SIMILAR PATTERNS OF AMINO ACIDS FOR 3NXU_B_RITB600_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0c XYLOSE ISOMERASE

(Thermoanaerobacterium
thermosulfurigenes)
PF01261
(AP_endonuc_2)
5 PHE A  97
ILE A 222
PHE A 224
ALA A 219
ALA A 141
None
1.19A 3nxuB-1a0cA:
0.0
3nxuB-1a0cA:
24.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aye PROCARBOXYPEPTIDASE
A2


(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 PHE A  52
MET A  22
THR A  54
ALA A  66
ILE A 193
None
1.09A 3nxuB-1ayeA:
undetectable
3nxuB-1ayeA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b1y PROTEIN
(BETA-AMYLASE)


(Hordeum vulgare)
PF01373
(Glyco_hydro_14)
5 MET A 156
LEU A 290
ILE A 275
ILE A 294
ALA A 295
None
1.18A 3nxuB-1b1yA:
0.0
3nxuB-1b1yA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1


(Escherichia
coli)
PF01228
(Gly_radical)
PF02901
(PFL-like)
5 LEU A 604
THR A 616
ALA A 523
ILE A 588
ALA A 487
None
1.18A 3nxuB-1h17A:
0.0
3nxuB-1h17A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT


(Klebsiella
pneumoniae)
PF02286
(Dehydratase_LU)
5 THR A 263
ILE A  72
ALA A 108
ILE A  88
ALA A  85
None
1.02A 3nxuB-1iwpA:
0.0
3nxuB-1iwpA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I


(Rattus
norvegicus)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
5 PHE A  80
SER A 267
THR A  97
ILE A 281
ALA A 286
None
1.19A 3nxuB-1jqpA:
0.0
3nxuB-1jqpA:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3b DIPEPTYDIL-PEPTIDASE
I EXCLUSION DOMAIN
DIPEPTYDIL-PEPTIDASE
I LIGHT CHAIN


(Homo sapiens)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
5 PHE A  80
SER B 268
THR A  97
ILE B 282
ALA B 287
None
1.15A 3nxuB-1k3bA:
undetectable
3nxuB-1k3bA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE


(Homo sapiens)
PF13180
(PDZ_2)
PF13365
(Trypsin_2)
5 MET A 127
LEU A 110
PHE A 208
ILE A 101
ALA A  85
None
1.09A 3nxuB-1lcyA:
undetectable
3nxuB-1lcyA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pca PROCARBOXYPEPTIDASE
A PCPA


(Sus scrofa)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 PHE A  52
MET A  22
THR A  54
ILE A 109
ILE A 193
None
1.09A 3nxuB-1pcaA:
undetectable
3nxuB-1pcaA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tff UBIQUITIN
THIOLESTERASE
PROTEIN OTUB2


(Homo sapiens)
PF10275
(Peptidase_C65)
5 PHE A 102
LEU A  64
PHE A  74
ILE A 189
ILE A 227
None
1.14A 3nxuB-1tffA:
undetectable
3nxuB-1tffA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria))
PF01270
(Glyco_hydro_8)
5 MET A 214
SER A 191
ILE A 188
ILE A 144
ALA A 141
None
1.16A 3nxuB-1v5cA:
undetectable
3nxuB-1v5cA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE


(Vibrio
proteolyticus)
PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36)
5 PHE A 448
MET A 440
PHE A 730
ALA A 511
ALA A 468
None
0.90A 3nxuB-1v7vA:
undetectable
3nxuB-1v7vA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w74 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
A


(Mycobacterium
tuberculosis)
PF00160
(Pro_isomerase)
5 PHE A 127
PHE A 107
PHE A  71
ILE A 148
ALA A  29
None
1.20A 3nxuB-1w74A:
undetectable
3nxuB-1w74A:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x8v CYTOCHROME P450 51

(Mycobacterium
tuberculosis)
PF00067
(p450)
5 MET A 433
PHE A  78
ILE A 323
ALA A 346
ALA A 389
ESL  A 471 (-4.7A)
ESL  A 471 ( 4.9A)
None
None
None
1.14A 3nxuB-1x8vA:
34.5
3nxuB-1x8vA:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avt DNA POLYMERASE III
BETA SUBUNIT


(Streptococcus
pyogenes)
PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3)
5 PHE A  11
LEU A  77
PHE A  82
ILE A   2
ALA A  74
None
1.12A 3nxuB-2avtA:
undetectable
3nxuB-2avtA:
23.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2boa CARBOXYPEPTIDASE A4

(Homo sapiens)
PF00246
(Peptidase_M14)
PF02244
(Propep_M14)
5 PHE A1052
MET A1022
THR A1054
ALA A1066
ILE A1193
None
1.10A 3nxuB-2boaA:
undetectable
3nxuB-2boaA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbn RIBONUCLEASE Z

(Escherichia
coli)
PF12706
(Lactamase_B_2)
5 LEU A  89
THR A  20
ILE A 118
ILE A 126
ALA A 136
None
1.18A 3nxuB-2cbnA:
undetectable
3nxuB-2cbnA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5i AZO REDUCTASE

(Escherichia
coli)
PF02525
(Flavodoxin_2)
5 LEU A   4
ILE A  91
ALA A 134
ILE A 197
ALA A 193
None
1.20A 3nxuB-2d5iA:
undetectable
3nxuB-2d5iA:
18.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkh 3-HYDROXYBENZOATE
HYDROXYLASE


(Comamonas
testosteroni)
PF01494
(FAD_binding_3)
PF07976
(Phe_hydrox_dim)
5 PHE A 370
PHE A  90
ALA A  91
ILE A  77
ALA A  78
None
1.10A 3nxuB-2dkhA:
undetectable
3nxuB-2dkhA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE


(Thermus
thermophilus)
PF00464
(SHMT)
5 PHE A 314
MET A 374
THR A 306
ILE A 364
ALA A 363
None
1.08A 3nxuB-2dkjA:
undetectable
3nxuB-2dkjA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e9q 11S GLOBULIN SUBUNIT
BETA


(Cucurbita
maxima)
PF00190
(Cupin_1)
5 SER A  81
LEU A 322
PHE A 131
ILE A 100
ALA A  99
None
0.94A 3nxuB-2e9qA:
undetectable
3nxuB-2e9qA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL


(Rattus
norvegicus)
PF00755
(Carn_acyltransf)
5 LEU A 587
PHE A 134
PHE A 471
ALA A 470
ILE A 621
None
1.08A 3nxuB-2h4tA:
undetectable
3nxuB-2h4tA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ho5 OXIDOREDUCTASE,
GFO/IDH/MOCA FAMILY


(Streptococcus
pneumoniae)
PF01408
(GFO_IDH_MocA)
5 PHE A  63
LEU A  55
PHE A  58
ILE A  68
ALA A  79
None
1.14A 3nxuB-2ho5A:
undetectable
3nxuB-2ho5A:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iwz 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE


(Homo sapiens)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 THR A 383
PHE A 267
ILE A 363
ALA A 362
ALA A 452
None
1.09A 3nxuB-2iwzA:
undetectable
3nxuB-2iwzA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lgh UNCHARACTERIZED
PROTEIN


(Aeromonas
hydrophila)
PF08327
(AHSA1)
5 PHE A  81
THR A  71
ILE A 124
ILE A   3
ALA A 108
None
1.16A 3nxuB-2lghA:
undetectable
3nxuB-2lghA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mf4 HYBRID POLYKETIDE
SYNTHASE-NON
RIBOSOMAL PEPTIDE
SYNTHETASE


(Streptomyces
virginiae)
PF00550
(PP-binding)
5 PHE A6763
LEU A6745
THR A6765
PHE A6776
ILE A6806
None
1.01A 3nxuB-2mf4A:
undetectable
3nxuB-2mf4A:
11.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pg8 DPGC

(Streptomyces
toyocaensis)
PF00378
(ECH_1)
5 PHE A 412
ILE A 324
ALA A 319
ILE A 294
ALA A 233
None
OXY  A   3 (-3.9A)
OXY  A   3 (-3.2A)
YE1  A 997 ( 4.4A)
YE1  A 997 (-3.9A)
0.92A 3nxuB-2pg8A:
undetectable
3nxuB-2pg8A:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qv5 UNCHARACTERIZED
PROTEIN ATU2773


(Agrobacterium
fabrum)
PF04748
(Polysacc_deac_2)
5 SER A 376
LEU A 204
ILE A 372
ALA A 362
ALA A 358
None
1.15A 3nxuB-2qv5A:
undetectable
3nxuB-2qv5A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qyg RIBULOSE
BISPHOSPHATE
CARBOXYLASE-LIKE
PROTEIN 2


(Rhodopseudomonas
palustris)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 PHE A 316
THR A 308
ILE A 239
ALA A 237
ILE A 196
None
1.12A 3nxuB-2qygA:
undetectable
3nxuB-2qygA:
22.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
5 LEU A 177
PHE A 109
PHE A 187
ILE A 133
ALA A 132
None
1.18A 3nxuB-2vn7A:
undetectable
3nxuB-2vn7A:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wpg AMYLOSUCRASE OR
ALPHA AMYLASE


(Xanthomonas
campestris)
PF00128
(Alpha-amylase)
PF11941
(DUF3459)
6 PHE A 278
LEU A  75
PHE A  87
ALA A  68
ILE A 313
ALA A 309
None
1.45A 3nxuB-2wpgA:
undetectable
3nxuB-2wpgA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N


(Thermosynechococcus
elongatus)
PF00148
(Oxidored_nitro)
5 PHE A 251
LEU A 205
THR A 149
ILE A 426
ALA A 424
None
1.12A 3nxuB-2xdqA:
undetectable
3nxuB-2xdqA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yij PHOSPHOLIPASE
A1-IIGAMMA


(Arabidopsis
thaliana)
PF01764
(Lipase_3)
5 PHE A 282
THR A 247
PHE A 113
ILE A 304
ALA A 273
None
1.15A 3nxuB-2yijA:
undetectable
3nxuB-2yijA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aag GENERAL
GLYCOSYLATION
PATHWAY PROTEIN


(Campylobacter
jejuni)
PF02516
(STT3)
5 PHE A 550
MET A 529
LEU A 542
PHE A 541
ALA A 490
MLY  A 551 ( 4.1A)
None
None
None
None
1.00A 3nxuB-3aagA:
undetectable
3nxuB-3aagA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3akk CTKA

(Helicobacter
pylori)
PF07804
(HipA_C)
5 PHE A 145
PHE A 140
ILE A 282
ILE A  63
ALA A  60
None
1.03A 3nxuB-3akkA:
undetectable
3nxuB-3akkA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4a PROBABLE TRYPTOPHAN
HYDROXYLASE VIOD


(Chromobacterium
violaceum)
no annotation 5 LEU A  77
PHE A 345
ILE A 188
ILE A 278
ALA A 324
None
1.11A 3nxuB-3c4aA:
undetectable
3nxuB-3c4aA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cze SUCROSE HYDROLASE

(Xanthomonas
citri)
PF00128
(Alpha-amylase)
5 PHE A 277
LEU A  74
ALA A  67
ILE A 312
ALA A 308
None
1.19A 3nxuB-3czeA:
undetectable
3nxuB-3czeA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d1n POU DOMAIN, CLASS 6,
TRANSCRIPTION FACTOR
1


(Homo sapiens)
PF00046
(Homeobox)
PF00157
(Pou)
5 ILE I 147
PHE I 150
ALA I 151
ILE I 185
ALA I 184
None
1.11A 3nxuB-3d1nI:
undetectable
3nxuB-3d1nI:
14.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3git CARBON MONOXIDE
DEHYDROGENASE/ACETYL
-COA SYNTHASE
SUBUNIT ALPHA


(Moorella
thermoacetica)
PF03598
(CdhC)
5 SER A 594
PHE A 677
PHE A 628
ILE A 635
ILE A 658
None
1.04A 3nxuB-3gitA:
undetectable
3nxuB-3gitA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l3f PROTEIN DOA1

(Saccharomyces
cerevisiae)
PF08324
(PUL)
PF09070
(PFU)
5 LEU X 576
THR X 634
ILE X 603
ILE X 620
ALA X 666
None
1.18A 3nxuB-3l3fX:
undetectable
3nxuB-3l3fX:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA


(Escherichia
coli)
PF00873
(ACR_tran)
5 LEU A 474
PHE A 378
THR A  34
ILE A 565
ILE A 998
None
1.19A 3nxuB-3ne5A:
2.5
3nxuB-3ne5A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdf DIPEPTIDYL PEPTIDASE
1


(Homo sapiens)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
5 PHE A  80
SER A 268
THR A  97
ILE A 282
ALA A 287
None
1.18A 3nxuB-3pdfA:
undetectable
3nxuB-3pdfA:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6c PUTATIVE MAND FAMILY
DEHYDRATASE


(Pantoea
ananatis)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 THR A 128
ILE A 228
ALA A 233
ILE A 271
ALA A 272
None
1.12A 3nxuB-3t6cA:
undetectable
3nxuB-3t6cA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vzi CRISPR-ASSOCIATED
PROTEIN CAS5, DVULG
SUBTYPE


(Xanthomonas
oryzae)
PF09704
(Cas_Cas5d)
5 PHE A 120
THR A 123
ALA A 143
ILE A  39
ALA A  36
None
1.15A 3nxuB-3vziA:
undetectable
3nxuB-3vziA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c41 CORTICOSTEROID-BINDI
NG GLOBULIN


(Homo sapiens)
PF00079
(Serpin)
5 PHE A 366
PHE A  94
THR A 370
PHE A  26
ILE A 362
None
1.17A 3nxuB-4c41A:
undetectable
3nxuB-4c41A:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c4a PROTEIN ARGININE
N-METHYLTRANSFERASE
7


(Mus musculus)
PF06325
(PrmA)
5 PHE A 112
LEU A  77
PHE A 540
ILE A 140
ALA A  66
None
SAH  A1689 ( 4.5A)
None
None
None
1.18A 3nxuB-4c4aA:
undetectable
3nxuB-4c4aA:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2t SSFS6

(Streptomyces
sp. SF2575)
PF00201
(UDPGT)
PF06722
(DUF1205)
5 LEU A 169
ILE A 130
ALA A 125
ILE A   6
ALA A  34
None
1.12A 3nxuB-4g2tA:
undetectable
3nxuB-4g2tA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl8 OLIGOPEPTIDE ABC
TRANSPORTER OPPAIV


(Borreliella
burgdorferi)
PF00496
(SBP_bac_5)
5 MET A 177
LEU A 167
PHE A 174
ILE A 133
ALA A 140
None
1.07A 3nxuB-4gl8A:
undetectable
3nxuB-4gl8A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4grh AMINODEOXYCHORISMATE
SYNTHASE


(Stenotrophomonas
maltophilia)
PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N)
5 LEU A 407
THR A  34
PHE A 393
ALA A 411
ALA A 236
None
1.17A 3nxuB-4grhA:
undetectable
3nxuB-4grhA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 11
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 17
MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22


(Schizosaccharomyces
pombe)
PF06179
(Med22)
PF10156
(Med17)
no annotation
5 SER Q 183
ILE V  56
ALA V  39
ILE K  45
ALA K  44
None
1.16A 3nxuB-4h63Q:
undetectable
3nxuB-4h63Q:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hrt GLOBIN-2 A CHAIN

(Scapharca
inaequivalvis)
PF00042
(Globin)
5 THR A 121
PHE A  97
ALA A  98
ILE A 106
ALA A 110
None
HEM  A 201 (-4.4A)
None
HEM  A 201 (-4.4A)
HEM  A 201 ( 4.8A)
1.13A 3nxuB-4hrtA:
undetectable
3nxuB-4hrtA:
15.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ij4 CHITINASE A

(Gemmabryum
coronatum)
PF00182
(Glyco_hydro_19)
5 SER A  62
PHE A  12
ILE A  58
ALA A 136
ALA A 126
None
1.01A 3nxuB-4ij4A:
undetectable
3nxuB-4ij4A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
5 PHE A 236
LEU A 309
PHE A 164
ALA A 312
ALA A 320
None
1.10A 3nxuB-4js5A:
undetectable
3nxuB-4js5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4js5 EXODEOXYRIBONUCLEASE
I


(Escherichia
coli)
PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C)
5 PHE A 236
MET A 261
LEU A 309
PHE A 164
ALA A 312
None
0.89A 3nxuB-4js5A:
undetectable
3nxuB-4js5A:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvl FATTY ACID
ALPHA-OXIDASE


(Oryza sativa)
PF03098
(An_peroxidase)
5 PHE A 379
PHE A 272
ILE A 593
ALA A 433
ILE A 146
PLM  A 702 ( 4.7A)
None
None
None
None
1.10A 3nxuB-4kvlA:
undetectable
3nxuB-4kvlA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lj2 CHORISMATE SYNTHASE

(Acinetobacter
baumannii)
PF01264
(Chorismate_synt)
5 LEU A 340
ILE A 230
ALA A 233
ILE A 331
ALA A 328
None
1.16A 3nxuB-4lj2A:
undetectable
3nxuB-4lj2A:
21.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
7 MET A 114
SER A 119
LEU A 210
ILE A 301
ALA A 305
ILE A 369
ALA A 370
None
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
1.04A 3nxuB-4ny4A:
53.1
3nxuB-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
8 PHE A 108
MET A 114
SER A 119
PHE A 241
ILE A 301
ALA A 305
ILE A 369
ALA A 370
2QH  A 602 (-4.4A)
None
2QH  A 602 (-3.9A)
2QH  A 602 (-4.5A)
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
0.81A 3nxuB-4ny4A:
53.1
3nxuB-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
8 PHE A 108
MET A 114
SER A 119
THR A 224
ILE A 301
ALA A 305
ILE A 369
ALA A 370
2QH  A 602 (-4.4A)
None
2QH  A 602 (-3.9A)
None
None
2QH  A 602 ( 3.6A)
HEM  A 601 (-4.7A)
2QH  A 602 ( 3.1A)
0.83A 3nxuB-4ny4A:
53.1
3nxuB-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens)
PF00067
(p450)
6 PHE A 108
SER A 119
THR A 224
ILE A 301
PHE A 304
ALA A 305
2QH  A 602 (-4.4A)
2QH  A 602 (-3.9A)
None
None
2QH  A 602 (-3.3A)
2QH  A 602 ( 3.6A)
1.32A 3nxuB-4ny4A:
53.1
3nxuB-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oem DIPEPTIDYL PEPTIDASE
1 HEAVY CHAIN


(Homo sapiens)
PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc)
5 PHE A  80
SER A 268
THR A  97
ILE A 282
ALA A 287
None
EDO  A 509 (-4.1A)
None
None
None
1.17A 3nxuB-4oemA:
undetectable
3nxuB-4oemA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r4g PUTATIVE LIPOPROTEIN
YCDA


(Bacillus
subtilis)
PF11611
(DUF4352)
PF17118
(DUF5105)
5 PHE A 187
LEU A 347
PHE A 351
ALA A 175
ILE A 197
None
1.05A 3nxuB-4r4gA:
undetectable
3nxuB-4r4gA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tw0 SCAVENGER RECEPTOR
CLASS B MEMBER 2


(Homo sapiens)
PF01130
(CD36)
5 LEU A 324
PHE A  67
PHE A 273
ILE A 301
ALA A 303
None
0.96A 3nxuB-4tw0A:
undetectable
3nxuB-4tw0A:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w6v DI-/TRIPEPTIDE
TRANSPORTER


(Yersinia
enterocolitica)
PF00854
(PTR2)
5 PHE A 186
MET A  45
PHE A 118
PHE A  68
ALA A  69
None
0.83A 3nxuB-4w6vA:
undetectable
3nxuB-4w6vA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy5 ESTERASE

(Rhizomucor
miehei)
PF07859
(Abhydrolase_3)
5 LEU A 106
PHE A  85
ILE A 295
ILE A  46
ALA A  44
None
1.02A 3nxuB-4wy5A:
undetectable
3nxuB-4wy5A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xky DIHYDRODIPICOLINATE
SYNTHASE


(Bacteroides
thetaiotaomicron)
PF00701
(DHDPS)
5 MET A 188
THR A  47
ILE A 151
ALA A 147
ALA A 112
None
1.09A 3nxuB-4xkyA:
undetectable
3nxuB-4xkyA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yg7 SERINE/THREONINE-PRO
TEIN KINASE HIPA


(Escherichia
coli)
PF07804
(HipA_C)
PF13657
(Couple_hipA)
5 PHE D 315
PHE D 236
THR D 328
ALA D 336
ALA D 154
None
1.19A 3nxuB-4yg7D:
undetectable
3nxuB-4yg7D:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zda ISOCITRATE
DEHYDROGENASE (NADP)
ICD2


(Mycolicibacterium
smegmatis)
PF03971
(IDH)
5 SER A 616
LEU A  25
ILE A   8
ALA A  32
ALA A 635
None
1.15A 3nxuB-4zdaA:
undetectable
3nxuB-4zdaA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z


(Homo sapiens)
PF00179
(UQ_con)
5 LEU A 167
PHE A 181
ILE A 135
ALA A 133
ILE A 206
None
1.04A 3nxuB-5a4pA:
undetectable
3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z


(Homo sapiens)
PF00179
(UQ_con)
5 MET A 217
LEU A 167
PHE A 181
ILE A 135
ALA A 133
None
0.73A 3nxuB-5a4pA:
undetectable
3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4p UBIQUITIN-CONJUGATIN
G ENZYME E2 Z


(Homo sapiens)
PF00179
(UQ_con)
5 MET A 217
LEU A 167
PHE A 181
ILE A 135
ILE A 131
None
0.91A 3nxuB-5a4pA:
undetectable
3nxuB-5a4pA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Pseudoalteromonas
atlantica)
PF03480
(DctP)
5 MET A  50
THR A 149
PHE A 242
ILE A  66
ALA A 195
None
1.11A 3nxuB-5cm6A:
undetectable
3nxuB-5cm6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cm6 TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT


(Pseudoalteromonas
atlantica)
PF03480
(DctP)
5 MET A  50
THR A 238
PHE A 242
ILE A  66
ALA A 195
None
PYR  A 401 (-3.8A)
None
None
None
1.15A 3nxuB-5cm6A:
undetectable
3nxuB-5cm6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djw ALPHA-GLUCOSIDASE II

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110)
5 LEU A 490
PHE A 494
ILE A 537
ILE A 482
ALA A 479
None
1.11A 3nxuB-5djwA:
undetectable
3nxuB-5djwA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dlk TQAA

(Penicillium
aethiopicum)
PF00668
(Condensation)
5 LEU A 296
THR A 356
PHE A 307
ILE A 457
ILE A 475
None
0.94A 3nxuB-5dlkA:
undetectable
3nxuB-5dlkA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fyj GP120 ENV ECTODOMAIN

(Human
immunodeficiency
virus 1)
PF00516
(GP120)
5 PHE G 176
PHE G 159
PHE G 309
ALA G 316
ALA G 204
None
1.06A 3nxuB-5fyjG:
undetectable
3nxuB-5fyjG:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN


(Lachnoclostridium
phytofermentans)
PF17167
(Glyco_hydro_36)
5 LEU A 890
ILE A 918
ALA A 895
ILE A 904
ALA A 765
None
1.16A 3nxuB-5h42A:
undetectable
3nxuB-5h42A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbh 30S RIBOSOMAL
PROTEIN US7


(Pyrococcus
abyssi)
PF00177
(Ribosomal_S7)
5 ILE H 111
PHE H 108
ALA H 107
ILE H  71
ALA H 166
None
1.03A 3nxuB-5jbhH:
undetectable
3nxuB-5jbhH:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjp NONRIBOSOMAL PEPTIDE
SYNTHASE


(Streptomyces
sp. MJ635-86F5)
PF00501
(AMP-binding)
5 PHE A  89
PHE A  95
ALA A  77
ILE A  32
ALA A  31
None
1.19A 3nxuB-5jjpA:
undetectable
3nxuB-5jjpA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
2, MITOCHONDRIAL
NADH DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR PROTEIN
7, MITOCHONDRIAL


(Bos taurus)
PF00346
(Complex1_49kDa)
PF01058
(Oxidored_q6)
5 MET D 164
PHE D 178
PHE D 168
ILE B  87
ALA B  89
None
1.19A 3nxuB-5lc5D:
undetectable
3nxuB-5lc5D:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m1q PHAGE TERMINASE
LARGE SUBUNIT


(Thermus phage
G20c)
PF17289
(Terminase_6C)
5 ILE A 291
PHE A 304
ALA A 293
ILE A 355
ALA A 356
None
1.09A 3nxuB-5m1qA:
undetectable
3nxuB-5m1qA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mmh HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR AMPR


(Pseudomonas
aeruginosa)
PF03466
(LysR_substrate)
5 MET A 241
SER A 221
THR A 257
PHE A 147
ALA A 194
None
1.19A 3nxuB-5mmhA:
undetectable
3nxuB-5mmhA:
20.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nv3 RIBULOSE
BISPHOSPHATE
CARBOXYLASE LARGE
CHAIN


(Rhodobacter
sphaeroides)
PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N)
5 THR A  65
PHE A  42
ILE A 310
ILE A 115
ALA A 116
None
1.20A 3nxuB-5nv3A:
undetectable
3nxuB-5nv3A:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ofk GLYCOSIDE HYDROLASE
FAMILY 48


(Caldicellulosiruptor
bescii)
PF00331
(Glyco_hydro_10)
5 THR A  44
ILE A 242
PHE A 236
ILE A 142
ALA A 141
None
1.18A 3nxuB-5ofkA:
undetectable
3nxuB-5ofkA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5okl AFAMIN

(Homo sapiens)
no annotation 5 LEU A 388
PHE A 447
ALA A 448
ILE A 346
ALA A 220
None
1.06A 3nxuB-5oklA:
undetectable
3nxuB-5oklA:
10.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olj DIPEPTIDYL PEPTIDASE
IV


(Porphyromonas
gingivalis)
PF00326
(Peptidase_S9)
PF00930
(DPPIV_N)
5 LEU A 600
THR A 546
ILE A 614
ALA A 612
ILE A 587
None
1.08A 3nxuB-5oljA:
undetectable
3nxuB-5oljA:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swj PROBABLE ATP
SYNTHASE SPAL/MXIB


(Shigella
flexneri)
PF00006
(ATP-synt_ab)
5 LEU A  91
ILE A 229
ALA A 232
ILE A 298
ALA A 300
None
0.91A 3nxuB-5swjA:
undetectable
3nxuB-5swjA:
21.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 5 MET A 114
PHE A 215
PHE A 241
PHE A 304
ALA A 305
None
RIT  A 602 (-4.0A)
RIT  A 602 (-3.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
0.77A 3nxuB-5veuA:
48.9
3nxuB-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 5 MET A 114
SER A 119
ILE A 301
ALA A 305
ALA A 370
None
RIT  A 602 (-3.7A)
RIT  A 602 ( 4.9A)
HEM  A 601 (-3.4A)
RIT  A 602 (-3.3A)
0.73A 3nxuB-5veuA:
48.9
3nxuB-5veuA:
83.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5veu CYTOCHROME P450 3A5

(Homo sapiens)
no annotation 6 MET A 114
SER A 119
PHE A 241
ILE A 301
PHE A 304
ALA A 305
None
RIT  A 602 (-3.7A)
RIT  A 602 (-3.9A)
RIT  A 602 ( 4.9A)
RIT  A 602 (-3.7A)
HEM  A 601 (-3.4A)
0.41A 3nxuB-5veuA:
48.9
3nxuB-5veuA:
83.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER


(Klebsiella
pneumoniae)
PF03390
(2HCT)
5 PHE A  87
THR A 349
ALA A 122
ILE A 420
ALA A 423
None
1.14A 3nxuB-5x9rA:
undetectable
3nxuB-5x9rA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xn8 GLYCEROL
DEHYDROGENASE


(unidentified)
PF00465
(Fe-ADH)
5 SER A 288
ILE A 293
ALA A 355
ILE A 256
ALA A 252
None
1.18A 3nxuB-5xn8A:
undetectable
3nxuB-5xn8A:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y9d ACYL-COENZYME A
OXIDASE 1


(Yarrowia
lipolytica)
no annotation 5 PHE A 542
PHE A 506
PHE A 579
ALA A 346
ILE A 411
None
1.11A 3nxuB-5y9dA:
undetectable
3nxuB-5y9dA:
8.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH SUBUNIT
MBH13 NADH
DEHYDROGENASE
SUBUNIT


(Pyrococcus
furiosus)
no annotation 5 LEU I  18
THR M  86
PHE I  14
ALA M  71
ILE M 230
None
0.99A 3nxuB-6cfwI:
undetectable
3nxuB-6cfwI:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MONOVALENT CATION/H+
ANTIPORTER SUBUNIT F
MONOVALENT CATION/H+
ANTIPORTER SUBUNIT G


(Pyrococcus
furiosus)
no annotation 5 SER C  22
THR B  72
ILE B  16
ILE B  44
ALA B  43
None
1.15A 3nxuB-6cfwC:
undetectable
3nxuB-6cfwC:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6e29 -

(-)
no annotation 5 LEU D 229
PHE D 241
ILE D 217
ALA D 189
ILE D 206
None
1.12A 3nxuB-6e29D:
undetectable
3nxuB-6e29D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6et7 DIGUANYLATE CYCLASE
(GGDEF)
DOMAIN-CONTAINING
PROTEIN


(Idiomarina sp.
A28L)
no annotation 5 SER A 592
ILE A 534
PHE A 535
ILE A 612
ALA A 613
None
1.08A 3nxuB-6et7A:
undetectable
3nxuB-6et7A:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis)
no annotation 5 PHE A 223
THR A 106
ILE A 310
ALA A 306
ILE A 332
None
1.12A 3nxuB-6eu6A:
undetectable
3nxuB-6eu6A:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4


(Mus musculus)
no annotation 5 PHE M 149
LEU M 238
ILE M 230
ALA M 233
ALA M 287
None
1.08A 3nxuB-6g2jM:
undetectable
3nxuB-6g2jM:
10.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g3u -

(-)
no annotation 5 SER A 613
LEU A  24
ILE A   7
ALA A  31
ALA A 632
None
1.04A 3nxuB-6g3uA:
undetectable
3nxuB-6g3uA:
undetectable