SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8X_B_NIMB1701_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bfo | CAMPATH-1G ANTIBODY (Rattus rattus) |
PF07654(C1-set)PF07686(V-set) | 3 | VAL B 199VAL B 171SER B 169 | None | 0.63A | 3n8xB-1bfoB:0.0 | 3n8xB-1bfoB:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1csj | HEPATITIS C VIRUSRNA POLYMERASE(NS5B) (Hepacivirus C) |
PF00998(RdRP_3) | 3 | VAL A 52VAL A 161SER A 282 | None | 0.69A | 3n8xB-1csjA:0.0 | 3n8xB-1csjA:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1dci | DIENOYL-COAISOMERASE (Rattusnorvegicus) |
PF00378(ECH_1) | 3 | VAL A 221VAL A 175SER A 179 | None | 0.59A | 3n8xB-1dciA:0.0 | 3n8xB-1dciA:18.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1e12 | HALORHODOPSIN (Halobacteriumsalinarum) |
PF01036(Bac_rhodopsin) | 3 | VAL A 86VAL A 227SER A 231 | None | 0.74A | 3n8xB-1e12A:0.0 | 3n8xB-1e12A:17.06 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1ebv | PROSTAGLANDIN H2SYNTHASE (Ovis aries) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | VAL A 116VAL A 349SER A 353 | NoneSCL A 700 ( 4.6A)None | 0.28A | 3n8xB-1ebvA:61.5 | 3n8xB-1ebvA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1g38 | MODIFICATIONMETHYLASE TAQI (Thermusaquaticus) |
PF07669(Eco57I)PF12950(TaqI_C) | 3 | VAL A 170VAL A 204SER A 202 | None | 0.68A | 3n8xB-1g38A:0.0 | 3n8xB-1g38A:23.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 3 | VAL A 431VAL A 86SER A 84 | None | 0.74A | 3n8xB-1gjuA:0.0 | 3n8xB-1gjuA:22.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1i5a | CHEMOTAXIS PROTEINCHEA (Thermotogamaritima) |
PF02518(HATPase_c) | 3 | VAL A 514VAL A 533SER A 522 | None | 0.72A | 3n8xB-1i5aA:undetectable | 3n8xB-1i5aA:15.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sxj | ACTIVATOR 1 40 KDASUBUNIT (Saccharomycescerevisiae) |
PF13177(DNA_pol3_delta2) | 3 | VAL E 116VAL E 87SER E 89 | None | 0.75A | 3n8xB-1sxjE:2.3 | 3n8xB-1sxjE:21.10 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tul | TLP20 (Autographacalifornicamultiplenucleopolyhedrovirus) |
PF06088(TLP-20) | 3 | VAL A 76VAL A 47SER A 49 | None | 0.72A | 3n8xB-1tulA:undetectable | 3n8xB-1tulA:11.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vl1 | 6-PHOSPHOGLUCONOLACTONASE (Thermotogamaritima) |
PF01182(Glucosamine_iso) | 3 | VAL A 208VAL A 38SER A 67 | None | 0.72A | 3n8xB-1vl1A:undetectable | 3n8xB-1vl1A:16.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1xgy | K42-41L FAB HEAVYCHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | VAL H 193VAL H 163SER H 161 | None | 0.64A | 3n8xB-1xgyH:undetectable | 3n8xB-1xgyH:14.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y12 | HYPOTHETICAL PROTEINPA0085 (Pseudomonasaeruginosa) |
PF05638(T6SS_HCP) | 3 | VAL A 107VAL A 12SER A 65 | None | 0.73A | 3n8xB-1y12A:undetectable | 3n8xB-1y12A:13.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1y25 | PROBABLE THIOLPEROXIDASE (Mycobacteriumtuberculosis) |
PF08534(Redoxin) | 3 | VAL A 147VAL A 59SER A 63 | NoneACT A1200 (-3.7A)None | 0.57A | 3n8xB-1y25A:undetectable | 3n8xB-1y25A:16.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z26 | ARGONAUTE (Pyrococcusfuriosus) |
PF02171(Piwi)PF12212(PAZ_siRNAbind) | 3 | VAL A 459VAL A 500SER A 502 | None | 0.72A | 3n8xB-1z26A:undetectable | 3n8xB-1z26A:20.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1z3i | SIMILAR TORAD54-LIKE (Danio rerio) |
PF00176(SNF2_N)PF00271(Helicase_C) | 3 | VAL X 725VAL X 494SER X 717 | None | 0.68A | 3n8xB-1z3iX:undetectable | 3n8xB-1z3iX:21.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1zq9 | PROBABLEDIMETHYLADENOSINETRANSFERASE (Homo sapiens) |
PF00398(RrnaAD) | 3 | VAL A 232VAL A 247SER A 244 | None | 0.73A | 3n8xB-1zq9A:undetectable | 3n8xB-1zq9A:17.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ztv | HYPOTHETICAL PROTEIN (Enterococcusfaecalis) |
PF01904(DUF72) | 3 | VAL A 62VAL A 165SER A 163 | None | 0.66A | 3n8xB-1ztvA:undetectable | 3n8xB-1ztvA:19.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ae0 | MEMBRANE-BOUND LYTICMUREINTRANSGLYCOSYLASE A (Escherichiacoli) |
PF03562(MltA)PF06725(3D) | 3 | VAL X 332VAL X 258SER X 260 | EDO X1439 ( 4.5A)NoneNone | 0.74A | 3n8xB-2ae0X:undetectable | 3n8xB-2ae0X:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0t | NADP ISOCITRATEDEHYDROGENASE (Corynebacteriumglutamicum) |
PF03971(IDH) | 3 | VAL A 381VAL A 403SER A 536 | None | 0.70A | 3n8xB-2b0tA:undetectable | 3n8xB-2b0tA:21.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dt8 | DEGV FAMILY PROTEIN (Thermusthermophilus) |
PF02645(DegV) | 3 | VAL A 122VAL A 96SER A 93 | NoneNonePLM A 701 (-2.5A) | 0.71A | 3n8xB-2dt8A:undetectable | 3n8xB-2dt8A:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fjk | FRUCTOSE-BISPHOSPHATE ALDOLASE (Thermuscaldophilus) |
PF01116(F_bP_aldolase) | 3 | VAL A 73VAL A 19SER A 301 | None | 0.58A | 3n8xB-2fjkA:undetectable | 3n8xB-2fjkA:18.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2hpi | DNA POLYMERASE IIIALPHA SUBUNIT (Thermusaquaticus) |
PF02811(PHP)PF07733(DNA_pol3_alpha)PF14579(HHH_6) | 3 | VAL A 679VAL A 667SER A 825 | None | 0.74A | 3n8xB-2hpiA:undetectable | 3n8xB-2hpiA:18.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3h | NADP-DEPENDENTOXIDOREDUCTASE P1 (Arabidopsisthaliana) |
PF00107(ADH_zinc_N)PF16884(ADH_N_2) | 3 | VAL A 342VAL A 104SER A 110 | None | 0.68A | 3n8xB-2j3hA:undetectable | 3n8xB-2j3hA:22.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2j3s | FILAMIN-A (Homo sapiens) |
PF00630(Filamin) | 3 | VAL A2134VAL A2090SER A2088 | None | 0.63A | 3n8xB-2j3sA:undetectable | 3n8xB-2j3sA:19.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2nas | UNCHARACTERIZEDPROTEIN (Trypanosomabrucei) |
PF00855(PWWP) | 3 | VAL A 11VAL A 42SER A 4 | None | 0.75A | 3n8xB-2nasA:undetectable | 3n8xB-2nasA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o69 | IRON-UTILIZATIONPERIPLASMIC PROTEIN (Haemophilusinfluenzae) |
PF01547(SBP_bac_1) | 3 | VAL A 104VAL A 182SER A 211 | None | 0.74A | 3n8xB-2o69A:undetectable | 3n8xB-2o69A:19.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2p88 | MANDELATERACEMASE/MUCONATELACTONIZING ENZYMEFAMILY PROTEIN (Bacillus cereus) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 3 | VAL A 136VAL A 297SER A 295 | None | 0.75A | 3n8xB-2p88A:undetectable | 3n8xB-2p88A:20.46 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y5w | KINESIN HEAVY CHAIN (Drosophilamelanogaster) |
PF00225(Kinesin) | 3 | VAL A 58VAL A 35SER A 47 | None | 0.69A | 3n8xB-2y5wA:undetectable | 3n8xB-2y5wA:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y89 | PHOSPHORIBOSYLISOMERASE A (Mycobacteriumtuberculosis) |
PF00977(His_biosynth) | 3 | VAL A 52VAL A 168SER A 200 | None | 0.73A | 3n8xB-2y89A:undetectable | 3n8xB-2y89A:17.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ypd | PROBABLE JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATION PROTEIN 2C (Homo sapiens) |
PF02373(JmjC) | 3 | VAL A2477VAL A2197SER A2284 | None | 0.65A | 3n8xB-2ypdA:undetectable | 3n8xB-2ypdA:22.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2yxx | DIAMINOPIMELATEDECARBOXYLASE (Thermotogamaritima) |
PF00278(Orn_DAP_Arg_deC)PF02784(Orn_Arg_deC_N) | 3 | VAL A 66VAL A 80SER A 82 | None | 0.67A | 3n8xB-2yxxA:undetectable | 3n8xB-2yxxA:20.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3c60 | TCR YAE62 ALPHACHAIN (Mus musculus) |
PF07686(V-set)PF09291(DUF1968) | 3 | VAL A 120VAL A 145SER A 191 | None | 0.73A | 3n8xB-3c60A:undetectable | 3n8xB-3c60A:15.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3dmm | T-CELL SURFACEGLYCOPROTEIN CD8BETA CHAIN (Mus musculus) |
PF07686(V-set) | 3 | VAL D 63VAL D 57SER D 50 | None | 0.74A | 3n8xB-3dmmD:undetectable | 3n8xB-3dmmD:13.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gsz | RNA-DIRECTED RNAPOLYMERASE (Hepacivirus C) |
PF00998(RdRP_3) | 3 | VAL A 52VAL A 161SER A 282 | None | 0.60A | 3n8xB-3gszA:undetectable | 3n8xB-3gszA:22.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hps | 2-ISOPROPYLMALATESYNTHASE (Mycobacteriumtuberculosis) |
PF00682(HMGL-like)PF08502(LeuA_dimer) | 3 | VAL A 53VAL A 262SER A 266 | None | 0.45A | 3n8xB-3hpsA:undetectable | 3n8xB-3hpsA:21.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hpx | 2-ISOPROPYLMALATESYNTHASE (Mycobacteriumtuberculosis) |
PF00682(HMGL-like) | 3 | VAL A 53VAL A 262SER A 266 | None | 0.47A | 3n8xB-3hpxA:undetectable | 3n8xB-3hpxA:19.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j81 | US5 (Kluyveromyceslactis) |
PF00333(Ribosomal_S5)PF03719(Ribosomal_S5_C) | 3 | VAL C 170VAL C 189SER C 186 | C 2 14 ( 4.5A)None U 2 5 ( 3.2A) | 0.72A | 3n8xB-3j81C:undetectable | 3n8xB-3j81C:18.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3k4w | UNCHARACTERIZEDPROTEIN BB4693 (Bordetellabronchiseptica) |
PF04909(Amidohydro_2) | 3 | VAL A 94VAL A 185SER A 187 | None | 0.69A | 3n8xB-3k4wA:undetectable | 3n8xB-3k4wA:19.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3mmp | ELONGATION FACTOR TU2, ELONGATION FACTORTS (Escherichiacoli) |
PF00009(GTP_EFTU)PF00889(EF_TS)PF03143(GTP_EFTU_D3)PF03144(GTP_EFTU_D2) | 3 | VAL A 226VAL A 190SER A 186 | None | 0.67A | 3n8xB-3mmpA:undetectable | 3n8xB-3mmpA:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3nby | SNURPORTIN-1 (Homo sapiens) |
PF11538(Snurportin1) | 3 | VAL B 281VAL B 244SER B 246 | None | 0.68A | 3n8xB-3nbyB:undetectable | 3n8xB-3nbyB:20.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pw3 | AMINOPEPTIDASE C (Parabacteroidesdistasonis) |
PF03051(Peptidase_C1_2) | 3 | VAL A 359VAL A 272SER A 270 | None | 0.60A | 3n8xB-3pw3A:undetectable | 3n8xB-3pw3A:22.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q94 | FRUCTOSE-BISPHOSPHATE ALDOLASE, CLASS II (Bacillusanthracis) |
PF01116(F_bP_aldolase) | 3 | VAL A 78VAL A 20SER A 281 | None | 0.67A | 3n8xB-3q94A:undetectable | 3n8xB-3q94A:19.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r4k | TRANSCRIPTIONALREGULATOR, ICLRFAMILY (Ruegeria sp.TM1040) |
PF01614(IclR)PF09339(HTH_IclR) | 3 | VAL A 179VAL A 150SER A 145 | None | 0.74A | 3n8xB-3r4kA:undetectable | 3n8xB-3r4kA:20.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r6m | YEAZ, RESUSCITATIONPROMOTING FACTOR (Vibrioparahaemolyticus) |
PF00814(Peptidase_M22) | 3 | VAL A 46VAL A 196SER A 192 | None | 0.59A | 3n8xB-3r6mA:undetectable | 3n8xB-3r6mA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r7w | GTP-BINDING PROTEINGTR2 (Saccharomycescerevisiae) |
PF04670(Gtr1_RagA) | 3 | VAL B 179VAL B 29SER B 212 | None | 0.75A | 3n8xB-3r7wB:undetectable | 3n8xB-3r7wB:20.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rjl | 1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE (Bacilluslicheniformis) |
PF00171(Aldedh) | 3 | VAL A 232VAL A 101SER A 225 | None | 0.70A | 3n8xB-3rjlA:2.1 | 3n8xB-3rjlA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3t8l | ADENINE DEAMINASE 2 (Agrobacteriumfabrum) |
PF01979(Amidohydro_1)PF13382(Adenine_deam_C) | 3 | VAL A 109VAL A 291SER A 98 | None | 0.60A | 3n8xB-3t8lA:undetectable | 3n8xB-3t8lA:21.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ucq | AMYLOSUCRASE (Deinococcusgeothermalis) |
PF00128(Alpha-amylase) | 3 | VAL A 492VAL A 173SER A 171 | None | 0.70A | 3n8xB-3ucqA:undetectable | 3n8xB-3ucqA:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3uw3 | ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (Burkholderiathailandensis) |
PF01118(Semialdhyde_dh)PF02774(Semialdhyde_dhC) | 3 | VAL A 309VAL A 325SER A 321 | None | 0.70A | 3n8xB-3uw3A:3.3 | 3n8xB-3uw3A:21.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vr5 | V-TYPE SODIUM ATPASESUBUNIT B (Enterococcushirae) |
PF00006(ATP-synt_ab)PF02874(ATP-synt_ab_N) | 3 | VAL D 11VAL D 32SER D 68 | None | 0.67A | 3n8xB-3vr5D:undetectable | 3n8xB-3vr5D:22.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vx8 | UBIQUITIN-LIKEMODIFIER-ACTIVATINGENZYME ATG7 (Arabidopsisthaliana) |
no annotation | 3 | VAL D 185VAL D 285SER D 283 | None | 0.73A | 3n8xB-3vx8D:undetectable | 3n8xB-3vx8D:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4af2 | THIOL PEROXIDASE (Escherichiacoli) |
PF08534(Redoxin) | 3 | VAL A 150VAL A 60SER A 64 | None | 0.62A | 3n8xB-4af2A:undetectable | 3n8xB-4af2A:16.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b2o | YMDBPHOSPHODIESTERASE (Bacillussubtilis) |
PF13277(YmdB) | 3 | VAL A 9VAL A 22SER A 58 | None | 0.70A | 3n8xB-4b2oA:undetectable | 3n8xB-4b2oA:19.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4btg | MAJOR INNER PROTEINP1 (Pseudomonasvirus phi6) |
no annotation | 3 | VAL A 190VAL A 253SER A 251 | None | 0.69A | 3n8xB-4btgA:undetectable | 3n8xB-4btgA:19.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4dz4 | AGMATINASE (Burkholderiathailandensis) |
PF00491(Arginase) | 3 | VAL A 47VAL A 69SER A 73 | None | 0.71A | 3n8xB-4dz4A:undetectable | 3n8xB-4dz4A:18.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fn5 | ELONGATION FACTOR G1 (Pseudomonasaeruginosa) |
PF00009(GTP_EFTU)PF00679(EFG_C)PF03144(GTP_EFTU_D2)PF03764(EFG_IV)PF14492(EFG_II) | 3 | VAL A 673VAL A 622SER A 684 | None | 0.62A | 3n8xB-4fn5A:undetectable | 3n8xB-4fn5A:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4hds | ARSB (Sporomusa ovata) |
PF02277(DBI_PRT) | 3 | VAL B 101VAL B 247SER B 274 | EDO B 902 ( 4.4A)NoneNone | 0.71A | 3n8xB-4hdsB:undetectable | 3n8xB-4hdsB:21.38 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i99 | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusfuriosus) |
PF02463(SMC_N) | 3 | VAL A 20VAL A1149SER A 14 | None | 0.68A | 3n8xB-4i99A:3.0 | 3n8xB-4i99A:20.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9f | GLYCEROL 3-PHOSPHATEPHOSPHATASE (Mycobacteriumtuberculosis) |
PF13242(Hydrolase_like)PF13344(Hydrolase_6) | 3 | VAL A 207VAL A 36SER A 32 | None | 0.74A | 3n8xB-4i9fA:undetectable | 3n8xB-4i9fA:20.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i9u | L-LACTATEDEHYDROGENASE ACHAIN (Oryctolaguscuniculus) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 3 | VAL A 255VAL A 139SER A 136 | None | 0.75A | 3n8xB-4i9uA:undetectable | 3n8xB-4i9uA:19.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4inj | LMO1638 PROTEIN (Listeriamonocytogenes) |
PF02016(Peptidase_S66) | 3 | VAL A 29VAL A 49SER A 20 | None | 0.63A | 3n8xB-4injA:undetectable | 3n8xB-4injA:22.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4j5t | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE (Saccharomycescerevisiae) |
PF03200(Glyco_hydro_63)PF16923(Glyco_hydro_63N) | 3 | VAL A 216VAL A 123SER A 121 | None | 0.71A | 3n8xB-4j5tA:undetectable | 3n8xB-4j5tA:21.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4jy4 | PGT121 HEAVY CHAIN (Homo sapiens) |
PF07654(C1-set)PF07686(V-set) | 3 | VAL B 51VAL B 67SER B 81 | None | 0.71A | 3n8xB-4jy4B:undetectable | 3n8xB-4jy4B:16.18 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kss | TYPE II SECRETIONSYSTEM PROTEIN E,HEMOLYSIN-COREGULATED PROTEIN (Pseudomonasaeruginosa;Vibrio cholerae) |
PF00437(T2SSE)PF05638(T6SS_HCP) | 3 | VAL A 616VAL A 521SER A 574 | None | 0.74A | 3n8xB-4kssA:undetectable | 3n8xB-4kssA:21.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4lrj | EFFECTOR NLEH1 (Escherichiacoli) |
no annotation | 3 | VAL A 288VAL A 245SER A 208 | None | 0.72A | 3n8xB-4lrjA:undetectable | 3n8xB-4lrjA:14.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4nv0 | 7-METHYLGUANOSINEPHOSPHATE-SPECIFIC5'-NUCLEOTIDASE (Drosophilamelanogaster) |
PF05822(UMPH-1) | 3 | VAL A 242VAL A 256SER A 259 | None | 0.75A | 3n8xB-4nv0A:undetectable | 3n8xB-4nv0A:20.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4o48 | UNCHARACTERIZEDPROTEIN (Cavia porcellus) |
PF01112(Asparaginase_2) | 3 | VAL A 108VAL A 95SER A 93 | None | 0.72A | 3n8xB-4o48A:undetectable | 3n8xB-4o48A:18.39 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4oxi | ENTEROBACTINSYNTHETASE COMPONENTF-RELATED PROTEIN (Vibrio cholerae) |
PF00501(AMP-binding) | 3 | VAL A 440VAL A 355SER A 358 | None | 0.72A | 3n8xB-4oxiA:undetectable | 3n8xB-4oxiA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4p3z | COPN (Chlamydiapneumoniae) |
PF07201(HrpJ) | 3 | VAL A 284VAL A 329SER A 310 | NoneNoneMLZ A 313 ( 3.2A) | 0.66A | 3n8xB-4p3zA:1.4 | 3n8xB-4p3zA:21.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pc9 | C4-DICARBOXYLATETRANSPORT SYSTEM,SUBSTRATE-BINDINGPROTEIN, PUTATIVE (Roseobacterdenitrificans) |
PF03480(DctP) | 3 | VAL A 175VAL A 234SER A 236 | CS2 A 401 (-4.6A)NoneNone | 0.68A | 3n8xB-4pc9A:undetectable | 3n8xB-4pc9A:19.05 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4ph9 | PROSTAGLANDIN G/HSYNTHASE 2 (Mus musculus) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | VAL A 117VAL A 350SER A 354 | BOG A 604 (-3.9A)IBP A 601 (-4.3A)None | 0.12A | 3n8xB-4ph9A:57.9 | 3n8xB-4ph9A:64.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 3 | VAL B 868VAL B 806SER B 804 | None | 0.74A | 3n8xB-4qiwB:undetectable | 3n8xB-4qiwB:19.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qti | ANTI-UPAR ANTIBODY,HEAVY CHAIN (Mus musculus) |
PF07654(C1-set)PF07686(V-set) | 3 | VAL H 202VAL H 172SER H 170 | None | 0.73A | 3n8xB-4qtiH:undetectable | 3n8xB-4qtiH:14.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4u28 | PHOSPHORIBOSYLISOMERASE A (Streptomycessviceus) |
PF00977(His_biosynth) | 3 | VAL A 56VAL A 168SER A 200 | NoneNonePO4 A 301 ( 4.4A) | 0.73A | 3n8xB-4u28A:undetectable | 3n8xB-4u28A:16.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wvm | STONUSTOXIN SUBUNITBETA (Synanceiahorrida) |
PF00622(SPRY)PF13765(PRY) | 3 | VAL B 8VAL B 84SER B 78 | None | 0.73A | 3n8xB-4wvmB:undetectable | 3n8xB-4wvmB:21.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x2r | 1-(5-PHOSPHORIBOSYL)-5-[(5-PHOSPHORIBOSYLAMINO)METHYLIDENEAMINO]IMIDAZOLE-4-CARBOXAMIDE ISOMERASE (Actinomycesurogenitalis) |
PF00977(His_biosynth) | 3 | VAL A 50VAL A 162SER A 194 | PO4 A 303 (-4.7A)NonePO4 A 303 ( 4.2A) | 0.70A | 3n8xB-4x2rA:undetectable | 3n8xB-4x2rA:18.35 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x3m | RNA 2'-O RIBOSEMETHYLTRANSFERASE (Thermusthermophilus) |
PF00588(SpoU_methylase) | 3 | VAL A 164VAL A 151SER A 155 | None | 0.70A | 3n8xB-4x3mA:undetectable | 3n8xB-4x3mA:19.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4x9s | PHOSPHORIBOSYLISOMERASE A (Streptomycessp. Mg1) |
PF00977(His_biosynth) | 3 | VAL A 54VAL A 166SER A 198 | SO4 A 305 (-4.8A)NoneSO4 A 305 ( 4.3A) | 0.73A | 3n8xB-4x9sA:undetectable | 3n8xB-4x9sA:17.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4zpi | PUTATIVEOXIDASE/HYDROXYLASE (Streptomyceshygroscopicus) |
PF05721(PhyH) | 3 | VAL A 257VAL A 180SER A 182 | None | 0.70A | 3n8xB-4zpiA:undetectable | 3n8xB-4zpiA:19.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bp1 | MYCOCEROSIC ACIDSYNTHASE (Mycolicibacteriumsmegmatis) |
PF00109(ketoacyl-synt)PF00698(Acyl_transf_1)PF02801(Ketoacyl-synt_C)PF16197(KAsynt_C_assoc) | 3 | VAL A 737VAL A 690SER A 692 | None | 0.70A | 3n8xB-5bp1A:undetectable | 3n8xB-5bp1A:20.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dmh | UNCHARACTERIZEDPROTEIN CONSERVED INBACTERIA (Cupriavidusnecator) |
PF07005(DUF1537)PF17042(DUF1357_C) | 3 | VAL A 347VAL A 331SER A 326 | ADP A 501 (-3.8A)ADP A 501 ( 3.9A)ADP A 501 (-2.7A) | 0.70A | 3n8xB-5dmhA:undetectable | 3n8xB-5dmhA:22.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ewr | BOX C/D SNORNP ANDU4 SNRNP COMPONENTSNU13P (Cyanidioschyzonmerolae) |
PF01248(Ribosomal_L7Ae) | 3 | VAL A 116VAL A 43SER A 47 | None | 0.69A | 3n8xB-5ewrA:undetectable | 3n8xB-5ewrA:13.86 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5fzo | PROBABLE JMJCDOMAIN-CONTAININGHISTONEDEMETHYLATION PROTEIN 2C (Homo sapiens) |
PF02373(JmjC) | 3 | VAL A2477VAL A2197SER A2284 | None | 0.68A | 3n8xB-5fzoA:undetectable | 3n8xB-5fzoA:22.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5gaf | SIGNAL RECOGNITIONPARTICLE PROTEIN (Escherichiacoli) |
PF00466(Ribosomal_L10) | 3 | VAL i 208VAL i 135SER i 162 | None | 0.62A | 3n8xB-5gafi:3.0 | 3n8xB-5gafi:21.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h5b | THYMIDYLATE KINASE (Aquifexaeolicus) |
no annotation | 3 | VAL B 170VAL B 192SER B 190 | None | 0.74A | 3n8xB-5h5bB:undetectable | 3n8xB-5h5bB:17.80 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5ikr | PROSTAGLANDIN G/HSYNTHASE 2 (Homo sapiens) |
PF00008(EGF)PF03098(An_peroxidase) | 3 | VAL A 116VAL A 349SER A 353 | NoneID8 A 601 (-3.9A)ID8 A 601 ( 4.7A) | 0.19A | 3n8xB-5ikrA:58.3 | 3n8xB-5ikrA:63.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kte | DIVALENT METALCATION TRANSPORTERMNTH (Deinococcusradiodurans) |
PF01566(Nramp) | 3 | VAL A 179VAL A 330SER A 328 | None | 0.64A | 3n8xB-5kteA:undetectable | 3n8xB-5kteA:20.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lnq | 3-KETOACYL-COATHIOLASE-LIKEPROTEIN (Leishmaniamexicana) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 3 | VAL A 73VAL A 18SER A 64 | None | 0.65A | 3n8xB-5lnqA:undetectable | 3n8xB-5lnqA:21.53 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n29 | CTP SYNTHASE (Trypanosomabrucei) |
PF00117(GATase) | 3 | VAL A 424VAL A 330SER A 366 | NoneNone CL A 602 (-3.3A) | 0.72A | 3n8xB-5n29A:undetectable | 3n8xB-5n29A:17.63 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5o0j | ADP-DEPENDENTGLUCOKINASE (Pyrococcushorikoshii) |
no annotation | 3 | VAL A 190VAL A 59SER A 63 | None | 0.66A | 3n8xB-5o0jA:0.7 | 3n8xB-5o0jA:10.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uja | BOVINE MULTIDRUGRESISTANCE PROTEIN 1(MRP1),MULTIDRUGRESISTANCE-ASSOCIATED PROTEIN 1 (Bos taurus) |
PF00005(ABC_tran)PF00664(ABC_membrane) | 3 | VAL A 254VAL A1181SER A1177 | None | 0.74A | 3n8xB-5ujaA:undetectable | 3n8xB-5ujaA:16.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vhs | 26S PROTEASOMENON-ATPASEREGULATORY SUBUNIT 3 (Homo sapiens) |
PF01399(PCI)PF08375(Rpn3_C) | 3 | VAL V 438VAL V 458SER V 460 | None | 0.52A | 3n8xB-5vhsV:undetectable | 3n8xB-5vhsV:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5w7a | ACYLOXYACYLHYDROLASE LARGESUBUNITACYLOXYACYLHYDROLASE SMALLSUBUNIT (Oryctolaguscuniculus) |
no annotation | 3 | VAL B 442VAL A 44SER A 48 | None | 0.66A | 3n8xB-5w7aB:undetectable | 3n8xB-5w7aB:8.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x18 | CASEIN KINASE IHOMOLOG 1 (Saccharomycescerevisiae) |
PF00069(Pkinase) | 3 | VAL A 299VAL A 317SER A 319 | None | 0.73A | 3n8xB-5x18A:undetectable | 3n8xB-5x18A:20.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xei | CHROMOSOME PARTITIONPROTEIN SMC (Pyrococcusyayanosii) |
PF02463(SMC_N) | 3 | VAL A 20VAL A1149SER A 14 | None | 0.55A | 3n8xB-5xeiA:2.6 | 3n8xB-5xeiA:20.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xqw | FAB FRAGMENT OFCATALYTIC ANTIBODY7B9, HEAVY CHAINFAB FRAGMENT OFCATALYTIC ANTIBODY7B9, LIGHT CHAIN (Mus musculus) |
no annotation | 3 | VAL L 89VAL H 93SER H 95 | 8EU H 301 ( 4.8A)8EU H 301 ( 4.7A)8EU H 301 (-2.7A) | 0.52A | 3n8xB-5xqwL:undetectable | 3n8xB-5xqwL:10.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5yq3 | AT3G55470 (Arabidopsisthaliana) |
no annotation | 3 | VAL A 76VAL A 125SER A 123 | None | 0.64A | 3n8xB-5yq3A:undetectable | 3n8xB-5yq3A:10.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6bcq | TRANSIENT RECEPTORPOTENTIAL CATIONCHANNEL SUBFAMILY MMEMBER 4 (Mus musculus) |
no annotation | 3 | VAL B 672VAL B 586SER B 623 | None | 0.57A | 3n8xB-6bcqB:undetectable | 3n8xB-6bcqB:8.32 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6fik | POLYKETIDE SYNTHASE (Cercosporanicotianae) |
no annotation | 3 | VAL A 276VAL A 289SER A 282 | None | 0.74A | 3n8xB-6fikA:undetectable | 3n8xB-6fikA:9.63 |