SIMILAR PATTERNS OF AMINO ACIDS FOR 3NN0_X_NCAX433

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		7 TYR A  59
ASN A 166
MET A 167
LEU A 183
PHE A 326
TRP A 371
GLY A 406
 None
None
None
None
None
None
FAD  A 434 (-4.3A)
 0.65A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		7 TYR A  59
ASN A 166
MET A 167
PHE A 326
TRP A 371
GLY A 406
TYR A 407
 None
None
None
None
None
FAD  A 434 (-4.3A)
FAD  A 434 (-4.3A)
 0.78A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		7 TYR A  59
MET A 167
LEU A 183
LEU A 198
PHE A 326
TRP A 371
GLY A 406
 None
None
None
None
None
None
FAD  A 434 (-4.3A)
 0.81A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3k7t 6-HYDROXY-L-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01593
(Amino_oxidase) 		7 TYR A  59
MET A 167
LEU A 198
PHE A 326
TRP A 371
GLY A 406
TYR A 407
 None
None
None
None
None
FAD  A 434 (-4.3A)
FAD  A 434 (-4.3A)
 0.87A 3nn0X-3k7tA:
64.4		 3nn0X-3k7tA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3krn PROTEIN C14A4.5,
CONFIRMED BY
TRANSCRIPT EVIDENCE

(Caenorhabditis
elegans) 		PF01138
(RNase_PH) 		5 ASN A 110
LEU A 131
LEU A   5
PHE A  24
GLY A 102
 None
 1.27A 3nn0X-3krnA:
0.0		 3nn0X-3krnA:
19.95