SIMILAR PATTERNS OF AMINO ACIDS FOR 3O94_D_NCAD192_0
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ff9 | SACCHAROPINEREDUCTASE (Magnaporthegrisea) |
PF03435(Sacchrp_dh_NADP)PF16653(Sacchrp_dh_C) | 5 | PHE A 254LEU A 258PHE A 263LEU A 322ILE A 324 | None | 1.33A | 3o94D-1ff9A:5.4 | 3o94D-1ff9A:19.55 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 5 | ASP A 10PHE A 15ASP A 52GLU A 101TYR A 103 | NoneNone ZN A 400 (-2.5A) ZN A 400 ( 4.1A)None | 1.10A | 3o94D-1im5A:25.9 | 3o94D-1im5A:30.37 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1im5 | 180AA LONGHYPOTHETICALPYRAZINAMIDASE/NICOTINAMIDASE (Pyrococcushorikoshii) |
PF00857(Isochorismatase) | 6 | ASP A 10PHE A 15LEU A 21ASP A 52HIS A 71TYR A 103 | NoneNoneNone ZN A 400 (-2.5A) ZN A 400 (-3.4A)None | 0.64A | 3o94D-1im5A:25.9 | 3o94D-1im5A:30.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jr9 | MANGANESE SUPEROXIDEDISMUTASE (Virgibacillushalodenitrificans) |
PF00081(Sod_Fe_N)PF02777(Sod_Fe_C) | 5 | PHE A 3LEU A 39HIS A 79LEU A 57ILE A 58 | None | 1.49A | 3o94D-1jr9A:undetectable | 3o94D-1jr9A:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1l5a | AMIDE SYNTHASE (Vibrio cholerae) |
PF00668(Condensation) | 5 | PHE A 364GLU A 250HIS A 393LEU A 256SER A 331 | None | 1.28A | 3o94D-1l5aA:undetectable | 3o94D-1l5aA:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1qi7 | PROTEIN(N-GLYCOSIDASE) (Saponariaofficinalis) |
PF00161(RIP) | 5 | LEU A 114GLU A 118PHE A 90ILE A 123SER A 122 | None | 1.30A | 3o94D-1qi7A:undetectable | 3o94D-1qi7A:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1r2f | PROTEIN(RIBONUCLEOTIDEREDUCTASE R2) (Salmonellaenterica) |
PF00268(Ribonuc_red_sm) | 5 | ASP A 67GLU A 192HIS A 101LEU A 184ILE A 185 | FE A 400 (-3.0A) FE A 400 ( 2.1A) FE A 400 (-3.4A)NoneNone | 1.36A | 3o94D-1r2fA:undetectable | 3o94D-1r2fA:23.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1skx | ORPHAN NUCLEARRECEPTOR PXR (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ASP A 266LEU A 365PHE A 369ILE A 261SER A 262 | None | 1.47A | 3o94D-1skxA:undetectable | 3o94D-1skxA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sus | CAFFEOYL-COAO-METHYLTRANSFERASE (Medicago sativa) |
PF01596(Methyltransf_3) | 5 | PHE A 161LEU A 71ASP A 189PHE A 70ILE A 242 | NoneNone CA A 305 (-3.2A)NoneNone | 1.25A | 3o94D-1susA:2.6 | 3o94D-1susA:21.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u7g | PROBABLE AMMONIUMTRANSPORTER (Escherichiacoli) |
PF00909(Ammonium_transp) | 5 | PHE A 193LEU A 35ASP A 313PHE A 31LEU A 259 | NoneNoneBOG A 400 (-4.7A)NH3 A 401 ( 4.3A)BOG A 400 (-4.3A) | 1.46A | 3o94D-1u7gA:undetectable | 3o94D-1u7gA:19.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1wyt | GLYCINEDEHYDROGENASE(DECARBOXYLATING)SUBUNIT 1 (Thermusthermophilus) |
PF02347(GDC-P) | 5 | LEU A 258PHE A 269TYR A 113LEU A 120ILE A 117 | None | 1.39A | 3o94D-1wytA:undetectable | 3o94D-1wytA:19.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1yqe | HYPOTHETICAL UPF0204PROTEIN AF0625 (Archaeoglobusfulgidus) |
PF04414(tRNA_deacylase) | 5 | ASP A 18GLU A 46TYR A 37LEU A 20ILE A 44 | None | 1.43A | 3o94D-1yqeA:undetectable | 3o94D-1yqeA:21.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z54 | PROBABLETHIOESTERASE (Thermusthermophilus) |
PF03061(4HBT) | 5 | PHE A 89LEU A 87PHE A 54HIS A 107TYR A 44 | NoneNoneNoneGOL A 502 ( 4.9A)GOL A 502 (-4.8A) | 1.38A | 3o94D-1z54A:undetectable | 3o94D-1z54A:22.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zjc | AMINOPEPTIDASE AMPS (Staphylococcusaureus) |
PF02073(Peptidase_M29) | 5 | ASP A 383GLU A 319PHE A 255HIS A 348TYR A 355 | CO A 502 ( 2.2A) CO A 501 ( 2.6A) CO A 501 ( 4.9A) CO A 501 (-3.4A) CO A 502 (-4.9A) | 1.49A | 3o94D-1zjcA:undetectable | 3o94D-1zjcA:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2cjk | NUCLEARPOLYADENYLATEDRNA-BINDING PROTEIN4 (Saccharomycescerevisiae) |
PF00076(RRM_1) | 5 | ASP A 224LEU A 175PHE A 179LEU A 166ILE A 228 | None | 1.14A | 3o94D-2cjkA:undetectable | 3o94D-2cjkA:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dh8 | DAZ-ASSOCIATEDPROTEIN 1 (Homo sapiens) |
PF00076(RRM_1) | 5 | ASP A 76LEU A 26PHE A 30LEU A 17ILE A 80 | None | 1.21A | 3o94D-2dh8A:undetectable | 3o94D-2dh8A:21.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fw2 | TESTIS-SPECIFICCHROMODOMAIN PROTEINY 2 (Homo sapiens) |
PF00378(ECH_1) | 5 | ASP A 145PHE A 92LEU A 121ILE A 118SER A 117 | None | 1.04A | 3o94D-2fw2A:undetectable | 3o94D-2fw2A:22.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0r | NICOTINAMIDASE (Saccharomycescerevisiae) |
PF00857(Isochorismatase) | 5 | ASP A 8ASP A 51GLU A 129HIS A 53TYR A 131 | None ZN A 301 (-2.6A) ZN A 301 ( 3.9A) ZN A 301 (-3.2A)None | 1.46A | 3o94D-2h0rA:23.2 | 3o94D-2h0rA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0r | NICOTINAMIDASE (Saccharomycescerevisiae) |
PF00857(Isochorismatase) | 5 | ASP A 8PHE A 13ASP A 51GLU A 129TYR A 131 | NoneNone ZN A 301 (-2.6A) ZN A 301 ( 3.9A)None | 1.04A | 3o94D-2h0rA:23.2 | 3o94D-2h0rA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2h0r | NICOTINAMIDASE (Saccharomycescerevisiae) |
PF00857(Isochorismatase) | 6 | ASP A 8PHE A 13LEU A 20ASP A 51HIS A 94TYR A 131 | NoneNoneNone ZN A 301 (-2.6A) ZN A 301 (-3.4A)None | 0.50A | 3o94D-2h0rA:23.2 | 3o94D-2h0rA:24.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2k9u | GAMMA FILAMIN (Homo sapiens) |
PF00630(Filamin) | 5 | ASP A 98PHE A 101LEU A 28PHE A 39ILE A 89 | None | 1.32A | 3o94D-2k9uA:undetectable | 3o94D-2k9uA:23.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pft | EXOCYTOSIS PROTEIN (Mus musculus) |
PF03081(Exo70) | 5 | LEU A 188GLU A 296HIS A 190LEU A 170SER A 230 | None | 1.28A | 3o94D-2pftA:undetectable | 3o94D-2pftA:17.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlw | RHAU (Rhizobiumleguminosarum) |
PF05336(rhaM) | 5 | PHE A 55PHE A 8TYR A 43ILE A 45SER A 44 | None | 1.41A | 3o94D-2qlwA:undetectable | 3o94D-2qlwA:25.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2qlx | L-RHAMNOSEMUTAROTASE (Rhizobiumleguminosarum) |
PF05336(rhaM) | 5 | PHE A 55PHE A 8TYR A 43ILE A 45SER A 44 | NoneNoneRM4 A 300 (-4.6A)NoneNone | 1.41A | 3o94D-2qlxA:undetectable | 3o94D-2qlxA:21.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2r26 | CITRATE SYNTHASE (Thermoplasmaacidophilum) |
PF00285(Citrate_synt) | 5 | PHE A 160LEU A 161PHE A 165TYR A 139LEU A 339 | None | 1.44A | 3o94D-2r26A:undetectable | 3o94D-2r26A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rh7 | GREEN FLUORESCENTPROTEIN (Renillareniformis) |
PF01353(GFP) | 5 | PHE A 87LEU A 113TYR A 72LEU A 8ILE A 37 | None | 1.32A | 3o94D-2rh7A:undetectable | 3o94D-2rh7A:23.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rhp | THROMBOSPONDIN-2 (Homo sapiens) |
PF02412(TSP_3)PF05735(TSP_C)PF07645(EGF_CA)PF12947(EGF_3) | 5 | ASP A 939ASP A 937HIS A 887ILE A 954SER A 955 | CA A1173 ( 2.9A) CA A 2 ( 2.6A)NoneNone CA A1173 (-2.9A) | 1.01A | 3o94D-2rhpA:undetectable | 3o94D-2rhpA:15.88 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2wt9 | NICOTINAMIDASE (Acinetobacterbaumannii) |
PF00857(Isochorismatase) | 6 | ASP A 16PHE A 21LEU A 27ASP A 54HIS A 89TYR A 123 | NIO A1216 (-3.8A)NIO A1216 (-3.7A)None ZN A1212 ( 2.6A) ZN A1212 ( 3.5A)NIO A1216 (-4.9A) | 0.42A | 3o94D-2wt9A:22.3 | 3o94D-2wt9A:31.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xp1 | SPT6 (Antonosporalocustae) |
PF14633(SH2_2) | 5 | ASP A 944ASP A 946PHE A 905HIS A 879LEU A 935 | None | 1.29A | 3o94D-2xp1A:undetectable | 3o94D-2xp1A:21.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d37 | TAIL PROTEIN, 43 KDA (Neisseriameningitidis) |
no annotation | 5 | ASP A 53LEU A 87LEU A 54ILE A 73SER A 55 | None | 1.28A | 3o94D-3d37A:undetectable | 3o94D-3d37A:19.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dx5 | UNCHARACTERIZEDPROTEIN ASBF (Bacillusanthracis) |
PF01261(AP_endonuc_2) | 5 | ASP A 237PHE A 230LEU A 229PHE A 199ILE A 239 | None | 1.40A | 3o94D-3dx5A:undetectable | 3o94D-3dx5A:21.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eef | N-CARBAMOYLSARCOSINEAMIDASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00857(Isochorismatase) | 6 | ASP A 9ASP A 50GLU A 58HIS A 52TYR A 93ILE A 122 | None ZN A 183 (-2.6A) ZN A 183 (-2.6A) ZN A 183 (-3.4A)NoneNone | 1.47A | 3o94D-3eefA:25.1 | 3o94D-3eefA:29.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eef | N-CARBAMOYLSARCOSINEAMIDASE RELATEDPROTEIN (Thermoplasmaacidophilum) |
PF00857(Isochorismatase) | 7 | ASP A 9PHE A 14ASP A 50GLU A 58HIS A 65TYR A 93ILE A 122 | NoneNone ZN A 183 (-2.6A) ZN A 183 (-2.6A) ZN A 183 (-3.4A)NoneNone | 0.61A | 3o94D-3eefA:25.1 | 3o94D-3eefA:29.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ein | GLUTATHIONES-TRANSFERASE 1-1 (Drosophilamelanogaster) |
PF00043(GST_C)PF02798(GST_N) | 5 | ASP A 58LEU A 27PHE A 4LEU A 73ILE A 69 | None | 1.39A | 3o94D-3einA:undetectable | 3o94D-3einA:23.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kws | PUTATIVE SUGARISOMERASE (Parabacteroidesdistasonis) |
PF01261(AP_endonuc_2) | 5 | LEU A 192ASP A 223GLU A 287HIS A 226ILE A 147 | None MG A 401 (-3.1A) MG A 401 (-2.6A)NoneNone | 1.41A | 3o94D-3kwsA:undetectable | 3o94D-3kwsA:20.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ngf | AP ENDONUCLEASE,FAMILY 2 (Brucellaabortus) |
PF01261(AP_endonuc_2) | 5 | ASP A 177GLU A 33HIS A 201LEU A 178ILE A 204 | MN A 262 (-3.2A)NoneNoneNoneNone | 1.49A | 3o94D-3ngfA:undetectable | 3o94D-3ngfA:22.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3o0y | LIPOPROTEIN (Colwelliapsychrerythraea) |
PF05960(DUF885) | 5 | PHE A 116LEU A 42PHE A 43LEU A 460ILE A 463 | None | 1.49A | 3o94D-3o0yA:undetectable | 3o94D-3o0yA:16.47 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3o90 | NICOTINAMIDASE (Streptococcuspneumoniae) |
PF00857(Isochorismatase) | 10 | ASP A 9PHE A 14LEU A 21ASP A 53GLU A 64PHE A 68HIS A 71TYR A 106LEU A 132ILE A 135 | NoneNoneNone ZN A 192 (-2.3A) ZN A 192 (-2.6A)None ZN A 192 (-3.2A)NoneNoneNone | 0.65A | 3o94D-3o90A:37.0 | 3o94D-3o90A:99.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odn | DALLY-LIKE PROTEIN (Drosophilamelanogaster) |
PF01153(Glypican) | 5 | PHE A 195LEU A 194PHE A 216LEU A 366ILE A 370 | None | 1.48A | 3o94D-3odnA:undetectable | 3o94D-3odnA:17.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3odp | PUTATIVETAGATOSE-6-PHOSPHATEKETOSE/ALDOSEISOMERASE (Clostridiumnovyi) |
PF01380(SIS) | 5 | LEU A 49GLU A 83PHE A 191LEU A 110ILE A 60 | None | 0.94A | 3o94D-3odpA:2.2 | 3o94D-3odpA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pl1 | PYRAZINAMIDASE/NICOTINAMIDASE PNCA(PZASE) (Mycobacteriumtuberculosis) |
PF00857(Isochorismatase) | 5 | ASP A 8PHE A 13LEU A 19ASP A 49HIS A 71 | NoneNoneNoneFE2 A 188 (-2.6A)FE2 A 188 (-3.4A) | 0.64A | 3o94D-3pl1A:21.8 | 3o94D-3pl1A:29.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qfv | CDC42BPB PROTEIN (Homo sapiens) |
PF00069(Pkinase) | 5 | ASP A 132PHE A 219LEU A 194ILE A 191SER A 190 | None | 1.24A | 3o94D-3qfvA:undetectable | 3o94D-3qfvA:18.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qs1 | PLASMEPSIN-1 (Plasmodiumfalciparum) |
PF00026(Asp) | 5 | PHE A 29LEU A 38PHE A 101TYR A 56ILE A 20 | None | 1.43A | 3o94D-3qs1A:undetectable | 3o94D-3qs1A:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r2j | ALPHA/BETA-HYDROLASE-LIKE PROTEIN (Leishmaniainfantum) |
PF00857(Isochorismatase) | 6 | ASP A 32PHE A 37LEU A 44ASP A 73HIS A 92TYR A 126 | NIO A 311 (-3.9A)NoneNone ZN A 301 ( 2.5A) ZN A 301 ( 3.4A)None | 0.50A | 3o94D-3r2jA:23.2 | 3o94D-3r2jA:28.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r5x | D-ALANINE--D-ALANINELIGASE (Bacillusanthracis) |
PF01820(Dala_Dala_lig_N)PF07478(Dala_Dala_lig_C) | 5 | ASP A 151LEU A 126PHE A 123LEU A 155ILE A 156 | None | 1.44A | 3o94D-3r5xA:undetectable | 3o94D-3r5xA:24.01 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 5 | ASP A 9ASP A 53GLU A 64HIS A 55TYR A 106 | CAD A 185 (-3.7A) ZN A 184 (-2.6A) ZN A 184 (-2.5A) ZN A 184 (-3.3A)None | 1.31A | 3o94D-3s2sA:35.7 | 3o94D-3s2sA:71.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3s2s | PUTATIVEPYRAZINAMIDASE/NICOTINAMIDASE (Streptococcusmutans) |
PF00857(Isochorismatase) | 10 | ASP A 9PHE A 14LEU A 21ASP A 53GLU A 64PHE A 68HIS A 71TYR A 106LEU A 132ILE A 135 | CAD A 185 (-3.7A)CAD A 185 (-3.3A)None ZN A 184 (-2.6A) ZN A 184 (-2.5A)None ZN A 184 (-3.4A)NoneCAD A 185 (-3.9A)CAD A 185 (-3.4A) | 0.34A | 3o94D-3s2sA:35.7 | 3o94D-3s2sA:71.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3s4w | FANCONI ANEMIA GROUPD2 PROTEIN HOMOLOG (Mus musculus) |
PF14631(FancD2) | 5 | PHE B 451LEU B 415PHE B 419LEU B 455ILE B 433 | None | 1.48A | 3o94D-3s4wB:undetectable | 3o94D-3s4wB:9.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3srz | TOXIN A (Clostridioidesdifficile) |
PF12918(TcdB_N)PF12919(TcdA_TcdB) | 5 | PHE A 435PHE A 430HIS A 431LEU A 446ILE A 449 | None | 1.24A | 3o94D-3srzA:undetectable | 3o94D-3srzA:17.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3szb | ALDEHYDEDEHYDROGENASE (Homo sapiens) |
PF00171(Aldedh) | 5 | PHE A 117LEU A 43TYR A 156LEU A 149ILE A 152 | None | 1.45A | 3o94D-3szbA:2.8 | 3o94D-3szbA:21.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tx1 | UDP-N-ACETYLENOLPYRUVOYLGLUCOSAMINEREDUCTASE (Listeriamonocytogenes) |
PF01565(FAD_binding_4)PF02873(MurB_C) | 5 | ASP A 103LEU A 116PHE A 186LEU A 101ILE A 126 | None | 1.27A | 3o94D-3tx1A:undetectable | 3o94D-3tx1A:22.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zo9 | TREHALOSESYNTHASE/AMYLASETRES (Mycolicibacteriumsmegmatis) |
PF00128(Alpha-amylase)PF16657(Malt_amylase_C) | 5 | LEU A 63PHE A 49TYR A 42LEU A 67ILE A 70 | None | 1.28A | 3o94D-3zo9A:undetectable | 3o94D-3zo9A:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zx2 | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE 1 (Rattusnorvegicus) |
PF01150(GDA1_CD39) | 5 | ASP A 268LEU A 261PHE A 415ILE A 328SER A 327 | None | 1.48A | 3o94D-3zx2A:undetectable | 3o94D-3zx2A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zx2 | ECTONUCLEOSIDETRIPHOSPHATEDIPHOSPHOHYDROLASE 1 (Rattusnorvegicus) |
PF01150(GDA1_CD39) | 5 | LEU A 261ASP A 279PHE A 415ILE A 328SER A 327 | None | 1.43A | 3o94D-3zx2A:undetectable | 3o94D-3zx2A:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj1 | PROTEIN RIF2 (Saccharomycescerevisiae) |
no annotation | 5 | PHE A 232LEU A 236PHE A 247LEU A 266ILE A 110 | None | 1.39A | 3o94D-4bj1A:undetectable | 3o94D-4bj1A:24.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bj6 | RAP1-INTERACTINGFACTOR 2 (Saccharomycescerevisiae) |
no annotation | 5 | PHE A 232LEU A 236PHE A 247LEU A 266ILE A 110 | None | 1.39A | 3o94D-4bj6A:2.1 | 3o94D-4bj6A:23.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4cnm | TROPHOBLASTGLYCOPROTEIN (Homo sapiens) |
PF01462(LRRNT)PF01463(LRRCT)PF13855(LRR_8) | 5 | ASP A 148LEU A 178LEU A 149ILE A 183SER A 150 | CIT A1356 ( 2.5A)NoneNoneNoneCIT A1356 (-3.2A) | 1.25A | 3o94D-4cnmA:undetectable | 3o94D-4cnmA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4eca | L-ASPARAGINEAMIDOHYDROLASE (Escherichiacoli) |
PF00710(Asparaginase) | 5 | ASP A 204LEU A 308PHE A 98LEU A 208SER A 206 | None | 1.28A | 3o94D-4ecaA:undetectable | 3o94D-4ecaA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ecn | LEUCINE-RICH REPEATPROTEIN (Bacteroidesthetaiotaomicron) |
PF14660(DUF4458) | 5 | PHE A 394GLU A 525HIS A 385LEU A 399SER A 381 | None | 1.48A | 3o94D-4ecnA:undetectable | 3o94D-4ecnA:13.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4evq | PUTATIVE ABCTRANSPORTER SUBUNIT,SUBSTRATE-BINDINGCOMPONENT (Rhodopseudomonaspalustris) |
PF13458(Peripla_BP_6) | 5 | ASP A 312PHE A 350LEU A 352LEU A 316ILE A 127 | None | 1.41A | 3o94D-4evqA:undetectable | 3o94D-4evqA:19.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fe2 | PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (Streptococcuspneumoniae) |
PF01259(SAICAR_synt) | 5 | ASP A 209ASP A 211GLU A 108HIS A 207ILE A 173 | None | 1.11A | 3o94D-4fe2A:undetectable | 3o94D-4fe2A:29.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4icq | AMINOPEPTIDASE PEPS (Streptococcuspneumoniae) |
PF02073(Peptidase_M29) | 5 | ASP A 383GLU A 319PHE A 255HIS A 348TYR A 355 | ZN A 501 (-2.2A) ZN A 502 ( 2.5A)None ZN A 502 (-3.5A) ZN A 501 (-4.8A) | 1.47A | 3o94D-4icqA:undetectable | 3o94D-4icqA:20.82 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kav | YHBX/YHJW/YIJP/YJDBFAMILY PROTEIN (Neisseriameningitidis) |
PF00884(Sulfatase) | 5 | LEU A 521ASP A 523PHE A 489LEU A 537ILE A 495 | None | 1.49A | 3o94D-4kavA:undetectable | 3o94D-4kavA:19.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lg1 | PROTEIN-LYSINEMETHYLTRANSFERASEMETTL21D (Homo sapiens) |
PF10294(Methyltransf_16) | 5 | LEU A 53PHE A 58TYR A 219LEU A 141ILE A 170 | None | 1.42A | 3o94D-4lg1A:3.2 | 3o94D-4lg1A:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4myc | IRON-SULFUR CLUSTERSTRANSPORTER ATM1,MITOCHONDRIAL (Saccharomycescerevisiae) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 5 | PHE A 254LEU A 377PHE A 130LEU A 250ILE A 249 | None | 1.36A | 3o94D-4mycA:undetectable | 3o94D-4mycA:16.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ofl | EXTRACYTOPLASMICNICKEL-BINDINGPROTEIN YPYNTA (Yersinia pestis) |
PF00496(SBP_bac_5) | 5 | PHE A 184LEU A 7TYR A 153LEU A 488ILE A 491 | None | 1.40A | 3o94D-4oflA:undetectable | 3o94D-4oflA:17.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ony | EXTRACELLULARSOLUTE-BINDINGPROTEIN FAMILY 5 (Brucellamelitensis) |
PF00496(SBP_bac_5) | 5 | PHE A 540LEU A 531GLU A 498LEU A 361SER A 492 | NoneNoneNoneNone CL A 601 (-4.6A) | 1.36A | 3o94D-4onyA:undetectable | 3o94D-4onyA:17.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pws | PROLINE-RICH 28 KDAANTIGEN (Mycobacteriumtuberculosis) |
PF10738(Lpp-LpqN) | 5 | LEU A 110PHE A 177HIS A 109LEU A 242ILE A 233 | None | 1.27A | 3o94D-4pwsA:undetectable | 3o94D-4pwsA:24.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4q6t | GLYCOSYL HYDROLASE,FAMILY 18 (Pseudomonasprotegens) |
PF00704(Glyco_hydro_18) | 5 | ASP A 102LEU A 146PHE A 162LEU A 67ILE A 118 | None | 1.28A | 3o94D-4q6tA:undetectable | 3o94D-4q6tA:22.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r84 | SIALYLTRANSFERASE0160 (Photobacteriumdamselae) |
PF11477(PM0188) | 5 | ASP A 69PHE A 75LEU A 42PHE A 77ILE A 64 | None | 1.43A | 3o94D-4r84A:5.8 | 3o94D-4r84A:21.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z61 | PHYTOSULFOKINERECEPTOR 1SOMATICEMBRYOGENESISRECEPTOR KINASE 2 (Daucus carota;Arabidopsisthaliana) |
PF00560(LRR_1)PF13855(LRR_8)PF00560(LRR_1)PF08263(LRRNT_2) | 5 | LEU C 79GLU A 584PHE A 606LEU C 50SER C 52 | None | 1.38A | 3o94D-4z61C:undetectable | 3o94D-4z61C:21.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z7e | LMO1422 PROTEIN (Listeriamonocytogenes) |
PF04069(OpuAC) | 5 | ASP A 416LEU A 414PHE A 392TYR A 381ILE A 384 | None | 1.12A | 3o94D-4z7eA:undetectable | 3o94D-4z7eA:23.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zr5 | NEPRILYSIN (Oryctolaguscuniculus) |
PF01431(Peptidase_M13)PF05649(Peptidase_M13_N) | 5 | LEU A 314GLU A 185PHE A 321LEU A 200ILE A 188 | None | 1.46A | 3o94D-4zr5A:undetectable | 3o94D-4zr5A:15.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zxi | TYROCIDINESYNTHETASE 3 (Acinetobacterbaumannii) |
PF00501(AMP-binding)PF00550(PP-binding)PF00668(Condensation)PF00975(Thioesterase)PF13193(AMP-binding_C) | 6 | PHE A 616LEU A 481HIS A 639TYR A 556LEU A 547ILE A 546 | None | 1.44A | 3o94D-4zxiA:2.7 | 3o94D-4zxiA:11.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5auo | ATPASE INVOLVED INCHROMOSOMEPARTITIONING,PARA/MIND FAMILY,MRP HOMOLOG (Thermococcuskodakarensis) |
PF10609(ParA) | 5 | ASP B 139PHE B 147LEU B 114ILE B 115SER B 111 | None | 1.39A | 3o94D-5auoB:3.6 | 3o94D-5auoB:20.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d7a | TRAF2 ANDNCK-INTERACTINGPROTEIN KINASE (Homo sapiens) |
PF00069(Pkinase) | 5 | ASP A 14GLU A 63LEU A 18ILE A 90SER A 16 | ASP A 14 ( 0.6A)GLU A 63 ( 0.6A)LEU A 18 ( 0.6A)ILE A 90 ( 0.7A)SER A 16 ( 0.0A) | 1.21A | 3o94D-5d7aA:undetectable | 3o94D-5d7aA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ek5 | IRMA (Escherichiacoli) |
no annotation | 5 | ASP A 33PHE A 41LEU A 32ILE A 11SER A 12 | None | 1.49A | 3o94D-5ek5A:undetectable | 3o94D-5ek5A:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f0g | GLUTATHIONES-TRANSFERASE D2 (Drosophilamelanogaster) |
PF00043(GST_C)PF02798(GST_N) | 5 | ASP A 57LEU A 26PHE A 3LEU A 72ILE A 68 | None | 1.39A | 3o94D-5f0gA:undetectable | 3o94D-5f0gA:23.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g39 | PHOTOSYSTEM IIMANGANESE-STABILIZING POLYPEPTIDE (Thermosynechococcuselongatus) |
PF01716(MSP) | 5 | PHE A 183LEU A 150PHE A 135LEU A 43ILE A 40 | None | 1.29A | 3o94D-5g39A:undetectable | 3o94D-5g39A:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hb4 | NUP192,NUCLEOPORINNUP192 (Chaetomiumthermophilum) |
PF11894(Nup192) | 5 | PHE B 512LEU B 497PHE B 485LEU B 468ILE B 471 | None | 1.38A | 3o94D-5hb4B:undetectable | 3o94D-5hb4B:8.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jod | PROPLASMEPSIN IV (Plasmodiumfalciparum) |
PF00026(Asp) | 5 | PHE A 31LEU A 40PHE A 102TYR A 58ILE A 22 | None | 1.41A | 3o94D-5jodA:undetectable | 3o94D-5jodA:21.87 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o2j | PROBABLE PHOSPHITETRANSPORTSYSTEM-BINDINGPROTEIN PTXB (Pseudomonasstutzeri) |
no annotation | 5 | ASP A 48LEU A 14ASP A 121ILE A 53SER A 50 | None | 1.39A | 3o94D-5o2jA:undetectable | 3o94D-5o2jA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ov6 | PORPHOBILINOGENDEAMINASE (Bacillusmegaterium) |
PF01379(Porphobil_deam)PF03900(Porphobil_deamC) | 5 | ASP A 104LEU A 106PHE A 114ILE A 190SER A 191 | None | 1.28A | 3o94D-5ov6A:undetectable | 3o94D-5ov6A:22.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tpc | BOTULINUM NEUROTOXINTYPE A (Clostridiumbotulinum) |
PF07951(Toxin_R_bind_C)PF07953(Toxin_R_bind_N) | 5 | LEU A 928ASP A 890LEU A1074ILE A 878SER A 877 | None | 1.41A | 3o94D-5tpcA:undetectable | 3o94D-5tpcA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7u | TREHALOSE SYNTHASE (Thermobaculumterrenum) |
no annotation | 5 | LEU A 35PHE A 21TYR A 14LEU A 39ILE A 42 | None | 1.28A | 3o94D-5x7uA:undetectable | 3o94D-5x7uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7u | TREHALOSE SYNTHASE (Thermobaculumterrenum) |
no annotation | 5 | PHE A 86LEU A 35PHE A 21LEU A 39ILE A 42 | None | 1.31A | 3o94D-5x7uA:undetectable | 3o94D-5x7uA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xwq | FUNGAL CHITINASEFROM RHIZOMUCORMIEHEI (NATIVEPROTEIN) (Rhizomucormiehei) |
no annotation | 5 | PHE A 116LEU A 113ASP A 118GLU A 171LEU A 137 | NoneNone MG A 501 (-2.6A) MG A 501 (-4.2A)None | 1.39A | 3o94D-5xwqA:undetectable | 3o94D-5xwqA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a8l | - (-) |
no annotation | 5 | ASP A 9ASP A 53GLU A 64HIS A 55TYR A 106 | None ZN A 200 (-2.7A) ZN A 200 (-2.4A) ZN A 200 (-3.2A)None | 1.36A | 3o94D-6a8lA:33.9 | 3o94D-6a8lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6a8l | - (-) |
no annotation | 9 | ASP A 9PHE A 14LEU A 21ASP A 53GLU A 64PHE A 68HIS A 71TYR A 106ILE A 135 | NoneNoneNone ZN A 200 (-2.7A) ZN A 200 (-2.4A)None ZN A 200 (-3.4A)NoneNone | 0.72A | 3o94D-6a8lA:33.9 | 3o94D-6a8lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bvp | 3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE (Cupriavidusmetallidurans) |
no annotation | 5 | PHE A 121ASP A 119GLU A 110HIS A 51ILE A 142 | NoneNoneFE2 A 202 ( 4.6A)FE2 A 202 (-3.3A)None | 1.07A | 3o94D-6bvpA:undetectable | 3o94D-6bvpA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6c0d | AMIDASE,HYDANTOINASE/CARBAMOYLASE FAMILY (Paraburkholderiaphymatum) |
no annotation | 5 | LEU A 163ASP A 60LEU A 134ILE A 144SER A 138 | None | 1.30A | 3o94D-6c0dA:undetectable | 3o94D-6c0dA:undetectable |