SIMILAR PATTERNS OF AMINO ACIDS FOR 3NRR_A_D16A520
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1aol | GP70 (Murine leukemiavirus) |
PF00429(TLV_coat) | 5 | ALA A 174ASP A 108LEU A 105PRO A 68THR A 171 | None | 1.04A | 3nrrA-1aolA:undetectable | 3nrrA-1aolA:18.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1c8x | ENDO-BETA-N-ACETYLGLUCOSAMINIDASE H (Streptomycesplicatus) |
PF00704(Glyco_hydro_18) | 5 | ALA A 205ASP A 183LEU A 177ILE A 165LEU A 167 | ALA A 205 ( 0.0A)ASP A 183 ( 0.6A)LEU A 177 ( 0.6A)ILE A 165 ( 0.8A)LEU A 167 ( 0.5A) | 1.15A | 3nrrA-1c8xA:undetectable | 3nrrA-1c8xA:17.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cz3 | DIHYDROFOLATEREDUCTASE (Thermotogamaritima) |
PF00186(DHFR_1) | 6 | ALA A 8ASP A 27ARG A 32THR A 47ILE A 51THR A 121 | NoneNoneNoneSO4 A 200 (-3.7A)NoneNone | 0.60A | 3nrrA-1cz3A:17.5 | 3nrrA-1cz3A:16.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dcq | PYK2-ASSOCIATEDPROTEIN BETA (Mus musculus) |
PF01412(ArfGap)PF12796(Ank_2) | 5 | ALA A 473LEU A 465THR A 484ILE A 488LEU A 501 | None | 1.21A | 3nrrA-1dcqA:undetectable | 3nrrA-1dcqA:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dr6 | DIHYDROFOLATEREDUCTASE (Gallus gallus) |
PF00186(DHFR_1) | 5 | ALA A 9THR A 56ILE A 60PRO A 61THR A 136 | HBI A 198 ( 3.6A)NAP A 191 (-3.5A)NoneNoneHBI A 198 ( 4.5A) | 0.56A | 3nrrA-1dr6A:23.9 | 3nrrA-1dr6A:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g8x | MYOSIN II HEAVYCHAIN FUSED TOALPHA-ACTININ 3 (Dictyosteliumdiscoideum) |
PF00063(Myosin_head)PF00435(Spectrin)PF02736(Myosin_N) | 5 | PHE A 122ILE A 685SER A 92LEU A 676THR A 178 | None | 1.17A | 3nrrA-1g8xA:undetectable | 3nrrA-1g8xA:19.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1jio | CYTOCHROME P450107A1 (Saccharopolysporaerythraea) |
PF00067(p450) | 5 | ALA A 27ILE A 306PRO A 307SER A 310THR A 26 | None | 1.09A | 3nrrA-1jioA:undetectable | 3nrrA-1jioA:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nav | HORMONE RECEPTORALPHA 1, THRA1 (Homo sapiens) |
PF00104(Hormone_recep) | 5 | ASP A 312LEU A 311ILE A 360LEU A 367THR A 314 | None | 1.07A | 3nrrA-1navA:undetectable | 3nrrA-1navA:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1o94 | ELECTRON TRANSFERFLAVOPROTEINALPHA-SUBUNIT (Methylophilusmethylotrophus) |
PF01012(ETF) | 5 | PHE D 48LEU D 14ARG D 15PRO D 162LEU D 52 | None | 1.15A | 3nrrA-1o94D:2.8 | 3nrrA-1o94D:21.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p9m | INTERLEUKIN-6RECEPTOR BETA CHAIN (Homo sapiens) |
PF00041(fn3)PF06328(Lep_receptor_Ig)PF09240(IL6Ra-bind) | 5 | ALA A 73ASP A 71THR A 47ILE A 52PRO A 53 | None | 1.21A | 3nrrA-1p9mA:undetectable | 3nrrA-1p9mA:19.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rw9 | CHONDROITIN AC LYASE (Paenarthrobacteraurescens) |
PF02278(Lyase_8)PF02884(Lyase_8_C)PF08124(Lyase_8_N) | 5 | ALA A 261PHE A 9LEU A 12ARG A 13LEU A 256 | None | 1.22A | 3nrrA-1rw9A:undetectable | 3nrrA-1rw9A:21.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u70 | DIHYDROFOLATEREDUCTASE (Mus musculus) |
PF00186(DHFR_1) | 6 | ALA A 9PHE A 31THR A 56ILE A 60PRO A 61THR A 136 | NDP A 188 (-3.6A)MTX A 187 (-4.3A)NDP A 188 (-3.9A)MTX A 187 ( 4.2A)MTX A 187 (-4.8A)MTX A 187 (-4.4A) | 0.40A | 3nrrA-1u70A:23.3 | 3nrrA-1u70A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1u71 | DIHYDROFOLATEREDUCTASE (Homo sapiens) |
PF00186(DHFR_1) | 5 | ALA A 9THR A 56ILE A 60PRO A 61THR A 136 | MXA A 187 (-3.6A)SO4 A 188 (-3.5A)MXA A 187 ( 4.7A)MXA A 187 (-4.4A)MXA A 187 (-4.3A) | 0.31A | 3nrrA-1u71A:23.6 | 3nrrA-1u71A:23.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1um8 | ATP-DEPENDENT CLPPROTEASE ATP-BINDINGSUBUNIT CLPX (Helicobacterpylori) |
PF07724(AAA_2)PF10431(ClpB_D2-small) | 5 | ALA A 358LEU A 352ILE A 343SER A 344LEU A 398 | None | 1.18A | 3nrrA-1um8A:undetectable | 3nrrA-1um8A:23.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zdr | DIHYDROFOLATEREDUCTASE (Geobacillusstearothermophilus) |
PF00186(DHFR_1) | 5 | ALA A 7ASP A 27THR A 46ILE A 50THR A 115 | NoneNoneSO4 A3483 (-3.5A)SO4 A3486 ( 4.8A)None | 0.38A | 3nrrA-1zdrA:20.6 | 3nrrA-1zdrA:17.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0o | UPLC1 (Homo sapiens) |
PF01412(ArfGap)PF12796(Ank_2) | 5 | ALA E 646LEU E 638THR E 657ILE E 661LEU E 674 | None | 1.18A | 3nrrA-2b0oE:undetectable | 3nrrA-2b0oE:20.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2blb | DIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumvivax) |
PF00186(DHFR_1) | 5 | ALA A 15ASP A 53ILE A 121PRO A 122THR A 194 | CP7 A1240 (-3.7A)CP7 A1240 (-3.1A)MES A1241 ( 4.1A)NoneCP7 A1240 (-4.1A) | 0.44A | 3nrrA-2blbA:23.3 | 3nrrA-2blbA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ddz | 190AA LONGHYPOTHETICAL PROTEIN (Pyrococcushorikoshii) |
PF04017(DUF366) | 5 | ALA A 26PHE A 76ILE A 132PRO A 79LEU A 73 | NoneNoneNoneGAI A 510 ( 4.8A)None | 1.15A | 3nrrA-2ddzA:undetectable | 3nrrA-2ddzA:16.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 28ASP A 48ARG A 53THR A 80THR A 178 | NAP A 523 (-3.7A)NoneNoneNAP A 523 (-3.5A)None | 0.66A | 3nrrA-2h2qA:17.2 | 3nrrA-2h2qA:39.70 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2h2q | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomacruzi) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | ALA A 28ASP A 48THR A 80ILE A 84PRO A 85THR A 178 | NAP A 523 (-3.7A)NoneNAP A 523 (-3.5A)NoneNoneNone | 0.53A | 3nrrA-2h2qA:17.2 | 3nrrA-2h2qA:39.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2jkd | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 5 | PHE A 201LEU A 180ILE A 172PRO A 173LEU A 186 | None | 1.16A | 3nrrA-2jkdA:undetectable | 3nrrA-2jkdA:17.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kxr | TIGHT JUNCTIONPROTEIN ZO-1 (Homo sapiens) |
PF00791(ZU5) | 5 | ALA A 70LEU A 75ILE A 28PRO A 29THR A 62 | None | 1.00A | 3nrrA-2kxrA:undetectable | 3nrrA-2kxrA:11.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nra | PI PROTEIN (Escherichiacoli) |
PF01051(Rep_3) | 5 | ALA C 26LEU C 202ILE C 193SER C 194LEU C 174 | None | 1.19A | 3nrrA-2nraC:undetectable | 3nrrA-2nraC:22.16 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2oip | CHAIN A, CRYSTALSTRUCTURE OF DHFR (Cryptosporidiumhominis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ALA A 11ASP A 32THR A 58ILE A 62THR A 134 | MTX A 605 ( 3.6A)MTX A 605 ( 3.0A)NDP A 606 ( 3.5A)MTX A 605 ( 4.6A)MTX A 605 ( 4.2A) | 0.31A | 3nrrA-2oipA:44.4 | 3nrrA-2oipA:46.01 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pb0 | ACETYLORNITHINE/SUCCINYLDIAMINOPIMELATEAMINOTRANSFERASE (Salmonellaenterica) |
PF00202(Aminotran_3) | 5 | ALA A 178ASP A 175PHE A 208LEU A 176LEU A 215 | None | 1.22A | 3nrrA-2pb0A:undetectable | 3nrrA-2pb0A:20.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pdz | SYNTROPHIN (Mus musculus) |
PF00595(PDZ) | 5 | LEU A 80ILE A 28PRO A 27LEU A 71THR A 42 | None | 1.10A | 3nrrA-2pdzA:undetectable | 3nrrA-2pdzA:11.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2rkv | TRICHOTHECENE3-O-ACETYLTRANSFERASE (Fusariumgraminearum) |
PF02458(Transferase) | 5 | ALA A 57PHE A 49LEU A 46ILE A 168LEU A 139 | None | 1.13A | 3nrrA-2rkvA:undetectable | 3nrrA-2rkvA:23.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w3w | DIHYDROFOLATEREDUCTASE (Mycobacteriumavium) |
PF00186(DHFR_1) | 5 | ALA A 11ASP A 31THR A 50PRO A 55THR A 121 | VG9 A1168 ( 3.8A)VG9 A1168 (-3.0A)NDP A1169 (-3.4A)VG9 A1168 ( 4.6A)VG9 A1168 ( 4.7A) | 0.48A | 3nrrA-2w3wA:21.2 | 3nrrA-2w3wA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9s | DIHYDROFOLATEREDUCTASE TYPE 1FROM TN4003 (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA A 7ASP A 27THR A 46ILE A 50THR A 111 | TOP A1160 ( 3.6A)TOP A1160 (-2.8A)NDP A1159 (-3.3A)TOP A1160 (-4.4A)TOP A1160 ( 4.5A) | 0.45A | 3nrrA-2w9sA:20.7 | 3nrrA-2w9sA:17.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2wym | L-ASCORBATE-6-PHOSPHATE LACTONASE ULAG (Escherichiacoli) |
PF13483(Lactamase_B_3) | 5 | ALA A 115ASP A 61ILE A 107PRO A 104THR A 116 | NoneNoneGOL A1343 (-3.9A)NoneNone | 1.11A | 3nrrA-2wymA:undetectable | 3nrrA-2wymA:21.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xyb | LACCASE (Trametescinnabarina) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ASP A 458LEU A 457PRO A 367SER A 370THR A 114 | NoneGOL A 610 (-4.7A)NoneNoneNone | 1.11A | 3nrrA-2xybA:undetectable | 3nrrA-2xybA:22.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yx0 | RADICAL SAM ENZYME (Pyrococcushorikoshii) |
PF04055(Radical_SAM)PF08608(Wyosine_form) | 5 | ALA A 264LEU A 235THR A 177ILE A 175LEU A 185 | None | 1.07A | 3nrrA-2yx0A:undetectable | 3nrrA-2yx0A:19.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aib | GLUCOSYLTRANSFERASE-SI (Streptococcusmutans) |
PF02324(Glyco_hydro_70) | 5 | ALA A 645LEU A 547ARG A 554SER A 705LEU A 560 | None | 1.13A | 3nrrA-3aibA:undetectable | 3nrrA-3aibA:20.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cx6 | GUANINENUCLEOTIDE-BINDINGPROTEIN ALPHA-13SUBUNIT (Mus musculus) |
PF00503(G-alpha) | 5 | ALA A 349PHE A 289LEU A 246ILE A 51SER A 242 | GDP A 775 (-3.2A)NoneNoneNoneNone | 1.13A | 3nrrA-3cx6A:undetectable | 3nrrA-3cx6A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dfr | DIHYDROFOLATEREDUCTASE (Lactobacilluscasei) |
PF00186(DHFR_1) | 5 | ALA A 6ASP A 26THR A 45PRO A 50THR A 116 | MTX A 164 (-3.8A)MTX A 164 ( 2.9A)NDP A 163 (-3.4A)MTX A 164 ( 4.6A)MTX A 164 ( 4.3A) | 0.43A | 3nrrA-3dfrA:21.7 | 3nrrA-3dfrA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dg8 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1) | 6 | ALA A 16ASP A 54ILE A 112PRO A 113LEU A 164THR A 185 | RJ6 A 609 (-3.7A)RJ6 A 609 (-3.0A)RJ6 A 609 (-4.8A)NoneRJ6 A 609 ( 4.1A)RJ6 A 609 ( 4.5A) | 0.39A | 3nrrA-3dg8A:23.8 | 3nrrA-3dg8A:22.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dh9 | THIOREDOXINREDUCTASE 1 (Drosophilamelanogaster) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | PHE A 471LEU A 415ILE A 476LEU A 474THR A 467 | None | 1.22A | 3nrrA-3dh9A:undetectable | 3nrrA-3dh9A:22.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3els | PRE-MRNA LEAKAGEPROTEIN 1 (Saccharomycescerevisiae) |
PF00498(FHA) | 5 | PHE A 201LEU A 180ILE A 172PRO A 173LEU A 186 | NoneNoneNone CL A 205 ( 4.8A)None | 1.19A | 3nrrA-3elsA:undetectable | 3nrrA-3elsA:16.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3emv | URIDINEPHOSPHORYLASE,PUTATIVE (Plasmodiumvivax) |
PF01048(PNP_UDP_1) | 5 | ALA A 112PHE A 204THR A 200ILE A 88SER A 234 | None | 0.95A | 3nrrA-3emvA:undetectable | 3nrrA-3emvA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3fym | PUTATIVEUNCHARACTERIZEDPROTEIN (Staphylococcusaureus) |
PF13413(HTH_25) | 5 | LEU A1008ILE A1076PRO A1077SER A1050LEU A1068 | None | 1.12A | 3nrrA-3fymA:undetectable | 3nrrA-3fymA:12.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3g25 | GLYCEROL KINASE (Staphylococcusaureus) |
PF00370(FGGY_N)PF02782(FGGY_C) | 5 | ALA A 136ILE A 96PRO A 95LEU A 144THR A 188 | None | 1.16A | 3nrrA-3g25A:undetectable | 3nrrA-3g25A:20.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq9 | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 5 | ALA A 234LEU A 219ILE A 267SER A 264LEU A 192 | None | 1.20A | 3nrrA-3gq9A:undetectable | 3nrrA-3gq9A:20.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i8a | DIHYDROFOLATEREDUCTASE (Staphylococcusaureus) |
PF00186(DHFR_1) | 5 | ALA X 7ASP X 27THR X 46ILE X 50THR X 111 | N22 X 219 ( 3.6A)N22 X 219 (-2.8A)NDP X 207 (-3.2A)N22 X 219 (-4.6A)N22 X 219 (-4.4A) | 0.34A | 3nrrA-3i8aX:20.6 | 3nrrA-3i8aX:16.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k2v | PUTATIVE D-ARABINOSE5-PHOSPHATEISOMERASE (Klebsiellapneumoniae) |
PF00571(CBS) | 5 | THR A 218ILE A 222PRO A 223LEU A 320THR A 294 | None | 0.96A | 3nrrA-3k2vA:undetectable | 3nrrA-3k2vA:16.86 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 9 | PHE A 14ALA A 16ASP A 37LEU A 41THR A 69ILE A 73SER A 77LEU A 123THR A 144 | NoneNAP A 512 (-3.7A)NoneNoneNAP A 512 (-3.6A)NoneNoneNoneNone | 0.60A | 3nrrA-3kjrA:52.1 | 3nrrA-3kjrA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3kjr | DIHYDROFOLATEREDUCTASE/THYMIDYLATE SYNTHASE (Babesia bovis) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 9 | PHE A 14ALA A 16LEU A 41THR A 69ILE A 73PRO A 74SER A 77LEU A 123THR A 144 | NoneNAP A 512 (-3.7A)NoneNAP A 512 (-3.6A)NoneNoneNoneNoneNone | 0.71A | 3nrrA-3kjrA:52.1 | 3nrrA-3kjrA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3llq | AQUAPORIN Z 2 (Agrobacteriumfabrum) |
PF00230(MIP) | 5 | PHE A 43PHE A 62LEU A 15SER A 67LEU A 168 | None | 1.13A | 3nrrA-3llqA:undetectable | 3nrrA-3llqA:19.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lml | LIN1278 PROTEIN (Listeriainnocua) |
PF04984(Phage_sheath_1)PF17481(Phage_sheath_1N)PF17482(Phage_sheath_1C) | 5 | ALA A 43PHE A 74ARG A 78ILE A 55LEU A 40 | None | 1.15A | 3nrrA-3lmlA:undetectable | 3nrrA-3lmlA:23.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q9t | CHOLINEDEHYDROGENASE ANDRELATEDFLAVOPROTEINS (Aspergillusoryzae) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ASP A 545ILE A 552PRO A 553LEU A 305THR A 272 | FAY A 600 (-4.5A)NoneNoneNoneNone | 0.98A | 3nrrA-3q9tA:undetectable | 3nrrA-3q9tA:22.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rg9 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Trypanosomabrucei) |
PF00186(DHFR_1) | 6 | ALA A 34ASP A 54ARG A 59THR A 86PRO A 91THR A 184 | WRA A 602 (-3.9A)WRA A 602 (-2.9A)NoneNDP A 601 ( 3.2A)WRA A 602 (-4.3A)WRA A 602 (-4.2A) | 0.55A | 3nrrA-3rg9A:21.8 | 3nrrA-3rg9A:19.60 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3sm3 | SAM-DEPENDENTMETHYLTRANSFERASES (Methanosarcinamazei) |
PF08241(Methyltransf_11) | 5 | PHE A 220LEU A 190ILE A 124SER A 121LEU A 139 | None | 1.18A | 3nrrA-3sm3A:undetectable | 3nrrA-3sm3A:20.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t6w | LACCASE (Steccherinumochraceum) |
PF00394(Cu-oxidase)PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | ASP A 460LEU A 459PRO A 371SER A 374THR A 115 | NoneGOL A 508 (-4.6A)NoneNoneNone | 1.08A | 3nrrA-3t6wA:undetectable | 3nrrA-3t6wA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tq9 | DIHYDROFOLATEREDUCTASE (Coxiellaburnetii) |
PF00186(DHFR_1) | 5 | ALA A 8ASP A 28THR A 47ILE A 51THR A 115 | MTX A2001 ( 3.4A)MTX A2001 (-2.7A)NDP A1001 (-3.1A)MTX A2001 (-4.3A)MTX A2001 (-4.3A) | 0.38A | 3nrrA-3tq9A:21.2 | 3nrrA-3tq9A:17.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tqi | GMP SYNTHASE[GLUTAMINE-HYDROLYZING] (Coxiellaburnetii) |
PF00117(GATase)PF00958(GMP_synt_C)PF02540(NAD_synthase) | 5 | PHE A 176ALA A 167LEU A 121LEU A 83THR A 157 | None | 1.08A | 3nrrA-3tqiA:undetectable | 3nrrA-3tqiA:22.59 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3um6 | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Plasmodiumfalciparum) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 5 | ASP A 54THR A 108ILE A 112PRO A 113THR A 185 | 1CY A 609 (-2.9A)NDP A 610 ( 3.4A)1CY A 609 (-4.4A)None1CY A 609 (-4.3A) | 0.63A | 3nrrA-3um6A:42.2 | 3nrrA-3um6A:44.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vco | DIHYDROFOLATEREDUCTASE (Schistosomamansoni) |
PF00186(DHFR_1) | 6 | ALA A 8ASP A 28THR A 53ILE A 57PRO A 58THR A 133 | NoneNoneSO4 A 201 (-3.7A)NoneNoneNone | 0.71A | 3nrrA-3vcoA:20.1 | 3nrrA-3vcoA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3u | NADH:FLAVINOXIDOREDUCTASE/NADHOXIDASE (Zymomonasmobilis) |
PF00724(Oxidored_FMN) | 5 | ALA A 300ARG A 316PRO A 23LEU A 324THR A 299 | NoneFMN A1357 (-3.8A)FMN A1357 (-4.2A)NoneNone | 1.01A | 3nrrA-4a3uA:undetectable | 3nrrA-4a3uA:21.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 5 | PHE A 40ALA A 293LEU A 290ILE A 322SER A 326 | None | 1.17A | 3nrrA-4btgA:undetectable | 3nrrA-4btgA:21.48 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4d3y | LEGUMAIN (Cricetulusgriseus) |
PF01650(Peptidase_C13) | 5 | ALA A 223ILE A 79SER A 82LEU A 234THR A 310 | None | 1.08A | 3nrrA-4d3yA:undetectable | 3nrrA-4d3yA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4db1 | MYOSIN-7 (Homo sapiens) |
PF00063(Myosin_head)PF02736(Myosin_N) | 5 | ALA A 11ARG A 190ILE A 114PRO A 127LEU A 16 | NoneNoneNoneANP A 801 (-4.2A)None | 1.22A | 3nrrA-4db1A:undetectable | 3nrrA-4db1A:22.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4e3c | INHIBITOR OF NUCLEARFACTOR KAPPA-BKINASE SUBUNIT BETA (Homo sapiens) |
PF00069(Pkinase) | 5 | ALA A 567LEU A 594PRO A 262SER A 409LEU A 440 | None | 1.03A | 3nrrA-4e3cA:undetectable | 3nrrA-4e3cA:21.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4f92 | U5 SMALL NUCLEARRIBONUCLEOPROTEIN200 KDA HELICASE (Homo sapiens) |
PF00270(DEAD)PF00271(Helicase_C)PF02889(Sec63) | 5 | ALA B1088LEU B1114ILE B1046PRO B1045LEU B1014 | None | 0.99A | 3nrrA-4f92B:undetectable | 3nrrA-4f92B:15.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4g8z | DIHYDROFOLATEREDUCTASE (Pneumocystisjirovecii) |
PF00186(DHFR_1) | 5 | ALA X 12THR X 61ILE X 65PRO X 66THR X 144 | NDP X 302 ( 3.8A)NDP X 302 (-3.4A)TOP X 301 ( 4.3A)TOP X 301 (-4.8A)TOP X 301 (-4.5A) | 0.40A | 3nrrA-4g8zX:23.0 | 3nrrA-4g8zX:18.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h16 | SHORT CHAIN ALCOHOLDEHYDROGENASE-RELATED DEHYDROGENASE (Sinorhizobiummeliloti) |
PF13561(adh_short_C2) | 5 | PHE A 52LEU A 51ARG A 73ILE A 14LEU A 30 | None | 1.02A | 3nrrA-4h16A:undetectable | 3nrrA-4h16A:19.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h6q | PROLINEDEHYDROGENASE (Deinococcusradiodurans) |
PF01619(Pro_dh) | 5 | PHE A 149ASP A 181LEU A 179ARG A 176LEU A 146 | None | 0.81A | 3nrrA-4h6qA:undetectable | 3nrrA-4h6qA:19.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h96 | DIHYDROFOLATEREDUCTASE (Candidaalbicans) |
PF00186(DHFR_1) | 5 | ALA A 11THR A 58ILE A 62PRO A 63THR A 133 | 14Q A 202 ( 3.7A)NDP A 201 (-3.7A)14Q A 202 ( 4.8A)None14Q A 202 ( 4.6A) | 0.75A | 3nrrA-4h96A:20.0 | 3nrrA-4h96A:18.41 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h98 | DIHYDROFOLATEREDUCTASE ([Candida]glabrata) |
PF00186(DHFR_1) | 6 | ALA A 11ARG A 37THR A 58ILE A 62PRO A 63THR A 140 | 14Q A 302 ( 3.4A)NoneNDP A 301 (-3.5A)14Q A 302 (-4.2A)14Q A 302 (-4.4A)14Q A 302 (-4.2A) | 0.50A | 3nrrA-4h98A:20.3 | 3nrrA-4h98A:18.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hts | SEC-INDEPENDENTPROTEIN TRANSLOCASEPROTEIN TATC (Aquifexaeolicus) |
PF00902(TatC) | 5 | ALA A 203LEU A 130ILE A 43PRO A 42SER A 46 | None | 1.17A | 3nrrA-4htsA:undetectable | 3nrrA-4htsA:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i1s | MELANOMADIFFERENTIATIONASSOCIATED PROTEIN-5 (Sus scrofa) |
PF00271(Helicase_C) | 5 | LEU A 610THR A 558PRO A 568SER A 570LEU A 554 | None | 1.21A | 3nrrA-4i1sA:undetectable | 3nrrA-4i1sA:17.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kit | PRE-MRNA-PROCESSING-SPLICING FACTOR 8 (Homo sapiens) |
PF01398(JAB)PF08084(PROCT) | 5 | ALA C2227LEU C2188PRO C2232SER C2233THR C2226 | None | 1.16A | 3nrrA-4kitC:undetectable | 3nrrA-4kitC:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l9a | PUTATIVEUNCHARACTERIZEDPROTEIN SMU.1393C (Streptococcusmutans) |
no annotation | 5 | LEU A 275ILE A 53PRO A 50SER A 52LEU A 119 | None | 0.88A | 3nrrA-4l9aA:undetectable | 3nrrA-4l9aA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4m2x | DIHYDROFOLATEREDUCTASE (Mycobacteriumtuberculosis) |
PF00186(DHFR_1) | 5 | ALA A 7ASP A 27THR A 46PRO A 51THR A 113 | TMQ A 202 ( 3.5A)TMQ A 202 ( 2.7A)NDP A 201 (-3.4A)TMQ A 202 (-4.2A)TMQ A 202 (-4.2A) | 0.52A | 3nrrA-4m2xA:20.3 | 3nrrA-4m2xA:15.47 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4py3 | BARTONELLA EFFECTORPROTEIN (BEP)SUBSTRATE OF VIRBT4SS (Bartonella sp.1-1C) |
PF02661(Fic) | 5 | ASP A 121PHE A 120LEU A 117THR A 162SER A 151 | None | 1.12A | 3nrrA-4py3A:undetectable | 3nrrA-4py3A:21.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4twi | NAD-DEPENDENTPROTEIN DEACYLASE 1 (Archaeoglobusfulgidus) |
PF02146(SIR2) | 5 | ALA A 221LEU A 225THR A 8ILE A 9THR A 218 | None | 1.11A | 3nrrA-4twiA:undetectable | 3nrrA-4twiA:16.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ut1 | FLAGELLARHOOK-ASSOCIATEDPROTEIN (Burkholderiapseudomallei) |
PF06429(Flg_bbr_C) | 5 | LEU A 287THR A 244PRO A 248SER A 249LEU A 163 | NoneNoneEDO A1641 (-4.2A)NoneNone | 1.19A | 3nrrA-4ut1A:undetectable | 3nrrA-4ut1A:18.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4uvk | ZYRO0D15994P (Zygosaccharomycesrouxii) |
PF08514(STAG) | 5 | PHE A 726ASP A 730LEU A 729ARG A 687ILE A 693 | None | 1.19A | 3nrrA-4uvkA:undetectable | 3nrrA-4uvkA:19.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x0o | 3-OXOACYL-[ACYL-CARRIER-PROTEIN]SYNTHASE 3 PROTEIN 2 (Vibrio cholerae) |
PF08541(ACP_syn_III_C)PF08545(ACP_syn_III) | 5 | ALA A 67ILE A 101PRO A 102SER A 103THR A 9 | None | 1.05A | 3nrrA-4x0oA:undetectable | 3nrrA-4x0oA:21.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5cyu | CONSERVED MEMBRANEPROTEIN (Mycolicibacteriumsmegmatis) |
PF05108(T7SS_ESX1_EccB) | 5 | LEU A 371ARG A 368ILE A 364PRO A 182LEU A 170 | None | 1.21A | 3nrrA-5cyuA:undetectable | 3nrrA-5cyuA:20.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5g4x | SH3 AND MULTIPLEANKYRIN REPEATDOMAINS PROTEIN 3 (Rattusnorvegicus) |
PF12796(Ank_2)PF16511(FERM_f0) | 5 | ALA A 274LEU A 266THR A 285ILE A 289LEU A 302 | None | 1.22A | 3nrrA-5g4xA:undetectable | 3nrrA-5g4xA:21.90 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gr8 | LEUCINE-RICH REPEATRECEPTOR-LIKEPROTEIN KINASE PEPR1 (Arabidopsisthaliana) |
PF00560(LRR_1)PF08263(LRRNT_2)PF13855(LRR_8) | 5 | PHE A 168LEU A 197ILE A 215PRO A 212SER A 214 | None | 1.01A | 3nrrA-5gr8A:undetectable | 3nrrA-5gr8A:20.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5koh | NITROGENASE FEMOBETA SUBUNIT PROTEINNIFK (Gluconacetobacterdiazotrophicus) |
PF00148(Oxidored_nitro)PF11844(DUF3364) | 5 | PHE B 207ALA B 276THR B 286ILE B 222PRO B 223 | None | 1.09A | 3nrrA-5kohB:undetectable | 3nrrA-5kohB:23.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m1t | MUCRPHOSPHODIESTERASE (Pseudomonasaeruginosa) |
PF00563(EAL) | 5 | LEU A 539ILE A 587PRO A 606SER A 581LEU A 529 | None | 1.17A | 3nrrA-5m1tA:undetectable | 3nrrA-5m1tA:17.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5m8h | ATPPHOSPHORIBOSYLTRANSFERASE REGULATORYSUBUNIT (Psychrobacterarcticus) |
PF13393(tRNA-synt_His) | 5 | PHE A 204LEU A 165ARG A 164ILE A 235LEU A 207 | None | 1.07A | 3nrrA-5m8hA:undetectable | 3nrrA-5m8hA:20.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5mjr | PROTEIN THF1 (Thermosynechococcuselongatus) |
PF11264(ThylakoidFormat) | 5 | PHE A 142LEU A 139PRO A 121LEU A 167THR A 157 | None | 0.99A | 3nrrA-5mjrA:undetectable | 3nrrA-5mjrA:19.19 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ncc | FATTY ACIDPHOTODECARBOXYLASE (Chlorellavariabilis) |
PF00732(GMC_oxred_N)PF05199(GMC_oxred_C) | 5 | ASP A 609ILE A 616PRO A 617LEU A 379THR A 346 | FAD A 701 (-4.1A)NoneNoneNoneNone | 1.09A | 3nrrA-5nccA:undetectable | 3nrrA-5nccA:20.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5t0l | BIFUNCTIONALDIHYDROFOLATEREDUCTASE-THYMIDYLATE SYNTHASE (Toxoplasmagondii) |
PF00186(DHFR_1)PF00303(Thymidylat_synt) | 6 | ALA A 10ASP A 31PHE A 32THR A 83PRO A 88THR A 172 | 73X A 704 (-4.0A)73X A 704 (-2.8A)73X A 704 (-4.7A)NDP A 702 (-3.2A)73X A 704 (-4.0A)73X A 704 (-4.2A) | 0.40A | 3nrrA-5t0lA:46.0 | 3nrrA-5t0lA:42.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tdx | ANCESTRALHYDROXYNITRILE LYASE1 (syntheticconstruct) |
no annotation | 5 | ALA A 87PHE A 54ILE A 12SER A 177LEU A 106 | None | 1.21A | 3nrrA-5tdxA:undetectable | 3nrrA-5tdxA:22.59 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uqd | DUMPY: SHORTER THANWILD-TYPE (Caenorhabditiselegans) |
no annotation | 5 | LEU A1227ARG A1276THR A1249ILE A1251LEU A1287 | NonePG0 A1704 (-3.8A)NoneNoneNone | 1.16A | 3nrrA-5uqdA:undetectable | 3nrrA-5uqdA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vae | ACCESSORY SEC SYSTEMPROTEIN ASP1 (Streptococcusgordonii) |
no annotation | 5 | PHE A 4ALA A 234ASP A 34ARG A 40LEU A 51 | None | 1.11A | 3nrrA-5vaeA:undetectable | 3nrrA-5vaeA:8.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vbc | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEATXR5 (Ricinuscommunis) |
PF00856(SET) | 5 | ALA A 202LEU A 290ARG A 334SER A 336LEU A 195 | None | 0.98A | 3nrrA-5vbcA:undetectable | 3nrrA-5vbcA:18.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wwp | ORF1AB (Middle Eastrespiratorysyndrome-relatedcoronavirus) |
no annotation | 5 | PHE B 133ALA B 135LEU B 109ARG B 108LEU B 130 | None | 1.07A | 3nrrA-5wwpB:undetectable | 3nrrA-5wwpB:21.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x1y | MERCURIC REDUCTASE (Lysinibacillussphaericus) |
no annotation | 5 | LEU B 133ILE B 248PRO B 249SER B 273LEU B 163 | None | 1.02A | 3nrrA-5x1yB:undetectable | 3nrrA-5x1yB:21.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x8g | 2-SUCCINYLBENZOATE--COA LIGASE (Bacillussubtilis) |
PF00501(AMP-binding)PF13193(AMP-binding_C) | 5 | ALA A 191ARG A 187ILE A 257PRO A 254SER A 256 | None | 1.16A | 3nrrA-5x8gA:undetectable | 3nrrA-5x8gA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6b6m | CYANATE HYDRATASE (Serratiaproteamaculans) |
no annotation | 5 | ALA A 57THR A 2ILE A 78PRO A 79THR A 36 | None | 1.18A | 3nrrA-6b6mA:undetectable | 3nrrA-6b6mA:15.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6caa | ELECTROGENIC SODIUMBICARBONATECOTRANSPORTER 1 (Homo sapiens) |
no annotation | 5 | LEU A 861ILE A 688SER A 663LEU A 434THR A 442 | None | 1.19A | 3nrrA-6caaA:undetectable | 3nrrA-6caaA:8.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cxm | DIHYDROFOLATEREDUCTASE (Mycolicibacteriumsmegmatis) |
no annotation | 5 | ALA A 8ASP A 28THR A 47PRO A 52THR A 111 | NAP A 201 (-3.9A)MMV A 202 (-2.9A)NAP A 201 (-3.3A)MMV A 202 ( 4.6A)MMV A 202 (-4.4A) | 0.45A | 3nrrA-6cxmA:20.2 | 3nrrA-6cxmA:7.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6e4e | - (-) |
no annotation | 5 | ALA A 7ASP A 27THR A 46ILE A 50THR A 111 | MMV A 202 ( 3.5A)MMV A 202 (-2.9A)NAP A 201 ( 3.3A)MMV A 202 ( 4.9A)MMV A 202 (-4.3A) | 0.38A | 3nrrA-6e4eA:20.6 | 3nrrA-6e4eA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6esq | HYDROXYMETHYLGLUTARYL-COA SYNTHASE (Methanothermococcusthermolithotrophicus) |
no annotation | 5 | THR I 325ILE I 13PRO I 14SER I 44THR I 118 | None | 1.21A | 3nrrA-6esqI:undetectable | 3nrrA-6esqI:10.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6ffl | MALTOSE/MALTODEXTRINTRANSPORT PERMEASEHOMOLOGUE (Bdellovibriobacteriovorus) |
no annotation | 5 | ALA A 168LEU A 354THR A 190PRO A 368LEU A 188 | None | 1.22A | 3nrrA-6fflA:undetectable | 3nrrA-6fflA:10.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6req | PROTEIN(METHYLMALONYL-COAMUTASE) (Propionibacteriumfreudenreichii) |
PF01642(MM_CoA_mutase) | 5 | ALA B 124LEU B 136SER B 357LEU B 129THR B 121 | None | 1.21A | 3nrrA-6reqB:undetectable | 3nrrA-6reqB:20.94 |