SIMILAR PATTERNS OF AMINO ACIDS FOR 3NBQ_C_URFC400_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bf5 SIGNAL TRANSDUCER
AND ACTIVATOR OF
TRANSCRIPTION
1-ALPHA/BETA

(Homo sapiens) 		PF00017
(SH2)
PF01017
(STAT_alpha)
PF02864
(STAT_bind) 		4 GLY A 523
LEU A 526
LEU A 527
ILE A 537
 None
 0.76A 3nbqC-1bf5A:
0.1		 3nbqC-1bf5A:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		4 GLY A 138
LEU A 181
LEU A 165
ILE A 161
 None
 0.86A 3nbqC-1e6zA:
0.0		 3nbqC-1e6zA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g31 GP31

(Escherichia
virus T4) 		PF00166
(Cpn10) 		4 THR A  69
GLN A  24
LEU A  71
ILE A  76
 None
 0.74A 3nbqC-1g31A:
undetectable		 3nbqC-1g31A:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ihm CAPSID PROTEIN

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		4 THR A1119
GLY A1121
LEU A1190
ILE A1070
 None
 0.93A 3nbqC-1ihmA:
0.0		 3nbqC-1ihmA:
20.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1keh PRECURSOR OF
CEPHALOSPORIN
ACYLASE

(Brevundimonas
diminuta) 		PF01804
(Penicil_amidase) 		4 THR A 218
GLY A 216
GLN A 189
ILE A 326
 None
 0.89A 3nbqC-1kehA:
0.0		 3nbqC-1kehA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l2q MONOMETHYLAMINE
METHYLTRANSFERASE

(Methanosarcina
barkeri) 		PF05369
(MtmB) 		4 GLY A  74
LEU A  71
LEU A  70
ILE A  91
 None
 0.85A 3nbqC-1l2qA:
0.0		 3nbqC-1l2qA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		4 GLY A 273
ARG A 310
LEU A 317
ILE A 308
 None
 0.86A 3nbqC-1lcyA:
0.0		 3nbqC-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1now BETA-HEXOSAMINIDASE
BETA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 GLY A 299
LEU A 305
LEU A 306
ILE A 322
 None
 0.83A 3nbqC-1nowA:
1.2		 3nbqC-1nowA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ptx SCORPION TOXIN II

(Androctonus
australis) 		PF00537
(Toxin_3) 		4 GLY A  31
LEU A  29
LEU A  51
ILE A   6
 None
 0.84A 3nbqC-1ptxA:
0.0		 3nbqC-1ptxA:
11.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgu PROTEIN (NITROGENASE
MOLYBDENUM IRON
PROTEIN)

(Klebsiella
pneumoniae) 		PF00148
(Oxidored_nitro) 		4 THR A 148
GLY A 146
LEU A 257
ILE A 205
 None
 0.87A 3nbqC-1qguA:
3.3		 3nbqC-1qguA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1seg AAH2: LQH-ALPHA-IT
(FACE) CHIMERIC
TOXIN

(Androctonus
australis) 		PF00537
(Toxin_3) 		4 GLY A  31
LEU A  29
LEU A  51
ILE A   6
 None
 0.87A 3nbqC-1segA:
undetectable		 3nbqC-1segA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 GLY A 597
LEU A 459
LEU A 456
ILE A 546
 None
 0.74A 3nbqC-1taqA:
undetectable		 3nbqC-1taqA:
17.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v5c CHITOSANASE

(Bacillus sp.
(in: Bacteria)) 		PF01270
(Glyco_hydro_8) 		4 THR A 154
MET A 164
LEU A  98
LEU A  95
 None
 0.92A 3nbqC-1v5cA:
undetectable		 3nbqC-1v5cA:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xrs D-LYSINE
5,6-AMINOMUTASE
ALPHA SUBUNIT

(Acetoanaerobium
sticklandii) 		PF09043
(Lys-AminoMut_A) 		4 THR A 312
LEU A 464
LEU A 465
ILE A 468
 None
 0.91A 3nbqC-1xrsA:
undetectable		 3nbqC-1xrsA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xx4 3,2-TRANS-ENOYL-COA
ISOMERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF00378
(ECH_1) 		4 THR A 197
GLY A 162
LEU A 209
ILE A 184
 None
 0.83A 3nbqC-1xx4A:
undetectable		 3nbqC-1xx4A:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym5 HYPOTHETICAL 32.6
KDA PROTEIN IN
DAP2-SLT2 INTERGENIC
REGION

(Saccharomyces
cerevisiae) 		PF02567
(PhzC-PhzF) 		4 THR A 172
GLY A 199
LEU A 166
ILE A 150
 None
 0.82A 3nbqC-1ym5A:
undetectable		 3nbqC-1ym5A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zo1 TRANSLATION
INITIATION FACTOR 1

(Escherichia
coli) 		PF01176
(eIF-1a) 		4 THR W   9
GLY W  11
LEU W  26
ILE W  32
 None
 0.91A 3nbqC-1zo1W:
undetectable		 3nbqC-1zo1W:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaf ARGININE DEIMINASE

(Pseudomonas
aeruginosa) 		PF02274
(Amidinotransf) 		4 GLY A 239
MET A 229
LEU A 270
ILE A 301
 None
 0.81A 3nbqC-2aafA:
undetectable		 3nbqC-2aafA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2adv GLUTARYL 7-
AMINOCEPHALOSPORANIC
ACID ACYLASE

(Pseudomonas sp.
SY-77-1) 		PF01804
(Penicil_amidase) 		4 THR C  49
GLY C  47
GLN B  20
ILE C 157
 None
 0.93A 3nbqC-2advC:
undetectable		 3nbqC-2advC:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		4 GLY A 261
LEU A 262
LEU A  87
ILE A  83
 None
 0.94A 3nbqC-2b9bA:
undetectable		 3nbqC-2b9bA:
23.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4n DU

(Mason-Pfizer
monkey virus) 		PF00692
(dUTPase) 		4 THR A 154
GLY A 156
LEU A 206
ILE A 110
 None
 0.80A 3nbqC-2d4nA:
undetectable		 3nbqC-2d4nA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2day RING FINGER PROTEIN
25

(Homo sapiens) 		PF05773
(RWD) 		4 GLY A 118
LEU A  63
LEU A  46
ILE A  44
 None
 0.86A 3nbqC-2dayA:
undetectable		 3nbqC-2dayA:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db3 ATP-DEPENDENT RNA
HELICASE VASA

(Drosophila
melanogaster) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 377
LEU A 379
LEU A 380
ILE A 416
 U  E   6 ( 3.2A)
None
None
None
 0.89A 3nbqC-2db3A:
undetectable		 3nbqC-2db3A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecf DIPEPTIDYL PEPTIDASE
IV

(Stenotrophomonas
maltophilia) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		4 GLY A 589
GLN A 586
LEU A 593
ILE A 604
 None
 0.78A 3nbqC-2ecfA:
undetectable		 3nbqC-2ecfA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f6g HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
baylyi) 		PF03466
(LysR_substrate) 		4 GLY A 232
LEU A 231
LEU A 252
ILE A 250
 None
 0.87A 3nbqC-2f6gA:
undetectable		 3nbqC-2f6gA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk1 BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN A
BETA-HEXOSAMINIDASE
SUBUNIT BETA CHAIN B

(Homo sapiens) 		no annotation 4 GLY M 299
LEU M 305
LEU M 306
ILE N 322
 None
 0.78A 3nbqC-2gk1M:
undetectable		 3nbqC-2gk1M:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hku A PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Rhodococcus
jostii) 		PF00440
(TetR_N)
PF16914
(TetR_C_12) 		4 GLY A  99
LEU A 101
LEU A 102
ILE A 170
 None
 0.83A 3nbqC-2hkuA:
undetectable		 3nbqC-2hkuA:
19.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mpv MAJOR FIMBRIAL
SUBUNIT OF
AGGREGATIVE
ADHERENCE FIMBRIA II
AAFA

(Escherichia
coli) 		no annotation 4 GLY A  58
GLN A  64
LEU A 130
ILE A  41
 None
 0.70A 3nbqC-2mpvA:
undetectable		 3nbqC-2mpvA:
18.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2opt ACTII PROTEIN

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 GLY A 159
LEU A 162
LEU A 163
ILE A 233
 None
 0.86A 3nbqC-2optA:
undetectable		 3nbqC-2optA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1z PHOSPHORIBOSYLTRANSF
ERASE

(Corynebacterium
diphtheriae) 		PF00156
(Pribosyltran) 		4 GLY A  49
LEU A  51
LEU A  52
ILE A 168
 None
 0.82A 3nbqC-2p1zA:
undetectable		 3nbqC-2p1zA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pzd SERINE PROTEASE
HTRA2

(Homo sapiens) 		PF13180
(PDZ_2) 		4 GLY A 406
ARG A 443
LEU A 450
ILE A 441
 None
 0.87A 3nbqC-2pzdA:
undetectable		 3nbqC-2pzdA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3abi PUTATIVE
UNCHARACTERIZED
PROTEIN PH1688

(Pyrococcus
horikoshii) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 GLY A 275
LEU A 136
LEU A 134
ILE A 130
 None
 0.78A 3nbqC-3abiA:
undetectable		 3nbqC-3abiA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aq1 THERMOSOME SUBUNIT

(Methanococcoides
burtonii) 		PF00118
(Cpn60_TCP1) 		4 GLY B 467
GLN B 458
LEU B 468
ILE B 451
 None
 0.82A 3nbqC-3aq1B:
undetectable		 3nbqC-3aq1B:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1r RIBOKINASE, PUTATIVE

(Burkholderia
thailandensis) 		PF00294
(PfkB) 		4 GLY A 257
LEU A 259
LEU A 260
ILE A 164
 None
 0.77A 3nbqC-3b1rA:
undetectable		 3nbqC-3b1rA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		5 THR A 140
GLY A 142
GLN A 246
ARG A 248
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 3.9A)
 0.24A 3nbqC-3bjeA:
23.4		 3nbqC-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cf0 TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Mus musculus) 		PF00004
(AAA)
PF09336
(Vps4_C) 		4 THR A 623
GLY A 621
LEU A 639
ILE A 633
 None
 0.55A 3nbqC-3cf0A:
undetectable		 3nbqC-3cf0A:
21.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		7 THR A 141
GLY A 143
GLN A 217
ARG A 219
MET A 249
LEU A 272
LEU A 273
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
BAU  A 400 (-3.8A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
 0.26A 3nbqC-3eufA:
48.5		 3nbqC-3eufA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 141
GLY A 143
LEU A 272
LEU A 273
ILE A 281
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
BAU  A 400 (-4.7A)
 0.75A 3nbqC-3eufA:
48.5		 3nbqC-3eufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gfv UNCHARACTERIZED ABC
TRANSPORTER
SOLUTE-BINDING
PROTEIN YCLQ

(Bacillus
subtilis) 		PF01497
(Peripla_BP_2) 		4 THR A 226
LEU A 175
LEU A 231
ILE A 177
 None
 0.93A 3nbqC-3gfvA:
undetectable		 3nbqC-3gfvA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 GLY A1155
LEU A1157
LEU A1158
ILE A1000
 None
 0.89A 3nbqC-3hngA:
undetectable		 3nbqC-3hngA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3icu E3 UBIQUITIN-PROTEIN
LIGASE RNF128

(Homo sapiens) 		PF02225
(PA) 		4 GLY A  69
MET A 158
LEU A  47
ILE A 193
 None
 0.80A 3nbqC-3icuA:
undetectable		 3nbqC-3icuA:
19.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3id3 REGULATOR OF SIGMA E
PROTEASE

(Escherichia
coli) 		PF00595
(PDZ) 		4 GLY A 239
ARG A 278
LEU A 285
ILE A 276
 None
 0.83A 3nbqC-3id3A:
undetectable		 3nbqC-3id3A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iu6 PROTEIN POLYBROMO-1

(Homo sapiens) 		PF00439
(Bromodomain) 		4 GLY A 851
LEU A 749
LEU A 745
ILE A 746
 None
 0.86A 3nbqC-3iu6A:
undetectable		 3nbqC-3iu6A:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jac PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.93A 3nbqC-3jacA:
undetectable		 3nbqC-3jacA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k1n HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM

(Acinetobacter
sp. ADP1) 		PF00126
(HTH_1)
PF03466
(LysR_substrate) 		4 GLY A 232
LEU A 231
LEU A 252
ILE A 250
 None
 0.84A 3nbqC-3k1nA:
undetectable		 3nbqC-3k1nA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		8 THR A 140
GLY A 142
GLN A 216
ARG A 218
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
URA  A 312 ( 3.7A)
None
None
None
 0.16A 3nbqC-3kvyA:
46.5		 3nbqC-3kvyA:
75.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		7 THR A 147
GLY A 149
GLN A 223
ARG A 225
MET A 255
LEU A 278
LEU A 279
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
BAU  A 400 (-3.9A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
 0.35A 3nbqC-3p0fA:
43.9		 3nbqC-3p0fA:
62.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 149
LEU A 278
LEU A 279
ILE A 287
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
BAU  A 400 (-4.6A)
 0.64A 3nbqC-3p0fA:
43.9		 3nbqC-3p0fA:
62.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pf2 CELL WALL SURFACE
ANCHOR FAMILY
PROTEIN

(Streptococcus
agalactiae) 		PF16569
(GramPos_pilinBB)
PF16570
(GramPos_pilinD3) 		4 THR A 223
GLY A 381
LEU A 452
ILE A 449
 None
 0.85A 3nbqC-3pf2A:
undetectable		 3nbqC-3pf2A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pie 5'->3'
EXORIBONUCLEASE
(XRN1)

(Kluyveromyces
lactis) 		PF03159
(XRN_N) 		4 GLN A  16
LEU A 744
LEU A 746
ILE A 771
 None
 0.73A 3nbqC-3pieA:
undetectable		 3nbqC-3pieA:
14.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8x METHIONYL-TRNA
FORMYLTRANSFERASE

(Yersinia pestis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLY A  21
LEU A  23
LEU A  24
ILE A  30
 None
 0.89A 3nbqC-3r8xA:
undetectable		 3nbqC-3r8xA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrl SUCCINYL-COA:3-KETOA
CID-COENZYME A
TRANSFERASE SUBUNIT
A

(Helicobacter
pylori) 		PF01144
(CoA_trans) 		4 GLY A  62
LEU A  64
LEU A  65
ILE A  70
 None
 0.78A 3nbqC-3rrlA:
undetectable		 3nbqC-3rrlA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.90A 3nbqC-3sqwA:
undetectable		 3nbqC-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tlm SARCOPLASMIC/ENDOPLA
SMIC RETICULUM
CALCIUM ATPASE 1

(Bos taurus) 		PF00122
(E1-E2_ATPase)
PF00689
(Cation_ATPase_C)
PF00690
(Cation_ATPase_N)
PF08282
(Hydrolase_3)
PF13246
(Cation_ATPase) 		4 GLY A  17
GLN A  28
LEU A  13
ILE A 222
 None
 0.85A 3nbqC-3tlmA:
undetectable		 3nbqC-3tlmA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 GLY A  90
GLN A  47
LEU A  92
ILE A  63
 None
 0.82A 3nbqC-3v48A:
undetectable		 3nbqC-3v48A:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsk PENICILLIN-BINDING
PROTEIN 3

(Staphylococcus
aureus) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 GLN A 170
LEU A 182
LEU A 179
ILE A 120
 None
 0.83A 3nbqC-3vskA:
undetectable		 3nbqC-3vskA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ab5 TRANSCRIPTIONAL
REGULATOR, LYSR
FAMILY

(Neisseria
meningitidis) 		PF03466
(LysR_substrate) 		4 GLY A 138
LEU A 140
LEU A 141
ILE A 159
 None
 0.77A 3nbqC-4ab5A:
undetectable		 3nbqC-4ab5A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3k BETA-GLUCOSIDASE

(Streptococcus
pyogenes) 		PF00232
(Glyco_hydro_1) 		4 THR A 221
GLY A 295
LEU A 223
LEU A 296
 None
 0.90A 3nbqC-4b3kA:
undetectable		 3nbqC-4b3kA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c30 DNA HELICASE II

(Deinococcus
radiodurans) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		4 THR A  39
GLY A  35
GLN A 258
ARG A 617
 MG  A1663 ( 2.8A)
ANP  A1662 (-3.1A)
ANP  A1662 (-3.2A)
ANP  A1662 (-3.0A)
 0.90A 3nbqC-4c30A:
undetectable		 3nbqC-4c30A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		4 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.89A 3nbqC-4db4A:
undetectable		 3nbqC-4db4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxd DNA POLYMERASE ALPHA
CATALYTIC SUBUNIT A

(Saccharomyces
cerevisiae) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		4 THR A1004
MET A 988
LEU A 861
ILE A1034
 None
 0.86A 3nbqC-4fxdA:
undetectable		 3nbqC-4fxdA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4go4 PUTATIVE
GAMMA-HYDROXYMUCONIC
SEMIALDEHYDE
DEHYDROGENASE

(Pseudomonas sp.
WBC-3) 		PF00171
(Aldedh) 		4 GLY A 448
MET A 459
LEU A 409
ILE A 282
 None
None
NAD  A 601 (-4.3A)
None
 0.80A 3nbqC-4go4A:
undetectable		 3nbqC-4go4A:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvl TRKA DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF02080
(TrkA_C)
PF02254
(TrkA_N) 		4 GLY A 474
LEU A 476
LEU A 477
ILE A 224
 None
 0.84A 3nbqC-4gvlA:
1.5		 3nbqC-4gvlA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf8 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 1

(Rattus
norvegicus) 		PF10613
(Lig_chan-Glu_bd) 		4 GLY A 111
LEU A 113
LEU A 114
ILE A 135
 None
 0.93A 3nbqC-4nf8A:
undetectable		 3nbqC-4nf8A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o6r ALDEHYDE
DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00171
(Aldedh) 		4 GLY A 449
MET A 460
LEU A 410
ILE A 282
 None
None
None
NO3  A 502 (-4.8A)
 0.60A 3nbqC-4o6rA:
undetectable		 3nbqC-4o6rA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q0g PROBABLE
ACETYL-/PROPIONYL-CO
A CARBOXYLASE (BETA
SUBUNIT) ACCD1

(Mycobacterium
tuberculosis) 		PF01039
(Carboxyl_trans) 		4 THR A 323
GLY A 334
LEU A 364
ILE A 354
 None
 0.88A 3nbqC-4q0gA:
undetectable		 3nbqC-4q0gA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qts CRISPR TYPE
III-ASSOCIATED RAMP
PROTEIN CSM4

(Methanocaldococcus
jannaschii) 		PF03787
(RAMPs) 		4 THR A 317
GLY A 276
MET A 273
ILE A  27
 None
 0.85A 3nbqC-4qtsA:
undetectable		 3nbqC-4qtsA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		5 THR A  91
GLY A  93
GLN A 163
ARG A 165
MET A 194
 SO4  A 302 ( 3.0A)
None
None
None
GOL  A 303 (-3.5A)
 0.28A 3nbqC-4r2wA:
25.5		 3nbqC-4r2wA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rax PIEZO-TYPE
MECHANOSENSITIVE ION
CHANNEL COMPONENT 1

(Mus musculus) 		PF12166
(Piezo_RRas_bdg) 		4 GLY A2360
ARG A2301
LEU A2357
LEU A2405
 None
 0.92A 3nbqC-4raxA:
undetectable		 3nbqC-4raxA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 GLY A1877
LEU A1879
LEU A1880
ILE A1897
 None
 0.80A 3nbqC-4rh7A:
undetectable		 3nbqC-4rh7A:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzz PEPTIDASE M24

(Ruegeria
lacuscaerulensis) 		PF00557
(Peptidase_M24) 		4 THR A  64
GLY A  74
LEU A 106
LEU A 105
 None
 0.81A 3nbqC-4rzzA:
undetectable		 3nbqC-4rzzA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 0.91A 3nbqC-4tz0A:
undetectable		 3nbqC-4tz0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xtl SODIUM PUMPING
RHODOPSIN

(Dokdonia
eikasta) 		PF01036
(Bac_rhodopsin) 		4 GLY A 259
LEU A 261
LEU A 262
ILE A 207
 LYR  A 255 ( 3.6A)
None
None
None
 0.88A 3nbqC-4xtlA:
undetectable		 3nbqC-4xtlA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ywo MERCURIC REDUCTASE

(Metallosphaera
sedula) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 THR A 130
GLY A 291
LEU A 294
ILE A 274
 FAD  A 501 (-3.8A)
FAD  A 501 (-3.3A)
GOL  A 506 (-4.2A)
None
 0.92A 3nbqC-4ywoA:
undetectable		 3nbqC-4ywoA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwn MONOGLYCERIDE LIPASE

(Saccharomyces
cerevisiae) 		PF12146
(Hydrolase_4) 		4 GLY A 200
LEU A 184
LEU A 186
ILE A 189
 None
 0.91A 3nbqC-4zwnA:
2.7		 3nbqC-4zwnA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a6b N-ACETYL-BETA-D-GLUC
OSAMINIDASE

(Streptococcus
pneumoniae) 		PF00728
(Glyco_hydro_20) 		4 GLY D 563
LEU D 565
LEU D 566
ILE D 535
 None
 0.89A 3nbqC-5a6bD:
undetectable		 3nbqC-5a6bD:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 GLN A   7
LEU A 167
LEU A 164
ILE A  13
 None
 0.88A 3nbqC-5amqA:
undetectable		 3nbqC-5amqA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c1b TRANSITIONAL
ENDOPLASMIC
RETICULUM ATPASE

(Homo sapiens) 		PF00004
(AAA)
PF02359
(CDC48_N)
PF02933
(CDC48_2)
PF09336
(Vps4_C) 		4 THR A 623
GLY A 621
LEU A 639
ILE A 633
 None
 0.59A 3nbqC-5c1bA:
undetectable		 3nbqC-5c1bA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03170
(BcsB)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 GLY B 700
LEU B 698
LEU B 697
ILE A  45
 None
 0.88A 3nbqC-5ej1B:
undetectable		 3nbqC-5ej1B:
18.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 4 THR A  24
LEU A 339
LEU A 341
ILE A 324
 GOL  A1348 (-4.5A)
None
None
None
 0.87A 3nbqC-5fzpA:
undetectable		 3nbqC-5fzpA:
22.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ibz UNCHARACTERIZED
PROTEIN

(uncultured
organism) 		PF04199
(Cyclase) 		4 GLY A 287
LEU A 289
LEU A 290
ILE A 297
 None
 0.79A 3nbqC-5ibzA:
undetectable		 3nbqC-5ibzA:
22.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5imu TAT (TWIN-ARGININE
TRANSLOCATION)
PATHWAY SIGNAL
SEQUENCE CONTAINING
PROTEIN

(Mycobacterium
tuberculosis) 		no annotation 4 GLY A 348
LEU A 346
LEU A 345
ILE A 324
 None
 0.88A 3nbqC-5imuA:
undetectable		 3nbqC-5imuA:
26.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLY A  95
GLN A 165
ARG A 167
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 3.7A)
 0.28A 3nbqC-5lhvA:
25.9		 3nbqC-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tul TETRACYCLINE
DESTRUCTASE TET(55)

(uncultured
bacterium) 		PF01494
(FAD_binding_3) 		4 THR A 293
GLY A 157
ARG A  40
LEU A 158
 None
PO4  A 401 (-3.5A)
None
None
 0.89A 3nbqC-5tulA:
undetectable		 3nbqC-5tulA:
22.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w7z DNA POLYMERASE III
SUBUNIT BETA

(Rickettsia
conorii) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		4 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.74A 3nbqC-5w7zA:
undetectable		 3nbqC-5w7zA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wy4 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		no annotation 4 GLY A 252
MET A 259
LEU A 248
ILE A 288
 None
 0.85A 3nbqC-5wy4A:
undetectable		 3nbqC-5wy4A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x59 S PROTEIN

(Middle East
respiratory
syndrome-related
coronavirus) 		PF01601
(Corona_S2)
PF09408
(Spike_rec_bind) 		4 THR A 986
GLY A 982
LEU A 980
ILE A1123
 None
 0.80A 3nbqC-5x59A:
undetectable		 3nbqC-5x59A:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x62 CARNOSINE
N-METHYLTRANSFERASE

(Saccharomyces
cerevisiae) 		PF07942
(N2227) 		4 GLY A 150
LEU A 152
LEU A 153
ILE A 144
 None
 0.89A 3nbqC-5x62A:
undetectable		 3nbqC-5x62A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x6o SERINE/THREONINE-PRO
TEIN KINASE MEC1

(Saccharomyces
cerevisiae) 		no annotation 4 GLY C1096
LEU C1098
LEU C1099
ILE C1120
 None
 0.88A 3nbqC-5x6oC:
undetectable		 3nbqC-5x6oC:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yp3 DIPEPTIDYL
AMINOPEPTIDASE 4

(Pseudoxanthomonas
mexicana) 		no annotation 4 GLY A 592
GLN A 589
LEU A 596
ILE A 607
 None
 0.83A 3nbqC-5yp3A:
2.1		 3nbqC-5yp3A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5znn SORTILIN

(Mus musculus) 		no annotation 4 THR A 428
GLY A 410
LEU A 634
ILE A 716
 None
 0.82A 3nbqC-5znnA:
undetectable		 3nbqC-5znnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b4e NUCLEOPORIN GLE1

(Saccharomyces
cerevisiae) 		no annotation 4 GLN B 295
LEU B 313
LEU B 310
ILE B 289
 None
 0.91A 3nbqC-6b4eB:
undetectable		 3nbqC-6b4eB:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 THR A 826
GLN A 774
LEU A 824
ILE A 811
 None
 0.75A 3nbqC-6bhuA:
undetectable		 3nbqC-6bhuA:
0.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cc4 SOLUBLE CYTOCHROME
B562, LIPID II
FLIPPASE MURJ
CHIMERA

(Escherichia
coli) 		no annotation 4 GLY A 457
LEU A 459
LEU A 460
ILE A 327
 None
 0.85A 3nbqC-6cc4A:
undetectable		 3nbqC-6cc4A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6crj NORWALK VIRUS, MNV-1
CAPSID PROTEIN
CHIMERA

(Norwalk virus) 		no annotation 4 THR B 119
GLY B 121
LEU B 190
ILE B  70
 None
 0.82A 3nbqC-6crjB:
undetectable		 3nbqC-6crjB:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d46 BETA SLIDING CLAMP

(Rickettsia
typhi) 		no annotation 4 THR A   8
LEU A  87
LEU A  89
ILE A  99
 None
 0.80A 3nbqC-6d46A:
undetectable		 3nbqC-6d46A:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f71 GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 4 ARG A  20
LEU A 121
LEU A 122
ILE A 171
 None
 0.92A 3nbqC-6f71A:
undetectable		 3nbqC-6f71A:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fae IQ MOTIF AND SEC7
DOMAIN-CONTAINING
PROTEIN 2

(Homo sapiens) 		no annotation 4 GLY A 457
LEU A 456
LEU A 505
ILE A 493
 None
 0.92A 3nbqC-6faeA:
undetectable		 3nbqC-6faeA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 GLY A 283
LEU A 335
LEU A 368
ILE A 364
 None
 0.78A 3nbqC-6fv5A:
undetectable		 3nbqC-6fv5A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 4 GLY A 376
LEU A 378
LEU A 379
ILE A 364
 None
 0.86A 3nbqC-6fv5A:
undetectable		 3nbqC-6fv5A:
13.38