SIMILAR PATTERNS OF AMINO ACIDS FOR 3NUV_A_ASDA126

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyx CYOA

(Escherichia
coli) 		PF00116
(COX2)
PF06481
(COX_ARM) 		5 SER A 181
LEU A 193
VAL A 161
ALA A 222
PHE A 155
 None
 1.34A 3nuvA-1cyxA:
0.0		 3nuvA-1cyxA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ggp PROTEIN (LECTIN 1 A
CHAIN)

(Trichosanthes
kirilowii) 		PF00161
(RIP) 		5 SER A  94
PHE A  99
VAL A  66
ASN A 111
ALA A  74
 None
 1.49A 3nuvA-1ggpA:
0.0		 3nuvA-1ggpA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iay 1-AMINOCYCLOPROPANE-
1-CARBOXYLATE
SYNTHASE 2

(Solanum
lycopersicum) 		PF00155
(Aminotran_1_2) 		5 TYR A 274
LEU A 318
PHE A 105
PHE A 317
PHE A 331
 None
 1.15A 3nuvA-1iayA:
0.0		 3nuvA-1iayA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l9w 3-DEHYDROQUINATE
DEHYDRATASE AROD

(Salmonella
enterica) 		PF01487
(DHquinase_I) 		5 PHE A 225
SER A  21
PHE A 145
MET A 203
ALA A 172
 DHS  A 301 (-3.9A)
DHS  A 301 (-3.0A)
None
DHS  A 301 ( 4.3A)
DHS  A 301 ( 4.6A)
 1.42A 3nuvA-1l9wA:
0.0		 3nuvA-1l9wA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzr 2,5-DIKETO-D-GLUCONA
TE REDUCTASE A

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		5 PHE A 141
PHE A 274
VAL A 111
MET A 124
ALA A 120
 None
GOL  A 910 ( 4.6A)
None
None
None
 1.29A 3nuvA-1mzrA:
0.0		 3nuvA-1mzrA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ry2 ACETYL-COENZYME A
SYNTHETASE 1

(Saccharomyces
cerevisiae) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 TYR A 454
LEU A 433
VAL A 407
ALA A 360
PHE A 358
 None
 1.45A 3nuvA-1ry2A:
0.0		 3nuvA-1ry2A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t9k PROBABLE
METHYLTHIORIBOSE-1-P
HOSPHATE ISOMERASE

(Thermotoga
maritima) 		PF01008
(IF-2B) 		5 SER A  11
LEU A  15
PHE A  59
VAL A  62
PHE A 115
 None
 1.38A 3nuvA-1t9kA:
undetectable		 3nuvA-1t9kA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaa ALPHA-AMYLASE

(Aspergillus
niger) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		5 TYR A  37
LEU A  15
PHE A  94
PHE A  13
ASN A  91
 None
 1.42A 3nuvA-2aaaA:
1.5		 3nuvA-2aaaA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bol SMALL HEAT SHOCK
PROTEIN

(Taenia saginata) 		PF00011
(HSP20) 		5 LEU A 162
PHE A 114
VAL A 116
MET A  66
PHE A  58
 None
 1.47A 3nuvA-2bolA:
undetectable		 3nuvA-2bolA:
16.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3n GLUTATHIONE
S-TRANSFERASE THETA
1

(Homo sapiens) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		5 SER A  11
LEU A  35
PHE A  45
ASN A  49
ALA A  56
 None
 1.30A 3nuvA-2c3nA:
undetectable		 3nuvA-2c3nA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ewy BETA-SECRETASE 2

(Homo sapiens) 		PF00026
(Asp) 		5 LEU A 135
PHE A  54
VAL A 113
ALA A 160
PHE A 111
 None
 1.37A 3nuvA-2ewyA:
undetectable		 3nuvA-2ewyA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jl4 MALEYLPYRUVATE
ISOMERASE

(Ralstonia sp.
U2) 		PF13410
(GST_C_2)
PF13417
(GST_N_3) 		5 SER A   9
LEU A  33
PHE A  43
ASN A  47
ALA A  54
 GSH  A1213 (-3.0A)
GSH  A1213 ( 4.4A)
None
None
None
 1.38A 3nuvA-2jl4A:
undetectable		 3nuvA-2jl4A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zsi PROBABLE GIBBERELLIN
RECEPTOR GID1L1

(Arabidopsis
thaliana) 		PF07859
(Abhydrolase_3) 		5 ASN A 218
LEU A 282
VAL A 333
ALA A 286
PHE A 321
 None
 1.39A 3nuvA-2zsiA:
undetectable		 3nuvA-2zsiA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxj RAS
GTPASE-ACTIVATING
PROTEIN SYNGAP

(Rattus
norvegicus) 		PF00168
(C2)
PF00616
(RasGAP) 		5 SER A 575
LEU A 649
PHE A 546
VAL A 539
MET A 483
 None
 1.48A 3nuvA-3bxjA:
undetectable		 3nuvA-3bxjA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec1 YQEH GTPASE

(Geobacillus
stearothermophilus) 		PF01926
(MMR_HSR1) 		5 LEU A 253
PHE A 277
VAL A 343
ALA A 265
PHE A 337
 None
 1.46A 3nuvA-3ec1A:
undetectable		 3nuvA-3ec1A:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h90 FERROUS-IRON EFFLUX
PUMP FIEF

(Escherichia
coli) 		PF01545
(Cation_efflux)
PF16916
(ZT_dimer) 		5 SER A  21
LEU A 131
PHE A 134
VAL A 138
ALA A 146
 None
 1.18A 3nuvA-3h90A:
undetectable		 3nuvA-3h90A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiq VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 PHE A 253
LEU A 205
VAL A 242
ALA A 215
PHE A 224
 None
 1.23A 3nuvA-3hiqA:
undetectable		 3nuvA-3hiqA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hiw VACUOLAR SAPORIN

(Saponaria
officinalis) 		PF00161
(RIP) 		5 PHE A 253
LEU A 205
VAL A 242
ALA A 215
PHE A 224
 None
 1.21A 3nuvA-3hiwA:
undetectable		 3nuvA-3hiwA:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzs MONOFUNCTIONAL
GLYCOSYLTRANSFERASE

(Staphylococcus
aureus) 		PF00912
(Transgly) 		5 VAL A 223
ASN A 245
MET A 249
ALA A  95
PHE A  96
 M0E  A 901 (-4.8A)
None
None
None
None
 1.45A 3nuvA-3hzsA:
undetectable		 3nuvA-3hzsA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jby V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Danio rerio) 		PF12940
(RAG1) 		5 TYR A 578
LEU A 709
PHE A 724
PHE A 720
VAL A 613
 None
 1.43A 3nuvA-3jbyA:
undetectable		 3nuvA-3jbyA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k6r PUTATIVE TRANSFERASE
PH0793

(Pyrococcus
horikoshii) 		PF02475
(Met_10) 		5 LEU A 271
PHE A 237
VAL A 251
MET A 132
ALA A 211
 None
 1.36A 3nuvA-3k6rA:
undetectable		 3nuvA-3k6rA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9r CD1B3

(Bos taurus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		5 LEU A 118
PHE A 144
PHE A  94
VAL A  81
PHE A  77
 L9R  A 284 ( 4.4A)
L9R  A 284 (-4.4A)
None
L9R  A 284 ( 4.0A)
L9R  A 284 (-4.8A)
 1.49A 3nuvA-3l9rA:
undetectable		 3nuvA-3l9rA:
20.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		5 ASN A  40
LEU A  61
VAL A  88
MET A 116
ALA A 118
 EQU  A 200 (-3.5A)
None
None
EQU  A 200 (-4.9A)
EQU  A 200 ( 4.1A)
 1.15A 3nuvA-3owuA:
21.9		 3nuvA-3owuA:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		5 ASN A  40
PHE A  56
VAL A  88
MET A 116
ALA A 118
 EQU  A 200 (-3.5A)
None
None
EQU  A 200 (-4.9A)
EQU  A 200 ( 4.1A)
 0.88A 3nuvA-3owuA:
21.9		 3nuvA-3owuA:
34.85
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3owu STEROID
DELTA-ISOMERASE

(Pseudomonas
putida) 		PF12680
(SnoaL_2) 		5 TYR A  16
ASN A  40
PHE A  56
MET A 116
ALA A 118
 EQU  A 200 (-4.5A)
EQU  A 200 (-3.5A)
None
EQU  A 200 (-4.9A)
EQU  A 200 ( 4.1A)
 0.52A 3nuvA-3owuA:
21.9		 3nuvA-3owuA:
34.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfi TRANSCRIPTIONAL
REGULATOR

(Enterococcus
faecalis) 		PF03816
(LytR_cpsA_psr) 		5 PHE A  62
LEU A  66
VAL A 221
ALA A 263
PHE A 264
 None
 1.49A 3nuvA-3qfiA:
undetectable		 3nuvA-3qfiA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rl3 METALLOPHOSPHOESTERA
SE MPPED2

(Rattus
norvegicus) 		PF00149
(Metallophos) 		5 SER A 159
LEU A 103
VAL A  96
ALA A 115
PHE A 122
 None
 1.40A 3nuvA-3rl3A:
undetectable		 3nuvA-3rl3A:
17.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3t8u STEROID
DELTA-ISOMERASE

(Comamonas
testosteroni) 		PF12680
(SnoaL_2) 		9 PHE A  54
SER A  58
LEU A  63
PHE A  82
PHE A  86
VAL A  95
MET A 112
ALA A 114
PHE A 116
 None
 0.74A 3nuvA-3t8uA:
24.3		 3nuvA-3t8uA:
96.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4axn CHITINASE C1

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 PHE A  30
SER A 102
LEU A 136
ALA A 204
PHE A 202
 ACT  A1331 (-3.8A)
None
None
None
None
 1.48A 3nuvA-4axnA:
undetectable		 3nuvA-4axnA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4byf UNCONVENTIONAL
MYOSIN-IC

(Homo sapiens) 		PF00063
(Myosin_head)
PF00612
(IQ) 		5 TYR A 231
LEU A 303
VAL A 294
ALA A 340
PHE A 284
 None
 1.43A 3nuvA-4byfA:
undetectable		 3nuvA-4byfA:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqv PROBABLE PEPTIDE
SYNTHETASE NRP
(PEPTIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF07993
(NAD_binding_4) 		5 TYR A 228
SER A 153
PHE A 253
VAL A 337
ASN A 158
 None
 1.25A 3nuvA-4dqvA:
undetectable		 3nuvA-4dqvA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2a CHOLESTERYL ESTER
TRANSFER PROTEIN

(Homo sapiens) 		PF01273
(LBP_BPI_CETP)
PF02886
(LBP_BPI_CETP_C) 		5 PHE A 429
LEU A 455
PHE A 265
VAL A 269
PHE A 236
 2OB  A 606 (-3.5A)
None
PCW  A 607 (-4.4A)
None
PCW  A 607 (-4.5A)
 1.40A 3nuvA-4f2aA:
1.8		 3nuvA-4f2aA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g8d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Ochrobactrum
sp. T63) 		PF00561
(Abhydrolase_1) 		5 PHE A 221
SER A 163
PHE A 152
VAL A 177
ALA A 147
 None
 1.43A 3nuvA-4g8dA:
undetectable		 3nuvA-4g8dA:
19.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		5 ASN A 149
PHE A 383
PHE A 447
PHE A 223
PHE A 154
 NAD  A 601 (-3.3A)
NAD  A 601 (-3.7A)
NAD  A 601 (-4.5A)
NAD  A 601 (-4.8A)
NAD  A 601 (-4.5A)
 1.48A 3nuvA-4go4A:
undetectable		 3nuvA-4go4A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o26 TELOMERASE REVERSE
TRANSCRIPTASE

(Oryzias latipes) 		PF12009
(Telomerase_RBD) 		5 TYR A 394
LEU A 436
PHE A 431
MET A 326
ALA A 526
 None
None
None
SO4  A 608 (-4.8A)
None
 1.37A 3nuvA-4o26A:
undetectable		 3nuvA-4o26A:
18.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnw NADPH DEHYDROGENASE
1

(Saccharomyces
pastorianus) 		PF00724
(Oxidored_FMN) 		5 ASN A 350
PHE A 349
PHE A 222
MET A 242
ALA A 220
 None
EDO  A 403 ( 3.9A)
EDO  A 409 ( 4.7A)
None
None
 1.44A 3nuvA-4rnwA:
undetectable		 3nuvA-4rnwA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 TYR A 114
LEU A 220
PHE A 155
VAL A 242
ALA A 359
 None
None
HEM  A 501 ( 4.9A)
HEM  A 501 ( 4.1A)
HEM  A 501 (-3.4A)
 1.45A 3nuvA-4tpnA:
undetectable		 3nuvA-4tpnA:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tqk LECTIN 2

(Agrocybe
aegerita) 		PF13517
(VCBS) 		5 ASN A  88
PHE A  42
PHE A  25
VAL A  23
ASN A  92
 None
 1.31A 3nuvA-4tqkA:
undetectable		 3nuvA-4tqkA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d5x PUTATIVE
TRANSCRIPTION FACTOR

(Chaetomium
thermophilum) 		PF00447
(HSF_DNA-bind) 		5 PHE B  43
LEU B  82
PHE B  91
VAL B  71
PHE B  69
 None
 1.16A 3nuvA-5d5xB:
undetectable		 3nuvA-5d5xB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dd4 TRANSCRIPTIONAL
REGULATOR ARAR

(Bacteroides
thetaiotaomicron) 		PF00293
(NUDIX) 		5 PHE A 223
LEU A 156
PHE A  22
MET A 189
PHE A 182
 None
 1.38A 3nuvA-5dd4A:
undetectable		 3nuvA-5dd4A:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e0c CELLULASE

(Bacillus sp.
BG-CS10) 		PF00150
(Cellulase)
PF03442
(CBM_X2) 		5 TYR A 524
PHE A 482
VAL A 458
ALA A 451
PHE A 453
 None
 1.37A 3nuvA-5e0cA:
undetectable		 3nuvA-5e0cA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghs SSDNA-SPECIFIC
EXONUCLEASE

(Thermococcus
kodakarensis) 		PF02272
(DHHA1) 		5 LEU A 319
VAL A 158
ASN A 152
MET A 148
ALA A 145
 None
 1.32A 3nuvA-5ghsA:
undetectable		 3nuvA-5ghsA:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1z PUTATIVE CYP ALKANE
HYDROXYLASE
CYP153D17

(Sphingomonas
sp. PAMC 26605) 		PF00067
(p450) 		5 PHE A 158
LEU A 241
PHE A  91
VAL A 357
PHE A 110
 None
HEM  A 501 (-4.4A)
HEM  A 501 (-4.0A)
HEM  A 501 (-4.9A)
HEM  A 501 (-4.3A)
 1.45A 3nuvA-5h1zA:
undetectable		 3nuvA-5h1zA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7w VENOM
5'-NUCLEOTIDASE

(Naja atra) 		no annotation 5 ASN A 245
SER A 521
ASN A  36
ALA A 282
PHE A 283
 ZN  A 605 ( 4.8A)
ZN  A 605 ( 4.1A)
None
None
None
 1.47A 3nuvA-5h7wA:
undetectable		 3nuvA-5h7wA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i5j NITROUS-OXIDE
REDUCTASE

(Shewanella
denitrificans) 		no annotation 5 PHE A 215
PHE A 351
VAL A 273
ALA A 240
PHE A 248
 None
 1.47A 3nuvA-5i5jA:
undetectable		 3nuvA-5i5jA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7q PUTATIVE CATHEPSIN D

(Ixodes ricinus) 		no annotation 5 LEU A 319
PHE A 156
PHE A 335
VAL A 333
ALA A 128
 None
 1.30A 3nuvA-5n7qA:
undetectable		 3nuvA-5n7qA:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 5 TYR A 153
SER A  82
PHE A  99
PHE A  80
MET A 106
 None
 1.44A 3nuvA-5oglA:
undetectable		 3nuvA-5oglA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 5 TYR A 411
LEU A 351
PHE A 354
MET A 388
ALA A 368
 None
 1.47A 3nuvA-5ta1A:
undetectable		 3nuvA-5ta1A:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tcb PELA

(Pseudomonas
aeruginosa) 		PF03537
(Glyco_hydro_114) 		5 LEU A 291
VAL A  72
ASN A 199
ALA A 216
PHE A 197
 None
 1.45A 3nuvA-5tcbA:
undetectable		 3nuvA-5tcbA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqb 60S RIBOSOMAL
PROTEIN L4-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00573
(Ribosomal_L4) 		5 PHE A  27
SER A 130
LEU A 136
PHE A 254
VAL A 146
 None
EDO  A 301 (-4.2A)
EDO  A 301 (-4.1A)
EDO  A 301 (-4.1A)
None
 1.40A 3nuvA-5tqbA:
undetectable		 3nuvA-5tqbA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yud BACULOVIRAL IAP
REPEAT-CONTAINING
PROTEIN 1E

(Mus musculus) 		no annotation 5 PHE A1040
LEU A 982
VAL A1023
ALA A1047
PHE A1024
 None
 1.16A 3nuvA-5yudA:
undetectable		 3nuvA-5yudA:
19.20