SIMILAR PATTERNS OF AMINO ACIDS FOR 3NNE_G_ACTG601_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bqg D-GLUCARATE
DEHYDRATASE

(Pseudomonas
putida) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 118
ILE A  67
VAL A  21
ASN A  45
 None
 1.18A 3nneG-1bqgA:
undetectable		 3nneG-1bqgA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxk PROTEIN
(DTDP-GLUCOSE
4,6-DEHYDRATASE)

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 ALA A  16
ILE A  13
HIS A 232
ASN A 190
 None
NAD  A 380 (-3.6A)
None
NAD  A 380 (-4.5A)
 1.20A 3nneG-1bxkA:
1.9		 3nneG-1bxkA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgs DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ALA A 378
ILE A 382
VAL A 191
HIS A 357
 None
 1.04A 3nneG-1dgsA:
undetectable		 3nneG-1dgsA:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g1a DTDP-D-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 ALA A  15
ILE A  12
HIS A 239
ASN A 197
 None
NAD  A 400 (-3.8A)
None
NAD  A 400 (-4.8A)
 1.15A 3nneG-1g1aA:
0.0		 3nneG-1g1aA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hz4 MALT REGULATORY
PROTEIN

(Escherichia
coli) 		no annotation 4 ALA A 117
ILE A 121
HIS A 132
VAL A 136
 None
 1.13A 3nneG-1hz4A:
undetectable		 3nneG-1hz4A:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8i MHC CLASS II H2-M
ALPHA CHAIN
MHC CLASS II H2-M
BETA 2 CHAIN

(Mus musculus;
Mus musculus) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set)
PF00969
(MHC_II_beta)
PF07654
(C1-set) 		4 ALA A  68
ILE A  69
HIS A  17
HIS B  81
 None
 1.15A 3nneG-1k8iA:
undetectable		 3nneG-1k8iA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kon PROTEIN YEBC

(Escherichia
coli) 		PF01709
(Transcrip_reg) 		4 ALA A 213
ILE A 238
HIS A  12
HIS A 234
 None
 1.06A 3nneG-1konA:
undetectable		 3nneG-1konA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nba N-CARBAMOYLSARCOSINE
AMIDOHYDROLASE

(Arthrobacter
sp.) 		PF00857
(Isochorismatase) 		4 ILE A 133
HIS A  49
VAL A  89
ASN A  79
 None
 0.99A 3nneG-1nbaA:
undetectable		 3nneG-1nbaA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvm ACETALDEHYDE
DEHYDROGENASE
(ACYLATING)

(Pseudomonas sp.
CF600) 		PF01118
(Semialdhyde_dh)
PF09290
(AcetDehyd-dimer) 		4 ALA B 107
ILE B 108
HIS B  84
ASN B 126
 None
 1.01A 3nneG-1nvmB:
undetectable		 3nneG-1nvmB:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nye OSMOTICALLY
INDUCIBLE PROTEIN C

(Escherichia
coli) 		PF02566
(OsmC) 		4 ALA A 153
ILE A 155
HIS A  76
VAL A 147
 None
 1.14A 3nneG-1nyeA:
undetectable		 3nneG-1nyeA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		4 ALA A  86
ILE A  85
HIS A 106
VAL A 114
 None
 1.09A 3nneG-1s7gA:
undetectable		 3nneG-1s7gA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uar RHODANESE

(Thermus
thermophilus) 		PF00581
(Rhodanese) 		4 ALA A 200
ILE A 197
VAL A 237
HIS A 156
 None
 1.15A 3nneG-1uarA:
undetectable		 3nneG-1uarA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9p DNA LIGASE

(Thermus
filiformis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB)
PF12826
(HHH_2)
PF14520
(HHH_5) 		4 ALA A 381
ILE A 385
VAL A 196
HIS A 360
 None
 0.91A 3nneG-1v9pA:
undetectable		 3nneG-1v9pA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkn N-ACETYL-GAMMA-GLUTA
MYL-PHOSPHATE
REDUCTASE

(Thermotoga
maritima) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 ALA A   4
ILE A   2
HIS A  24
VAL A 317
 None
 1.16A 3nneG-1vknA:
1.8		 3nneG-1vknA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f1k PREPHENATE
DEHYDROGENASE

(Synechocystis
sp. PCC 6803) 		PF02153
(PDH) 		4 ALA A 236
HIS A 179
VAL A 174
HIS A 170
 None
None
OMT  A 114 ( 4.7A)
None
 1.21A 3nneG-2f1kA:
undetectable		 3nneG-2f1kA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivd PROTOPORPHYRINOGEN
OXIDASE

(Myxococcus
xanthus) 		PF01593
(Amino_oxidase) 		4 ALA A 344
ILE A 345
VAL A 313
HIS A 315
 None
 1.08A 3nneG-2ivdA:
13.4		 3nneG-2ivdA:
26.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ALA A 260
ILE A 261
VAL A 283
ASN A 255
 None
 1.10A 3nneG-2j6iA:
2.0		 3nneG-2j6iA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7a CYTOCHROME C NITRITE
REDUCTASE NRFA

(Desulfovibrio
vulgaris) 		PF02335
(Cytochrom_C552) 		4 ILE A 480
HIS A 497
VAL A 477
ASN A 104
 None
 1.15A 3nneG-2j7aA:
undetectable		 3nneG-2j7aA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nv5 PTPRD, PHOSPHATASE

(Rattus
norvegicus) 		PF00102
(Y_phosphatase) 		4 ALA A1262
ILE A1261
VAL A1428
ASN A1464
 None
 1.19A 3nneG-2nv5A:
undetectable		 3nneG-2nv5A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odl ADHESIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 ALA A  98
ILE A 100
VAL A 146
ASN A 126
 None
 0.81A 3nneG-2odlA:
undetectable		 3nneG-2odlA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph5 HOMOSPERMIDINE
SYNTHASE

(Legionella
pneumophila) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 ALA A 239
ILE A 241
HIS A 318
VAL A 276
 None
 1.14A 3nneG-2ph5A:
undetectable		 3nneG-2ph5A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		4 ALA A 218
ILE A  48
HIS A  44
VAL A 267
 None
 1.21A 3nneG-2r94A:
undetectable		 3nneG-2r94A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpw HYPOTHETICAL
MEMBRANE SPANNING
PROTEIN

(Thermus
thermophilus) 		PF14589
(NrfD_2) 		4 ALA C 134
ILE C  89
VAL C  25
HIS C  21
 None
MQ7  C1252 (-3.8A)
None
MQ7  C1252 (-4.1A)
 1.15A 3nneG-2vpwC:
undetectable		 3nneG-2vpwC:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		4 ALA A 136
ILE A 134
HIS A  99
VAL A  82
 None
 0.89A 3nneG-2xsgA:
undetectable		 3nneG-2xsgA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yrr AMINOTRANSFERASE,
CLASS V

(Thermus
thermophilus) 		PF00266
(Aminotran_5) 		4 ALA A  55
HIS A 223
HIS A 238
ASN A  35
 None
 1.00A 3nneG-2yrrA:
undetectable		 3nneG-2yrrA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zbw THIOREDOXIN
REDUCTASE

(Thermus
thermophilus) 		PF07992
(Pyr_redox_2) 		4 ALA A 306
ILE A 307
HIS A 311
VAL A 322
 None
 1.19A 3nneG-2zbwA:
11.9		 3nneG-2zbwA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9x SELENOCYSTEINE LYASE

(Rattus
norvegicus) 		PF00266
(Aminotran_5) 		4 ILE A 136
HIS A 219
VAL A  94
ASN A  91
 None
None
None
PLP  A 501 (-4.5A)
 1.03A 3nneG-3a9xA:
undetectable		 3nneG-3a9xA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b8k DIHYDROLIPOYLLYSINE-
RESIDUE
ACETYLTRANSFERASE

(Homo sapiens) 		PF00198
(2-oxoacid_dh) 		4 ALA A 503
ILE A 504
VAL A 427
ASN A 481
 None
 1.19A 3nneG-3b8kA:
undetectable		 3nneG-3b8kA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 ILE A  36
VAL A 185
HIS A 204
ASN A  32
 None
 1.09A 3nneG-3cv3A:
2.6		 3nneG-3cv3A:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		4 ALA A 163
ILE A 192
VAL A 188
ASN A 190
 None
 1.22A 3nneG-3dnfA:
undetectable		 3nneG-3dnfA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e13 PUTATIVE IRON-UPTAKE
ABC TRANSPORT
SYSTEM,PERIPLASMIC
IRON-BINDING PROTEIN

(Campylobacter
jejuni) 		PF13343
(SBP_bac_6) 		4 ALA X 305
ILE X  64
HIS X 235
ASN X 237
 None
 1.18A 3nneG-3e13X:
undetectable		 3nneG-3e13X:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eez PUTATIVE MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 203
ILE A 230
HIS A 234
VAL A 238
 None
 1.21A 3nneG-3eezA:
undetectable		 3nneG-3eezA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3err FUSION PROTEIN OF
MICROTUBULE BINDING
DOMAIN FROM MOUSE
CYTOPLASMIC DYNEIN
AND SERYL-TRNA
SYNTHETASE FROM
THERMUS THERMOPHILUS

(Thermus
thermophilus;
Mus musculus) 		PF00587
(tRNA-synt_2b)
PF12777
(MT) 		4 ALA A3314
ILE A3379
VAL A3391
ASN A3376
 None
 1.10A 3nneG-3errA:
undetectable		 3nneG-3errA:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fgq NEUROSERPIN

(Homo sapiens) 		PF00079
(Serpin) 		4 ALA A  56
ILE A  53
HIS A 338
VAL A 184
 None
 1.00A 3nneG-3fgqA:
undetectable		 3nneG-3fgqA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g79 NDP-N-ACETYL-D-GALAC
TOSAMINURONIC ACID
DEHYDROGENASE

(Methanosarcina
mazei) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		4 ALA A 253
ILE A 468
HIS A 335
HIS A 474
 None
 1.05A 3nneG-3g79A:
2.6		 3nneG-3g79A:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3glq ADENOSYLHOMOCYSTEINA
SE

(Burkholderia
pseudomallei) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		4 ILE A 378
HIS A 368
HIS A 335
ASN A 336
 None
 1.06A 3nneG-3glqA:
3.0		 3nneG-3glqA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzd SELENOCYSTEINE LYASE

(Homo sapiens) 		PF00266
(Aminotran_5) 		4 ILE C 148
HIS C 231
VAL C 106
ASN C 103
 None
None
None
PLR  C 500 ( 4.6A)
 1.03A 3nneG-3gzdC:
undetectable		 3nneG-3gzdC:
24.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzu THIOSULFATE
SULFURTRANSFERASE
SSEA

(Mycobacterium
tuberculosis) 		PF00581
(Rhodanese) 		4 ALA A  36
ILE A  87
HIS A 116
VAL A 119
 None
 1.19A 3nneG-3hzuA:
undetectable		 3nneG-3hzuA:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3ljp CHOLINE OXIDASE

(Arthrobacter
globiformis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		4 ILE A 103
HIS A 351
HIS A 466
ASN A 510
 FDA  A 547 (-3.5A)
None
FDA  A 547 ( 4.6A)
FDA  A 547 (-4.6A)
 0.21A 3nneG-3ljpA:
67.6		 3nneG-3ljpA:
99.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mux PUTATIVE
4-HYDROXY-2-OXOGLUTA
RATE ALDOLASE

(Bacillus
anthracis) 		PF07071
(KDGP_aldolase) 		4 ALA A  14
HIS A  92
HIS A 218
ASN A  16
 None
 1.12A 3nneG-3muxA:
undetectable		 3nneG-3muxA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3niz RHODANESE FAMILY
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 ALA A  66
ILE A  67
VAL A  87
HIS A  89
 None
 1.17A 3nneG-3nizA:
undetectable		 3nneG-3nizA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o98 BIFUNCTIONAL
GLUTATHIONYLSPERMIDI
NE
SYNTHETASE/AMIDASE

(Escherichia
coli) 		PF03738
(GSP_synth)
PF05257
(CHAP) 		4 ALA A 146
ILE A 145
VAL A 150
HIS A 131
 None
None
None
TS5  A 620 (-4.1A)
 1.05A 3nneG-3o98A:
undetectable		 3nneG-3o98A:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pfr MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Actinobacillus
succinogenes) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A 113
ILE A  62
VAL A  16
ASN A  40
 None
 1.10A 3nneG-3pfrA:
undetectable		 3nneG-3pfrA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpc POSSIBLE
METAL-DEPENDENT
HYDROLASE

(Veillonella
parvula) 		PF12706
(Lactamase_B_2) 		4 ALA A 191
ILE A 201
HIS A 129
HIS A  74
 None
None
ZN  A 301 (-3.3A)
ZN  A 302 (-3.4A)
 1.05A 3nneG-3rpcA:
undetectable		 3nneG-3rpcA:
19.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2s PUTATIVE
PYRAZINAMIDASE/NICOT
INAMIDASE

(Streptococcus
mutans) 		PF00857
(Isochorismatase) 		4 ALA A 141
ILE A 142
VAL A 176
HIS A 172
 None
 1.16A 3nneG-3s2sA:
undetectable		 3nneG-3s2sA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 ALA A 114
ILE A 110
HIS A 107
ASN A 123
 None
 1.15A 3nneG-3txxA:
2.1		 3nneG-3txxA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v7p AMIDOHYDROLASE
FAMILY PROTEIN

(Nitratiruptor
sp. SB155-2) 		PF01979
(Amidohydro_1) 		4 ALA A 177
ILE A 119
HIS A 206
VAL A 256
 None
None
FE  A 429 (-3.3A)
None
 1.18A 3nneG-3v7pA:
undetectable		 3nneG-3v7pA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w01 HEPTAPRENYLGLYCERYL
PHOSPHATE SYNTHASE

(Staphylococcus
aureus) 		PF01884
(PcrB) 		4 ALA A 200
ILE A 225
HIS A   9
VAL A 208
 None
 1.06A 3nneG-3w01A:
undetectable		 3nneG-3w01A:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zjk BETA GLYCOSIDASE

(Thermus
thermophilus) 		PF00232
(Glyco_hydro_1) 		4 ALA A 160
ILE A 216
HIS A 199
VAL A 203
 None
 1.19A 3nneG-3zjkA:
undetectable		 3nneG-3zjkA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a1o BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Mycobacterium
tuberculosis) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		4 ALA A 312
ILE A 281
HIS A 301
VAL A 331
 None
 0.97A 3nneG-4a1oA:
undetectable		 3nneG-4a1oA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2q RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ALA A 111
ILE A 541
HIS A 545
VAL A 575
 None
 0.95A 3nneG-4a2qA:
undetectable		 3nneG-4a2qA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2w RETINOIC ACID
INDUCIBLE PROTEIN I

(Anas
platyrhynchos) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF16739
(CARD_2) 		4 ALA A 111
ILE A 541
HIS A 545
VAL A 575
 None
 0.89A 3nneG-4a2wA:
undetectable		 3nneG-4a2wA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aco CENTROMERE
DNA-BINDING PROTEIN
COMPLEX CBF3 SUBUNIT
A

(Saccharomyces
cerevisiae) 		PF16787
(NDC10_II) 		4 ILE A  94
HIS A 158
VAL A 154
HIS A  86
 None
 1.20A 3nneG-4acoA:
undetectable		 3nneG-4acoA:
18.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aur LEOA

(Escherichia
coli) 		PF00350
(Dynamin_N) 		4 ALA A  14
ILE A  49
VAL A 268
HIS A 139
 None
 1.22A 3nneG-4aurA:
undetectable		 3nneG-4aurA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 ILE A 150
HIS A  68
VAL A  97
ASN A  94
 None
 1.01A 3nneG-4b8wA:
undetectable		 3nneG-4b8wA:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		4 ALA A 363
ILE A 382
HIS A 419
VAL A 433
 None
 1.20A 3nneG-4b9yA:
undetectable		 3nneG-4b9yA:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ALA A1427
ILE A1426
VAL A1593
ASN A1629
 None
 1.19A 3nneG-4bpcA:
undetectable		 3nneG-4bpcA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4brj DESULFOFERRODOXIN,
FERROUS IRON-BINDING
REGION

(Ignicoccus
hospitalis) 		PF01880
(Desulfoferrodox) 		4 ALA A  22
ILE A  19
HIS A  25
HIS A  56
 None
None
FE  A1125 (-3.3A)
FE  A1125 (-3.5A)
 0.84A 3nneG-4brjA:
undetectable		 3nneG-4brjA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 ALA A 329
ILE A 354
VAL A 358
HIS A  48
 None
 1.13A 3nneG-4fwgA:
undetectable		 3nneG-4fwgA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyp GLUCARATE
DEHYDRATASE-RELATED
PROTEIN

(Escherichia
coli) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA C 111
ILE C  60
VAL C  14
ASN C  38
 None
 1.11A 3nneG-4gypC:
undetectable		 3nneG-4gypC:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		4 ALA A  65
ILE A 127
VAL A  82
HIS A  84
 None
 1.18A 3nneG-4h0oA:
undetectable		 3nneG-4h0oA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jdz SER-ASP RICH
FIBRINOGEN/BONE
SIALOPROTEIN-BINDING
PROTEIN SDRD

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C)
PF17210
(SdrD_B) 		4 ALA A 253
ILE A 254
VAL A 260
ASN A 256
 None
CA  A 701 (-4.2A)
None
CA  A 701 (-2.9A)
 1.10A 3nneG-4jdzA:
undetectable		 3nneG-4jdzA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kp4 OSMOLARITY SENSOR
PROTEIN ENVZ,
HISTIDINE KINASE

(Escherichia
coli;
Thermotoga
maritima) 		PF00512
(HisKA)
PF02518
(HATPase_c) 		4 ALA A1407
ILE A1408
HIS A 243
ASN A1343
 None
None
ANP  A1501 (-4.1A)
None
 0.77A 3nneG-4kp4A:
undetectable		 3nneG-4kp4A:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		4 ALA A 298
ILE A 299
VAL A 358
ASN A 235
 None
 1.10A 3nneG-4mptA:
undetectable		 3nneG-4mptA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		4 ALA A 222
ILE A 212
HIS A 138
ASN A 136
 None
 1.16A 3nneG-4p05A:
undetectable		 3nneG-4p05A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p5p THIJ/PFPI FAMILY
PROTEIN

(Francisella
tularensis) 		PF01965
(DJ-1_PfpI) 		4 ALA A 136
ILE A 139
HIS A 115
ASN A 140
 None
 0.91A 3nneG-4p5pA:
1.7		 3nneG-4p5pA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		4 ALA A 232
ILE A 128
VAL A 227
HIS A 253
 None
PO4  A 301 (-4.1A)
None
None
 1.03A 3nneG-4rncA:
undetectable		 3nneG-4rncA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x3f SERINE/THREONINE-PRO
TEIN KINASE PKNA

(Mycobacterium
tuberculosis) 		PF00069
(Pkinase) 		4 ALA A 189
ILE A 184
HIS A 229
VAL A 225
 None
None
None
TPO  A 224 ( 3.3A)
 1.20A 3nneG-4x3fA:
undetectable		 3nneG-4x3fA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjv S-ACYL FATTY ACID
SYNTHASE
THIOESTERASE, MEDIUM
CHAIN

(Homo sapiens) 		PF00975
(Thioesterase) 		4 ALA A 107
ILE A 106
HIS A  56
VAL A  82
 None
 1.03A 3nneG-4xjvA:
undetectable		 3nneG-4xjvA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjf D-AMINO-ACID OXIDASE

(Sus scrofa) 		PF01266
(DAO) 		4 ILE B  11
HIS B 311
VAL B 289
ASN B 308
 FAD  B 401 (-4.0A)
None
None
None
 1.21A 3nneG-4yjfB:
10.7		 3nneG-4yjfB:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ALA A1273
ILE A1270
HIS A1171
ASN A1173
 None
 1.14A 3nneG-4yswA:
undetectable		 3nneG-4yswA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a3m CEA1

(Komagataella
pastoris) 		PF10528
(GLEYA) 		4 ALA A  49
ILE A  51
VAL A 104
ASN A  79
 None
 1.11A 3nneG-5a3mA:
undetectable		 3nneG-5a3mA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ail POLY [ADP-RIBOSE]
POLYMERASE 9

(Homo sapiens) 		PF01661
(Macro) 		4 ALA A 321
ILE A 317
HIS A 358
ASN A 301
 None
 1.15A 3nneG-5ailA:
undetectable		 3nneG-5ailA:
16.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b7z UNCHARACTERIZED
PROTEIN TM_0416

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 ALA A  66
ILE A 110
HIS A 208
VAL A   6
 None
None
NI  A 305 (-3.0A)
None
 0.84A 3nneG-5b7zA:
undetectable		 3nneG-5b7zA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c2v HYDRAZINE SYNTHASE
ALPHA SUBUNIT

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 4 ALA A 711
HIS A 512
VAL A 706
ASN A 717
 None
 1.18A 3nneG-5c2vA:
undetectable		 3nneG-5c2vA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fmg PROTEASOME SUBUNIT
BETA TYPE

(Plasmodium
falciparum) 		PF00227
(Proteasome) 		4 ALA L 135
ILE L 138
HIS L 162
ASN L 158
 None
 1.16A 3nneG-5fmgL:
undetectable		 3nneG-5fmgL:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 ALA A  47
ILE A  43
HIS A  88
ASN A  27
 None
 1.17A 3nneG-5fudA:
undetectable		 3nneG-5fudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fud O-ACETYL-ADP-RIBOSE
DEACETYLASE

(Oceanobacillus
iheyensis) 		PF01661
(Macro) 		4 ILE A  43
HIS A  44
HIS A  88
ASN A  27
 None
 1.09A 3nneG-5fudA:
undetectable		 3nneG-5fudA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hgc SERPIN

(Taeniopygia
guttata) 		PF00079
(Serpin) 		4 ALA A  65
ILE A  62
HIS A 339
VAL A 193
 None
 1.01A 3nneG-5hgcA:
undetectable		 3nneG-5hgcA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		4 ALA A  39
ILE A  59
HIS A  63
HIS A 131
 None
 1.08A 3nneG-5i32A:
undetectable		 3nneG-5i32A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		4 ALA A 248
ILE A 241
VAL A 162
ASN A 239
 None
 1.17A 3nneG-5i7nA:
undetectable		 3nneG-5i7nA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1d PHOSPHATE BINDING
PROTEIN

(Stenotrophomonas
maltophilia) 		PF12849
(PBP_like_2) 		4 ALA A 330
ILE A  23
HIS A 313
VAL A  95
 None
 1.17A 3nneG-5j1dA:
undetectable		 3nneG-5j1dA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3s SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		4 ALA A 167
ILE A 164
VAL A 134
ASN A 162
 None
 1.21A 3nneG-5l3sA:
2.8		 3nneG-5l3sA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN2

(Saccharomyces
cerevisiae) 		PF01851
(PC_rep)
PF13646
(HEAT_2) 		4 ALA N 446
ILE N 426
VAL N 439
ASN N 430
 None
 1.22A 3nneG-5mpdN:
undetectable		 3nneG-5mpdN:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnz DYNEIN ASSEMBLY
FACTOR WITH WDR
REPEAT DOMAINS 1

(Homo sapiens) 		no annotation 4 ALA B 201
ILE B 222
HIS B 218
VAL B 244
 None
 1.19A 3nneG-5nnzB:
undetectable		 3nneG-5nnzB:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 ALA A3884
ILE A3881
HIS A4006
HIS A3877
 None
 1.12A 3nneG-5nugA:
undetectable		 3nneG-5nugA:
8.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o5i ROUNDABOUT HOMOLOG 1

(Homo sapiens) 		no annotation 4 ALA A 527
ILE A 486
VAL A 483
ASN A 507
 None
 1.18A 3nneG-5o5iA:
undetectable		 3nneG-5o5iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o82 INTRACELLULAR
EXO-ALPHA-(1->5)-L-A
RABINOFURANOSIDASE

(Chaetomium
thermophilum) 		no annotation 4 ILE A 107
HIS A 163
VAL A 159
ASN A 108
 None
 1.22A 3nneG-5o82A:
undetectable		 3nneG-5o82A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ocs PUTATIVE
NADH-DEPENTDENT
FLAVIN
OXIDOREDUCTASE

(Cupriavidus
metallidurans) 		PF00724
(Oxidored_FMN) 		4 ALA A  20
ILE A  54
HIS A 263
VAL A 300
 None
None
None
FMN  A 401 (-4.5A)
 0.86A 3nneG-5ocsA:
undetectable		 3nneG-5ocsA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5of4 TFIIH BASAL
TRANSCRIPTION FACTOR
COMPLEX HELICASE XPD
SUBUNIT

(Homo sapiens) 		PF06733
(DEAD_2)
PF06777
(HBB)
PF13307
(Helicase_C_2) 		4 ALA B 236
ILE B 239
VAL B 454
HIS B  37
 None
 0.84A 3nneG-5of4B:
undetectable		 3nneG-5of4B:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5svc ACETONE CARBOXYLASE
ALPHA SUBUNIT

(Xanthobacter
autotrophicus) 		PF02538
(Hydantoinase_B) 		4 ALA A 605
ILE A 606
HIS A 402
VAL A 294
 None
 1.07A 3nneG-5svcA:
1.8		 3nneG-5svcA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5swn FLUOROACETATE
DEHALOGENASE

(Rhodopseudomonas
palustris) 		PF00561
(Abhydrolase_1) 		4 ALA A 205
HIS A 201
VAL A  45
HIS A  44
 None
 1.16A 3nneG-5swnA:
undetectable		 3nneG-5swnA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tr0 SEED LINOLEATE
13S-LIPOXYGENASE-1

(Glycine max) 		no annotation 4 ALA A 686
ILE A 837
VAL A 511
ASN A 535
 None
 1.00A 3nneG-5tr0A:
undetectable		 3nneG-5tr0A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8s CELL DIVISION
CONTROL PROTEIN 45

(Saccharomyces
cerevisiae) 		PF02724
(CDC45) 		4 ALA E 427
ILE E 496
VAL E 489
ASN E 493
 None
 0.94A 3nneG-5u8sE:
undetectable		 3nneG-5u8sE:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vnx 8-AMINO-7-OXONONANOA
TE SYNTHASE

(Burkholderia
multivorans) 		PF00155
(Aminotran_1_2) 		4 ALA A 243
HIS A 211
VAL A 326
ASN A  47
 9EV  A 242 ( 3.7A)
9EV  A 242 ( 3.5A)
None
9EV  A 242 ( 4.0A)
 1.14A 3nneG-5vnxA:
undetectable		 3nneG-5vnxA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtd NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Homo sapiens) 		PF01370
(Epimerase) 		4 ALA J 153
ILE J 152
HIS J 166
ASN J 128
 None
 1.12A 3nneG-5xtdJ:
undetectable		 3nneG-5xtdJ:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao1 BETA-LACTAMASE
DOMAIN PROTEIN

(Paraburkholderia
phymatum) 		PF00753
(Lactamase_B) 		4 ALA A 305
HIS A 148
VAL A 236
HIS A 334
 None
 1.16A 3nneG-6ao1A:
undetectable		 3nneG-6ao1A:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6enx NAD-DEPENDENT
PROTEIN DEACYLASE
SIRTUIN-5,
MITOCHONDRIAL

(Danio rerio) 		no annotation 4 ALA A 118
ILE A 117
HIS A 142
VAL A 150
 None
 1.08A 3nneG-6enxA:
undetectable		 3nneG-6enxA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 4 ALA P 118
ILE P 117
HIS P 131
ASN P  93
 None
 1.14A 3nneG-6g2jP:
undetectable		 3nneG-6g2jP:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsa -

(-) 		no annotation 4 ILE E  94
HIS E 158
VAL E 154
HIS E  86
 None
 1.20A 3nneG-6gsaE:
undetectable		 3nneG-6gsaE:
undetectable