SIMILAR PATTERNS OF AMINO ACIDS FOR 3NBQ_A_URFA400

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d5y ROB TRANSCRIPTION
FACTOR

(Escherichia
coli) 		PF06445
(GyrI-like)
PF12833
(HTH_18) 		5 THR A 136
GLY A 221
GLU A 134
LEU A 219
ILE A 261
 None
 1.04A 3nbqA-1d5yA:
undetectable		 3nbqA-1d5yA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ezv UBIQUINOL-CYTOCHROME
C REDUCTASE COMPLEX
CORE PROTEIN 2

(Saccharomyces
cerevisiae) 		PF00675
(Peptidase_M16) 		5 THR B  77
GLY B  75
GLU B  72
LEU B  94
ILE B  28
 None
 0.98A 3nbqA-1ezvB:
undetectable		 3nbqA-1ezvB:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fs2 SKP2

(Homo sapiens) 		PF12937
(F-box-like) 		5 GLY A 369
GLU A 367
LEU A 377
LEU A 398
ILE A 400
 None
 1.06A 3nbqA-1fs2A:
undetectable		 3nbqA-1fs2A:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hpl LIPASE

(Equus caballus) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 GLY A   9
ARG A 164
GLU A   2
LEU A   8
ILE A 123
 None
 1.35A 3nbqA-1hplA:
3.2		 3nbqA-1hplA:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		5 THR A 287
GLN A  32
GLU A 284
LEU A  48
ILE A  57
 None
 1.37A 3nbqA-1hzoA:
undetectable		 3nbqA-1hzoA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko7 HPR
KINASE/PHOSPHATASE

(Staphylococcus
xylosus) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		5 THR A 254
GLU A 255
LEU A 187
LEU A 224
ILE A 179
 None
 1.35A 3nbqA-1ko7A:
undetectable		 3nbqA-1ko7A:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lcy HTRA2 SERINE
PROTEASE

(Homo sapiens) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 273
ARG A 310
LEU A 274
LEU A 317
ILE A 308
 None
 1.19A 3nbqA-1lcyA:
undetectable		 3nbqA-1lcyA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lpb LIPASE

(Homo sapiens) 		PF00151
(Lipase)
PF01477
(PLAT) 		5 GLY B   9
ARG B 164
GLU B   2
LEU B   8
ILE B 123
 None
 1.28A 3nbqA-1lpbB:
3.6		 3nbqA-1lpbB:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mt5 FATTY-ACID AMIDE
HYDROLASE

(Rattus
norvegicus) 		PF01425
(Amidase) 		5 GLY A 379
GLN A 273
LEU A 375
LEU A 447
ILE A 451
 None
 1.45A 3nbqA-1mt5A:
undetectable		 3nbqA-1mt5A:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 ARG A 949
GLU A 964
LEU A1015
LEU A1018
ILE A1009
 None
 1.46A 3nbqA-1ofeA:
undetectable		 3nbqA-1ofeA:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xr4 PUTATIVE CITRATE
LYASE ALPHA
CHAIN/CITRATE-ACP
TRANSFERASE

(Salmonella
enterica) 		PF04223
(CitF) 		5 GLY A 162
GLU A 202
LEU A 199
LEU A 161
ILE A 214
 None
 1.35A 3nbqA-1xr4A:
undetectable		 3nbqA-1xr4A:
22.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yix DEOXYRIBONUCLEASE
YCFH

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 THR A 163
GLY A 165
LEU A 167
LEU A 168
ILE A 174
 None
 1.17A 3nbqA-1yixA:
undetectable		 3nbqA-1yixA:
25.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bbv PROTEIN (BLACK
BEETLE VIRUS CAPSID
PROTEIN)

(Black beetle
virus) 		PF01829
(Peptidase_A6) 		5 THR A 315
GLY A 174
MET A 171
LEU A 313
ILE A 113
 None
 1.44A 3nbqA-2bbvA:
undetectable		 3nbqA-2bbvA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d4p HYPOTHETICAL PROTEIN
TTHA1254

(Thermus
thermophilus) 		PF09390
(DUF1999) 		5 GLY A  70
ARG A 103
LEU A  79
LEU A  76
ILE A  68
 None
 1.35A 3nbqA-2d4pA:
undetectable		 3nbqA-2d4pA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2een HYPOTHETICAL PROTEIN
PH1819

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		5 GLY A   8
GLU A 166
LEU A   6
LEU A 157
ILE A 136
 None
 1.43A 3nbqA-2eenA:
undetectable		 3nbqA-2eenA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ew7 PEPTIDE DEFORMYLASE

(Helicobacter
pylori) 		PF01327
(Pep_deformylase) 		5 GLY A  44
GLN A  70
GLU A  43
LEU A  47
ILE A  60
 None
 1.33A 3nbqA-2ew7A:
undetectable		 3nbqA-2ew7A:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 306
GLN A 224
ARG A 221
GLU A 303
LEU A 456
 None
 1.43A 3nbqA-2ix4A:
undetectable		 3nbqA-2ix4A:
23.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l6h FOCAL ADHESION
KINASE 1, LINKER,
PAXILLIN

(Gallus gallus;
unidentified) 		PF03623
(Focal_AT) 		5 GLY A  48
GLU A  46
LEU A  87
LEU A  84
ILE A  88
 None
 1.42A 3nbqA-2l6hA:
undetectable		 3nbqA-2l6hA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oca ATP-DEPENDENT DNA
HELICASE UVSW

(Escherichia
virus T4) 		PF00271
(Helicase_C)
PF04851
(ResIII) 		5 THR A  21
GLU A  19
LEU A  25
LEU A  54
ILE A  15
 None
 1.34A 3nbqA-2ocaA:
undetectable		 3nbqA-2ocaA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 GLY A1096
GLN A1166
ARG A1168
GLU A1196
MET A1197
 None
 0.84A 3nbqA-2oxfA:
25.5		 3nbqA-2oxfA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxf URIDINE
PHOSPHORYLASE

(Salmonella
enterica) 		PF01048
(PNP_UDP_1) 		5 THR A1095
GLN A1166
ARG A1168
GLU A1196
MET A1197
 None
 1.39A 3nbqA-2oxfA:
25.5		 3nbqA-2oxfA:
25.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzj TWO-COMPONENT
RESPONSE REGULATOR

(Clostridioides
difficile) 		PF00072
(Response_reg) 		5 GLY A  63
GLU A  55
MET A  81
LEU A  66
ILE A  70
 None
 1.43A 3nbqA-2qzjA:
3.3		 3nbqA-2qzjA:
16.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt6 2-OXOGLUTARATE
DECARBOXYLASE

(Mycolicibacterium
smegmatis) 		PF00198
(2-oxoacid_dh)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 GLY A 197
GLN A 274
LEU A 255
LEU A 196
ILE A 165
 None
 1.30A 3nbqA-2xt6A:
6.3		 3nbqA-2xt6A:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a7k HALORHODOPSIN

(Natronomonas
pharaonis) 		PF01036
(Bac_rhodopsin) 		5 THR A 207
GLY A 143
LEU A 141
LEU A 140
ILE A  67
 None
 1.19A 3nbqA-3a7kA:
undetectable		 3nbqA-3a7kA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bje NUCLEOSIDE
PHOSPHORYLASE,
PUTATIVE

(Trypanosoma
brucei) 		PF01048
(PNP_UDP_1) 		6 THR A 140
GLY A 142
GLN A 246
ARG A 248
GLU A 284
MET A 285
 R1P  A 401 (-3.0A)
URA  A 501 (-3.4A)
URA  A 501 (-3.0A)
URA  A 501 (-2.9A)
R1P  A 401 ( 4.6A)
R1P  A 401 ( 3.9A)
 0.31A 3nbqA-3bjeA:
23.3		 3nbqA-3bjeA:
26.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bq7 DIACYLGLYCEROL
KINASE DELTA

(Homo sapiens) 		PF07647
(SAM_2) 		5 GLY A  33
GLU A   9
LEU A  36
LEU A  37
ILE A  62
 None
 1.24A 3nbqA-3bq7A:
undetectable		 3nbqA-3bq7A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bs8 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Bacillus
subtilis) 		PF00202
(Aminotran_3) 		5 THR A 122
GLY A 149
GLU A 120
LEU A 152
LEU A 153
 PMP  A 431 ( 4.4A)
None
None
None
None
 1.14A 3nbqA-3bs8A:
undetectable		 3nbqA-3bs8A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e6q PUTATIVE
5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
ISOMERASE

(Pseudomonas
aeruginosa) 		PF02962
(CHMI) 		5 THR A  16
GLY A  19
LEU A  21
LEU A  22
ILE A   6
 None
 1.31A 3nbqA-3e6qA:
undetectable		 3nbqA-3e6qA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3edu SPECTRIN BETA CHAIN,
ERYTHROCYTE

(Homo sapiens) 		PF00435
(Spectrin) 		5 THR A1739
GLY A1743
GLN A1744
LEU A1702
ILE A1706
 None
 1.28A 3nbqA-3eduA:
undetectable		 3nbqA-3eduA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		8 THR A 141
GLY A 143
GLN A 217
ARG A 219
GLU A 248
MET A 249
LEU A 272
LEU A 273
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 (-3.1A)
BAU  A 400 (-3.0A)
None
BAU  A 400 (-3.8A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
 0.25A 3nbqA-3eufA:
48.9		 3nbqA-3eufA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3euf URIDINE
PHOSPHORYLASE 1

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 141
GLY A 143
LEU A 272
LEU A 273
ILE A 281
 PO4  A 401 ( 3.0A)
BAU  A 400 (-3.3A)
BAU  A 400 ( 4.2A)
BAU  A 400 ( 4.3A)
BAU  A 400 (-4.7A)
 0.73A 3nbqA-3eufA:
48.9		 3nbqA-3eufA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gas HEME OXYGENASE

(Helicobacter
pylori) 		PF01243
(Putative_PNPOx)
PF10615
(DUF2470) 		5 GLY A  19
GLU A  79
LEU A  20
LEU A  21
ILE A  45
 None
 1.40A 3nbqA-3gasA:
undetectable		 3nbqA-3gasA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gvp ADENOSYLHOMOCYSTEINA
SE 3

(Homo sapiens) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 THR A 245
GLY A 247
GLU A 244
LEU A 249
LEU A 224
 None
 1.44A 3nbqA-3gvpA:
2.8		 3nbqA-3gvpA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gwf CYCLOHEXANONE
MONOOXYGENASE

(Rhodococcus sp.
HI-31) 		PF00743
(FMO-like) 		5 THR A  35
GLY A  32
LEU A  27
LEU A  31
ILE A 452
 None
 1.40A 3nbqA-3gwfA:
undetectable		 3nbqA-3gwfA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h1l CYTOCHROME B

(Gallus gallus) 		PF00032
(Cytochrom_B_C)
PF00033
(Cytochrome_B) 		5 GLY C  49
GLN C  45
LEU C  51
LEU C  52
ILE C  80
 HEM  C 501 (-3.3A)
HEM  C 501 (-4.5A)
None
HEM  C 501 (-4.0A)
None
 1.02A 3nbqA-3h1lC:
undetectable		 3nbqA-3h1lC:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A1155
GLU A1152
LEU A1157
LEU A1158
ILE A1000
 None
 1.28A 3nbqA-3hngA:
undetectable		 3nbqA-3hngA:
22.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 GLY A 123
GLU A 119
LEU A 122
LEU A 126
ILE A 110
 None
 1.38A 3nbqA-3htxA:
undetectable		 3nbqA-3htxA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igf ALL4481 PROTEIN

(Nostoc sp. PCC
7120) 		PF02374
(ArsA_ATPase) 		5 THR A 138
GLY A 143
GLN A 337
LEU A 142
LEU A 209
 None
 1.42A 3nbqA-3igfA:
2.9		 3nbqA-3igfA:
22.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kcc CATABOLITE GENE
ACTIVATOR

(Escherichia
coli) 		PF00027
(cNMP_binding)
PF00325
(Crp) 		5 THR A 182
GLY A 184
GLU A 181
LEU A 187
ILE A 143
 None
None
CMP  A 303 ( 4.4A)
None
None
 1.13A 3nbqA-3kccA:
undetectable		 3nbqA-3kccA:
24.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3kvy URIDINE
PHOSPHORYLASE

(Bos taurus) 		PF01048
(PNP_UDP_1) 		9 THR A 140
GLY A 142
GLN A 216
ARG A 218
GLU A 247
MET A 248
LEU A 271
LEU A 272
ILE A 280
 SO4  A 311 ( 3.1A)
URA  A 312 (-3.3A)
URA  A 312 (-3.3A)
URA  A 312 (-2.9A)
R2B  A 313 ( 4.4A)
URA  A 312 ( 3.7A)
None
None
None
 0.15A 3nbqA-3kvyA:
46.7		 3nbqA-3kvyA:
75.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l0o TRANSCRIPTION
TERMINATION FACTOR
RHO

(Thermotoga
maritima) 		PF00006
(ATP-synt_ab)
PF07497
(Rho_RNA_bind)
PF07498
(Rho_N) 		5 THR A 250
GLU A 252
LEU A 211
LEU A 268
ILE A 213
 None
 1.34A 3nbqA-3l0oA:
undetectable		 3nbqA-3l0oA:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lez BETA-LACTAMASE

(Oceanobacillus
iheyensis) 		PF13354
(Beta-lactamase2) 		5 THR A 146
GLY A 148
LEU A 150
LEU A 151
ILE A 135
 None
 1.15A 3nbqA-3lezA:
undetectable		 3nbqA-3lezA:
25.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 GLY A 735
GLU A 733
LEU A 758
LEU A 848
ILE A 784
 PEG  A7001 ( 4.0A)
None
None
None
PEG  A7001 (-4.5A)
 1.23A 3nbqA-3lppA:
undetectable		 3nbqA-3lppA:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocj PUTATIVE EXPORTED
PROTEIN

(Bordetella
parapertussis) 		PF13847
(Methyltransf_31) 		5 GLY A  54
GLU A  85
LEU A  57
LEU A  58
ILE A 258
 PLM  A 305 (-3.5A)
None
None
None
None
 1.31A 3nbqA-3ocjA:
undetectable		 3nbqA-3ocjA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ooq AMIDOHYDROLASE

(Thermotoga
maritima) 		PF01979
(Amidohydro_1) 		5 THR A 290
GLU A 289
LEU A 294
LEU A 295
ILE A 301
 None
 1.40A 3nbqA-3ooqA:
undetectable		 3nbqA-3ooqA:
22.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		8 THR A 147
GLY A 149
GLN A 223
ARG A 225
GLU A 254
MET A 255
LEU A 278
LEU A 279
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 (-3.1A)
BAU  A 400 (-2.8A)
None
BAU  A 400 (-3.9A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
 0.36A 3nbqA-3p0fA:
44.2		 3nbqA-3p0fA:
62.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3p0f URIDINE
PHOSPHORYLASE 2

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 THR A 147
GLY A 149
LEU A 278
LEU A 279
ILE A 287
 BAU  A 400 (-4.5A)
BAU  A 400 (-3.5A)
BAU  A 400 ( 4.4A)
BAU  A 400 ( 4.5A)
BAU  A 400 (-4.6A)
 0.63A 3nbqA-3p0fA:
44.2		 3nbqA-3p0fA:
62.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp2 RHO
GTPASE-ACTIVATING
PROTEIN 27

(Homo sapiens) 		PF00169
(PH) 		5 GLY A 530
GLU A 528
LEU A 532
LEU A 561
ILE A 607
 None
 1.28A 3nbqA-3pp2A:
undetectable		 3nbqA-3pp2A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 THR A 166
GLU A 165
LEU A 167
LEU A 128
ILE A 124
 None
 1.31A 3nbqA-3qc0A:
undetectable		 3nbqA-3qc0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qc0 SUGAR ISOMERASE

(Sinorhizobium
meliloti) 		PF01261
(AP_endonuc_2) 		5 THR A 166
GLY A 168
GLU A 165
LEU A 167
ILE A 124
 None
 1.27A 3nbqA-3qc0A:
undetectable		 3nbqA-3qc0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sqw ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.07A 3nbqA-3sqwA:
2.6		 3nbqA-3sqwA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufc PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF01881
(Cas_Cas6) 		5 GLN X  27
GLU X  99
LEU X   7
LEU X  77
ILE X  55
 None
 1.37A 3nbqA-3ufcX:
undetectable		 3nbqA-3ufcX:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		5 THR A 207
GLU A 204
LEU A  99
LEU A  96
ILE A 105
 None
 1.42A 3nbqA-3wwxA:
undetectable		 3nbqA-3wwxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zwf ZINC
PHOSPHODIESTERASE
ELAC PROTEIN 1

(Homo sapiens) 		PF00753
(Lactamase_B)
PF12706
(Lactamase_B_2) 		5 THR A  41
GLY A  73
GLU A  39
LEU A  74
LEU A  75
 None
 1.29A 3nbqA-3zwfA:
undetectable		 3nbqA-3zwfA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4k ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF13234
(rRNA_proc-arch) 		5 THR A 935
GLY A 917
LEU A 916
LEU A 904
ILE A1013
 None
 1.44A 3nbqA-4a4kA:
undetectable		 3nbqA-4a4kA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4db4 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00271
(Helicase_C) 		5 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.16A 3nbqA-4db4A:
undetectable		 3nbqA-4db4A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		5 THR A 188
GLU A 187
LEU A 181
LEU A 263
ILE A 265
 FUC  A 411 ( 4.9A)
None
None
None
None
 1.33A 3nbqA-4fomA:
undetectable		 3nbqA-4fomA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i1u DEPHOSPHO-COA KINASE

(Burkholderia
vietnamiensis) 		PF01121
(CoaE) 		5 ARG A  37
GLU A  96
LEU A  90
LEU A  44
ILE A  38
 CL  A 304 (-4.4A)
None
None
CL  A 304 (-4.0A)
CL  A 304 (-4.6A)
 1.30A 3nbqA-4i1uA:
2.3		 3nbqA-4i1uA:
24.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ic6 PROTEASE DO-LIKE 8,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 GLY A 381
ARG A 432
GLU A 378
LEU A 439
ILE A 430
 None
 1.18A 3nbqA-4ic6A:
undetectable		 3nbqA-4ic6A:
23.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k6j WINGS APART-LIKE
PROTEIN HOMOLOG

(Homo sapiens) 		PF07814
(WAPL) 		5 GLY A1130
GLN A1134
LEU A1128
LEU A1127
ILE A 989
 None
 1.24A 3nbqA-4k6jA:
undetectable		 3nbqA-4k6jA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mp4 GLUTATHIONE
S-TRANSFERASE

(Acinetobacter
baumannii) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		5 THR A  22
GLY A  26
LEU A  77
LEU A  80
ILE A  76
 None
 1.30A 3nbqA-4mp4A:
undetectable		 3nbqA-4mp4A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5q TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 3

(Mus musculus) 		PF00023
(Ank)
PF12796
(Ank_2) 		5 THR A 287
GLU A 285
LEU A 281
LEU A 280
ILE A 235
 None
 1.44A 3nbqA-4n5qA:
undetectable		 3nbqA-4n5qA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nn3 TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Desulfovibrio
salexigens) 		PF03480
(DctP) 		5 THR A 231
GLN A 278
GLU A 233
LEU A 229
ILE A 285
 None
 1.33A 3nbqA-4nn3A:
undetectable		 3nbqA-4nn3A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum) 		PF07992
(Pyr_redox_2) 		5 GLN A 236
GLU A  86
LEU A 107
LEU A 109
ILE A  11
 None
None
None
None
FAD  A 301 (-4.9A)
 1.39A 3nbqA-4nteA:
undetectable		 3nbqA-4nteA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pd3 NONMUSCLE MYOSIN
HEAVY CHAIN B,
ALPHA-ACTININ A
CHIMERA PROTEIN

(Dictyostelium
discoideum;
Homo sapiens) 		PF00063
(Myosin_head)
PF00435
(Spectrin)
PF02736
(Myosin_N) 		5 THR A 479
GLN A 485
ARG A 669
GLU A 481
LEU A 661
 None
 1.28A 3nbqA-4pd3A:
undetectable		 3nbqA-4pd3A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppu CHORISMATE MUTASE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		no annotation 5 THR A 283
GLY A 285
GLU A 287
LEU A 107
ILE A 103
 None
 1.39A 3nbqA-4ppuA:
undetectable		 3nbqA-4ppuA:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		5 THR A 160
GLY A 270
LEU A 271
LEU A 272
ILE A 268
 None
MG  A 304 (-3.9A)
None
None
None
 1.44A 3nbqA-4q2eA:
undetectable		 3nbqA-4q2eA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8g PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF13423
(UCH_1) 		5 THR A 757
GLU A 759
LEU A 696
LEU A 771
ILE A 699
 None
 1.44A 3nbqA-4q8gA:
undetectable		 3nbqA-4q8gA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8h PAB-DEPENDENT
POLY(A)-SPECIFIC
RIBONUCLEASE SUBUNIT
PAN2

(Saccharomyces
cerevisiae) 		PF00929
(RNase_T)
PF13423
(UCH_1) 		5 THR A 757
GLU A 759
LEU A 696
LEU A 771
ILE A 699
 None
 1.45A 3nbqA-4q8hA:
undetectable		 3nbqA-4q8hA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qci ANTI-PDGF-BB
ANTIBODY - LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 THR A  77
GLN A  36
GLU A  80
LEU A  72
ILE A  20
 None
 1.35A 3nbqA-4qciA:
undetectable		 3nbqA-4qciA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN

(Pseudomonas
aeruginosa) 		no annotation 5 GLY B  64
GLN A 110
GLU A 104
LEU B  62
ILE B  67
 None
 1.26A 3nbqA-4r1dB:
undetectable		 3nbqA-4r1dB:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2w URIDINE
PHOSPHORYLASE

(Shewanella
oneidensis) 		PF01048
(PNP_UDP_1) 		6 THR A  91
GLY A  93
GLN A 163
ARG A 165
GLU A 193
MET A 194
 SO4  A 302 ( 3.0A)
None
None
None
GOL  A 303 (-4.9A)
GOL  A 303 (-3.5A)
 0.31A 3nbqA-4r2wA:
25.7		 3nbqA-4r2wA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		5 GLY A  94
GLN A 164
ARG A 166
GLU A 194
MET A 195
 None
None
None
None
GOL  A 301 (-4.0A)
 0.69A 3nbqA-4r31A:
25.5		 3nbqA-4r31A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r31 URIDINE
PHOSPHORYLASE

(Actinobacillus
succinogenes) 		PF01048
(PNP_UDP_1) 		5 THR A  93
GLN A 164
ARG A 166
GLU A 194
MET A 195
 None
None
None
None
GOL  A 301 (-4.0A)
 1.45A 3nbqA-4r31A:
25.5		 3nbqA-4r31A:
27.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tz0 ATP-DEPENDENT RNA
HELICASE MSS116,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		5 THR A 558
GLY A 560
LEU A 562
LEU A 563
ILE A 526
 None
 1.10A 3nbqA-4tz0A:
undetectable		 3nbqA-4tz0A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4umv ZINC-TRANSPORTING
ATPASE

(Shigella sonnei) 		PF00122
(E1-E2_ATPase)
PF00702
(Hydrolase) 		5 THR A 678
GLY A 428
LEU A 424
LEU A 427
ILE A 418
 None
 1.43A 3nbqA-4umvA:
2.7		 3nbqA-4umvA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wmo XEEL PROTEIN

(Xenopus laevis) 		no annotation 5 THR F 248
GLY F 243
GLU F 246
LEU F 196
ILE F 195
 None
 1.41A 3nbqA-4wmoF:
undetectable		 3nbqA-4wmoF:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wrr PUTATIVE
DIACYLGLYCEROL
KINASE

(Bacillus
anthracis) 		PF00781
(DAGK_cat) 		5 THR A 104
GLY A 106
GLN A 109
LEU A 105
ILE A  92
 None
 1.39A 3nbqA-4wrrA:
3.0		 3nbqA-4wrrA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bvr ALPHA-ACTININ-LIKE
PROTEIN 1

(Schizosaccharomyces
pombe) 		PF00307
(CH) 		5 THR A 108
GLY A 104
LEU A 105
LEU A 101
ILE A  89
 None
 1.42A 3nbqA-5bvrA:
undetectable		 3nbqA-5bvrA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dbo TRANSLATION
INITIATION FACTOR
EIF-2B-LIKE PROTEIN

(Chaetomium
thermophilum) 		PF01008
(IF-2B) 		5 GLY A 358
GLU A 360
LEU A 294
LEU A 391
ILE A 272
 None
 1.42A 3nbqA-5dboA:
undetectable		 3nbqA-5dboA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5doo PROTEIN LYSINE
METHYLTRANSFERASE 2

(Rickettsia
typhi) 		PF10119
(MethyTransf_Reg)
PF13847
(Methyltransf_31) 		5 THR A 252
GLY A 250
LEU A 295
LEU A 249
ILE A 145
 None
 1.43A 3nbqA-5dooA:
undetectable		 3nbqA-5dooA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f56 SINGLE-STRANDED-DNA-
SPECIFIC EXONUCLEASE

(Deinococcus
radiodurans) 		PF01368
(DHH)
PF02272
(DHHA1) 		5 GLY A 249
MET A 242
LEU A 291
LEU A 290
ILE A 275
 None
 1.13A 3nbqA-5f56A:
3.3		 3nbqA-5f56A:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g06 EXOSOME COMPLEX
COMPONENT RRP42

(Saccharomyces
cerevisiae) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 THR E  94
GLU E  93
LEU E  98
LEU E  99
ILE E 138
 None
 1.04A 3nbqA-5g06E:
undetectable		 3nbqA-5g06E:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ijj SPX DOMAIN

(Chaetomium
thermophilum) 		PF03105
(SPX) 		5 GLY A 100
GLU A  97
LEU A 102
LEU A 103
ILE A 170
 None
 1.38A 3nbqA-5ijjA:
undetectable		 3nbqA-5ijjA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		5 GLN A 165
ARG A 167
GLU A 195
MET A 196
ILE A 220
 URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
URA  A 304 (-4.3A)
 1.06A 3nbqA-5lhvA:
26.0		 3nbqA-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhv URIDINE
PHOSPHORYLASE

(Vibrio cholerae) 		PF01048
(PNP_UDP_1) 		6 THR A  93
GLY A  95
GLN A 165
ARG A 167
GLU A 195
MET A 196
 SO4  A 301 ( 2.9A)
URI  A 303 ( 3.4A)
URA  A 304 ( 2.9A)
URA  A 304 ( 2.9A)
URI  A 303 ( 4.6A)
URI  A 303 ( 3.7A)
 0.32A 3nbqA-5lhvA:
26.0		 3nbqA-5lhvA:
25.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lmg DNA TOPOISOMERASE
2-ASSOCIATED PROTEIN
PAT1

(Saccharomyces
cerevisiae) 		PF09770
(PAT1) 		5 GLY A 610
GLU A 607
LEU A 612
LEU A 613
ILE A 665
 None
 1.05A 3nbqA-5lmgA:
undetectable		 3nbqA-5lmgA:
24.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 THR A 599
GLY A 411
LEU A 597
LEU A 412
ILE A 641
 None
 1.20A 3nbqA-5mdnA:
undetectable		 3nbqA-5mdnA:
17.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		5 THR T3241
GLU T3243
LEU T3288
LEU T3287
ILE T3292
 None
 1.15A 3nbqA-5ojsT:
undetectable		 3nbqA-5ojsT:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ta1 GLYCOSIDE HYDROLASE

(Bacteroides
uniformis) 		no annotation 5 GLN A 593
GLU A 250
LEU A 563
LEU A 571
ILE A 603
 None
 1.24A 3nbqA-5ta1A:
undetectable		 3nbqA-5ta1A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uj7 ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 GLY E 213
GLU E 258
LEU E 211
LEU E 212
ILE E 208
 None
 1.37A 3nbqA-5uj7E:
undetectable		 3nbqA-5uj7E:
22.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujm ORIGIN RECOGNITION
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF13191
(AAA_16)
PF14630
(ORC5_C) 		5 GLY E 213
GLU E 258
LEU E 211
LEU E 212
ILE E 208
 None
 1.37A 3nbqA-5ujmE:
undetectable		 3nbqA-5ujmE:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uqj U6 SNRNA
PHOSPHODIESTERASE

(Saccharomyces
cerevisiae) 		PF09749
(HVSL) 		5 THR A 254
GLY A 256
GLU A 253
LEU A 258
LEU A 259
 None
 1.10A 3nbqA-5uqjA:
undetectable		 3nbqA-5uqjA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xh9 EXTRACELLULAR
INVERTASE

(Aspergillus
kawachii) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		5 THR A 392
GLY A 373
GLN A 387
ARG A 589
LEU A 371
 None
 1.40A 3nbqA-5xh9A:
undetectable		 3nbqA-5xh9A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6avh GH3.15 ACYL ACID
AMIDO SYNTHETASE

(Arabidopsis
thaliana) 		no annotation 5 GLY A 317
GLU A 284
LEU A 287
LEU A 319
ILE A 297
 None
 1.32A 3nbqA-6avhA:
undetectable		 3nbqA-6avhA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9m N-ALPHA-ACETYLTRANSF
ERASE 15, NATA
AUXILIARY SUBUNIT

(Homo sapiens) 		no annotation 5 THR A 229
GLY A 231
GLU A 228
LEU A 233
LEU A 234
 None
 1.18A 3nbqA-6c9mA:
undetectable		 3nbqA-6c9mA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elq CARBON MONOXIDE
DEHYDROGENASE

(Carboxydothermus
hydrogenoformans) 		no annotation 5 THR X 174
GLY X 179
GLU X 176
LEU X 209
ILE X 212
 None
 1.45A 3nbqA-6elqX:
undetectable		 3nbqA-6elqX:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 GLY A 122
GLU A 126
LEU A 121
LEU A 120
ILE A 106
 None
 1.45A 3nbqA-6ez8A:
undetectable		 3nbqA-6ez8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 5 GLY A1628
GLU A1582
LEU A1630
LEU A1627
ILE A1621
 None
 1.38A 3nbqA-6ez8A:
undetectable		 3nbqA-6ez8A:
7.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fv5 QUEUINE
TRNA-RIBOSYLTRANSFER
ASE ACCESSORY
SUBUNIT 2

(Mus musculus) 		no annotation 5 GLY A 283
GLU A 332
LEU A 335
LEU A 368
ILE A 364
 None
 1.26A 3nbqA-6fv5A:
undetectable		 3nbqA-6fv5A:
13.38