SIMILAR PATTERNS OF AMINO ACIDS FOR 3O0M_A_ACTA146

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1de6 L-RHAMNOSE ISOMERASE

(Escherichia
coli) 		PF06134
(RhaA) 		4 ASP A  30
GLU A  32
GLU A  33
ARG A  36
 None
 1.24A 3o0mA-1de6A:
0.0		 3o0mA-1de6A:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		4 ASP A  67
GLU A  72
GLU A  70
ARG A  73
 None
 1.41A 3o0mA-1h09A:
0.0		 3o0mA-1h09A:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vwk DNA POLYMERASE

(Thermococcus
gorgonarius) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 ASP A 635
GLU A 637
GLU A 638
ARG A 641
 None
 0.81A 3o0mA-2vwkA:
0.3		 3o0mA-2vwkA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9s D-ARABINOSE
ISOMERASE

(Aeribacillus
pallidus) 		PF02952
(Fucose_iso_C)
PF07881
(Fucose_iso_N1)
PF07882
(Fucose_iso_N2) 		4 ASP A 228
GLU A 230
GLU A 231
ARG A 234
 None
 1.20A 3o0mA-3a9sA:
0.0		 3o0mA-3a9sA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyw NUCLEOSOME ASSEMBLY
PROTEIN 1, PUTATIVE

(Plasmodium
falciparum) 		PF00956
(NAP) 		4 ASP A 119
GLU A 118
GLU A 122
ARG A 108
 None
 1.44A 3o0mA-3gywA:
0.1		 3o0mA-3gywA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		4 ASP A1095
GLU A1097
GLU A1098
ARG A1101
 None
 1.33A 3o0mA-3nyfA:
0.0		 3o0mA-3nyfA:
18.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o0m HIT FAMILY PROTEIN

(Mycolicibacterium
smegmatis) 		PF01230
(HIT) 		4 ASP A 124
GLU A 126
GLU A 127
ARG A 130
 ACT  A 146 (-2.8A)
None
None
ACT  A 146 (-2.9A)
 0.00A 3o0mA-3o0mA:
30.4		 3o0mA-3o0mA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zo9 TREHALOSE
SYNTHASE/AMYLASE
TRES

(Mycolicibacterium
smegmatis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 ASP A 342
GLU A 343
GLU A 272
ARG A 228
 CL  A1587 ( 4.4A)
CL  A1587 (-4.9A)
None
CL  A1587 (-3.0A)
 1.22A 3o0mA-3zo9A:
1.0		 3o0mA-3zo9A:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4z DNA POLYMERASE IV

(Sulfolobus
acidocaldarius;
Sulfolobus
solfataricus) 		no annotation 4 ASP B 167
GLU B 169
GLU B 170
ARG B 173
 None
 1.17A 3o0mA-4f4zB:
0.4		 3o0mA-4f4zB:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j25 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
putida) 		PF13640
(2OG-FeII_Oxy_3) 		4 ASP A 107
GLU A 109
GLU A 106
ARG A 133
 None
 1.03A 3o0mA-4j25A:
undetectable		 3o0mA-4j25A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n49 CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1

(Homo sapiens) 		PF01728
(FtsJ) 		4 ASP A 210
GLU A 212
GLU A 213
ARG A 216
 None
 0.66A 3o0mA-4n49A:
undetectable		 3o0mA-4n49A:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rb0 DNA-BINDING
TRANSCRIPTIONAL DUAL
REGULATOR OF
SIDEROPHORE
BIOSYNTHESIS AND
TRANSPORT(FUR
FAMILY)

(Magnetospirillum
gryphiswaldense) 		PF01475
(FUR) 		4 ASP A  35
GLU A  37
GLU A  38
ARG A  41
 None
 1.02A 3o0mA-4rb0A:
undetectable		 3o0mA-4rb0A:
26.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uul L-LACTATE
DEHYDROGENASE

(Trichomonas
vaginalis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 ASP A 319
GLU A 188
GLU A 323
ARG A  97
 None
 1.38A 3o0mA-4uulA:
undetectable		 3o0mA-4uulA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w4l PPE FAMILY PROTEIN
PPE41

(Mycobacterium
tuberculosis) 		PF00823
(PPE) 		4 ASP B 144
GLU B   4
GLU B 148
ARG B 151
 None
 1.32A 3o0mA-4w4lB:
undetectable		 3o0mA-4w4lB:
26.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h2t TREHALOSE SYNTHASE

(Thermomonospora
curvata) 		no annotation 4 ASP A 329
GLU A 330
GLU A 259
ARG A 215
 None
 1.38A 3o0mA-5h2tA:
undetectable		 3o0mA-5h2tA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0j ADP-DEPENDENT
GLUCOKINASE

(Pyrococcus
horikoshii) 		no annotation 4 ASP A  16
GLU A  12
GLU A  19
ARG A 388
 None
 1.39A 3o0mA-5o0jA:
undetectable		 3o0mA-5o0jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyo HEEH_RD4_0097

(Escherichia) 		no annotation 4 ASP A  22
GLU A  24
GLU A  25
ARG A  28
 None
 1.28A 3o0mA-5uyoA:
undetectable		 3o0mA-5uyoA:
18.00