SIMILAR PATTERNS OF AMINO ACIDS FOR 3N8X_B_NIMB1701_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 LEU A 325
ILE A 155
GLY A 157
ALA A 156
LEU A 309
 None
 1.05A 3n8xB-1cj2A:
0.0		 3n8xB-1cj2A:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		5 HIS A 429
TYR A 430
LEU A  37
GLY A 278
LEU A 237
 None
 1.02A 3n8xB-1dj2A:
0.0		 3n8xB-1dj2A:
21.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		11 HIS A  90
ARG A 120
LEU A 352
TYR A 355
LEU A 359
TRP A 387
PHE A 518
ILE A 523
GLY A 526
ALA A 527
LEU A 531
 None
SCL  A 700 (-3.9A)
SCL  A 700 ( 4.8A)
SCL  A 700 (-4.3A)
None
None
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
OAS  A 530 (-4.1A)
 0.40A 3n8xB-1ebvA:
61.5		 3n8xB-1ebvA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ebv PROSTAGLANDIN H2
SYNTHASE

(Ovis aries) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		6 HIS A 513
LEU A 352
TRP A 387
ILE A 523
GLY A 526
ALA A 527
 None
SCL  A 700 ( 4.8A)
None
SCL  A 700 (-3.4A)
SCL  A 700 ( 4.0A)
SCL  A 700 (-2.9A)
 1.35A 3n8xB-1ebvA:
61.5		 3n8xB-1ebvA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hyn BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 HIS P 161
LEU P 269
GLY P 130
ALA P 132
LEU P 136
 None
 0.98A 3n8xB-1hynP:
0.0		 3n8xB-1hynP:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jcf ROD
SHAPE-DETERMINING
PROTEIN MREB

(Thermotoga
maritima) 		PF06723
(MreB_Mbl) 		5 LEU A 323
ILE A  84
GLY A 122
ALA A 123
SER A 124
 None
 0.95A 3n8xB-1jcfA:
0.0		 3n8xB-1jcfA:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k0f PERIPLASMIC
ZINC-BINDING PROTEIN
TROA

(Treponema
pallidum) 		PF01297
(ZnuA) 		5 LEU A  60
LEU A  57
ILE A  86
GLY A  81
ALA A  83
 None
 1.11A 3n8xB-1k0fA:
0.0		 3n8xB-1k0fA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lki LEUKEMIA INHIBITORY
FACTOR

(Mus musculus) 		PF01291
(LIF_OSM) 		5 LEU A  94
ILE A 173
ALA A  37
SER A  36
LEU A  40
 None
 1.05A 3n8xB-1lkiA:
undetectable		 3n8xB-1lkiA:
15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mje BREAST CANCER 2

(Mus musculus) 		PF09103
(BRCA-2_OB1)
PF09104
(BRCA-2_OB3)
PF09121
(Tower)
PF09169
(BRCA-2_helical) 		5 LEU A3009
LEU A3012
GLY A3025
ALA A3058
LEU A3043
 None
 1.12A 3n8xB-1mjeA:
1.6		 3n8xB-1mjeA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofe FERREDOXIN-DEPENDENT
GLUTAMATE SYNTHASE 2

(Synechocystis
sp. PCC 6803) 		PF00310
(GATase_2)
PF01493
(GXGXG)
PF01645
(Glu_synthase)
PF04898
(Glu_syn_central) 		5 HIS A 806
LEU A 888
GLY A1151
SER A 881
LEU A 880
 None
 1.08A 3n8xB-1ofeA:
undetectable		 3n8xB-1ofeA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pzx HYPOTHETICAL PROTEIN
APC36103

(Geobacillus
stearothermophilus) 		PF02645
(DegV) 		5 LEU A  91
ILE A 263
GLY A 272
ALA A 271
LEU A 169
 PLM  A 702 ( 4.5A)
PLM  A 702 (-4.4A)
None
PLM  A 702 ( 4.7A)
None
 1.04A 3n8xB-1pzxA:
0.0		 3n8xB-1pzxA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1squ CHEX PROTEIN

(Thermotoga
maritima) 		PF13690
(CheX) 		5 LEU A  56
ILE A 113
GLY A  98
ALA A 101
LEU A 104
 None
 1.12A 3n8xB-1squA:
undetectable		 3n8xB-1squA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ta3 ENDO-1,4-BETA-XYLANA
SE

(Aspergillus
nidulans) 		PF00331
(Glyco_hydro_10) 		5 HIS B 211
GLY B 219
ALA B 220
SER B 223
LEU B 224
 None
 1.01A 3n8xB-1ta3B:
undetectable		 3n8xB-1ta3B:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wa5 IMPORTIN ALPHA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		5 LEU B 456
PHE B 509
ILE B 486
GLY B 482
LEU B 433
 None
 0.99A 3n8xB-1wa5B:
undetectable		 3n8xB-1wa5B:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7x MAJOR VAULT PROTEIN

(Homo sapiens) 		PF01505
(Vault) 		5 LEU A  66
LEU A  36
ILE A  59
GLY A  94
ALA A  95
 None
 1.03A 3n8xB-1y7xA:
undetectable		 3n8xB-1y7xA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dph FORMALDEHYDE
DISMUTASE

(Pseudomonas
putida) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 236
GLY A 280
ALA A 281
SER A 284
LEU A 285
 NAD  A1403 (-4.7A)
NAD  A1403 ( 4.4A)
NAD  A1403 ( 4.0A)
None
None
 1.06A 3n8xB-2dphA:
undetectable		 3n8xB-2dphA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 LEU A 521
PHE A 257
ILE A 394
GLY A 216
ALA A 217
 None
 1.08A 3n8xB-2fjaA:
undetectable		 3n8xB-2fjaA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hy5 INTRACELLULAR SULFUR
OXIDATION PROTEIN
DSRF

(Allochromatium
vinosum) 		PF02635
(DrsE) 		5 LEU B 242
LEU B 251
ILE B 318
SER B 286
LEU B 287
 None
 1.08A 3n8xB-2hy5B:
undetectable		 3n8xB-2hy5B:
14.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o6w REPEAT FIVE RESIDUE
(RFR) PROTEIN OR
PENTAPEPTIDE REPEAT
PROTEIN

(Cyanothece) 		PF00805
(Pentapeptide) 		5 LEU A 137
ILE A 151
GLY A 149
ALA A 150
LEU A 127
 None
 1.07A 3n8xB-2o6wA:
undetectable		 3n8xB-2o6wA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pvq GLUTATHIONE
S-TRANSFERASE

(Ochrobactrum
anthropi) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 LEU A 132
LEU A 139
PHE A 108
ILE A 161
GLY A 163
 None
 0.86A 3n8xB-2pvqA:
undetectable		 3n8xB-2pvqA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpq ACETYL-COA
CARBOXYLASE

(Staphylococcus
aureus) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		6 ARG A 405
LEU A 426
PHE A 337
ILE A 391
ALA A 406
SER A 408
 None
 1.37A 3n8xB-2vpqA:
undetectable		 3n8xB-2vpqA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdf PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Escherichia
coli) 		PF00391
(PEP-utilizers)
PF02896
(PEP-utilizers_C)
PF05524
(PEP-utilisers_N) 		5 HIS A 189
LEU A 173
ILE A 192
ALA A 194
LEU A 199
 None
 1.10A 3n8xB-2xdfA:
undetectable		 3n8xB-2xdfA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yev CYTOCHROME C OXIDASE
SUBUNIT 2

(Thermus
thermophilus) 		PF00034
(Cytochrom_C)
PF00116
(COX2)
PF02790
(COX2_TM) 		5 LEU B 145
ILE B 183
GLY B 171
ALA B 170
LEU B 169
 None
 1.08A 3n8xB-2yevB:
undetectable		 3n8xB-2yevB:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yg8 DNA-3-METHYLADENINE
GLYCOSIDASE II,
PUTATIVE

(Deinococcus
radiodurans) 		PF00730
(HhH-GPD) 		5 LEU A  65
LEU A  98
GLY A  71
ALA A  70
LEU A 111
 None
 1.07A 3n8xB-2yg8A:
undetectable		 3n8xB-2yg8A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yyl 4-HYDROXYPHENYLACETA
TE-3-HYDROXYLASE

(Thermus
thermophilus) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		5 LEU A 418
LEU A 387
ILE A 310
GLY A 407
LEU A 405
 None
 1.10A 3n8xB-2yylA:
0.6		 3n8xB-2yylA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axi OLIGO-1,6-GLUCOSIDAS
E IMA1

(Saccharomyces
cerevisiae) 		PF00128
(Alpha-amylase) 		5 TRP A 451
PHE A  28
ILE A  42
GLY A  41
ALA A  43
 None
 1.12A 3n8xB-3axiA:
undetectable		 3n8xB-3axiA:
19.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bwx ALPHA/BETA HYDROLASE

(Novosphingobium
aromaticivorans) 		PF12697
(Abhydrolase_6) 		5 LEU A 113
PHE A  98
ILE A 121
ALA A 124
LEU A 126
 None
 1.12A 3n8xB-3bwxA:
undetectable		 3n8xB-3bwxA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3crw XPD/RAD3 RELATED DNA
HELICASE

(Sulfolobus
acidocaldarius) 		PF06733
(DEAD_2)
PF13307
(Helicase_C_2) 		5 LEU 1 308
PHE 1 160
ILE 1 179
ALA 1 182
LEU 1 325
 None
 1.03A 3n8xB-3crw1:
undetectable		 3n8xB-3crw1:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 210
LEU X 167
GLY X 187
ALA X 188
LEU X 157
 None
 1.10A 3n8xB-3du1X:
undetectable		 3n8xB-3du1X:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3du1 ALL3740 PROTEIN

(Nostoc sp. PCC
7120) 		PF00805
(Pentapeptide) 		5 LEU X 225
ILE X 219
GLY X 217
ALA X 218
LEU X 215
 None
 1.11A 3n8xB-3du1X:
undetectable		 3n8xB-3du1X:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 LEU A  62
ILE A 124
GLY A 120
ALA A  92
SER A  93
 None
 1.11A 3n8xB-3gczA:
undetectable		 3n8xB-3gczA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcz POLYPROTEIN

(Yokose virus) 		PF01728
(FtsJ) 		5 LEU A  62
ILE A 124
GLY A 120
SER A  93
LEU A  94
 None
 1.08A 3n8xB-3gczA:
undetectable		 3n8xB-3gczA:
19.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gi8 UNCHARACTERIZED
PROTEIN MJ0609

(Methanocaldococcus
jannaschii) 		PF13520
(AA_permease_2) 		5 LEU C 162
ILE C 276
GLY C 279
ALA C 280
SER C 283
 None
 1.00A 3n8xB-3gi8C:
undetectable		 3n8xB-3gi8C:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hz6 XYLULOKINASE

(Chromobacterium
violaceum) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ILE A 307
GLY A 384
ALA A 385
SER A 388
LEU A 389
 None
 1.00A 3n8xB-3hz6A:
undetectable		 3n8xB-3hz6A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca PROTEIN DOM34

(Schizosaccharomyces
pombe) 		PF03463
(eRF1_1)
PF03464
(eRF1_2)
PF03465
(eRF1_3) 		5 HIS B 350
LEU B 266
ILE B 152
GLY B 138
ALA B 139
 None
 1.02A 3n8xB-3mcaB:
undetectable		 3n8xB-3mcaB:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mwc MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Kosmotoga
olearia) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 174
PHE A 205
ILE A 181
GLY A 152
ALA A 153
 None
 1.09A 3n8xB-3mwcA:
undetectable		 3n8xB-3mwcA:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndy ENDOGLUCANASE D

(Clostridium
cellulovorans) 		PF00553
(CBM_2) 		5 TYR E 387
ILE E 465
GLY E 396
ALA E 397
SER E 392
 None
 1.08A 3n8xB-3ndyE:
undetectable		 3n8xB-3ndyE:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nix FLAVOPROTEIN/DEHYDRO
GENASE

(Cytophaga
hutchinsonii) 		PF01494
(FAD_binding_3) 		5 ARG A 105
LEU A  56
GLY A 307
ALA A 308
LEU A  48
 FAD  A 501 (-2.6A)
None
FAD  A 501 (-3.0A)
FAD  A 501 (-3.0A)
None
 1.07A 3n8xB-3nixA:
undetectable		 3n8xB-3nixA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3olq UNIVERSAL STRESS
PROTEIN E

(Proteus
mirabilis) 		PF00582
(Usp) 		5 LEU A 172
GLY A 276
ALA A 279
SER A 278
LEU A 282
 None
 1.09A 3n8xB-3olqA:
undetectable		 3n8xB-3olqA:
21.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3otn SUSD SUPERFAMILY
PROTEIN

(Parabacteroides
distasonis) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 ARG A 325
LEU A 255
LEU A 262
ILE A 413
GLY A 415
 None
 1.12A 3n8xB-3otnA:
0.1		 3n8xB-3otnA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p8l GERANYLTRANSTRANSFER
ASE

(Enterococcus
faecalis) 		PF00348
(polyprenyl_synt) 		5 LEU A 135
LEU A 123
ILE A 186
GLY A 189
ALA A 187
 None
 1.11A 3n8xB-3p8lA:
undetectable		 3n8xB-3p8lA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3plr UDP-GLUCOSE
6-DEHYDROGENASE

(Klebsiella
pneumoniae) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		6 HIS A  23
LEU A 174
PHE A 170
ILE A  19
SER A  14
LEU A 149
 None
 1.30A 3n8xB-3plrA:
undetectable		 3n8xB-3plrA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pov ORF 37

(Human
gammaherpesvirus
8) 		PF01771
(Herpes_alk_exo) 		5 LEU A 453
LEU A 478
ILE A 143
GLY A 217
SER A 210
 None
 0.80A 3n8xB-3povA:
undetectable		 3n8xB-3povA:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q1y LIN2199 PROTEIN

(Listeria
innocua) 		PF00294
(PfkB) 		5 LEU A  41
ILE A  59
GLY A  61
ALA A  60
LEU A  68
 None
 1.12A 3n8xB-3q1yA:
undetectable		 3n8xB-3q1yA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3su8 PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		5 LEU X1640
LEU X1610
PHE X1577
GLY X2083
ALA X2084
 None
 1.08A 3n8xB-3su8X:
undetectable		 3n8xB-3su8X:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 DENN
DOMAIN-CONTAINING
PROTEIN 1B

(Homo sapiens) 		PF02141
(DENN)
PF03455
(dDENN)
PF03456
(uDENN) 		5 LEU A 186
ILE A 210
GLY A 212
ALA A 214
LEU A 217
 None
 1.11A 3n8xB-3tw8A:
undetectable		 3n8xB-3tw8A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twk FORMAMIDOPYRIMIDINE-
DNA GLYCOSYLASE 1

(Arabidopsis
thaliana) 		PF01149
(Fapy_DNA_glyco)
PF06831
(H2TH) 		5 LEU A 193
ILE A 169
ALA A 204
SER A 206
LEU A 207
 None
 1.05A 3n8xB-3twkA:
undetectable		 3n8xB-3twkA:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		5 LEU A 748
LEU A 730
GLY A 778
ALA A 773
SER A 774
 None
 1.05A 3n8xB-3ugmA:
undetectable		 3n8xB-3ugmA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vr0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Pyrococcus
furiosus) 		PF09754
(PAC2) 		5 LEU A 124
LEU A  62
GLY A 191
ALA A 189
LEU A  36
 None
None
None
AU  A 303 (-4.1A)
None
 1.02A 3n8xB-3vr0A:
undetectable		 3n8xB-3vr0A:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wp5 CDBFV

(Neocallimastix
patriciarum) 		PF00457
(Glyco_hydro_11) 		5 LEU A  59
GLY A 204
ALA A 203
SER A  95
LEU A 117
 None
 1.02A 3n8xB-3wp5A:
undetectable		 3n8xB-3wp5A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wpe TOLL-LIKE RECEPTOR 9

(Bos taurus) 		PF13516
(LRR_6)
PF13855
(LRR_8) 		5 LEU A 397
PHE A 375
ILE A 402
ALA A 405
LEU A 407
 None
 0.94A 3n8xB-3wpeA:
undetectable		 3n8xB-3wpeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wsy SORTILIN-RELATED
RECEPTOR

(Homo sapiens) 		PF15901
(Sortilin_C)
PF15902
(Sortilin-Vps10) 		5 HIS A 415
LEU A 453
GLY A 502
ALA A 526
SER A 525
 None
 1.11A 3n8xB-3wsyA:
undetectable		 3n8xB-3wsyA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asy GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Pseudomonas
aeruginosa) 		PF00483
(NTP_transferase) 		5 LEU A  27
LEU A  67
GLY A  10
ALA A   9
SER A  55
 None
 1.05A 3n8xB-4asyA:
undetectable		 3n8xB-4asyA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dn7 ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
mazei) 		PF01458
(UPF0051) 		5 ILE A 296
GLY A 298
ALA A 266
SER A 270
LEU A 272
 None
 1.12A 3n8xB-4dn7A:
undetectable		 3n8xB-4dn7A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		5 LEU A 189
ILE A  90
GLY A  92
ALA A  93
LEU A  97
 None
 0.67A 3n8xB-4eelA:
undetectable		 3n8xB-4eelA:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4emd 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Mycobacteroides
abscessus) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C) 		5 HIS A  37
ILE A 196
ALA A 237
SER A 240
LEU A 241
 C5P  A 401 (-3.7A)
None
None
None
None
 0.85A 3n8xB-4emdA:
undetectable		 3n8xB-4emdA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f8a POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Mus musculus) 		PF00027
(cNMP_binding) 		5 LEU A 607
ILE A 629
ALA A 659
SER A 657
LEU A 701
 None
 1.11A 3n8xB-4f8aA:
undetectable		 3n8xB-4f8aA:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3a CLIP-ASSOCIATING
PROTEIN

(Drosophila
melanogaster) 		PF12348
(CLASP_N) 		5 LEU A  76
LEU A 113
ILE A  51
GLY A  53
LEU A  58
 None
 1.08A 3n8xB-4g3aA:
undetectable		 3n8xB-4g3aA:
16.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h27 L-SERINE
DEHYDRATASE/L-THREON
INE DEAMINASE

(Homo sapiens) 		PF00291
(PALP) 		5 ILE A 282
GLY A  24
ALA A  23
SER A  20
LEU A  19
 None
 1.12A 3n8xB-4h27A:
undetectable		 3n8xB-4h27A:
20.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ii2 UBIQUITIN-CONJUGATIN
G ENZYME E2 4

(Schizosaccharomyces
pombe) 		PF00179
(UQ_con) 		5 LEU C 104
PHE C  56
ILE C  54
GLY C  24
ALA C  23
 None
 1.09A 3n8xB-4ii2C:
undetectable		 3n8xB-4ii2C:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ky9 BAND 3 ANION
TRANSPORT PROTEIN

(Homo sapiens) 		PF07565
(Band_3_cyto) 		5 HIS A 161
LEU A 269
GLY A 130
ALA A 132
LEU A 136
 None
 1.00A 3n8xB-4ky9A:
undetectable		 3n8xB-4ky9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1o RIBONUCLEASE L

(Sus scrofa) 		PF00069
(Pkinase)
PF06479
(Ribonuc_2-5A)
PF12796
(Ank_2)
PF13857
(Ank_5) 		5 HIS A 474
LEU A 466
LEU A 578
GLY A 522
LEU A 559
 None
 1.10A 3n8xB-4o1oA:
undetectable		 3n8xB-4o1oA:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p7h MYOSIN-7,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria;
Homo sapiens) 		PF00063
(Myosin_head)
PF01353
(GFP)
PF02736
(Myosin_N) 		5 LEU A 614
TYR A 609
LEU A 390
GLY A 354
ALA A 355
 None
 0.98A 3n8xB-4p7hA:
undetectable		 3n8xB-4p7hA:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfw ABC TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Thermotoga
maritima) 		PF00496
(SBP_bac_5) 		5 PHE A 245
ILE A 552
GLY A 548
ALA A 536
LEU A  67
 None
 1.10A 3n8xB-4pfwA:
undetectable		 3n8xB-4pfwA:
22.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 HIS A  90
ARG A 121
LEU A 353
TYR A 356
LEU A 360
TRP A 388
GLY A 527
ALA A 528
SER A 531
LEU A 532
 None
BOG  A 604 ( 3.7A)
IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
IBP  A 601 (-3.9A)
IBP  A 601 (-3.4A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.61A 3n8xB-4ph9A:
57.9		 3n8xB-4ph9A:
64.31
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ph9 PROSTAGLANDIN G/H
SYNTHASE 2

(Mus musculus) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 LEU A 353
TYR A 356
LEU A 360
TRP A 388
PHE A 519
GLY A 527
SER A 531
LEU A 532
 IBP  A 601 ( 4.7A)
IBP  A 601 (-4.5A)
IBP  A 601 ( 4.7A)
None
None
IBP  A 601 (-3.9A)
IBP  A 601 ( 3.3A)
IBP  A 601 ( 4.9A)
 0.73A 3n8xB-4ph9A:
57.9		 3n8xB-4ph9A:
64.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q8l ALGINASE

(Pseudoalteromonas
sp. SM0524) 		PF08787
(Alginate_lyase2) 		5 HIS A  91
LEU A 151
GLY A 170
SER A 168
LEU A 140
 None
 1.12A 3n8xB-4q8lA:
undetectable		 3n8xB-4q8lA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ri2 PHOTOSYSTEM II 22
KDA PROTEIN,
CHLOROPLASTIC

(Spinacia
oleracea) 		PF00504
(Chloroa_b-bind) 		5 LEU A 156
PHE A  84
GLY A  47
SER A  51
LEU A  52
 None
BNG  A 301 (-4.9A)
None
None
None
 1.08A 3n8xB-4ri2A:
undetectable		 3n8xB-4ri2A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rs1 GRANULOCYTE-MACROPHA
GE
COLONY-STIMULATING
FACTOR

(Homo sapiens) 		PF01109
(GM_CSF) 		5 HIS A  15
LEU A  77
TYR A  84
LEU A  55
ILE A  19
 None
 1.09A 3n8xB-4rs1A:
undetectable		 3n8xB-4rs1A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A

(Pseudomonas
aeruginosa) 		PF01425
(Amidase) 		5 LEU A 165
GLY A 155
ALA A 158
SER A  41
LEU A  39
 None
 1.04A 3n8xB-4wj3A:
undetectable		 3n8xB-4wj3A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wt5 RUBISCO ACCUMULATION
FACTOR 1, ISOFORM 2

(Arabidopsis
thaliana) 		no annotation 5 LEU A 400
LEU A 415
PHE A 365
GLY A 406
ALA A 403
 None
 1.07A 3n8xB-4wt5A:
undetectable		 3n8xB-4wt5A:
14.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A 177
LEU A 142
GLY A 154
ALA A 155
LEU A 132
 None
 1.12A 3n8xB-4yeiA:
undetectable		 3n8xB-4yeiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yei BETA1MUT

(synthetic
construct) 		PF00805
(Pentapeptide) 		5 LEU A 182
LEU A 147
GLY A 159
ALA A 160
LEU A 137
 None
 1.05A 3n8xB-4yeiA:
undetectable		 3n8xB-4yeiA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj1 UNCHARACTERIZED
PROTEIN

(Trypanosoma
brucei) 		PF09818
(ABC_ATPase) 		5 LEU A  72
ILE A 207
GLY A 205
ALA A 206
LEU A 194
 None
 0.95A 3n8xB-4yj1A:
1.4		 3n8xB-4yj1A:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bul FLAVIN-DEPENDENT
HALOGENASE TRIPLE
MUTANT

(Streptomyces) 		PF04820
(Trp_halogenase) 		5 LEU A 153
ILE A  11
GLY A  13
ALA A 156
SER A 157
 None
None
FAD  A 501 (-3.2A)
None
FAD  A 501 (-4.7A)
 1.09A 3n8xB-5bulA:
1.2		 3n8xB-5bulA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cw2 PUTATIVE EPOXIDE
HYDROLASE EPHA

(Mycolicibacterium
thermoresistibile) 		no annotation 5 TYR C  76
LEU C  81
PHE C 226
GLY C  65
LEU C  16
 None
 1.00A 3n8xB-5cw2C:
undetectable		 3n8xB-5cw2C:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ex2 PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE

(Hirschia
baltica) 		PF00160
(Pro_isomerase) 		5 TYR A  58
LEU A 211
ILE A  49
GLY A 187
LEU A 171
 None
 1.00A 3n8xB-5ex2A:
undetectable		 3n8xB-5ex2A:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exx TRANSCRIPTIONAL
REGULATOR FLEQ

(Pseudomonas
aeruginosa) 		PF00158
(Sigma54_activat) 		5 HIS A 376
LEU A 368
ALA A 349
SER A 352
LEU A 353
 None
 1.02A 3n8xB-5exxA:
undetectable		 3n8xB-5exxA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gmh TOLL-LIKE RECEPTOR 7

(Macaca mulatta) 		PF00560
(LRR_1)
PF13306
(LRR_5)
PF13855
(LRR_8) 		5 LEU A 404
PHE A 382
ILE A 409
ALA A 412
LEU A 414
 None
 1.02A 3n8xB-5gmhA:
undetectable		 3n8xB-5gmhA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h42 UNCHARACTERIZED
PROTEIN

(Lachnoclostridium
phytofermentans) 		PF17167
(Glyco_hydro_36) 		5 ARG A 743
LEU A 773
LEU A 745
GLY A 755
ALA A 754
 None
 0.86A 3n8xB-5h42A:
undetectable		 3n8xB-5h42A:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hws 2-DEHYDROPANTOATE
2-REDUCTASE

(Thermococcus
kodakarensis) 		PF02558
(ApbA)
PF08546
(ApbA_C) 		5 LEU A  18
LEU A  43
ILE A  11
GLY A 123
ALA A 124
 None
None
NAP  A 401 (-3.9A)
NAP  A 401 (-3.7A)
NAP  A 401 (-3.7A)
 1.07A 3n8xB-5hwsA:
undetectable		 3n8xB-5hwsA:
19.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		10 HIS A  90
ARG A 120
LEU A 352
TYR A 355
LEU A 359
TRP A 387
GLY A 526
ALA A 527
SER A 530
LEU A 531
 None
ID8  A 601 ( 4.4A)
ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.62A 3n8xB-5ikrA:
58.3		 3n8xB-5ikrA:
63.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ikr PROSTAGLANDIN G/H
SYNTHASE 2

(Homo sapiens) 		PF00008
(EGF)
PF03098
(An_peroxidase) 		8 LEU A 352
TYR A 355
LEU A 359
TRP A 387
PHE A 518
GLY A 526
SER A 530
LEU A 531
 ID8  A 601 (-4.1A)
ID8  A 601 (-3.8A)
None
COH  A 602 (-4.5A)
None
ID8  A 601 (-3.5A)
ID8  A 601 (-2.7A)
ID8  A 601 (-3.5A)
 0.80A 3n8xB-5ikrA:
58.3		 3n8xB-5ikrA:
63.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jcd CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		5 LEU A 199
PHE A 132
ILE A 216
GLY A 214
LEU A 211
 None
 1.08A 3n8xB-5jcdA:
undetectable		 3n8xB-5jcdA:
17.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jce CHITIN
ELICITOR-BINDING
PROTEIN

(Oryza sativa) 		PF01476
(LysM) 		5 LEU A 199
PHE A 132
ILE A 216
GLY A 214
LEU A 211
 None
 1.00A 3n8xB-5jceA:
undetectable		 3n8xB-5jceA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkj ESTERASE E22

(uncultured
bacterium) 		PF00561
(Abhydrolase_1) 		5 LEU A 304
LEU A 117
GLY A 239
SER A 243
LEU A 244
 None
 1.04A 3n8xB-5jkjA:
undetectable		 3n8xB-5jkjA:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo5 10E8 GLV

(Homo sapiens) 		no annotation 5 PHE L  62
ILE L  75
GLY L  77
ALA L  78
LEU L  15
 None
 1.08A 3n8xB-5jo5L:
undetectable		 3n8xB-5jo5L:
17.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k7l POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY H
MEMBER 1

(Rattus
norvegicus) 		PF00027
(cNMP_binding)
PF00520
(Ion_trans)
PF13426
(PAS_9) 		5 LEU A 580
ILE A 602
ALA A 632
SER A 630
LEU A 674
 None
 0.85A 3n8xB-5k7lA:
undetectable		 3n8xB-5k7lA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koi ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Brucella
abortus) 		PF13561
(adh_short_C2) 		5 LEU A  89
PHE A  76
ILE A  79
ALA A  37
LEU A  36
 None
 0.97A 3n8xB-5koiA:
undetectable		 3n8xB-5koiA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6q H5AL

(Homo sapiens) 		PF07686
(V-set) 		5 PHE A  60
ILE A  73
GLY A  75
ALA A  76
LEU A  13
 None
 1.11A 3n8xB-5l6qA:
undetectable		 3n8xB-5l6qA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m32 PROTEASOME SUBUNIT
BETA TYPE-2

(Homo sapiens) 		PF00227
(Proteasome) 		5 LEU J   4
TYR J 117
GLY J 135
ALA J 136
LEU J 140
 None
 1.02A 3n8xB-5m32J:
undetectable		 3n8xB-5m32J:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ndx GLYCOSYL HYDROLASE

(Rhizobium
leguminosarum) 		no annotation 5 HIS A 314
LEU A 372
ILE A 288
GLY A 286
ALA A 285
 None
 1.09A 3n8xB-5ndxA:
undetectable		 3n8xB-5ndxA:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc1 ARYL-ALCOHOL OXIDASE

(Pleurotus
eryngii) 		no annotation 5 LEU A 366
LEU A 192
PHE A 373
ALA A 380
SER A 418
 None
 1.09A 3n8xB-5oc1A:
undetectable		 3n8xB-5oc1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tf4 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Bartonella
henselae) 		PF13561
(adh_short_C2) 		5 LEU A  92
PHE A  79
ILE A  82
ALA A  40
LEU A  39
 None
 1.11A 3n8xB-5tf4A:
undetectable		 3n8xB-5tf4A:
17.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ufy ACYLTRANSFERASE

(Streptococcus
pneumoniae) 		no annotation 5 LEU A 441
TRP A 564
ILE A 579
GLY A 582
ALA A 583
 None
 0.93A 3n8xB-5ufyA:
undetectable		 3n8xB-5ufyA:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viq MONOMERIC
NEAR-INFRARED
FLUORESCENT PROTEIN
MIRFP709

(Rhodopseudomonas
palustris) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 LEU A  75
PHE A 246
GLY A  35
ALA A  36
LEU A  58
 None
 0.97A 3n8xB-5viqA:
undetectable		 3n8xB-5viqA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3j TOLL-LIKE RECEPTOR 9

(Equus caballus) 		no annotation 5 LEU A 398
LEU A 477
PHE A 376
ILE A 403
ALA A 406
 None
 1.12A 3n8xB-5y3jA:
undetectable		 3n8xB-5y3jA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byq TYROSINE--TRNA
LIGASE

(Helicobacter
pylori) 		no annotation 5 LEU A  76
LEU A  63
TRP A 130
GLY A 186
ALA A 187
 None
 1.09A 3n8xB-6byqA:
undetectable		 3n8xB-6byqA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 LEU A 325
ILE A 155
GLY A 157
ALA A 156
LEU A 309
 None
 1.02A 3n8xB-6dllA:
0.1		 3n8xB-6dllA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ged PRGB

(Enterococcus
faecalis) 		no annotation 6 LEU A 273
LEU A 551
PHE A 420
ILE A 523
ALA A 519
LEU A 518
 None
 1.42A 3n8xB-6gedA:
undetectable		 3n8xB-6gedA:
9.30