SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8Z_B_FLPB1701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b33 ALLOPHYCOCYANIN,
ALPHA CHAIN

(Mastigocladus
laminosus) 		PF00502
(Phycobilisome) 		5 LEU A 159
LEU A  84
GLY A 128
ALA A 127
SER A 130
 None
BLA  A 201 ( 4.7A)
None
None
None
 0.98A 3n8zB-1b33A:
undetectable		 3n8zB-1b33A:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dq3 ENDONUCLEASE

(Pyrococcus
furiosus) 		PF09061
(Stirrup)
PF09062
(Endonuc_subdom)
PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		5 LEU A 261
ILE A 243
GLY A 245
ALA A 244
LEU A 317
 None
 0.86A 3n8zB-1dq3A:
1.1		 3n8zB-1dq3A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6y METHYL-COENZYME M
REDUCTASE I BETA
SUBUNIT
METHYL-COENZYME M
REDUCTASE SUBUNIT
GAMMA

(Methanosarcina
barkeri) 		PF02240
(MCR_gamma)
PF02241
(MCR_beta)
PF02783
(MCR_beta_N) 		5 ARG C3111
LEU C3057
LEU B2397
GLY B2317
ALA B2318
 None
 1.03A 3n8zB-1e6yC:
undetectable		 3n8zB-1e6yC:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e6z CHITINASE B

(Serratia
marcescens) 		PF00704
(Glyco_hydro_18) 		5 VAL A 377
TRP A 324
ILE A 339
ALA A 340
LEU A 345
 None
 1.06A 3n8zB-1e6zA:
0.0		 3n8zB-1e6zA:
22.61
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 SCL  A 700 (-3.9A)
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.37A 3n8zB-1ebvA:
62.0		 3n8zB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jct GLUCARATE
DEHYDRATASE

(Escherichia
coli) 		PF13378
(MR_MLE_C) 		5 VAL A 132
LEU A 136
LEU A  84
TYR A  80
ALA A 118
 None
 1.09A 3n8zB-1jctA:
0.0		 3n8zB-1jctA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jgc BACTERIOFERRITIN

(Rhodobacter
capsulatus) 		PF00210
(Ferritin) 		5 VAL A 131
LEU A 134
TYR A  25
GLY A  93
LEU A  98
 None
 1.07A 3n8zB-1jgcA:
undetectable		 3n8zB-1jgcA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jy1 TYROSYL-DNA
PHOSPHODIESTERASE

(Homo sapiens) 		PF06087
(Tyr-DNA_phospho) 		5 VAL A 227
TYR A 537
ALA A 332
SER A 334
LEU A 335
 None
 0.82A 3n8zB-1jy1A:
0.0		 3n8zB-1jy1A:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		5 VAL A 146
LEU A 145
GLY A 140
ALA A 136
LEU A 154
 None
 1.07A 3n8zB-1od6A:
undetectable		 3n8zB-1od6A:
13.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhg ATP-DEPENDENT
HELICASE PCRA

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 0.99A 3n8zB-1qhgA:
1.7		 3n8zB-1qhgA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhh PROTEIN (PCRA
(SUBUNIT))

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY B 250
ALA A  31
LEU B 282
 None
 1.01A 3n8zB-1qhhA:
undetectable		 3n8zB-1qhhA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urj MAJOR DNA-BINDING
PROTEIN

(Human
alphaherpesvirus
1) 		PF00747
(Viral_DNA_bp) 		5 LEU A 156
LEU A  55
ILE A  31
ALA A  35
SER A  38
 None
 1.09A 3n8zB-1urjA:
undetectable		 3n8zB-1urjA:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vcg ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Thermus
thermophilus) 		PF01070
(FMN_dh) 		6 VAL A 329
LEU A  33
LEU A 310
GLY A 271
ALA A 274
LEU A 277
 None
 1.45A 3n8zB-1vcgA:
undetectable		 3n8zB-1vcgA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 LEU A 185
ILE A 237
ALA A 241
SER A 243
LEU A 244
 None
 1.00A 3n8zB-1yfmA:
undetectable		 3n8zB-1yfmA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a0u INITIATION FACTOR 2B

(Leishmania
major) 		PF01008
(IF-2B) 		5 VAL A 179
TYR A 294
GLY A 163
ALA A 164
LEU A 168
 None
 1.05A 3n8zB-2a0uA:
0.0		 3n8zB-2a0uA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a35 HYPOTHETICAL PROTEIN
PA4017

(Pseudomonas
aeruginosa) 		PF08732
(HIM1) 		5 LEU A   9
LEU A  73
GLY A  12
ALA A  13
LEU A  22
 None
 1.02A 3n8zB-2a35A:
undetectable		 3n8zB-2a35A:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7z 3-KETOACYL-COA
THIOLASE 2

(Arabidopsis
thaliana) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  82
LEU A 303
ILE A 100
GLY A 162
ALA A 163
 None
 1.05A 3n8zB-2c7zA:
undetectable		 3n8zB-2c7zA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ctz O-ACETYL-L-HOMOSERIN
E SULFHYDRYLASE

(Thermus
thermophilus) 		PF01053
(Cys_Met_Meta_PP) 		5 LEU A 199
LEU A 235
ILE A 257
ALA A 260
LEU A  88
 None
 1.03A 3n8zB-2ctzA:
undetectable		 3n8zB-2ctzA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 0.97A 3n8zB-2dphA:
undetectable		 3n8zB-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 223
 None
 1.01A 3n8zB-2elcA:
undetectable		 3n8zB-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 TYR A 238
LEU A  74
GLY A 290
ALA A 289
LEU A 285
 None
 1.01A 3n8zB-2elcA:
undetectable		 3n8zB-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2elc ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE

(Thermus
thermophilus) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N) 		5 VAL A 215
TYR A 238
LEU A  74
GLY A 290
ALA A 289
 None
 0.81A 3n8zB-2elcA:
undetectable		 3n8zB-2elcA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fiy PROTEIN FDHE HOMOLOG

(Pseudomonas
aeruginosa) 		PF04216
(FdhE) 		5 LEU A 125
LEU A 140
GLY A 157
ALA A 158
LEU A  55
 None
 1.08A 3n8zB-2fiyA:
undetectable		 3n8zB-2fiyA:
19.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gk9 PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE II,
GAMMA

(Homo sapiens) 		PF01504
(PIP5K) 		5 LEU A 126
TYR A 189
GLY A  54
ALA A  56
SER A  58
 None
 1.01A 3n8zB-2gk9A:
undetectable		 3n8zB-2gk9A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j3h NADP-DEPENDENT
OXIDOREDUCTASE P1

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 LEU A  48
ILE A 103
GLY A  82
SER A  84
LEU A 100
 None
 1.05A 3n8zB-2j3hA:
undetectable		 3n8zB-2j3hA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2c GLUCOSE-6-PHOSPHATE
ISOMERASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00342
(PGI) 		5 LEU A 534
ILE A 542
GLY A 540
ALA A 541
LEU A  91
 None
 1.00A 3n8zB-2o2cA:
0.1		 3n8zB-2o2cA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00106
(adh_short)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A1538
ILE A1641
GLY A1595
ALA A1596
LEU A1600
 None
 0.91A 3n8zB-2pffA:
undetectable		 3n8zB-2pffA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pjr PROTEIN (HELICASE
PCRA)

(Geobacillus
stearothermophilus) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  40
LEU A  41
GLY A 250
ALA A  31
LEU A 282
 None
 0.96A 3n8zB-2pjrA:
undetectable		 3n8zB-2pjrA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A  55
ILE A  88
GLY A  92
ALA A  91
SER A  94
 None
 1.00A 3n8zB-2pozA:
undetectable		 3n8zB-2pozA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qve TYROSINE AMINOMUTASE

(Streptomyces
globisporus) 		PF00221
(Lyase_aromatic) 		5 LEU A 216
LEU A 136
ILE A 109
ALA A 112
LEU A 335
 None
 0.98A 3n8zB-2qveA:
undetectable		 3n8zB-2qveA:
20.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wua ACETOACETYL COA
THIOLASE

(Helianthus
annuus) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 VAL A  80
LEU A 301
ILE A  98
GLY A 160
ALA A 161
 None
 1.04A 3n8zB-2wuaA:
undetectable		 3n8zB-2wuaA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA

(Homo sapiens;
Rattus
norvegicus) 		PF01602
(Adaptin_N) 		5 TYR A 583
LEU B 507
ILE B 525
GLY B 523
LEU B 482
 None
 1.04A 3n8zB-2xa7A:
undetectable		 3n8zB-2xa7A:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zb3 PROSTAGLANDIN
REDUCTASE 2

(Mus musculus) 		PF00107
(ADH_zinc_N)
PF16884
(ADH_N_2) 		5 VAL A 314
GLY A 165
ALA A 166
SER A 169
LEU A 170
 None
NDP  A 900 (-3.1A)
NDP  A 900 (-3.4A)
None
None
 1.06A 3n8zB-2zb3A:
undetectable		 3n8zB-2zb3A:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt7 TRNA
(URACIL-5-)-METHYLTR
ANSFERASE

(Escherichia
coli) 		PF05958
(tRNA_U5-meth_tr) 		5 ARG A  96
LEU A 105
LEU A 139
ILE A  92
GLY A  94
 None
 0.99A 3n8zB-3bt7A:
undetectable		 3n8zB-3bt7A:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f2i ALR0221 PROTEIN

(Nostoc sp. PCC
7120) 		PF00300
(His_Phos_1) 		5 LEU A  40
TRP A 156
ILE A   6
GLY A 136
ALA A 135
 None
 1.06A 3n8zB-3f2iA:
undetectable		 3n8zB-3f2iA:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fo5 THIOESTERASE,
ADIPOSE ASSOCIATED,
ISOFORM BFIT2

(Homo sapiens) 		PF01852
(START) 		5 ARG A 449
VAL A 544
LEU A 395
GLY A 531
LEU A 443
 1PE  A   2 (-2.8A)
None
None
None
None
 0.98A 3n8zB-3fo5A:
undetectable		 3n8zB-3fo5A:
18.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 162
ILE C 276
GLY C 279
ALA C 280
SER C 283
 None
 1.05A 3n8zB-3gi8C:
undetectable		 3n8zB-3gi8C:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 VAL A 301
ILE A 307
ALA A 385
SER A 388
LEU A 389
 None
 1.02A 3n8zB-3hz6A:
undetectable		 3n8zB-3hz6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8b XYLULOSE KINASE

(Bifidobacterium
adolescentis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 LEU A 350
TYR A 347
ILE A 335
GLY A 339
ALA A 338
 None
 0.92A 3n8zB-3i8bA:
undetectable		 3n8zB-3i8bA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kty PROBABLE
METHYLTRANSFERASE

(Bordetella
pertussis) 		PF00588
(SpoU_methylase) 		5 VAL A 118
LEU A  81
GLY A 104
ALA A 103
LEU A 165
 None
 1.08A 3n8zB-3ktyA:
undetectable		 3n8zB-3ktyA:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3let ADENOSINE
MONOPHOSPHATE-PROTEI
N TRANSFERASE VOPS

(Vibrio
parahaemolyticus) 		PF02661
(Fic) 		5 LEU A 318
ILE A 345
GLY A 343
ALA A 342
LEU A 214
 None
 1.04A 3n8zB-3letA:
undetectable		 3n8zB-3letA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lfu DNA HELICASE II

(Escherichia
coli) 		PF00580
(UvrD-helicase)
PF13361
(UvrD_C) 		5 VAL A  38
LEU A  39
GLY A 247
ALA A  29
LEU A 279
 None
 1.01A 3n8zB-3lfuA:
undetectable		 3n8zB-3lfuA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 LEU B 266
LEU B 202
ILE B 152
GLY B 138
ALA B 139
 None
 0.89A 3n8zB-3mcaB:
undetectable		 3n8zB-3mcaB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 LEU A 894
TYR A 891
ILE A 855
ALA A 854
LEU A 880
 None
 0.78A 3n8zB-3psfA:
undetectable		 3n8zB-3psfA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		5 LEU A 894
TYR A 891
ILE A 855
ALA A 854
LEU A 880
 None
 0.79A 3n8zB-3psiA:
undetectable		 3n8zB-3psiA:
18.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.08A 3n8zB-3r5gA:
undetectable		 3n8zB-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
TYR A  36
TYR A  50
GLY A  57
ALA A  58
 None
 1.00A 3n8zB-3tfyA:
undetectable		 3n8zB-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		5 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.02A 3n8zB-3tw8A:
undetectable		 3n8zB-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vyl L-RIBULOSE
3-EPIMERASE

(Mesorhizobium
loti) 		PF01261
(AP_endonuc_2) 		5 LEU A 146
LEU A  88
ILE A 106
ALA A 109
SER A 126
 None
 0.99A 3n8zB-3vylA:
undetectable		 3n8zB-3vylA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 LEU A 239
ILE A 643
GLY A 646
ALA A 647
LEU A 651
 None
DMU  A1776 ( 4.9A)
None
DMU  A1776 ( 4.1A)
DMU  A1775 ( 4.9A)
 0.94A 3n8zB-4a01A:
0.5		 3n8zB-4a01A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		5 LEU A1737
GLY A1842
ALA A1841
SER A1844
LEU A1868
 None
 1.02A 3n8zB-4asiA:
undetectable		 3n8zB-4asiA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0e F1 CAPSULE-ANCHORING
PROTEIN

(Yersinia pestis) 		PF13954
(PapC_N) 		5 VAL A  38
LEU A 113
LEU A  83
ALA A 119
LEU A 120
 None
 1.02A 3n8zB-4b0eA:
undetectable		 3n8zB-4b0eA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4boc DNA-DIRECTED RNA
POLYMERASE,
MITOCHONDRIAL

(Homo sapiens) 		PF00940
(RNA_pol)
PF14700
(RPOL_N) 		5 LEU A 297
LEU A 234
GLY A 270
ALA A 272
LEU A 280
 None
 1.05A 3n8zB-4bocA:
undetectable		 3n8zB-4bocA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bsn EXPORTIN-1

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1)
PF08767
(CRM1_C) 		5 VAL A 520
LEU A 517
ILE A 504
GLY A 502
LEU A 497
 None
 1.07A 3n8zB-4bsnA:
undetectable		 3n8zB-4bsnA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c13 UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--L-LYSINE LIGASE

(Staphylococcus
aureus) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 TYR A 247
GLY A 216
ALA A 218
SER A 220
LEU A 221
 None
KCX  A 219 ( 4.5A)
KCX  A 219 ( 3.1A)
KCX  A 219 ( 4.3A)
None
 0.92A 3n8zB-4c13A:
undetectable		 3n8zB-4c13A:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4df1 OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Pyrobaculum
neutrophilum) 		PF00215
(OMPdecase) 		5 LEU A   7
ILE A 176
GLY A 178
ALA A  10
LEU A  11
 None
BMP  A 301 ( 4.6A)
BMP  A 301 (-3.4A)
BMP  A 301 ( 3.9A)
None
 1.06A 3n8zB-4df1A:
undetectable		 3n8zB-4df1A:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dll 2-HYDROXY-3-OXOPROPI
ONATE REDUCTASE

(Polaromonas sp.
JS666) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		5 LEU A 288
LEU A 309
ILE A 208
GLY A 211
ALA A 212
 None
 0.99A 3n8zB-4dllA:
undetectable		 3n8zB-4dllA:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		5 VAL A 147
LEU A 148
GLY A 191
ALA A 192
LEU A 139
 None
 1.02A 3n8zB-4dwqA:
undetectable		 3n8zB-4dwqA:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e69 2-DEHYDRO-3-DEOXYGLU
CONOKINASE

(Oceanicola
granulosus) 		PF00294
(PfkB) 		5 LEU A 145
ILE A 179
GLY A 182
ALA A 183
SER A 186
 None
 0.81A 3n8zB-4e69A:
undetectable		 3n8zB-4e69A:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.64A 3n8zB-4eelA:
undetectable		 3n8zB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f6c AUSA REDUCTASE
DOMAIN PROTEIN

(Staphylococcus
aureus) 		PF07993
(NAD_binding_4) 		5 VAL A2229
TYR A2203
GLY A2133
ALA A2132
LEU A2056
 None
 1.06A 3n8zB-4f6cA:
undetectable		 3n8zB-4f6cA:
21.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4p AMINO ACID ABC
TRANSPORTER, AMINO
ACID-BINDING/PERMEAS
E PROTEIN

(Enterococcus
faecalis) 		PF00497
(SBP_bac_3) 		5 LEU A 128
TYR A 125
ILE A 177
ALA A 114
LEU A 196
 None
 0.91A 3n8zB-4g4pA:
undetectable		 3n8zB-4g4pA:
16.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4heq FLAVODOXIN

(Desulfovibrio
gigas) 		PF00258
(Flavodoxin_1) 		5 VAL A  53
LEU A   5
GLY A  45
ALA A  81
LEU A  83
 None
 0.96A 3n8zB-4heqA:
undetectable		 3n8zB-4heqA:
17.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hka TRYPTOPHAN
2,3-DIOXYGENASE

(Drosophila
melanogaster) 		PF03301
(Trp_dioxygenase) 		5 VAL A 189
LEU A 199
GLY A 275
ALA A 276
LEU A 295
 None
 0.91A 3n8zB-4hkaA:
undetectable		 3n8zB-4hkaA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky0 PROTON/GLUTAMATE
SYMPORTER, SDF
FAMILY

(Thermococcus
kodakarensis) 		PF00375
(SDF) 		5 VAL A 153
LEU A 154
GLY A 309
ALA A 310
LEU A 284
 None
 1.02A 3n8zB-4ky0A:
undetectable		 3n8zB-4ky0A:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4luj OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Methanocaldococcus
jannaschii) 		PF00215
(OMPdecase) 		5 VAL A  47
LEU A  24
ILE A 209
GLY A 211
ALA A  27
 None
None
BMP  A 301 ( 4.4A)
BMP  A 301 (-3.5A)
BMP  A 301 ( 3.7A)
 1.05A 3n8zB-4lujA:
undetectable		 3n8zB-4lujA:
16.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mwa 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Bacillus
anthracis) 		PF04551
(GcpE) 		5 VAL D 183
LEU D 252
ILE D 225
GLY D 223
ALA D 224
 None
 0.86A 3n8zB-4mwaD:
undetectable		 3n8zB-4mwaD:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oye 425AA LONG
HYPOTHETICAL PROTON
GLUTAMATE SYMPORT
PROTEIN

(Pyrococcus
horikoshii) 		PF00375
(SDF) 		5 VAL A 151
LEU A 152
GLY A 306
ALA A 307
LEU A 282
 None
 1.03A 3n8zB-4oyeA:
undetectable		 3n8zB-4oyeA:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 121
VAL A 350
LEU A 353
TYR A 356
LEU A 385
TYR A 386
TRP A 388
GLY A 527
ALA A 528
SER A 531
LEU A 532
 BOG  A 604 ( 3.7A)
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
None
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.57A 3n8zB-4ph9A:
58.6		 3n8zB-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qfh GLUCOSE-6-PHOSPHATE
ISOMERASE

(Trypanosoma
cruzi) 		PF00342
(PGI) 		6 LEU A 535
LEU A 350
ILE A 543
GLY A 541
ALA A 542
LEU A  92
 None
 1.32A 3n8zB-4qfhA:
0.6		 3n8zB-4qfhA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpm MITOTIC CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 908
ILE A 918
GLY A 916
SER A 950
LEU A 947
 None
 0.97A 3n8zB-4qpmA:
undetectable		 3n8zB-4qpmA:
18.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tvo MALATE DEHYDROGENASE

(Mycobacterium
tuberculosis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ARG A  92
LEU A 329
ILE A 110
GLY A 108
LEU A 103
 None
 1.06A 3n8zB-4tvoA:
undetectable		 3n8zB-4tvoA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u8u GLOBIN A CHAIN
GLOBIN B CHAIN

(Glossoscolex
paulistus) 		PF00042
(Globin) 		5 VAL B   5
LEU A  68
ILE A  32
GLY A  34
ALA A  35
 None
 1.07A 3n8zB-4u8uB:
undetectable		 3n8zB-4u8uB:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wky BETA-KETOACYL
SYNTHASE

(Streptomyces
albus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 LEU A  42
ILE A 377
GLY A 375
ALA A 374
LEU A 367
 None
 1.05A 3n8zB-4wkyA:
undetectable		 3n8zB-4wkyA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 VAL A 432
LEU A 433
LEU A 302
ILE A 309
ALA A 250
 None
 1.01A 3n8zB-4xgjA:
undetectable		 3n8zB-4xgjA:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 VAL B 261
LEU B 258
ILE B 388
ALA B 298
LEU B 301
 None
 0.92A 3n8zB-4yryB:
undetectable		 3n8zB-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ztd PROLIFERATING CELL
NUCLEAR ANTIGEN

(Homo sapiens) 		PF00705
(PCNA_N)
PF02747
(PCNA_C) 		5 VAL A  15
LEU A  16
LEU A  99
ILE A  88
LEU A  52
 None
 1.06A 3n8zB-4ztdA:
undetectable		 3n8zB-4ztdA:
18.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che PROTEIN FLUORESCENT
IN BLUE LIGHT,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13424
(TPR_12) 		5 VAL E 270
LEU E 271
ILE E 290
GLY E 288
ALA E 289
 None
 0.81A 3n8zB-5cheE:
undetectable		 3n8zB-5cheE:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5co8 NUCLEASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 LEU A 325
LEU A 109
ILE A 303
GLY A 305
ALA A 304
 None
 1.08A 3n8zB-5co8A:
undetectable		 3n8zB-5co8A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csa ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00364
(Biotin_lipoyl)
PF08326
(ACC_central) 		5 VAL A 634
LEU A 694
ILE A 582
GLY A 584
ALA A 586
 None
 0.98A 3n8zB-5csaA:
undetectable		 3n8zB-5csaA:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5csl ACETYL-COA
CARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF08326
(ACC_central) 		5 VAL A 634
LEU A 694
ILE A 582
GLY A 584
ALA A 586
 None
 0.94A 3n8zB-5cslA:
undetectable		 3n8zB-5cslA:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cwv NUCLEOPORIN NUP192

(Chaetomium
thermophilum) 		PF11894
(Nup192) 		5 VAL A1596
LEU A1597
LEU A1729
GLY A1647
ALA A1648
 None
 1.06A 3n8zB-5cwvA:
undetectable		 3n8zB-5cwvA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5elp NRPS/PKS PROTEIN

(Bacillus
amyloliquefaciens) 		no annotation 5 LEU C 419
ILE C 368
GLY C 366
ALA C 365
LEU C 355
 None
 1.08A 3n8zB-5elpC:
undetectable		 3n8zB-5elpC:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grm STIMULATOR OF
INTERFERON GENES
PROTEIN

(Rattus
norvegicus) 		no annotation 5 LEU A 259
LEU A 330
GLY A 255
ALA A 256
LEU A 190
 None
 0.96A 3n8zB-5grmA:
undetectable		 3n8zB-5grmA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 VAL A  27
LEU A  65
ILE A 268
GLY A 271
ALA A 272
 None
 0.72A 3n8zB-5hn4A:
undetectable		 3n8zB-5hn4A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hss LINALOOL
DEHYDRATASE/ISOMERAS
E

(Castellaniella
defragrans) 		no annotation 5 LEU A 152
ILE A 123
ALA A 183
SER A 186
LEU A 187
 None
 0.99A 3n8zB-5hssA:
undetectable		 3n8zB-5hssA:
20.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 ARG A 120
VAL A 349
LEU A 352
TYR A 355
LEU A 384
TYR A 385
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 ID8  A 601 ( 4.4A)
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 4.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.61A 3n8zB-5ikrA:
58.7		 3n8zB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j84 DIHYDROXY-ACID
DEHYDRATASE

(Rhizobium
leguminosarum) 		PF00920
(ILVD_EDD) 		5 VAL A 488
LEU A 296
GLY A 393
ALA A 390
LEU A 519
 None
 1.06A 3n8zB-5j84A:
undetectable		 3n8zB-5j84A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jrt TANKYRASE-2

(Homo sapiens) 		PF07647
(SAM_2) 		5 VAL A 905
LEU A 904
LEU A 885
ILE A 927
GLY A 929
 None
 1.06A 3n8zB-5jrtA:
undetectable		 3n8zB-5jrtA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		5 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.77A 3n8zB-5k7lA:
undetectable		 3n8zB-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lnx ACYL-COA
DEHYDROGENASE

(Bacillus
subtilis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 LEU A  39
ILE A  84
GLY A  82
ALA A  80
SER A  78
 None
 1.06A 3n8zB-5lnxA:
undetectable		 3n8zB-5lnxA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nug CYTOPLASMIC DYNEIN 1
HEAVY CHAIN 1

(Homo sapiens) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		5 VAL A4309
LEU A4312
TRP A4320
GLY A4152
ALA A4155
 None
 1.04A 3n8zB-5nugA:
undetectable		 3n8zB-5nugA:
8.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5od2 BIFUNCTIONAL
ADP-SPECIFIC
GLUCOKINASE/PHOSPHOF
RUCTOKINASE

(Methanocaldococcus
jannaschii) 		no annotation 5 VAL A 347
LEU A 315
ILE A 329
GLY A 331
ALA A 332
 None
 0.83A 3n8zB-5od2A:
undetectable		 3n8zB-5od2A:
10.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tp4 AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Burkholderia
ambifaria) 		PF01546
(Peptidase_M20) 		5 ARG A  93
VAL A  97
LEU A 101
TRP A  49
ALA A  20
 EDO  A 506 (-3.6A)
None
None
None
EDO  A 506 ( 4.9A)
 0.95A 3n8zB-5tp4A:
undetectable		 3n8zB-5tp4A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xap PROTEIN TRANSLOCASE
SUBUNIT SECD

(Deinococcus
radiodurans) 		PF02355
(SecD_SecF)
PF07549
(Sec_GG) 		5 LEU A 348
LEU A 723
ILE A 296
GLY A 299
ALA A 300
 None
None
OLC  A 807 (-4.4A)
OLC  A 807 ( 4.5A)
OLC  A 807 ( 3.8A)
 0.78A 3n8zB-5xapA:
undetectable		 3n8zB-5xapA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbk IMPORTIN-4

(Homo sapiens) 		no annotation 6 VAL D 803
LEU D 804
ILE D 839
GLY D 836
ALA D 838
LEU D 772
 None
 1.23A 3n8zB-5xbkD:
undetectable		 3n8zB-5xbkD:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 5 VAL B   7
LEU B 182
ILE B  74
GLY B  42
LEU B 233
 None
 0.90A 3n8zB-5y35B:
undetectable		 3n8zB-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygr DIAMINOPROPIONATE
AMMONIA LYASE

(Salmonella
enterica) 		no annotation 5 LEU A 382
ILE A 351
GLY A 328
ALA A 350
SER A 332
 None
 1.04A 3n8zB-5ygrA:
undetectable		 3n8zB-5ygrA:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 3

(Homo sapiens) 		no annotation 5 ILE A1053
GLY A1046
ALA A1045
SER A1037
LEU A1039
 None
 1.06A 3n8zB-6en4A:
undetectable		 3n8zB-6en4A:
10.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 VAL A 142
LEU A 143
ILE A 156
GLY A 155
LEU A 128
 None
 1.04A 3n8zB-6gbnA:
undetectable		 3n8zB-6gbnA:
undetectable