SIMILAR PATTERNS OF AMINO ACIDS FOR 3NY4_A_SMXA310_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ajz DIHYDROPTEROATE
SYNTHASE

(Escherichia
coli) 		PF00809
(Pterin_bind) 		4 LEU A 204
ALA A 241
GLY A 187
PRO A 186
 None
 0.94A 3ny4A-1ajzA:
undetectable		 3ny4A-1ajzA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bsg BETA LACTAMASE

(Streptomyces
albus) 		PF13354
(Beta-lactamase2) 		5 LEU A 195
ARG A 204
THR A 208
TRP A 251
PRO A 258
 None
 0.54A 3ny4A-1bsgA:
41.0		 3ny4A-1bsgA:
45.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehk BA3-TYPE
CYTOCHROME-C OXIDASE

(Thermus
thermophilus) 		PF00115
(COX1) 		4 LEU A 251
ALA A 318
GLY A 352
PRO A 349
 None
 0.78A 3ny4A-1ehkA:
1.4		 3ny4A-1ehkA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		4 ARG A 255
ALA A 249
THR A 248
GLY A 187
 None
 0.95A 3ny4A-1evqA:
undetectable		 3ny4A-1evqA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f2h TUMOR NECROSIS
FACTOR RECEPTOR TYPE
1 ASSOCIATED DEATH
DOMAIN PROTEIN

(Homo sapiens) 		PF09034
(TRADD_N) 		4 ARG A  43
ALA A  40
GLY A  54
PRO A  56
 None
 0.90A 3ny4A-1f2hA:
undetectable		 3ny4A-1f2hA:
20.15
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1i2w BETA-LACTAMASE

(Bacillus
licheniformis) 		PF13354
(Beta-lactamase2) 		4 LEU A 195
ARG A 204
TRP A 251
PRO A 258
 None
 0.69A 3ny4A-1i2wA:
41.0		 3ny4A-1i2wA:
44.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k5c ENDOPOLYGALACTURONAS
E

(Chondrostereum
purpureum) 		PF00295
(Glyco_hydro_28) 		4 LEU A 257
ALA A 319
THR A 294
GLY A 267
 None
None
None
GOL  A1001 ( 3.8A)
 0.92A 3ny4A-1k5cA:
undetectable		 3ny4A-1k5cA:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7h ALKALINE PHOSPHATASE

(Pandalus
borealis) 		PF00245
(Alk_phosphatase) 		4 LEU A 273
ARG A 279
ALA A 281
GLY A 266
 None
 0.84A 3ny4A-1k7hA:
undetectable		 3ny4A-1k7hA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1li7 CYSTEINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF01406
(tRNA-synt_1e)
PF09190
(DALR_2) 		4 LEU A 391
ARG A  52
ALA A  51
GLY A 296
 None
 0.87A 3ny4A-1li7A:
undetectable		 3ny4A-1li7A:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnq POTASSIUM CHANNEL
RELATED PROTEIN

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N)
PF07885
(Ion_trans_2) 		4 LEU A 185
THR A 127
GLY A 162
PRO A 164
 None
 0.71A 3ny4A-1lnqA:
undetectable		 3ny4A-1lnqA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqt FPRA

(Mycobacterium
tuberculosis) 		PF07992
(Pyr_redox_2) 		4 LEU A 450
ALA A 428
GLY A  80
PRO A  43
 None
 0.89A 3ny4A-1lqtA:
undetectable		 3ny4A-1lqtA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m7s CATALASE

(Pseudomonas
syringae) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 LEU A 263
ARG A  80
ALA A  79
GLY A 206
PRO A 208
 None
 1.19A 3ny4A-1m7sA:
undetectable		 3ny4A-1m7sA:
20.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		4 LEU A 195
ARG A 204
GLY A 256
PRO A 258
 None
 0.82A 3ny4A-1n4oA:
37.2		 3ny4A-1n4oA:
42.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n4o L2 BETA-LACTAMASE

(Stenotrophomonas
maltophilia) 		PF13354
(Beta-lactamase2) 		4 LEU A 195
ARG A 204
TRP A 251
PRO A 258
 None
 0.75A 3ny4A-1n4oA:
37.2		 3ny4A-1n4oA:
42.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pby QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
40 KDA SUBUNIT
QUINOHEMOPROTEIN
AMINE DEHYDROGENASE
60 KDA SUBUNIT

(Paracoccus
denitrificans) 		PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII)
no annotation 		4 LEU B  84
ALA B 133
GLY A 128
PRO A 131
 None
 0.86A 3ny4A-1pbyB:
undetectable		 3ny4A-1pbyB:
25.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgw BEAN POD MOTTLE
VIRUS LARGE (L)
SUBUNIT

(Bean pod mottle
virus) 		PF02247
(Como_LCP) 		4 LEU 2  88
THR 2  36
GLY 2  79
PRO 2 117
 None
 0.95A 3ny4A-1pgw2:
undetectable		 3ny4A-1pgw2:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 LEU A  71
ARG A  72
ALA A  62
GLY A  13
 None
 0.92A 3ny4A-1r2jA:
undetectable		 3ny4A-1r2jA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sa3 TYPE II RESTRICTION
ENZYME MSPI

(Moraxella sp.) 		PF09208
(Endonuc-MspI) 		4 LEU A 199
ALA A 100
THR A  85
GLY A  94
 None
 0.95A 3ny4A-1sa3A:
undetectable		 3ny4A-1sa3A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1si8 CATALASE

(Enterococcus
faecalis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 ALA A  96
THR A  94
GLY A 234
PRO A 237
 None
 0.83A 3ny4A-1si8A:
undetectable		 3ny4A-1si8A:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 LEU A 144
ALA A 403
GLY A 414
PRO A 416
 None
 0.94A 3ny4A-1t34A:
undetectable		 3ny4A-1t34A:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uz4 MAN5A

(Cellvibrio
mixtus) 		PF00150
(Cellulase) 		4 ALA A  83
TRP A  47
GLY A 399
PRO A 401
 None
None
None
IFL  A1432 (-4.6A)
 0.92A 3ny4A-1uz4A:
undetectable		 3ny4A-1uz4A:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9a UROPORPHYRIN-III
C-METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00590
(TP_methylase) 		4 LEU A 172
ALA A 199
THR A 183
GLY A 137
 None
 0.69A 3ny4A-1v9aA:
undetectable		 3ny4A-1v9aA:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9w PUTATIVE 42-9-9
PROTEIN

(Mus musculus) 		PF06110
(DUF953) 		4 LEU A  95
ALA A  99
THR A 102
GLY A  18
 None
 0.91A 3ny4A-1v9wA:
undetectable		 3ny4A-1v9wA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ve5 THREONINE DEAMINASE

(Thermus
thermophilus) 		PF00291
(PALP) 		5 LEU A 182
ARG A  53
ALA A  52
GLY A 280
PRO A 176
 PLP  A 413 (-4.5A)
None
None
None
PLP  A 413 (-4.4A)
 1.47A 3ny4A-1ve5A:
undetectable		 3ny4A-1ve5A:
24.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vft ALANINE RACEMASE

(Streptomyces
lavendulae) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 LEU A 222
ALA A 211
THR A 212
GLY A  62
 None
 0.92A 3ny4A-1vftA:
undetectable		 3ny4A-1vftA:
25.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vl8 GLUCONATE
5-DEHYDROGENASE

(Thermotoga
maritima) 		PF13561
(adh_short_C2) 		4 LEU A 226
ALA A 234
GLY A 145
PRO A 190
 None
None
None
NAP  A 274 (-3.8A)
 0.86A 3ny4A-1vl8A:
undetectable		 3ny4A-1vl8A:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wck BCLA PROTEIN

(Bacillus
anthracis) 		PF01391
(Collagen) 		4 LEU A 151
ALA A 172
THR A 142
GLY A 195
 None
 0.90A 3ny4A-1wckA:
undetectable		 3ny4A-1wckA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 ALA A  98
THR A  11
GLY A 333
PRO A 331
 None
 0.92A 3ny4A-1wdtA:
undetectable		 3ny4A-1wdtA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x1q TRYPTOPHAN SYNTHASE
BETA CHAIN

(Thermus
thermophilus) 		PF00291
(PALP) 		4 LEU A 210
ALA A 191
THR A 192
GLY A 255
 None
 0.92A 3ny4A-1x1qA:
undetectable		 3ny4A-1x1qA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 LEU A 477
ALA A  23
THR A  26
GLY A 264
 None
 0.90A 3ny4A-1xrsA:
undetectable		 3ny4A-1xrsA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yqd SINAPYL ALCOHOL
DEHYDROGENASE

(Populus
tremuloides) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 333
ALA A 359
THR A 360
GLY A 137
 None
 0.94A 3ny4A-1yqdA:
undetectable		 3ny4A-1yqdA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		4 LEU A 323
ARG A 204
ALA A 203
GLY A 250
 None
 0.92A 3ny4A-1z8lA:
undetectable		 3ny4A-1z8lA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zel HYPOTHETICAL PROTEIN
RV2827C

(Mycobacterium
tuberculosis) 		PF09407
(AbiEi_1)
PF13338
(AbiEi_4) 		5 LEU A 284
ARG A 230
ALA A 231
TRP A 197
GLY A 195
 None
 1.28A 3ny4A-1zelA:
undetectable		 3ny4A-1zelA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ae0 MEMBRANE-BOUND LYTIC
MUREIN
TRANSGLYCOSYLASE A

(Escherichia
coli) 		PF03562
(MltA)
PF06725
(3D) 		4 LEU X 290
ARG X 291
ALA X 256
GLY X  72
 None
 0.77A 3ny4A-2ae0X:
undetectable		 3ny4A-2ae0X:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 LEU A 344
ARG A 348
ALA A 351
GLY A  83
PRO A  85
 None
 1.31A 3ny4A-2bbvA:
undetectable		 3ny4A-2bbvA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2coe DEOXYNUCLEOTIDYLTRAN
SFERASE, TERMINAL
VARIANT

(Homo sapiens) 		PF00533
(BRCT) 		4 LEU A  24
ARG A  51
GLY A 103
PRO A 105
 None
 0.85A 3ny4A-2coeA:
undetectable		 3ny4A-2coeA:
18.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw5 BACTERIAL
FLUORINATING ENZYME
HOMOLOG

(Thermus
thermophilus) 		PF01887
(SAM_adeno_trans) 		4 LEU A 254
ARG A 253
GLY A 197
PRO A 195
 None
 0.95A 3ny4A-2cw5A:
undetectable		 3ny4A-2cw5A:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dou PROBABLE
N-SUCCINYLDIAMINOPIM
ELATE
AMINOTRANSFERASE

(Thermus
thermophilus) 		PF00155
(Aminotran_1_2) 		4 LEU A 375
ARG A 335
GLY A 322
PRO A 320
 None
 0.91A 3ny4A-2douA:
undetectable		 3ny4A-2douA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		4 LEU A 137
ALA A 140
THR A 151
GLY A 190
 None
 0.88A 3ny4A-2ewyA:
undetectable		 3ny4A-2ewyA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f2a ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B

(Staphylococcus
aureus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N) 		4 LEU B 369
ALA B 395
THR B 362
GLY B 346
 None
 0.93A 3ny4A-2f2aB:
undetectable		 3ny4A-2f2aB:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		4 LEU A  35
ARG A  67
ALA A  66
GLY A   8
 None
 0.91A 3ny4A-2f9tA:
undetectable		 3ny4A-2f9tA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g9h EXTRACELLULAR
ENTEROTOXIN TYPE I

(Staphylococcus
aureus) 		PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C) 		4 LEU D   9
ARG D  10
THR D  14
GLY D 164
 None
 0.82A 3ny4A-2g9hD:
undetectable		 3ny4A-2g9hD:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0s AROMATIC AMINE
DEHYDROGENASE

(Alcaligenes
faecalis) 		PF06433
(Me-amine-dh_H) 		5 LEU A 313
ARG A 370
ALA A 372
GLY A 326
PRO A 325
 None
 1.30A 3ny4A-2i0sA:
undetectable		 3ny4A-2i0sA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7p PANTOTHENATE KINASE
3

(Homo sapiens) 		PF03630
(Fumble) 		4 LEU A 139
ALA A 362
THR A 114
GLY A 321
 None
 0.92A 3ny4A-2i7pA:
undetectable		 3ny4A-2i7pA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 625
ALA A 646
GLY A 185
PRO A 600
 None
 0.87A 3ny4A-2ivfA:
undetectable		 3ny4A-2ivfA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 386
ALA A 349
GLY A  72
PRO A  54
 None
 0.89A 3ny4A-2iwzA:
undetectable		 3ny4A-2iwzA:
21.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 390
ALA A 351
GLY A  61
PRO A  43
 None
 0.87A 3ny4A-2ix4A:
undetectable		 3ny4A-2ix4A:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jf4 PERIPLASMIC
TREHALASE

(Escherichia
coli) 		PF01204
(Trehalase) 		5 LEU A 456
ALA A 449
THR A 439
TRP A 311
GLY A 310
 None
None
None
None
VDM  A1548 (-3.7A)
 1.10A 3ny4A-2jf4A:
undetectable		 3ny4A-2jf4A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 LEU A 423
ALA A 449
THR A 451
GLY A 135
 None
MGD  A 811 ( 3.8A)
None
None
 0.87A 3ny4A-2jirA:
undetectable		 3ny4A-2jirA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8d LAMIN-B RECEPTOR

(Gallus gallus) 		PF09465
(LBR_tudor) 		4 LEU A  51
TRP A  20
GLY A  22
PRO A  21
 None
 0.91A 3ny4A-2l8dA:
undetectable		 3ny4A-2l8dA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nr5 HYPOTHETICAL PROTEIN
SO2669

(Shewanella
oneidensis) 		no annotation 4 LEU A  57
ARG A  12
ALA A   9
GLY A  20
 None
 0.69A 3ny4A-2nr5A:
undetectable		 3ny4A-2nr5A:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ntt STAPHYLOCOCCAL
ENTEROTOXIN K

(Staphylococcus
aureus) 		PF02876
(Stap_Strp_tox_C) 		4 LEU A   9
ARG A  10
THR A  14
GLY A 164
 None
None
EDO  A7010 ( 4.9A)
EDO  A7009 (-4.7A)
 0.90A 3ny4A-2nttA:
undetectable		 3ny4A-2nttA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pgs PUTATIVE
DEOXYGUANOSINETRIPHO
SPHATE
TRIPHOSPHOHYDROLASE

(Pseudomonas
savastanoi) 		PF01966
(HD) 		4 LEU A   9
ARG A  11
THR A 176
GLY A  78
 None
 0.93A 3ny4A-2pgsA:
undetectable		 3ny4A-2pgsA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v26 MYOSIN VI

(Sus scrofa) 		PF00063
(Myosin_head) 		4 LEU A 386
ARG A 387
THR A 391
GLY A 348
 None
 0.91A 3ny4A-2v26A:
undetectable		 3ny4A-2v26A:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v6j RNA HELICASE

(Kokobera virus) 		PF00271
(Helicase_C)
PF07652
(Flavi_DEAD) 		4 LEU A 105
ALA A 111
TRP A 301
GLY A 297
 None
 0.90A 3ny4A-2v6jA:
undetectable		 3ny4A-2v6jA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wfc PEROXIREDOXIN 5

(Arenicola
marina) 		PF08534
(Redoxin) 		4 LEU A 141
ALA A  69
THR A  71
GLY A 171
 None
 0.95A 3ny4A-2wfcA:
undetectable		 3ny4A-2wfcA:
21.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2wyx BETA-LACTAMSE TOHO-1

(Escherichia
coli) 		PF13354
(Beta-lactamase2) 		4 LEU A 195
ALA A 205
TRP A 251
PRO A 258
 None
 0.91A 3ny4A-2wyxA:
40.1		 3ny4A-2wyxA:
45.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xij METHYLMALONYL-COA
MUTASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01642
(MM_CoA_mutase)
PF02310
(B12-binding) 		4 LEU A 394
THR A 499
GLY A 725
PRO A 724
 None
None
B12  A 800 ( 4.4A)
B12  A 800 (-4.0A)
 0.88A 3ny4A-2xijA:
undetectable		 3ny4A-2xijA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0j PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1438

(Thermus
thermophilus) 		PF04029
(2-ph_phosp) 		5 LEU A  48
ALA A 231
THR A  45
GLY A  76
PRO A  70
 None
 1.47A 3ny4A-2z0jA:
undetectable		 3ny4A-2z0jA:
25.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z5l TYLACTONE SYNTHASE
STARTER MODULE AND
MODULES 1 & 2

(Streptomyces
fradiae) 		PF08659
(KR) 		4 LEU A 426
ALA A 465
THR A 468
GLY A 373
 None
 0.83A 3ny4A-2z5lA:
undetectable		 3ny4A-2z5lA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2q 6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE

(Arthrobacter
sp. KI72) 		PF01425
(Amidase) 		4 LEU A 263
ALA A 279
GLY A 269
PRO A 267
 None
None
GOL  A 603 (-3.4A)
None
 0.92A 3ny4A-3a2qA:
undetectable		 3ny4A-3a2qA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abs ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		4 LEU B 182
ALA B 274
GLY B 197
PRO B 199
 None
 0.95A 3ny4A-3absB:
undetectable		 3ny4A-3absB:
25.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agr NUCLEOSIDE
TRIPHOSPHATE
HYDROLASE

(Neospora
caninum) 		PF01150
(GDA1_CD39) 		4 LEU A 182
ARG A 183
THR A 199
GLY A  47
 None
 0.90A 3ny4A-3agrA:
undetectable		 3ny4A-3agrA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE LIGHT
CHAIN

(Escherichia
coli) 		PF05985
(EutC) 		4 LEU B 182
ALA B 274
GLY B 197
PRO B 199
 None
 0.93A 3ny4A-3anyB:
undetectable		 3ny4A-3anyB:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ber PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX47

(Homo sapiens) 		PF00270
(DEAD) 		4 LEU A 115
THR A  75
TRP A  44
GLY A  43
 None
AMP  A 300 (-3.6A)
AMP  A 300 (-3.5A)
None
 0.92A 3ny4A-3berA:
undetectable		 3ny4A-3berA:
22.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3bfg CLASS A
BETA-LACTAMASE SED1

(Citrobacter
sedlakii) 		PF13354
(Beta-lactamase2) 		5 LEU A 195
ARG A 204
ALA A 205
TRP A 251
PRO A 258
 None
 0.81A 3ny4A-3bfgA:
40.5		 3ny4A-3bfgA:
46.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjn TRANSCRIPTIONAL
REGULATOR, PUTATIVE

(Vibrio cholerae) 		PF01614
(IclR) 		4 LEU A 209
ALA A 154
GLY A 184
PRO A 202
 None
 0.93A 3ny4A-3bjnA:
2.7		 3ny4A-3bjnA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxp PUTATIVE
LIPASE/ESTERASE

(Lactobacillus
plantarum) 		PF07859
(Abhydrolase_3) 		4 ALA A  91
THR A  92
GLY A 118
PRO A  41
 None
 0.94A 3ny4A-3bxpA:
undetectable		 3ny4A-3bxpA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c1x HEPATOCYTE GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 LEU A1125
ALA A1057
GLY A1151
PRO A1153
 None
 0.93A 3ny4A-3c1xA:
undetectable		 3ny4A-3c1xA:
21.76
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3dwz BETA-LACTAMASE

(Mycobacterium
tuberculosis) 		PF13354
(Beta-lactamase2) 		8 LEU A 211
ARG A 220
ALA A 221
THR A 224
LYS A 246
TRP A 266
GLY A 270
PRO A 272
 None
 0.33A 3ny4A-3dwzA:
49.6		 3ny4A-3dwzA:
99.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e60 3-OXOACYL-[ACYL-CARR
IER-PROTEIN ]
SYNTHASE II

(Bartonella
henselae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 348
ALA A 310
GLY A  32
PRO A  14
 None
 0.91A 3ny4A-3e60A:
undetectable		 3ny4A-3e60A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 LEU A 297
ALA A 315
THR A 313
GLY A 259
 None
 0.93A 3ny4A-3gcwA:
undetectable		 3ny4A-3gcwA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hsy GLUTAMATE RECEPTOR 2

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 ALA A 277
THR A 279
GLY A  15
PRO A  13
 None
 0.94A 3ny4A-3hsyA:
undetectable		 3ny4A-3hsyA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ju8 SUCCINYLGLUTAMIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 LEU A  19
ALA A  13
THR A   4
GLY A 206
 None
None
None
NAD  A 501 ( 4.4A)
 0.87A 3ny4A-3ju8A:
undetectable		 3ny4A-3ju8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		4 ALA A 343
TRP A 165
GLY A 169
PRO A 171
 None
 0.95A 3ny4A-3k7tA:
undetectable		 3ny4A-3k7tA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxd CALCIUM-GATED
POTASSIUM CHANNEL
MTHK

(Methanothermobacter
thermautotrophicus) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 LEU A 185
THR A 127
GLY A 162
PRO A 164
 None
 0.72A 3ny4A-3kxdA:
undetectable		 3ny4A-3kxdA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
SYNTHASE II

(Brucella
melitensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 LEU A 348
ALA A 310
GLY A  32
PRO A  14
 None
 0.93A 3ny4A-3kzuA:
undetectable		 3ny4A-3kzuA:
23.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		4 LEU A 208
ARG A 217
THR A 221
TRP A 263
 None
 0.76A 3ny4A-3lezA:
40.2		 3ny4A-3lezA:
44.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		4 LEU A 208
ARG A 217
TRP A 263
PRO A 270
 None
 0.70A 3ny4A-3lezA:
40.2		 3ny4A-3lezA:
44.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ll3 GLUCONATE KINASE

(Lactobacillus
acidophilus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 LEU A 446
ALA A 439
THR A 209
GLY A 244
 None
 0.91A 3ny4A-3ll3A:
undetectable		 3ny4A-3ll3A:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lm6 STAGE V SPORULATION
PROTEIN AD

(Bacillus
subtilis) 		PF07451
(SpoVAD) 		4 LEU A  33
ALA A  23
THR A  22
GLY A 262
 None
 0.95A 3ny4A-3lm6A:
undetectable		 3ny4A-3lm6A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		4 LEU A  33
ALA A  23
THR A  22
GLY A 262
 None
 0.95A 3ny4A-3lmaA:
undetectable		 3ny4A-3lmaA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6c 60 KDA CHAPERONIN 1

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		5 LEU A 213
THR A 204
LYS A 267
GLY A 242
PRO A 244
 None
 1.45A 3ny4A-3m6cA:
undetectable		 3ny4A-3m6cA:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmk FUSION OF
LIM/HOMEOBOX PROTEIN
LHX4, LINKER,
INSULIN GENE
ENHANCER PROTEIN
ISL-2

(Mus musculus) 		PF00412
(LIM) 		4 LEU A 112
ALA A  91
GLY A 278
PRO A 280
 None
ZN  A 867 ( 4.8A)
None
None
 0.89A 3ny4A-3mmkA:
undetectable		 3ny4A-3mmkA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpl VIRULENCE SENSOR
PROTEIN BVGS

(Bordetella
pertussis) 		PF00497
(SBP_bac_3) 		4 LEU A 510
ARG A 343
THR A 344
GLY A 372
 EDO  A   1 (-3.9A)
None
None
None
 0.92A 3ny4A-3mplA:
undetectable		 3ny4A-3mplA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwo PROLINE
IMINOPEPTIDASE

(Mycolicibacterium
smegmatis) 		PF00561
(Abhydrolase_1) 		4 LEU A 229
TRP A 114
GLY A  41
PRO A  43
 GOL  A 311 (-4.4A)
None
EDO  A 312 ( 4.5A)
GOL  A 311 (-4.8A)
 0.89A 3ny4A-3nwoA:
undetectable		 3ny4A-3nwoA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 LEU A  25
ARG A  90
ALA A  69
GLY A  84
 SO4  A 435 (-3.9A)
None
None
None
 0.81A 3ny4A-3nwrA:
undetectable		 3ny4A-3nwrA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3orf DIHYDROPTERIDINE
REDUCTASE

(Dictyostelium
discoideum) 		PF00106
(adh_short) 		4 LEU A 173
ALA A  16
GLY A 124
PRO A 170
 NAD  A 901 (-3.9A)
None
None
NAD  A 901 (-3.9A)
 0.94A 3ny4A-3orfA:
undetectable		 3ny4A-3orfA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3phg SHIKIMATE
DEHYDROGENASE

(Helicobacter
pylori) 		PF08501
(Shikimate_dh_N) 		4 LEU A 184
ALA A 179
GLY A  10
PRO A  12
 None
 0.91A 3ny4A-3phgA:
undetectable		 3ny4A-3phgA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm6 PUTATIVE
FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Coccidioides
immitis) 		PF01116
(F_bP_aldolase) 		4 LEU A  12
THR A  82
TRP A 183
GLY A 219
 None
 0.91A 3ny4A-3pm6A:
undetectable		 3ny4A-3pm6A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppi 3-HYDROXYACYL-COA
DEHYDROGENASE TYPE-2

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		4 LEU A 175
ALA A 194
THR A 192
GLY A 121
 None
 0.95A 3ny4A-3ppiA:
undetectable		 3ny4A-3ppiA:
23.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 LEU A 229
ALA A 215
THR A 244
GLY A 161
 None
 0.87A 3ny4A-3q9cA:
undetectable		 3ny4A-3q9cA:
29.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qat MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Bartonella
henselae) 		PF00698
(Acyl_transf_1) 		4 LEU A 249
ALA A 225
THR A 106
GLY A  92
 None
 0.82A 3ny4A-3qatA:
undetectable		 3ny4A-3qatA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qnw CASPASE-6

(Homo sapiens) 		PF00656
(Peptidase_C14) 		4 LEU B 286
ALA A  34
GLY A 153
PRO A 155
 None
 0.94A 3ny4A-3qnwB:
undetectable		 3ny4A-3qnwB:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qua PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycolicibacterium
smegmatis) 		PF03641
(Lysine_decarbox) 		4 LEU A 147
ALA A  25
THR A 125
GLY A 156
 None
 0.89A 3ny4A-3quaA:
undetectable		 3ny4A-3quaA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sig POLY(ADP-RIBOSE)
GLYCOHYDROLASE

(Thermomonospora
curvata) 		PF10021
(DUF2263) 		4 LEU A  77
ARG A  81
THR A  84
GLY A 122
 None
 0.84A 3ny4A-3sigA:
undetectable		 3ny4A-3sigA:
28.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sjn MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Shewanella
pealeana) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 316
ALA A 351
GLY A 302
PRO A 300
 None
 0.84A 3ny4A-3sjnA:
undetectable		 3ny4A-3sjnA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slk POLYKETIDE SYNTHASE
EXTENDER MODULE 2

(Saccharopolyspora
spinosa) 		PF08240
(ADH_N)
PF08659
(KR)
PF13602
(ADH_zinc_N_2) 		5 ARG A 191
ALA A 278
TRP A 190
GLY A 187
PRO A 185
 None
 0.93A 3ny4A-3slkA:
undetectable		 3ny4A-3slkA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		4 LEU A  47
ARG A  87
ALA A  86
GLY A 187
 None
 0.91A 3ny4A-3t44A:
undetectable		 3ny4A-3t44A:
24.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t44 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Mycobacterium
tuberculosis) 		PF00218
(IGPS) 		4 LEU A  77
ALA A  61
GLY A 249
PRO A 251
 None
 0.94A 3ny4A-3t44A:
undetectable		 3ny4A-3t44A:
24.26