SIMILAR PATTERNS OF AMINO ACIDS FOR 3NCQ_C_ACTC120

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLU A 279
LYS A 313
GLU A 316
LYS A 303
GLU A 305
 None
 1.12A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 GLU A 279
LYS A 313
GLU A 316
LYS A 303
GLU A 305
 None
 1.13A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t88 PROLYL ENDOPEPTIDASE

(Pyrococcus
furiosus) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 LYS A 313
GLU A 316
LYS A 303
GLU A 305
GLU A 279
 None
 1.11A 3ncqA-5t88A:
0.0
3ncqB-5t88A:
0.3
3ncqC-5t88A:
0.0		 3ncqA-5t88A:
11.80
3ncqB-5t88A:
11.80
3ncqC-5t88A:
11.80