SIMILAR PATTERNS OF AMINO ACIDS FOR 3NK7_B_SAMB770_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuk EUKARYOTIC
INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		6 ASN A 333
LEU A 319
ILE A 289
MET A 302
LEU A 313
SER A 315
 None
 1.44A 3nk7B-1fukA:
undetectable		 3nk7B-1fukA:
20.07
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		7 ASN A 108
GLY A 196
GLY A 201
ILE A 216
MET A 218
LEU A 225
VAL A 227
 None
 0.70A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		6 ASN A 108
GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
 None
 1.23A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		6 ASN A 108
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.72A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gz0 HYPOTHETICAL
TRNA/RRNA
METHYLTRANSFERASE
YJFH

(Escherichia
coli) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		6 GLY A 199
ILE A 216
MET A 218
SER A 224
LEU A 225
VAL A 227
 None
 0.70A 3nk7B-1gz0A:
22.0		 3nk7B-1gz0A:
30.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		8 ASN A 129
GLY A 215
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
SER A 249
 None
 0.71A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		7 ASN A 129
LEU A 253
ILE A 235
MET A 237
LEU A 244
VAL A 246
SER A 249
 None
 1.43A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ipa RNA 2'-O-RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		8 GLY A 215
GLY A 220
ILE A 235
MET A 237
SER A 243
LEU A 244
VAL A 246
SER A 249
 None
 0.89A 3nk7B-1ipaA:
21.0		 3nk7B-1ipaA:
28.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		9 ASN A  14
LEU A  78
PHE A  99
GLY A 100
GLY A 105
ILE A 122
MET A 124
SER A 130
SER A 136
 None
 0.99A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		6 GLY A 100
GLU A 102
GLY A 105
ILE A 122
MET A 124
SER A 130
 None
 1.30A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j85 YIBK

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		6 LEU A  78
PHE A  99
GLY A 100
GLU A  10
GLY A 105
SER A 136
 None
 1.33A 3nk7B-1j85A:
17.0		 3nk7B-1j85A:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kut PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Thermotoga
maritima) 		PF01259
(SAICAR_synt) 		5 LEU A 183
PHE A 173
GLY A 174
ILE A  59
VAL A 181
 None
 1.00A 3nk7B-1kutA:
undetectable		 3nk7B-1kutA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3p LECTIN PAL

(Pterocarpus
angolensis) 		PF00139
(Lectin_legB) 		6 LEU A 108
GLY A 105
GLY A 220
ILE A  88
LEU A  33
VAL A  47
 None
GLC  A 253 ( 3.8A)
GLC  A 253 (-3.1A)
None
None
None
 1.46A 3nk7B-1n3pA:
undetectable		 3nk7B-1n3pA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz4 HYPOTHETICAL PROTEIN
YCFC

(Escherichia
coli) 		PF04356
(DUF489) 		5 PHE A  55
GLY A  56
ILE A  43
LEU A  40
VAL A  38
 None
 0.93A 3nk7B-1qz4A:
undetectable		 3nk7B-1qz4A:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		9 ASN A  35
PHE A 121
GLY A 122
GLY A 127
ILE A 142
MET A 144
SER A 150
LEU A 151
VAL A 153
 PO4  A 201 (-3.4A)
SAM  A 400 (-4.6A)
SAM  A 400 (-3.2A)
SAM  A 400 (-3.8A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.3A)
SAM  A 400 ( 3.7A)
SAM  A 400 (-4.0A)
SAM  A 400 (-3.9A)
 0.60A 3nk7B-1v2xA:
18.8		 3nk7B-1v2xA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		7 GLY A 122
GLU A 124
GLY A 127
ILE A 142
MET A 144
SER A 150
LEU A 151
 SAM  A 400 (-3.2A)
PO4  A 201 ( 4.6A)
SAM  A 400 (-3.8A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.3A)
SAM  A 400 ( 3.7A)
SAM  A 400 (-4.0A)
 1.14A 3nk7B-1v2xA:
18.8		 3nk7B-1v2xA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v2x TRNA (GM18)
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		5 GLY A 122
ILE A 142
MET A 144
SER A 150
LEU A 151
 SAM  A 400 (-3.2A)
SAM  A 400 (-3.6A)
SAM  A 400 (-3.3A)
SAM  A 400 ( 3.7A)
SAM  A 400 (-4.0A)
 0.89A 3nk7B-1v2xA:
18.8		 3nk7B-1v2xA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vhk HYPOTHETICAL PROTEIN
YQEU

(Bacillus
subtilis) 		PF04452
(Methyltrans_RNA) 		5 PHE A 203
GLY A 204
GLU A 206
GLY A 208
LEU A 232
 None
 0.86A 3nk7B-1vhkA:
13.1		 3nk7B-1vhkA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vqv THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		5 LEU A 256
PHE A 257
GLY A 258
GLY A 158
ILE A 229
 None
 0.92A 3nk7B-1vqvA:
undetectable		 3nk7B-1vqvA:
23.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		7 ASN A 139
GLY A 232
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
 None
SAM  A 301 (-3.2A)
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 0.84A 3nk7B-1x7pA:
24.6		 3nk7B-1x7pA:
30.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1x7p RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF00588
(SpoU_methylase) 		7 GLY A 232
GLU A 234
GLY A 237
ILE A 252
MET A 254
SER A 260
LEU A 261
 SAM  A 301 (-3.2A)
None
SAM  A 301 (-3.4A)
SAM  A 301 (-4.0A)
SAM  A 301 (-3.1A)
SAM  A 301 ( 3.7A)
SAM  A 301 (-4.1A)
 1.14A 3nk7B-1x7pA:
24.6		 3nk7B-1x7pA:
30.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z5v TUBULIN GAMMA-1
CHAIN

(Homo sapiens) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		5 ASN A 417
GLY A 148
GLU A 155
GLY A 150
LEU A 192
 None
 0.98A 3nk7B-1z5vA:
undetectable		 3nk7B-1z5vA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		7 ASN A  38
GLY A 126
GLY A 131
MET A 148
SER A 154
LEU A 155
VAL A 157
 None
GOL  A 529 (-4.0A)
GOL  A 530 (-3.7A)
None
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.7A)
 0.79A 3nk7B-1zjrA:
17.4		 3nk7B-1zjrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zjr TRNA
(GUANOSINE-2'-O-)-ME
THYLTRANSFERASE

(Aquifex
aeolicus) 		PF00588
(SpoU_methylase)
PF12105
(SpoU_methylas_C) 		7 ASN A  38
GLY A 126
ILE A 146
MET A 148
SER A 154
LEU A 155
VAL A 157
 None
GOL  A 529 (-4.0A)
None
None
GOL  A 529 (-3.5A)
None
GOL  A 529 (-3.7A)
 0.63A 3nk7B-1zjrA:
17.4		 3nk7B-1zjrA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e55 URACIL
PHOSPHORIBOSYLTRANSF
ERASE

(Aquifex
aeolicus) 		PF14681
(UPRTase) 		5 LEU A  34
PHE A  82
GLY A  85
ILE A  10
VAL A  39
 None
 0.97A 3nk7B-2e55A:
undetectable		 3nk7B-2e55A:
25.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gqs PHOSPHORIBOSYLAMINOI
MIDAZOLE-SUCCINOCARB
OXAMIDE SYNTHASE

(Escherichia
coli) 		PF01259
(SAICAR_synt) 		5 ASN A 147
LEU A 189
PHE A 180
GLY A 181
VAL A 187
 None
 0.96A 3nk7B-2gqsA:
undetectable		 3nk7B-2gqsA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 GLY A2970
GLY A2969
ILE A2810
SER A2965
SER A2976
 P6G  A1000 (-3.5A)
P6G  A1000 (-3.2A)
None
None
None
 0.98A 3nk7B-2h84A:
undetectable		 3nk7B-2h84A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN

(Homo sapiens) 		PF00588
(SpoU_methylase) 		8 ASN A  39
GLY A 129
GLY A 134
ILE A 149
SER A 157
LEU A 158
VAL A 160
SER A 163
 None
SAH  A 401 (-3.1A)
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 0.48A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN

(Homo sapiens) 		PF00588
(SpoU_methylase) 		6 ASN A  39
LEU A 167
ILE A 149
LEU A 158
VAL A 160
SER A 163
 None
None
SAH  A 401 (-3.8A)
SAH  A 401 (-4.3A)
SAH  A 401 (-3.6A)
SAH  A 401 (-3.0A)
 1.34A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ha8 TAR (HIV-1) RNA LOOP
BINDING PROTEIN

(Homo sapiens) 		PF00588
(SpoU_methylase) 		6 GLY A 129
GLU A 131
GLY A 134
ILE A 149
SER A 157
LEU A 158
 SAH  A 401 (-3.1A)
None
SAH  A 401 (-3.2A)
SAH  A 401 (-3.8A)
SAH  A 401 ( 3.8A)
SAH  A 401 (-4.3A)
 0.96A 3nk7B-2ha8A:
18.7		 3nk7B-2ha8A:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6d RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Porphyromonas
gingivalis) 		PF00588
(SpoU_methylase) 		6 ASN A 113
GLY A 203
GLY A 208
ILE A 223
LEU A 237
VAL A 239
 ACY  A 301 (-4.0A)
None
None
None
None
None
 0.47A 3nk7B-2i6dA:
22.8		 3nk7B-2i6dA:
28.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kv1 METHIONINE-R-SULFOXI
DE REDUCTASE B1

(Mus musculus) 		PF01641
(SelR) 		5 GLY A  75
GLY A  72
ILE A  96
LEU A 101
SER A 100
 None
 0.99A 3nk7B-2kv1A:
undetectable		 3nk7B-2kv1A:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mhc TNPX

(Clostridium
perfringens) 		PF00239
(Resolvase) 		5 ASN A  90
LEU A 101
PHE A  96
GLY A  95
ILE A  68
 None
 0.93A 3nk7B-2mhcA:
undetectable		 3nk7B-2mhcA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ox4 PUTATIVE MANDELATE
RACEMASE

(Zymomonas
mobilis) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 318
GLU A 340
ILE A  98
SER A 326
LEU A 289
 None
 0.93A 3nk7B-2ox4A:
undetectable		 3nk7B-2ox4A:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qmm UPF0217 PROTEIN
AF_1056

(Archaeoglobus
fulgidus) 		PF04013
(Methyltrn_RNA_2) 		5 LEU A 221
GLY A 242
GLY A 246
SER A 269
LEU A 270
 SAM  A 301 (-4.3A)
SAM  A 301 (-3.6A)
SAM  A 301 (-3.3A)
SAM  A 301 (-4.1A)
SAM  A 301 (-4.5A)
 0.94A 3nk7B-2qmmA:
10.7		 3nk7B-2qmmA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdc GLUTAMATE SYNTHASE
[NADPH] LARGE CHAIN

(Azospirillum
brasilense) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 LEU A1259
PHE A1254
GLY A1255
ILE A1264
LEU A1246
 None
 0.93A 3nk7B-2vdcA:
undetectable		 3nk7B-2vdcA:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xh1 KYNURENINE/ALPHA-AMI
NOADIPATE
AMINOTRANSFERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 PHE A 273
GLY A 272
GLY A 116
ILE A 264
SER A 266
 None
None
PLP  A1427 ( 3.8A)
None
None
 1.01A 3nk7B-2xh1A:
undetectable		 3nk7B-2xh1A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c9r THIAMINE
MONOPHOSPHATE KINASE

(Aquifex
aeolicus) 		PF00586
(AIRS) 		5 LEU A 256
PHE A 257
GLY A 258
GLY A 158
ILE A 229
 None
 0.89A 3nk7B-3c9rA:
undetectable		 3nk7B-3c9rA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		6 ASN A 114
LEU A  91
GLU A  65
GLY A  68
ILE A  42
VAL A  61
 None
None
CA  A 401 (-2.0A)
None
None
None
 1.27A 3nk7B-3cdxA:
undetectable		 3nk7B-3cdxA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cdx SUCCINYLGLUTAMATEDES
UCCINYLASE/ASPARTOAC
YLASE

(Rhodobacter
sphaeroides) 		PF04952
(AstE_AspA) 		6 ASN A 114
LEU A  91
GLY A  59
GLU A  65
GLY A  68
VAL A  61
 None
None
None
CA  A 401 (-2.0A)
None
None
 1.48A 3nk7B-3cdxA:
undetectable		 3nk7B-3cdxA:
24.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcm UNCHARACTERIZED
PROTEIN TM_1570

(Thermotoga
maritima) 		PF09936
(Methyltrn_RNA_4) 		5 GLY X 141
GLY X 145
ILE X 161
LEU X 170
VAL X 172
 SAM  X5452 (-3.1A)
SAM  X5452 (-3.7A)
SAM  X5452 (-3.7A)
SAM  X5452 (-4.2A)
SAM  X5452 (-3.7A)
 0.47A 3nk7B-3dcmX:
14.2		 3nk7B-3dcmX:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5y TRMH FAMILY RNA
METHYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF00588
(SpoU_methylase) 		6 ASN A  14
PHE A 101
GLY A 102
GLY A 107
MET A 126
LEU A 133
 None
 0.68A 3nk7B-3e5yA:
15.9		 3nk7B-3e5yA:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e5y TRMH FAMILY RNA
METHYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF00588
(SpoU_methylase) 		6 ASN A  14
PHE A 101
GLY A 102
MET A 126
SER A 132
LEU A 133
 None
 0.86A 3nk7B-3e5yA:
15.9		 3nk7B-3e5yA:
23.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		8 ASN A 129
GLY A 218
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
 None
SAM  A 270 (-2.9A)
None
SAM  A 270 (-3.5A)
SAM  A 270 (-3.5A)
SAM  A 270 (-2.8A)
SAM  A 270 (-4.4A)
SAM  A 270 ( 4.2A)
 0.92A 3nk7B-3gyqA:
30.7		 3nk7B-3gyqA:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		10 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLY A 223
ILE A 238
MET A 240
LEU A 247
VAL A 249
SER A 252
 None
SAM  A 270 (-4.1A)
None
SAM  A 270 (-2.9A)
None
SAM  A 270 (-3.5A)
SAM  A 270 (-3.5A)
SAM  A 270 (-4.4A)
SAM  A 270 ( 4.2A)
SAM  A 270 (-3.1A)
 0.61A 3nk7B-3gyqA:
30.7		 3nk7B-3gyqA:
73.53
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gyq RRNA
(ADENOSINE-2'-O-)-ME
THYLTRANSFERASE

(Streptomyces
cyaneus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		6 LEU A 195
PHE A 217
GLU A 220
ILE A 238
MET A 240
SER A 252
 SAM  A 270 (-4.1A)
None
None
SAM  A 270 (-3.5A)
SAM  A 270 (-3.5A)
SAM  A 270 (-3.1A)
 1.06A 3nk7B-3gyqA:
30.7		 3nk7B-3gyqA:
73.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hd6 AMMONIUM TRANSPORTER
RH TYPE C

(Homo sapiens) 		PF00909
(Ammonium_transp) 		6 PHE A 311
GLY A 310
GLY A 289
ILE A 267
SER A 317
VAL A 312
 None
None
None
None
None
BOG  A 501 ( 4.4A)
 1.26A 3nk7B-3hd6A:
undetectable		 3nk7B-3hd6A:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		5 PHE A 493
GLY A 494
ILE A 484
SER A 362
LEU A 365
 None
 0.94A 3nk7B-3hztA:
undetectable		 3nk7B-3hztA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		6 ASN A  27
LEU A 109
PHE A 144
GLY A 145
GLY A 150
ILE A 165
 None
 0.88A 3nk7B-3ic6A:
14.0		 3nk7B-3ic6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ic6 PUTATIVE METHYLASE
FAMILY PROTEIN

(Neisseria
gonorrhoeae) 		PF00588
(SpoU_methylase) 		6 ASN A  27
PHE A 144
GLY A 145
GLY A 150
ILE A 165
LEU A 174
 None
 0.72A 3nk7B-3ic6A:
14.0		 3nk7B-3ic6A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijd UNCHARACTERIZED
PROTEIN

(Ruminiclostridium
thermocellum) 		PF02219
(MTHFR) 		6 ASN A 251
LEU A 216
ILE A 260
LEU A 256
VAL A 254
SER A 257
 None
 1.47A 3nk7B-3ijdA:
3.7		 3nk7B-3ijdA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ilk UNCHARACTERIZED
TRNA/RRNA
METHYLTRANSFERASE
HI0380

(Haemophilus
influenzae) 		PF00588
(SpoU_methylase) 		7 ASN A  17
PHE A 110
GLY A 111
GLY A 116
ILE A 131
SER A 139
LEU A 140
 None
None
EDO  A 242 (-4.6A)
None
EDO  A 243 (-4.0A)
None
None
 0.76A 3nk7B-3ilkA:
15.9		 3nk7B-3ilkA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jro FUSION PROTEIN OF
PROTEIN TRANSPORT
PROTEIN SEC13 AND
NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12110
(Nup96) 		6 LEU A1498
GLU A1194
ILE A1508
LEU A1492
VAL A1494
SER A1495
 None
 1.50A 3nk7B-3jroA:
undetectable		 3nk7B-3jroA:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE

(Bordetella
pertussis) 		PF00588
(SpoU_methylase) 		7 ASN A  20
GLY A 123
GLY A 128
ILE A 143
SER A 151
LEU A 152
VAL A 154
 None
 0.84A 3nk7B-3ktyA:
17.6		 3nk7B-3ktyA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE

(Bordetella
pertussis) 		PF00588
(SpoU_methylase) 		7 ASN A  20
LEU A  85
GLY A 123
GLY A 128
ILE A 143
SER A 151
VAL A 154
 None
 0.73A 3nk7B-3ktyA:
17.6		 3nk7B-3ktyA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans) 		PF00588
(SpoU_methylase) 		7 ASN A  30
PHE A 116
GLY A 117
GLY A 122
ILE A 138
SER A 147
LEU A 148
 None
 0.73A 3nk7B-3l8uA:
16.4		 3nk7B-3l8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8u PUTATIVE RRNA
METHYLASE

(Streptococcus
mutans) 		PF00588
(SpoU_methylase) 		5 GLY A 117
GLU A 119
GLY A 122
SER A 147
LEU A 148
 None
 0.97A 3nk7B-3l8uA:
16.4		 3nk7B-3l8uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		8 ASN A  14
LEU A  83
PHE A 104
GLY A 105
GLY A 110
ILE A 127
MET A 129
SER A 135
 None
SAH  A 201 (-4.1A)
SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
 0.70A 3nk7B-3n4kA:
16.6		 3nk7B-3n4kA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4k RNA
METHYLTRANSFERASE

(Yersinia pestis) 		PF00588
(SpoU_methylase) 		7 LEU A  83
GLY A 105
GLU A 107
GLY A 110
ILE A 127
MET A 129
SER A 135
 SAH  A 201 (-4.1A)
SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.4A)
SAH  A 201 (-3.8A)
SAH  A 201 (-3.4A)
SAH  A 201 (-3.3A)
 1.19A 3nk7B-3n4kA:
16.6		 3nk7B-3n4kA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		12 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
GLY A 223
ILE A 238
MET A 240
SER A 246
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
SAM  A 770 (-3.4A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 0.31A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		9 ASN A 129
LEU A 195
PHE A 217
GLY A 218
GLU A 220
ILE A 255
LEU A 247
VAL A 249
SER A 252
 SAM  A 770 ( 4.1A)
SAM  A 770 (-3.8A)
None
SAM  A 770 (-3.0A)
SAM  A 770 (-4.2A)
None
SAM  A 770 (-4.5A)
SAM  A 770 (-3.7A)
SAM  A 770 (-3.1A)
 1.37A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3nk7 23S RRNA
METHYLTRANSFERASE

(Streptomyces
actuosus) 		PF00588
(SpoU_methylase)
PF04705
(TSNR_N) 		6 GLU A 220
GLY A 218
ILE A 238
MET A 240
SER A 246
LEU A 247
 SAM  A 770 (-4.2A)
SAM  A 770 (-3.0A)
SAM  A 770 (-3.8A)
SAM  A 770 (-3.3A)
SAM  A 770 (-3.9A)
SAM  A 770 (-4.5A)
 0.97A 3nk7B-3nk7A:
37.9		 3nk7B-3nk7A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3onp TRNA/RRNA
METHYLTRANSFERASE
(SPOU)

(Rhodobacter
sphaeroides) 		PF00588
(SpoU_methylase) 		5 ASN A  17
PHE A 115
GLY A 116
GLY A 121
LEU A 145
 CL  A 253 (-4.4A)
None
ACY  A 250 (-4.5A)
ACY  A 250 (-3.5A)
BME  A 251 ( 3.9A)
 0.91A 3nk7B-3onpA:
16.5		 3nk7B-3onpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ryt PLEXIN-A1

(Mus musculus) 		PF08337
(Plexin_cytopl) 		6 ASN A1796
LEU A1771
ILE A1466
MET A1470
SER A1485
VAL A1773
 None
 1.47A 3nk7B-3rytA:
undetectable		 3nk7B-3rytA:
18.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj4 AMPDH2

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF01510
(Amidase_2) 		5 LEU A  98
PHE A  38
GLU A  80
GLY A 104
VAL A  36
 None
 0.91A 3nk7B-4bj4A:
undetectable		 3nk7B-4bj4A:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		5 LEU A  91
PHE A  21
GLU A  73
GLY A  97
VAL A  19
 None
 0.89A 3nk7B-4bxjA:
undetectable		 3nk7B-4bxjA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius) 		PF00588
(SpoU_methylase) 		6 ASN A  15
PHE A 110
GLY A 111
GLY A 116
ILE A 131
LEU A 140
 None
SAH  A1157 (-4.6A)
SAH  A1157 (-3.1A)
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
 0.65A 3nk7B-4cngA:
17.0		 3nk7B-4cngA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cng SPOU RRNA METHYLASE

(Sulfolobus
acidocaldarius) 		PF00588
(SpoU_methylase) 		5 GLY A 111
GLU A 113
GLY A 116
ILE A 131
LEU A 140
 SAH  A1157 (-3.1A)
None
SAH  A1157 ( 3.2A)
SAH  A1157 (-3.6A)
SAH  A1157 (-3.8A)
 0.97A 3nk7B-4cngA:
17.0		 3nk7B-4cngA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwl BBP7

(Bordetella
virus BPP1) 		no annotation 5 PHE A  56
GLY A  60
ILE A 112
LEU A  15
VAL A  17
 None
 0.98A 3nk7B-4dwlA:
undetectable		 3nk7B-4dwlA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4d TUMOR NECROSIS
FACTOR RECEPTOR
SUPERFAMILY MEMBER
11B
TUMOR NECROSIS
FACTOR LIGAND
SUPERFAMILY MEMBER
11, SOLUBLE FORM

(Mus musculus;
Mus musculus) 		PF00020
(TNFR_c6)
PF00229
(TNF) 		5 ASN X 253
GLY X 257
GLU R  95
GLY X 258
SER X 293
 None
 0.91A 3nk7B-4e4dX:
undetectable		 3nk7B-4e4dX:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i99 CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.86A 3nk7B-4i99A:
undetectable		 3nk7B-4i99A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ASN A  14
PHE A  99
GLY A 100
GLY A 105
ILE A 122
MET A 124
 None
 0.58A 3nk7B-4kdzA:
17.0		 3nk7B-4kdzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		6 ASN A  14
PHE A  99
GLY A 100
GLY A 105
ILE A 122
SER A 130
 None
 0.82A 3nk7B-4kdzA:
17.0		 3nk7B-4kdzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdz TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 LEU A  78
PHE A  99
GLY A 100
GLY A 105
SER A 130
 None
 0.84A 3nk7B-4kdzA:
17.0		 3nk7B-4kdzA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		9 ASN A  15
LEU A  79
PHE A 103
GLY A 104
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 None
SAH  A 201 (-4.0A)
SAH  A 201 (-4.9A)
SAH  A 201 (-3.1A)
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.62A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		7 GLY A 104
GLU A 106
GLY A 109
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
None
SAH  A 201 (-3.3A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 1.13A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		5 GLY A 104
ILE A 125
MET A 127
SER A 133
LEU A 134
 SAH  A 201 (-3.1A)
SAH  A 201 (-3.9A)
SAH  A 201 (-3.3A)
SAH  A 201 ( 3.8A)
SAH  A 201 (-4.2A)
 0.75A 3nk7B-4pzkA:
16.5		 3nk7B-4pzkA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wut ABC TRANSPORTER
SUBSTRATE BINDING
PROTEIN (RIBOSE)

(Agrobacterium
vitis) 		PF13407
(Peripla_BP_4) 		5 GLY A 274
GLY A 271
ILE A  29
LEU A  88
VAL A 111
 None
 0.98A 3nk7B-4wutA:
4.7		 3nk7B-4wutA:
25.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		7 ASN A 122
GLY A 208
GLY A 213
ILE A 228
SER A 236
LEU A 237
VAL A 239
 None
ADN  A 301 (-3.1A)
None
ADN  A 301 (-3.8A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.81A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		7 ASN A 122
GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
VAL A 239
 None
ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 0.59A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		6 ASN A 122
LEU A 246
ILE A 228
MET A 230
LEU A 237
VAL A 239
 None
None
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.9A)
ADN  A 301 ( 4.2A)
 1.29A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4x3m RNA 2'-O RIBOSE
METHYLTRANSFERASE

(Thermus
thermophilus) 		PF00588
(SpoU_methylase) 		5 GLY A 208
ILE A 228
MET A 230
SER A 236
LEU A 237
 ADN  A 301 (-3.1A)
ADN  A 301 (-3.8A)
ADN  A 301 (-3.5A)
ADN  A 301 (-4.5A)
ADN  A 301 (-4.9A)
 1.01A 3nk7B-4x3mA:
25.2		 3nk7B-4x3mA:
30.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb6 ALPHA-D-RIBOSE
1-METHYLPHOSPHONATE
5-PHOSPHATE C-P
LYASE

(Escherichia
coli) 		PF06007
(PhnJ) 		6 PHE D 205
GLY D 206
GLY D  52
ILE D 188
VAL D 125
SER D 186
 None
 1.28A 3nk7B-4xb6D:
undetectable		 3nk7B-4xb6D:
23.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		7 ASN A  17
PHE A 113
GLY A 114
GLY A 119
ILE A 134
SER A 142
LEU A 143
 None
SAH  A 301 (-4.9A)
SAH  A 301 (-2.9A)
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.4A)
SAH  A 301 (-3.8A)
 0.81A 3nk7B-4xboA:
16.1		 3nk7B-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xbo TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Escherichia
coli) 		PF00588
(SpoU_methylase) 		5 GLY A 114
GLU A 116
GLY A 119
ILE A 134
LEU A 143
 SAH  A 301 (-2.9A)
None
SAH  A 301 (-3.2A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.8A)
 0.79A 3nk7B-4xboA:
16.1		 3nk7B-4xboA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xmm NUCLEOPORIN NUP145

(Saccharomyces
cerevisiae) 		PF12110
(Nup96) 		6 LEU B 498
GLU B 194
ILE B 508
LEU B 492
VAL B 494
SER B 495
 None
 1.47A 3nk7B-4xmmB:
undetectable		 3nk7B-4xmmB:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 6 ASN B  14
GLY B 106
ILE B 120
MET B 122
SER B 128
LEU B 129
 None
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
 1.21A 3nk7B-5co4B:
17.5		 3nk7B-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co4 PUTATIVE TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Thermus
thermophilus) 		no annotation 8 ASN B  14
PHE B 100
GLY B 101
GLY B 106
ILE B 120
MET B 122
SER B 128
LEU B 129
 None
MTA  B 401 (-4.9A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.2A)
MTA  B 401 (-3.7A)
MTA  B 401 (-3.4A)
MTA  B 401 ( 3.9A)
MTA  B 401 (-4.3A)
 0.62A 3nk7B-5co4B:
17.5		 3nk7B-5co4B:
25.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ddv 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01128
(IspD) 		6 GLY A  79
GLU A  55
GLY A  80
ILE A   7
LEU A  51
VAL A  77
 None
 1.43A 3nk7B-5ddvA:
2.3		 3nk7B-5ddvA:
24.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		6 ASN A  17
PHE A 114
GLY A 115
GLY A 120
ILE A 135
LEU A 144
 None
 0.66A 3nk7B-5gmbA:
16.6		 3nk7B-5gmbA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmb TRNA
(CYTIDINE/URIDINE-2'
-O-)-METHYLTRANSFERA
SE TRMJ

(Pseudomonas
aeruginosa) 		PF00588
(SpoU_methylase) 		5 GLY A 115
GLU A 117
GLY A 120
ILE A 135
LEU A 144
 None
 0.96A 3nk7B-5gmbA:
16.6		 3nk7B-5gmbA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		6 ASN A 147
GLY A 235
GLY A 240
ILE A 255
SER A 263
LEU A 264
 SO4  A 303 (-3.8A)
SAM  A 304 (-3.2A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
 0.65A 3nk7B-5l0zA:
24.7		 3nk7B-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l0z PROBABLE RNA
METHYLTRANSFERASE,
TRMH FAMILY

(Sinorhizobium
meliloti) 		PF00588
(SpoU_methylase)
PF08032
(SpoU_sub_bind) 		6 GLY A 235
GLU A 237
GLY A 240
ILE A 255
SER A 263
LEU A 264
 SAM  A 304 (-3.2A)
SO4  A 303 ( 4.8A)
SAM  A 304 (-3.4A)
SAM  A 304 (-3.9A)
SAM  A 304 (-3.1A)
SAM  A 304 (-3.8A)
 0.97A 3nk7B-5l0zA:
24.7		 3nk7B-5l0zA:
29.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u38 LECTIN

(Platypodium
elegans) 		PF00139
(Lectin_legB) 		6 LEU A 109
GLY A 106
GLY A 221
ILE A  89
LEU A  34
VAL A  48
 None
MDM  A 304 ( 3.8A)
MDM  A 304 (-3.2A)
None
None
None
 1.44A 3nk7B-5u38A:
undetectable		 3nk7B-5u38A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uja BOVINE MULTIDRUG
RESISTANCE PROTEIN 1
(MRP1),MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 ASN A 725
GLY A 770
ILE A 806
LEU A 778
VAL A 776
 None
 0.98A 3nk7B-5ujaA:
undetectable		 3nk7B-5ujaA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vc1 L-SELECTIN

(Homo sapiens) 		PF00008
(EGF)
PF00059
(Lectin_C) 		5 GLY A  58
GLY A  57
ILE A  53
SER A  68
LEU A  69
 None
None
None
None
PEG  A 207 (-4.4A)
 0.99A 3nk7B-5vc1A:
undetectable		 3nk7B-5vc1A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xns CHROMOSOME PARTITION
PROTEIN SMC

(Pyrococcus
furiosus) 		PF02463
(SMC_N) 		5 PHE A  28
GLY A  27
ILE A1140
SER A1156
LEU A1157
 None
 0.91A 3nk7B-5xnsA:
undetectable		 3nk7B-5xnsA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 5 LEU A 523
GLY A 525
GLY A 584
ILE A 569
LEU A 636
 None
 1.00A 3nk7B-5xv7A:
undetectable		 3nk7B-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b0n ENVELOPE
GLYCOPROTEIN GP140

(Human
immunodeficiency
virus 1) 		no annotation 5 ASN G 363
LEU G 452
GLY G 471
GLY G 472
ILE G 449
 NAG  G1363 (-2.5A)
None
None
None
None
 1.00A 3nk7B-6b0nG:
undetectable		 3nk7B-6b0nG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 LEU X 602
GLY X 604
GLY X 574
ILE X 208
LEU X 595
 None
 0.99A 3nk7B-6elqX:
4.7		 3nk7B-6elqX:
undetectable