SIMILAR PATTERNS OF AMINO ACIDS FOR 3NCQ_A_ACTA121

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hu3 EIF4GII

(Homo sapiens) 		PF02854
(MIF4G) 		4 MET A 949
LYS A 946
ASP A 950
ASP A 941
 None
 1.21A 3ncqA-1hu3A:
0.0		 3ncqA-1hu3A:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2or2 1-PHOSPHATIDYLINOSIT
OL PHOSPHODIESTERASE

(Bacillus
thuringiensis) 		PF00388
(PI-PLC-X) 		4 MET A 215
LYS A 212
ASP A 216
ASP A 259
 None
 1.48A 3ncqA-2or2A:
0.2		 3ncqA-2or2A:
16.43