SIMILAR PATTERNS OF AMINO ACIDS FOR 3NLY_A_H4BA760

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c4k PROTEIN (ORNITHINE
DECARBOXYLASE)


(Lactobacillus
sp. 30A)
PF01276
(OKR_DC_1)
PF03709
(OKR_DC_1_N)
PF03711
(OKR_DC_1_C)
4 VAL A 667
TRP A 673
PHE A 681
GLU A 649
None
1.30A 3nlyA-1c4kA:
0.0
3nlyB-1c4kA:
0.0
3nlyA-1c4kA:
19.07
3nlyB-1c4kA:
19.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cyo CYTOCHROME B5

(Bos taurus)
PF00173
(Cyt-b5)
4 ARG A  68
VAL A  61
PHE A  58
GLU A  56
None
None
HEM  A 201 (-4.8A)
None
1.39A 3nlyA-1cyoA:
0.0
3nlyB-1cyoA:
0.0
3nlyA-1cyoA:
12.05
3nlyB-1cyoA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhu O-SUCCINYLBENZOATE
SYNTHASE


(Escherichia
coli)
PF13378
(MR_MLE_C)
4 ARG A   2
VAL A  87
TRP A  66
GLU A  76
None
1.46A 3nlyA-1fhuA:
0.8
3nlyB-1fhuA:
0.0
3nlyA-1fhuA:
25.23
3nlyB-1fhuA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kex NEUROPILIN-1

(Homo sapiens)
PF00754
(F5_F8_type_C)
4 ARG A 130
TRP A  97
PHE A 131
GLU A  95
None
1.45A 3nlyA-1kexA:
undetectable
3nlyB-1kexA:
0.0
3nlyA-1kexA:
16.83
3nlyB-1kexA:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kh2 ARGININOSUCCINATE
SYNTHETASE


(Thermus
thermophilus)
PF00764
(Arginosuc_synth)
4 ARG A 282
VAL A 226
PHE A 220
GLU A 222
None
1.34A 3nlyA-1kh2A:
0.0
3nlyB-1kh2A:
0.1
3nlyA-1kh2A:
22.65
3nlyB-1kh2A:
22.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5j ACONITATE HYDRATASE
2


(Escherichia
coli)
PF00330
(Aconitase)
PF06434
(Aconitase_2_N)
PF11791
(Aconitase_B_N)
4 ARG A 340
TRP A 155
PHE A 156
GLU A 154
None
1.31A 3nlyA-1l5jA:
undetectable
3nlyB-1l5jA:
0.0
3nlyA-1l5jA:
19.28
3nlyB-1l5jA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhz METHANE
MONOOXYGENASE
HYDROXYLASE


(Methylosinus
trichosporium)
PF02332
(Phenol_Hydrox)
4 VAL D  28
TRP D  31
PHE D  35
GLU D 132
None
1.44A 3nlyA-1mhzD:
0.0
3nlyB-1mhzD:
0.0
3nlyA-1mhzD:
20.85
3nlyB-1mhzD:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mzb FERRIC UPTAKE
REGULATION PROTEIN


(Pseudomonas
aeruginosa)
PF01475
(FUR)
4 ARG A  69
VAL A  54
PHE A  79
GLU A  36
None
1.07A 3nlyA-1mzbA:
0.2
3nlyB-1mzbA:
0.7
3nlyA-1mzbA:
16.59
3nlyB-1mzbA:
16.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1j HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa)
PF09152
(DUF1937)
4 ARG A   2
VAL A  28
TRP A 110
PHE A 117
None
1.48A 3nlyA-1t1jA:
0.0
3nlyB-1t1jA:
0.0
3nlyA-1t1jA:
16.38
3nlyB-1t1jA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tki TITIN

(Homo sapiens)
PF00069
(Pkinase)
4 VAL A 122
TRP A 277
PHE A 254
GLU A 250
None
1.46A 3nlyA-1tkiA:
undetectable
3nlyB-1tkiA:
undetectable
3nlyA-1tkiA:
20.23
3nlyB-1tkiA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vmk PURINE NUCLEOSIDE
PHOSPHORYLASE


(Thermotoga
maritima)
PF01048
(PNP_UDP_1)
4 VAL A 221
TRP A 162
PHE A 265
GLU A 161
None
1.45A 3nlyA-1vmkA:
undetectable
3nlyB-1vmkA:
undetectable
3nlyA-1vmkA:
21.48
3nlyB-1vmkA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wql ETHYLBENZENE
DIOXYGENASE SMALL
SUBUNIT


(Pseudomonas
fluorescens)
PF00866
(Ring_hydroxyl_B)
4 ARG B 156
VAL B 128
PHE B 163
GLU B  26
None
1.18A 3nlyA-1wqlB:
undetectable
3nlyB-1wqlB:
undetectable
3nlyA-1wqlB:
19.79
3nlyB-1wqlB:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus)
PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl)
4 ARG A 708
VAL A1424
PHE A 722
GLU A 693
None
1.14A 3nlyA-2b39A:
undetectable
3nlyB-2b39A:
undetectable
3nlyA-2b39A:
13.58
3nlyB-2b39A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 ARG A 586
VAL A 578
TRP A 579
GLU A 555
None
1.20A 3nlyA-2fjaA:
undetectable
3nlyB-2fjaA:
undetectable
3nlyA-2fjaA:
22.29
3nlyB-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A
ADENYLYLSULFATE
REDUCTASE, SUBUNIT B


(Archaeoglobus
fulgidus)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  62
VAL A 367
TRP B 788
GLU A 360
None
1.38A 3nlyA-2fjaA:
undetectable
3nlyB-2fjaA:
undetectable
3nlyA-2fjaA:
22.29
3nlyB-2fjaA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9u CYTOSINE/GUANINE
DEAMINASE RELATED
PROTEIN


(Clostridium
acetobutylicum)
PF01979
(Amidohydro_1)
4 ARG A 202
TRP A  93
PHE A  99
GLU A 101
GUN  A 503 (-3.7A)
None
None
None
1.28A 3nlyA-2i9uA:
undetectable
3nlyB-2i9uA:
0.4
3nlyA-2i9uA:
20.97
3nlyB-2i9uA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2noz N-GLYCOSYLASE/DNA
LYASE


(Homo sapiens)
PF00730
(HhH-GPD)
PF07934
(OGG_N)
4 VAL A 267
TRP A 272
PHE A 303
GLU A 298
None
1.06A 3nlyA-2nozA:
undetectable
3nlyB-2nozA:
undetectable
3nlyA-2nozA:
22.30
3nlyB-2nozA:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rik TITIN

(Oryctolagus
cuniculus)
PF07679
(I-set)
4 VAL A 127
TRP A 129
PHE A  97
GLU A 116
None
1.35A 3nlyA-2rikA:
undetectable
3nlyB-2rikA:
undetectable
3nlyA-2rikA:
22.52
3nlyB-2rikA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w4o CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE IV


(Homo sapiens)
PF00069
(Pkinase)
4 ARG A 278
VAL A 269
TRP A 266
PHE A 261
None
1.46A 3nlyA-2w4oA:
1.4
3nlyB-2w4oA:
undetectable
3nlyA-2w4oA:
20.26
3nlyB-2w4oA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus)
PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110)
4 ARG A 697
VAL A 717
PHE A 698
GLU A 722
None
1.35A 3nlyA-2xvgA:
undetectable
3nlyB-2xvgA:
0.6
3nlyA-2xvgA:
19.68
3nlyB-2xvgA:
19.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywb GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]


(Thermus
thermophilus)
PF00117
(GATase)
PF00958
(GMP_synt_C)
4 ARG A 211
VAL A 239
PHE A 309
GLU A 305
None
1.35A 3nlyA-2ywbA:
undetectable
3nlyB-2ywbA:
undetectable
3nlyA-2ywbA:
21.54
3nlyB-2ywbA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z11 RIBOSOMAL-PROTEIN-AL
ANINE
ACETYLTRANSFERASE


(Thermus
thermophilus)
PF13302
(Acetyltransf_3)
4 VAL A  64
TRP A  66
PHE A   4
GLU A   6
None
1.42A 3nlyA-2z11A:
undetectable
3nlyB-2z11A:
undetectable
3nlyA-2z11A:
17.58
3nlyB-2z11A:
17.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpk IGG1-LAMBDA P20.1
FAB (HEAVY CHAIN)


(Mus musculus)
PF07654
(C1-set)
PF07686
(V-set)
4 VAL H  37
TRP H  47
PHE H  69
GLU H  95
None
1.36A 3nlyA-2zpkH:
undetectable
3nlyB-2zpkH:
undetectable
3nlyA-2zpkH:
20.10
3nlyB-2zpkH:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b7f GLYCOSYL HYDROLASE,
BNR REPEAT


(Cupriavidus
pinatubonensis)
no annotation 4 VAL A 314
TRP A 293
TRP A 374
GLU A 372
None
None
None
EDO  A 404 ( 3.8A)
1.47A 3nlyA-3b7fA:
undetectable
3nlyB-3b7fA:
undetectable
3nlyA-3b7fA:
20.87
3nlyB-3b7fA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ddl XANTHORHODOPSIN

(Salinibacter
ruber)
PF01036
(Bac_rhodopsin)
4 VAL A  16
TRP A  70
PHE A  88
GLU A  71
None
1.46A 3nlyA-3ddlA:
undetectable
3nlyB-3ddlA:
undetectable
3nlyA-3ddlA:
20.14
3nlyB-3ddlA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs3 SYMPLEKIN

(Drosophila
melanogaster)
PF11935
(DUF3453)
4 ARG A  27
VAL A  56
PHE A  67
GLU A  65
None
1.50A 3nlyA-3gs3A:
undetectable
3nlyB-3gs3A:
undetectable
3nlyA-3gs3A:
20.28
3nlyB-3gs3A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyx ADENYLYLSULFATE
REDUCTASE


(Desulfovibrio
gigas)
PF00890
(FAD_binding_2)
PF12139
(APS-reductase_C)
PF13187
(Fer4_9)
4 ARG A  66
VAL A 387
TRP B  88
GLU A 380
None
1.33A 3nlyA-3gyxA:
undetectable
3nlyB-3gyxA:
undetectable
3nlyA-3gyxA:
20.98
3nlyB-3gyxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1


(Toxoplasma
gondii)
PF00069
(Pkinase)
4 ARG A 269
VAL A 260
TRP A 257
PHE A 252
None
1.44A 3nlyA-3ma6A:
undetectable
3nlyB-3ma6A:
undetectable
3nlyA-3ma6A:
21.55
3nlyB-3ma6A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owc PROBABLE
ACETYLTRANSFERASE


(Pseudomonas
aeruginosa)
PF00583
(Acetyltransf_1)
4 ARG A 175
VAL A  92
PHE A 121
GLU A 119
None
1.21A 3nlyA-3owcA:
undetectable
3nlyB-3owcA:
undetectable
3nlyA-3owcA:
16.47
3nlyB-3owcA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qld MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN


(Alicyclobacillus
acidocaldarius)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 ARG A 328
VAL A 167
PHE A 164
GLU A 161
None
1.38A 3nlyA-3qldA:
undetectable
3nlyB-3qldA:
0.2
3nlyA-3qldA:
21.06
3nlyB-3qldA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A


(Fervidobacterium
nodosum)
PF00150
(Cellulase)
4 VAL A 149
TRP A 146
PHE A 162
GLU A 187
None
1.32A 3nlyA-3rjyA:
1.3
3nlyB-3rjyA:
undetectable
3nlyA-3rjyA:
21.27
3nlyB-3rjyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus)
PF00064
(Neur)
4 VAL A 240
TRP A 239
PHE A 305
GLU A 265
None
1.35A 3nlyA-3ti8A:
undetectable
3nlyB-3ti8A:
undetectable
3nlyA-3ti8A:
22.64
3nlyB-3ti8A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqu NON-CANONICAL PURINE
NTP PYROPHOSPHATASE


(Coxiella
burnetii)
PF01725
(Ham1p_like)
4 VAL A 162
TRP A 140
PHE A 118
GLU A 141
None
1.25A 3nlyA-3tquA:
undetectable
3nlyB-3tquA:
undetectable
3nlyA-3tquA:
19.05
3nlyB-3tquA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa)
PF02223
(Thymidylate_kin)
4 ARG A 109
VAL A 166
PHE A 162
GLU A 156
None
None
None
MG  A 213 (-3.2A)
1.33A 3nlyA-3uxmA:
undetectable
3nlyB-3uxmA:
undetectable
3nlyA-3uxmA:
20.29
3nlyB-3uxmA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wa1 BINB PROTEIN

(Lysinibacillus
sphaericus)
PF05431
(Toxin_10)
4 ARG A 388
VAL A 385
PHE A 311
GLU A 267
None
1.47A 3nlyA-3wa1A:
undetectable
3nlyB-3wa1A:
undetectable
3nlyA-3wa1A:
22.22
3nlyB-3wa1A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bgd PRE-MRNA-SPLICING
FACTOR 8


(Saccharomyces
cerevisiae)
PF08084
(PROCT)
4 VAL C2274
TRP C2314
PHE C2329
GLU C2310
None
1.32A 3nlyA-4bgdC:
undetectable
3nlyB-4bgdC:
undetectable
3nlyA-4bgdC:
20.99
3nlyB-4bgdC:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB


(Geobacillus
stearothermophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
4 ARG A 373
VAL A 412
TRP A 383
PHE A 370
None
1.48A 3nlyA-4fnqA:
undetectable
3nlyB-4fnqA:
undetectable
3nlyA-4fnqA:
20.73
3nlyB-4fnqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxq PUTATIVE
ADP-RIBOSYLTRANSFERA
SE CERTHRAX


(Bacillus cereus)
PF03496
(ADPrib_exo_Tox)
PF07737
(ATLF)
4 ARG A 160
VAL A 178
PHE A 164
GLU A 189
None
1.49A 3nlyA-4fxqA:
undetectable
3nlyB-4fxqA:
undetectable
3nlyA-4fxqA:
22.02
3nlyB-4fxqA:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori)
PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C)
4 VAL B 351
TRP B 355
PHE B 327
GLU B 424
None
1.01A 3nlyA-4l37B:
undetectable
3nlyB-4l37B:
undetectable
3nlyA-4l37B:
20.69
3nlyB-4l37B:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mh1 SORBOSE
DEHYDROGENASE


(Ketogulonicigenium
vulgare)
PF13360
(PQQ_2)
4 ARG A 385
TRP A 387
TRP A 218
PHE A 286
None
1.35A 3nlyA-4mh1A:
undetectable
3nlyB-4mh1A:
undetectable
3nlyA-4mh1A:
21.16
3nlyB-4mh1A:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pne METHYLTRANSFERASE-LI
KE PROTEIN


(Saccharopolyspora
spinosa)
PF08241
(Methyltransf_11)
4 ARG A  75
VAL A  79
PHE A 141
GLU A 162
None
1.41A 3nlyA-4pneA:
undetectable
3nlyB-4pneA:
undetectable
3nlyA-4pneA:
21.36
3nlyB-4pneA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 ARG A 276
VAL A 305
PHE A 264
GLU A 266
None
1.09A 3nlyA-4xj6A:
undetectable
3nlyB-4xj6A:
undetectable
3nlyA-4xj6A:
21.06
3nlyB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xj6 VC0179-LIKE PROTEIN

(Escherichia
coli)
no annotation 4 VAL A 305
TRP A 263
PHE A 264
GLU A 266
None
1.10A 3nlyA-4xj6A:
undetectable
3nlyB-4xj6A:
undetectable
3nlyA-4xj6A:
21.06
3nlyB-4xj6A:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ylr TUBULIN
POLYGLUTAMYLASE
TTLL7


(Homo sapiens)
PF03133
(TTL)
4 VAL A 288
TRP A 292
PHE A 277
GLU A 279
None
1.43A 3nlyA-4ylrA:
undetectable
3nlyB-4ylrA:
undetectable
3nlyA-4ylrA:
22.81
3nlyB-4ylrA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bs1 CRRBCX-IIA

(Chlamydomonas
reinhardtii)
PF02341
(RcbX)
4 ARG A 123
VAL A 108
TRP A 104
GLU A 103
ARG  A 123 ( 0.6A)
VAL  A 108 ( 0.6A)
TRP  A 104 ( 0.5A)
GLU  A 103 ( 0.6A)
1.31A 3nlyA-5bs1A:
undetectable
3nlyB-5bs1A:
undetectable
3nlyA-5bs1A:
14.45
3nlyB-5bs1A:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by3 BTGH115A

(Bacteroides
thetaiotaomicron)
PF15979
(Glyco_hydro_115)
4 ARG A 505
VAL A 736
TRP A 732
GLU A 731
None
1.38A 3nlyA-5by3A:
undetectable
3nlyB-5by3A:
undetectable
3nlyA-5by3A:
19.82
3nlyB-5by3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c6g AGR133CP
SISTER CHROMATID
COHESION PROTEIN 2


(Eremothecium
gossypii)
PF10345
(Cohesin_load)
no annotation
4 VAL B  28
TRP A 401
PHE A 397
GLU A 402
None
1.45A 3nlyA-5c6gB:
undetectable
3nlyB-5c6gB:
undetectable
3nlyA-5c6gB:
18.69
3nlyB-5c6gB:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kqi CATALASE-PEROXIDASE

(Burkholderia
pseudomallei)
PF00141
(peroxidase)
4 VAL A 481
TRP A 736
PHE A 732
GLU A 560
None
1.50A 3nlyA-5kqiA:
undetectable
3nlyB-5kqiA:
undetectable
3nlyA-5kqiA:
20.85
3nlyB-5kqiA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
4 ARG A 225
TRP A 414
PHE A 411
GLU A 413
None
1.03A 3nlyA-5m8tA:
undetectable
3nlyB-5m8tA:
undetectable
3nlyA-5m8tA:
20.00
3nlyB-5m8tA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xct VH(S112C)-SARAH
CHIMERA


(Homo sapiens;
Mus musculus)
PF07686
(V-set)
PF11629
(Mst1_SARAH)
4 VAL A  37
TRP A  47
PHE A  69
GLU A  95
None
1.38A 3nlyA-5xctA:
undetectable
3nlyB-5xctA:
undetectable
3nlyA-5xctA:
16.71
3nlyB-5xctA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xf7 PROTEIN
DISULFIDE-ISOMERASE-
LIKE PROTEIN OF THE
TESTIS


(Homo sapiens)
no annotation 4 ARG A 129
VAL A  65
PHE A 113
GLU A 106
None
1.21A 3nlyA-5xf7A:
undetectable
3nlyB-5xf7A:
undetectable
3nlyA-5xf7A:
10.85
3nlyB-5xf7A:
10.85