SIMILAR PATTERNS OF AMINO ACIDS FOR 3O0Q_B_ADNB1004

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		9 MET A 212
ASN A 242
SER A 244
ASP A 295
CYH A 322
PRO A 490
SER A 596
THR A 598
THR A 626
 None
None
None
None
GDP  A1002 (-3.6A)
GDP  A1002 (-3.9A)
None
None
None
 0.55A 3o0qB-1xjeA:
63.7		 3o0qB-1xjeA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pba UNCHARACTERIZED
PROTEIN ABASI

(Acinetobacter
baumannii) 		no annotation 5 ASP B 300
PRO B 240
SER B 239
THR B 237
THR B 246
 None
 1.39A 3o0qB-4pbaB:
0.5		 3o0qB-4pbaB:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn4 NICASTRIN

(Homo sapiens) 		PF05450
(Nicastrin) 		5 ASN A 450
SER A 135
ASP A 458
PRO A 424
THR A 334
 None
 1.45A 3o0qB-5fn4A:
3.1		 3o0qB-5fn4A:
22.05