SIMILAR PATTERNS OF AMINO ACIDS FOR 3O7W_A_SAMA801

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5l UREASE (BETA
SUBUNIT)
UREASE (ALPHA
SUBUNIT)

(Klebsiella
aerogenes;
Klebsiella
aerogenes) 		PF00699
(Urease_beta)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 ALA B  65
GLY C 100
GLY C  56
ILE C  51
GLU C  41
 None
 1.10A 3o7wA-1a5lB:
undetectable		 3o7wA-1a5lB:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		5 GLY A  87
GLY A  36
LEU A 134
VAL A  62
TYR A  65
 None
 1.08A 3o7wA-1fp3A:
undetectable		 3o7wA-1fp3A:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 ALA A  13
GLY A 287
ILE A 154
LEU A 250
GLU A 204
 None
 1.11A 3o7wA-1jcfA:
undetectable		 3o7wA-1jcfA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 ALA A 110
GLY A  92
ILE A  96
ARG A  76
VAL A  60
 None
 1.06A 3o7wA-1l6wA:
undetectable		 3o7wA-1l6wA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ll8 PAS KINASE

(Homo sapiens) 		PF13426
(PAS_9) 		5 GLY A  85
PHE A  48
ILE A  81
LEU A  31
TYR A  34
 None
 1.08A 3o7wA-1ll8A:
undetectable		 3o7wA-1ll8A:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mb9 BETA-LACTAM
SYNTHETASE

(Streptomyces
clavuligerus) 		PF00733
(Asn_synthase)
PF13537
(GATase_7) 		5 ALA A 433
GLY A 256
ILE A 252
LEU A 408
GLU A 231
 None
 0.92A 3o7wA-1mb9A:
undetectable		 3o7wA-1mb9A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pl8 HUMAN SORBITOL
DEHYDROGENASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 191
GLY A 216
ILE A 215
LEU A 209
ARG A 208
VAL A 201
 None
None
None
None
NAD  A 400 (-3.1A)
None
 1.45A 3o7wA-1pl8A:
4.2		 3o7wA-1pl8A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q2y SIMILAR TO
HYPOTHETICAL
PROTEINS

(Bacillus
subtilis) 		PF13673
(Acetyltransf_10) 		6 ALA A  89
GLY A  55
GLY A  57
ILE A  71
LEU A  74
ARG A  78
 None
 1.49A 3o7wA-1q2yA:
undetectable		 3o7wA-1q2yA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgc PROTEIN (VIRUS
CAPSID PROTEIN VP3)

(Foot-and-mouth
disease virus) 		PF00073
(Rhv) 		5 ALA 3 139
ILE 3 189
LEU 3 199
CYH 3 185
VAL 3 186
 None
 1.01A 3o7wA-1qgc3:
undetectable		 3o7wA-1qgc3:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		5 GLY A 184
ASP A 219
LEU A 218
ARG A 239
VAL A 216
 None
 0.87A 3o7wA-1r8yA:
11.5		 3o7wA-1r8yA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ALA B 546
GLY B 374
GLY B 372
ILE B 747
VAL B 339
 GOL  B3902 (-3.5A)
None
None
None
None
 1.03A 3o7wA-1t3qB:
undetectable		 3o7wA-1t3qB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		5 ALA A 190
GLY A 204
ILE A 148
LEU A 167
VAL A 152
 None
 1.10A 3o7wA-1u5qA:
undetectable		 3o7wA-1u5qA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5i IA-1=SERINE
PROTEINASE INHIBITOR

(Pleurotus
ostreatus) 		no annotation 5 GLY B  43
ILE B   8
LEU B  63
GLU B  15
VAL B  13
 None
None
GOL  B2002 (-3.6A)
None
GOL  B2014 ( 4.7A)
 0.92A 3o7wA-1v5iB:
undetectable		 3o7wA-1v5iB:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		5 ALA A 175
GLY A 179
ILE A 180
ASP A 184
LEU A 185
 None
 0.90A 3o7wA-1vc4A:
undetectable		 3o7wA-1vc4A:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vj0 ALCOHOL
DEHYDROGENASE,
ZINC-CONTAINING

(Thermotoga
maritima) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		6 ALA A 203
GLY A 228
ILE A 227
LEU A 221
ARG A 220
VAL A 213
 None
 1.40A 3o7wA-1vj0A:
5.5		 3o7wA-1vj0A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wf8 NEURABIN-I

(Homo sapiens) 		PF00595
(PDZ) 		5 GLY A  41
GLY A  28
ILE A  27
GLU A  38
VAL A  31
 None
 0.94A 3o7wA-1wf8A:
undetectable		 3o7wA-1wf8A:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xm9 PLAKOPHILIN 1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 570
GLY A 575
ILE A 579
LEU A 607
VAL A 610
 None
 1.12A 3o7wA-1xm9A:
undetectable		 3o7wA-1xm9A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bji INOSITOL-1(OR
4)-MONOPHOSPHATASE

(Bos taurus) 		PF00459
(Inositol_P) 		5 ALA A1204
GLY A1223
GLY A1225
ILE A1226
VAL A1122
 None
 1.12A 3o7wA-2bjiA:
undetectable		 3o7wA-2bjiA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 GLY A  34
GLY A  36
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 ( 3.7A)
NAD  A1378 (-4.1A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.92A 3o7wA-2c5aA:
undetectable		 3o7wA-2c5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5a GDP-MANNOSE-3',
5'-EPIMERASE

(Arabidopsis
thaliana) 		PF01370
(Epimerase) 		5 GLY A  34
GLY A  37
ASP A  78
LEU A  79
ARG A  80
 NAD  A1378 ( 3.7A)
NAD  A1378 (-3.2A)
NAD  A1378 ( 3.8A)
NAD  A1378 (-3.9A)
None
 0.87A 3o7wA-2c5aA:
undetectable		 3o7wA-2c5aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		5 GLY A  90
ILE A  86
ASP A 125
LEU A 126
GLU A 142
 None
 0.94A 3o7wA-2e3zA:
undetectable		 3o7wA-2e3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ebd 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Aquifex
aeolicus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 303
ILE A 115
LEU A 292
GLU A 218
VAL A 219
 None
 1.12A 3o7wA-2ebdA:
undetectable		 3o7wA-2ebdA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 GLY A 224
ASP A 212
LEU A 468
ARG A 467
VAL A 382
 None
 1.06A 3o7wA-2epgA:
undetectable		 3o7wA-2epgA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		5 GLY A  12
GLY A   9
ILE A 122
ARG A  20
VAL A   5
 None
NAP  A1350 (-3.0A)
None
None
None
 0.96A 3o7wA-2f1kA:
2.3		 3o7wA-2f1kA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		5 GLY A 326
ASP A 318
LEU A 313
ARG A 370
VAL A 342
 None
 1.11A 3o7wA-2i0sA:
undetectable		 3o7wA-2i0sA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jis CYSTEINE SULFINIC
ACID DECARBOXYLASE

(Homo sapiens) 		PF00282
(Pyridoxal_deC) 		5 ALA A  32
ILE A 106
LEU A  21
ARG A  22
VAL A  24
 None
 1.09A 3o7wA-2jisA:
undetectable		 3o7wA-2jisA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		7 ALA A  12
GLY A 105
GLY A 107
ASP A 175
LEU A 176
GLU A 201
CYH A 202
 None
 0.51A 3o7wA-2ob1A:
30.8		 3o7wA-2ob1A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob1 LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Saccharomyces
cerevisiae) 		PF04072
(LCM) 		6 ALA A  12
GLY A 105
GLY A 107
GLU A 201
CYH A 202
TYR A 206
 None
 0.60A 3o7wA-2ob1A:
30.8		 3o7wA-2ob1A:
28.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p35 TRANS-ACONITATE
2-METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF13489
(Methyltransf_23) 		5 GLY A  38
GLY A  40
ASP A  83
LEU A  84
VAL A 101
 SAH  A 301 (-3.6A)
SAH  A 301 (-3.3A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.8A)
SAH  A 301 (-4.1A)
 0.40A 3o7wA-2p35A:
10.7		 3o7wA-2p35A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe6 UNCHARACTERIZED
PROTEIN TFU_2867

(Thermobifida
fusca) 		PF04672
(Methyltransf_19) 		5 GLY A  84
GLY A  86
ASP A 135
ARG A 137
TYR A 168
 SAM  A 400 (-3.4A)
SAM  A 400 ( 3.2A)
SAM  A 400 (-3.4A)
SAM  A 400 (-4.6A)
SAM  A 400 ( 4.5A)
 0.39A 3o7wA-2qe6A:
16.1		 3o7wA-2qe6A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vuo IG GAMMA CHAIN C
REGION

(Oryctolagus
cuniculus) 		PF07654
(C1-set) 		5 GLY A 352
PHE A 423
ILE A 441
ASP A 421
VAL A 363
 None
 1.12A 3o7wA-2vuoA:
undetectable		 3o7wA-2vuoA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvl MANNOSYL-3-PHOSPHOGL
YCERATE SYNTHASE

(Thermus
thermophilus) 		PF09488
(Osmo_MPGsynth) 		5 ALA A 253
GLY A 186
ASP A  45
ARG A  49
VAL A  51
 None
 1.12A 3o7wA-2wvlA:
undetectable		 3o7wA-2wvlA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 GLY A 357
GLY A 359
ILE A 361
GLU A 475
TYR A 403
 None
 1.07A 3o7wA-2x40A:
undetectable		 3o7wA-2x40A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xva TELLURITE RESISTANCE
PROTEIN TEHB

(Escherichia
coli) 		PF03848
(TehB) 		5 GLY A  38
GLY A  40
ASP A  86
LEU A  87
VAL A 104
 SFG  A1198 (-4.3A)
SFG  A1198 (-3.2A)
SFG  A1198 (-3.9A)
SFG  A1198 (-3.8A)
SFG  A1198 (-3.8A)
 0.41A 3o7wA-2xvaA:
11.2		 3o7wA-2xvaA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		6 GLY A 115
GLY A 117
ASP A 196
LEU A 197
GLU A 224
TYR A 229
 SAH  A 801 (-3.5A)
SAH  A 801 (-3.4A)
SAH  A 801 (-4.1A)
SAH  A 801 (-3.7A)
SAH  A 801 (-3.0A)
None
 0.56A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahy BETA-GLUCOSIDASE

(Trichoderma
reesei) 		PF00232
(Glyco_hydro_1) 		5 GLY A  86
ILE A  82
ASP A 121
LEU A 122
GLU A 138
 None
 0.91A 3o7wA-3ahyA:
undetectable		 3o7wA-3ahyA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 ALA A 296
GLY A 289
GLY A 291
ILE A 330
ASP A 362
 None
None
None
B12  B 601 (-4.3A)
2A3  A 602 (-3.8A)
 1.04A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 ALA A 296
GLY A 289
GLY A 291
PHE A 329
ILE A 330
 None
None
None
2A3  A 602 (-3.8A)
B12  B 601 (-4.3A)
 0.97A 3o7wA-3anyA:
undetectable		 3o7wA-3anyA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5o CADD-LIKE PROTEIN OF
UNKNOWN FUNCTION

(Nostoc
punctiforme) 		PF12981
(DUF3865) 		5 ALA A  61
GLY A  56
LEU A 123
ARG A 124
VAL A 126
 None
 1.08A 3o7wA-3b5oA:
undetectable		 3o7wA-3b5oA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bkw S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Mesorhizobium
japonicum) 		PF08241
(Methyltransf_11) 		5 GLY A  50
GLY A  52
ASP A  96
LEU A  97
TYR A 118
 None
 0.71A 3o7wA-3bkwA:
12.3		 3o7wA-3bkwA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwc METALLOCARBOXYPEPTID
ASE

(Trypanosoma
cruzi) 		PF02074
(Peptidase_M32) 		5 GLY A 163
ASP A 170
LEU A 169
ARG A 368
VAL A 157
 None
 0.96A 3o7wA-3dwcA:
undetectable		 3o7wA-3dwcA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 ALA A  74
GLY A  14
ASP A  46
LEU A  45
VAL A  33
 NAD  A 400 (-3.8A)
None
None
None
None
 1.06A 3o7wA-3ec7A:
3.4		 3o7wA-3ec7A:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 GLY A 169
ILE A 183
ASP A 159
LEU A 160
ARG A 161
 None
 1.11A 3o7wA-3eqnA:
undetectable		 3o7wA-3eqnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 GLY A 197
ILE A 183
ASP A 159
LEU A 160
ARG A 161
 None
 1.11A 3o7wA-3eqnA:
undetectable		 3o7wA-3eqnA:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8t PREDICTED ATPASE
INVOLVED IN
REPLICATION CONTROL,
CDC46/MCM FAMILY

(Methanopyrus
kandleri) 		PF00493
(MCM) 		5 GLY A 165
PHE A 105
ILE A 119
LEU A  59
GLU A  78
 None
 1.10A 3o7wA-3f8tA:
2.3		 3o7wA-3f8tA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h7a SHORT CHAIN
DEHYDROGENASE

(Rhodopseudomonas
palustris) 		PF00106
(adh_short) 		5 GLY A  12
GLY A  14
ASP A  62
ARG A  64
VAL A  89
 GLY  A  12 ( 0.0A)
GLY  A  14 ( 0.0A)
ASP  A  62 ( 0.6A)
ARG  A  64 ( 0.6A)
VAL  A  89 ( 0.6A)
 0.98A 3o7wA-3h7aA:
undetectable		 3o7wA-3h7aA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		5 ALA A 206
GLY A  62
ILE A 193
LEU A 211
VAL A  53
 None
 1.02A 3o7wA-3ke3A:
3.2		 3o7wA-3ke3A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8k DIHYDROLIPOYL
DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ALA A 266
GLY A 182
ILE A 198
ASP A 172
VAL A 263
 None
 1.12A 3o7wA-3l8kA:
undetectable		 3o7wA-3l8kA:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6z PUTATIVE
IMMUNOGLOBULIN A1
PROTEASE

(Bacteroides
ovatus) 		no annotation 5 ALA A 156
GLY A 202
GLY A 166
ILE A 165
VAL A 228
 None
 1.03A 3o7wA-3n6zA:
undetectable		 3o7wA-3n6zA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		12 ALA A  33
GLY A  98
GLY A 100
PHE A 123
ILE A 126
ASP A 171
LEU A 172
ARG A 173
GLU A 198
CYH A 199
VAL A 200
TYR A 203
 SAM  A 801 (-3.6A)
SAM  A 801 (-3.5A)
SAM  A 801 ( 3.7A)
SAM  A 801 (-3.7A)
SAM  A 801 (-4.3A)
SAM  A 801 (-3.8A)
SAM  A 801 (-3.7A)
None
SAM  A 801 (-3.1A)
SAM  A 801 (-4.9A)
SAM  A 801 ( 3.9A)
SAM  A 801 (-4.6A)
 0.02A 3o7wA-3o7wA:
51.6		 3o7wA-3o7wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pjx CYCLIC DIMERIC GMP
BINDING PROTEIN

(Pseudomonas
fluorescens) 		PF00563
(EAL)
PF00990
(GGDEF) 		5 GLY A 380
PHE A 367
LEU A 254
ARG A 257
GLU A 321
 None
 0.93A 3o7wA-3pjxA:
undetectable		 3o7wA-3pjxA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		5 ALA A  92
GLY A  19
ASP A  49
LEU A  50
VAL A  35
 None
 1.11A 3o7wA-3pk0A:
4.7		 3o7wA-3pk0A:
22.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT L
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation
no annotation 		5 ALA J 110
GLY N 208
GLY N 206
PHE N 169
VAL L 605
 None
 1.10A 3o7wA-3rkoJ:
undetectable		 3o7wA-3rkoJ:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t9y ACETYLTRANSFERASE,
GNAT FAMILY

(Staphylococcus
aureus) 		PF00583
(Acetyltransf_1) 		5 GLY A  61
ILE A  54
ASP A 101
LEU A  98
TYR A  94
 None
None
PGE  A 205 (-4.7A)
None
None
 1.05A 3o7wA-3t9yA:
undetectable		 3o7wA-3t9yA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttl POLYAMINE TRANSPORT
PROTEIN

(Pseudomonas
aeruginosa) 		PF13416
(SBP_bac_8) 		5 ALA A 185
GLY A 238
GLY A 136
ILE A 137
GLU A 181
 None
 0.82A 3o7wA-3ttlA:
undetectable		 3o7wA-3ttlA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw0 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF00092
(VWA) 		5 ALA A 251
GLY A 537
GLY A 535
ASP A 541
ARG A 238
 None
 0.84A 3o7wA-3tw0A:
undetectable		 3o7wA-3tw0A:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uog ALCOHOL
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  53
ASP A  57
LEU A  58
GLU A  51
VAL A  13
 None
 0.89A 3o7wA-3uogA:
3.9		 3o7wA-3uogA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 GLY A  13
GLY A  16
ASP A  52
LEU A  53
ARG A  54
 None
 0.98A 3o7wA-3uxyA:
4.5		 3o7wA-3uxyA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0n POLYKETIDE SYNTHASE
III

(Ectocarpus
siliculosus) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A 200
ILE A 189
ASP A 171
LEU A 157
ARG A 186
 None
 1.11A 3o7wA-4b0nA:
undetectable		 3o7wA-4b0nA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		5 ALA A 320
GLY A 259
ASP A 110
ARG A 109
VAL A 339
 None
 1.07A 3o7wA-4b0sA:
undetectable		 3o7wA-4b0sA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8s ADP-DEPENDENT
GLUCOKINASE

(Thermococcus
litoralis) 		PF04587
(ADP_PFK_GK) 		5 ALA A 215
PHE A 206
ILE A 207
LEU A  81
VAL A  99
 None
None
GLC  A 468 ( 4.3A)
None
None
 1.11A 3o7wA-4b8sA:
2.5		 3o7wA-4b8sA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4em6 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Brucella
melitensis) 		no annotation 5 ALA D 130
GLY D 276
ILE D 203
ASP D 158
VAL D 279
 None
 1.11A 3o7wA-4em6D:
3.5		 3o7wA-4em6D:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grs PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE,
2-DEHYDRO-3-DEOXYPHO
SPHOHEPTONATE
ALDOLASE

(Pyrococcus
furiosus;
Thermotoga
maritima) 		PF00793
(DAHP_synth_1) 		5 GLY A 127
GLY A 100
ASP A 179
ARG A 151
GLU A 105
 None
 1.02A 3o7wA-4grsA:
undetectable		 3o7wA-4grsA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hbz PUTATIVE
PHOSPHOHISTIDINE
PHOSPHATASE, SIXA

(Nakamurella
multipartita) 		PF00300
(His_Phos_1) 		5 ALA A 138
GLY A 145
GLY A 143
LEU A 148
VAL A 129
 None
None
None
PGE  A 203 ( 4.8A)
None
 1.03A 3o7wA-4hbzA:
undetectable		 3o7wA-4hbzA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jwt METHYLTHIOADENOSINE
NUCLEOSIDASE

(Sulfurimonas
denitrificans) 		PF01048
(PNP_UDP_1) 		5 GLY A   7
ILE A  13
LEU A 210
GLU A 171
VAL A  76
 None
None
None
None
ADE  A 305 (-4.8A)
 1.08A 3o7wA-4jwtA:
undetectable		 3o7wA-4jwtA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krg PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Haemonchus
contortus) 		PF08241
(Methyltransf_11) 		6 GLY A  59
GLY A  61
PHE A  81
ASP A 105
ARG A   7
TYR A 127
 SAH  A 502 (-3.6A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.0A)
SAH  A 502 (-3.6A)
SAH  A 502 (-4.9A)
 1.26A 3o7wA-4krgA:
10.0		 3o7wA-4krgA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0d N-ACETYLMURAMIC ACID
6-PHOSPHATE ETHERASE

(Haemophilus
influenzae) 		PF01380
(SIS) 		5 ALA A 182
GLY A 143
ILE A  74
ARG A  70
VAL A 140
 None
 1.11A 3o7wA-4m0dA:
3.4		 3o7wA-4m0dA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		5 GLY A  87
ILE A  83
ASP A 122
LEU A 123
GLU A 139
 None
 0.95A 3o7wA-4mdpA:
undetectable		 3o7wA-4mdpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nji 7-CARBOXY-7-DEAZAGUA
NINE SYNTHASE

(Burkholderia
multivorans) 		PF13394
(Fer4_14) 		5 ALA A   4
GLY A  58
GLY A  61
PHE A   9
ILE A   8
 None
 0.87A 3o7wA-4njiA:
undetectable		 3o7wA-4njiA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2w PUTATIVE
ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Streptococcus
pneumoniae) 		PF01832
(Glucosaminidase) 		5 ALA A 260
GLY A 266
LEU A 137
GLU A 190
TYR A 240
 None
None
None
None
GOL  A 302 (-4.8A)
 1.08A 3o7wA-4q2wA:
undetectable		 3o7wA-4q2wA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdk MAGNESIUM-PROTOPORPH
YRIN
O-METHYLTRANSFERASE

(Synechocystis
sp. PCC 6803) 		PF07109
(Mg-por_mtran_C) 		5 GLY A  70
GLY A  72
ASP A 120
LEU A 121
VAL A 136
 SAH  A 301 (-3.4A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.8A)
SAH  A 301 (-3.6A)
SAH  A 301 (-3.8A)
 1.00A 3o7wA-4qdkA:
11.1		 3o7wA-4qdkA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		5 GLY B 420
ILE B 422
LEU B 269
ARG B 265
VAL B 404
 None
 1.07A 3o7wA-4xmmB:
undetectable		 3o7wA-4xmmB:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zas CALS13

(Micromonospora
echinospora) 		PF01041
(DegT_DnrJ_EryC1) 		5 ALA A  46
GLY A 258
GLY A 261
GLU A  42
VAL A  40
 None
 0.97A 3o7wA-4zasA:
2.6		 3o7wA-4zasA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A  25
GLY A  68
ARG A 110
GLU A  73
VAL A  71
 None
 1.09A 3o7wA-4zyjA:
undetectable		 3o7wA-4zyjA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b47 2-OXOACID--FERREDOXI
N OXIDOREDUCTASE
BETA SUBUNIT

(Sulfurisphaera
tokodaii) 		PF02775
(TPP_enzyme_C)
PF12367
(PFO_beta_C) 		5 ALA B  70
GLY B  93
GLY B  97
ILE B  96
VAL B  88
 None
 1.10A 3o7wA-5b47B:
3.7		 3o7wA-5b47B:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bjx WLAL PROTEIN

(Campylobacter
jejuni) 		no annotation 5 GLY A 480
ILE A 482
LEU A 491
CYH A 428
VAL A 429
 None
 1.11A 3o7wA-5bjxA:
6.4		 3o7wA-5bjxA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		5 GLY A 267
GLY A 270
PHE A 250
ILE A 252
GLU A  51
 GOL  A 401 (-3.2A)
None
None
None
None
 1.02A 3o7wA-5c54A:
undetectable		 3o7wA-5c54A:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9j MRNA CAP GUANINE-N7
METHYLTRANSFERASE,MR
NA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 GLY A 205
GLY A 207
ASP A 261
VAL A 286
TYR A 289
 SAH  A 501 (-3.4A)
SAH  A 501 (-3.4A)
SAH  A 501 (-3.5A)
SAH  A 501 (-4.2A)
SAH  A 501 (-4.0A)
 0.65A 3o7wA-5e9jA:
14.4		 3o7wA-5e9jA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9w MRNA CAP GUANINE-N7
METHYLTRANSFERASE

(Homo sapiens) 		PF03291
(Pox_MCEL) 		5 GLY A 205
GLY A 207
ASP A 261
VAL A 286
TYR A 289
 SAH  A 500 (-3.8A)
SAH  A 500 (-3.5A)
SAH  A 500 (-3.6A)
SAH  A 500 (-3.8A)
SAH  A 500 (-4.0A)
 0.56A 3o7wA-5e9wA:
13.9		 3o7wA-5e9wA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		5 ALA A 143
GLY A 179
GLY A 181
ASP A 229
LEU A 230
 SAH  A 400 ( 4.4A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-4.1A)
SAH  A 400 (-3.2A)
 0.95A 3o7wA-5f8eA:
11.4		 3o7wA-5f8eA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f8e METHYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF13847
(Methyltransf_31) 		5 ALA A 143
GLY A 179
GLY A 181
PHE A 203
LEU A 230
 SAH  A 400 ( 4.4A)
SAH  A 400 (-4.0A)
SAH  A 400 (-3.4A)
SAH  A 400 (-3.6A)
SAH  A 400 (-3.2A)
 1.08A 3o7wA-5f8eA:
11.4		 3o7wA-5f8eA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fif CARBOXYLASE

(Deinococcus
radiodurans) 		PF01039
(Carboxyl_trans) 		5 GLY A 327
GLY A 358
ILE A 354
ASP A 381
VAL A 349
 None
 1.11A 3o7wA-5fifA:
undetectable		 3o7wA-5fifA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4v GLUTAMATE--TRNA
LIGASE

(Xanthomonas
oryzae) 		no annotation 5 ALA A 244
GLY A  18
LEU A  64
VAL A 247
TYR A 250
 None
 1.00A 3o7wA-5h4vA:
undetectable		 3o7wA-5h4vA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 GLY A  87
ILE A  83
ASP A 122
LEU A 123
GLU A 139
 None
 0.99A 3o7wA-5jbkA:
undetectable		 3o7wA-5jbkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbo BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		5 GLY A  92
ILE A  88
ASP A 127
LEU A 128
GLU A 144
 None
 0.91A 3o7wA-5jboA:
undetectable		 3o7wA-5jboA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT ALPHA

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ALA L 249
GLY L 442
GLY L 246
ILE L 245
LEU L 432
 None
 1.02A 3o7wA-5jfcL:
undetectable		 3o7wA-5jfcL:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzx UDP-N-ACETYLENOLPYRU
VOYLGLUCOSAMINE
REDUCTASE

(Mycobacterium
tuberculosis) 		PF01565
(FAD_binding_4)
PF02873
(MurB_C) 		5 ALA A  42
GLY A 132
GLY A 103
GLU A 194
VAL A 192
 None
FAD  A 401 ( 4.0A)
None
None
FAD  A 401 (-3.7A)
 1.02A 3o7wA-5jzxA:
undetectable		 3o7wA-5jzxA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1z AMINODEOXYFUTALOSINE
NUCLEOSIDASE

(Helicobacter
pylori) 		PF01048
(PNP_UDP_1) 		5 GLY A   8
ILE A  14
LEU A 212
GLU A 173
VAL A  78
 None
None
None
None
4CT  A 301 (-4.1A)
 1.06A 3o7wA-5k1zA:
undetectable		 3o7wA-5k1zA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l2r FUMARATE HYDRATASE

(Leishmania
major) 		PF05681
(Fumerase)
PF05683
(Fumerase_C) 		6 ALA A 308
GLY A 318
GLY A 312
ASP A 109
ARG A 112
TYR A 321
 None
 1.44A 3o7wA-5l2rA:
undetectable		 3o7wA-5l2rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lgg ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT
1,ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		5 ALA A  96
GLY A  24
LEU A  76
ARG A  77
GLU A  72
 None
 1.08A 3o7wA-5lggA:
undetectable		 3o7wA-5lggA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 5 GLY A  32
GLY A  28
ILE A  29
ASP A 257
LEU A 260
 None
 0.88A 3o7wA-5nueA:
4.3		 3o7wA-5nueA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5twb FERREDOXIN--NADP
REDUCTASE

(Staphylococcus
aureus) 		PF07992
(Pyr_redox_2) 		5 GLY A 156
ASP A 162
LEU A 161
GLU A 181
VAL A 183
 None
 1.01A 3o7wA-5twbA:
undetectable		 3o7wA-5twbA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vj7 OXIDOREDUCTASE

(Pyrococcus
furiosus) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 ALA A 249
GLY A 443
GLY A 246
ILE A 245
LEU A 433
 None
 1.00A 3o7wA-5vj7A:
undetectable		 3o7wA-5vj7A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wmm NRPS

(Micromonospora
sp. ML1) 		no annotation 5 GLY A 542
GLY A 544
PHE A 564
VAL A 612
TYR A 615
 SAH  A1002 (-3.7A)
SAH  A1002 (-3.4A)
SAH  A1002 (-3.4A)
SAH  A1002 (-4.3A)
SAH  A1002 (-4.8A)
 0.70A 3o7wA-5wmmA:
12.2		 3o7wA-5wmmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp4 PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE
1

(Arabidopsis
thaliana) 		no annotation 6 GLY A  61
GLY A  63
PHE A  83
ASP A 107
ARG A   9
TYR A 131
 SAH  A 701 (-3.4A)
SAH  A 701 (-3.5A)
SAH  A 701 (-3.4A)
SAH  A 701 (-3.2A)
SAH  A 701 (-3.9A)
None
 1.24A 3o7wA-5wp4A:
12.4		 3o7wA-5wp4A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wp5 PHOSPHOMETHYLETHANOL
AMINE
N-METHYLTRANSFERASE
2

(Arabidopsis
thaliana) 		no annotation 6 GLY A  61
GLY A  63
PHE A  83
ASP A 107
ARG A   9
TYR A 131
 SAH  A 502 (-3.4A)
SAH  A 502 (-3.5A)
SAH  A 502 (-3.4A)
SAH  A 502 (-3.2A)
SAH  A 502 (-3.7A)
SAH  A 502 ( 4.8A)
 1.16A 3o7wA-5wp5A:
12.3		 3o7wA-5wp5A:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ar3 GSI-IIC RT

(Geobacillus
stearothermophilus) 		no annotation 5 ALA A  60
GLY A  31
GLY A  28
ASP A  35
TYR A  40
 None
 1.09A 3o7wA-6ar3A:
undetectable		 3o7wA-6ar3A:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT B
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT D

(Pyrococcus
furiosus;
Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation
no annotation 		5 ALA F 139
GLY E  85
PHE E  80
ILE E  83
LEU H 118
 None
 1.11A 3o7wA-6cfwF:
undetectable		 3o7wA-6cfwF:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6din DTDP-4-DEHYDRORHAMNO
SE 3,5-EPIMERASE

(Pseudomonas
aeruginosa) 		no annotation 5 GLY A 119
ASP A  86
LEU A  87
ARG A  88
GLU A 142
 None
 1.04A 3o7wA-6dinA:
undetectable		 3o7wA-6dinA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gnf -

(-) 		no annotation 5 ALA A 350
GLY A 471
ILE A 453
GLU A 465
VAL A 463
 None
 0.97A 3o7wA-6gnfA:
3.6		 3o7wA-6gnfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbg CYANOGENIC
BETA-GLUCOSIDASE

(Trifolium
repens) 		PF00232
(Glyco_hydro_1) 		3 LYS A 478
ARG A 419
ASP A 405
 None
 1.30A 3o7wA-1cbgA:
0.9		 3o7wA-1cbgA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1csj HEPATITIS C VIRUS
RNA POLYMERASE
(NS5B)

(Hepacivirus C) 		PF00998
(RdRP_3) 		3 LYS A  51
ARG A  48
ASP A 352
 None
 1.41A 3o7wA-1csjA:
undetectable		 3o7wA-1csjA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		3 LYS A 518
ARG A 518
ASP A 348
 None
 1.17A 3o7wA-1ewrA:
undetectable		 3o7wA-1ewrA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fps FARNESYL DIPHOSPHATE
SYNTHASE

(Gallus gallus) 		PF00348
(polyprenyl_synt) 		3 LYS A 271
ARG A 126
ASP A 188
 None
 1.32A 3o7wA-1fpsA:
undetectable		 3o7wA-1fpsA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		3 LYS A 240
ARG A 201
ASP A 360
 None
 1.24A 3o7wA-1iqrA:
1.2		 3o7wA-1iqrA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfd INORGANIC
PYROPHOSPHATASE

(Escherichia
coli) 		PF00719
(Pyrophosphatase) 		3 LYS A 142
ARG A  43
ASP A  65
 SO4  A 176 (-2.5A)
SO4  A 176 (-2.8A)
None
 1.41A 3o7wA-1jfdA:
undetectable		 3o7wA-1jfdA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9i ANNEXIN VI

(Homo sapiens) 		PF00191
(Annexin) 		3 LYS A 607
ARG A 624
ASP A 585
 None
 1.08A 3o7wA-1m9iA:
undetectable		 3o7wA-1m9iA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		3 LYS A  61
ARG A  66
ASP A 181
 NLG  A1260 ( 4.4A)
NLG  A1260 (-3.9A)
ADP  A1259 ( 4.9A)
 1.30A 3o7wA-1oh9A:
2.5		 3o7wA-1oh9A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		3 LYS A 197
ARG A  74
ASP A 179
 None
SO3  A1374 (-2.0A)
None
 1.24A 3o7wA-1okgA:
undetectable		 3o7wA-1okgA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3r DISABLED HOMOLOG 2

(Mus musculus) 		PF00640
(PID) 		3 LYS A  90
ARG A  84
ASP A 130
 None
 1.45A 3o7wA-1p3rA:
undetectable		 3o7wA-1p3rA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		3 LYS A 762
ARG A 726
ASP A 372
 None
 1.37A 3o7wA-1taqA:
undetectable		 3o7wA-1taqA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uaz ARCHAERHODOPSIN-1

(Halorubrum
chaoviator) 		PF01036
(Bac_rhodopsin) 		3 LYS A 108
ARG A 169
ASP A  42
 None
 1.03A 3o7wA-1uazA:
undetectable		 3o7wA-1uazA:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjv UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 6

(Saccharomyces
cerevisiae) 		PF00443
(UCH) 		3 LYS A 495
ARG A 129
ASP A 406
 None
 1.39A 3o7wA-1vjvA:
undetectable		 3o7wA-1vjvA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsq MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT

(Escherichia
coli) 		PF03830
(PTSIIB_sorb) 		3 LYS C 274
ARG C 271
ASP C 170
 None
 1.25A 3o7wA-1vsqC:
undetectable		 3o7wA-1vsqC:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		3 LYS C 237
ARG C 412
ASP C 159
 None
 1.35A 3o7wA-2d6fC:
undetectable		 3o7wA-2d6fC:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3z BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF00232
(Glyco_hydro_1) 		3 LYS A 446
ARG A 387
ASP A 375
 None
 1.35A 3o7wA-2e3zA:
undetectable		 3o7wA-2e3zA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gf1 INSULIN-LIKE GROWTH
FACTOR I

(Homo sapiens) 		PF00049
(Insulin) 		3 LYS A  68
ARG A  55
ASP A  20
 None
 1.45A 3o7wA-2gf1A:
undetectable		 3o7wA-2gf1A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ktq PROTEIN (LARGE
FRAGMENT OF DNA
POLYMERASE I)

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF09281
(Taq-exonuc) 		3 LYS A 762
ARG A 726
ASP A 372
 None
 1.43A 3o7wA-2ktqA:
undetectable		 3o7wA-2ktqA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 140
ARG A  43
ASP A  65
 SO4  A 175 (-2.9A)
SO4  A 175 (-3.1A)
None
 1.43A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 148
ARG A  43
ASP A  67
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.37A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2prd PYROPHOSPHATE
PHOSPHOHYDROLASE

(Thermus
thermophilus) 		PF00719
(Pyrophosphatase) 		3 LYS A 148
ARG A  43
ASP A  70
 SO4  A 175 ( 4.5A)
SO4  A 175 (-3.1A)
None
 1.44A 3o7wA-2prdA:
undetectable		 3o7wA-2prdA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q42 PUTATIVE
HYDROXYACYLGLUTATHIO
NE HYDROLASE 2

(Arabidopsis
thaliana) 		PF00753
(Lactamase_B)
PF16123
(HAGH_C) 		3 LYS A 251
ARG A 248
ASP A  11
 ACY  A 800 (-3.1A)
ACY  A 800 (-3.2A)
None
 1.35A 3o7wA-2q42A:
undetectable		 3o7wA-2q42A:
24.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxs INORGANIC
PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00719
(Pyrophosphatase) 		3 LYS A 140
ARG A  37
ASP A  61
 None
PO4  A1167 (-3.7A)
None
 1.33A 3o7wA-2uxsA:
undetectable		 3o7wA-2uxsA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw NRFC PROTEIN
HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus;
Thermus
thermophilus) 		PF13247
(Fer4_11)
PF14589
(NrfD_2) 		3 LYS C   2
ARG B  41
ASP B 103
 None
 1.38A 3o7wA-2vpwC:
undetectable		 3o7wA-2vpwC:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wjf TYROSINE-PROTEIN
PHOSPHATASE CPSB

(Streptococcus
pneumoniae) 		no annotation 3 LYS A   0
ARG A  35
ASP A 215
 None
 1.33A 3o7wA-2wjfA:
undetectable		 3o7wA-2wjfA:
22.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x40 BETA-GLUCOSIDASE

(Thermotoga
neapolitana) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		3 LYS A 427
ARG A 454
ASP A 477
 None
 1.20A 3o7wA-2x40A:
undetectable		 3o7wA-2x40A:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdp LYSINE-SPECIFIC
DEMETHYLASE 4C

(Homo sapiens) 		PF09465
(LBR_tudor) 		3 LYS A 888
ARG A 890
ASP A 914
 None
 1.25A 3o7wA-2xdpA:
undetectable		 3o7wA-2xdpA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xy1 NEURAL CELL ADHESION
MOLECULE 2

(Homo sapiens) 		PF07679
(I-set) 		3 LYS A 371
ARG A 353
ASP A 339
 None
 1.29A 3o7wA-2xy1A:
undetectable		 3o7wA-2xy1A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3a PHOSPHATIDYLINOSITOL
-4,5-BISPHOSPHATE
3-KINASE CATALYTIC
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd)
PF02192
(PI3K_p85B) 		3 LYS A 185
ARG A 890
ASP A 818
 None
 1.42A 3o7wA-2y3aA:
undetectable		 3o7wA-2y3aA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 LYS A  38
ARG A  88
ASP A 144
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
None
 1.25A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		3 LYS A  38
ARG A  88
ASP A 146
 SAH  A 801 (-2.8A)
SAH  A 801 (-3.9A)
SAH  A 801 (-2.9A)
 0.31A 3o7wA-2zwaA:
27.9		 3o7wA-2zwaA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abz BETA-GLUCOSIDASE I

(Kluyveromyces
marxianus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF07691
(PA14)
PF14310
(Fn3-like) 		3 LYS A 280
ARG A 276
ASP A 214
 None
 1.42A 3o7wA-3abzA:
undetectable		 3o7wA-3abzA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		3 LYS A  63
ARG A 314
ASP A 303
 None
 1.41A 3o7wA-3adpA:
4.1		 3o7wA-3adpA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		3 LYS X 235
ARG X 237
ASP X 316
 None
 1.35A 3o7wA-3dwoX:
undetectable		 3o7wA-3dwoX:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		3 LYS A 862
ARG A 870
ASP A 173
 GOL  A2003 (-3.5A)
GOL  A2003 (-4.7A)
None
 1.28A 3o7wA-3ecqA:
undetectable		 3o7wA-3ecqA:
11.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egi TRIMETHYLGUANOSINE
SYNTHASE HOMOLOG

(Homo sapiens) 		PF09445
(Methyltransf_15) 		3 LYS A 796
ARG A 792
ASP A 747
 None
None
ADP  A   3 (-3.4A)
 1.46A 3o7wA-3egiA:
9.0		 3o7wA-3egiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		3 LYS A 914
ARG A1036
ASP A 801
 None
 1.16A 3o7wA-3egwA:
4.2		 3o7wA-3egwA:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f81 DUAL SPECIFICITY
PROTEIN PHOSPHATASE
3

(Homo sapiens) 		PF00782
(DSPc) 		3 LYS A 182
ARG A 176
ASP A 107
 None
 1.25A 3o7wA-3f81A:
undetectable		 3o7wA-3f81A:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fho ATP-DEPENDENT RNA
HELICASE DBP5

(Schizosaccharomyces
pombe) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		3 LYS A 325
ARG A 480
ASP A 417
 None
 1.45A 3o7wA-3fhoA:
3.1		 3o7wA-3fhoA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		3 LYS A 125
ARG A 124
ASP A 256
 None
 1.26A 3o7wA-3fxgA:
undetectable		 3o7wA-3fxgA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h32 FIBRINOGEN ALPHA
CHAIN
FIBRINOGEN BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF08702
(Fib_alpha)
PF00147
(Fibrinogen_C)
PF08702
(Fib_alpha) 		3 LYS A 157
ARG B 415
ASP A 146
 None
 1.45A 3o7wA-3h32A:
undetectable		 3o7wA-3h32A:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h39 TRNA NUCLEOTIDYL
TRANSFERASE-RELATED
PROTEIN

(Thermotoga
maritima) 		PF01743
(PolyA_pol)
PF12627
(PolyA_pol_RNAbd) 		3 LYS A 223
ARG A 180
ASP A  46
 ATP  A 501 (-3.5A)
ATP  A 501 (-3.3A)
None
 1.37A 3o7wA-3h39A:
undetectable		 3o7wA-3h39A:
25.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i4q APC40078

(Oleispira
antarctica) 		PF00719
(Pyrophosphatase) 		3 LYS A 143
ARG A  44
ASP A  66
 None
None
NA  A 176 (-2.9A)
 1.36A 3o7wA-3i4qA:
undetectable		 3o7wA-3i4qA:
23.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kez PUTATIVE SUGAR
BINDING PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 339
ARG A 357
ASP A 321
 None
 1.27A 3o7wA-3kezA:
undetectable		 3o7wA-3kezA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ld3 INORGANIC
PYROPHOSPHATASE

(Anaplasma
phagocytophilum) 		PF00719
(Pyrophosphatase) 		3 LYS A 149
ARG A  44
ASP A  68
 PO4  A 200 ( 4.9A)
PO4  A 200 (-3.2A)
None
 1.44A 3o7wA-3ld3A:
undetectable		 3o7wA-3ld3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 357
ARG A 375
ASP A 327
 None
 1.36A 3o7wA-3mcxA:
undetectable		 3o7wA-3mcxA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwt NUCLEOPROTEIN

(Lassa
mammarenavirus) 		PF00843
(Arena_nucleocap)
PF17290
(Arena_ncap_C) 		3 LYS A 488
ARG A 492
ASP A 466
 None
 1.30A 3o7wA-3mwtA:
undetectable		 3o7wA-3mwtA:
22.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o7w LEUCINE CARBOXYL
METHYLTRANSFERASE 1

(Homo sapiens) 		PF04072
(LCM) 		3 LYS A  37
ARG A  73
ASP A 122
 SAM  A 801 (-2.6A)
SAM  A 801 (-3.8A)
SAM  A 801 (-2.7A)
 0.01A 3o7wA-3o7wA:
51.6		 3o7wA-3o7wA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqn CONSERVED DOMAIN
PROTEIN

(Enterococcus
faecalis) 		PF05043
(Mga) 		3 LYS A 128
ARG A 124
ASP A  13
 None
 1.42A 3o7wA-3sqnA:
undetectable		 3o7wA-3sqnA:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttf TRANSCRIPTIONAL
REGULATORY PROTEIN

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		3 LYS A 243
ARG A 245
ASP A 424
 None
 1.34A 3o7wA-3ttfA:
undetectable		 3o7wA-3ttfA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		3 LYS A  18
ARG A  15
ASP A 364
 None
 1.41A 3o7wA-3ummA:
undetectable		 3o7wA-3ummA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wi5 MAJOR OUTER MEMBRANE
PROTEIN P.IB

(Neisseria
meningitidis) 		PF00267
(Porin_1) 		3 LYS A  99
ARG A 125
ASP A 108
 FLC  A 401 (-3.4A)
FLC  A 401 (-3.7A)
None
 1.00A 3o7wA-3wi5A:
undetectable		 3o7wA-3wi5A:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wjo OCTAPRENYL
DIPHOSPHATE SYNTHASE

(Escherichia
coli) 		PF00348
(polyprenyl_synt) 		3 LYS A  45
ARG A  48
ASP A  85
 IPE  A 402 (-3.0A)
IPE  A 402 (-2.9A)
None
 1.11A 3o7wA-3wjoA:
undetectable		 3o7wA-3wjoA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 LYS A 706
ARG A 679
ASP A 489
 None
 0.98A 3o7wA-3zifA:
undetectable		 3o7wA-3zifA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		3 LYS A 853
ARG A 987
ASP A1151
 None
None
C  R   9 ( 2.8A)
 1.44A 3o7wA-4bocA:
undetectable		 3o7wA-4bocA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ddw REVERSE GYRASE

(Thermotoga
maritima) 		PF00270
(DEAD)
PF01131
(Topoisom_bac)
PF01751
(Toprim) 		3 LYS A1024
ARG A 853
ASP A 594
 None
 1.42A 3o7wA-4ddwA:
undetectable		 3o7wA-4ddwA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4geq KINETOCHORE PROTEIN
SPC25
KINETOCHORE PROTEIN
SPC24

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		no annotation
PF08286
(Spc24) 		3 LYS B 185
ARG B 183
ASP A 215
 None
None
GOL  B 301 (-3.3A)
 1.09A 3o7wA-4geqB:
undetectable		 3o7wA-4geqB:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		3 LYS A 421
ARG A 408
ASP A 208
 None
 1.29A 3o7wA-4ifpA:
undetectable		 3o7wA-4ifpA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4law PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
FKBP4

(Homo sapiens) 		PF00254
(FKBP_C) 		3 LYS A 138
ARG A  52
ASP A 147
 None
 1.09A 3o7wA-4lawA:
undetectable		 3o7wA-4lawA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdp BETA-GLUCOSIDASE

(Humicola grisea) 		PF00232
(Glyco_hydro_1) 		3 LYS A 459
ARG A 399
ASP A 387
 None
 1.32A 3o7wA-4mdpA:
undetectable		 3o7wA-4mdpA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mq0 PARKIA BIGLOBOSA
LECTIN (PBL)

(Parkia
biglobosa) 		PF01419
(Jacalin) 		3 LYS A  63
ARG A  60
ASP A  88
 None
 1.06A 3o7wA-4mq0A:
undetectable		 3o7wA-4mq0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzy PROBABLE THYMIDYLATE
KINASE

(Sulfurisphaera
tokodaii) 		PF02223
(Thymidylate_kin) 		3 LYS A 147
ARG A 144
ASP A  92
 None
 1.11A 3o7wA-4nzyA:
undetectable		 3o7wA-4nzyA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o5p UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF09994
(DUF2235) 		3 LYS A 291
ARG A 720
ASP A 583
 None
 1.21A 3o7wA-4o5pA:
undetectable		 3o7wA-4o5pA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 3 LYS B 192
ARG B 189
ASP B  94
 None
 1.44A 3o7wA-4p37B:
undetectable		 3o7wA-4p37B:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r04 TOXIN A

(Clostridioides
difficile) 		PF11713
(Peptidase_C80)
PF12918
(TcdB_N)
PF12919
(TcdA_TcdB)
PF12920
(TcdA_TcdB_pore) 		3 LYS A 565
ARG A 747
ASP A 590
 None
 1.37A 3o7wA-4r04A:
undetectable		 3o7wA-4r04A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r3u 2-HYDROXYISOBUTYRYL-
COA MUTASE LARGE
SUBUNIT

(Aquincola
tertiaricarbonis) 		PF01642
(MM_CoA_mutase) 		3 LYS A  35
ARG A  34
ASP A 294
 None
 1.02A 3o7wA-4r3uA:
undetectable		 3o7wA-4r3uA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1c EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT C

(Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF05470
(eIF-3c_N) 		3 LYS C 382
ARG C 603
ASP C 305
 None
 1.04A 3o7wA-4u1cC:
undetectable		 3o7wA-4u1cC:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3C

(Lachancea
kluyveri) 		PF00189
(Ribosomal_S3_C)
PF07650
(KH_2) 		3 LYS c 382
ARG c 603
ASP c 305
 None
 1.04A 3o7wA-4uerc:
undetectable		 3o7wA-4uerc:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		3 LYS A 805
ARG A 769
ASP A 393
 None
 1.46A 3o7wA-4uqgA:
undetectable		 3o7wA-4uqgA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4utf GLYCOSYL HYDROLASE
FAMILY 71

(Bacteroides
xylanisolvens) 		PF16317
(Glyco_hydro_99) 		3 LYS A 379
ARG A 376
ASP A 187
 None
 1.30A 3o7wA-4utfA:
undetectable		 3o7wA-4utfA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wx6 PROTEASE

(Human
mastadenovirus
D) 		PF00770
(Peptidase_C5) 		3 LYS A 173
ARG A 169
ASP A 142
 None
 1.17A 3o7wA-4wx6A:
undetectable		 3o7wA-4wx6A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-TRIPHOSPHATE
SYNTHASE SUBUNIT
PHNI
ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli;
Escherichia
coli) 		PF05861
(PhnI)
PF06007
(PhnJ) 		3 LYS D  87
ARG D  83
ASP C  13
 None
 1.27A 3o7wA-4xb6D:
undetectable		 3o7wA-4xb6D:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4za2 2-DEOXY-D-GLUCONATE
3-DEHYDROGENASE

(Pectobacterium
carotovorum) 		PF13561
(adh_short_C2) 		3 LYS A 107
ARG A  97
ASP A  65
 None
 1.44A 3o7wA-4za2A:
5.5		 3o7wA-4za2A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ady GTPASE HFLX

(Escherichia
coli) 		PF01926
(MMR_HSR1)
PF13167
(GTP-bdg_N)
PF16360
(GTP-bdg_M) 		3 LYS 6 336
ARG 6 331
ASP 6 243
 None
 1.01A 3o7wA-5ady6:
undetectable		 3o7wA-5ady6:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bn4 V-TYPE ATP SYNTHASE
ALPHA CHAIN
NEQ263

(Nanoarchaeum
equitans;
Nanoarchaeum
equitans) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N)
PF16886
(ATP-synt_ab_Xtn)
PF00006
(ATP-synt_ab) 		3 LYS A 411
ARG A 485
ASP B 369
 None
 1.19A 3o7wA-5bn4A:
undetectable		 3o7wA-5bn4A:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bv9 CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Bacillus
pumilus) 		PF02011
(Glyco_hydro_48) 		3 LYS A 600
ARG A 597
ASP A 115
 None
CA  A 801 ( 4.7A)
None
 1.38A 3o7wA-5bv9A:
undetectable		 3o7wA-5bv9A:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		3 LYS B 374
ARG B 356
ASP B 237
 None
 1.39A 3o7wA-5c24B:
undetectable		 3o7wA-5c24B:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 291
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.45A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cux ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
cruzi) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 328
 POP  A 802 (-3.1A)
PO4  A 805 (-3.7A)
None
 1.35A 3o7wA-5cuxA:
undetectable		 3o7wA-5cuxA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 323
 None
 0.94A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuy ACIDOCALCISOMAL
PYROPHOSPHATASE

(Trypanosoma
brucei) 		PF00719
(Pyrophosphatase) 		3 LYS A 237
ARG A 259
ASP A 328
 None
None
MG  A 902 (-4.3A)
 1.25A 3o7wA-5cuyA:
undetectable		 3o7wA-5cuyA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dt5 BETA-GLUCOSIDASE

(Exiguobacterium
antarcticum) 		PF00232
(Glyco_hydro_1) 		3 LYS A 427
ARG A 369
ASP A 409
 None
 1.42A 3o7wA-5dt5A:
undetectable		 3o7wA-5dt5A:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT THETA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		3 LYS q  93
ARG q  73
ASP q 205
 None
 1.12A 3o7wA-5gw5q:
undetectable		 3o7wA-5gw5q:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdh TOLL-LIKE RECEPTOR 8

(Homo sapiens) 		PF13855
(LRR_8) 		3 LYS A  91
ARG A 128
ASP A  43
 None
 1.43A 3o7wA-5hdhA:
undetectable		 3o7wA-5hdhA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ifm NON-POU
DOMAIN-CONTAINING
OCTAMER-BINDING
PROTEIN

(Homo sapiens) 		PF00076
(RRM_1)
PF08075
(NOPS) 		3 LYS A 190
ARG A 153
ASP A 286
 None
 1.42A 3o7wA-5ifmA:
undetectable		 3o7wA-5ifmA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im3 RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Pseudomonas
aeruginosa) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		3 LYS A 795
ARG A 210
ASP A 305
 None
 1.23A 3o7wA-5im3A:
undetectable		 3o7wA-5im3A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iwl 5F9 DIABODY

(Homo sapiens) 		no annotation 3 LYS B  63
ARG B  38
ASP B 123
 None
 1.41A 3o7wA-5iwlB:
undetectable		 3o7wA-5iwlB:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbk BETA-GLUCOSIDASE

(Trichoderma
harzianum) 		PF00232
(Glyco_hydro_1) 		3 LYS A 449
ARG A 389
ASP A 377
 None
 1.35A 3o7wA-5jbkA:
undetectable		 3o7wA-5jbkA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		3 LYS A 414
ARG A 459
ASP A 512
 None
 1.10A 3o7wA-5jouA:
undetectable		 3o7wA-5jouA:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldt MOMP PORIN

(Campylobacter
jejuni) 		PF05538
(Campylo_MOMP) 		3 LYS A  43
ARG A 398
ASP A 155
 None
None
CA  A 501 (-3.3A)
 1.38A 3o7wA-5ldtA:
undetectable		 3o7wA-5ldtA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls0 SOLUBLE INORGANIC
PYROPHOSPHATASE 1

(Arabidopsis
thaliana) 		PF00719
(Pyrophosphatase) 		3 LYS A 173
ARG A  76
ASP A  98
 None
 1.26A 3o7wA-5ls0A:
undetectable		 3o7wA-5ls0A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lx8 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		3 LYS A 398
ARG A 424
ASP A 356
 None
 1.28A 3o7wA-5lx8A:
undetectable		 3o7wA-5lx8A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 3 LYS A 347
ARG A 344
ASP A 318
 None
None
MG  A 701 (-2.5A)
 1.22A 3o7wA-5m6gA:
2.1		 3o7wA-5m6gA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngk GLUCOSYLCERAMIDASE

(Bacteroides
thetaiotaomicron) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		3 LYS A 427
ARG A 491
ASP A 116
 None
 1.21A 3o7wA-5ngkA:
undetectable		 3o7wA-5ngkA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o32 COMPLEMENT FACTOR I

(Homo sapiens) 		PF00057
(Ldl_recept_a)
PF00530
(SRCR) 		3 LYS D 319
ARG D 315
ASP D 289
 None
None
CA  D 401 (-3.3A)
 1.06A 3o7wA-5o32D:
undetectable		 3o7wA-5o32D:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0F02343P
KLLA0E05809P

(Kluyveromyces
lactis;
Kluyveromyces
lactis) 		PF05859
(Mis12)
PF03980
(Nnf1) 		3 LYS B 114
ARG A 105
ASP A 116
 None
 1.43A 3o7wA-5t58B:
undetectable		 3o7wA-5t58B:
23.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		3 LYS C3257
ARG C2962
ASP C3181
 None
 1.42A 3o7wA-5y3rC:
undetectable		 3o7wA-5y3rC:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7i CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 2

(Oreochromis
mossambicus) 		no annotation 3 LYS A 187
ARG A  35
ASP A 111
 None
 1.43A 3o7wA-5y7iA:
undetectable		 3o7wA-5y7iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0u NEOPULLULANASE 1

(Thermoactinomyces
vulgaris) 		no annotation 3 LYS A 385
ARG A 381
ASP A 128
 None
 1.13A 3o7wA-5z0uA:
undetectable		 3o7wA-5z0uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6esq PFAM DUF35

(Methanothermococcus
thermolithotrophicus) 		no annotation 3 LYS E 124
ARG E 108
ASP E  93
 None
 1.06A 3o7wA-6esqE:
undetectable		 3o7wA-6esqE:
undetectable