
 0.34A 3o9mB-3ailA:
19.0		 3o9mB-3ailA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ce9 GLYCEROL
DEHYDROGENASE

(Clostridium
acetobutylicum) 		PF13685
(Fe-ADH_2) 		4 GLY A  96
GLY A  97
SER A 120
LEU A 265
 EDO  A 401 ( 3.8A)
None
EDO  A 401 (-3.4A)
None
 0.70A 3o9mB-3ce9A:
undetectable		 3o9mB-3ce9A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dja PROTEIN CT_858

(Chlamydia
trachomatis) 		PF03572
(Peptidase_S41) 		4 GLY A 375
GLY A 376
SER A 499
HIS A 105
 None
 0.79A 3o9mB-3djaA:
2.1		 3o9mB-3djaA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g23 LD-CARBOXYPEPTIDASE
A

(Novosphingobium
aromaticivorans) 		PF02016
(Peptidase_S66) 		4 GLY A  76
GLY A  77
SER A 104
HIS A 261
 None
SO4  A 276 ( 4.6A)
None
None
 0.59A 3o9mB-3g23A:
3.0		 3o9mB-3g23A:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ga7 ACETYL ESTERASE

(Salmonella
enterica) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLY A  94
LEU A 221
HIS A 292
 SEP  A 165 ( 3.6A)
SEP  A 165 ( 3.5A)
None
SEP  A 165 ( 3.9A)
 0.55A 3o9mB-3ga7A:
18.4		 3o9mB-3ga7A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdn R-OXYNITRILE LYASE
ISOENZYME 1

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 105
GLY A 104
SER A 107
LEU A 200
 FAD  A 522 (-3.1A)
None
None
None
 0.77A 3o9mB-3gdnA:
undetectable		 3o9mB-3gdnA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h04 UNCHARACTERIZED
PROTEIN

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		4 GLY A  38
GLY A  39
SER A 104
HIS A 248
 None
 0.35A 3o9mB-3h04A:
16.2		 3o9mB-3h04A:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 GLY A  51
GLY A  52
SER A 127
TRP A 161
HIS A 231
 None
 1.24A 3o9mB-3hxkA:
16.7		 3o9mB-3hxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		5 GLY A  52
GLY A  53
SER A 127
TRP A 161
HIS A 231
 None
 1.07A 3o9mB-3hxkA:
16.7		 3o9mB-3hxkA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ils AFLATOXIN
BIOSYNTHESIS
POLYKETIDE SYNTHASE

(Aspergillus
parasiticus) 		PF00975
(Thioesterase) 		4 GLY A1874
SER A1937
LEU A1974
HIS A2088
 None
 0.78A 3o9mB-3ilsA:
10.1		 3o9mB-3ilsA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3js8 CHOLESTEROL OXIDASE

(Chromobacterium
sp. DS-1) 		PF01565
(FAD_binding_4)
PF09129
(Chol_subst-bind) 		4 GLY A 137
GLY A 136
LEU A 171
HIS A 201
 FAD  A 541 (-3.4A)
FAD  A 541 (-3.8A)
None
FAD  A 541 (-4.2A)
 0.77A 3o9mB-3js8A:
undetectable		 3o9mB-3js8A:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6k ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  89
GLY A  90
SER A 157
HIS A 281
 None
 0.35A 3o9mB-3k6kA:
16.9		 3o9mB-3k6kA:
19.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		5 GLY A1141
GLY A1142
SER A1221
LEU A1363
HIS A1468
 WW2  A 193 (-3.8A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
WW2  A 193 (-3.8A)
None
 1.17A 3o9mB-3k9bA:
53.3		 3o9mB-3k9bA:
36.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k9b LIVER
CARBOXYLESTERASE 1

(Homo sapiens) 		PF00135
(COesterase) 		4 GLY A1142
GLY A1143
SER A1221
HIS A1468
 WW2  A 193 (-3.4A)
WW2  A 193 (-3.4A)
WW2  A 193 (-1.4A)
None
 0.42A 3o9mB-3k9bA:
53.3		 3o9mB-3k9bA:
36.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvn ESTERASE ESTA

(Pseudomonas
aeruginosa) 		no annotation 4 GLY X  92
SER X  14
LEU X 150
HIS X 289
 C8E  X 623 ( 4.4A)
C8E  X 623 (-2.9A)
None
C8E  X 623 (-4.4A)
 0.79A 3o9mB-3kvnX:
undetectable		 3o9mB-3kvnX:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3red HYDROXYNITRILE LYASE

(Prunus mume) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 GLY A 105
GLY A 104
SER A 107
LEU A 200
 FAD  A 773 (-3.3A)
None
None
None
 0.81A 3o9mB-3redA:
undetectable		 3o9mB-3redA:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr3 MICROCIN IMMUNITY
PROTEIN MCCF

(Bacillus
anthracis) 		PF02016
(Peptidase_S66) 		4 GLY A  85
GLY A  86
SER A 112
HIS A 303
 None
 0.75A 3o9mB-3sr3A:
3.4		 3o9mB-3sr3A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlz MCCF

(Escherichia
coli) 		PF02016
(Peptidase_S66) 		4 GLY A  91
GLY A  92
SER A 118
HIS A 311
 AMP  A 500 (-3.2A)
AMP  A 500 (-3.9A)
AMP  A 500 (-2.5A)
AMP  A 500 (-3.7A)
 0.69A 3o9mB-3tlzA:
undetectable		 3o9mB-3tlzA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9a ESTERASE/LIPASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  76
GLY A  77
SER A 144
HIS A 268
 None
 0.49A 3o9mB-3v9aA:
16.8		 3o9mB-3v9aA:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		4 GLY A  85
GLY A  86
SER A 156
HIS A 281
 None
 0.47A 3o9mB-3wj2A:
7.5		 3o9mB-3wj2A:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wmt PROBABLE FERULOYL
ESTERASE B-1

(Aspergillus
oryzae) 		PF07519
(Tannase) 		4 GLY A 124
GLY A 125
SER A 203
HIS A 457
 None
 0.75A 3o9mB-3wmtA:
12.4		 3o9mB-3wmtA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4az3 LYSOSOMAL PROTECTIVE
PROTEIN 32 KDA CHAIN
LYSOSOMAL PROTECTIVE
PROTEIN 20 KDA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00450
(Peptidase_S10)
PF00450
(Peptidase_S10) 		4 GLY A  56
GLY A  57
SER A 150
HIS B 429
 S35  A1259 ( 3.7A)
S35  A1259 ( 3.6A)
S35  A1259 ( 3.8A)
S35  A1259 ( 3.9A)
 0.82A 3o9mB-4az3A:
9.8		 3o9mB-4az3A:
19.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4be9 STEROL ESTERASE

(Ophiostoma
piceae) 		PF00135
(COesterase) 		4 GLY A 134
GLY A 135
SER A 220
HIS A 465
 PGE  A1554 ( 4.7A)
1PE  A1553 (-3.3A)
1PE  A1553 (-2.9A)
None
 0.47A 3o9mB-4be9A:
42.6		 3o9mB-4be9A:
31.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		4 GLY B  63
GLY B  64
SER B 130
HIS B 274
 None
 0.77A 3o9mB-4ccyB:
13.2		 3o9mB-4ccyB:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eys MCCC FAMILY PROTEIN

(Streptococcus
pneumoniae) 		PF02016
(Peptidase_S66) 		4 GLY A  79
GLY A  80
SER A 109
HIS A 315
 AMP  A 401 (-3.0A)
AMP  A 401 (-4.7A)
AMP  A 401 (-2.9A)
AMP  A 401 (-3.9A)
 0.71A 3o9mB-4eysA:
2.0		 3o9mB-4eysA:
20.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4fnm E3 ALPHA-ESTERASE-7
CARBOXYLESTERASE

(Lucilia cuprina) 		PF00135
(COesterase) 		5 GLY A 136
GLY A 137
SER A 218
TRP A 251
HIS A 471
 DPF  A 601 (-3.4A)
DPF  A 601 (-3.7A)
DPF  A 601 (-1.5A)
DPF  A 601 ( 3.7A)
DPF  A 601 (-4.2A)
 0.43A 3o9mB-4fnmA:
38.9		 3o9mB-4fnmA:
32.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j0k TANNASE

(Lactobacillus
plantarum) 		no annotation 4 GLY A  76
GLY A  77
SER A 163
HIS A 451
 EGR  A 501 (-3.3A)
EGR  A 501 (-3.3A)
EGR  A 501 (-2.6A)
EGR  A 501 (-3.8A)
 0.76A 3o9mB-4j0kA:
19.2		 3o9mB-4j0kA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn7 ENOLASE

(Agrobacterium
tumefaciens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 GLY A 271
GLY A 270
SER A 273
LEU A  70
 None
 0.71A 3o9mB-4jn7A:
undetectable		 3o9mB-4jn7A:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kry ACETYL ESTERASE

(Escherichia
coli) 		PF07859
(Abhydrolase_3) 		4 GLY A  93
GLY A  94
LEU A 221
HIS A 292
 SEB  A 165 ( 3.6A)
SEB  A 165 ( 3.5A)
PGE  A 401 (-4.1A)
SEB  A 165 ( 4.1A)
 0.49A 3o9mB-4kryA:
4.4		 3o9mB-4kryA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5i ESTERASE/LIPASE

(Lactobacillus
rhamnosus) 		PF07859
(Abhydrolase_3) 		4 GLY X  75
GLY X  76
SER X 146
HIS X 278
 2HD  X 401 (-3.5A)
2HD  X 401 (-3.6A)
2HD  X 401 (-1.7A)
2HD  X 401 (-3.5A)
 0.57A 3o9mB-4n5iX:
20.6		 3o9mB-4n5iX:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		4 GLY A  80
GLY A  81
SER A 151
HIS A 274
 None
 0.43A 3o9mB-4p9nA:
18.6		 3o9mB-4p9nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3k MGS-M1

(unidentified) 		PF00326
(Peptidase_S9)
PF07859
(Abhydrolase_3) 		4 GLY A  42
GLY A  43
SER A 113
HIS A 201
 F  A 302 (-3.9A)
F  A 302 (-3.4A)
F  A 302 (-2.5A)
None
 0.49A 3o9mB-4q3kA:
18.7		 3o9mB-4q3kA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q3o MGS-MT1

(unidentified) 		PF07859
(Abhydrolase_3) 		5 GLY A 126
GLY A 127
SER A 194
LEU A 251
HIS A 320
 CL  A 401 ( 4.4A)
CL  A 401 (-3.5A)
CL  A 401 (-2.5A)
None
None
 1.39A 3o9mB-4q3oA:
16.4		 3o9mB-4q3oA:
20.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qww ACETYLCHOLINESTERASE

(Bungarus
fasciatus) 		PF00135
(COesterase) 		5 GLY A 118
GLY A 119
SER A 200
TRP A 233
HIS A 440
 None
 0.33A 3o9mB-4qwwA:
61.4		 3o9mB-4qwwA:
50.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rw0 LIPOLYTIC PROTEIN
G-D-S-L FAMILY

(Veillonella
parvula) 		PF13472
(Lipase_GDSL_2) 		4 GLY A  42
SER A   9
LEU A  77
HIS A 162
 None
 0.82A 3o9mB-4rw0A:
2.7		 3o9mB-4rw0A:
16.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 161
LEU A 218
HIS A 292
 None
 0.76A 3o9mB-4wy5A:
8.3		 3o9mB-4wy5A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  89
GLY A  90
SER A 164
LEU A 217
HIS A 291
 None
 1.25A 3o9mB-4wy8A:
8.5		 3o9mB-4wy8A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy8 ESTERASE

(Rhizomucor
miehei) 		PF07859
(Abhydrolase_3) 		5 GLY A  90
GLY A  91
SER A 164
LEU A 217
HIS A 291
 None
 1.41A 3o9mB-4wy8A:
8.5		 3o9mB-4wy8A:
20.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		6 GLY A 116
GLY A 117
SER A 198
TRP A 231
LEU A 286
HIS A 438
 40V  A1001 (-3.2A)
40V  A1001 (-3.4A)
40V  A1001 (-3.1A)
40V  A1001 (-3.4A)
40V  A1001 ( 4.7A)
40V  A1001 (-3.6A)
 0.50A 3o9mB-4xiiA:
70.4		 3o9mB-4xiiA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ypv EST8

(Parvibaculum) 		PF07859
(Abhydrolase_3) 		4 GLY A  87
GLY A  88
SER A 159
HIS A 283
 None
 0.33A 3o9mB-4ypvA:
8.6		 3o9mB-4ypvA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aoc ESTERASE

(Thermogutta
terrifontis) 		PF07859
(Abhydrolase_3) 		4 GLY A  53
GLY A  54
SER A 126
HIS A 248
 LEA  A1283 (-3.4A)
LEA  A1283 (-3.5A)
LEA  A1283 (-2.3A)
LEA  A1283 (-4.0A)
 0.50A 3o9mB-5aocA:
4.8		 3o9mB-5aocA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5fv4 CARBOXYLIC ESTER
HYDROLASE

(Sus scrofa) 		PF00135
(COesterase) 		4 GLY A 125
GLY A 126
SER A 204
HIS A 449
 None
 0.38A 3o9mB-5fv4A:
52.8		 3o9mB-5fv4A:
33.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gms ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  77
GLY A  78
SER A 145
HIS A 269
 None
 0.66A 3o9mB-5gmsA:
16.8		 3o9mB-5gmsA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 GLY A 107
GLY A 108
SER A 188
LEU A  24
HIS A 317
 TRS  A 402 ( 3.8A)
TRS  A 402 (-3.3A)
TRS  A 402 (-2.3A)
None
TRS  A 402 (-4.3A)
 1.33A 3o9mB-5hc4A:
20.9		 3o9mB-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 108
GLY A 109
SER A 188
HIS A 317
 TRS  A 402 (-3.3A)
TRS  A 402 (-3.4A)
TRS  A 402 (-2.3A)
TRS  A 402 (-4.3A)
 0.50A 3o9mB-5hc4A:
20.9		 3o9mB-5hc4A:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A 126
GLY A 127
SER A 201
HIS A 333
 None
 0.43A 3o9mB-5iq0A:
21.3		 3o9mB-5iq0A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd5 MGS-MILE3

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 GLY A  98
GLY A  99
LEU A 225
HIS A 295
 OAS  A 169 ( 4.0A)
OAS  A 169 ( 3.0A)
None
OAS  A 169 ( 4.1A)
 0.55A 3o9mB-5jd5A:
7.8		 3o9mB-5jd5A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k50 L-THREONINE
3-DEHYDROGENASE

(Trypanosoma
brucei) 		no annotation 4 GLY A1012
GLY A1015
LEU A1020
HIS A1043
 NAD  A1401 (-3.4A)
None
None
None
 0.83A 3o9mB-5k50A:
4.0		 3o9mB-5k50A:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l26 NUCLEOSIDE PERMEASE

(Neisseria
wadsworthii) 		PF01773
(Nucleos_tra2_N)
PF07662
(Nucleos_tra2_C)
PF07670
(Gate) 		4 GLY A 179
GLY A 180
SER A 145
LEU A 379
 None
NA  A 506 ( 4.9A)
None
None
 0.78A 3o9mB-5l26A:
undetectable		 3o9mB-5l26A:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 GLY A 379
GLY A 380
SER A 458
HIS A 572
 None
 0.82A 3o9mB-5l8sA:
16.7		 3o9mB-5l8sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		4 GLY A 118
GLY A 119
SER A 190
HIS A 317
 None
 0.46A 3o9mB-5mifA:
19.6		 3o9mB-5mifA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n6m APOLIPOPROTEIN
N-ACYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00795
(CN_hydrolase) 		4 GLY A 166
GLY A 167
SER A 171
LEU A 428
 GOL  A 603 ( 3.7A)
None
None
None
 0.77A 3o9mB-5n6mA:
undetectable		 3o9mB-5n6mA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nit GLUCOSE OXIDASE

(Aspergillus
niger) 		no annotation 4 GLY A 384
GLY A 385
LEU A 326
HIS A 437
 None
 0.81A 3o9mB-5nitA:
undetectable		 3o9mB-5nitA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sga PROTEINASE A (SGPA)

(Streptomyces
griseus) 		PF00089
(Trypsin) 		4 GLY E  18
GLY E  19
SER E 198
LEU E 157
 None
 0.80A 3o9mB-5sgaE:
undetectable		 3o9mB-5sgaE:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 GLY A 127
GLY A 126
SER A  87
TRP A 165
 None
 0.81A 3o9mB-5t1aA:
undetectable		 3o9mB-5t1aA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thm ESTERASE-6

(Drosophila
melanogaster) 		PF00135
(COesterase) 		4 GLY A 109
SER A 188
TRP A 221
HIS A 445
 7BZ  A 601 (-3.0A)
7BZ  A 601 (-1.4A)
None
7BZ  A 601 (-3.8A)
 0.36A 3o9mB-5thmA:
40.4		 3o9mB-5thmA:
28.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5w1u CARBOXYLIC ESTER
HYDROLASE

(Culex
quinquefasciatus) 		PF00135
(COesterase) 		5 GLY A 109
GLY A 110
SER A 191
TRP A 224
HIS A 442
 EPE  A 600 (-3.0A)
EPE  A 600 ( 4.4A)
MLI  A 601 ( 3.8A)
MLI  A 601 (-3.4A)
EPE  A 600 ( 4.0A)
 0.44A 3o9mB-5w1uA:
41.1		 3o9mB-5w1uA:
31.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		4 GLY A 159
GLY A 156
TRP A  80
LEU A 354
 None
 0.79A 3o9mB-5w8oA:
13.1		 3o9mB-5w8oA:
22.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8p HOMOSERINE
O-ACETYLTRANSFERASE

(Mycobacteroides
abscessus) 		PF00561
(Abhydrolase_1) 		4 GLY A 162
GLY A 159
TRP A  83
LEU A 361
 None
 0.74A 3o9mB-5w8pA:
12.8		 3o9mB-5w8pA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ydj ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLY A 279
GLY A 280
TRP A 393
HIS A 600
 SEB  A 360 ( 3.0A)
SEB  A 360 ( 3.0A)
None
SEB  A 360 ( 4.2A)
 0.49A 3o9mB-5ydjA:
65.9		 3o9mB-5ydjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yhp COLD ACTIVE PROLINE
IMINOPEPTIDASE

(Glaciozyma
antarctica) 		no annotation 4 GLY A  42
GLY A  43
SER A 111
HIS A 297
 FLC  A 402 ( 3.8A)
FLC  A 402 (-3.4A)
FLC  A 402 (-2.5A)
FLC  A 402 (-3.7A)
 0.81A 3o9mB-5yhpA:
12.8		 3o9mB-5yhpA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6arx ACETYLCHOLINESTERASE

(Anopheles
gambiae) 		no annotation 4 GLY A 279
SER A 360
TRP A 393
HIS A 600
 None
 0.37A 3o9mB-6arxA:
64.3		 3o9mB-6arxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fd2 PUTATIVE APRAMYCIN
BIOSYNTHETIC
OXIDOREDUCTASE 4

(Streptoalloteichus
tenebrarius) 		no annotation 4 GLY B  28
GLY B  29
SER B 219
LEU B  86
 None
 0.83A 3o9mB-6fd2B:
3.3		 3o9mB-6fd2B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g21 PROBABLE FERULOYL
ESTERASE B-2

(Aspergillus
oryzae) 		no annotation 4 GLY A  90
GLY A  91
SER A 169
HIS A 421
 None
 0.77A 3o9mB-6g21A:
12.2		 3o9mB-6g21A:
undetectable