SIMILAR PATTERNS OF AMINO ACIDS FOR 3NS1_C_PM6C1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a9x CARBAMOYL PHOSPHATE
SYNTHETASE (SMALL
CHAIN)

(Escherichia
coli) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain) 		4 ARG B1712
PHE B1867
ALA B1863
ALA B1864
 None
 0.86A 3ns1C-1a9xB:
0.0		 3ns1C-1a9xB:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf6 PHOSPHOTRIESTERASE
HOMOLOGY PROTEIN

(Escherichia
coli) 		PF02126
(PTE) 		4 GLU A 108
THR A  55
ALA A 120
ALA A  79
 None
 1.13A 3ns1C-1bf6A:
0.1		 3ns1C-1bf6A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		4 GLU A 218
ARG A 222
ALA A 139
ALA A 140
 None
 1.17A 3ns1C-1cbfA:
0.0		 3ns1C-1cbfA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e08 [FE]-HYDROGENASE
(LARGE SUBUNIT)

(Desulfovibrio
desulfuricans) 		PF02906
(Fe_hyd_lg_C)
PF13187
(Fer4_9) 		4 GLU A 156
PHE A 296
ALA A 306
ALA A 305
 None
CYN  A   7 ( 4.2A)
None
None
 0.93A 3ns1C-1e08A:
undetectable		 3ns1C-1e08A:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g8x MYOSIN II HEAVY
CHAIN FUSED TO
ALPHA-ACTININ 3

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		4 GLU A 292
PHE A 345
THR A 327
ALA A 288
 None
 1.18A 3ns1C-1g8xA:
0.0		 3ns1C-1g8xA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 ARG P 283
THR P 103
ALA P 285
ALA P 284
 None
 1.17A 3ns1C-1hynP:
undetectable		 3ns1C-1hynP:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcx DIHYDROPYRIMIDINASE
RELATED PROTEIN-1

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.18A 3ns1C-1kcxA:
undetectable		 3ns1C-1kcxA:
21.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 802
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 TEI  A3006 ( 3.2A)
TEI  A3006 (-3.5A)
TEI  A3006 (-3.6A)
TEI  A3006 (-2.8A)
MOS  A3004 (-3.0A)
TEI  A3006 ( 3.8A)
 0.35A 3ns1C-1n5xA:
60.7		 3ns1C-1n5xA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nzy 4-CHLOROBENZOYL
COENZYME A
DEHALOGENASE

(Pseudomonas sp.
CBS3) 		PF00378
(ECH_1) 		4 ARG B 192
PHE B 191
THR B  54
ALA B 131
 PO4  B 902 (-4.2A)
None
None
None
 0.72A 3ns1C-1nzyB:
0.0		 3ns1C-1nzyB:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE

(Geobacillus
stearothermophilus) 		PF06964
(Alpha-L-AF_C) 		4 GLU A 227
ARG A 218
PHE A 267
ALA A 224
 None
 1.17A 3ns1C-1pz3A:
undetectable		 3ns1C-1pz3A:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub3 ALDOLASE PROTEIN

(Thermus
thermophilus) 		PF01791
(DeoC) 		4 GLU A  27
PHE A  33
THR A 204
ALA A  24
 None
None
HPD  A 801 (-4.4A)
None
 1.22A 3ns1C-1ub3A:
undetectable		 3ns1C-1ub3A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ARG A 209
THR A 138
ALA A 204
ALA A 205
 None
 1.15A 3ns1C-1v9pA:
undetectable		 3ns1C-1v9pA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vb3 THREONINE SYNTHASE

(Escherichia
coli) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 106
THR A 137
ALA A 377
ALA A 105
 None
KPA  A 500 (-2.9A)
None
None
 0.85A 3ns1C-1vb3A:
undetectable		 3ns1C-1vb3A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vz8 ORNITHINE
ACETYL-TRANSFERASE

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLU A 155
ARG A 141
ALA A 143
ALA A 142
 None
 1.04A 3ns1C-1vz8A:
3.6		 3ns1C-1vz8A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		4 GLU A   5
THR A 148
ALA A  58
ALA A  92
 None
 0.99A 3ns1C-2bdqA:
undetectable		 3ns1C-2bdqA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cve HYPOTHETICAL PROTEIN
TTHA1053

(Thermus
thermophilus) 		PF01205
(UPF0029)
PF09186
(DUF1949) 		4 GLU A 191
THR A 156
ALA A 131
ALA A 165
 None
 1.11A 3ns1C-2cveA:
undetectable		 3ns1C-2cveA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		4 GLU A 104
THR A  45
ALA A 144
ALA A 143
 None
 1.20A 3ns1C-2f96A:
undetectable		 3ns1C-2f96A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f96 RIBONUCLEASE T

(Pseudomonas
aeruginosa) 		PF00929
(RNase_T) 		4 PHE A 140
THR A  45
ALA A 144
ALA A 143
 None
 1.25A 3ns1C-2f96A:
undetectable		 3ns1C-2f96A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		4 GLU A1541
ARG A1509
ALA A1542
ALA A1545
 None
 1.19A 3ns1C-2fr1A:
undetectable		 3ns1C-2fr1A:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		4 GLU A 225
THR A 306
ALA A 253
ALA A 254
 None
 1.18A 3ns1C-2ftwA:
undetectable		 3ns1C-2ftwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzk TRAP-T FAMILY
SORBITOL/MANNITOL
TRANSPORTER,
PERIPLASMIC BINDING
PROTEIN, SMOM

(Rhodobacter
sphaeroides) 		PF03480
(DctP) 		4 GLU A 240
THR A  96
ALA A 113
ALA A 112
 GOL  A 801 (-3.8A)
None
None
None
 1.03A 3ns1C-2hzkA:
undetectable		 3ns1C-2hzkA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2icy PROBABLE
UTP-GLUCOSE-1-PHOSPH
ATE
URIDYLYLTRANSFERASE
2

(Arabidopsis
thaliana) 		PF01704
(UDPGP) 		4 GLU A 316
PHE A 342
ALA A 338
ALA A 339
 None
 1.24A 3ns1C-2icyA:
undetectable		 3ns1C-2icyA:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is3 RIBONUCLEASE T

(Escherichia
coli) 		PF00929
(RNase_T) 		4 PHE A 128
THR A  33
ALA A 132
ALA A 131
 None
 1.22A 3ns1C-2is3A:
undetectable		 3ns1C-2is3A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kgy POSSIBLE EXPORTED
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 ARG A  43
THR A  35
ALA A  45
ALA A  44
 None
 0.78A 3ns1C-2kgyA:
undetectable		 3ns1C-2kgyA:
8.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzw ELONGATION FACTOR G

(Staphylococcus
aureus) 		PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 GLU A 610
ARG A 665
THR A 662
ALA A 639
 None
 1.17A 3ns1C-2mzwA:
undetectable		 3ns1C-2mzwA:
17.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2n1b GTP-BINDING NUCLEAR
PROTEIN RAN

(Homo sapiens) 		PF00071
(Ras) 		4 GLU A   6
ARG A  56
ALA A   3
ALA A   2
 None
 1.04A 3ns1C-2n1bA:
undetectable		 3ns1C-2n1bA:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ob5 HYPOTHETICAL PROTEIN
ATU2016

(Agrobacterium
fabrum) 		PF05025
(RbsD_FucU) 		4 GLU A  94
THR A 133
ALA A  56
ALA A  55
 None
 1.14A 3ns1C-2ob5A:
undetectable		 3ns1C-2ob5A:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oce HYPOTHETICAL PROTEIN
PA5201

(Pseudomonas
aeruginosa) 		PF00575
(S1)
PF09371
(Tex_N)
PF12836
(HHH_3)
PF16921
(Tex_YqgF) 		4 PHE A 557
THR A  37
ALA A 555
ALA A 554
 None
 1.21A 3ns1C-2oceA:
undetectable		 3ns1C-2oceA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE

(Neisseria
gonorrhoeae) 		PF00583
(Acetyltransf_1)
PF00696
(AA_kinase) 		4 GLU A 327
ARG A 416
ALA A 342
ALA A 355
 None
 1.14A 3ns1C-2r98A:
undetectable		 3ns1C-2r98A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ra5 PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00392
(GntR)
PF07702
(UTRA) 		4 ARG A 190
THR A 210
ALA A 206
ALA A 192
 None
 1.17A 3ns1C-2ra5A:
undetectable		 3ns1C-2ra5A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfz CELLULOSE
1,4-BETA-CELLOBIOSID
ASE

(Melanocarpus
albomyces) 		PF00840
(Glyco_hydro_7) 		4 GLU A 212
THR A 246
ALA A 174
ALA A 258
 CTR  A 431 (-3.3A)
CTR  A 431 (-4.2A)
None
None
 1.23A 3ns1C-2rfzA:
undetectable		 3ns1C-2rfzA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4i GLUTAMATE
N-ACETYLTRANSFERASE
2 ALPHA CHAIN

(Streptomyces
clavuligerus) 		PF01960
(ArgJ) 		4 GLU A 155
ARG A 141
ALA A 143
ALA A 142
 None
 1.06A 3ns1C-2v4iA:
3.5		 3ns1C-2v4iA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vbf BRANCHED-CHAIN
ALPHA-KETOACID
DECARBOXYLASE

(Lactococcus
lactis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLU A 156
ARG A 148
ALA A 132
ALA A 133
 GLU  A 156 ( 0.6A)
ARG  A 148 ( 0.6A)
ALA  A 132 ( 0.0A)
ALA  A 133 ( 0.0A)
 1.09A 3ns1C-2vbfA:
undetectable		 3ns1C-2vbfA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr2 DIHYDROPYRIMIDINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLU A 226
THR A 307
ALA A 254
ALA A 255
 None
 1.16A 3ns1C-2vr2A:
undetectable		 3ns1C-2vr2A:
21.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2w55 XANTHINE
DEHYDROGENASE

(Rhodobacter
capsulatus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 ARG B 310
PHE B 344
THR B 460
ALA B 528
ALA B 529
 HPA  B1780 (-3.4A)
HPA  B1780 (-3.4A)
HPA  B1780 (-3.6A)
XAX  B1778 ( 3.2A)
HPA  B1780 ( 3.2A)
 0.44A 3ns1C-2w55B:
55.5		 3ns1C-2w55B:
40.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans) 		PF14520
(HHH_5)
PF14716
(HHH_8) 		4 GLU A  86
THR A  20
ALA A  89
ALA A  88
 None
 1.26A 3ns1C-2w9mA:
undetectable		 3ns1C-2w9mA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfk ASPARTATE/ORNITHINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 PHE A 373
THR A  44
ALA A 369
ALA A 370
 None
 1.17A 3ns1C-2yfkA:
undetectable		 3ns1C-2yfkA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjn DTDP-4-KETO-6-DEOXY-
HEXOSE 3,4-ISOMERASE

(Saccharopolyspora
erythraea) 		PF00067
(p450) 		4 ARG B 273
THR B 102
ALA B 129
ALA B 128
 None
 1.24A 3ns1C-2yjnB:
undetectable		 3ns1C-2yjnB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zy2 L-ASPARTATE
4-CARBOXYLYASE

(Pseudomonas sp.
ATCC 19121) 		PF00155
(Aminotran_1_2) 		4 GLU A 172
PHE A 169
ALA A 176
ALA A 177
 None
 1.22A 3ns1C-2zy2A:
undetectable		 3ns1C-2zy2A:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3u MENAQUINONE
BIOSYNTHETIC ENZYME

(Thermus
thermophilus) 		PF02621
(VitK2_biosynth) 		4 PHE A 254
THR A 107
ALA A 263
ALA A 257
 None
TLA  A 401 (-3.9A)
None
None
 1.06A 3ns1C-3a3uA:
undetectable		 3ns1C-3a3uA:
17.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aib GLUCOSYLTRANSFERASE-
SI

(Streptococcus
mutans) 		PF02324
(Glyco_hydro_70) 		4 PHE A 259
THR A1078
ALA A 257
ALA A 256
 None
 1.23A 3ns1C-3aibA:
undetectable		 3ns1C-3aibA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3att PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
tuberculosis) 		PF01636
(APH) 		4 GLU A 277
THR A 198
ALA A 238
ALA A 239
 None
 1.12A 3ns1C-3attA:
undetectable		 3ns1C-3attA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d8k PROTEIN PHOSPHATASE
2C

(Toxoplasma
gondii) 		PF00481
(PP2C) 		4 ARG A 172
PHE A 308
ALA A 174
ALA A 173
 None
 1.13A 3ns1C-3d8kA:
undetectable		 3ns1C-3d8kA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwo PROBABLE OUTER
MEMBRANE PROTEIN

(Pseudomonas
aeruginosa) 		PF03349
(Toluene_X) 		4 PHE X  39
THR X 227
ALA X  35
ALA X  36
 None
 0.96A 3ns1C-3dwoX:
undetectable		 3ns1C-3dwoX:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsx TETRAHYDRODIPICOLINA
TE
N-SUCCINYLTRANSFERAS
E

(Mycobacterium
tuberculosis) 		PF14602
(Hexapep_2)
PF14789
(THDPS_M) 		4 PHE A  26
THR A  39
ALA A   7
ALA A   8
 None
 1.20A 3ns1C-3fsxA:
undetectable		 3ns1C-3fsxA:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gmi UPF0348 PROTEIN
MJ0951

(Methanocaldococcus
jannaschii) 		PF05636
(HIGH_NTase1)
PF16581
(HIGH_NTase1_ass) 		4 PHE A  79
THR A  57
ALA A 110
ALA A 107
 None
 1.14A 3ns1C-3gmiA:
undetectable		 3ns1C-3gmiA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jzj ACARBOSE/MALTOSE
BINDING PROTEIN GACH

(Streptomyces
glaucescens) 		PF13416
(SBP_bac_8) 		4 GLU A 357
THR A 329
ALA A 117
ALA A 116
 None
 1.25A 3ns1C-3jzjA:
1.0		 3ns1C-3jzjA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kst ENDO-1,4-BETA-XYLANA
SE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		4 ARG A  87
THR A  69
ALA A  91
ALA A  75
 None
 1.23A 3ns1C-3kstA:
undetectable		 3ns1C-3kstA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc2 INHIBITOR OF
CARBONIC ANHYDRASE

(Mus musculus) 		PF00405
(Transferrin) 		4 GLU A  83
THR A 209
ALA A 299
ALA A 298
 None
 0.81A 3ns1C-3mc2A:
undetectable		 3ns1C-3mc2A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mde MEDIUM CHAIN
ACYL-COA
DEHYDROGENASE

(Sus scrofa) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 ARG A  44
THR A 358
ALA A  39
ALA A  40
 None
 1.09A 3ns1C-3mdeA:
undetectable		 3ns1C-3mdeA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3prl NADP-DEPENDENT
GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE

(Bacillus
halodurans) 		PF00171
(Aldedh) 		4 ARG A 446
THR A 238
ALA A 170
ALA A 171
 None
 1.15A 3ns1C-3prlA:
undetectable		 3ns1C-3prlA:
21.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3sr6 XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		6 GLU C 802
ARG C 880
PHE C 914
THR C1010
ALA C1078
ALA C1079
 RMO  C1317 (-4.4A)
None
RMO  C1317 (-3.6A)
None
RMO  C1317 (-3.2A)
RMO  C1317 ( 3.6A)
 0.25A 3ns1C-3sr6C:
67.2		 3ns1C-3sr6C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uss PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		PF05995
(CDO_I) 		4 GLU A 127
ARG A 123
ALA A 103
ALA A 147
 None
SO4  A 216 (-3.8A)
None
None
 1.19A 3ns1C-3ussA:
undetectable		 3ns1C-3ussA:
13.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7n THREONINE SYNTHASE

(Burkholderia
thailandensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 125
THR A 158
ALA A 430
ALA A 124
 None
MLA  A 484 ( 3.4A)
None
None
 0.97A 3ns1C-3v7nA:
undetectable		 3ns1C-3v7nA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wkh CELLOBIOSE
2-EPIMERASE

(Rhodothermus
marinus) 		PF07221
(GlcNAc_2-epim) 		4 GLU A  56
ARG A 115
ALA A 112
ALA A 111
 None
 1.15A 3ns1C-3wkhA:
undetectable		 3ns1C-3wkhA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wo4 INTERLEUKIN-18
RECEPTOR 1

(Homo sapiens) 		no annotation 4 GLU B 266
THR B 299
ALA B 278
ALA B 239
 None
 1.25A 3ns1C-3wo4B:
undetectable		 3ns1C-3wo4B:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cnt DIHYDROPYRIMIDINASE-
LIKE 3

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.21A 3ns1C-4cntA:
undetectable		 3ns1C-4cntA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cv5 GENERAL NEGATIVE
REGULATOR OF
TRANSCRIPTION
SUBUNIT 1

(Saccharomyces
cerevisiae) 		PF12842
(DUF3819) 		4 GLU A1268
THR A1120
ALA A1139
ALA A1140
 None
 1.12A 3ns1C-4cv5A:
undetectable		 3ns1C-4cv5A:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dg8 PA1221

(Pseudomonas
aeruginosa) 		PF00501
(AMP-binding) 		4 PHE A 213
THR A 258
ALA A 216
ALA A 215
 BU3  A 703 ( 3.9A)
BU3  A 703 (-3.7A)
None
BU3  A 703 ( 3.8A)
 0.99A 3ns1C-4dg8A:
undetectable		 3ns1C-4dg8A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4f THREONINE SYNTHASE

(Brucella
melitensis) 		PF00291
(PALP)
PF14821
(Thr_synth_N) 		4 PHE A 111
THR A 144
ALA A 410
ALA A 110
 PLP  A 501 (-4.3A)
None
PLP  A 501 (-3.6A)
PLP  A 501 ( 4.9A)
 1.15A 3ns1C-4f4fA:
undetectable		 3ns1C-4f4fA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g2r ACCD6,
CARBOXYLTRANSFERASE
BETA-SUBUNIT OF
ACYL-COA CARBOXYLASE

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 GLU A 103
THR A  74
ALA A 107
ALA A 110
 None
 0.91A 3ns1C-4g2rA:
undetectable		 3ns1C-4g2rA:
23.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4glw DNA LIGASE

(Streptococcus
pneumoniae) 		PF01653
(DNA_ligase_aden) 		4 ARG A 199
THR A 129
ALA A 194
ALA A 195
 None
 1.18A 3ns1C-4glwA:
undetectable		 3ns1C-4glwA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz7 DIHYDROPYRIMIDINASE

(Tetraodon
nigroviridis) 		PF01979
(Amidohydro_1) 		4 GLU A 222
THR A 303
ALA A 250
ALA A 251
 None
 1.23A 3ns1C-4gz7A:
undetectable		 3ns1C-4gz7A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inf METAL-DEPENDENT
HYDROLASE

(Novosphingobium
aromaticivorans) 		PF04909
(Amidohydro_2) 		4 GLU A 180
ARG A 141
ALA A 177
ALA A 140
 None
 0.99A 3ns1C-4infA:
undetectable		 3ns1C-4infA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izd ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Ruegeria
pomeroyi) 		PF00378
(ECH_1) 		4 PHE A 195
THR A  25
ALA A 198
ALA A 110
 None
 1.08A 3ns1C-4izdA:
undetectable		 3ns1C-4izdA:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j1s POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 ARG A 344
THR A 357
ALA A 349
ALA A 348
 None
 0.92A 3ns1C-4j1sA:
undetectable		 3ns1C-4j1sA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k46 ADENYLATE KINASE

(Photobacterium
profundum) 		PF00406
(ADK)
PF05191
(ADK_lid) 		4 ARG A 119
THR A 199
ALA A   8
ALA A  11
 ADP  A 301 (-3.6A)
None
None
ADP  A 301 (-4.2A)
 1.10A 3ns1C-4k46A:
undetectable		 3ns1C-4k46A:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		4 ARG A 283
THR A 103
ALA A 285
ALA A 284
 None
 1.19A 3ns1C-4ky9A:
undetectable		 3ns1C-4ky9A:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLU A 134
THR A 469
ALA A 130
ALA A 127
 None
 1.23A 3ns1C-4nleA:
undetectable		 3ns1C-4nleA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 GLU A2108
THR A1905
ALA A2121
ALA A1898
 None
 1.25A 3ns1C-4o9xA:
undetectable		 3ns1C-4o9xA:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pch VP1

(Human
polyomavirus 7) 		PF00718
(Polyoma_coat) 		4 GLU A 187
THR A  63
ALA A  73
ALA A  72
 None
 1.06A 3ns1C-4pchA:
undetectable		 3ns1C-4pchA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4po6 NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		no annotation 4 PHE A 160
THR A 262
ALA A 165
ALA A 267
 None
 1.23A 3ns1C-4po6A:
undetectable		 3ns1C-4po6A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLU A 582
THR A 480
ALA A 536
ALA A 523
 None
 1.21A 3ns1C-4rvwA:
undetectable		 3ns1C-4rvwA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wcj POLYSACCHARIDE
DEACETYLASE

(Ammonifex
degensii) 		PF01522
(Polysacc_deac_1) 		4 ARG A 261
PHE A 244
THR A 112
ALA A 221
 None
 1.08A 3ns1C-4wcjA:
undetectable		 3ns1C-4wcjA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0q DNA POLYMERASE THETA

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A2335
THR A2237
ALA A2477
ALA A2478
 DG3  A2604 ( 4.4A)
None
None
None
 1.04A 3ns1C-4x0qA:
undetectable		 3ns1C-4x0qA:
22.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgc ORIGIN RECOGNITION
COMPLEX SUBUNIT 3
ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Drosophila
melanogaster) 		PF07034
(ORC3_N)
PF13191
(AAA_16)
PF14630
(ORC5_C) 		4 GLU E 320
PHE C 309
ALA C 270
ALA C 271
 None
 1.13A 3ns1C-4xgcE:
undetectable		 3ns1C-4xgcE:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpd N-TERMINAL
ACETYLTRANSFERASE A
COMPLEX SUBUNIT NAT1

(Saccharomyces
cerevisiae) 		PF12569
(NARP1) 		4 PHE A 383
THR A 386
ALA A 409
ALA A 410
 None
 1.16A 3ns1C-4xpdA:
undetectable		 3ns1C-4xpdA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xvm DNA POLYMERASE NU

(Homo sapiens) 		PF00476
(DNA_pol_A) 		4 GLU A 628
THR A 567
ALA A 772
ALA A 773
 None
 0.93A 3ns1C-4xvmA:
undetectable		 3ns1C-4xvmA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yrp HISTIDYL-TRNA
SYNTHETASE

(Trypanosoma
cruzi) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ARG A 100
THR A 107
ALA A 230
ALA A 317
 None
 1.22A 3ns1C-4yrpA:
undetectable		 3ns1C-4yrpA:
22.28
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		6 GLU A 802
ARG A 880
PHE A 914
THR A1010
ALA A1078
ALA A1079
 URC  A3007 (-3.0A)
URC  A3007 (-3.7A)
URC  A3007 ( 3.4A)
URC  A3007 (-3.5A)
URC  A3007 (-3.5A)
URC  A3007 (-3.4A)
 0.35A 3ns1C-4yswA:
58.8		 3ns1C-4yswA:
59.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzy EUKARYOTIC
TRANSLATION
INITIATION FACTOR
2-ALPHA KINASE 3

(Mus musculus) 		no annotation 4 ARG A 114
THR A 110
ALA A 117
ALA A 116
 None
 1.26A 3ns1C-4yzyA:
undetectable		 3ns1C-4yzyA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zmh UNCHARACTERIZED
PROTEIN

(Saccharophagus
degradans) 		PF15979
(Glyco_hydro_115) 		4 GLU A 824
THR A 948
ALA A 809
ALA A 808
 None
 1.24A 3ns1C-4zmhA:
undetectable		 3ns1C-4zmhA:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aga DNA POLYMERASE THETA

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLU A 830
THR A 861
ALA A 876
ALA A 875
 None
 1.23A 3ns1C-5agaA:
undetectable		 3ns1C-5agaA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 ARG E  60
PHE E  59
ALA E  55
ALA E  56
 None
 1.20A 3ns1C-5brrE:
undetectable		 3ns1C-5brrE:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1m MU-TYPE OPIOID
RECEPTOR

(Mus musculus) 		PF00001
(7tm_1) 		4 PHE A 178
THR A 180
ALA A 168
ALA A 175
 P6G  A 406 (-4.6A)
None
None
None
 1.23A 3ns1C-5c1mA:
undetectable		 3ns1C-5c1mA:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 4 GLU C 302
THR C 183
ALA C 295
ALA C 267
 None
 1.17A 3ns1C-5cw2C:
undetectable		 3ns1C-5cw2C:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ehk LANTIBIOTIC
DEHYDRATASE

(Microbispora
corallina) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ARG A1047
THR A1082
ALA A 933
ALA A 934
 None
 1.23A 3ns1C-5ehkA:
undetectable		 3ns1C-5ehkA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 GLU A2388
ARG A2322
THR A2399
ALA A1428
 None
 1.08A 3ns1C-5h64A:
undetectable		 3ns1C-5h64A:
14.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mm7 -

(-) 		no annotation 4 GLU K  91
ARG K  83
THR K 190
ALA K  88
 ANP  K 501 (-3.5A)
ANP  K 501 (-4.3A)
None
ANP  K 501 ( 4.2A)
 0.87A 3ns1C-5mm7K:
undetectable		 3ns1C-5mm7K:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf2 PROLACTIN REGULATORY
ELEMENT-BINDING
PROTEIN

(Homo sapiens) 		PF00400
(WD40) 		4 PHE A  14
THR A  67
ALA A  30
ALA A  31
 None
 1.17A 3ns1C-5tf2A:
undetectable		 3ns1C-5tf2A:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqc DIHYDROPYRIMIDINASE-
RELATED PROTEIN 2

(Mus musculus) 		PF01979
(Amidohydro_1) 		4 GLU A 232
THR A 313
ALA A 260
ALA A 261
 None
 1.25A 3ns1C-5uqcA:
undetectable		 3ns1C-5uqcA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w62 APOPTOSIS REGULATOR
BAX

(Mus musculus) 		no annotation 4 PHE A  93
THR A 140
ALA A  97
ALA A  96
 None
 1.24A 3ns1C-5w62A:
1.4		 3ns1C-5w62A:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5weg UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Saccharum
hybrid cultivar) 		no annotation 4 GLU A 323
PHE A 349
ALA A 345
ALA A 346
 None
 1.13A 3ns1C-5wegA:
undetectable		 3ns1C-5wegA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x32 N-ACYLGLUCOSAMINE
2-EPIMERASE

(Marinomonas
mediterranea) 		no annotation 4 GLU A 181
PHE A 117
ALA A 182
ALA A 116
 None
 1.00A 3ns1C-5x32A:
undetectable		 3ns1C-5x32A:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 4 PHE D 851
THR D 885
ALA D 845
ALA D 844
 None
 1.05A 3ns1C-5xbkD:
undetectable		 3ns1C-5xbkD:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xks THERMOSTABLE
MONOACYLGLYCEROL
LIPASE

(Geobacillus sp.
12AMOR1) 		no annotation 4 GLU A  66
PHE A 141
ALA A 165
ALA A 164
 None
 1.12A 3ns1C-5xksA:
undetectable		 3ns1C-5xksA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6acd -

(-) 		no annotation 4 PHE A 870
THR A 865
ALA A 874
ALA A 875
 None
 1.25A 3ns1C-6acdA:
undetectable		 3ns1C-6acdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f0k FE-S-CLUSTER-CONTAIN
ING HYDROGENASE

(Rhodothermus
marinus) 		no annotation 4 GLU B 329
ARG B 333
ALA B 330
ALA B 313
 None
 1.22A 3ns1C-6f0kB:
undetectable		 3ns1C-6f0kB:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fa5 PUTATIVE MRNA
SPLICING FACTOR

(Chaetomium
thermophilum) 		no annotation 4 GLU A 576
THR A 452
ALA A 618
ALA A 617
 None
 1.23A 3ns1C-6fa5A:
undetectable		 3ns1C-6fa5A:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fuz KINESIN LIGHT CHAIN
1,KINESIN LIGHT
CHAIN
1,C-JUN-AMINO-TERMIN
AL
KINASE-INTERACTING
PROTEIN 1

(Homo sapiens;
Mus musculus) 		no annotation 4 GLU A 434
ARG A 475
ALA A 482
ALA A 483
 None
 1.22A 3ns1C-6fuzA:
undetectable		 3ns1C-6fuzA:
8.63