SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8Y_B_SALB900

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8s CHLOROPEROXIDASE F

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		4 VAL A 240
LEU A 209
ILE A 104
ALA A 115
 None
 0.92A 3n8yB-1a8sA:
0.0		 3n8yB-1a8sA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ck7 PROTEIN (GELATINASE
A)

(Homo sapiens) 		PF00040
(fn2)
PF00045
(Hemopexin)
PF00413
(Peptidase_M10)
PF01471
(PG_binding_1) 		4 VAL A 648
LEU A 640
ILE A 613
ALA A 612
 None
 0.97A 3n8yB-1ck7A:
0.4		 3n8yB-1ck7A:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		5 VAL A 349
LEU A 352
TYR A 355
ILE A 523
ALA A 527
 SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
SCL  A 700 (-3.4A)
SCL  A 700 (-2.9A)
 0.46A 3n8yB-1ebvA:
61.4		 3n8yB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eyy ALDEHYDE
DEHYDROGENASE

(Vibrio harveyi) 		PF00171
(Aldedh) 		4 VAL A 171
LEU A 204
ILE A 188
ALA A 155
 None
 0.93A 3n8yB-1eyyA:
0.0		 3n8yB-1eyyA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hjr HOLLIDAY JUNCTION
RESOLVASE (RUVC)

(Escherichia
coli) 		PF02075
(RuvC) 		4 VAL A 125
LEU A 128
ILE A  18
ALA A 146
 None
 1.00A 3n8yB-1hjrA:
undetectable		 3n8yB-1hjrA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hle HORSE LEUKOCYTE
ELASTASE INHIBITOR

(Equus caballus) 		PF00079
(Serpin) 		4 LEU A 112
TYR A 244
ILE B 374
ALA A 347
 None
 0.93A 3n8yB-1hleA:
0.0		 3n8yB-1hleA:
19.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks8 ENDO-B-1,4-GLUCANASE

(Nasutitermes
takasagoensis) 		PF00759
(Glyco_hydro_9) 		4 VAL A 260
LEU A 263
TYR A 273
ALA A 235
 None
 0.69A 3n8yB-1ks8A:
0.0		 3n8yB-1ks8A:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ku1 ARF
GUANINE-NUCLEOTIDE
EXCHANGE FACTOR 2

(Saccharomyces
cerevisiae) 		PF01369
(Sec7) 		4 VAL A 698
LEU A 701
ILE A 642
ALA A 641
 None
 0.92A 3n8yB-1ku1A:
undetectable		 3n8yB-1ku1A:
16.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mhy METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylosinus
trichosporium) 		PF02964
(MeMO_Hyd_G) 		4 VAL G 139
LEU G 140
ILE G 111
ALA G 102
 None
 0.99A 3n8yB-1mhyG:
undetectable		 3n8yB-1mhyG:
16.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		4 VAL A1181
LEU A1184
ILE A1196
ALA A1118
 None
 0.93A 3n8yB-1ofeA:
0.5		 3n8yB-1ofeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 VAL A 207
LEU A 208
ILE A 322
ALA A 408
 None
 0.73A 3n8yB-1pgpA:
undetectable		 3n8yB-1pgpA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r4w GLUTATHIONE
S-TRANSFERASE,
MITOCHONDRIAL

(Rattus
norvegicus) 		PF01323
(DSBA) 		4 VAL A 106
LEU A 103
ILE A 138
ALA A 142
 None
 0.90A 3n8yB-1r4wA:
undetectable		 3n8yB-1r4wA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sum PHOSPHATE TRANSPORT
SYSTEM PROTEIN PHOU
HOMOLOG 2

(Thermotoga
maritima) 		PF01895
(PhoU) 		4 VAL B 155
LEU B 158
ILE B 119
ALA B 123
 None
 0.79A 3n8yB-1sumB:
undetectable		 3n8yB-1sumB:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szn ALPHA-GALACTOSIDASE

(Trichoderma
reesei) 		PF16499
(Melibiase_2) 		4 VAL A  86
LEU A  89
ILE A  38
ALA A  34
 None
 0.86A 3n8yB-1sznA:
undetectable		 3n8yB-1sznA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1um8 ATP-DEPENDENT CLP
PROTEASE ATP-BINDING
SUBUNIT CLPX

(Helicobacter
pylori) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL A 237
LEU A 241
ILE A 216
ALA A 175
 None
 0.92A 3n8yB-1um8A:
undetectable		 3n8yB-1um8A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vc4 INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00218
(IGPS) 		4 VAL A 177
LEU A 158
ILE A  49
ALA A 232
 None
 0.91A 3n8yB-1vc4A:
undetectable		 3n8yB-1vc4A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vko INOSITOL-3-PHOSPHATE
SYNTHASE

(Caenorhabditis
elegans) 		PF01658
(Inos-1-P_synth)
PF07994
(NAD_binding_5) 		4 VAL A 233
LEU A  68
ILE A 215
ALA A 276
 None
 0.87A 3n8yB-1vkoA:
undetectable		 3n8yB-1vkoA:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vrq SARCOSINE OXIDASE
ALPHA SUBUNIT

(Corynebacterium
sp. U-96) 		PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF12831
(FAD_oxidored)
PF13510
(Fer2_4) 		4 VAL A 535
LEU A 536
ILE A 508
ALA A 497
 None
 0.98A 3n8yB-1vrqA:
undetectable		 3n8yB-1vrqA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vsq MANNOSE-SPECIFIC
PHOSPHOTRANSFERASE
ENZYME IIB COMPONENT

(Escherichia
coli) 		PF03830
(PTSIIB_sorb) 		4 VAL C 250
LEU C 253
ILE C 164
ALA C 167
 None
 0.76A 3n8yB-1vsqC:
undetectable		 3n8yB-1vsqC:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzx GLUTATHIONE
S-TRANSFERASE KAPPA
1

(Homo sapiens) 		PF01323
(DSBA) 		4 VAL A 106
LEU A 103
ILE A 138
ALA A 142
 None
 0.83A 3n8yB-1yzxA:
undetectable		 3n8yB-1yzxA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z45 GAL10 BIFUNCTIONAL
PROTEIN

(Saccharomyces
cerevisiae) 		PF01263
(Aldose_epim)
PF16363
(GDP_Man_Dehyd) 		4 VAL A 315
LEU A 316
ILE A 149
ALA A 142
 None
 0.90A 3n8yB-1z45A:
undetectable		 3n8yB-1z45A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		4 VAL A  75
LEU A  76
ILE A   7
ALA A  42
 None
 0.86A 3n8yB-2arkA:
undetectable		 3n8yB-2arkA:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d7m FILAMIN-C

(Homo sapiens) 		PF00630
(Filamin) 		4 LEU A  30
TYR A  74
ILE A  26
ALA A 102
 None
 0.96A 3n8yB-2d7mA:
undetectable		 3n8yB-2d7mA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ecr FLAVIN REDUCTASE
COMPONENT (HPAC) OF
4-HYDROXYPHENYLACETA
TE 3-MONOOXYGENASE

(Thermus
thermophilus) 		PF01613
(Flavin_Reduct) 		4 VAL A  16
LEU A  70
TYR A 142
ALA A  82
 None
 0.98A 3n8yB-2ecrA:
undetectable		 3n8yB-2ecrA:
16.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ga8 HYPOTHETICAL 39.9
KDA PROTEIN

(Saccharomyces
cerevisiae) 		PF07728
(AAA_5) 		4 VAL A  11
LEU A  15
ILE A 155
ALA A 156
 None
None
None
CME  A  45 ( 3.8A)
 0.97A 3n8yB-2ga8A:
undetectable		 3n8yB-2ga8A:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0a TRANSCRIPTIONAL
REGULATOR

(Thermus
thermophilus) 		PF13377
(Peripla_BP_3) 		4 VAL A  88
LEU A  89
ILE A 124
ALA A 304
 None
 0.94A 3n8yB-2h0aA:
undetectable		 3n8yB-2h0aA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i4c BICARBONATE
TRANSPORTER

(Synechocystis
sp. PCC 6803) 		PF13379
(NMT1_2) 		4 VAL A  93
LEU A  63
ILE A 294
ALA A  77
 None
 0.97A 3n8yB-2i4cA:
undetectable		 3n8yB-2i4cA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lxi RNA-BINDING PROTEIN
10

(Homo sapiens) 		PF00076
(RRM_1) 		4 VAL A  75
LEU A  68
ILE A  18
ALA A  47
 None
 0.95A 3n8yB-2lxiA:
undetectable		 3n8yB-2lxiA:
11.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pef SERINE PROTEASE
INHIBITOR

(Caldanaerobacter
subterraneus) 		PF00079
(Serpin) 		4 LEU A 139
TYR A 267
ILE A 405
ALA A 375
 None
 0.91A 3n8yB-2pefA:
undetectable		 3n8yB-2pefA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 VAL A 185
LEU A 186
ILE A 162
ALA A 158
 None
 1.01A 3n8yB-2pvqA:
undetectable		 3n8yB-2pvqA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qb6 EXOPOLYPHOSPHATASE

(Saccharomyces
cerevisiae) 		PF01368
(DHH)
PF02833
(DHHA2) 		4 VAL A  91
LEU A  92
ILE A  43
ALA A  44
 None
 0.95A 3n8yB-2qb6A:
undetectable		 3n8yB-2qb6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		4 VAL A 813
LEU A 814
ILE A 874
ALA A 731
 None
 1.00A 3n8yB-2qobA:
undetectable		 3n8yB-2qobA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq1 MOLYBDENUM COFACTOR
BIOSYNTHESIS MOG

(Aquifex
aeolicus) 		PF00994
(MoCF_biosynth) 		4 VAL A  10
LEU A  73
ILE A 141
ALA A  29
 None
 0.92A 3n8yB-2qq1A:
undetectable		 3n8yB-2qq1A:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 VAL A1841
LEU A1836
TYR A1839
ILE A1777
 None
None
None
UNX  A  11 ( 4.8A)
 1.01A 3n8yB-2rexA:
undetectable		 3n8yB-2rexA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlc TYPE 2
RIBOSOME-INACTIVATIN
G PROTEIN CINNAMOMIN
III

(Cinnamomum
camphora) 		PF00161
(RIP)
PF00652
(Ricin_B_lectin) 		4 VAL A  69
LEU A  67
ILE A 162
ALA A 166
 None
 0.84A 3n8yB-2vlcA:
undetectable		 3n8yB-2vlcA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium) 		PF16990
(CBM_35) 		4 VAL A  71
LEU A 110
ILE A 124
ALA A  55
 None
 0.91A 3n8yB-2w3jA:
undetectable		 3n8yB-2w3jA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5z HISTONE-LYSINE
N-METHYLTRANSFERASE
HRX

(Homo sapiens) 		PF00856
(SET) 		4 LEU A3940
TYR A3942
ILE A3928
ALA A3902
 None
 0.99A 3n8yB-2w5zA:
undetectable		 3n8yB-2w5zA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 141
LEU A 138
ILE A 222
ALA A 218
 None
 0.92A 3n8yB-2y7jA:
undetectable		 3n8yB-2y7jA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ybq METHYLTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00590
(TP_methylase) 		4 VAL A 247
LEU A 182
ILE A 194
ALA A 195
 None
 0.88A 3n8yB-2ybqA:
undetectable		 3n8yB-2ybqA:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yut PUTATIVE SHORT-CHAIN
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF00106
(adh_short) 		4 VAL A 117
LEU A  70
ILE A   5
ALA A  73
 None
None
None
NAP  A 500 (-4.1A)
 0.99A 3n8yB-2yutA:
undetectable		 3n8yB-2yutA:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0r PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA0547

(Thermus
thermophilus) 		PF11572
(DUF3234) 		4 VAL A  93
LEU A  96
TYR A  65
ILE A  32
 None
 0.98A 3n8yB-2z0rA:
undetectable		 3n8yB-2z0rA:
11.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhh CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II BETA
CHAIN

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 124
LEU A 121
ILE A 203
ALA A 199
 None
 0.96A 3n8yB-3bhhA:
undetectable		 3n8yB-3bhhA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3czm L-LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  54
TYR A  85
ILE A  26
ALA A  98
 NAD  A 401 (-4.2A)
None
None
NAD  A 401 (-3.4A)
 0.91A 3n8yB-3czmA:
undetectable		 3n8yB-3czmA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fza GLUTAREDOXIN

(Populus tremula
x Populus
tremuloides) 		PF00462
(Glutaredoxin) 		4 VAL A  64
LEU A  68
TYR A  24
ALA A  11
 None
 0.94A 3n8yB-3fzaA:
undetectable		 3n8yB-3fzaA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hka URONATE ISOMERASE

(Bacillus
halodurans) 		no annotation 4 VAL A 400
LEU A 403
ILE A 373
ALA A 374
 None
 0.94A 3n8yB-3hkaA:
undetectable		 3n8yB-3hkaA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ia0 ETHANOLAMINE
UTILIZATION PROTEIN
EUTS

(Escherichia
coli) 		PF00936
(BMC) 		4 LEU A 100
TYR A 103
ILE A  54
ALA A  55
 None
 0.99A 3n8yB-3ia0A:
undetectable		 3n8yB-3ia0A:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuu PHOSPHORIBOSYLAMINOI
MIDAZOLE CARBOXYLASE
CATALYTIC SUBUNIT
PURE

(Yersinia pestis) 		PF00731
(AIRC) 		4 VAL A  34
LEU A  35
ILE A  72
ALA A 134
 None
 0.92A 3n8yB-3kuuA:
undetectable		 3n8yB-3kuuA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lgj SINGLE-STRANDED
DNA-BINDING PROTEIN

(Bartonella
henselae) 		PF00436
(SSB) 		4 VAL A  75
LEU A 110
ILE A  64
ALA A  65
 None
 0.93A 3n8yB-3lgjA:
undetectable		 3n8yB-3lgjA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lnt 2,3-BISPHOSPHOGLYCER
ATE-DEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Burkholderia
pseudomallei) 		PF00300
(His_Phos_1) 		4 VAL A 159
LEU A 162
ILE A 179
ALA A 181
 None
 0.85A 3n8yB-3lntA:
undetectable		 3n8yB-3lntA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nda SERPIN-2

(Ixodes ricinus) 		PF00079
(Serpin) 		4 LEU A  92
TYR A 226
ILE A 360
ALA A 330
 None
 0.93A 3n8yB-3ndaA:
undetectable		 3n8yB-3ndaA:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3om9 LACTATE
DEHYDROGENASE

(Toxoplasma
gondii) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		4 VAL A  54
TYR A  85
ILE A  26
ALA A  98
 NAD  A 701 (-4.1A)
None
None
NAD  A 701 (-3.4A)
 0.95A 3n8yB-3om9A:
undetectable		 3n8yB-3om9A:
20.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vqf E3 UBIQUITIN-PROTEIN
LIGASE LNX

(Mus musculus) 		PF00595
(PDZ) 		4 VAL A   6
LEU A  82
ILE A  19
ALA A  41
 None
 0.99A 3n8yB-3vqfA:
undetectable		 3n8yB-3vqfA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqo UNCHARACTERIZED
PROTEIN MJ1311

(Methanocaldococcus
jannaschii) 		PF01261
(AP_endonuc_2) 		4 VAL A 244
LEU A 248
ILE A 257
ALA A 221
 None
 0.76A 3n8yB-3wqoA:
undetectable		 3n8yB-3wqoA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b60 FIBRONECTIN-BINDING
PROTEIN A

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 VAL A 251
LEU A 247
ILE A 208
ALA A 225
 None
 0.93A 3n8yB-4b60A:
undetectable		 3n8yB-4b60A:
18.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bju N-ACETYLGLUCOSAMINE-
PHOSPHATE MUTASE

(Aspergillus
fumigatus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I) 		4 VAL A 334
LEU A 354
ILE A 317
ALA A 313
 None
 1.00A 3n8yB-4bjuA:
undetectable		 3n8yB-4bjuA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bm1 MANGANESE PEROXIDASE
4

(Pleurotus
ostreatus) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 VAL A 169
LEU A 172
ILE A  51
ALA A 162
 HEM  A 500 ( 4.7A)
HEM  A 500 (-3.3A)
None
None
 0.99A 3n8yB-4bm1A:
undetectable		 3n8yB-4bm1A:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmw EXTRACELLULAR
HAEM-BINDING PROTEIN

(Streptomyces
reticuli) 		PF03928
(Haem_degrading) 		4 VAL A 153
LEU A 154
ILE A 132
ALA A  38
 None
 0.98A 3n8yB-4bmwA:
undetectable		 3n8yB-4bmwA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		4 VAL A 397
LEU A 402
ILE A 422
ALA A 352
 None
 0.90A 3n8yB-4chbA:
undetectable		 3n8yB-4chbA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecj GLUTATHIONE
S-TRANSFERASE

(Pseudomonas
aeruginosa) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A  93
LEU A  97
ILE A  73
ALA A  76
 None
 0.99A 3n8yB-4ecjA:
undetectable		 3n8yB-4ecjA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h0o ACETATE KINASE

(Entamoeba
histolytica) 		PF00871
(Acetate_kinase) 		4 VAL A 179
LEU A 183
ILE A 194
ALA A 196
 None
 1.00A 3n8yB-4h0oA:
undetectable		 3n8yB-4h0oA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ihq FLAI ATPASE

(Sulfolobus
acidocaldarius) 		PF00437
(T2SSE) 		4 VAL A 378
LEU A 371
ILE A 337
ALA A 345
 None
 0.99A 3n8yB-4ihqA:
undetectable		 3n8yB-4ihqA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jkz TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Mycolicibacterium
smegmatis) 		PF00440
(TetR_N)
PF16859
(TetR_C_11) 		4 LEU A  60
TYR A  51
ILE A  36
ALA A  40
 None
 0.95A 3n8yB-4jkzA:
undetectable		 3n8yB-4jkzA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 VAL A 204
LEU A 213
ILE A 397
ALA A 163
 None
 0.95A 3n8yB-4krfA:
undetectable		 3n8yB-4krfA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrh COPN

(Chlamydia
pneumoniae) 		PF07201
(HrpJ) 		4 VAL A 150
LEU A 149
ILE A 128
ALA A 167
 None
 1.00A 3n8yB-4nrhA:
1.5		 3n8yB-4nrhA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o0m CIRCADIAN CLOCK
PROTEIN KINASE KAIC

(Thermosynechococcus
elongatus) 		PF06745
(ATPase) 		4 VAL A 298
LEU A 302
ILE A 346
ALA A 316
 None
 0.92A 3n8yB-4o0mA:
undetectable		 3n8yB-4o0mA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 VAL B 264
LEU B 267
TYR B 270
ILE B 410
 None
 0.89A 3n8yB-4ourB:
undetectable		 3n8yB-4ourB:
22.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 350
LEU A 353
TYR A 356
ALA A 528
 IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 (-3.4A)
 0.45A 3n8yB-4ph9A:
32.9		 3n8yB-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1h LMO0741 PROTEIN

(Listeria
monocytogenes) 		PF00392
(GntR) 		4 VAL A  35
LEU A  38
ILE A  13
ALA A  52
 None
 1.01A 3n8yB-4r1hA:
1.9		 3n8yB-4r1hA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7y MINICHROMOSOME
MAINTENANCE PROTEIN
MCM, CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus;
Sulfolobus
solfataricus) 		PF00493
(MCM)
PF14551
(MCM_N)
PF17207
(MCM_OB) 		4 VAL A1341
LEU A1344
TYR A1755
ILE A1875
 None
 0.92A 3n8yB-4r7yA:
undetectable		 3n8yB-4r7yA:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21

(Pyrococcus
furiosus) 		PF00493
(MCM) 		4 VAL A 341
LEU A 344
TYR A 755
ILE A 875
 None
 1.00A 3n8yB-4r7zA:
undetectable		 3n8yB-4r7zA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK

(Mycobacterium
tuberculosis) 		PF00012
(HSP70) 		4 VAL D 213
LEU D 212
ILE D 258
ALA D 230
 None
 0.92A 3n8yB-4rtfD:
1.0		 3n8yB-4rtfD:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w82 FATTY ACID SYNTHASE

(Homo sapiens) 		PF00107
(ADH_zinc_N) 		4 VAL A1814
LEU A1813
ILE A1687
ALA A1655
 None
 0.90A 3n8yB-4w82A:
undetectable		 3n8yB-4w82A:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9s EPOXIDE HYDROLASE

(Solanum
tuberosum) 		PF00561
(Abhydrolase_1) 		4 VAL A  82
LEU A  81
ILE A  30
ALA A 111
 None
 0.92A 3n8yB-4y9sA:
undetectable		 3n8yB-4y9sA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		4 VAL B 261
LEU B 258
ILE B 388
ALA B 298
 None
 0.79A 3n8yB-4yryB:
undetectable		 3n8yB-4yryB:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z9c PERTUSSIS TOXIN-LIKE
SUBUNIT ARTA

(Escherichia
coli) 		PF02917
(Pertussis_S1) 		4 VAL A 220
LEU A 221
ILE A 182
ALA A 184
 None
 1.01A 3n8yB-4z9cA:
undetectable		 3n8yB-4z9cA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zk3 SERPIN B3

(Homo sapiens) 		PF00079
(Serpin) 		4 LEU A 101
TYR A 236
ILE A 373
ALA A 343
 None
 0.86A 3n8yB-4zk3A:
undetectable		 3n8yB-4zk3A:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5x LIMITING
CO2-INDUCIBLE
PROTEIN LCIC

(Chlamydomonas
reinhardtii) 		no annotation 4 VAL A 101
LEU A 102
ILE A 291
ALA A 319
 None
 0.83A 3n8yB-5b5xA:
undetectable		 3n8yB-5b5xA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5che PROTEIN FLUORESCENT
IN BLUE LIGHT,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13424
(TPR_12) 		4 VAL E 270
LEU E 271
ILE E 290
ALA E 289
 None
 0.82A 3n8yB-5cheE:
undetectable		 3n8yB-5cheE:
15.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5da8 60 KDA CHAPERONIN

(Chlorobaculum
tepidum) 		PF00118
(Cpn60_TCP1) 		4 VAL A 177
LEU A 379
ILE A 158
ALA A 399
 None
 0.85A 3n8yB-5da8A:
0.9		 3n8yB-5da8A:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dm6 50S RIBOSOMAL
PROTEIN L22

(Deinococcus
radiodurans) 		PF00237
(Ribosomal_L22) 		4 VAL P  71
LEU P  72
ILE P  45
ALA P  95
 None
 0.97A 3n8yB-5dm6P:
undetectable		 3n8yB-5dm6P:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8k GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE 10,
MITOCHONDRIAL

(Arabidopsis
thaliana) 		PF00348
(polyprenyl_synt) 		4 VAL A 294
LEU A 293
ILE A 223
ALA A 278
 None
 0.92A 3n8yB-5e8kA:
undetectable		 3n8yB-5e8kA:
19.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ejs MYOSIN-I HEAVY CHAIN

(Dictyostelium
discoideum) 		PF00373
(FERM_M)
PF00784
(MyTH4)
PF09380
(FERM_C) 		4 VAL A2222
LEU A2223
ILE A2240
ALA A2199
 None
 0.99A 3n8yB-5ejsA:
undetectable		 3n8yB-5ejsA:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 LEU A 787
TYR A 772
ILE A 725
ALA A 742
 None
 0.95A 3n8yB-5f0oA:
undetectable		 3n8yB-5f0oA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT DELTA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 VAL d 312
LEU d 286
ILE d 241
ALA d 301
 None
 0.93A 3n8yB-5gw5d:
1.1		 3n8yB-5gw5d:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hu3 CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE II ALPHA
CHAIN

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 VAL A 124
LEU A 121
ILE A 203
ALA A 199
 None
 0.88A 3n8yB-5hu3A:
undetectable		 3n8yB-5hu3A:
18.47
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		4 VAL A 349
LEU A 352
TYR A 355
ALA A 527
 ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
ID8  A 601 (-3.5A)
 0.56A 3n8yB-5ikrA:
33.4		 3n8yB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inw C-TERMINAL PEPTIDE
OF PUTATIVE
ANGIOTENSINOGEN
PUTATIVE
ANGIOTENSINOGEN

(Lampetra
fluviatilis) 		PF00079
(Serpin) 		4 LEU A 169
TYR A 301
ILE C 434
ALA A 407
 None
 0.98A 3n8yB-5inwA:
undetectable		 3n8yB-5inwA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvf SITE-DETERMINING
PROTEIN

(Pseudomonas
aeruginosa) 		PF10609
(ParA) 		4 VAL A 267
LEU A 270
ILE A  70
ALA A 113
 None
 0.95A 3n8yB-5jvfA:
undetectable		 3n8yB-5jvfA:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l1b GLUTAMATE RECEPTOR
2,GLUTAMATE RECEPTOR
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		4 VAL A 255
TYR A 250
ILE A 278
ALA A 283
 None
 0.96A 3n8yB-5l1bA:
undetectable		 3n8yB-5l1bA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 4 VAL A 182
LEU A 181
ILE A 220
ALA A 218
 None
 0.99A 3n8yB-5mqpA:
undetectable		 3n8yB-5mqpA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtv EH DOMAIN-CONTAINING
PROTEIN 4

(Mus musculus) 		PF00350
(Dynamin_N)
PF16880
(EHD_N) 		4 VAL A 235
LEU A 239
ILE A 257
ALA A 224
 None
 0.95A 3n8yB-5mtvA:
undetectable		 3n8yB-5mtvA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 VAL T1024
LEU T1027
ILE T2491
ALA T 976
 None
 0.93A 3n8yB-5ojsT:
undetectable		 3n8yB-5ojsT:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ujs UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Campylobacter
jejuni) 		PF00275
(EPSP_synthase) 		4 VAL A 263
LEU A 267
ILE A 281
ALA A 236
 None
 0.95A 3n8yB-5ujsA:
undetectable		 3n8yB-5ujsA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrf CADMIUM AND ZINC
EFFLUX PUMP FIEF

(Shewanella
oneidensis) 		no annotation 4 VAL B 166
LEU B 167
ILE B 127
ALA B 126
 None
 0.96A 3n8yB-5vrfB:
undetectable		 3n8yB-5vrfB:
9.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wel CHIMERA OF GLUTAMATE
RECEPTOR 2, GERM
CELL-SPECIFIC GENE
1-LIKE PROTEIN

(Mus musculus;
Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF07803
(GSG-1)
PF10613
(Lig_chan-Glu_bd) 		4 VAL A 255
TYR A 250
ILE A 278
ALA A 283
 None
 0.84A 3n8yB-5welA:
undetectable		 3n8yB-5welA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wug BETA-GLUCOSIDASE

(Paenibacillus
barengoltzii) 		no annotation 4 LEU A 902
TYR A 942
ILE A 949
ALA A 867
 None
 0.92A 3n8yB-5wugA:
undetectable		 3n8yB-5wugA:
8.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xex POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Staphylococcus
aureus) 		no annotation 4 LEU A  59
TYR A 107
ILE A 143
ALA A  47
 None
 1.01A 3n8yB-5xexA:
undetectable		 3n8yB-5xexA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 4 VAL A 403
LEU A 407
ILE A 422
ALA A 367
 None
 0.98A 3n8yB-6bo6A:
undetectable		 3n8yB-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6en4 SPLICING FACTOR 3B
SUBUNIT 1

(Homo sapiens) 		no annotation 4 VAL C1128
LEU C1129
ILE C1158
ALA C1117
 None
 0.95A 3n8yB-6en4C:
1.2		 3n8yB-6en4C:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 VAL A2470
LEU A2471
ILE A2502
ALA A2501
 None
 1.00A 3n8yB-6ez8A:
undetectable		 3n8yB-6ez8A:
10.63