SIMILAR PATTERNS OF AMINO ACIDS FOR 3NBQ_D_URFD400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.24A 3nbqD-1lcyA:
undetectable		 3nbqD-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 GLY A 379
GLN A 273
LEU A 375
LEU A 447
ILE A 451
 None
 1.43A 3nbqD-1mt5A:
undetectable		 3nbqD-1mt5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oi0 HYPOTHETICAL PROTEIN
AF2198

(Archaeoglobus
fulgidus) 		PF14464
(Prok-JAB) 		5 GLY A   9
LEU A  10
LEU A  11
ARG A   8
ILE A   6
 None
 1.49A 3nbqD-1oi0A:
undetectable		 3nbqD-1oi0A:
23.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 THR A 315
GLY A 174
MET A 171
LEU A 313
ILE A 113
 None
 1.45A 3nbqD-2bbvA:
undetectable		 3nbqD-2bbvA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3r LECTIN ALPHA CHAIN

(Cratylia
argentea) 		PF00139
(Lectin_legB) 		5 GLY A 226
LEU A 229
LEU A 228
ARG A 227
ILE A  32
 None
 1.45A 3nbqD-2d3rA:
undetectable		 3nbqD-2d3rA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 GLY A  70
ARG A 103
LEU A  79
LEU A  76
ILE A  68
 None
 1.28A 3nbqD-2d4pA:
undetectable		 3nbqD-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 THR A1095
GLN A1166
ARG A1168
MET A1197
ARG A1223
 None
 1.44A 3nbqD-2oxfA:
13.7		 3nbqD-2oxfA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzd SERINE PROTEASE
HTRA2

(Homo sapiens) 		PF13180
(PDZ_2) 		5 GLY A 406
ARG A 443
LEU A 407
LEU A 450
ILE A 441
 None
 1.36A 3nbqD-2pzdA:
undetectable		 3nbqD-2pzdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vo1 CTP SYNTHASE 1

(Homo sapiens) 		PF06418
(CTP_synth_N) 		5 GLY A 208
GLN A 167
LEU A 204
ARG A 164
ILE A 160
 None
 1.37A 3nbqD-2vo1A:
3.2		 3nbqD-2vo1A:
24.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 197
GLN A 274
LEU A 255
LEU A 196
ILE A 165
 None
 1.34A 3nbqD-2xt6A:
3.5		 3nbqD-2xt6A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		6 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
ARG A 311
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
None
 0.37A 3nbqD-3bjeA:
23.5		 3nbqD-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edu SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		5 THR A1739
GLY A1743
GLN A1744
LEU A1702
ILE A1706
 None
 1.32A 3nbqD-3eduA:
undetectable		 3nbqD-3eduA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		8 THR A 141
GLY A 143
GLN A 217
ARG A 219
MET A 249
LEU A 272
LEU A 273
ARG A 275
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
None
 0.28A 3nbqD-3eufA:
48.5		 3nbqD-3eufA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 141
GLY A 143
LEU A 272
LEU A 273
ILE A 281
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
BAU  A 400 (-4.7A)
 0.84A 3nbqD-3eufA:
48.5		 3nbqD-3eufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 THR A  35
GLY A  32
LEU A  27
LEU A  31
ILE A 452
 None
 1.44A 3nbqD-3gwfA:
undetectable		 3nbqD-3gwfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.02A 3nbqD-3h1lC:
undetectable		 3nbqD-3h1lC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		5 THR A 138
GLY A 143
GLN A 337
LEU A 142
LEU A 209
 None
 1.46A 3nbqD-3igfA:
2.8		 3nbqD-3igfA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		9 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ARG A 274
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
None
 0.23A 3nbqD-3kvyA:
46.5		 3nbqD-3kvyA:
75.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		8 THR A 147
GLY A 149
GLN A 223
ARG A 225
MET A 255
LEU A 278
LEU A 279
ARG A 281
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
None
 0.37A 3nbqD-3p0fA:
44.1		 3nbqD-3p0fA:
62.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 149
LEU A 278
LEU A 279
ILE A 287
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
BAU  A 400 (-4.6A)
 0.73A 3nbqD-3p0fA:
44.1		 3nbqD-3p0fA:
62.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.09A 3nbqD-3sqwA:
undetectable		 3nbqD-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbj ACTIBIND

(Aspergillus
niger) 		PF00445
(Ribonuclease_T2) 		5 THR A  99
GLN A 105
LEU A 111
LEU A 110
ARG A 107
 None
None
None
PO4  A 305 (-4.2A)
None
 1.49A 3nbqD-3tbjA:
undetectable		 3nbqD-3tbjA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4k ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF13234
(rRNA_proc-arch) 		5 THR A 935
GLY A 917
LEU A 916
LEU A 904
ILE A1013
 None
 1.44A 3nbqD-4a4kA:
undetectable		 3nbqD-4a4kA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsx TIR
DOMAIN-CONTAINING
ADAPTER MOLECULE 1

(Homo sapiens) 		no annotation 5 GLY A  39
GLN A  38
ARG A 143
LEU A  99
LEU A 102
 None
 1.42A 3nbqD-4bsxA:
undetectable		 3nbqD-4bsxA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 GLY A 614
MET A 568
LEU A 610
ARG A 617
ILE A 260
 None
None
None
ANP  A1662 (-3.0A)
None
 1.41A 3nbqD-4c30A:
undetectable		 3nbqD-4c30A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jxy TRANS-HEXAPRENYLTRAN
STRANSFERASE

(Pseudoalteromonas
atlantica) 		PF00348
(polyprenyl_synt) 		5 GLY A 183
ARG A 130
LEU A 181
LEU A 180
ILE A 134
 None
GUA  A 402 (-3.7A)
None
GUA  A 402 (-4.8A)
GUA  A 402 (-4.0A)
 1.40A 3nbqD-4jxyA:
undetectable		 3nbqD-4jxyA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.24A 3nbqD-4k6jA:
undetectable		 3nbqD-4k6jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp4 GLUTATHIONE
S-TRANSFERASE

(Acinetobacter
baumannii) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 THR A  22
GLY A  26
LEU A  77
LEU A  80
ILE A  76
 None
 1.30A 3nbqD-4mp4A:
undetectable		 3nbqD-4mp4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 THR A 160
GLY A 270
LEU A 271
LEU A 272
ILE A 268
 None
MG  A 304 (-3.9A)
None
None
None
 1.46A 3nbqD-4q2eA:
undetectable		 3nbqD-4q2eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 GLN A 163
ARG A 165
MET A 194
ARG A 220
ILE A 225
 None
None
GOL  A 303 (-3.5A)
None
None
 1.16A 3nbqD-4r2wA:
25.7		 3nbqD-4r2wA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		6 THR A  91
GLY A  93
GLN A 163
ARG A 165
MET A 194
ARG A 220
 SO4  A 302 ( 3.0A)
None
None
None
GOL  A 303 (-3.5A)
None
 0.45A 3nbqD-4r2wA:
25.7		 3nbqD-4r2wA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		5 GLY A  94
GLN A 164
ARG A 166
MET A 195
ARG A 221
 None
None
None
GOL  A 301 (-4.0A)
None
 0.78A 3nbqD-4r31A:
25.6		 3nbqD-4r31A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLN A 164
ARG A 166
MET A 195
ARG A 221
 None
None
None
GOL  A 301 (-4.0A)
None
 1.38A 3nbqD-4r31A:
25.6		 3nbqD-4r31A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 THR A 678
GLY A 428
LEU A 424
LEU A 427
ILE A 418
 None
 1.49A 3nbqD-4umvA:
2.8		 3nbqD-4umvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 249
MET A 242
LEU A 291
LEU A 290
ILE A 275
 None
 1.16A 3nbqD-5f56A:
3.5		 3nbqD-5f56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fqe BETA-N-ACETYLGALACTO
SAMINIDASE

(Clostridium
perfringens) 		PF13320
(DUF4091) 		5 GLY A 279
GLN A 176
LEU A 272
ARG A 219
ILE A 271
 BR  A1634 (-4.4A)
None
None
BR  A1634 ( 4.8A)
None
 1.20A 3nbqD-5fqeA:
undetectable		 3nbqD-5fqeA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		5 THR A 223
GLY A 398
MET A 423
LEU A 399
ILE A 394
 None
None
None
6TO  A 800 (-4.0A)
None
 1.48A 3nbqD-5kjuA:
undetectable		 3nbqD-5kjuA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kjv HYDROXYCINNAMOYL
TRANSFERASE

(Plectranthus
scutellarioides) 		PF02458
(Transferase) 		5 THR A 217
GLY A 392
MET A 417
LEU A 393
ILE A 388
 None
 1.46A 3nbqD-5kjvA:
undetectable		 3nbqD-5kjvA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		6 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
ARG A 222
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
None
 0.50A 3nbqD-5lhvA:
26.1		 3nbqD-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.24A 3nbqD-5mdnA:
undetectable		 3nbqD-5mdnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u03 CTP SYNTHASE 1

(Homo sapiens) 		PF00117
(GATase)
PF06418
(CTP_synth_N) 		5 GLY A 208
GLN A 167
LEU A 207
ARG A 164
ILE A 160
 None
 1.32A 3nbqD-5u03A:
3.3		 3nbqD-5u03A:
19.46