SIMILAR PATTERNS OF AMINO ACIDS FOR 3NCQ_B_ACTB120

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgf CATALASE

(Homo sapiens) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 350
LYS A 349
ASP A 348
ASP A 157
 HEM  A3000 (-3.7A)
None
None
None
 1.13A 3ncqB-1dgfA:
0.0		 3ncqB-1dgfA:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h7k CATALASE

(Proteus
mirabilis) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 329
LYS A 328
ASP A 327
ASP A 136
 HEM  A 600 (-4.4A)
None
None
None
 1.19A 3ncqB-1h7kA:
0.0		 3ncqB-1h7kA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		4 MET A 233
LYS A 234
ASP A  94
ASP A  92
 None
 1.34A 3ncqB-2c5uA:
0.0		 3ncqB-2c5uA:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 MET A 362
LYS A 407
ASP A 361
ASP A 473
 None
 1.41A 3ncqB-2yfnA:
0.0		 3ncqB-2yfnA:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 361
LYS A 360
ASP A 359
ASP A 168
 HEM  A 537 (-3.9A)
None
None
None
 1.17A 3ncqB-4cabA:
0.0		 3ncqB-4cabA:
10.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e37 CATALASE

(Pseudomonas
aeruginosa) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 MET A 330
LYS A 329
ASP A 328
ASP A 137
 HEM  A 500 (-4.0A)
None
None
None
 1.15A 3ncqB-4e37A:
0.0		 3ncqB-4e37A:
14.67