SIMILAR PATTERNS OF AMINO ACIDS FOR 3NXU_A_RITA600_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 124
THR A  95
THR A 105
ARG A 114
 None
 0.94A 3nxuA-1dq3A:
0.0		 3nxuA-1dq3A:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hm7 PENTALENENE SYNTHASE

(Streptomyces
exfoliatus) 		no annotation 4 PHE A 192
ARG A 299
LEU A 208
ARG A 292
 None
 1.14A 3nxuA-1hm7A:
0.0		 3nxuA-1hm7A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		4 PHE A 365
ILE A 170
LEU A 215
ARG A 412
 None
None
None
AVG  A 501 (-3.6A)
 1.14A 3nxuA-1iayA:
0.0		 3nxuA-1iayA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itk CATALASE-PEROXIDASE

(Haloarcula
marismortui) 		PF00141
(peroxidase) 		4 ARG A 133
ILE A 120
THR A 407
THR A 304
 None
None
None
HEM  A 800 (-3.4A)
 1.01A 3nxuA-1itkA:
0.0		 3nxuA-1itkA:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02332
(Phenol_Hydrox) 		4 ARG D 419
ILE D 417
THR D 277
ARG D 463
 None
 1.29A 3nxuA-1mhzD:
0.0		 3nxuA-1mhzD:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		4 ILE A 116
LEU A 176
THR A  33
THR A 125
 None
 1.16A 3nxuA-1p3cA:
0.0		 3nxuA-1p3cA:
15.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q5z SIPA

(Salmonella
enterica) 		PF09052
(SipA) 		4 ILE A 609
LEU A 546
THR A 638
THR A 527
 None
 1.28A 3nxuA-1q5zA:
undetectable		 3nxuA-1q5zA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qb4 PHOSPHOENOLPYRUVATE
CARBOXYLASE

(Escherichia
coli) 		PF00311
(PEPcase) 		4 PHE A 719
ARG A 618
ILE A 148
THR A 136
 None
 1.16A 3nxuA-1qb4A:
0.0		 3nxuA-1qb4A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8w GLYCEROL DEHYDRATASE

(Clostridium
butyricum) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 644
LEU A 453
THR A 699
THR A 655
 None
 0.98A 3nxuA-1r8wA:
0.0		 3nxuA-1r8wA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tp7 GENOME POLYPROTEIN

(Rhinovirus A) 		PF00680
(RdRP_1) 		4 ILE A   5
LEU A  14
THR A 156
ARG A 266
 None
 1.03A 3nxuA-1tp7A:
0.0		 3nxuA-1tp7A:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x2i HEF
HELICASE/NUCLEASE

(Pyrococcus
furiosus) 		PF12826
(HHH_2) 		4 ILE A  51
LEU A  16
THR A  64
ARG A  36
 None
 1.06A 3nxuA-1x2iA:
undetectable		 3nxuA-1x2iA:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdq BACTERIAL SULFITE
OXIDASE

(Escherichia
coli) 		PF00174
(Oxidored_molyb) 		4 ARG A 194
ILE A 206
LEU A  70
THR A  65
 MTE  A 301 (-2.8A)
None
None
None
 0.95A 3nxuA-1xdqA:
undetectable		 3nxuA-1xdqA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrc S-ADENOSYLMETHIONINE
SYNTHETASE

(Escherichia
coli) 		PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C) 		4 ILE A 341
LEU A  31
THR A 354
THR A  57
 None
 1.18A 3nxuA-1xrcA:
undetectable		 3nxuA-1xrcA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		4 PHE A 334
ILE A 196
LEU A 100
THR A 149
 None
None
None
MG  A 903 ( 4.6A)
 1.10A 3nxuA-1zefA:
undetectable		 3nxuA-1zefA:
21.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4x ANTITHROMBIN-III

(Homo sapiens) 		PF00079
(Serpin) 		4 ARG I 413
ILE I 421
LEU I 126
THR I  44
 None
 1.21A 3nxuA-2b4xI:
undetectable		 3nxuA-2b4xI:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bv6 HTH-TYPE
TRANSCRIPTIONAL
REGULATOR MGRA

(Staphylococcus
aureus) 		PF01047
(MarR) 		4 ARG A  84
ILE A  96
LEU A  64
THR A  37
 SO4  A1142 (-3.4A)
None
None
None
 1.03A 3nxuA-2bv6A:
undetectable		 3nxuA-2bv6A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcp HYPOTHETICAL PROTEIN
(RAFL09-17-B18)

(Arabidopsis
thaliana) 		PF01417
(ENTH) 		4 ARG A  57
ILE A  54
LEU A  32
THR A 120
 None
 0.71A 3nxuA-2dcpA:
undetectable		 3nxuA-2dcpA:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dj6 HYPOTHETICAL PROTEIN
PH0634

(Pyrococcus
horikoshii) 		PF01242
(PTPS) 		4 ARG A  87
ILE A  88
LEU A 103
ARG A  66
 ARG  A  87 ( 0.6A)
ILE  A  88 ( 0.7A)
LEU  A 103 ( 0.6A)
ARG  A  66 ( 0.6A)
 0.95A 3nxuA-2dj6A:
undetectable		 3nxuA-2dj6A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dzd PYRUVATE CARBOXYLASE

(Geobacillus
thermodenitrificans) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 358
ILE A 345
LEU A 418
ARG A 238
 None
 0.96A 3nxuA-2dzdA:
undetectable		 3nxuA-2dzdA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eae ALPHA-FUCOSIDASE

(Bifidobacterium
bifidum) 		PF14498
(Glyco_hyd_65N_2) 		4 PHE A 686
ILE A 335
THR A 740
THR A 382
 None
 0.80A 3nxuA-2eaeA:
undetectable		 3nxuA-2eaeA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eeo ASPARTATE
1-DECARBOXYLASE

(Thermus
thermophilus) 		PF02261
(Asp_decarbox) 		4 ILE B  49
LEU B  87
THR A  16
ARG B 113
 None
 1.07A 3nxuA-2eeoB:
undetectable		 3nxuA-2eeoB:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3o PYRUVATE
FORMATE-LYASE 2

(Archaeoglobus
fulgidus) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ARG A 770
ILE A 769
LEU A 760
THR A 692
 None
 1.09A 3nxuA-2f3oA:
undetectable		 3nxuA-2f3oA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hr7 INSULIN RECEPTOR

(Homo sapiens) 		PF00757
(Furin-like)
PF01030
(Recep_L_domain) 		4 ILE A 361
LEU A 314
THR A 392
ARG A 371
 None
None
None
SO4  A 602 ( 3.0A)
 1.19A 3nxuA-2hr7A:
undetectable		 3nxuA-2hr7A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxo CELL DIVISION
TOPOLOGICAL
SPECIFICITY FACTOR

(Neisseria
gonorrhoeae) 		PF03776
(MinE) 		4 PHE A   8
ARG A  63
ILE A  62
LEU A  81
 None
 1.24A 3nxuA-2kxoA:
undetectable		 3nxuA-2kxoA:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lg1 A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH) 		4 PHE A  61
LEU A  71
THR A  47
THR A 170
 None
 1.10A 3nxuA-2lg1A:
undetectable		 3nxuA-2lg1A:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2om6 PROBABLE
PHOSPHOSERINE
PHOSPHATASE

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		4 ARG A  48
ILE A  51
LEU A  66
THR A 132
 SO4  A1300 (-2.5A)
None
None
None
 1.23A 3nxuA-2om6A:
undetectable		 3nxuA-2om6A:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q50 GLYOXYLATE
REDUCTASE/HYDROXYPYR
UVATE REDUCTASE

(Homo sapiens) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ARG A 171
ILE A 168
THR A 121
THR A 301
 None
 0.90A 3nxuA-2q50A:
undetectable		 3nxuA-2q50A:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qp4 BILE SALT
SULFOTRANSFERASE

(Homo sapiens) 		PF00685
(Sulfotransfer_1) 		4 PHE A 105
ILE A  71
LEU A  95
THR A  90
 None
 1.19A 3nxuA-2qp4A:
undetectable		 3nxuA-2qp4A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4f 3-HYDROXY-3-METHYLGL
UTARYL-COENZYME A
REDUCTASE

(Homo sapiens) 		PF00368
(HMG-CoA_red) 		4 PHE A 615
ILE A 680
THR A 636
THR A 625
 None
 1.29A 3nxuA-2r4fA:
undetectable		 3nxuA-2r4fA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9h H(+)/CL(-) EXCHANGE
TRANSPORTER CLCA

(Escherichia
coli) 		PF00654
(Voltage_CLC) 		4 ILE A 402
LEU A 411
THR A 151
THR A 365
 None
 1.17A 3nxuA-2r9hA:
undetectable		 3nxuA-2r9hA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wws COAT PROTEIN

(Physalis mottle
virus) 		PF00983
(Tymo_coat) 		4 ILE A 174
LEU A  94
THR A 128
THR A  48
 None
 1.10A 3nxuA-2wwsA:
undetectable		 3nxuA-2wwsA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xpz LEUKOTRIENE A-4
HYDROLASE

(Saccharomyces
cerevisiae) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		4 PHE A 570
ILE A 542
LEU A 583
THR A 530
 None
 1.28A 3nxuA-2xpzA:
undetectable		 3nxuA-2xpzA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 327
LEU A 408
THR A 422
THR A 437
 None
 1.27A 3nxuA-2y8nA:
undetectable		 3nxuA-2y8nA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zwa LEUCINE CARBOXYL
METHYLTRANSFERASE 2

(Saccharomyces
cerevisiae) 		PF04072
(LCM)
PF13418
(Kelch_4) 		4 ARG A  93
ILE A  92
LEU A 312
THR A 320
 None
 1.25A 3nxuA-2zwaA:
undetectable		 3nxuA-2zwaA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3afe HYDROXYLASE,
PUTATIVE

(Mycobacterium
tuberculosis) 		PF02771
(Acyl-CoA_dh_N)
PF08028
(Acyl-CoA_dh_2) 		4 ILE A  88
LEU A 187
THR A 330
THR A  30
 None
 1.25A 3nxuA-3afeA:
1.6		 3nxuA-3afeA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cfi TYPE II SECRETORY
PATHWAY, PSEUDOPILIN
EPSJ

(Vibrio
vulnificus) 		PF11612
(T2SSJ) 		4 PHE B  91
ARG B 186
ILE B 184
LEU B 120
 None
 0.92A 3nxuA-3cfiB:
undetectable		 3nxuA-3cfiB:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		4 PHE A  98
ILE A 129
LEU A 158
THR A 110
 None
 0.97A 3nxuA-3d34A:
undetectable		 3nxuA-3d34A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3daq DIHYDRODIPICOLINATE
SYNTHASE

(Staphylococcus
aureus) 		PF00701
(DHDPS) 		4 ARG A 178
ILE A 179
LEU A 134
THR A 144
 None
 1.27A 3nxuA-3daqA:
undetectable		 3nxuA-3daqA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htz ALANYL-TRNA
SYNTHETASE

(Aquifex
aeolicus) 		PF01411
(tRNA-synt_2c) 		4 ARG A 304
LEU A 316
THR A  88
ARG A 297
 None
 1.24A 3nxuA-3htzA:
undetectable		 3nxuA-3htzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		4 PHE A1212
LEU A 985
THR A1112
THR A1249
 None
 1.23A 3nxuA-3jb9A:
undetectable		 3nxuA-3jb9A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ktw SIGNAL RECOGNITION
PARTICLE 19 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF01922
(SRP19) 		4 ARG A  28
ILE A  33
LEU A  42
THR A  82
 C  C 158 ( 3.2A)
None
None
None
 1.26A 3nxuA-3ktwA:
undetectable		 3nxuA-3ktwA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l78 REGULATORY PROTEIN
SPX

(Streptococcus
mutans) 		PF03960
(ArsC) 		4 ARG A  92
ILE A  32
LEU A  79
THR A  49
 None
 1.10A 3nxuA-3l78A:
undetectable		 3nxuA-3l78A:
15.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m07 PUTATIVE ALPHA
AMYLASE

(Salmonella
enterica) 		PF00128
(Alpha-amylase)
PF11941
(DUF3459) 		4 ILE A 185
LEU A 250
THR A 294
ARG A 109
 None
 1.27A 3nxuA-3m07A:
undetectable		 3nxuA-3m07A:
22.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 325
LEU A  19
THR A  37
THR A  28
 None
 1.26A 3nxuA-3n2bA:
undetectable		 3nxuA-3n2bA:
24.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2o BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Vibrio
vulnificus) 		PF02784
(Orn_Arg_deC_N) 		4 PHE A  85
ILE A 206
LEU A 256
THR A 325
 None
 1.19A 3nxuA-3n2oA:
undetectable		 3nxuA-3n2oA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT

(Ruegeria
pomeroyi) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 409
ILE A 396
LEU A 470
ARG A 294
 None
 0.89A 3nxuA-3n6rA:
undetectable		 3nxuA-3n6rA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3njr PRECORRIN-6Y
METHYLASE

(Rhodobacter
capsulatus) 		no annotation 4 ILE A  62
LEU A  38
THR A  18
THR A 127
 None
None
SAH  A 300 (-3.8A)
None
 0.98A 3nxuA-3njrA:
undetectable		 3nxuA-3njrA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rd8 FUMARATE HYDRATASE
CLASS II

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 PHE A 371
ARG A 269
LEU A 256
THR A  47
 None
 0.88A 3nxuA-3rd8A:
undetectable		 3nxuA-3rd8A:
23.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ss7 D-SERINE DEHYDRATASE

(Escherichia
coli) 		PF00291
(PALP) 		4 PHE X 348
ILE X 163
LEU X 171
ARG X 242
 None
 0.81A 3nxuA-3ss7X:
undetectable		 3nxuA-3ss7X:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ARG A  26
ILE A  23
LEU A 178
ARG A 192
 None
 0.99A 3nxuA-3tqiA:
undetectable		 3nxuA-3tqiA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmn DEXTRANASE

(Streptococcus
mutans) 		PF13199
(Glyco_hydro_66) 		4 ILE A 583
LEU A 541
THR A 521
ARG A 574
 None
 0.91A 3nxuA-3vmnA:
undetectable		 3nxuA-3vmnA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqr PUTATIVE
OXIDOREDUCTASE

(Aeropyrum
pernix) 		PF01266
(DAO) 		4 ILE A 116
LEU A  89
THR A 130
ARG A 124
 None
 1.12A 3nxuA-3vqrA:
undetectable		 3nxuA-3vqrA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d0n A-KINASE ANCHOR
PROTEIN 13

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 PHE B2226
LEU B2236
THR B2212
THR B2335
 None
 1.24A 3nxuA-4d0nB:
undetectable		 3nxuA-4d0nB:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gij PSEUDOURIDINE-5'-PHO
SPHATE GLYCOSIDASE

(Escherichia
coli) 		PF04227
(Indigoidine_A) 		4 PHE A 128
ILE A   6
LEU A  99
THR A 156
 None
 1.21A 3nxuA-4gijA:
undetectable		 3nxuA-4gijA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 PHE A 240
ILE A 198
THR A 225
THR A  87
 None
None
None
FAD  A 601 (-3.6A)
 1.14A 3nxuA-4j57A:
undetectable		 3nxuA-4j57A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4joc LYSOPHOSPHATIDIC
ACID PHOSPHATASE
TYPE 6

(Homo sapiens) 		PF00328
(His_Phos_2) 		4 ARG A 326
ILE A 161
LEU A 180
THR A 360
 None
 1.12A 3nxuA-4jocA:
undetectable		 3nxuA-4jocA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjy LEUKOCYTE SURFACE
ANTIGEN CD47

(Homo sapiens) 		PF08204
(V-set_CD47) 		4 PHE A  24
ILE A  47
THR A 107
THR A  18
 None
None
SO4  A 201 (-3.9A)
None
 0.97A 3nxuA-4kjyA:
undetectable		 3nxuA-4kjyA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mni TRAP DICARBOXYLATE
TRANSPORTER-DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 ILE A  43
LEU A 214
THR A  76
THR A 220
 None
 1.19A 3nxuA-4mniA:
undetectable		 3nxuA-4mniA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt1 DRUG EFFLUX PROTEIN

(Neisseria
gonorrhoeae) 		PF00873
(ACR_tran) 		4 PHE A 176
ILE A 167
THR A 327
ARG A 174
 None
 1.15A 3nxuA-4mt1A:
undetectable		 3nxuA-4mt1A:
18.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		4 ARG A 105
ILE A 120
THR A 224
ARG A 372
 HEM  A 601 ( 2.8A)
None
None
None
 0.54A 3nxuA-4ny4A:
53.3		 3nxuA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		4 ARG A 105
ILE A 120
THR A 309
ARG A 372
 HEM  A 601 ( 2.8A)
None
2QH  A 602 ( 3.7A)
None
 0.45A 3nxuA-4ny4A:
53.3		 3nxuA-4ny4A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ny4 CYTOCHROME P450 3A4

(Homo sapiens) 		PF00067
(p450) 		4 PHE A  57
ARG A 105
ILE A 120
ARG A 372
 None
HEM  A 601 ( 2.8A)
None
None
 1.21A 3nxuA-4ny4A:
53.3		 3nxuA-4ny4A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 ARG A  74
LEU A  49
THR A  64
ARG A  70
 None
 1.03A 3nxuA-4pf1A:
undetectable		 3nxuA-4pf1A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxl CYTOSOLIC ALDEHYDE
DEHYDROGENASE RF2C

(Zea mays) 		PF00171
(Aldedh) 		4 PHE A 336
ILE A  53
THR A 173
ARG A  45
 None
 1.18A 3nxuA-4pxlA:
undetectable		 3nxuA-4pxlA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q58 PLECTIN

(Homo sapiens) 		PF00307
(CH) 		4 ARG A 111
ILE A 120
LEU A  76
ARG A 113
 None
 1.00A 3nxuA-4q58A:
undetectable		 3nxuA-4q58A:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpp PROTEIN ARGININE
N-METHYLTRANSFERASE
6

(Homo sapiens) 		PF13649
(Methyltransf_25) 		4 ILE A 196
LEU A 325
THR A 335
THR A 227
 None
 1.04A 3nxuA-4qppA:
undetectable		 3nxuA-4qppA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tps SPORULATION
INHIBITOR OF
REPLICATION PROTEIN
SIRA

(Bacillus
subtilis) 		PF10747
(SirA) 		4 ILE A  80
LEU A  65
THR A   7
THR A  72
 None
 1.02A 3nxuA-4tpsA:
undetectable		 3nxuA-4tpsA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udj UHGB_MP

(uncultured
organism) 		PF04041
(Glyco_hydro_130) 		4 ARG A 106
ILE A 218
THR A 132
THR A 307
 None
 1.27A 3nxuA-4udjA:
undetectable		 3nxuA-4udjA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzs BETA-GALACTOSIDASE

(Bifidobacterium
bifidum) 		PF02449
(Glyco_hydro_42)
PF08532
(Glyco_hydro_42M)
PF08533
(Glyco_hydro_42C) 		4 PHE A 297
ILE A 665
THR A 408
ARG A 342
 None
 1.25A 3nxuA-4uzsA:
undetectable		 3nxuA-4uzsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ww5 EKC/KEOPS COMPLEX
SUBUNIT CGI121

(Saccharomyces
cerevisiae) 		PF08617
(CGI-121) 		4 ILE B  12
LEU B 107
THR B  71
ARG B 179
 None
 1.08A 3nxuA-4ww5B:
undetectable		 3nxuA-4ww5B:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a4m HYDROGENASE-1 SMALL
CHAIN

(Escherichia
coli) 		PF01058
(Oxidored_q6)
PF14720
(NiFe_hyd_SSU_C) 		4 ILE S 110
LEU S  42
THR S  18
ARG S  26
 None
 1.19A 3nxuA-5a4mS:
undetectable		 3nxuA-5a4mS:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b1q U14 PROTEIN

(Human
betaherpesvirus
6B) 		PF04637
(Herpes_pp85) 		4 ILE A 327
LEU A  77
THR A 284
THR A  67
 None
 1.13A 3nxuA-5b1qA:
undetectable		 3nxuA-5b1qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d8g TRYPTOPHANASE

(Escherichia
coli) 		PF01212
(Beta_elim_lyase) 		4 ILE A  90
LEU A 318
THR A  60
ARG A 230
 None
 1.03A 3nxuA-5d8gA:
undetectable		 3nxuA-5d8gA:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		4 ILE A 161
THR A 166
THR A  98
ARG A  49
 None
 1.19A 3nxuA-5diyA:
undetectable		 3nxuA-5diyA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djq CBB3-TYPE CYTOCHROME
C OXIDASE SUBUNIT
CCON1

(Pseudomonas
stutzeri) 		PF00115
(COX1) 		4 ILE A 306
LEU A 301
THR A 389
THR A 293
 None
 1.21A 3nxuA-5djqA:
0.0		 3nxuA-5djqA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmq REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H P80

(Murine leukemia
virus) 		PF00075
(RNase_H)
PF00078
(RVT_1) 		4 ILE A 617
LEU A 624
THR A 582
THR A 505
 None
 1.08A 3nxuA-5dmqA:
undetectable		 3nxuA-5dmqA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dz7 POLYKETIDE
BIOSYNTHESIS PROTEIN
PKSE

(Bacillus
subtilis) 		PF00698
(Acyl_transf_1) 		4 ILE A 167
LEU A 139
THR A 245
THR A 177
 None
 1.09A 3nxuA-5dz7A:
undetectable		 3nxuA-5dz7A:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fav CHOLINE
TRIMETHYLAMINE-LYASE

(Desulfovibrio
alaskensis) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 ILE A 742
LEU A 777
THR A 434
ARG A 818
 None
 0.99A 3nxuA-5favA:
undetectable		 3nxuA-5favA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5foe GDP-FUCOSE PROTEIN
O-FUCOSYLTRANSFERASE
2,THROMBOSPONDIN-1

(Caenorhabditis
elegans;
Homo sapiens) 		PF00090
(TSP_1)
PF10250
(O-FucT) 		4 PHE A 185
ARG A 152
LEU A 200
THR A 219
 None
 1.00A 3nxuA-5foeA:
undetectable		 3nxuA-5foeA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fx8 LINOLEATE
11-LIPOXYGENASE

(Gaeumannomyces
avenae) 		PF00305
(Lipoxygenase) 		4 PHE A 452
ILE A  92
THR A 307
THR A 474
 None
 1.27A 3nxuA-5fx8A:
undetectable		 3nxuA-5fx8A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gyz LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding) 		4 ILE A 257
LEU A  96
THR A 346
ARG A 213
 None
 1.20A 3nxuA-5gyzA:
undetectable		 3nxuA-5gyzA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc8 PRENYLTRANSFERENCE
FOR PROTEIN

(Lavandula
lanata) 		PF01255
(Prenyltransf) 		4 ILE A  74
LEU A 260
THR A 235
ARG A 167
 ISY  A 405 (-4.7A)
None
None
None
 1.18A 3nxuA-5hc8A:
undetectable		 3nxuA-5hc8A:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hv6 PHOSPHOENOLPYRUVATE
SYNTHASE

(Listeria
monocytogenes) 		PF01326
(PPDK_N) 		4 PHE A   8
ILE A  92
LEU A 146
THR A 103
 None
 0.96A 3nxuA-5hv6A:
undetectable		 3nxuA-5hv6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1k TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 ILE A 142
LEU A 264
THR A 151
ARG A 252
 None
 1.28A 3nxuA-5j1kA:
undetectable		 3nxuA-5j1kA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)

(Helicobacter
pylori) 		PF01551
(Peptidase_M23) 		4 ILE B 142
LEU B 264
THR B 151
ARG B 252
 None
 1.28A 3nxuA-5j1lB:
undetectable		 3nxuA-5j1lB:
17.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 ILE A 257
LEU A  96
THR A 346
ARG A 213
 None
 1.06A 3nxuA-5kyvA:
undetectable		 3nxuA-5kyvA:
24.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lp8 E3 UBIQUITIN-PROTEIN
LIGASE HUWE1

(Homo sapiens) 		no annotation 4 ILE B4364
LEU B4347
THR B4266
ARG B4283
 None
 1.06A 3nxuA-5lp8B:
undetectable		 3nxuA-5lp8B:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lqd ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE

(Streptomyces
venezuelae) 		PF00982
(Glyco_transf_20) 		4 LEU A 382
THR A 200
THR A 407
ARG A 360
 None
 1.27A 3nxuA-5lqdA:
undetectable		 3nxuA-5lqdA:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 PHE A 667
ILE A 823
LEU A 826
THR A 777
 None
 1.22A 3nxuA-5nn8A:
undetectable		 3nxuA-5nn8A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ot1 PULLULANASE TYPE II,
GH13 FAMILY

(Thermococcus
kodakarensis) 		no annotation 4 PHE A 514
ARG A 501
ILE A 416
THR A 385
 None
 1.27A 3nxuA-5ot1A:
undetectable		 3nxuA-5ot1A:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t58 KLLA0C15939P
KLLA0D15741P

(Kluyveromyces
lactis) 		PF08202
(MIS13)
PF08641
(Mis14) 		4 ILE D 301
LEU N  55
THR D 290
ARG N  31
 None
 1.27A 3nxuA-5t58D:
undetectable		 3nxuA-5t58D:
14.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t98 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF16355
(DUF4982) 		4 PHE A 787
ILE A 762
LEU A 776
THR A 797
 None
 0.95A 3nxuA-5t98A:
undetectable		 3nxuA-5t98A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		4 ILE A 281
LEU A 371
THR A 236
THR A 375
 None
 1.10A 3nxuA-5tbfA:
undetectable		 3nxuA-5tbfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u7z ACID CERAMIDASE

(Homo sapiens) 		no annotation 4 ILE A 135
LEU A 127
THR A 123
ARG A  61
 None
None
None
SO4  A 202 (-2.7A)
 1.09A 3nxuA-5u7zA:
undetectable		 3nxuA-5u7zA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uah RNA POLYMERASE SIGMA
FACTOR RPOD

(Escherichia
coli) 		PF00140
(Sigma70_r1_2)
PF04539
(Sigma70_r3)
PF04542
(Sigma70_r2)
PF04545
(Sigma70_r4)
PF04546
(Sigma70_ner) 		4 ILE F 235
LEU F 353
THR F 142
THR F 311
 None
 1.15A 3nxuA-5uahF:
undetectable		 3nxuA-5uahF:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis) 		PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 PHE A 351
ILE A 338
LEU A 411
ARG A 232
 None
 0.91A 3nxuA-5vywA:
undetectable		 3nxuA-5vywA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w81 CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR

(Danio rerio) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane)
PF14396
(CFTR_R) 		4 ILE A1211
LEU A1254
THR A1424
THR A1264
 None
 1.26A 3nxuA-5w81A:
undetectable		 3nxuA-5w81A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xup TELOMERIC
REPEAT-BINDING
FACTOR 1

(Homo sapiens) 		no annotation 4 ILE A 108
THR A 254
THR A 130
ARG A  88
 None
 1.07A 3nxuA-5xupA:
undetectable		 3nxuA-5xupA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cri -

(-) 		no annotation 4 ILE G 508
LEU G 472
THR G 455
THR G 519
 None
 1.24A 3nxuA-6criG:
undetectable		 3nxuA-6criG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fcx METHYLENETETRAHYDROF
OLATE REDUCTASE

(Homo sapiens) 		no annotation 4 PHE A  64
ARG A 295
ILE A 299
LEU A 333
 None
CIT  A 703 (-3.1A)
None
None
 1.17A 3nxuA-6fcxA:
undetectable		 3nxuA-6fcxA:
9.30