SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8Y_B_DIFB585

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		12 VAL A 344
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
ILE A 523
GLY A 526
ALA A 527
LEU A 531
LEU A 534
 None
SCL  A 700 ( 4.6A)
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-4.3A)
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
OAS  A 530 ( 3.3A)
 0.46A 3n8yB-1ebvA:
61.4		 3n8yB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.92A 3n8yB-1hsjA:
1.9		 3n8yB-1hsjA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		5 VAL A 249
VAL A 247
LEU A 246
GLY A 279
ALA A 278
 None
 0.93A 3n8yB-1ituA:
0.0		 3n8yB-1ituA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k27 5'-DEOXY-5'-METHYLTH
IOADENOSINE
PHOSPHORYLASE

(Homo sapiens) 		PF01048
(PNP_UDP_1) 		5 VAL A 108
ILE A 114
GLY A 190
ALA A 191
LEU A  98
 None
 1.09A 3n8yB-1k27A:
0.0		 3n8yB-1k27A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mg1 PROTEIN (HTLV-1 GP21
ECTODOMAIN/MALTOSE-B
INDING PROTEIN
CHIMERA)

(Primate
T-lymphotropic
virus 1) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.01A 3n8yB-1mg1A:
0.0		 3n8yB-1mg1A:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0k GENE PRODUCT PA4716

(Pseudomonas
aeruginosa) 		PF02567
(PhzC-PhzF) 		5 ILE A  48
GLY A  79
ALA A  80
LEU A  84
LEU A  87
 None
 0.85A 3n8yB-1u0kA:
0.0		 3n8yB-1u0kA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y4c MALTOSE BINDING
PROTEIN FUSED WITH
DESIGNED HELICAL
PROTEIN

(Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.96A 3n8yB-1y4cA:
0.0		 3n8yB-1y4cA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7p HYPOTHETICAL PROTEIN
AF1403

(Archaeoglobus
fulgidus) 		PF01842
(ACT) 		5 LEU A 147
ILE A  90
GLY A  92
ALA A 150
LEU A 175
 None
 1.04A 3n8yB-1y7pA:
undetectable		 3n8yB-1y7pA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0j HYPOTHETICAL PROTEIN
SMU.848

(Streptococcus
mutans) 		PF04327
(Peptidase_Prp) 		5 VAL A  32
VAL A  36
LEU A  39
SER A  40
ALA A   4
 None
 1.07A 3n8yB-2g0jA:
undetectable		 3n8yB-2g0jA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2juo GA-BINDING PROTEIN
ALPHA CHAIN

(Mus musculus) 		PF11620
(GABP-alpha) 		5 VAL A  38
VAL A  96
LEU A  94
ILE A  48
LEU A  59
 None
 1.06A 3n8yB-2juoA:
undetectable		 3n8yB-2juoA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odr PHOSPHOSERYL-TRNA
SYNTHETASE

(Methanococcus
maripaludis) 		PF01409
(tRNA-synt_2d) 		5 VAL B 295
SER B 231
ILE B 211
LEU B 253
LEU B 254
 None
 1.02A 3n8yB-2odrB:
undetectable		 3n8yB-2odrB:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qiw PEP PHOSPHONOMUTASE

(Corynebacterium
glutamicum) 		PF13714
(PEP_mutase) 		5 VAL A  26
ILE A 101
GLY A 105
ALA A 106
LEU A  43
 None
 1.08A 3n8yB-2qiwA:
undetectable		 3n8yB-2qiwA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgw ASPARTATE
CARBAMOYLTRANSFERASE

(Methanocaldococcus
jannaschii) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 VAL A 166
VAL A 170
LEU A 173
ILE A 204
LEU A 160
 None
 0.94A 3n8yB-2rgwA:
undetectable		 3n8yB-2rgwA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-2vgqA:
undetectable		 3n8yB-2vgqA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x98 ALKALINE PHOSPHATASE

(Halobacterium
salinarum) 		PF00245
(Alk_phosphatase) 		5 VAL A 277
VAL A 281
LEU A 284
SER A 285
LEU A 328
 None
 0.83A 3n8yB-2x98A:
undetectable		 3n8yB-2x98A:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 VAL A 222
LEU A 186
GLY A 213
ALA A 214
LEU A 387
 None
 1.02A 3n8yB-2xz3A:
undetectable		 3n8yB-2xz3A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		5 SER A 727
ILE A 746
GLY A 749
ALA A 750
LEU A 760
 None
 1.06A 3n8yB-2yocA:
undetectable		 3n8yB-2yocA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-3csgA:
undetectable		 3n8yB-3csgA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Arabidopsis
thaliana;
Escherichia
coli) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.01A 3n8yB-3dm0A:
undetectable		 3n8yB-3dm0A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 VAL A-153
LEU A-189
GLY A-162
ALA A-161
LEU A  12
 None
 0.99A 3n8yB-3ehsA:
undetectable		 3n8yB-3ehsA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.99A 3n8yB-3f5fA:
undetectable		 3n8yB-3f5fA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Dermatophagoides
pteronyssinus;
Escherichia
coli) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.02A 3n8yB-3h4zA:
undetectable		 3n8yB-3h4zA:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kzx HAD-SUPERFAMILY
HYDROLASE, SUBFAMILY
IA, VARIANT 1

(Ehrlichia
chaffeensis) 		PF13419
(HAD_2) 		5 VAL A   7
GLY A  86
ALA A  87
LEU A  91
LEU A  94
 None
 0.88A 3n8yB-3kzxA:
undetectable		 3n8yB-3kzxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 VAL A-148
LEU A-184
GLY A-157
ALA A-156
LEU A  17
 None
 0.99A 3n8yB-3l2jA:
undetectable		 3n8yB-3l2jA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 VAL A 934
LEU A 898
GLY A 925
ALA A 926
LEU A1099
 None
 0.99A 3n8yB-3mp6A:
undetectable		 3n8yB-3mp6A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n93 MALTOSE BINDING
PROTEIN-CRFR2 ALPHA

(Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 VAL A-174
LEU A-210
GLY A-183
ALA A-182
LEU A  -9
 None
 0.97A 3n8yB-3n93A:
undetectable		 3n8yB-3n93A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 VAL A-152
LEU A-188
GLY A-161
ALA A-160
LEU A  13
 None
 0.98A 3n8yB-3n94A:
undetectable		 3n8yB-3n94A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 VAL N 196
LEU N 160
GLY N 187
ALA N 188
LEU N 361
 None
 0.98A 3n8yB-3o3uN:
undetectable		 3n8yB-3o3uN:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Arachis
duranensis;
Escherichia
coli) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-3ob4A:
undetectable		 3n8yB-3ob4A:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 VAL A 444
LEU A 160
GLY A 435
ALA A 436
LEU A 609
 None
 0.99A 3n8yB-3osqA:
undetectable		 3n8yB-3osqA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Escherichia
coli) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 610
 None
 0.97A 3n8yB-3osrA:
undetectable		 3n8yB-3osrA:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Deltapapillomavirus
4;
Escherichia
coli;
Homo sapiens) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.97A 3n8yB-3py7A:
undetectable		 3n8yB-3py7A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qye TBC1 DOMAIN FAMILY
MEMBER 1

(Homo sapiens) 		PF00566
(RabGAP-TBC) 		5 TYR A 889
GLY A 898
ALA A 897
LEU A 913
LEU A 916
 None
 0.97A 3n8yB-3qyeA:
undetectable		 3n8yB-3qyeA:
19.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r5g CYAB

(Pseudomonas
aeruginosa) 		PF00211
(Guanylate_cyc) 		5 LEU A 228
TYR A 336
GLY A 291
ALA A 292
LEU A 381
 None
 1.06A 3n8yB-3r5gA:
undetectable		 3n8yB-3r5gA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		5 VAL A  11
LEU A   8
ILE A  88
LEU A  22
LEU A  19
 None
None
COA  A 201 (-4.2A)
None
None
 0.78A 3n8yB-3tfyA:
undetectable		 3n8yB-3tfyA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tgl TRIACYL-GLYCEROL
ACYLHYDROLASE

(Rhizomucor
miehei) 		PF01764
(Lipase_3) 		5 VAL A 188
GLY A 147
ALA A 148
LEU A 152
LEU A 155
 None
 0.78A 3n8yB-3tglA:
0.1		 3n8yB-3tglA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vd8 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
INTERFERON-INDUCIBLE
PROTEIN AIM2

(Escherichia
coli;
Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-3vd8A:
undetectable		 3n8yB-3vd8A:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a01 PROTON
PYROPHOSPHATASE

(Vigna radiata) 		PF03030
(H_PPase) 		5 ILE A 643
GLY A 646
ALA A 647
LEU A 651
LEU A 654
 DMU  A1776 ( 4.9A)
None
DMU  A1776 ( 4.1A)
DMU  A1775 ( 4.9A)
None
 0.73A 3n8yB-4a01A:
undetectable		 3n8yB-4a01A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		5 VAL A 157
LEU A  58
GLY A  61
LEU A 128
LEU A 159
 None
None
SAM  A1474 (-3.2A)
SAM  A1474 (-4.3A)
None
 0.85A 3n8yB-4azvA:
undetectable		 3n8yB-4azvA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bla MALTOSE-BINDING
PERIPLASMIC PROTEIN,
SUPPRESSOR OF FUSED
HOMOLOG

(Escherichia
coli;
Homo sapiens) 		PF05076
(SUFU)
PF12470
(SUFU_C)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4blaA:
undetectable		 3n8yB-4blaA:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 TYR A  70
GLY A  20
ALA A  21
LEU A  25
LEU A  28
 None
 1.01A 3n8yB-4dshA:
undetectable		 3n8yB-4dshA:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4edqA:
undetectable		 3n8yB-4edqA:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		6 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
LEU A 100
 None
 0.66A 3n8yB-4eelA:
undetectable		 3n8yB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 VAL A   9
ILE A  90
ALA A  93
LEU A  97
LEU A 100
 None
 0.87A 3n8yB-4eelA:
undetectable		 3n8yB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-4egcA:
undetectable		 3n8yB-4egcA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4el8 GLYCOSIDE HYDROLASE
FAMILY 48

(Caldicellulosiruptor
bescii) 		PF02011
(Glyco_hydro_48) 		5 VAL A 450
VAL A 446
GLY A 520
ALA A 521
LEU A 528
 None
 1.09A 3n8yB-4el8A:
undetectable		 3n8yB-4el8A:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-4exkA:
undetectable		 3n8yB-4exkA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4giz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UBIQUITIN LIGASE
EA6P: CHIMERIC
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF01547
(SBP_bac_1) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.02A 3n8yB-4gizA:
undetectable		 3n8yB-4gizA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gvf BETA-HEXOSAMINIDASE

(Salmonella
enterica) 		PF00933
(Glyco_hydro_3) 		5 VAL A   4
VAL A 278
LEU A 250
SER A 251
LEU A 289
 None
 1.08A 3n8yB-4gvfA:
undetectable		 3n8yB-4gvfA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Candida
albicans;
Escherichia
coli) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 VAL A-174
LEU A-210
GLY A-183
ALA A-182
LEU A  -9
 None
 0.98A 3n8yB-4h1gA:
undetectable		 3n8yB-4h1gA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4ifpA:
undetectable		 3n8yB-4ifpA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikm MALTOSE-BINDING
PERIPLASMIC PROTEIN,
CASPASE RECRUITMENT
DOMAIN-CONTAINING
PROTEIN 8

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-4ikmA:
undetectable		 3n8yB-4ikmA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4im7 HYPOTHETICAL
OXIDOREDUCTASE YDFI

(Escherichia
coli) 		PF01232
(Mannitol_dh)
PF08125
(Mannitol_dh_C) 		5 VAL A 441
LEU A 444
GLY A 402
ALA A 401
LEU A 473
 None
 1.10A 3n8yB-4im7A:
undetectable		 3n8yB-4im7A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqe CARBOXYVINYL-CARBOXY
PHOSPHONATE
PHOSPHORYLMUTASE

(Bacillus
anthracis) 		PF13714
(PEP_mutase) 		5 VAL A  74
SER A  60
GLY A  32
ALA A  33
LEU A  81
 None
 0.98A 3n8yB-4iqeA:
undetectable		 3n8yB-4iqeA:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-4irlA:
1.1		 3n8yB-4irlA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbe GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Saccharomonospora
viridis) 		PF00171
(Aldedh) 		5 VAL A 133
ILE A 175
ALA A  34
LEU A  35
LEU A  87
 VAL  A 133 ( 0.6A)
ILE  A 175 ( 0.7A)
ALA  A  34 ( 0.0A)
LEU  A  35 ( 0.5A)
LEU  A  87 ( 0.6A)
 0.76A 3n8yB-4jbeA:
undetectable		 3n8yB-4jbeA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.01A 3n8yB-4kv3A:
undetectable		 3n8yB-4kv3A:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4log MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN
AND NR2E3 PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Homo sapiens) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 VAL A 198
LEU A 162
GLY A 189
ALA A 190
LEU A 363
 None
 1.08A 3n8yB-4logA:
undetectable		 3n8yB-4logA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m0m PUTATIVE
UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 5 VAL A 373
LEU A 380
SER A 381
ALA A 394
LEU A 408
 None
 0.85A 3n8yB-4m0mA:
undetectable		 3n8yB-4m0mA:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nuf MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
NUCLEAR RECEPTOR
SUBFAMILY 0 GROUP B
MEMBER 2 CHIMERIC
CONSTRUCT

(Escherichia
coli;
Mus musculus) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 VAL A 198
LEU A 162
GLY A 189
ALA A 190
LEU A 363
 None
 1.03A 3n8yB-4nufA:
undetectable		 3n8yB-4nufA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.96A 3n8yB-4o2xA:
undetectable		 3n8yB-4o2xA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4our PHYTOCHROME B

(Arabidopsis
thaliana) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		5 VAL B 260
VAL B 264
LEU B 267
TYR B 270
ILE B 410
 None
 1.06A 3n8yB-4ourB:
undetectable		 3n8yB-4ourB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozd 14.4 KDA SALIVARY
PROTEIN

(Phlebotomus
duboscqi) 		PF01395
(PBP_GOBP) 		5 VAL A  67
VAL A  98
TYR A  95
GLY A 105
LEU A  50
 None
 1.04A 3n8yB-4ozdA:
undetectable		 3n8yB-4ozdA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 VAL A-174
LEU A-210
GLY A-183
ALA A-182
LEU A  -9
 None
 0.99A 3n8yB-4ozqA:
undetectable		 3n8yB-4ozqA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.01A 3n8yB-4pe2A:
undetectable		 3n8yB-4pe2A:
21.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 345
VAL A 350
LEU A 353
SER A 354
TYR A 356
TYR A 386
TRP A 388
GLY A 527
ALA A 528
LEU A 532
LEU A 535
 None
IBP  A 601 (-4.3A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-4.5A)
IBP  A 601 (-4.8A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 4.9A)
EDO  A 616 ( 4.4A)
 0.47A 3n8yB-4ph9A:
32.9		 3n8yB-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		5 VAL A-175
LEU A-211
GLY A-184
ALA A-183
LEU A -10
 None
 0.99A 3n8yB-4qszA:
undetectable		 3n8yB-4qszA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-4qvhA:
undetectable		 3n8yB-4qvhA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyr AT-LESS POLYKETIDE
SYNTHASE

(Streptomyces
platensis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 VAL A2778
ILE A2549
GLY A2551
ALA A2552
LEU A2562
 None
 0.99A 3n8yB-4qyrA:
undetectable		 3n8yB-4qyrA:
21.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r0y MALTOSE-BINDING
PERIPLASMIC PROTEIN,
DISKS
LARGE-ASSOCIATED
PROTEIN 1

(Escherichia
coli;
Rattus
norvegicus) 		PF03359
(GKAP)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.95A 3n8yB-4r0yA:
undetectable		 3n8yB-4r0yA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rqo L-SERINE DEHYDRATASE

(Legionella
pneumophila) 		PF03313
(SDH_alpha)
PF03315
(SDH_beta) 		5 VAL A  46
ILE A  67
ALA A  27
LEU A  31
LEU A  34
 None
 0.76A 3n8yB-4rqoA:
undetectable		 3n8yB-4rqoA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 VAL A 198
LEU A 162
GLY A 189
ALA A 190
LEU A 363
 None
 1.00A 3n8yB-4rwfA:
undetectable		 3n8yB-4rwfA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Clostridioides
difficile;
Escherichia
coli) 		PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-4tsmA:
undetectable		 3n8yB-4tsmA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wvi MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SIGNAL
PEPTIDASE IB

(Escherichia
coli;
Staphylococcus
aureus) 		PF00717
(Peptidase_S24)
PF13416
(SBP_bac_8) 		5 VAL A 202
LEU A 166
GLY A 193
ALA A 194
LEU A 367
 None
 1.00A 3n8yB-4wviA:
undetectable		 3n8yB-4wviA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 EDO  A1202 ( 4.5A)
None
None
None
None
 1.00A 3n8yB-4xa2A:
0.0		 3n8yB-4xa2A:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zpq MCG133388, ISOFORM
CRA_F

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		5 VAL A   6
VAL A  92
LEU A  75
GLY A  43
LEU A  55
 None
 1.01A 3n8yB-4zpqA:
undetectable		 3n8yB-4zpqA:
19.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zrs ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 VAL A  72
VAL A  70
LEU A  69
GLY A 176
LEU A 124
 None
 1.09A 3n8yB-4zrsA:
undetectable		 3n8yB-4zrsA:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.98A 3n8yB-5c7rA:
undetectable		 3n8yB-5c7rA:
20.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.01A 3n8yB-5dfmA:
undetectable		 3n8yB-5dfmA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5edu MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HISTONE DEACETYLASE
6 CHIMERA

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL B 304
LEU B 268
GLY B 295
ALA B 296
LEU B 469
 None
 1.00A 3n8yB-5eduB:
undetectable		 3n8yB-5eduB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.98A 3n8yB-5gpqA:
undetectable		 3n8yB-5gpqA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1

(Homo sapiens) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 VAL A 217
VAL A 215
LEU A 214
SER A 213
GLY A 274
 None
 1.04A 3n8yB-5gtmA:
0.0		 3n8yB-5gtmA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.02A 3n8yB-5h7nA:
undetectable		 3n8yB-5h7nA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 1.00A 3n8yB-5hz7A:
undetectable		 3n8yB-5hz7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 VAL A 563
LEU A 527
GLY A 554
ALA A 555
LEU A 728
 None
 0.98A 3n8yB-5hzvA:
undetectable		 3n8yB-5hzvA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 VAL A3863
LEU A3827
GLY A3854
ALA A3855
LEU A4028
 PGE  A4205 ( 4.7A)
None
None
None
None
 1.01A 3n8yB-5ii5A:
undetectable		 3n8yB-5ii5A:
21.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 VAL A 344
VAL A 349
LEU A 352
SER A 353
TYR A 355
TYR A 385
TRP A 387
GLY A 526
ALA A 527
LEU A 531
LEU A 534
 None
ID8  A 601 (-3.9A)
ID8  A 601 (-4.1A)
ID8  A 601 ( 4.7A)
ID8  A 601 (-3.8A)
ID8  A 601 ( 3.5A)
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
None
 0.48A 3n8yB-5ikrA:
33.4		 3n8yB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		5 VAL A-173
LEU A-209
GLY A-182
ALA A-181
LEU A  -8
 None
 1.00A 3n8yB-5jonA:
undetectable		 3n8yB-5jonA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqe SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,CASPASE-8
CHIMERA

(Escherichia
coli) 		PF01335
(DED)
PF13416
(SBP_bac_8) 		5 VAL A 208
LEU A 172
GLY A 199
ALA A 200
LEU A 373
 None
 0.99A 3n8yB-5jqeA:
undetectable		 3n8yB-5jqeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 VAL A1196
LEU A 160
GLY A1187
ALA A1188
LEU A1361
 None
 0.97A 3n8yB-5k94A:
undetectable		 3n8yB-5k94A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mul NEURAMINIDASE

(Bacteroides
thetaiotaomicron) 		PF15892
(BNR_4) 		5 VAL A  46
LEU A  45
SER A  44
GLY A  66
LEU A 103
 None
 1.04A 3n8yB-5mulA:
undetectable		 3n8yB-5mulA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-5osqA:
undetectable		 3n8yB-5osqA:
20.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Danio rerio;
Escherichia
coli) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.97A 3n8yB-5t03A:
undetectable		 3n8yB-5t03A:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 1.00A 3n8yB-5tj2A:
undetectable		 3n8yB-5tj2A:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 VAL A 202
LEU A 166
GLY A 193
ALA A 194
LEU A 367
 None
 1.01A 3n8yB-5ttdA:
undetectable		 3n8yB-5ttdA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wbf METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER (TLPC)

(Helicobacter
pylori) 		no annotation 5 VAL A 103
ILE A  63
GLY A  66
ALA A  67
LEU A  74
 None
 0.82A 3n8yB-5wbfA:
undetectable		 3n8yB-5wbfA:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 VAL A 197
LEU A 161
GLY A 188
ALA A 189
LEU A 362
 None
 0.99A 3n8yB-5wq6A:
0.0		 3n8yB-5wq6A:
20.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wqn PROBABLE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00106
(adh_short) 		5 VAL A  28
GLY A  49
ALA A  48
LEU A  44
LEU A  41
 None
 1.06A 3n8yB-5wqnA:
undetectable		 3n8yB-5wqnA:
17.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6anv ANTI-CRISPR PROTEIN
ACRF1 FUSED WITH
C-TERMINAL MBP TAG

(Escherichia
coli;
Pseudomonas
phage JBD30) 		no annotation 5 VAL A 276
LEU A 240
GLY A 267
ALA A 268
LEU A 441
 None
 0.99A 3n8yB-6anvA:
undetectable		 3n8yB-6anvA:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 VAL A 196
LEU A 160
GLY A 187
ALA A 188
LEU A 361
 None
 0.97A 3n8yB-6apxA:
undetectable		 3n8yB-6apxA:
19.86