SIMILAR PATTERNS OF AMINO ACIDS FOR 3NYA_A_JTZA1203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5f MONOCLONAL
ANTI-E-SELECTIN 7A9
ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 200
ASN H 162
 None
 1.40A 3nyaA-1a5fH:
undetectable		 3nyaA-1a5fH:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehl ANTI-(6-4)
PHOTOPRODUCT
ANTIBODY 64M-2 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.41A 3nyaA-1ehlH:
undetectable		 3nyaA-1ehlH:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eo8 ANTIBODY (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.43A 3nyaA-1eo8H:
undetectable		 3nyaA-1eo8H:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpt IGG2A-KAPPA C3 FAB
(HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 189
SER H 187
ASN H 209
ASN H 162
 None
 1.42A 3nyaA-1fptH:
undetectable		 3nyaA-1fptH:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 168
VAL C 186
SER C 184
ASN C 201
ASN C 160
 None
 1.39A 3nyaA-1fskC:
undetectable		 3nyaA-1fskC:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h0d ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.44A 3nyaA-1h0dB:
undetectable		 3nyaA-1h0dB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9i RECOMBINANT
MONOCLONAL
ANTI-TESTOSTERONE
FAB FRAGMENT HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.35A 3nyaA-1i9iH:
undetectable		 3nyaA-1i9iH:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnh MONOCLONAL
ANTI-ESTRADIOL
10G6D6 FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 168
VAL B 186
SER B 184
ASN B 201
ASN B 160
 None
 1.40A 3nyaA-1jnhB:
undetectable		 3nyaA-1jnhB:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kb5 ANTIBODY DESIRE-1

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.30A 3nyaA-1kb5H:
undetectable		 3nyaA-1kb5H:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfa MONOCLONAL ANTIBODY
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 176
VAL H 194
SER H 192
ASN H 209
ASN H 168
 None
 1.32A 3nyaA-1kfaH:
undetectable		 3nyaA-1kfaH:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ngq N1G9 (IGG1-LAMBDA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.39A 3nyaA-1ngqH:
undetectable		 3nyaA-1ngqH:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ob1 ANTIBODY, LIGHT
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.38A 3nyaA-1ob1B:
undetectable		 3nyaA-1ob1B:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz5 HEAVY CHAIN OF FAB
(SYA/J6)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.43A 3nyaA-1pz5B:
undetectable		 3nyaA-1pz5B:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rur IMMUNOGLOBULIN 13G5,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.41A 3nyaA-1rurH:
undetectable		 3nyaA-1rurH:
16.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t66 IMMUNOGLOBULIN HEAVY
CHAIN

(Mus musculus) 		no annotation 5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.43A 3nyaA-1t66H:
undetectable		 3nyaA-1t66H:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1un1 XYLOGLUCAN
ENDOTRANSGLYCOSYLASE

(Populus tremula) 		PF00722
(Glyco_hydro_16)
PF06955
(XET_C) 		5 VAL A 143
SER A  57
SER A 131
PHE A  90
PHE A  88
 None
 1.37A 3nyaA-1un1A:
undetectable		 3nyaA-1un1A:
20.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xgy K42-41L FAB HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.42A 3nyaA-1xgyH:
undetectable		 3nyaA-1xgyH:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ajx ANTIBODY 7A1 FAB'

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.43A 3nyaA-2ajxH:
undetectable		 3nyaA-2ajxH:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		5 VAL A 201
SER A 211
PHE A 241
PHE A 226
TYR A 232
 None
 1.43A 3nyaA-2douA:
undetectable		 3nyaA-2douA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g60 ANTI-FLAG M2 FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 171
VAL H 191
SER H 189
ASN H 209
ASN H 162
 None
 1.42A 3nyaA-2g60H:
undetectable		 3nyaA-2g60H:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gfn HTH-TYPE
TRANSCRIPTIONAL
REGULATOR PKSA
RELATED PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF13977
(TetR_C_6) 		5 THR A 166
ASP A 167
VAL A 163
PHE A 128
TYR A 112
 None
 1.33A 3nyaA-2gfnA:
undetectable		 3nyaA-2gfnA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vxt MURINE IGG 125-2H

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.42A 3nyaA-2vxtH:
undetectable		 3nyaA-2vxtH:
17.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9d ICSM 18-ANTI-PRP
THERAPEUTIC FAB
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.42A 3nyaA-2w9dH:
undetectable		 3nyaA-2w9dH:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zch MONOCLONAL ANTIBODY
8G8F5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.42A 3nyaA-2zchH:
undetectable		 3nyaA-2zchH:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bqu 3H6 FAB HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 174
VAL D 192
SER D 190
ASN D 207
ASN D 166
 None
 1.39A 3nyaA-3bquD:
undetectable		 3nyaA-3bquD:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cvh 25-D1.16 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.41A 3nyaA-3cvhH:
undetectable		 3nyaA-3cvhH:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g04 HUMAN THYROID
STIMULATING
AUTOANTIBODY M22
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 182
SER B 180
ASN B 197
ASN B 155
 None
 1.43A 3nyaA-3g04B:
undetectable		 3nyaA-3g04B:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gnm JAA-F11 FAB ANTIBODY
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
 1.43A 3nyaA-3gnmH:
undetectable		 3nyaA-3gnmH:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2c CNTO4088 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.43A 3nyaA-3i2cH:
undetectable		 3nyaA-3i2cH:
17.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		6 ASP A 110
VAL A 111
SER A 192
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 1.07A 3nyaA-3pblA:
37.3		 3nyaA-3pblA:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pbl D(3) DOPAMINE
RECEPTOR, LYSOZYME
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 ASP A 110
VAL A 111
SER A 192
SER A 196
PHE A 345
PHE A 346
TYR A 373
 ETQ  A1200 (-3.5A)
ETQ  A1200 (-3.4A)
ETQ  A1200 (-3.3A)
ETQ  A1200 ( 4.6A)
ETQ  A1200 (-4.4A)
ETQ  A1200 ( 4.5A)
ETQ  A1200 (-4.4A)
 0.81A 3nyaA-3pblA:
37.3		 3nyaA-3pblA:
56.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A 109
ASP A 113
VAL A 114
SER A 207
PHE A 289
ASN A 312
TYR A 316
 None
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-3.0A)
None
 1.19A 3nyaA-3pdsA:
47.1		 3nyaA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
PHE A 290
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
ERC  A1201 (-2.8A)
ERC  A1201 (-4.8A)
None
 1.40A 3nyaA-3pdsA:
47.1		 3nyaA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.8A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.67A 3nyaA-3pdsA:
47.1		 3nyaA-3pdsA:
99.56
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pds FUSION PROTEIN
BETA-2 ADRENERGIC
RECEPTOR/LYSOZYME

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		11 TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 207
PHE A 289
PHE A 290
ASN A 293
ASN A 312
TYR A 316
 None
ERC  A1201 ( 4.6A)
ERC  A1201 (-3.7A)
ERC  A1201 (-3.8A)
None
ERC  A1201 (-2.7A)
ERC  A1201 (-4.5A)
ERC  A1201 (-4.8A)
ERC  A1201 (-3.5A)
ERC  A1201 (-3.0A)
None
 0.56A 3nyaA-3pdsA:
47.1		 3nyaA-3pdsA:
99.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ra7 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 175
VAL H 193
SER H 191
ASN H 208
ASN H 167
 None
 1.41A 3nyaA-3ra7H:
undetectable		 3nyaA-3ra7H:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sdi PROTEASOME COMPONENT
PRE5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		5 THR E 219
VAL E  47
SER E  42
ASN E 185
TYR E 224
 None
 1.39A 3nyaA-3sdiE:
undetectable		 3nyaA-3sdiE:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sge HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 165
VAL H 183
SER H 181
ASN H 198
ASN H 157
 None
 1.39A 3nyaA-3sgeH:
undetectable		 3nyaA-3sgeH:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujt AB-52 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.43A 3nyaA-3ujtH:
undetectable		 3nyaA-3ujtH:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ulv FAB12 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 172
VAL D 191
SER D 189
ASN D 206
ASN D 164
 None
 1.39A 3nyaA-3ulvD:
undetectable		 3nyaA-3ulvD:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfh MAB FAB H FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 167
VAL A 185
SER A 183
ASN A 200
ASN A 159
 None
 1.43A 3nyaA-3wfhA:
undetectable		 3nyaA-3wfhA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ag4 MONOCLONAL ANTIBODY
3E3 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.40A 3nyaA-4ag4H:
undetectable		 3nyaA-4ag4H:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edx HEAVY CHAIN OF FAB
OF MURINE ANTI-NGF

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 171
VAL B 191
SER B 189
ASN B 209
ASN B 162
 None
 1.39A 3nyaA-4edxB:
undetectable		 3nyaA-4edxB:
17.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		9 TRP A 109
THR A 110
ASP A 113
VAL A 114
SER A 203
PHE A 261
PHE A 262
ASN A 284
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 1.15A 3nyaA-4gbrA:
40.8		 3nyaA-4gbrA:
57.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4gbr BETA-2 ADRENERGIC
RECEPTOR

(Homo sapiens) 		PF00001
(7tm_1) 		12 TRP A 109
THR A 110
ASP A 113
VAL A 114
VAL A 117
SER A 203
SER A 207
PHE A 261
PHE A 262
ASN A 265
ASN A 284
TYR A 288
 None
CAU  A 500 ( 4.0A)
CAU  A 500 (-3.0A)
CAU  A 500 (-3.5A)
CAU  A 500 (-4.2A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.1A)
CAU  A 500 (-4.2A)
CAU  A 500 (-4.6A)
CAU  A 500 (-3.4A)
CAU  A 500 (-3.3A)
CAU  A 500 (-4.6A)
 0.47A 3nyaA-4gbrA:
40.8		 3nyaA-4gbrA:
57.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3r HEAVY CHAIN OF
VRC-PG04 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.41A 3nyaA-4i3rH:
undetectable		 3nyaA-4i3rH:
17.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 TRP A 131
ASP A 135
VAL A 136
PHE A 340
PHE A 341
ASN A 344
TYR A 370
 None
ERM  A2001 (-3.2A)
ERM  A2001 (-3.8A)
ERM  A2001 (-4.3A)
None
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.8A)
 0.56A 3nyaA-4ib4A:
27.5		 3nyaA-4ib4A:
31.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8r HEAVY CHAIN OF POM2
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 162
VAL B 180
SER B 178
ASN B 195
ASN B 154
 None
 1.43A 3nyaA-4j8rB:
undetectable		 3nyaA-4j8rB:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo2 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R56 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 159
VAL H 178
SER H 176
ASN H 190
ASN H 151
 None
 1.43A 3nyaA-4jo2H:
undetectable		 3nyaA-4jo2H:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo3 MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY R20 HEAVY
CHAIN

(Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.43A 3nyaA-4jo3H:
undetectable		 3nyaA-4jo3H:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3e BOVINE ANTIBODY WITH
ULTRALONG CDR H3,
HEAVY CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 196
ASN H 155
 None
 1.41A 3nyaA-4k3eH:
undetectable		 3nyaA-4k3eH:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpp PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF01699
(Na_Ca_ex) 		5 THR A  36
VAL A 224
SER A 254
PHE A  85
ASN A 103
 None
 1.27A 3nyaA-4kppA:
undetectable		 3nyaA-4kppA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvc IG HEAVY CHAIN V
REGION MOPC 21, IGH
PROTEIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.43A 3nyaA-4kvcH:
undetectable		 3nyaA-4kvcH:
17.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		7 TRP A1109
THR A1110
ASP A1113
VAL A1114
SER A1203
PHE A1290
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.9A)
None
 1.12A 3nyaA-4ldeA:
34.0		 3nyaA-4ldeA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
PHE A1289
PHE A1290
ASN A1293
ASN A1312
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 0.60A 3nyaA-4ldeA:
34.0		 3nyaA-4ldeA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		10 TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
SER A1203
PHE A1289
PHE A1290
ASN A1312
TYR A1316
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.9A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-2.9A)
None
 0.70A 3nyaA-4ldeA:
34.0		 3nyaA-4ldeA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		9 TRP A1109
THR A1110
ASP A1113
VAL A1114
VAL A1117
SER A1207
PHE A1289
PHE A1290
ASN A1293
 None
P0G  A1401 ( 3.9A)
P0G  A1401 (-2.9A)
P0G  A1401 (-3.7A)
P0G  A1401 ( 4.4A)
P0G  A1401 (-2.8A)
P0G  A1401 ( 4.7A)
P0G  A1401 ( 4.9A)
P0G  A1401 (-3.0A)
 0.83A 3nyaA-4ldeA:
34.0		 3nyaA-4ldeA:
49.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4lde LYSOZYME, BETA-2
ADRENERGIC RECEPTOR

(Escherichia
virus T4;
Homo sapiens) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		5 VAL A1114
PHE A1289
ASN A1293
ASN A1312
TYR A1316
 P0G  A1401 (-3.7A)
P0G  A1401 ( 4.7A)
P0G  A1401 (-3.0A)
P0G  A1401 (-2.9A)
None
 1.30A 3nyaA-4ldeA:
34.0		 3nyaA-4ldeA:
49.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p37 PUTATIVE POLY(A)
POLYMERASE CATALYTIC
SUBUNIT

(Megavirus
chiliensis) 		no annotation 5 THR B 145
VAL B 147
VAL B 151
PHE B 326
PHE B 377
 None
 1.35A 3nyaA-4p37B:
undetectable		 3nyaA-4p37B:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pb9 AB64 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 181
SER H 179
ASN H 196
ASN H 155
 None
 1.43A 3nyaA-4pb9H:
undetectable		 3nyaA-4pb9H:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4py8 ANTIBODY 3.1 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL I 168
VAL I 187
SER I 185
ASN I 202
ASN I 160
 None
 1.40A 3nyaA-4py8I:
undetectable		 3nyaA-4py8I:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q6i HEAVY CHAIN OF
MURINE 2D5 FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 163
VAL B 181
SER B 179
ASN B 196
ASN B 155
 None
 1.40A 3nyaA-4q6iB:
undetectable		 3nyaA-4q6iB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnr PGT130 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.43A 3nyaA-4rnrA:
undetectable		 3nyaA-4rnrA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi5 FAB-94 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR D 168
VAL D 171
VAL D 190
SER D 188
ASN D 205
 None
 1.20A 3nyaA-4xi5D:
undetectable		 3nyaA-4xi5D:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxb FAB 83-7 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 168
VAL A 186
SER A 184
ASN A 201
ASN A 160
 None
 1.42A 3nyaA-4zxbA:
undetectable		 3nyaA-4zxbA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b3j FAB, HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL E 172
VAL E 190
SER E 188
ASN E 205
ASN E 164
 None
 1.41A 3nyaA-5b3jE:
undetectable		 3nyaA-5b3jE:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b6f ANTI-LEUKOTRIENE C4
MONOCLONAL ANTIBODY
IMMUNOGLOBULIN
GAMMA1 HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL B 187
VAL B 205
SER B 203
ASN B 220
ASN B 179
 None
 1.43A 3nyaA-5b6fB:
undetectable		 3nyaA-5b6fB:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cck ANTIBODY 3BC315 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.40A 3nyaA-5cckH:
undetectable		 3nyaA-5cckH:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dur HEAVY CHAIN OF
ANTIBODY 100F4

(Homo sapiens) 		no annotation 5 VAL H 171
VAL H 190
SER H 188
ASN H 205
ASN H 163
 None
 1.38A 3nyaA-5durH:
undetectable		 3nyaA-5durH:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elg GLUTATHIONE
S-TRANSFERASE DHAR1,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 THR A 198
ASP A  19
VAL A 203
PHE A 103
PHE A 106
 None
GOL  A 301 (-2.9A)
None
None
None
 1.37A 3nyaA-5elgA:
undetectable		 3nyaA-5elgA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eoc FAB FRAGMENT (HEAVY
CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 167
VAL H 185
SER H 183
ASN H 200
ASN H 159
 None
 1.43A 3nyaA-5eocH:
undetectable		 3nyaA-5eocH:
16.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
ASP B 121
VAL B 122
SER B 215
PHE B 306
PHE B 307
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.28A 3nyaA-5f8uB:
39.4		 3nyaA-5f8uB:
41.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 8 TRP B 117
THR B 118
ASP B 121
VAL B 122
SER B 211
PHE B 307
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 (-2.7A)
P32  B 400 (-4.9A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 1.21A 3nyaA-5f8uB:
39.4		 3nyaA-5f8uB:
41.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5f8u BETA-1 ADRENERGIC
RECEPTOR

(Meleagris
gallopavo) 		no annotation 12 TRP B 117
THR B 118
ASP B 121
VAL B 122
VAL B 125
SER B 211
SER B 215
PHE B 306
PHE B 307
ASN B 310
ASN B 329
TYR B 333
 P32  B 400 (-4.8A)
P32  B 400 (-3.8A)
P32  B 400 (-2.2A)
P32  B 400 (-3.5A)
P32  B 400 ( 4.7A)
P32  B 400 (-2.7A)
P32  B 400 ( 4.2A)
P32  B 400 (-4.1A)
P32  B 400 (-4.9A)
P32  B 400 (-3.5A)
P32  B 400 (-2.9A)
P32  B 400 (-4.6A)
 0.53A 3nyaA-5f8uB:
39.4		 3nyaA-5f8uB:
41.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h05 AMYP

(marine
metagenome) 		PF00128
(Alpha-amylase) 		5 TRP A  64
THR A  66
ASP A 124
VAL A 126
SER A  71
 None
 1.38A 3nyaA-5h05A:
undetectable		 3nyaA-5h05A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1q INNEXIN-6

(Caenorhabditis
elegans) 		PF00876
(Innexin) 		5 THR A 268
VAL A 266
VAL A 246
ASN A  73
TYR A 105
 None
 1.42A 3nyaA-5h1qA:
3.0		 3nyaA-5h1qA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i8e VRC34.01 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL A 163
VAL A 182
SER A 180
ASN A 197
ASN A 155
 None
 1.42A 3nyaA-5i8eA:
undetectable		 3nyaA-5i8eA:
17.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihu BOVINE FAB B11 HEAVY
CHAIN

(Bos taurus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 218
VAL H 237
SER H 235
ASN H 251
ASN H 210
 None
 1.43A 3nyaA-5ihuH:
undetectable		 3nyaA-5ihuH:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0q MAB 8C7 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL C 170
VAL C 188
SER C 186
ASN C 203
ASN C 162
 None
 1.43A 3nyaA-5l0qC:
undetectable		 3nyaA-5l0qC:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nph HEAVY CHAIN OF FAB
FRAGMENT DERIVED
FROM
NON-NEUTRALIZING
ANTIBODY DAO5

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL H 170
VAL H 188
SER H 186
ASN H 203
ASN H 162
 None
 1.43A 3nyaA-5nphH:
undetectable		 3nyaA-5nphH:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nst HEAVY CHAIN OF
ANTIBODY MGD21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set)
PF13895
(Ig_2) 		5 VAL B 300
VAL B 318
SER B 316
ASN B 333
ASN B 292
 None
 1.41A 3nyaA-5nstB:
undetectable		 3nyaA-5nstB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t3s FAB 35022 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 163
VAL D 182
SER D 180
ASN D 197
ASN D 155
 None
 1.40A 3nyaA-5t3sD:
undetectable		 3nyaA-5t3sD:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tdg FUSION GLYCOPROTEIN
F0,FIBRITIN

(Bovine
orthopneumovirus;
Enterobacteria
phage T4 sensu
lato) 		PF00523
(Fusion_gly)
PF07921
(Fibritin_C) 		5 THR A 189
VAL A  56
VAL A 300
ASN A 183
TYR A  53
 None
 1.26A 3nyaA-5tdgA:
undetectable		 3nyaA-5tdgA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 0.67A 3nyaA-5v54A:
27.9		 3nyaA-5v54A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Homo sapiens;
Spodoptera
frugiperda) 		no annotation 6 TRP A 125
ASP A 129
SER A 212
PHE A 330
PHE A 331
TYR A 359
 None
89F  A1201 (-3.3A)
89F  A1201 ( 3.8A)
89F  A1201 (-4.1A)
89F  A1201 (-4.6A)
None
 1.00A 3nyaA-5v54A:
27.9		 3nyaA-5v54A:
11.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6l HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A37

(Oryctolagus
cuniculus) 		no annotation 5 VAL H 163
VAL H 182
SER H 180
ASN H 194
ASN H 155
 None
 1.38A 3nyaA-5v6lH:
undetectable		 3nyaA-5v6lH:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5x 3C10 FAB' HEAVY
CHAIN

(Rattus
norvegicus) 		no annotation 5 VAL H 168
VAL H 186
SER H 184
ASN H 201
ASN H 160
 None
None
None
None
EDO  H 303 ( 4.1A)
 1.42A 3nyaA-5w5xH:
undetectable		 3nyaA-5w5xH:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w6g 6649 ANTIBODY HEAVY
CHAIN

(Homo sapiens) 		no annotation 5 VAL H 175
VAL H 194
SER H 192
ASN H 209
ASN H 167
 None
 1.42A 3nyaA-5w6gH:
undetectable		 3nyaA-5w6gH:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 6 ASP A 115
VAL A 116
SER A 196
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 1.15A 3nyaA-5wivA:
30.1		 3nyaA-5wivA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wiv D(4) DOPAMINE
RECEPTOR, SOLUBLE
CYTOCHROME B562
CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 7 ASP A 115
VAL A 116
SER A 196
SER A 200
PHE A 410
PHE A 411
TYR A 438
 AQD  A1201 (-3.3A)
AQD  A1201 ( 3.9A)
AQD  A1201 (-2.8A)
AQD  A1201 (-3.6A)
AQD  A1201 (-4.7A)
AQD  A1201 (-4.6A)
None
 0.84A 3nyaA-5wivA:
30.1		 3nyaA-5wivA:
27.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bpc MONOCLONAL ANTIBODY
4F7 FAB LIGHT CHAIN

(Mus musculus) 		no annotation 5 ASP C  41
VAL C  39
VAL C 102
SER C 194
SER C 104
 None
 1.33A 3nyaA-6bpcC:
undetectable		 3nyaA-6bpcC:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
None
 1.17A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 5 TRP A 130
ASP A 134
SER A 219
PHE A 328
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
E2J  A1201 (-4.4A)
None
 1.15A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 TRP A 130
ASP A 134
VAL A 135
PHE A 327
PHE A 328
ASN A 331
TYR A 358
 None
E2J  A1201 (-3.0A)
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
E2J  A1201 (-4.4A)
None
None
 0.63A 3nyaA-6bqhA:
30.8		 3nyaA-6bqhA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 THR B 160
VAL B 163
VAL B 182
SER B 180
ASN B 194
 None
 1.34A 3nyaA-6cjkB:
undetectable		 3nyaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cjk -

(-) 		no annotation 5 VAL B 163
VAL B 182
SER B 180
ASN B 194
ASN B 155
 None
 1.41A 3nyaA-6cjkB:
undetectable		 3nyaA-6cjkB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ASP A 114
VAL A 115
PHE A 389
PHE A 390
TYR A 416
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
8NU  A2001 ( 4.9A)
 0.49A 3nyaA-6cm4A:
35.3		 3nyaA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cm4 D(2) DOPAMINE
RECEPTOR, ENDOLYSIN
CHIMERA

(Escherichia
virus T4;
Homo sapiens) 		no annotation 5 ASP A 114
VAL A 115
SER A 197
PHE A 389
PHE A 390
 8NU  A2001 ( 3.0A)
8NU  A2001 ( 3.5A)
8NU  A2001 ( 3.6A)
8NU  A2001 ( 4.5A)
8NU  A2001 ( 4.8A)
 0.84A 3nyaA-6cm4A:
35.3		 3nyaA-6cm4A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 0.64A 3nyaA-6g79S:
27.8		 3nyaA-6g79S:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g79 5-HYDROXYTRYPTAMINE
RECEPTOR 1B

(Homo sapiens) 		no annotation 6 TRP S 125
ASP S 129
SER S 212
PHE S 330
PHE S 331
TYR S 359
 None
EP5  S 401 (-3.3A)
EP5  S 401 (-3.3A)
EP5  S 401 (-4.0A)
EP5  S 401 (-4.7A)
EP5  S 401 ( 4.9A)
 1.00A 3nyaA-6g79S:
27.8		 3nyaA-6g79S:
9.93