SIMILAR PATTERNS OF AMINO ACIDS FOR 3O14_A_NIOA300_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b41 ACETYLCHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		4 ALA A 397
VAL A 378
VAL A 401
LEU A 398
 None
 0.86A 3o14A-1b41A:
0.0		 3o14A-1b41A:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ARG A  76
SER A  83
VAL A  85
VAL A  98
 None
 0.85A 3o14A-1bbuA:
0.0		 3o14A-1bbuA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bs9 ACETYL XYLAN
ESTERASE

(Talaromyces
purpureogenus) 		PF01083
(Cutinase) 		4 ALA A 198
VAL A  85
VAL A 202
LEU A 199
 None
 0.78A 3o14A-1bs9A:
0.0		 3o14A-1bs9A:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ARG A  76
SER A  83
VAL A  85
VAL A  98
 None
 0.86A 3o14A-1e1tA:
0.0		 3o14A-1e1tA:
18.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e3h GUANOSINE
PENTAPHOSPHATE
SYNTHETASE

(Streptomyces
antibioticus) 		PF00013
(KH_1)
PF01138
(RNase_PH)
PF03726
(PNPase) 		4 SER A 364
VAL A 361
VAL A 377
LEU A 375
 None
 0.82A 3o14A-1e3hA:
0.1		 3o14A-1e3hA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h3m 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Escherichia
coli) 		PF01128
(IspD) 		4 ALA A 107
VAL A  54
VAL A  42
LEU A  38
 None
 0.84A 3o14A-1h3mA:
undetectable		 3o14A-1h3mA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hds HEMOGLOBIN S (DEOXY)
(BETA CHAIN)

(Odocoileus
virginianus) 		PF00042
(Globin) 		4 ALA B  26
VAL B  17
VAL B 113
LEU B 109
 None
 0.75A 3o14A-1hdsB:
undetectable		 3o14A-1hdsB:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j8s PYELONEPHRITIC
ADHESIN

(Escherichia
coli) 		PF03627
(PapG_N) 		4 ARG A 161
ALA A  37
VAL A   5
VAL A  39
 None
 0.81A 3o14A-1j8sA:
0.0		 3o14A-1j8sA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jtd BETA-LACTAMASE
INHIBITOR PROTEIN II

(Streptomyces
exfoliatus) 		PF13540
(RCC1_2) 		4 ALA B 281
VAL B 292
VAL B 279
LEU B 272
 None
 0.86A 3o14A-1jtdB:
0.0		 3o14A-1jtdB:
23.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kmq TRANSFORMING PROTEIN
RHOA

(Homo sapiens) 		PF00071
(Ras) 		4 ALA A  44
VAL A  48
VAL A  53
LEU A  55
 None
 0.88A 3o14A-1kmqA:
0.0		 3o14A-1kmqA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lzk HEROIN ESTERASE

(Rhodococcus sp.) 		PF07859
(Abhydrolase_3) 		4 ALA A 114
VAL A  65
VAL A 116
LEU A  83
 None
 0.85A 3o14A-1lzkA:
undetectable		 3o14A-1lzkA:
24.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0s RIBOSE-5-PHOSPHATE
ISOMERASE A

(Haemophilus
influenzae) 		PF06026
(Rib_5-P_isom_A) 		4 ALA A  14
VAL A  24
VAL A  18
LEU A  15
 None
 0.60A 3o14A-1m0sA:
undetectable		 3o14A-1m0sA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m41 FMNH2-DEPENDENT
ALKANESULFONATE
MONOOXYGENASE

(Escherichia
coli) 		PF00296
(Bac_luciferase) 		4 ARG A 127
SER A  80
VAL A 120
VAL A  81
 None
 0.83A 3o14A-1m41A:
undetectable		 3o14A-1m41A:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ALA A 669
VAL A 823
VAL A 671
LEU A 635
 None
 0.79A 3o14A-1n5xA:
undetectable		 3o14A-1n5xA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 ALA B 148
SER B 215
VAL B 213
VAL B 150
 None
 0.87A 3o14A-1nvmB:
undetectable		 3o14A-1nvmB:
24.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 ARG A  39
ARG A  45
ALA A 342
VAL A 349
 EPS  A5001 (-2.8A)
EPS  A5001 ( 2.7A)
FMN  A4001 (-3.5A)
None
 0.80A 3o14A-1qxoA:
undetectable		 3o14A-1qxoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rcq CATABOLIC ALANINE
RACEMASE DADX

(Pseudomonas
aeruginosa) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		5 ALA A 314
SER A 318
VAL A 320
VAL A 239
LEU A 308
 None
 1.34A 3o14A-1rcqA:
undetectable		 3o14A-1rcqA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tua HYPOTHETICAL PROTEIN
APE0754

(Aeropyrum
pernix) 		PF00013
(KH_1) 		4 SER A  70
VAL A  66
VAL A  17
LEU A  14
 None
 0.88A 3o14A-1tuaA:
undetectable		 3o14A-1tuaA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvp CELLULASE

(Pseudoalteromonas
haloplanktis) 		PF00150
(Cellulase) 		4 ALA A  58
VAL A 128
VAL A  85
LEU A  81
 None
 0.81A 3o14A-1tvpA:
undetectable		 3o14A-1tvpA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0l PROBABLE GTPASE ENGC

(Thermotoga
maritima) 		PF03193
(RsgA_GTPase)
PF16745
(RsgA_N) 		4 ARG A  67
ALA A  77
VAL A  49
VAL A   9
 None
 0.86A 3o14A-1u0lA:
undetectable		 3o14A-1u0lA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5k HYPOTHETICAL PROTEIN

(Deinococcus
radiodurans) 		PF02565
(RecO_C)
PF11967
(RecO_N) 		4 ARG A   8
ALA A  69
VAL A  58
VAL A  71
 None
 0.88A 3o14A-1u5kA:
undetectable		 3o14A-1u5kA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE ALPHA
SUBUNIT

(Klebsiella
oxytoca) 		PF02286
(Dehydratase_LU) 		4 ALA A 418
VAL A 473
VAL A 422
LEU A 419
 None
 0.84A 3o14A-1uc4A:
undetectable		 3o14A-1uc4A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ux7 ENDO-1,4-BETA-XYLANA
SE D

(Paenibacillus
polymyxa) 		PF03422
(CBM_6) 		4 ALA A 122
VAL A  61
VAL A 124
LEU A  39
 None
 0.85A 3o14A-1ux7A:
undetectable		 3o14A-1ux7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 ALA A  45
VAL A  37
VAL A  41
LEU A  25
 None
 0.83A 3o14A-1v9aA:
undetectable		 3o14A-1v9aA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vdc NADPH DEPENDENT
THIOREDOXIN
REDUCTASE

(Arabidopsis
thaliana) 		PF07992
(Pyr_redox_2) 		4 ALA A 283
VAL A 278
VAL A 281
LEU A 110
 None
 0.76A 3o14A-1vdcA:
undetectable		 3o14A-1vdcA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve2 UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 ALA A  46
VAL A  38
VAL A  42
LEU A  26
 None
 0.74A 3o14A-1ve2A:
undetectable		 3o14A-1ve2A:
23.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ven BETA-AMYLASE

(Bacillus cereus) 		PF00686
(CBM_20)
PF01373
(Glyco_hydro_14) 		4 ARG A 204
VAL A 207
VAL A 217
LEU A 225
 None
 0.82A 3o14A-1venA:
undetectable		 3o14A-1venA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ARG A 373
ALA A  10
VAL A   8
LEU A 252
 None
 0.79A 3o14A-1vftA:
undetectable		 3o14A-1vftA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wba WINGED BEAN ALBUMIN
1

(Psophocarpus
tetragonolobus) 		PF00197
(Kunitz_legume) 		4 ARG A 155
SER A  45
VAL A  47
VAL A  33
 None
 0.82A 3o14A-1wbaA:
undetectable		 3o14A-1wbaA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wkc HB8 TT1367 PROTEIN

(Thermus
thermophilus) 		PF01812
(5-FTHF_cyc-lig) 		4 ALA A 137
VAL A 169
VAL A 139
LEU A 105
 None
 0.80A 3o14A-1wkcA:
undetectable		 3o14A-1wkcA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl7 ARABINANASE-TS

(Geobacillus
thermodenitrificans) 		PF04616
(Glyco_hydro_43) 		5 ARG A 208
ALA A 281
VAL A 206
VAL A 274
LEU A 303
 None
 1.02A 3o14A-1wl7A:
undetectable		 3o14A-1wl7A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzo HPCE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase) 		4 ALA A 116
VAL A 102
VAL A 120
LEU A 117
 None
 0.82A 3o14A-1wzoA:
undetectable		 3o14A-1wzoA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvs MHC CLASS I ANTIGEN

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A 202
ALA A 246
VAL A 194
VAL A 248
 None
 0.74A 3o14A-1zvsA:
undetectable		 3o14A-1zvsA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zzg GLUCOSE-6-PHOSPHATE
ISOMERASE

(Thermus
thermophilus) 		PF00342
(PGI) 		4 ARG A   7
ALA A 363
VAL A 361
LEU A 310
 None
 0.76A 3o14A-1zzgA:
undetectable		 3o14A-1zzgA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a2d N-ACETYLGALACTOSAMIN
E KINASE

(Homo sapiens) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ALA A 226
SER A 410
VAL A 412
VAL A 224
 None
 0.88A 3o14A-2a2dA:
undetectable		 3o14A-2a2dA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 350
VAL A 345
VAL A 348
LEU A 180
 None
 0.70A 3o14A-2c3dA:
undetectable		 3o14A-2c3dA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfu PROBABLE
2-HYDROXYHEPTA-2,4-D
IENE-1,7-DIOATE
ISOMERASE

(Thermus
thermophilus) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		4 ALA A 133
VAL A 119
VAL A 137
LEU A 134
 None
 0.76A 3o14A-2dfuA:
undetectable		 3o14A-2dfuA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2di7 BK158_1

(Homo sapiens) 		PF00630
(Filamin) 		4 ALA A  65
VAL A  73
VAL A  63
LEU A  98
 None
 0.76A 3o14A-2di7A:
undetectable		 3o14A-2di7A:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e7u GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Thermus
thermophilus) 		PF00202
(Aminotran_3) 		4 ALA A 276
VAL A 108
VAL A 262
LEU A 264
 None
 0.77A 3o14A-2e7uA:
undetectable		 3o14A-2e7uA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eq9 PYRUVATE
DEHYDROGENASE
COMPLEX,
DIHYDROLIPOAMIDE
DEHYDROGENASE E3
COMPONENT

(Thermus
thermophilus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 311
VAL A 306
VAL A 309
LEU A 145
 None
 0.76A 3o14A-2eq9A:
undetectable		 3o14A-2eq9A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2euh NADP DEPENDENT NON
PHOSPHORYLATING
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Streptococcus
mutans) 		PF00171
(Aldedh) 		5 ALA A 137
SER A 469
VAL A 467
VAL A 139
LEU A 123
 None
 1.11A 3o14A-2euhA:
undetectable		 3o14A-2euhA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f06 CONSERVED
HYPOTHETICAL PROTEIN

(Bacteroides
thetaiotaomicron) 		no annotation 4 ALA A  82
VAL A 130
VAL A  86
LEU A  83
 HIS  A 152 (-3.8A)
None
None
HIS  A 152 (-3.7A)
 0.83A 3o14A-2f06A:
undetectable		 3o14A-2f06A:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT C
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Staphylococcus
aureus) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02686
(Glu-tRNAGln)
PF02934
(GatB_N) 		4 SER B 137
VAL B 139
VAL C  91
LEU A 339
 None
 0.64A 3o14A-2f2aB:
undetectable		 3o14A-2f2aB:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		4 ALA A 170
SER A 256
VAL A 258
VAL A 168
 None
 0.88A 3o14A-2f6gA:
undetectable		 3o14A-2f6gA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gq3 MALATE SYNTHASE G

(Mycobacterium
tuberculosis) 		PF01274
(Malate_synthase) 		4 ALA A 141
VAL A 526
VAL A 147
LEU A 142
 None
 0.51A 3o14A-2gq3A:
undetectable		 3o14A-2gq3A:
17.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gz3 ASPARTATE
BETA-SEMIALDEHYDE
DEHYDROGENASE

(Streptococcus
pneumoniae) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A 136
VAL A 269
VAL A 140
LEU A 137
 None
 0.83A 3o14A-2gz3A:
0.9		 3o14A-2gz3A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hru PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE II

(Thermotoga
maritima) 		PF00586
(AIRS)
PF02769
(AIRS_C)
PF16904
(PurL_C) 		4 ALA A 389
SER A 401
VAL A 502
VAL A 391
 None
 0.70A 3o14A-2hruA:
undetectable		 3o14A-2hruA:
17.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF

(Allochromatium
vinosum) 		PF02635
(DrsE) 		4 ALA B 225
VAL B 241
VAL B 229
LEU B 226
 None
 0.88A 3o14A-2hy5B:
undetectable		 3o14A-2hy5B:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jsz PROBABLE THIOL
PEROXIDASE

(Bacillus
subtilis) 		PF08534
(Redoxin) 		4 ALA A 128
SER A 130
VAL A  51
LEU A 127
 None
 0.77A 3o14A-2jszA:
undetectable		 3o14A-2jszA:
24.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k1g LIPOPROTEIN SPR

(Escherichia
coli) 		PF00877
(NLPC_P60) 		4 SER A  69
VAL A 120
VAL A  72
LEU A  84
 None
 0.58A 3o14A-2k1gA:
undetectable		 3o14A-2k1gA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ot9 HYPOTHETICAL PROTEIN

(Pseudomonas
syringae group
genomosp. 3) 		PF07152
(YaeQ) 		4 ALA A 130
VAL A 170
VAL A 132
LEU A 105
 None
 0.80A 3o14A-2ot9A:
undetectable		 3o14A-2ot9A:
24.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ott T-CELL SURFACE
GLYCOPROTEIN CD5

(Homo sapiens) 		PF00530
(SRCR) 		4 SER X  11
VAL X   9
VAL X  26
LEU X  35
 None
 0.88A 3o14A-2ottX:
undetectable		 3o14A-2ottX:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ALA A 266
VAL A 172
VAL A 227
LEU A 267
 None
 0.87A 3o14A-2rb9A:
undetectable		 3o14A-2rb9A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgj FLAVIN-CONTAINING
MONOOXYGENASE

(Pseudomonas
aeruginosa) 		PF01494
(FAD_binding_3) 		4 SER A 241
VAL A 239
VAL A 244
LEU A 247
 None
 0.80A 3o14A-2rgjA:
undetectable		 3o14A-2rgjA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rjt BETA-KETOACYL-ACP
SYNTHASE II

(Streptococcus
pneumoniae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A 341
SER A 235
VAL A  13
VAL A 345
LEU A 338
 None
 1.43A 3o14A-2rjtA:
undetectable		 3o14A-2rjtA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6o THIOREDOXIN
GLUTATHIONE
REDUCTASE

(Schistosoma
mansoni) 		PF00462
(Glutaredoxin)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 430
VAL A 425
VAL A 428
LEU A 255
 None
 0.80A 3o14A-2v6oA:
undetectable		 3o14A-2v6oA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 ALA A 278
SER A 256
VAL A 253
LEU A 282
 None
 0.83A 3o14A-2vn7A:
undetectable		 3o14A-2vn7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vut NITROGEN METABOLITE
REPRESSION REGULATOR
NMRA

(Aspergillus
nidulans) 		PF05368
(NmrA) 		4 ALA A 150
SER A 111
VAL A 148
LEU A 218
 NAD  A1353 (-3.7A)
None
None
None
 0.77A 3o14A-2vutA:
undetectable		 3o14A-2vutA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Pseudomonas
aeruginosa) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		4 ALA A   5
VAL A 163
VAL A   7
LEU A 176
 None
 0.86A 3o14A-2x3eA:
undetectable		 3o14A-2x3eA:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4l FERRIC-SIDEROPHORE
RECEPTOR PROTEIN

(Streptomyces
coelicolor) 		PF01497
(Peripla_BP_2) 		4 ALA A 216
VAL A 225
VAL A 254
LEU A 213
 None
 0.59A 3o14A-2x4lA:
undetectable		 3o14A-2x4lA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xiv HYPOTHETICAL
INVASION PROTEIN

(Mycobacterium
tuberculosis) 		PF00877
(NLPC_P60) 		4 SER A 384
VAL A 433
VAL A 387
LEU A 398
 None
 0.76A 3o14A-2xivA:
undetectable		 3o14A-2xivA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yzm D-ALANINE--D-ALANINE
LIGASE

(Thermus
thermophilus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 ALA A 179
SER A 164
VAL A 166
VAL A 152
LEU A 176
 None
 1.43A 3o14A-2yzmA:
undetectable		 3o14A-2yzmA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3adp LAMBDA-CRYSTALLIN

(Oryctolagus
cuniculus) 		PF00725
(3HCDH)
PF02737
(3HCDH_N) 		4 ALA A 144
SER A 120
VAL A 118
LEU A 158
 None
 0.88A 3o14A-3adpA:
undetectable		 3o14A-3adpA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bil PROBABLE LACI-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Corynebacterium
glutamicum) 		PF13407
(Peripla_BP_4) 		4 ALA A 241
VAL A 272
VAL A 270
LEU A 237
 None
 0.79A 3o14A-3bilA:
undetectable		 3o14A-3bilA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e8j COPROPORPHYRINOGEN
III OXIDASE

(Leishmania
naiffi) 		PF01218
(Coprogen_oxidas) 		4 ARG A  48
ARG A  46
VAL A  61
VAL A  92
 None
 0.85A 3o14A-3e8jA:
undetectable		 3o14A-3e8jA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		4 ALA A  14
VAL A  24
VAL A  18
LEU A  15
 None
 0.55A 3o14A-3enqA:
undetectable		 3o14A-3enqA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f8r THIOREDOXIN
REDUCTASE (TRXB-3)

(Sulfolobus
solfataricus) 		PF07992
(Pyr_redox_2) 		4 ALA A 284
VAL A 279
VAL A 282
LEU A 119
 None
 0.80A 3o14A-3f8rA:
undetectable		 3o14A-3f8rA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fha ENDO-BETA-N-ACETYLGL
UCOSAMINIDASE

(Glutamicibacter
protophormiae) 		PF03644
(Glyco_hydro_85) 		4 ALA A 267
VAL A 280
VAL A 269
LEU A 296
 None
 0.88A 3o14A-3fhaA:
undetectable		 3o14A-3fhaA:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwz INNER MEMBRANE
PROTEIN YBAL

(Escherichia
coli) 		PF02254
(TrkA_N) 		4 ALA A 482
VAL A 414
VAL A 444
LEU A 421
 None
 0.82A 3o14A-3fwzA:
undetectable		 3o14A-3fwzA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g2f BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ALA A 400
VAL A 387
VAL A 404
LEU A 401
 EDO  A   5 (-3.4A)
None
None
CAS  A 397 ( 3.6A)
 0.83A 3o14A-3g2fA:
undetectable		 3o14A-3g2fA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hs0 COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2) 		4 ALA A 551
SER B 771
VAL A 553
LEU B 740
 None
 0.82A 3o14A-3hs0A:
undetectable		 3o14A-3hs0A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igz COFACTOR-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Leishmania
mexicana) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		4 ALA B  81
VAL B  57
VAL B 528
LEU B  82
 None
 0.86A 3o14A-3igzB:
undetectable		 3o14A-3igzB:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3it4 ARGININE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
ARGJ ALPHA CHAIN

(Mycobacterium
tuberculosis) 		PF01960
(ArgJ) 		4 ALA A  40
VAL A  16
VAL A  42
LEU A  82
 None
 0.80A 3o14A-3it4A:
undetectable		 3o14A-3it4A:
27.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jsk CYPBP37 PROTEIN

(Neurospora
crassa) 		PF01946
(Thi4) 		5 ALA A 320
SER A  93
VAL A  97
VAL A 324
LEU A 321
 None
 1.22A 3o14A-3jskA:
undetectable		 3o14A-3jskA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		5 ALA A 126
SER A 123
VAL A 216
VAL A 121
LEU A 127
 None
 1.32A 3o14A-3k2dA:
undetectable		 3o14A-3k2dA:
24.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7c PUTATIVE NTF2-LIKE
TRANSPEPTIDASE

(Campylobacter
jejuni) 		PF12870
(DUF4878) 		4 ALA A  81
VAL A  85
VAL A  99
LEU A 101
 None
PGE  A 117 (-4.6A)
PGE  A 117 (-4.6A)
None
 0.74A 3o14A-3k7cA:
undetectable		 3o14A-3k7cA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke3 PUTATIVE
SERINE-PYRUVATE
AMINOTRANSFERASE

(Psychrobacter
arcticus) 		PF00266
(Aminotran_5) 		4 ARG A 239
ALA A  51
VAL A  53
LEU A 211
 ACT  A 383 (-3.5A)
ACT  A 383 ( 3.7A)
None
None
 0.79A 3o14A-3ke3A:
undetectable		 3o14A-3ke3A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyo MHC CLASS I ANTIGEN

(Homo sapiens) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A 202
ALA A 246
VAL A 194
VAL A 248
 None
 0.73A 3o14A-3kyoA:
undetectable		 3o14A-3kyoA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 315
VAL A 310
VAL A 313
LEU A 148
 None
 0.73A 3o14A-3ladA:
undetectable		 3o14A-3ladA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		4 ARG A 129
SER A 216
VAL A 214
VAL A 225
 None
 0.64A 3o14A-3lyrA:
undetectable		 3o14A-3lyrA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m49 TRANSKETOLASE

(Bacillus
anthracis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 546
VAL A 583
VAL A 545
LEU A 527
 None
 0.84A 3o14A-3m49A:
undetectable		 3o14A-3m49A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcs PUTATIVE
MONOOXYGENASE

(Fusobacterium
nucleatum) 		PF03992
(ABM) 		4 ALA A  45
SER A  55
VAL A  14
LEU A 204
 None
 0.87A 3o14A-3mcsA:
undetectable		 3o14A-3mcsA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mln TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF16422
(COE1_DBD) 		4 ARG A 129
SER A 216
VAL A 214
VAL A 225
 None
 0.72A 3o14A-3mlnA:
undetectable		 3o14A-3mlnA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlp TRANSCRIPTION FACTOR
COE1

(Mus musculus) 		PF01833
(TIG)
PF16422
(COE1_DBD)
PF16423
(COE1_HLH) 		4 ARG A 129
SER A 216
VAL A 214
VAL A 225
 None
 0.49A 3o14A-3mlpA:
undetectable		 3o14A-3mlpA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS

(Escherichia
coli) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		4 ALA A 250
VAL A 155
VAL A 252
LEU A 245
 None
 0.86A 3o14A-3mmpA:
undetectable		 3o14A-3mmpA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc4 OXIDOREDUCTASE,
PYRIDINE
NUCLEOTIDE-DISULFIDE
FAMILY

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 ALA A 274
VAL A 269
VAL A 272
LEU A 107
 None
 0.65A 3o14A-3oc4A:
undetectable		 3o14A-3oc4A:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ALA A  87
VAL A  96
VAL A  94
LEU A  88
 None
 0.83A 3o14A-3om9A:
undetectable		 3o14A-3om9A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prx COBRA VENOM FACTOR

(Naja kaouthia) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ALA B 573
SER B 793
VAL B 575
LEU B 762
 None
 0.81A 3o14A-3prxB:
4.7		 3o14A-3prxB:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pty ARABINOSYLTRANSFERAS
E C

(Mycobacterium
tuberculosis) 		PF14896
(Arabino_trans_C) 		4 SER A1047
VAL A1045
VAL A 757
LEU A 971
 None
 0.82A 3o14A-3ptyA:
1.5		 3o14A-3ptyA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwg MAJOR
HISTOCOMPATIBILITY
COMPLEX CLASS I

(Macaca mulatta) 		PF00129
(MHC_I)
PF07654
(C1-set) 		4 ARG A 202
ALA A 246
VAL A 194
VAL A 248
 None
 0.65A 3o14A-3rwgA:
undetectable		 3o14A-3rwgA:
23.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 ALA C 669
VAL C 823
VAL C 671
LEU C 635
 None
 0.76A 3o14A-3sr6C:
undetectable		 3o14A-3sr6C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sul CERATO-PLATANIN-LIKE
PROTEIN

(Moniliophthora
perniciosa) 		PF07249
(Cerato-platanin) 		4 SER A  57
VAL A  59
VAL A  55
LEU A 135
 None
 0.87A 3o14A-3sulA:
undetectable		 3o14A-3sulA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ty7 PUTATIVE ALDEHYDE
DEHYDROGENASE
SAV2122

(Staphylococcus
aureus) 		PF00171
(Aldedh) 		4 ALA A 396
VAL A 411
VAL A 422
LEU A 393
 None
 0.69A 3o14A-3ty7A:
undetectable		 3o14A-3ty7A:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u95 GLYCOSIDE HYDROLASE,
FAMILY 4

(Thermotoga
neapolitana) 		PF02056
(Glyco_hydro_4)
PF11975
(Glyco_hydro_4C) 		4 ALA A  14
VAL A  64
VAL A  18
LEU A  15
 None
 0.85A 3o14A-3u95A:
undetectable		 3o14A-3u95A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 SER A  73
VAL A  75
VAL A  82
LEU A 671
 None
 0.80A 3o14A-3wonA:
undetectable		 3o14A-3wonA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 ARG A 453
ALA A 437
SER A 482
VAL A 480
 None
 0.79A 3o14A-3zz1A:
undetectable		 3o14A-3zz1A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a63 APOPTOSIS
STIMULATING OF P53
PROTEIN 2

(Homo sapiens) 		PF00018
(SH3_1)
PF12796
(Ank_2) 		4 ALA B1029
VAL B1050
VAL B1018
LEU B 996
 None
 0.85A 3o14A-4a63B:
undetectable		 3o14A-4a63B:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7k ALDOS-2-ULOSE
DEHYDRATASE

(Phanerochaete
chrysosporium) 		no annotation 4 ALA A 779
VAL A 826
VAL A 777
LEU A 764
 None
 0.84A 3o14A-4a7kA:
undetectable		 3o14A-4a7kA:
15.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at0 3-KETOSTEROID-DELTA4
-5ALPHA-DEHYDROGENAS
E

(Rhodococcus
jostii) 		PF00890
(FAD_binding_2) 		4 ALA A 453
VAL A 216
VAL A 236
LEU A 238
 None
 0.85A 3o14A-4at0A:
undetectable		 3o14A-4at0A:
19.25