SIMILAR PATTERNS OF AMINO ACIDS FOR 3N9J_B_EAAB214_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8x PROTEIN (AML-1B)

(Escherichia
coli)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   6
GLY A  11
TYR A 110
GLY A 204
None
0.65A 3n9jB-1b8xA:
23.6
3n9jB-1b8xA:
24.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bud PROTEIN (ACUTOLYSIN
A)


(Deinagkistrodon
acutus)
PF01421
(Reprolysin)
4 VAL A 150
ARG A 187
ILE A  49
TYR A  44
None
0.82A 3n9jB-1budA:
undetectable
3n9jB-1budA:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e7n BETA-CRYSTALLIN B2

(Mus musculus)
PF00030
(Crystall)
4 TYR A  62
VAL A  37
GLY A  60
GLY A  40
None
0.80A 3n9jB-1e7nA:
undetectable
3n9jB-1e7nA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecg GLUTAMINE
PHOSPHORIBOSYLPYROPH
OSPHATE
AMIDOTRANSFERASE


(Escherichia
coli)
PF00156
(Pribosyltran)
PF13522
(GATase_6)
4 VAL A  12
GLY A   8
ILE A 232
GLY A  68
None
0.73A 3n9jB-1ecgA:
undetectable
3n9jB-1ecgA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fhe GLUTATHIONE
TRANSFERASE


(Fasciola
hepatica)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   6
GLY A  11
TYR A 110
GLY A 204
None
0.69A 3n9jB-1fheA:
24.6
3n9jB-1fheA:
29.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1gsq GLUTATHIONE
S-TRANSFERASE


(Todarodes
pacificus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   7
PHE A   8
GLY A  12
ARG A  13
None
GDN  A 203 (-4.5A)
None
GDN  A 203 (-4.9A)
0.50A 3n9jB-1gsqA:
25.6
3n9jB-1gsqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kgp RIBONUCLEOTIDE
REDUCTASE PROTEIN
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
4 TYR A 115
PHE A  70
ILE A 199
GLY A 175
None
0.73A 3n9jB-1kgpA:
undetectable
3n9jB-1kgpA:
20.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 TYR A   7
GLY A  12
ARG A  13
ILE A 104
TYR A 108
None
None
GSH  A 504 (-3.7A)
None
None
0.63A 3n9jB-1lbkA:
36.0
3n9jB-1lbkA:
97.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1lbk GLUTATHIONE
S-TRANSFERASE CLASS
PI CHIMAERA (CODA)


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
6 TYR A   7
PHE A   8
VAL A  10
GLY A  12
ARG A  13
ILE A 104
None
GSH  A 504 (-4.7A)
None
None
GSH  A 504 (-3.7A)
None
0.51A 3n9jB-1lbkA:
36.0
3n9jB-1lbkA:
97.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m4y ATP-DEPENDENT
PROTEASE HSLV


(Thermotoga
maritima)
PF00227
(Proteasome)
4 VAL A  34
GLY A  45
ILE A 122
GLY A  16
None
0.80A 3n9jB-1m4yA:
undetectable
3n9jB-1m4yA:
24.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omx ALPHA-1,4-N-ACETYLHE
XOSAMINYLTRANSFERASE
EXTL2


(Mus musculus)
PF09258
(Glyco_transf_64)
4 TYR A 209
VAL A 212
GLY A 262
GLY A 177
None
0.72A 3n9jB-1omxA:
undetectable
3n9jB-1omxA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pd2 HEMATOPOIETIC
PROSTAGLANDIN D
SYNTHASE


(Rattus
norvegicus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR 1   8
PHE 1   9
GLY 1  13
ARG 1  14
GSH  1 301 (-4.8A)
None
None
GSH  1 301 (-3.4A)
0.53A 3n9jB-1pd21:
23.9
3n9jB-1pd21:
28.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poj ISOASPARTYL
DIPEPTIDASE


(Escherichia
coli)
PF01979
(Amidohydro_1)
4 VAL A 152
GLY A 189
ARG A 186
GLY A 160
None
0.64A 3n9jB-1pojA:
undetectable
3n9jB-1pojA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pz3 ALPHA-L-ARABINOFURAN
OSIDASE


(Geobacillus
stearothermophilus)
PF06964
(Alpha-L-AF_C)
4 VAL A 413
ILE A  23
TYR A  24
GLY A 383
None
0.78A 3n9jB-1pz3A:
undetectable
3n9jB-1pz3A:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1n HYPOTHETICAL
ZINC-TYPE ALCOHOL
DEHYDROGENASE-LIKE
PROTEIN IN PRE5-FET4
INTERGENIC REGION


(Saccharomyces
cerevisiae)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
4 VAL A 168
GLY A 165
ILE A 321
GLY A 195
None
0.75A 3n9jB-1q1nA:
undetectable
3n9jB-1q1nA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qlb FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT


(Wolinella
succinogenes)
PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C)
4 PHE A 424
VAL A 420
GLY A 381
ILE A 375
None
0.77A 3n9jB-1qlbA:
undetectable
3n9jB-1qlbA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE III


(Paracoccus
denitrificans)
PF00510
(COX3)
4 PHE C  19
VAL C  61
GLY C  57
GLY C  20
None
0.78A 3n9jB-1qleC:
undetectable
3n9jB-1qleC:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2f PROTEIN
(RIBONUCLEOTIDE
REDUCTASE R2)


(Salmonella
enterica)
PF00268
(Ribonuc_red_sm)
4 TYR A 105
PHE A  60
ILE A 189
GLY A 165
None
0.81A 3n9jB-1r2fA:
undetectable
3n9jB-1r2fA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r5j PUTATIVE
PHOSPHOTRANSACETYLAS
E


(Streptococcus
pyogenes)
PF01515
(PTA_PTB)
4 VAL A  22
GLY A 122
ILE A 142
GLY A 111
None
0.80A 3n9jB-1r5jA:
undetectable
3n9jB-1r5jA:
21.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tu7 GLUTATHIONE
S-TRANSFERASE 2


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
None
GSH  A1001 (-4.8A)
None
None
None
0.50A 3n9jB-1tu7A:
30.5
3n9jB-1tu7A:
42.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1tu7 GLUTATHIONE
S-TRANSFERASE 2


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 106
GLY A 204
TYR A   7
GLY A  12
None
0.75A 3n9jB-1tu7A:
30.5
3n9jB-1tu7A:
42.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tuo PUTATIVE
PHOSPHOMANNOMUTASE


(Thermus
thermophilus)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 VAL A  95
GLY A 103
ILE A 128
GLY A 125
None
0.81A 3n9jB-1tuoA:
undetectable
3n9jB-1tuoA:
18.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA


(Schistosoma
mansoni)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A  10
PHE A  11
GLY A  15
ARG A  16
None
None
None
GSH  A 301 (-4.2A)
0.75A 3n9jB-1u3iA:
23.5
3n9jB-1u3iA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzr RIBONUCLEOTIDE
REDUCTASE R2-2 SMALL
SUBUNIT


(Mycobacterium
tuberculosis)
PF00268
(Ribonuc_red_sm)
4 TYR A 110
PHE A  65
ILE A 194
GLY A 170
None
0.81A 3n9jB-1uzrA:
undetectable
3n9jB-1uzrA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v40 GLUTATHIONE-REQUIRIN
G PROSTAGLANDIN D
SYNTHASE


(Homo sapiens)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   8
PHE A   9
GLY A  13
ARG A  14
None
O16  A3201 (-3.0A)
O16  A3201 ( 3.7A)
O16  A3201 ( 3.8A)
0.39A 3n9jB-1v40A:
24.4
3n9jB-1v40A:
27.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xco PHOSPHATE
ACETYLTRANSFERASE


(Bacillus
subtilis)
PF01515
(PTA_PTB)
4 VAL A  20
GLY A 120
ILE A 140
GLY A 109
None
0.77A 3n9jB-1xcoA:
undetectable
3n9jB-1xcoA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a18 CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN
CCMK HOMOLOG 4


(Synechocystis
sp. PCC 6803)
PF00936
(BMC)
4 VAL A  55
GLY A   8
ILE A  93
GLY A  50
None
0.81A 3n9jB-2a18A:
undetectable
3n9jB-2a18A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dr3 UPF0273 PROTEIN
PH0284


(Pyrococcus
horikoshii)
PF06745
(ATPase)
4 VAL A 172
GLY A 180
ILE A 191
GLY A  30
None
0.80A 3n9jB-2dr3A:
undetectable
3n9jB-2dr3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f7l 455AA LONG
HYPOTHETICAL
PHOSPHO-SUGAR MUTASE


(Sulfurisphaera
tokodaii)
PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III)
4 PHE A 133
VAL A  64
GLY A  60
GLY A  31
None
0.72A 3n9jB-2f7lA:
undetectable
3n9jB-2f7lA:
19.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2fhe GLUTATHIONE
S-TRANSFERASE


(Fasciola
hepatica)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   6
GLY A  11
TYR A 110
GLY A 204
None
0.54A 3n9jB-2fheA:
25.4
3n9jB-2fheA:
31.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE


(Sus scrofa)
PF02798
(GST_N)
PF14497
(GST_C_3)
7 TYR A   7
PHE A   8
VAL A  10
GLY A  12
ARG A  13
TYR A 106
GLY A 203
GTS  A 208 (-4.5A)
GTS  A 208 (-4.7A)
None
None
GTS  A 208 (-4.0A)
None
None
0.25A 3n9jB-2gsrA:
35.3
3n9jB-2gsrA:
82.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gsr CLASS PI GST
GLUTATHIONE
S-TRANSFERASE


(Sus scrofa)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 106
GLY A 203
TYR A   7
GLY A  12
None
None
GTS  A 208 (-4.5A)
None
0.65A 3n9jB-2gsrA:
35.3
3n9jB-2gsrA:
82.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnl GLUTATHIONE
S-TRANSFERASE 1


(Onchocerca
volvulus)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 TYR A  32
PHE A  33
GLY A  37
ARG A  38
ILE A 127
None
None
None
GSH  A 501 (-4.3A)
None
0.59A 3n9jB-2hnlA:
25.3
3n9jB-2hnlA:
28.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7c BETA-GLUCOSIDASE A

(Thermotoga
maritima)
PF00232
(Glyco_hydro_1)
4 PHE A 151
VAL A 212
GLY A 215
GLY A 155
None
0.64A 3n9jB-2j7cA:
undetectable
3n9jB-2j7cA:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kzx UNCHARACTERIZED
PROTEIN


(Ruminiclostridium
thermocellum)
PF04205
(FMN_bind)
4 TYR A   6
VAL A  26
GLY A   4
GLY A  29
None
0.80A 3n9jB-2kzxA:
undetectable
3n9jB-2kzxA:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r98 PUTATIVE
ACETYLGLUTAMATE
SYNTHASE


(Neisseria
gonorrhoeae)
PF00583
(Acetyltransf_1)
PF00696
(AA_kinase)
4 VAL A 359
GLY A 339
ILE A 289
GLY A 369
ACO  A   1 (-4.2A)
None
None
ACO  A   1 (-3.2A)
0.75A 3n9jB-2r98A:
undetectable
3n9jB-2r98A:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wan PULLULANASE

(Bacillus
acidopullulyticus)
PF00128
(Alpha-amylase)
PF02922
(CBM_48)
4 TYR A 210
VAL A 233
GLY A 208
GLY A 237
None
0.77A 3n9jB-2wanA:
undetectable
3n9jB-2wanA:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wkn FORMAMIDASE

(Delftia
acidovorans)
PF03069
(FmdA_AmdA)
4 GLY A 256
ILE A 260
TYR A 328
GLY A 360
None
0.75A 3n9jB-2wknA:
undetectable
3n9jB-2wknA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zp2 KINASE A INHIBITOR

(Bacillus
subtilis)
PF02682
(CT_C_D)
4 TYR A 142
PHE A 152
GLY A 154
GLY A 185
None
0.77A 3n9jB-2zp2A:
undetectable
3n9jB-2zp2A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqq METHYLGLUTACONYL-COA
HYDRATASE


(Homo sapiens)
PF00378
(ECH_1)
4 GLY A 220
ARG A 223
ILE A 165
GLY A 185
None
0.73A 3n9jB-2zqqA:
undetectable
3n9jB-2zqqA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bn4 CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK HOMOLOG 1


(Synechocystis
sp.)
PF00936
(BMC)
4 VAL A  53
GLY A   6
ILE A  91
GLY A  48
None
0.81A 3n9jB-3bn4A:
undetectable
3n9jB-3bn4A:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   7
GLY A  12
TYR A 111
GLY A 205
None
0.64A 3n9jB-3cruA:
25.8
3n9jB-3cruA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cru GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 111
GLY A 205
TYR A   7
GLY A  12
None
0.77A 3n9jB-3cruA:
25.8
3n9jB-3cruA:
29.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d0k PUTATIVE
POLY(3-HYDROXYBUTYRA
TE) DEPOLYMERASE
LPQC


(Bordetella
parapertussis)
no annotation 4 TYR A  98
PHE A 150
GLY A  59
GLY A 143
None
None
SO4  A 306 (-3.2A)
None
0.73A 3n9jB-3d0kA:
undetectable
3n9jB-3d0kA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6b GLUTARYL-COA
DEHYDROGENASE


(Burkholderia
pseudomallei)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 TYR A 373
VAL A 369
ILE A 210
GLY A 215
None
0.77A 3n9jB-3d6bA:
2.4
3n9jB-3d6bA:
21.16
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3gtu GLUTATHIONE
S-TRANSFERASE


(Homo sapiens)
PF00043
(GST_C)
PF02798
(GST_N)
4 TYR B  10
GLY B  15
ILE B 115
TYR B 119
None
0.38A 3n9jB-3gtuB:
27.0
3n9jB-3gtuB:
32.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8f CYTOSOL
AMINOPEPTIDASE


(Pseudomonas
putida)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
4 VAL A 484
GLY A 299
ARG A 302
GLY A 481
None
0.72A 3n9jB-3h8fA:
undetectable
3n9jB-3h8fA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibs CONSERVED
HYPOTHETICAL PROTEIN
BATB


(Bacteroides
thetaiotaomicron)
PF00092
(VWA)
4 TYR A 186
GLY A 140
ARG A 188
GLY A 115
None
0.54A 3n9jB-3ibsA:
undetectable
3n9jB-3ibsA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igx TRANSALDOLASE

(Francisella
tularensis)
PF00923
(TAL_FSA)
4 TYR A 217
PHE A 222
ILE A 143
GLY A 174
None
0.67A 3n9jB-3igxA:
undetectable
3n9jB-3igxA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m16 TRANSALDOLASE

(Oleispira
antarctica)
PF00923
(TAL_FSA)
4 TYR A 220
PHE A 225
ILE A 147
GLY A 178
None
0.82A 3n9jB-3m16A:
undetectable
3n9jB-3m16A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4r UNCHARACTERIZED
PROTEIN


(Thermoplasma
acidophilum)
PF00596
(Aldolase_II)
4 VAL A  31
GLY A  25
ILE A  67
GLY A  35
None
0.82A 3n9jB-3m4rA:
undetectable
3n9jB-3m4rA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mjo RIBONUCLEOTIDE
REDUCTASE SUBUNIT
R2F


(Corynebacterium
ammoniagenes)
PF00268
(Ribonuc_red_sm)
4 TYR A 115
PHE A  70
ILE A 199
GLY A 175
None
0.82A 3n9jB-3mjoA:
undetectable
3n9jB-3mjoA:
18.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1


(Mus musculus)
PF02798
(GST_N)
PF14497
(GST_C_3)
7 TYR A   7
PHE A   8
VAL A  10
GLY A  12
ARG A  13
TYR A 108
GLY A 205
None
GTB  A 210 (-4.5A)
None
None
GTB  A 210 (-3.9A)
GTB  A 210 (-4.1A)
GTB  A 210 (-3.7A)
0.35A 3n9jB-3o76A:
36.1
3n9jB-3o76A:
84.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3o76 GLUTATHIONE
S-TRANSFERASE P 1


(Mus musculus)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 108
GLY A 205
TYR A   7
GLY A  12
GTB  A 210 (-4.1A)
GTB  A 210 (-3.7A)
None
None
0.73A 3n9jB-3o76A:
36.1
3n9jB-3o76A:
84.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ogz UDP-SUGAR
PYROPHOSPHORYLASE


(Leishmania
major)
PF01704
(UDPGP)
4 VAL A 380
GLY A 378
ILE A 231
GLY A 225
None
0.69A 3n9jB-3ogzA:
undetectable
3n9jB-3ogzA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ssq CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN


(Thermosynechococcus
elongatus)
PF00936
(BMC)
4 VAL A  53
GLY A   6
ILE A  91
GLY A  48
None
0.81A 3n9jB-3ssqA:
undetectable
3n9jB-3ssqA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sss CARBON DIOXIDE
CONCENTRATING
MECHANISM PROTEIN


(Thermosynechococcus
elongatus)
PF00936
(BMC)
4 VAL A  53
GLY A   6
ILE A  91
GLY A  48
None
0.77A 3n9jB-3sssA:
undetectable
3n9jB-3sssA:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides)
PF02449
(Glyco_hydro_42)
5 TYR A 445
VAL A 489
GLY A 470
ARG A 356
GLY A 486
None
1.43A 3n9jB-3u7vA:
undetectable
3n9jB-3u7vA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrc GALLATE DIOXYGENASE

(Sphingomonas
paucimobilis)
PF02900
(LigB)
PF07746
(LigA)
4 TYR A  54
GLY A 125
ILE A  16
GLY A 188
None
0.81A 3n9jB-3wrcA:
undetectable
3n9jB-3wrcA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zx6 HAMP,
METHYL-ACCEPTING
CHEMOTAXIS PROTEIN I


(Archaeoglobus
fulgidus;
Escherichia
coli)
PF00015
(MCPsignal)
PF00672
(HAMP)
4 VAL A 131
GLY A 127
ILE A 232
GLY A 226
None
0.80A 3n9jB-3zx6A:
undetectable
3n9jB-3zx6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aio LIMIT DEXTRINASE

(Hordeum vulgare)
PF02922
(CBM_48)
PF11852
(DUF3372)
4 PHE A 539
ILE A 254
TYR A 506
GLY A 537
None
0.80A 3n9jB-4aioA:
undetectable
3n9jB-4aioA:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bg2 PATF

(Prochloron
didemni)
no annotation 4 PHE A  27
VAL A  29
TYR A  67
GLY A  65
None
0.80A 3n9jB-4bg2A:
undetectable
3n9jB-4bg2A:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e4r PHOSPHATE
ACETYLTRANSFERASE


(Staphylococcus
aureus)
PF01515
(PTA_PTB)
4 VAL A  20
GLY A 120
ILE A 140
GLY A 109
None
0.76A 3n9jB-4e4rA:
undetectable
3n9jB-4e4rA:
21.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4e ATP-DEPENDENT
PROTEASE SUBUNIT
HSLV


(Escherichia
coli)
PF00227
(Proteasome)
4 VAL A  34
GLY A  45
ILE A 122
GLY A  16
None
0.76A 3n9jB-4g4eA:
undetectable
3n9jB-4g4eA:
21.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxp BETA-GLUCOSIDASE
CHIMERIC PROTEIN


(Thermotoga
maritima;
Trichoderma
reesei)
PF00232
(Glyco_hydro_1)
4 PHE A 158
VAL A 219
GLY A 222
GLY A 162
None
0.75A 3n9jB-4gxpA:
undetectable
3n9jB-4gxpA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nte DEPH

(Chromobacterium
violaceum)
PF07992
(Pyr_redox_2)
4 GLY A  52
ARG A  56
ILE A  61
GLY A  49
None
None
None
NA  A 303 (-4.5A)
0.78A 3n9jB-4nteA:
undetectable
3n9jB-4nteA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nzk UNCHARACTERIZED
PROTEIN


([Eubacterium]
siraeum)
PF14286
(DHHW)
4 TYR A 108
GLY A 111
ILE A 164
GLY A 371
None
0.73A 3n9jB-4nzkA:
undetectable
3n9jB-4nzkA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oqj PKS

(Streptomyces
albus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc)
4 TYR A 227
PHE A 235
GLY A 239
GLY A 250
None
0.73A 3n9jB-4oqjA:
undetectable
3n9jB-4oqjA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ox7 CARBON
DIOXIDE-CONCENTRATIN
G MECHANISM PROTEIN
CCMK


(Synechococcus
elongatus)
PF00936
(BMC)
4 VAL A  53
GLY A   6
ILE A  91
GLY A  48
None
0.80A 3n9jB-4ox7A:
undetectable
3n9jB-4ox7A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM


(Blomia
tropicalis)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   8
VAL A  11
GLY A  13
ILE A 116
None
None
None
GSH  A 402 ( 4.5A)
0.67A 3n9jB-4q5nA:
25.6
3n9jB-4q5nA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF00623
(RNA_pol_Rpb1_2)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
4 PHE A 462
VAL B 891
GLY B 879
GLY A 464
None
0.72A 3n9jB-4qiwA:
undetectable
3n9jB-4qiwA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ql0 FILAMENTOUS
HEMAGGLUTININ
TRANSPORTER PROTEIN
FHAC


(Bordetella
pertussis)
PF03865
(ShlB)
PF08479
(POTRA_2)
PF17287
(POTRA_3)
4 TYR A 452
VAL A 449
GLY A 510
GLY A 494
None
0.78A 3n9jB-4ql0A:
undetectable
3n9jB-4ql0A:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r16 418AA LONG
HYPOTHETICAL
UDP-N-ACETYL-D-MANNO
SAMINURONIC ACID
DEHYDROGENASE


(Pyrococcus
horikoshii)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 VAL A   5
GLY A  28
ILE A  39
GLY A  12
None
0.75A 3n9jB-4r16A:
undetectable
3n9jB-4r16A:
19.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1d UNCHARACTERIZED
PROTEIN


(Pseudomonas
aeruginosa)
no annotation 4 TYR A 144
VAL A 139
GLY A  59
GLY A 208
None
0.81A 3n9jB-4r1dA:
undetectable
3n9jB-4r1dA:
17.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r20 CYTOCHROME P450
FAMILY 17
POLYPEPTIDE 2


(Danio rerio)
PF00067
(p450)
4 VAL A 304
GLY A 301
ARG A 246
ILE A 212
None
AER  A 602 ( 3.8A)
None
AER  A 602 (-3.2A)
0.70A 3n9jB-4r20A:
undetectable
3n9jB-4r20A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvc DEXTRANSUCRASE

(Leuconostoc
mesenteroides)
PF02324
(Glyco_hydro_70)
4 TYR A1909
VAL A1935
GLY A1907
GLY A1933
None
0.81A 3n9jB-4tvcA:
undetectable
3n9jB-4tvcA:
13.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uz1 NOTUM

(Homo sapiens)
PF03283
(PAE)
4 VAL A 238
GLY A 230
ILE A 161
GLY A 261
None
0.80A 3n9jB-4uz1A:
undetectable
3n9jB-4uz1A:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uzj NOTUM

(Drosophila
melanogaster)
PF03283
(PAE)
4 VAL A 243
GLY A 235
ILE A 160
GLY A 266
None
0.73A 3n9jB-4uzjA:
undetectable
3n9jB-4uzjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w66 GLUTATHIONE
S-TRANSFERASE DOMAIN
PROTEIN


(Haliangium
ochraceum)
PF14497
(GST_C_3)
4 TYR A   9
PHE A  10
VAL A  12
GLY A  14
None
0.19A 3n9jB-4w66A:
21.4
3n9jB-4w66A:
27.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbh PROTEIN NOTUM
HOMOLOG


(Homo sapiens)
PF03283
(PAE)
4 VAL A 238
GLY A 230
ILE A 161
GLY A 261
None
0.77A 3n9jB-4wbhA:
undetectable
3n9jB-4wbhA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wr4 GLUTATHIONE
S-TRANSFERASE
CLASS-MU 26 KDA
ISOZYME


(Schistosoma
japonicum)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A   6
GLY A  11
TYR A 110
GLY A 204
None
0.78A 3n9jB-4wr4A:
25.8
3n9jB-4wr4A:
27.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zfm PUTATIVE
6-PHOSPHO-BETA-GALAC
TOBIOSIDASE


(Geobacillus
stearothermophilus)
PF00232
(Glyco_hydro_1)
4 PHE A 155
VAL A 216
GLY A 219
GLY A 159
None
0.74A 3n9jB-4zfmA:
undetectable
3n9jB-4zfmA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zyj DNMZ

(Streptomyces
peucetius)
PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N)
4 VAL A  71
GLY A 111
ARG A 110
GLY A  68
None
0.78A 3n9jB-4zyjA:
undetectable
3n9jB-4zyjA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
4 VAL A 198
GLY A 292
ILE A 177
GLY A 308
None
0.49A 3n9jB-5cfaA:
undetectable
3n9jB-5cfaA:
18.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d73 GLUTATHIONE
S-TRANSFERASE


(Wuchereria
bancrofti)
PF02798
(GST_N)
PF14497
(GST_C_3)
5 TYR A   7
PHE A   8
GLY A  12
TYR A 106
GLY A 204
None
GSH  A 301 (-4.9A)
None
None
None
0.52A 3n9jB-5d73A:
30.7
3n9jB-5d73A:
42.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5d73 GLUTATHIONE
S-TRANSFERASE


(Wuchereria
bancrofti)
PF02798
(GST_N)
PF14497
(GST_C_3)
4 TYR A 106
GLY A 204
TYR A   7
GLY A  12
None
0.72A 3n9jB-5d73A:
30.7
3n9jB-5d73A:
42.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ewo STRUCTURAL PROTEIN

(Mamastrovirus 1)
PF12226
(Astro_capsid_p)
5 TYR A 588
PHE A 582
VAL A 543
GLY A 586
GLY A 546
None
1.10A 3n9jB-5ewoA:
undetectable
3n9jB-5ewoA:
22.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gai TAIL FIBER PROTEIN

(Salmonella
virus P22)
no annotation 4 VAL Y  26
GLY Y  71
ILE Y  73
GLY Y  29
None
0.79A 3n9jB-5gaiY:
undetectable
3n9jB-5gaiY:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5idi 1,4-BETA-D-GLUCAN
GLUCOHYDROLASE


(Thermotoga
neapolitana)
PF00232
(Glyco_hydro_1)
4 PHE A 149
VAL A 210
GLY A 213
GLY A 153
None
0.68A 3n9jB-5idiA:
undetectable
3n9jB-5idiA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ihw SERINE-ASPARTATE
REPEAT-CONTAINING
PROTEIN E


(Staphylococcus
aureus)
PF10425
(SdrG_C_C)
4 VAL A 473
GLY A 567
ILE A 452
GLY A 583
None
0.64A 3n9jB-5ihwA:
undetectable
3n9jB-5ihwA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j1l TOXR-ACTIVATED GENE
(TAGE)


(Helicobacter
pylori)
PF01551
(Peptidase_M23)
4 PHE A 208
VAL A 189
GLY A 228
GLY B 208
None
0.70A 3n9jB-5j1lA:
undetectable
3n9jB-5j1lA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jwf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE


(Porphyromonas
gingivalis)
PF10459
(Peptidase_S46)
4 PHE A 256
VAL A  73
GLY A  78
ARG A  77
None
0.81A 3n9jB-5jwfA:
undetectable
3n9jB-5jwfA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k0y EUKARYOTIC
INITIATION FACTOR 2
GAMMA SUBUNIT
(EIF2-GAMMA)


(Oryctolagus
cuniculus)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C)
4 VAL S 146
GLY S  58
ILE S 190
GLY S 161
None
0.79A 3n9jB-5k0yS:
undetectable
3n9jB-5k0yS:
18.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ACYL-COA
DEHYDROGENASE


(Clostridioides
difficile)
no annotation 4 TYR C  68
VAL C  72
GLY C 244
GLY C  83
None
0.77A 3n9jB-5ol2C:
undetectable
3n9jB-5ol2C:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C


(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii)
PF00384
(Molybdopterin)
PF01493
(GXGXG)
4 TYR B 207
GLY C 202
ILE C 251
GLY C 221
None
0.79A 3n9jB-5t5iB:
undetectable
3n9jB-5t5iB:
17.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE


(Pseudomonas
aeruginosa)
no annotation 4 PHE A  53
VAL A  56
GLY A 389
ILE A 391
None
0.80A 3n9jB-5uxnA:
undetectable
3n9jB-5uxnA:
20.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vn4 ADENINE
PHOSPHORIBOSYLTRANSF
ERASE, PUTATIVE


(Trypanosoma
brucei)
PF00156
(Pribosyltran)
4 TYR A  10
PHE A 200
GLY A 177
GLY A 174
None
0.81A 3n9jB-5vn4A:
undetectable
3n9jB-5vn4A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cv0 SPIKE GLYCOPROTEIN

(Avian
coronavirus)
no annotation 4 GLY A 560
ILE A 562
TYR A 525
GLY A 507
None
0.81A 3n9jB-6cv0A:
undetectable
3n9jB-6cv0A:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f42 DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC1
DNA-DIRECTED RNA
POLYMERASE III
SUBUNIT RPC2


(Saccharomyces
cerevisiae)
no annotation 4 PHE A 512
VAL B 921
GLY B 909
GLY A 514
None
0.65A 3n9jB-6f42A:
undetectable
3n9jB-6f42A:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gsw MU CLASS GLUTATHIONE
S-TRANSFERASE OF
ISOENZYME 3-3


(Rattus rattus)
PF00043
(GST_C)
PF02798
(GST_N)
4 TYR A   6
VAL A   9
GLY A  11
ILE A 111
None
None
GPS  A 221 (-3.5A)
GPS  A 221 (-4.5A)
0.61A 3n9jB-6gswA:
25.6
3n9jB-6gswA:
30.00