SIMILAR PATTERNS OF AMINO ACIDS FOR 3O7W_A_SAMA801_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 LYS A 478
ARG A 419
ASP A 405
 None
 1.30A 3o7wA-1cbgA:
0.9		 3o7wA-1cbgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 LYS A  51
ARG A  48
ASP A 352
 None
 1.41A 3o7wA-1csjA:
undetectable		 3o7wA-1csjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 LYS A 518
ARG A 518
ASP A 348
 None
 1.17A 3o7wA-1ewrA:
undetectable		 3o7wA-1ewrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		3 LYS A 271
ARG A 126
ASP A 188
 None
 1.32A 3o7wA-1fpsA:
undetectable		 3o7wA-1fpsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LYS A 240
ARG A 201
ASP A 360
 None
 1.24A 3o7wA-1iqrA:
1.2		 3o7wA-1iqrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		3 LYS A 142
ARG A  43
ASP A  65
 SO4  A 176 (-2.5A)
SO4  A 176 (-2.8A)
None
 1.41A 3o7wA-1jfdA:
undetectable		 3o7wA-1jfdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 LYS A 607
ARG A 624
ASP A 585
 None
 1.08A 3o7wA-1m9iA:
undetectable		 3o7wA-1m9iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		3 LYS A  61
ARG A  66
ASP A 181
 NLG  A1260 ( 4.4A)
NLG  A1260 (-3.9A)
ADP  A1259 ( 4.9A)
 1.30A 3o7wA-1oh9A:
2.5		 3o7wA-1oh9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		3 LYS A 197
ARG A  74
ASP A 179
 None
SO3  A1374 (-2.0A)
None
 1.24A 3o7wA-1okgA:
undetectable		 3o7wA-1okgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3r DISABLED HOMOLOG 2

(Mus musculus) 		PF00640
(PID) 		3 LYS A  90
ARG A  84
ASP A 130
 None
 1.45A 3o7wA-1p3rA:
undetectable		 3o7wA-1p3rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LYS A 762
ARG A 726
ASP A 372
 None
 1.37A 3o7wA-1taqA:
undetectable		 3o7wA-1taqA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 LYS A 108
ARG A 169
ASP A  42
 None
 1.03A 3o7wA-1uazA:
undetectable		 3o7wA-1uazA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		3 LYS A 495
ARG A 129
ASP A 406
 None
 1.39A 3o7wA-1vjvA:
undetectable		 3o7wA-1vjvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsq MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT

(Escherichia
coli) 		PF03830
(PTSIIB_sorb) 		3 LYS C 274
ARG C 271
ASP C 170
 None
 1.25A 3o7wA-1vsqC:
undetectable		 3o7wA-1vsqC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 LYS C 237
ARG C 412
ASP C 159
 None
 1.35A 3o7wA-2d6fC:
undetectable		 3o7wA-2d6fC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 LYS A 446
ARG A 387
ASP A 375
 None
 1.35A 3o7wA-2e3zA:
undetectable		 3o7wA-2e3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf1 INSULIN-LIKE GROWTH
FACTOR I

(Homo sapiens) 		PF00049
(Insulin) 		3 LYS A  68
ARG A  55
ASP A  20
 None
 1.45A 3o7wA-2gf1A:
undetectable		 3o7wA-2gf1A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LYS A 762
ARG A 726
ASP A 372
 None
 1.43A 3o7wA-2ktqA:
undetectable		 3o7wA-2ktqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 140
ARG A  43
ASP A  65
 SO4  A 175 (-2.9A)
SO4  A 175 (-3.1A)
None
 1.43A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 148
ARG A  43
ASP A  67
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.37A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 148
ARG A  43
ASP A  70
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.44A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 LYS A 251
ARG A 248
ASP A  11
 ACY  A 800 (-3.1A)
ACY  A 800 (-3.2A)
None
 1.35A 3o7wA-2q42A:
undetectable		 3o7wA-2q42A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxs INORGANIC
PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00719
(Pyrophosphatase) 		3 LYS A 140
ARG A  37
ASP A  61
 None
PO4  A1167 (-3.7A)
None
 1.33A 3o7wA-2uxsA:
undetectable		 3o7wA-2uxsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw NRFC PROTEIN
HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF13247
(Fer4_11)
PF14589
(NrfD_2) 		3 LYS C   2
ARG B  41
ASP B 103
 None
 1.38A 3o7wA-2vpwC:
undetectable		 3o7wA-2vpwC:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 3 LYS A   0
ARG A  35
ASP A 215
 None
 1.33A 3o7wA-2wjfA:
undetectable		 3o7wA-2wjfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 427
ARG A 454
ASP A 477
 None
 1.20A 3o7wA-2x40A:
undetectable		 3o7wA-2x40A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdp LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF09465
(LBR_tudor) 		3 LYS A 888
ARG A 890
ASP A 914
 None
 1.25A 3o7wA-2xdpA:
undetectable		 3o7wA-2xdpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		3 LYS A 371
ARG A 353
ASP A 339
 None
 1.29A 3o7wA-2xy1A:
undetectable		 3o7wA-2xy1A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LYS A 185
ARG A 890
ASP A 818
 None
 1.42A 3o7wA-2y3aA:
undetectable		 3o7wA-2y3aA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 LYS A  38
ARG A  88
ASP A 144
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
None
 1.25A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 LYS A  38
ARG A  88
ASP A 146
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
 0.31A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 LYS A 280
ARG A 276
ASP A 214
 None
 1.42A 3o7wA-3abzA:
undetectable		 3o7wA-3abzA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A  63
ARG A 314
ASP A 303
 None
 1.41A 3o7wA-3adpA:
4.1		 3o7wA-3adpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		3 LYS X 235
ARG X 237
ASP X 316
 None
 1.35A 3o7wA-3dwoX:
undetectable		 3o7wA-3dwoX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 LYS A 862
ARG A 870
ASP A 173
 GOL  A2003 (-3.5A)
GOL  A2003 (-4.7A)
None
 1.28A 3o7wA-3ecqA:
undetectable		 3o7wA-3ecqA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 LYS A 796
ARG A 792
ASP A 747
 None
None
ADP  A   3 (-3.4A)
 1.46A 3o7wA-3egiA:
9.0		 3o7wA-3egiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 LYS A 914
ARG A1036
ASP A 801
 None
 1.16A 3o7wA-3egwA:
4.2		 3o7wA-3egwA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 182
ARG A 176
ASP A 107
 None
 1.25A 3o7wA-3f81A:
undetectable		 3o7wA-3f81A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 325
ARG A 480
ASP A 417
 None
 1.45A 3o7wA-3fhoA:
3.1		 3o7wA-3fhoA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 125
ARG A 124
ASP A 256
 None
 1.26A 3o7wA-3fxgA:
undetectable		 3o7wA-3fxgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LYS A 157
ARG B 415
ASP A 146
 None
 1.45A 3o7wA-3h32A:
undetectable		 3o7wA-3h32A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 LYS A 223
ARG A 180
ASP A  46
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.3A)
None
 1.37A 3o7wA-3h39A:
undetectable		 3o7wA-3h39A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4q APC40078

(Oleispira
antarctica) 		PF00719
(Pyrophosphatase) 		3 LYS A 143
ARG A  44
ASP A  66
 None
None
NA  A 176 (-2.9A)
 1.36A 3o7wA-3i4qA:
undetectable		 3o7wA-3i4qA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 339
ARG A 357
ASP A 321
 None
 1.27A 3o7wA-3kezA:
undetectable		 3o7wA-3kezA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld3 INORGANIC
PYROPHOSPHATASE

(Anaplasma
phagocytophilum) 		PF00719
(Pyrophosphatase) 		3 LYS A 149
ARG A  44
ASP A  68
 PO4  A 200 ( 4.9A)
PO4  A 200 (-3.2A)
None
 1.44A 3o7wA-3ld3A:
undetectable		 3o7wA-3ld3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 357
ARG A 375
ASP A 327
 None
 1.36A 3o7wA-3mcxA:
undetectable		 3o7wA-3mcxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		3 LYS A 488
ARG A 492
ASP A 466
 None
 1.30A 3o7wA-3mwtA:
undetectable		 3o7wA-3mwtA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 LYS A  37
ARG A  73
ASP A 122
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
 0.01A 3o7wA-3o7wA:
51.6		 3o7wA-3o7wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		3 LYS A 128
ARG A 124
ASP A  13
 None
 1.42A 3o7wA-3sqnA:
undetectable		 3o7wA-3sqnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 LYS A 243
ARG A 245
ASP A 424
 None
 1.34A 3o7wA-3ttfA:
undetectable		 3o7wA-3ttfA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 LYS A  18
ARG A  15
ASP A 364
 None
 1.41A 3o7wA-3ummA:
undetectable		 3o7wA-3ummA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi5 MAJOR OUTER MEMBRANE
PROTEIN P.IB

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		3 LYS A  99
ARG A 125
ASP A 108
 FLC  A 401 (-3.4A)
FLC  A 401 (-3.7A)
None
 1.00A 3o7wA-3wi5A:
undetectable		 3o7wA-3wi5A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		3 LYS A  45
ARG A  48
ASP A  85
 IPE  A 402 (-3.0A)
IPE  A 402 (-2.9A)
None
 1.11A 3o7wA-3wjoA:
undetectable		 3o7wA-3wjoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LYS A 706
ARG A 679
ASP A 489
 None
 0.98A 3o7wA-3zifA:
undetectable		 3o7wA-3zifA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 LYS A 853
ARG A 987
ASP A1151
 None
None
C  R   9 ( 2.8A)
 1.44A 3o7wA-4bocA:
undetectable		 3o7wA-4bocA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LYS A1024
ARG A 853
ASP A 594
 None
 1.42A 3o7wA-4ddwA:
undetectable		 3o7wA-4ddwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF08286
(Spc24) 		3 LYS B 185
ARG B 183
ASP A 215
 None
None
GOL  B 301 (-3.3A)
 1.09A 3o7wA-4geqB:
undetectable		 3o7wA-4geqB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		3 LYS A 421
ARG A 408
ASP A 208
 None
 1.29A 3o7wA-4ifpA:
undetectable		 3o7wA-4ifpA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		3 LYS A 138
ARG A  52
ASP A 147
 None
 1.09A 3o7wA-4lawA:
undetectable		 3o7wA-4lawA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 LYS A 459
ARG A 399
ASP A 387
 None
 1.32A 3o7wA-4mdpA:
undetectable		 3o7wA-4mdpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		3 LYS A  63
ARG A  60
ASP A  88
 None
 1.06A 3o7wA-4mq0A:
undetectable		 3o7wA-4mq0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE

(Sulfurisphaera
tokodaii) 		PF02223
(Thymidylate_kin) 		3 LYS A 147
ARG A 144
ASP A  92
 None
 1.11A 3o7wA-4nzyA:
undetectable		 3o7wA-4nzyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		3 LYS A 291
ARG A 720
ASP A 583
 None
 1.21A 3o7wA-4o5pA:
undetectable		 3o7wA-4o5pA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 3 LYS B 192
ARG B 189
ASP B  94
 None
 1.44A 3o7wA-4p37B:
undetectable		 3o7wA-4p37B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 LYS A 565
ARG A 747
ASP A 590
 None
 1.37A 3o7wA-4r04A:
undetectable		 3o7wA-4r04A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		3 LYS A  35
ARG A  34
ASP A 294
 None
 1.02A 3o7wA-4r3uA:
undetectable		 3o7wA-4r3uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 LYS C 382
ARG C 603
ASP C 305
 None
 1.04A 3o7wA-4u1cC:
undetectable		 3o7wA-4u1cC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 LYS c 382
ARG c 603
ASP c 305
 None
 1.04A 3o7wA-4uerc:
undetectable		 3o7wA-4uerc:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		3 LYS A 805
ARG A 769
ASP A 393
 None
 1.46A 3o7wA-4uqgA:
undetectable		 3o7wA-4uqgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 LYS A 379
ARG A 376
ASP A 187
 None
 1.30A 3o7wA-4utfA:
undetectable		 3o7wA-4utfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		3 LYS A 173
ARG A 169
ASP A 142
 None
 1.17A 3o7wA-4wx6A:
undetectable		 3o7wA-4wx6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		3 LYS D  87
ARG D  83
ASP C  13
 None
 1.27A 3o7wA-4xb6D:
undetectable		 3o7wA-4xb6D:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Pectobacterium
carotovorum) 		PF13561
(adh_short_C2) 		3 LYS A 107
ARG A  97
ASP A  65
 None
 1.44A 3o7wA-4za2A:
5.5		 3o7wA-4za2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		3 LYS 6 336
ARG 6 331
ASP 6 243
 None
 1.01A 3o7wA-5ady6:
undetectable		 3o7wA-5ady6:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263

(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab) 		3 LYS A 411
ARG A 485
ASP B 369
 None
 1.19A 3o7wA-5bn4A:
undetectable		 3o7wA-5bn4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 LYS A 600
ARG A 597
ASP A 115
 None
CA  A 801 ( 4.7A)
None
 1.38A 3o7wA-5bv9A:
undetectable		 3o7wA-5bv9A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LYS B 374
ARG B 356
ASP B 237
 None
 1.39A 3o7wA-5c24B:
undetectable		 3o7wA-5c24B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 291
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.45A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 328
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.35A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 323
 None
 0.94A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 328
 None
None
MG  A 902 (-4.3A)
 1.25A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		3 LYS A 427
ARG A 369
ASP A 409
 None
 1.42A 3o7wA-5dt5A:
undetectable		 3o7wA-5dt5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LYS q  93
ARG q  73
ASP q 205
 None
 1.12A 3o7wA-5gw5q:
undetectable		 3o7wA-5gw5q:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		3 LYS A  91
ARG A 128
ASP A  43
 None
 1.43A 3o7wA-5hdhA:
undetectable		 3o7wA-5hdhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		3 LYS A 190
ARG A 153
ASP A 286
 None
 1.42A 3o7wA-5ifmA:
undetectable		 3o7wA-5ifmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 795
ARG A 210
ASP A 305
 None
 1.23A 3o7wA-5im3A:
undetectable		 3o7wA-5im3A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwl 5F9 DIABODY

(Homo sapiens) 		no annotation 3 LYS B  63
ARG B  38
ASP B 123
 None
 1.41A 3o7wA-5iwlB:
undetectable		 3o7wA-5iwlB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 LYS A 449
ARG A 389
ASP A 377
 None
 1.35A 3o7wA-5jbkA:
undetectable		 3o7wA-5jbkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LYS A 414
ARG A 459
ASP A 512
 None
 1.10A 3o7wA-5jouA:
undetectable		 3o7wA-5jouA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		3 LYS A  43
ARG A 398
ASP A 155
 None
None
CA  A 501 (-3.3A)
 1.38A 3o7wA-5ldtA:
undetectable		 3o7wA-5ldtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1

(Arabidopsis
thaliana) 		PF00719
(Pyrophosphatase) 		3 LYS A 173
ARG A  76
ASP A  98
 None
 1.26A 3o7wA-5ls0A:
undetectable		 3o7wA-5ls0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 398
ARG A 424
ASP A 356
 None
 1.28A 3o7wA-5lx8A:
undetectable		 3o7wA-5lx8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 3 LYS A 347
ARG A 344
ASP A 318
 None
None
MG  A 701 (-2.5A)
 1.22A 3o7wA-5m6gA:
2.1		 3o7wA-5m6gA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 LYS A 427
ARG A 491
ASP A 116
 None
 1.21A 3o7wA-5ngkA:
undetectable		 3o7wA-5ngkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00530
(SRCR) 		3 LYS D 319
ARG D 315
ASP D 289
 None
None
CA  D 401 (-3.3A)
 1.06A 3o7wA-5o32D:
undetectable		 3o7wA-5o32D:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0F02343P
KLLA0E05809P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05859
(Mis12)
PF03980
(Nnf1) 		3 LYS B 114
ARG A 105
ASP A 116
 None
 1.43A 3o7wA-5t58B:
undetectable		 3o7wA-5t58B:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C3257
ARG C2962
ASP C3181
 None
 1.42A 3o7wA-5y3rC:
undetectable		 3o7wA-5y3rC:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7i CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Oreochromis
mossambicus) 		no annotation 3 LYS A 187
ARG A  35
ASP A 111
 None
 1.43A 3o7wA-5y7iA:
undetectable		 3o7wA-5y7iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 3 LYS A 385
ARG A 381
ASP A 128
 None
 1.13A 3o7wA-5z0uA:
undetectable		 3o7wA-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq PFAM DUF35

(Methanothermococcus
thermolithotrophicus) 		no annotation 3 LYS E 124
ARG E 108
ASP E  93
 None
 1.06A 3o7wA-6esqE:
undetectable		 3o7wA-6esqE:
undetectable