SIMILAR PATTERNS OF AMINO ACIDS FOR 3NS1_L_PM6L1_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 ARG B1712
PHE B1867
ALA B1863
ALA B1864
 None
 0.86A 3ns1L-1a9xB:
undetectable		 3ns1L-1a9xB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dy2 COLLAGEN ALPHA1(XV)
CHAIN

(Mus musculus) 		PF06482
(Endostatin) 		4 PHE A 106
THR A 117
LEU A 115
ALA A 109
 None
 0.96A 3ns1L-1dy2A:
0.0		 3ns1L-1dy2A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 0.95A 3ns1L-1e08A:
0.0		 3ns1L-1e08A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ARG A 756
LEU A 722
ALA A 742
ALA A 743
 None
 0.99A 3ns1L-1ewrA:
0.2		 3ns1L-1ewrA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyw PHOSPHOTRIESTERASE

(Brevundimonas
diminuta) 		PF02126
(PTE) 		4 THR A 128
LEU A 130
ALA A 186
ALA A 187
 None
 0.92A 3ns1L-1eywA:
0.0		 3ns1L-1eywA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 ARG A 316
LEU A 310
ALA A  91
ALA A  92
 None
 1.00A 3ns1L-1j33A:
0.0		 3ns1L-1j33A:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k44 NUCLEOSIDE
DIPHOSPHATE KINASE

(Mycobacterium
tuberculosis) 		PF00334
(NDK) 		4 SER A 119
THR A   5
ALA A  73
ALA A  74
 None
 0.99A 3ns1L-1k44A:
0.5		 3ns1L-1k44A:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.43A 3ns1L-1kcxA:
undetectable		 3ns1L-1kcxA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		8 GLU A 802
SER A 876
ARG A 880
PHE A 914
THR A1010
LEU A1014
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
None
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.32A 3ns1L-1n5xA:
54.6		 3ns1L-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 ARG B 192
PHE B 191
THR B  54
ALA B 131
 PO4  B 902 (-4.2A)
None
None
None
 0.72A 3ns1L-1nzyB:
undetectable		 3ns1L-1nzyB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tvc METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 SER A  61
THR A  58
LEU A 102
ALA A  96
 FDA  A 252 ( 4.8A)
None
None
None
 1.01A 3ns1L-1tvcA:
undetectable		 3ns1L-1tvcA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v72 ALDOLASE

(Pseudomonas
putida) 		PF01212
(Beta_elim_lyase) 		4 GLU A  98
SER A 207
LEU A  76
ALA A 101
 None
 0.92A 3ns1L-1v72A:
undetectable		 3ns1L-1v72A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.85A 3ns1L-1vb3A:
undetectable		 3ns1L-1vb3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsg VARIANT SURFACE
GLYCOPROTEIN MITAT
1.2

(Trypanosoma
brucei) 		PF00913
(Trypan_glycop) 		4 SER A  88
LEU A  80
ALA A  36
ALA A  35
 None
 0.98A 3ns1L-1vsgA:
undetectable		 3ns1L-1vsgA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wwm HYPOTHETICAL PROTEIN
TT2028

(Thermus
thermophilus) 		no annotation 4 PHE A 148
LEU A  45
ALA A  67
ALA A  70
 None
 0.93A 3ns1L-1wwmA:
undetectable		 3ns1L-1wwmA:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a30 DEOXYCYTIDINE KINASE

(Homo sapiens) 		PF01712
(dNK) 		4 THR A 181
LEU A 205
ALA A  31
ALA A  32
 None
 0.97A 3ns1L-2a30A:
undetectable		 3ns1L-2a30A:
16.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aja ANKYRIN REPEAT
FAMILY PROTEIN

(Legionella
pneumophila) 		no annotation 4 PHE A 132
LEU A 141
ALA A 136
ALA A 135
 None
 0.77A 3ns1L-2ajaA:
undetectable		 3ns1L-2ajaA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2efe SIMILARITY TO
VACUOLAR PROTEIN
SORTING-ASSOCIATED
PROTEIN VPS9
SMALL GTP-BINDING
PROTEIN-LIKE

(Arabidopsis
thaliana) 		PF00071
(Ras)
PF02204
(VPS9) 		4 SER B  49
PHE B  47
ALA A 224
ALA A 223
 None
 0.91A 3ns1L-2efeB:
undetectable		 3ns1L-2efeB:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gpy O-METHYLTRANSFERASE

(Bacillus
halodurans) 		PF01596
(Methyltransf_3) 		4 SER A  68
ARG A  71
LEU A  50
ALA A  75
 None
 0.96A 3ns1L-2gpyA:
undetectable		 3ns1L-2gpyA:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gu0 NONSTRUCTURAL
PROTEIN 2

(Rotavirus C) 		PF02509
(Rota_NS35) 		4 SER A 285
THR A 268
LEU A 273
ALA A 235
 None
 1.01A 3ns1L-2gu0A:
undetectable		 3ns1L-2gu0A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hjs USG-1 PROTEIN
HOMOLOG

(Pseudomonas
aeruginosa) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 SER A  42
THR A  13
ALA A  75
ALA A  74
 None
DIO  A 406 (-4.5A)
None
None
 0.90A 3ns1L-2hjsA:
undetectable		 3ns1L-2hjsA:
19.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hp3 IDS-EPIMERASE

(Agrobacterium
tumefaciens) 		PF03972
(MmgE_PrpD) 		4 SER A 212
THR A 161
ALA A  77
ALA A 107
 None
 0.94A 3ns1L-2hp3A:
undetectable		 3ns1L-2hp3A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6b ADENOSINE KINASE

(Homo sapiens) 		PF00294
(PfkB) 		4 PHE A 302
LEU A 285
ALA A 326
ALA A 327
 None
 0.95A 3ns1L-2i6bA:
undetectable		 3ns1L-2i6bA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 SER A  30
LEU A  75
ALA A 455
ALA A 456
 None
 0.91A 3ns1L-2ivdA:
undetectable		 3ns1L-2ivdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 SER A  64
ARG A 354
PHE A 351
ALA A 347
 FAD  A1466 (-4.4A)
None
None
None
 0.99A 3ns1L-2ivdA:
undetectable		 3ns1L-2ivdA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jok PUTATIVE
G-NUCLEOTIDE
EXCHANGE FACTOR

(Burkholderia
pseudomallei) 		PF07487
(SopE_GEF) 		4 THR A 179
LEU A 177
ALA A 117
ALA A 121
 None
 0.89A 3ns1L-2jokA:
undetectable		 3ns1L-2jokA:
14.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m4n PROTEIN AFD-1,
ISOFORM A

(Caenorhabditis
elegans) 		PF00788
(RA) 		4 ARG A  33
LEU A   7
ALA A  38
ALA A  37
 None
 0.98A 3ns1L-2m4nA:
undetectable		 3ns1L-2m4nA:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oga TRANSAMINASE

(Streptomyces
venezuelae) 		PF01041
(DegT_DnrJ_EryC1) 		4 SER A  36
ARG A  32
ALA A 243
ALA A 244
 None
 0.93A 3ns1L-2ogaA:
undetectable		 3ns1L-2ogaA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rf7 CYTOCHROME C-552

(Escherichia
coli) 		PF02335
(Cytochrom_C552) 		4 SER A 253
LEU A 446
ALA A 440
ALA A 443
 None
 0.98A 3ns1L-2rf7A:
undetectable		 3ns1L-2rf7A:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uxt PROTEIN SUFI

(Escherichia
coli) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLU A 280
SER A 168
PHE A 261
LEU A 162
 None
 0.93A 3ns1L-2uxtA:
undetectable		 3ns1L-2uxtA:
19.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 ARG B 310
PHE B 344
THR B 460
LEU B 464
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
None
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.42A 3ns1L-2w55B:
48.9		 3ns1L-2w55B:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A 322
LEU A 382
ALA A 310
ALA A 338
 None
 1.00A 3ns1L-2wgeA:
undetectable		 3ns1L-2wgeA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		5 ARG C 306
THR C 159
LEU C  55
ALA C 152
ALA C  59
 None
 1.48A 3ns1L-2wy0C:
undetectable		 3ns1L-2wy0C:
22.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xax RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE 1
SUBUNIT ALPHA

(Escherichia
coli) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC)
PF03477
(ATP-cone) 		4 GLU A 458
SER A 614
THR A 571
ALA A 431
 None
 0.93A 3ns1L-2xaxA:
undetectable		 3ns1L-2xaxA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xlr FLAVIN-CONTAINING
MONOOXYGENASE

(Methylophaga
aminisulfidivorans) 		PF00743
(FMO-like) 		4 GLU A  82
SER A  77
ALA A 430
ALA A 100
 None
FAD  A 500 (-4.4A)
None
None
 0.99A 3ns1L-2xlrA:
undetectable		 3ns1L-2xlrA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yva DNAA
INITIATOR-ASSOCIATIN
G PROTEIN DIAA

(Escherichia
coli) 		PF13580
(SIS_2) 		4 SER A  12
LEU A 177
ALA A  20
ALA A  19
 None
 0.71A 3ns1L-2yvaA:
undetectable		 3ns1L-2yvaA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		4 ARG A 169
LEU A 158
ALA A 139
ALA A 142
 None
 1.01A 3ns1L-2yysA:
undetectable		 3ns1L-2yysA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zci PHOSPHOENOLPYRUVATE
CARBOXYKINASE [GTP]

(Corynebacterium
glutamicum) 		PF00821
(PEPCK_C)
PF17297
(PEPCK_N) 		4 GLU A 357
SER A 379
LEU A 367
ALA A 384
 None
 0.91A 3ns1L-2zciA:
undetectable		 3ns1L-2zciA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zm5 TRNA
DELTA(2)-ISOPENTENYL
PYROPHOSPHATE
TRANSFERASE

(Escherichia
coli) 		PF01715
(IPPT) 		4 THR A 181
LEU A 172
ALA A 157
ALA A 156
 None
 0.98A 3ns1L-2zm5A:
undetectable		 3ns1L-2zm5A:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3i PENICILLIN-BINDING
PROTEIN 4

(Haemophilus
influenzae) 		PF02113
(Peptidase_S13) 		4 SER A 310
THR A 401
ALA A 431
ALA A 419
 AIX  A 501 (-2.8A)
AIX  A 501 ( 4.0A)
None
None
 0.94A 3ns1L-3a3iA:
undetectable		 3ns1L-3a3iA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 ARG A 173
THR A 152
LEU A 140
ALA A 149
 None
 0.88A 3ns1L-3a9xA:
undetectable		 3ns1L-3a9xA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b9g IAG-NUCLEOSIDE
HYDROLASE

(Trypanosoma
vivax) 		PF01156
(IU_nuc_hydro) 		4 GLU A 116
LEU A  35
ALA A  72
ALA A  73
 None
 0.97A 3ns1L-3b9gA:
undetectable		 3ns1L-3b9gA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.95A 3ns1L-3dwoX:
undetectable		 3ns1L-3dwoX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eo7 PUTATIVE
NITROREDUCTASE

(Trichormus
variabilis) 		PF00881
(Nitroreductase) 		4 THR A 345
LEU A 391
ALA A 432
ALA A 431
 ACT  A 709 ( 4.9A)
ACT  A 713 (-4.8A)
None
None
 0.98A 3ns1L-3eo7A:
undetectable		 3ns1L-3eo7A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evz METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF05175
(MTS) 		4 SER A 239
PHE A 230
THR A  76
LEU A  74
 None
 0.97A 3ns1L-3evzA:
undetectable		 3ns1L-3evzA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fyq CG6831-PA (TALIN)

(Drosophila
melanogaster) 		no annotation 4 SER A2111
THR A1984
ALA A2056
ALA A2057
 None
 0.92A 3ns1L-3fyqA:
undetectable		 3ns1L-3fyqA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvc PROBABLE SHORT-CHAIN
TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		4 SER A 200
THR A 189
ALA A 145
ALA A 146
 None
 0.96A 3ns1L-3gvcA:
undetectable		 3ns1L-3gvcA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG C 185
LEU C 152
ALA C 161
ALA C 162
 None
 0.99A 3ns1L-3gzdC:
undetectable		 3ns1L-3gzdC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ARG C 185
THR C 164
LEU C 152
ALA C 161
 None
 0.87A 3ns1L-3gzdC:
undetectable		 3ns1L-3gzdC:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hdx SUSD SUPERFAMILY
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 SER A 232
LEU A 151
ALA A 146
ALA A 200
 EDO  A 608 ( 4.1A)
None
None
None
 1.00A 3ns1L-3hdxA:
undetectable		 3ns1L-3hdxA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis) 		PF00326
(Peptidase_S9) 		4 SER A 207
THR A 155
ALA A 133
ALA A 134
 None
 1.01A 3ns1L-3hxkA:
undetectable		 3ns1L-3hxkA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihg RDME

(Streptomyces
purpurascens) 		PF01494
(FAD_binding_3) 		4 THR A 524
LEU A 529
ALA A 463
ALA A 462
 None
 0.98A 3ns1L-3ihgA:
1.1		 3ns1L-3ihgA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 4 SER A 585
THR A 256
ALA A 262
ALA A 261
 None
 0.76A 3ns1L-3j3iA:
undetectable		 3ns1L-3j3iA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jq0 SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 472
SER A 350
PHE A 260
ALA A 424
 None
 0.90A 3ns1L-3jq0A:
undetectable		 3ns1L-3jq0A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jr7 UNCHARACTERIZED EGV
FAMILY PROTEIN
COG1307

([Ruminococcus]
gnavus) 		PF02645
(DegV) 		4 GLU A  31
SER A 138
THR A 176
ALA A 252
 None
PG6  A 299 ( 4.7A)
PG6  A 299 ( 4.2A)
None
 0.99A 3ns1L-3jr7A:
undetectable		 3ns1L-3jr7A:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jtm FORMATE
DEHYDROGENASE,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 SER A 124
LEU A 373
ALA A 131
ALA A 132
 GOL  A 383 (-2.7A)
None
None
None
 0.98A 3ns1L-3jtmA:
undetectable		 3ns1L-3jtmA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kvo HYDROXYSTEROID
DEHYDROGENASE-LIKE
PROTEIN 2

(Homo sapiens) 		PF00106
(adh_short) 		4 SER A  19
LEU A  50
ALA A 205
ALA A 204
 NAP  A 501 (-2.7A)
None
NAP  A 501 (-3.3A)
None
 0.94A 3ns1L-3kvoA:
undetectable		 3ns1L-3kvoA:
18.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1t PUTATIVE
PHOSPHOHYDROLASE

(Shewanella
amazonensis) 		PF08668
(HDOD) 		4 SER A 138
THR A 109
ALA A 225
ALA A 224
 None
 0.85A 3ns1L-3m1tA:
undetectable		 3ns1L-3m1tA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.82A 3ns1L-3mc2A:
undetectable		 3ns1L-3mc2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndc PRECORRIN-4
C(11)-METHYLTRANSFER
ASE

(Rhodobacter
capsulatus) 		PF00590
(TP_methylase) 		4 THR A 219
LEU A 221
ALA A 115
ALA A 193
 SAH  A 300 (-4.3A)
SAH  A 300 (-4.4A)
None
SAH  A 300 (-3.4A)
 0.95A 3ns1L-3ndcA:
undetectable		 3ns1L-3ndcA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nfv ALGINATE LYASE

(Bacteroides
ovatus) 		PF05426
(Alginate_lyase) 		4 THR A 321
LEU A 273
ALA A 331
ALA A 330
 EDO  A 415 (-4.9A)
None
None
EDO  A 405 ( 3.7A)
 0.86A 3ns1L-3nfvA:
undetectable		 3ns1L-3nfvA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o2k BREVIANAMIDE F
PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		4 THR A 188
LEU A 285
ALA A 143
ALA A 142
 None
 0.86A 3ns1L-3o2kA:
0.2		 3ns1L-3o2kA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE

(Mycolicibacterium
smegmatis) 		PF01182
(Glucosamine_iso) 		4 SER A 201
THR A  46
ALA A  18
ALA A  19
 None
 0.67A 3ns1L-3oc6A:
1.3		 3ns1L-3oc6A:
16.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opb SWI5-DEPENDENT HO
EXPRESSION PROTEIN 4

(Saccharomyces
cerevisiae) 		PF11701
(UNC45-central) 		4 SER A 368
ARG A 367
ALA A 435
ALA A 436
 None
 1.00A 3ns1L-3opbA:
undetectable		 3ns1L-3opbA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oyr TRANS-ISOPRENYL
DIPHOSPHATE SYNTHASE

(Caulobacter
vibrioides) 		PF00348
(polyprenyl_synt) 		4 SER A 258
ARG A 257
LEU A 251
ALA A 292
 None
 0.96A 3ns1L-3oyrA:
1.1		 3ns1L-3oyrA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pdx TYROSINE
AMINOTRANSFERASE

(Mus musculus) 		PF00155
(Aminotran_1_2) 		4 THR A 334
LEU A 331
ALA A 326
ALA A  96
 None
 0.95A 3ns1L-3pdxA:
undetectable		 3ns1L-3pdxA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rx8 CELLULASE

(Alicyclobacillus
acidocaldarius) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N) 		4 ARG A 275
THR A 320
LEU A 257
ALA A 271
 None
 1.00A 3ns1L-3rx8A:
undetectable		 3ns1L-3rx8A:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3t NUCLEOTIDE-BINDING
PROTEIN, UNIVERSAL
STRESS PROTEIN USPA
FAMILY

(Lactobacillus
plantarum) 		PF00582
(Usp) 		4 ARG A   4
LEU A 111
ALA A  29
ALA A  34
 None
 0.96A 3ns1L-3s3tA:
undetectable		 3ns1L-3s3tA:
11.50
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		8 GLU C 802
SER C 876
ARG C 880
PHE C 914
THR C1010
LEU C1014
ALA C1078
ALA C1079
 RMO  C1317 (-4.4A)
None
None
RMO  C1317 (-3.6A)
None
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
 0.23A 3ns1L-3sr6C:
57.6		 3ns1L-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swg UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF00275
(EPSP_synthase) 		4 SER A 125
THR A 374
LEU A 376
ALA A 378
 QPA  A 124 ( 3.3A)
None
EPZ  A 518 (-4.4A)
None
 1.00A 3ns1L-3swgA:
undetectable		 3ns1L-3swgA:
23.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thz DNA MISMATCH REPAIR
PROTEIN MSH2

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 ARG A 308
LEU A 302
ALA A 710
ALA A 305
 None
 0.85A 3ns1L-3thzA:
undetectable		 3ns1L-3thzA:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tkt CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		4 SER A 255
THR A 259
LEU A 115
ALA A 247
 None
 0.86A 3ns1L-3tktA:
undetectable		 3ns1L-3tktA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tx2 PROBABLE
6-PHOSPHOGLUCONOLACT
ONASE

(Mycobacteroides
abscessus) 		PF01182
(Glucosamine_iso) 		4 SER A 203
THR A  46
ALA A  18
ALA A  19
 None
 0.74A 3ns1L-3tx2A:
undetectable		 3ns1L-3tx2A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v71 PUF (PUMILIO/FBF)
DOMAIN-CONTAINING
PROTEIN 7, CONFIRMED
BY TRANSCRIPT
EVIDENCE

(Caenorhabditis
elegans) 		PF00806
(PUF) 		4 PHE A 348
LEU A 328
ALA A 351
ALA A 347
 None
 0.91A 3ns1L-3v71A:
undetectable		 3ns1L-3v71A:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 0.98A 3ns1L-3v7nA:
undetectable		 3ns1L-3v7nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 SER A 105
THR A  86
ALA A 146
ALA A 152
 None
 0.95A 3ns1L-3wczA:
undetectable		 3ns1L-3wczA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wcz ALDO-KETO REDUCTASE
2E

(Bombyx mori) 		PF00248
(Aldo_ket_red) 		4 SER A 105
THR A  86
LEU A  88
ALA A 146
 None
 0.97A 3ns1L-3wczA:
undetectable		 3ns1L-3wczA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxr PROTEASOME SUBUNIT
BETA TYPE-5

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome) 		4 SER L  18
ARG L  19
ALA L 164
ALA L 165
 None
 1.00A 3ns1L-3wxrL:
undetectable		 3ns1L-3wxrL:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bc5 XYLULOSE KINASE

(Homo sapiens) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 PHE A 478
LEU A  11
ALA A  91
ALA A 477
 None
 0.97A 3ns1L-4bc5A:
undetectable		 3ns1L-4bc5A:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 SER A 488
ARG A 487
LEU A 471
ALA A 475
 None
 0.97A 3ns1L-4c7gA:
undetectable		 3ns1L-4c7gA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cns DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.46A 3ns1L-4cnsA:
undetectable		 3ns1L-4cnsA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		5 GLU A 232
SER A 308
THR A 313
ALA A 260
ALA A 261
 None
 1.41A 3ns1L-4cntA:
undetectable		 3ns1L-4cntA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyf PANTETHEINASE

(Homo sapiens) 		PF00795
(CN_hydrolase) 		4 SER A 265
LEU A  60
ALA A  34
ALA A  33
 None
 1.00A 3ns1L-4cyfA:
undetectable		 3ns1L-4cyfA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d3y LEGUMAIN

(Cricetulus
griseus) 		PF01650
(Peptidase_C13) 		4 GLU A 192
SER A 312
ALA A 214
ALA A 215
 None
CSX  A 194 ( 3.8A)
None
CSX  A 194 ( 4.6A)
 0.84A 3ns1L-4d3yA:
undetectable		 3ns1L-4d3yA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dx3 MANDELATE RACEMASE /
MUCONATE LACTONIZING
ENZYME FAMILY
PROTEIN

(Agrobacterium
fabrum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 SER A 251
THR A 282
ALA A 258
ALA A 257
 None
 0.81A 3ns1L-4dx3A:
undetectable		 3ns1L-4dx3A:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgu LEGUMAIN

(Homo sapiens) 		PF01650
(Peptidase_C13) 		4 GLU A 187
SER A 307
ALA A 209
ALA A 210
 None
 0.91A 3ns1L-4fguA:
undetectable		 3ns1L-4fguA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 GLU A 103
THR A  74
ALA A 107
ALA A 110
 None
 0.93A 3ns1L-4g2rA:
undetectable		 3ns1L-4g2rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gpg PROTEASE 1

(Achromobacter
lyticus) 		PF00089
(Trypsin) 		4 SER A 112
ARG A 229
THR A 232
LEU A 244
 None
 0.95A 3ns1L-4gpgA:
undetectable		 3ns1L-4gpgA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		4 GLU A 180
ARG A 141
ALA A 177
ALA A 140
 None
 0.99A 3ns1L-4infA:
undetectable		 3ns1L-4infA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 ARG A 344
THR A 357
ALA A 349
ALA A 348
 None
 0.92A 3ns1L-4j1sA:
0.6		 3ns1L-4j1sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxk OXIDOREDUCTASE

(Rhodococcus
opacus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 THR A 190
LEU A 192
ALA A 157
ALA A 178
 None
 1.01A 3ns1L-4jxkA:
undetectable		 3ns1L-4jxkA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7t NANU SIALIC ACID
BINDING PROTEIN

(Bacteroides
fragilis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 GLU A 463
SER A 343
PHE A 253
ALA A 417
 None
 0.87A 3ns1L-4l7tA:
undetectable		 3ns1L-4l7tA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mes THIAMINE TRANSPORTER
THIT

(Lactococcus
lactis) 		PF09515
(Thia_YuaJ) 		4 GLU A  38
LEU A  92
ALA A  40
ALA A  21
 26G  A 203 (-3.8A)
None
None
None
 0.98A 3ns1L-4mesA:
undetectable		 3ns1L-4mesA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mmo SSO-CP2
METALLO-CARBOXYPETID
ASE

(Sulfolobus
solfataricus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 THR A  34
LEU A  39
ALA A  56
ALA A  43
 None
 0.86A 3ns1L-4mmoA:
1.1		 3ns1L-4mmoA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mud RING OXYDATION
COMPLEX/
PHENYLACETIC ACID
DEGRADATION RELATED
PROTEIN

(Sulfolobus
solfataricus) 		PF05138
(PaaA_PaaC) 		4 SER A 149
THR A 109
LEU A 111
ALA A 165
 None
 0.85A 3ns1L-4mudA:
undetectable		 3ns1L-4mudA:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my0 GCN5-RELATED
N-ACETYLTRANSFERASE

(Kribbella
flavida) 		PF13527
(Acetyltransf_9)
PF13530
(SCP2_2) 		4 SER A 342
LEU A 282
ALA A 287
ALA A 284
 None
 0.97A 3ns1L-4my0A:
undetectable		 3ns1L-4my0A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nfu SENESCENCE-ASSOCIATE
D CARBOXYLESTERASE
101

(Arabidopsis
thaliana) 		PF01764
(Lipase_3) 		4 SER B  25
PHE B 175
THR B 143
LEU B 171
 None
 1.01A 3ns1L-4nfuB:
undetectable		 3ns1L-4nfuB:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 ARG A 131
LEU A 458
ALA A 465
ALA A 466
 None
 0.92A 3ns1L-4nleA:
undetectable		 3ns1L-4nleA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nsy LYSYL ENDOPEPTIDASE

(Lysobacter
enzymogenes) 		PF13365
(Trypsin_2) 		4 SER A 112
ARG A 229
THR A 232
LEU A 244
 None
 0.91A 3ns1L-4nsyA:
undetectable		 3ns1L-4nsyA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4omg GERANYLGERANYL
DIPHOSPHATE CYCLASE

(Streptomyces
melanosporofaciens) 		no annotation 4 SER A 190
LEU A 281
ALA A 209
ALA A 208
 None
 0.82A 3ns1L-4omgA:
undetectable		 3ns1L-4omgA:
16.27